GPCRdb

tryptamine

Agent/drug
Bioactivity

tryptamine

SMILES	NCCc1c[nH]c2ccccc12
InChIKey	APJYDQYYACXCRM-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	1
Hydrogen bond donors	2
Rotatable bonds	2
Molecular weight (Da)	160.1

Database connections

Guide To Pharmacology DrugBank ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	5-HT_2A 5-HT_2C

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.77	6.77	6.77	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.98	6.98	6.98	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.21	5.43	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.30	6.30	6.30	Guide to Pharmacology
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	4.99	4.99	4.99	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	7.44	7.44	7.44	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.50	5.99	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.28	6.68	7.07	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.80	7.10	7.40	Guide to Pharmacology
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	7.21	7.42	7.64	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.28	7.02	7.38	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	6.53	7.15	7.44	PDSP Ki database
5-HT_1D	5HT1D	Dog	5-Hydroxytryptamine	A	pKi	6.46	6.46	6.46	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.60	6.05	6.50	Guide to Pharmacology
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.59	5.59	5.59	PDSP Ki database
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	5.60	5.60	5.60	Guide to Pharmacology
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	5.62	5.62	5.62	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.50	6.55	7.60	Guide to Pharmacology
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	6.10	7.05	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.00	7.00	7.00	Guide to Pharmacology

Showing 1 to 20 of 43 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pEC50	8.13	8.13	8.13	ChEMBL
TA₁	TAAR1	Rat	Trace amine	A	pEC50	6.51	6.51	6.51	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pEC50	5.66	5.66	5.66	ChEMBL

Showing 1 to 3 of 3 entries

tryptamine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Endogenous
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

Guide To Pharmacology DrugBank ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	5-HT_2A 5-HT_2C

Compound is not listed as a drug.