orforglipron



orforglipron

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SMILES C[C@H]1C[C@]1(c1noc(=O)[nH]1)n1c2c(cc(cc2)[C@H]2CCOC(C2)(C)C)cc1C(=O)N1CCc2nn(c(c2[C@@H]1C)n1ccn(c1=O)c1c(c2c(cc1)n(nc2)C)F)c1cc(c(c(c1)C)F)C
InChIKey USUWIEBBBWHKNI-KHIFEHGGSA-N

Chemical Properties

Hydrogen bond acceptors 13
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 882.4

Database connections

Structure pdb 6XOX 7E14

Bioactivities

Receptor Activity Source
Protein Gene Species Family Class Type Min Avg Max Database
Receptor Activity Source
Protein Gene Species Family Class Type Min Avg Max Database

orforglipron

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Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Clinical Trials

Phase I 0
Phase II 0
Phase III 2
Approved No

Database connections

Structure pdb 6XOX 7E14

Sankey plot

Drug Information

Target Disease Phase
Gene Protein Receptor family Ligand type Class Indication name ICD11 ATC Association score Phase Approved