CDPPB
| SMILES | N#Cc1cccc(c1)C(=O)Nc1cc(nn1c1ccccc1)c1ccccc1 |
| InChIKey | BKUIZWILNWHFHD-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 4 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 4 |
| Molecular weight (Da) | 364.1 |
Drug properties
| Molecular type | Small molecule |
| Endogenous/Surrogate | Surrogate |
| Approved drug | No |
Database connections
| Ligand site mutations | mGlu5 |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| mGlu5 | GRM5 | Rat | Metabotropic glutamate | C | pKi | 5.42 | 5.42 | 5.42 | ChEMBL |
| mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pKi | 6.6 | 6.6 | 6.6 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pEC50 | 7.6 | 7.8 | 8.0 | Guide to Pharmacology |
| mGlu5 | GRM5 | Rat | Metabotropic glutamate | C | pEC50 | 7.7 | 7.7 | 7.7 | Guide to Pharmacology |
| mGlu5 | GRM5 | Rat | Metabotropic glutamate | C | pEC50 | 7.01 | 7.27 | 7.7 | ChEMBL |
| mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pEC50 | 6.75 | 7.27 | 8.0 | ChEMBL |