Ligand source activities (1 row/activity)





Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Potency)
# tested GPCRs
(Potency)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
1902746 31853 7 None - 1 Human 4.3 pEC50 = 4.3 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify agonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 864 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify agonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 864 ]
ChEMBL 360 6 1 5 3.8 C=CCNC(=O)/C(C#N)=C/c1cn(-c2ccccc2)nc1-c1cccs1 nan
CHEMBL1408432 31853 7 None - 1 Human 4.3 pEC50 = 4.3 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify agonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 864 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify agonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 864 ]
ChEMBL 360 6 1 5 3.8 C=CCNC(=O)/C(C#N)=C/c1cn(-c2ccccc2)nc1-c1cccs1 nan
4104905 36272 7 None 1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 297 5 1 7 1.6 CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O nan
CHEMBL1447697 36272 7 None 1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 297 5 1 7 1.6 CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O nan
1478923 51698 16 None -1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 265 4 1 4 2.9 O=C(/C=C/Sc1nc[nH]n1)c1ccc(Cl)cc1 nan
CHEMBL1586531 51698 16 None -1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 265 4 1 4 2.9 O=C(/C=C/Sc1nc[nH]n1)c1ccc(Cl)cc1 nan
638439 103322 69 None 2 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
ChEMBL 195 3 1 4 1.6 COc1cc(/C=C/[N+](=O)[O-])ccc1O nan
CHEMBL309016 103322 69 None 2 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
ChEMBL 195 3 1 4 1.6 COc1cc(/C=C/[N+](=O)[O-])ccc1O nan
4686258 51569 7 None - 1 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 278 4 2 8 1.5 CNc1nc2cc([N+](=O)[O-])c([N+](=O)[O-])cc2nc1NC nan
CHEMBL1585420 51569 7 None - 1 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 278 4 2 8 1.5 CNc1nc2cc([N+](=O)[O-])c([N+](=O)[O-])cc2nc1NC nan
3775080 37609 17 None -1 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 306 4 0 6 2.9 CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12 nan
CHEMBL1458812 37609 17 None -1 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 306 4 0 6 2.9 CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12 nan
1478923 51698 16 None -1 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
ChEMBL 265 4 1 4 2.9 O=C(/C=C/Sc1nc[nH]n1)c1ccc(Cl)cc1 nan
CHEMBL1586531 51698 16 None -1 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
ChEMBL 265 4 1 4 2.9 O=C(/C=C/Sc1nc[nH]n1)c1ccc(Cl)cc1 nan
3775080 37609 17 None -1 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
ChEMBL 306 4 0 6 2.9 CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12 nan
CHEMBL1458812 37609 17 None -1 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
ChEMBL 306 4 0 6 2.9 CC(=O)SC(C[N+](=O)[O-])c1cn(C(C)=O)c2ccccc12 nan
2585250 28145 7 None -5 3 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
ChEMBL 396 6 1 5 2.2 CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O nan
CHEMBL1374788 28145 7 None -5 3 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
ChEMBL 396 6 1 5 2.2 CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O nan
5335764 45653 8 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
ChEMBL 342 5 1 3 4.5 Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3cccnc3)cc2)c1 nan
CHEMBL1531933 45653 8 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
ChEMBL 342 5 1 3 4.5 Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3cccnc3)cc2)c1 nan
5335764 45653 8 None - 1 Human 4.7 pIC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 342 5 1 3 4.5 Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3cccnc3)cc2)c1 nan
CHEMBL1531933 45653 8 None - 1 Human 4.7 pIC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 342 5 1 3 4.5 Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3cccnc3)cc2)c1 nan
