GPCRdb

UNC9975

Agent/drug
Bioactivity

UNC9975

SMILES	O=C1CCc2ccc(OCCCCN3CCCN(c4cccc(Cl)c4Cl)CC3)nc2N1
InChIKey	JQSRFMXTGAVHIR-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	7
Molecular weight (Da)	462.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.54	7.54	7.54	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.13	8.13	8.13	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.96	8.96	8.96	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	7.00	7.00	7.00	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	5.98	5.98	5.98	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	8.59	8.59	8.59	Guide to Pharmacology
D₂	DRD2	Human	Dopamine	A	pKi	8.59	8.81	8.92	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	7.96	7.96	7.96	ChEMBL
D₄	DRD4	Human	Dopamine	A	pKi	6.75	6.75	6.75	ChEMBL
D₅	DRD5	Human	Dopamine	A	pKi	6.29	6.29	6.29	ChEMBL

Showing 1 to 10 of 10 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	5.75	5.75	5.75	ChEMBL
D₂	DRD2	Human	Dopamine	A	pEC50	8.96	8.96	8.96	Guide to Pharmacology
D₂	DRD2	Human	Dopamine	A	pEC50	7.89	8.39	8.80	ChEMBL

Showing 1 to 3 of 3 entries

UNC9975

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.