GPCRdb

AM251

Agent/drug
Bioactivity

AM251

SMILES	Cc1c(C(=O)NN2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(I)cc1
InChIKey	BUZAJRPLUGXRAB-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	4
Molecular weight (Da)	554.0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	8ZX5

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

CB₁	CNR1	Rat	Cannabinoid	A	pKi	8.10	8.10	8.10	Guide to Pharmacology
CB₁	CNR1	Human	Cannabinoid	A	pKi	8.12	8.43	8.64	ChEMBL
CB₁	CNR1	Human	Cannabinoid	A	pKi	8.64	8.64	8.64	PDSP Ki database
CB₂	CNR2	Human	Cannabinoid	A	pKi	6.95	6.95	6.96	PDSP Ki database
CB₂	CNR2	Human	Cannabinoid	A	pKi	5.64	6.73	6.96	ChEMBL
CB₂	CNR2	Mouse	Cannabinoid	A	pKi	5.64	5.64	5.64	ChEMBL

Showing 1 to 6 of 6 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

CB₁	CNR1	Human	Cannabinoid	A	pIC50	6.47	7.87	9.49	ChEMBL
CB₁	CNR1	Human	Cannabinoid	A	pEC50	7.16	7.19	7.24	ChEMBL
GPR18	GPR18	Human	GPR18, GPR55 and GPR119	A	pEC50	4.02	4.02	4.02	Guide to Pharmacology
GPR55	GPR55	Human	GPR18, GPR55 and GPR119	A	pEC50	5.02	6.21	7.41	Guide to Pharmacology
GPR55	GPR55	Human	GPR18, GPR55 and GPR119	A	pEC50	6.20	6.20	6.20	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	5.00	5.00	5.00	ChEMBL

Showing 1 to 6 of 6 entries

AM251

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	8ZX5

Compound is not listed as a drug.