5064340 40182 1 None - 1 Human 4.3 pIC50 = 4.3 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 337 3 2 5 5.4 Nc1[nH]c(N=Nc2nc(-c3ccc(F)cc3)cs2)c2ccccc12 nan
CHEMBL1482215 40182 1 None - 1 Human 4.3 pIC50 = 4.3 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 337 3 2 5 5.4 Nc1[nH]c(N=Nc2nc(-c3ccc(F)cc3)cs2)c2ccccc12 nan
919665 24376 7 None - 1 Human 4.3 pIC50 = 4.3 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 343 2 1 5 2.5 CCOC(=O)N1CCN(c2[nH]cnc3c4cc(F)ccc4nc2-3)CC1 nan
CHEMBL1342746 24376 7 None - 1 Human 4.3 pIC50 = 4.3 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 343 2 1 5 2.5 CCOC(=O)N1CCN(c2[nH]cnc3c4cc(F)ccc4nc2-3)CC1 nan
2585042 46582 7 None -3 4 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 480 4 0 6 2.2 O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 nan
CHEMBL1540377 46582 7 None -3 4 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 480 4 0 6 2.2 O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 nan
1345012 34763 9 None - 1 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 425 5 3 4 4.7 O=C(/C=C/c1ccc(Cl)cc1)NC(=S)Nc1ccc(NC(=O)c2ccco2)cc1 nan
CHEMBL1432794 34763 9 None - 1 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 425 5 3 4 4.7 O=C(/C=C/c1ccc(Cl)cc1)NC(=S)Nc1ccc(NC(=O)c2ccco2)cc1 nan
4104905 36272 7 None 1 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
ChEMBL 297 5 1 7 1.6 CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O nan
CHEMBL1447697 36272 7 None 1 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
ChEMBL 297 5 1 7 1.6 CCOC(=O)c1cc([N+](=O)[O-])c([N+](=O)[O-])cc1NC(C)=O nan
2585250 28145 7 None -5 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 396 6 1 5 2.2 CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O nan
CHEMBL1374788 28145 7 None -5 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 396 6 1 5 2.2 CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O nan
260557 36779 16 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 326 3 1 4 3.7 CN(C)c1ccc(NC2=C(Cl)C(=O)c3ccccc3C2=O)cc1 nan
CHEMBL1451772 36779 16 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 326 3 1 4 3.7 CN(C)c1ccc(NC2=C(Cl)C(=O)c3ccccc3C2=O)cc1 nan
3319616 30954 3 None 2 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 252 3 0 7 2.0 O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1 nan
CHEMBL1400481 30954 3 None 2 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]PUBCHEM_BIOASSAY: Dose Response cell-based high-throughput screening assay to identify antagonists of galanin receptor 2 (GALR2). (Class of assay: confirmatory) [Related pubchem assays: 828, 866 ]
ChEMBL 252 3 0 7 2.0 O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1 nan
3319616 30954 3 None 2 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
ChEMBL 252 3 0 7 2.0 O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1 nan
CHEMBL1400481 30954 3 None 2 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]PUBCHEM_BIOASSAY: Dose response counterscreen for antagonists of galanin receptor 2 (GalR2): a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity. (Class of assay: confirmatory) [Related pubchem assays: 828, 1225, 866 ]
ChEMBL 252 3 0 7 2.0 O=[N+]([O-])c1cc(-c2ncccn2)c([N+](=O)[O-])s1 nan
11417 3591 0 None 3 2 Human 6.8 pEC50 = 6.8 Functional
Determined by measuring SRE-luc activity in HEK293-Gqi cells expressing hGALR2.Determined by measuring SRE-luc activity in HEK293-Gqi cells expressing hGALR2.
Guide to Pharmacology None None None None 24517231
8547 1266 0 None - 1 Rat 9.2 pEC50 = 9.2 Functional
Potentiation of galanin-induced IP1 accumulation <i>in vitro</i>.Potentiation of galanin-induced IP1 accumulation <i>in vitro</i>.
Guide to Pharmacology 765 13 5 7 7.3 O=C(N[C@H](C(=O)N[C@H](C(=O)Nc1ccc2c(c1)[nH]c(=O)cc2C)CCCNC(=O)OC(C)(C)C)CC1CCCCC1)OCC1C2C=CC=CC2c2c1cccc2 20660766
91827369 1266 0 None - 1 Rat 9.2 pEC50 = 9.2 Functional
Potentiation of galanin-induced IP1 accumulation <i>in vitro</i>.Potentiation of galanin-induced IP1 accumulation <i>in vitro</i>.
