Structure information

TA1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8WC7

SPECIES

Mus musculus

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2023.10.014

PUBLICATION DATE

Dec. 27, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine D102 3.32x32 TM3 polar (charge-assisted hydrogen bond)
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine I103 3.33x33 TM3 hydrophobic
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine I103 3.33x33 TM3 Van der Waals
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine S107 3.37x37 TM3 Van der Waals
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine S107 3.37x37 TM3 polar (hydrogen bond)
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine Y153 4.56x56 TM4 Van der Waals
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine Y153 4.56x56 TM4 polar (hydrogen bond)
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine A193 5.42x43 TM5 hydrophobic
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine A193 5.42x43 TM5 Van der Waals
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine S197 5.46x461 TM5 polar (hydrogen bond)
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine S197 5.46x461 TM5 Van der Waals
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine W261 6.48x48 TM6 hydrophobic
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine F264 6.51x51 TM6 hydrophobic
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine F264 6.51x51 TM6 Van der Waals
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine F265 6.52x52 TM6 hydrophobic
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine F265 6.52x52 TM6 Van der Waals
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine Y287 7.39x38 TM7 hydrophobic
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine Y287 7.39x38 TM7 Van der Waals
2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine Y291 7.43x42 TM7 polar (hydrogen bond)

Ligands

2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine

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Residue Diagrams

L N G V L T A L I I L S M L S Y L S A Q 1 H S M A I V D F L L G L C I M P C S M V R 2 F A L H F I S A S S L M I D T S T H V K 3 I L V M I L V S W S L P A V Y A F G M I 4 Y V F L M V S G P I Y F S T M F A L V G S 5 G I M V G V F L V C W C P F F L C T V L 6 M P N L A S N L Y G F W Y L A D N L S 7
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ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L R Y K A K I ICL2ECL2 L N L K G V E E L Y R S Q V S D L G G C S P F F ECL2ICL3 L E G K S Q ICL3ECL3 Y V I ECL3N-term M H L C H A I T N I S H R N S D W S R E N-termC-term G K I F Q K D S S R S K L F L C-term V Q A S L Y S L M S L I I L A T L V G N L I V I I S I S H F T P T N W L L H S M A I V D F L L G C L I M P C S M V R T V E R G E I L C K V H T S T D I M L S S A S I F H L A F I S I D R Y C A V C D N I S T I L V M I L V S W S L P A V Y A F G M I F L E S K V S G V L A F M T S F Y I P G S V M L F V Y Y R I Y F I A K G Q A R S I N R T N V Q V G A P Q S K E T K A A K T L G I M V G V F L V C W C P F F L C T V L D P F L G P P S L N D A L Y W F G Y L N S A L N P M V Y A F F Y P W L K M F R R A V L L
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Residue Table


GPCRdb(A)
GPCRdb(A)
TA1 receptor
TM3
3x32 3.32x32 D102
3x33 3.33x33 I103
3x37 3.37x37 S107
TM4
4x56 4.56x56 Y153
TM5
5x43 5.42x43 A193
5x461 5.46x461 S197
TM6
6x48 6.48x48 W261
6x51 6.51x51 F264
6x52 6.52x52 F265
TM7
7x38 7.39x38 Y287
7x42 7.43x42 Y291