GPCRdb

endomorphin-2

Agent/drug
Bioactivity

endomorphin-2

SMILES	None
InChIKey	XIJHWXXXIMEHKW-LJWNLINESA-N
Sequence	YPFF

Chemical Properties

Hydrogen bond acceptors	None
Hydrogen bond donors	None
Rotatable bonds	None
Molecular weight (Da)

Database connections

Guide To Pharmacology ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

δ	OPRD	Rat	Opioid	A	pKi	5.02	5.19	5.64	ChEMBL
δ	OPRD	Human	Opioid	A	pKi	5.10	5.25	5.47	ChEMBL
δ	F1N083	Bovine	Opioid	A	pKi	6.30	6.30	6.30	PDSP Ki database
κ	OPRK	Rat	Opioid	A	pKi	7.97	7.97	7.97	ChEMBL
κ	OPRK	Guinea pig	Opioid	A	pKi	5.11	5.34	5.57	ChEMBL
κ	OPRK	Guinea pig	Opioid	A	pKi	6.30	6.30	6.30	PDSP Ki database
κ	OPRK	Human	Opioid	A	pKi	5.28	5.62	5.95	ChEMBL
μ	OPRM	Rat	Opioid	A	pKi	8.50	8.50	8.50	Guide to Pharmacology
μ	OPRM	Rat	Opioid	A	pKi	7.72	8.53	9.31	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	8.09	8.57	9.16	ChEMBL
μ	OPRM	Rat	Opioid	A	pKi	7.71	8.51	9.24	PDSP Ki database
μ	OPRM	Mouse	Opioid	A	pKi	8.80	8.83	8.86	PDSP Ki database
μ	OPRM	Bovine	Opioid	A	pKi	9.37	9.37	9.37	PDSP Ki database
NK₁	NK1R	Rat	Tachykinin	A	pKi	7.52	7.88	8.06	ChEMBL

Showing 1 to 14 of 14 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

δ	OPRD	Mouse	Opioid	A	pIC50	6.29	6.93	7.82	ChEMBL
δ	OPRD	Rat	Opioid	A	pIC50	4.99	4.99	4.99	ChEMBL
μ	OPRM	Mouse	Opioid	A	pIC50	7.62	7.70	7.78	ChEMBL
μ	OPRM	Rat	Opioid	A	pIC50	8.46	9.00	9.16	ChEMBL
μ	OPRM	Rat	Opioid	A	pEC50	6.42	6.73	7.11	ChEMBL
μ	OPRM	Human	Opioid	A	pEC50	7.20	8.25	10.40	ChEMBL

Showing 1 to 6 of 6 entries

endomorphin-2

Drug properties

Molecular type	Peptide
Physiological/Surrogate	Endogenous
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV 0

Database connections

Guide To Pharmacology ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.