Guide to Pharmacology 765 13 5 7 7.3 O=C(N[C@H](C(=O)N[C@H](C(=O)Nc1ccc2c(c1)[nH]c(=O)cc2C)CCCNC(=O)OC(C)(C)C)CC1CCCCC1)OCC1C2C=CC=CC2c2c1cccc2 20660766
11419 3213 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
SRE-luc reporter activation in HEK293 Gqi cells expressing hGAL<sub>3</sub> receptor.SRE-luc reporter activation in HEK293 Gqi cells expressing hGAL<sub>3</sub> receptor.
Guide to Pharmacology None None None None 32231393
6095 1709 0 None -2 2 Human 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
3896 2410 0 None -58 4 Rat 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
6095 1709 0 None 2 2 Rat 6.8 pEC50 = 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
16132180 1694 14 None -89 4 Rat 7.0 pEC50 = 7.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
16133822 1694 14 None -89 4 Rat 7.0 pEC50 = 7.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
6087 1694 14 None -89 4 Rat 7.0 pEC50 = 7.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
CHEMBL499980 1694 14 None -89 4 Rat 7.0 pEC50 = 7.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
16131409 1693 0 None -16 3 Rat 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
6086 1693 0 None -16 3 Rat 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
155817479 1706 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6083 1706 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
3898 2413 0 None -562 4 Rat 7.5 pEC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
3899 2414 0 None -15 4 Rat 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
155817484 1686 0 None -42 5 Rat 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
6117 1686 0 None -42 5 Rat 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
6129 1686 0 None -42 5 Rat 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
3899 2414 0 None -32 4 Human 7.8 pEC50 = 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
155817463 765 0 None -3 4 Human 8.0 pEC50 = 8.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
3861 765 0 None -3 4 Human 8.0 pEC50 = 8.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
155817484 1686 0 None -25 5 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6117 1686 0 None -25 5 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6129 1686 0 None -25 5 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
3897 2412 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
3897 2412 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
155817487 1699 0 None 9 2 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
155817487 1699 0 None 9 2 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6130 1699 0 None 9 2 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
6130 1699 0 None 9 2 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
16133243 1684 0 None -17 5 Rat 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10601261
3593 1684 0 None -17 5 Rat 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10601261
16132180 1694 14 None -12 4 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
16132180 1694 14 None -12 4 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
16133822 1694 14 None -12 4 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
16133822 1694 14 None -12 4 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6087 1694 14 None -12 4 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
6087 1694 14 None -12 4 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
CHEMBL499980 1694 14 None -12 4 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
CHEMBL499980 1694 14 None -12 4 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
3898 2413 0 None -316 4 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
3898 2413 0 None -316 4 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
155817463 765 0 None -2 4 Rat 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
3861 765 0 None -2 4 Rat 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
101927062 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
101927062 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
155817445 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
155817445 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
16133823 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
16133823 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
3592 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
3592 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
44584852 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
44584852 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6090 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
6090 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
91898917 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
91898917 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
CHEMBL506553 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
CHEMBL506553 1685 21 None -24 5 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
3896 2410 0 None -3 4 Human 8.6 pEC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
3896 2410 0 None -3 4 Human 8.6 pEC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
3896 2410 0 None -3 4 Human 8.6 pEC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6120 1712 0 None 15 2 Rat 8.6 pEC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10601261
16131409 1693 0 None 1 3 Human 9.1 pEC50 = 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
6086 1693 0 None 1 3 Human 9.1 pEC50 = 9.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
155817483 1687 0 None 1 2 Human 6.0 pEC50 > 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
6094 1687 0 None 1 2 Human 6.0 pEC50 > 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
155817480 1701 0 None -1 3 Human 6.0 pEC50 > 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
155817480 1701 0 None -1 3 Rat 6.0 pEC50 > 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
6091 1701 0 None -1 3 Human 6.0 pEC50 > 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6091 1701 0 None -1 3 Rat 6.0 pEC50 > 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
155817483 1687 0 None -1 2 Rat 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
6094 1687 0 None -1 2 Rat 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
155817475 1704 0 None - 1 Rat 6.7 pIC50 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7683428
5359 1704 0 None - 1 Rat 6.7 pIC50 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7683428
155817485 1727 0 None 1 2 Human 7.2 pIC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15944009
6121 1727 0 None 1 2 Human 7.2 pIC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15944009
3594 1711 0 None -2 3 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15944009
3594 1711 0 None -2 3 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20880399
