GPCRdb

vasopressin

Agent/drug
Bioactivity

vasopressin

SMILES	None
InChIKey	KBZOIRJILGZLEJ-LGYYRGKSSA-N
Sequence	CYFQNCPRG

Chemical Properties

Hydrogen bond acceptors	None
Hydrogen bond donors	None
Rotatable bonds	None
Molecular weight (Da)

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	7R0C 7KH0 7BB7 7DW9 7BB6

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

OT	OXYR	Human	Vasopressin and oxytocin	A	pKi	7.30	8.30	9.30	Guide to Pharmacology
OT	OXYR	Rat	Vasopressin and oxytocin	A	pKi	8.93	8.93	8.93	ChEMBL
OT	OXYR	Human	Vasopressin and oxytocin	A	pKi	7.92	8.48	8.78	ChEMBL
V_1A	V1AR	Human	Vasopressin and oxytocin	A	pKi	8.50	8.90	9.30	Guide to Pharmacology
V_1A	V1AR	Rat	Vasopressin and oxytocin	A	pKd	9.19	9.19	9.19	ChEMBL
V_1A	V1AR	Rat	Vasopressin and oxytocin	A	pKi	8.81	8.81	8.81	ChEMBL
V_1A	V1AR	Human	Vasopressin and oxytocin	A	pKi	8.40	9.00	9.59	ChEMBL
V_1A	V1AR	Rat	Vasopressin and oxytocin	A	pKi	8.40	8.40	8.40	Guide to Pharmacology
V_1B	V1BR	Human	Vasopressin and oxytocin	A	pKi	9.00	9.25	9.50	Guide to Pharmacology
V_1B	V1BR	Rat	Vasopressin and oxytocin	A	pKi	9.90	9.90	9.90	Guide to Pharmacology
V_1B	V1BR	Rat	Vasopressin and oxytocin	A	pKi	9.54	9.54	9.54	ChEMBL
V_1B	V1BR	Human	Vasopressin and oxytocin	A	pKi	8.70	9.06	9.31	ChEMBL
V₂	V2R	Human	Vasopressin and oxytocin	A	pKi	7.90	8.50	9.10	Guide to Pharmacology
V₂	V2R	Bovine	Vasopressin and oxytocin	A	pKd	8.82	8.82	8.82	ChEMBL
V₂	V2R	Rat	Vasopressin and oxytocin	A	pKi	9.35	9.35	9.35	ChEMBL
V₂	V2R	Rat	Vasopressin and oxytocin	A	pKd	8.82	8.82	8.82	ChEMBL
V₂	V2R	Human	Vasopressin and oxytocin	A	pKi	7.50	8.53	8.92	ChEMBL

Showing 1 to 17 of 17 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

OT	OXYR	Human	Vasopressin and oxytocin	A	pEC50	7.39	8.13	10.00	ChEMBL
V_1A	V1AR	Rat	Vasopressin and oxytocin	A	pEC50	10.15	10.18	10.20	ChEMBL
V_1A	V1AR	Human	Vasopressin and oxytocin	A	pEC50	7.50	9.11	9.63	ChEMBL
V_1B	V1BR	Human	Vasopressin and oxytocin	A	pEC50	7.96	8.37	8.70	ChEMBL
V₂	V2R	Pig	Vasopressin and oxytocin	A	pIC50	8.48	8.48	8.48	ChEMBL
V₂	V2R	Human	Vasopressin and oxytocin	A	pEC50	10.28	10.29	10.30	ChEMBL
V₂	V2R	Human	Vasopressin and oxytocin	A	pIC50	6.62	6.62	6.62	ChEMBL

Showing 1 to 7 of 7 entries

vasopressin

Drug properties

Molecular type	Peptide
Physiological/Surrogate	Endogenous
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 22

Phase III 16

Phase IV 12

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	7R0C 7KH0 7BB7 7DW9 7BB6

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Autism spectrum disorder, unspecified	2	6A02.Z		0.310
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Central diabetes insipidus	4	5A61.5		0.037
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Diseases of the circulatory system, unspecified	2	BE2Z		0.001
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Haemorrhage, not elsewhere classified	3	MG27		0.572
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Injury of lung, unspecified	2	NB32.3Z		0.013
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Pulmonary hypertension, unspecified	2	BB01.Z		0.009
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Shock, unspecified	4	MG40.Z		0.001
OXYR	OT receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Single episode depressive disorder, severe, without psychotic symptoms	2	6A70.3		0.056
V1AR	V_1A receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Autism spectrum disorder, unspecified	2	6A02.Z		0.129
V1AR	V_1A receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Cardiac arrest, unspecified	3	MC82.Z		0.287
V1AR	V_1A receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Central diabetes insipidus	4	5A61.5		0.566
V1AR	V_1A receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Diseases of the circulatory system, unspecified	2	BE2Z		0.370
V1AR	V_1A receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Diseases of the myocardium or cardiac chambers, unspecified	3	BC4Z		0.259
V1AR	V_1A receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Haemorrhage, not elsewhere classified	3	MG27		0.591
V1AR	V_1A receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Hypotension, unspecified	4	BA2Z		0.020
V1AR	V_1A receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Injury of lung, unspecified	2	NB32.3Z		0.074
V1AR	V_1A receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Pulmonary hypertension, unspecified	2	BB01.Z		0.074
V1AR	V_1A receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Sepsis with septic shock	3	1G41		0.559
V1AR	V_1A receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Shock, unspecified	4	MG40.Z		0.448
V1AR	V_1A receptor	Vasopressin and oxytocin receptors	Peptide receptors	A	Single episode depressive disorder, severe, without psychotic symptoms	2	6A70.3		0.074

Showing 1 to 20 of 43 entries

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vasopressin

vasopressin

Chemical Properties

Database connections

Bioactivities

vasopressin

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information