134813891 1728 0 None 2 2 Human 7.8 pIC50 = 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15944009
6122 1728 0 None 2 2 Human 7.8 pIC50 = 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15944009
3896 2410 0 None -58 4 Rat 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
3896 2410 0 None -58 4 Rat 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
155817463 765 0 None -2 4 Rat 8.0 pIC50 = 8.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
155817463 765 0 None -2 4 Rat 8.0 pIC50 = 8.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
3861 765 0 None -2 4 Rat 8.0 pIC50 = 8.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
3861 765 0 None -2 4 Rat 8.0 pIC50 = 8.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
155817463 765 0 None -3 4 Human 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
3861 765 0 None -3 4 Human 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
16131409 1693 0 None -16 3 Rat 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
6086 1693 0 None -16 3 Rat 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
16132180 1694 14 None -89 4 Rat 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
16132180 1694 14 None -89 4 Rat 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
16133822 1694 14 None -89 4 Rat 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
16133822 1694 14 None -89 4 Rat 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
6087 1694 14 None -89 4 Rat 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
6087 1694 14 None -89 4 Rat 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
CHEMBL499980 1694 14 None -89 4 Rat 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
CHEMBL499980 1694 14 None -89 4 Rat 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
3896 2410 0 None -3 4 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
16133243 1684 0 None -7 5 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
16133243 1684 0 None -7 5 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
3593 1684 0 None -7 5 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
3593 1684 0 None -7 5 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
155817465 1700 0 None 2 3 Rat 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
3876 1700 0 None 2 3 Rat 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
16131409 1693 0 None 1 3 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
6086 1693 0 None 1 3 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
3899 2414 0 None -15 4 Rat 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
3899 2414 0 None -15 4 Rat 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
16132180 1694 14 None -12 4 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
16133822 1694 14 None -12 4 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
6087 1694 14 None -12 4 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
CHEMBL499980 1694 14 None -12 4 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
155817487 1699 0 None 9 2 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
155817487 1699 0 None 9 2 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
6130 1699 0 None 9 2 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
6130 1699 0 None 9 2 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
155817474 1698 0 None 489 2 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11481429
5357 1698 0 None 489 2 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11481429
6082 3426 0 None -4 2 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11481429
155817473 1690 0 None -1 2 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11481429
5356 1690 0 None -1 2 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11481429
6084 1690 0 None -1 2 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11481429
101927062 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11481429
101927062 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
101927062 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
155817445 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11481429
155817445 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
155817445 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
16133823 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11481429
16133823 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
16133823 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
3592 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11481429
3592 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
3592 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
44584852 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11481429
44584852 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
44584852 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
6090 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11481429
6090 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
6090 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
91898917 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11481429
91898917 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
91898917 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
CHEMBL506553 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11481429
CHEMBL506553 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
CHEMBL506553 1685 21 None -24 5 Rat 8.8 pIC50 = 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
3898 2413 0 None -562 4 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
3898 2413 0 None -562 4 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
16133243 1684 0 None -17 5 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10601261
16133243 1684 0 None -17 5 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20880399
16133243 1684 0 None -17 5 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
3593 1684 0 None -17 5 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10601261
3593 1684 0 None -17 5 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20880399
3593 1684 0 None -17 5 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
101927062 1685 21 None -24 5 Human 9.3 pIC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
155817445 1685 21 None -24 5 Human 9.3 pIC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
16133823 1685 21 None -24 5 Human 9.3 pIC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
3592 1685 21 None -24 5 Human 9.3 pIC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
44584852 1685 21 None -24 5 Human 9.3 pIC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
6090 1685 21 None -24 5 Human 9.3 pIC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
91898917 1685 21 None -24 5 Human 9.3 pIC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
CHEMBL506553 1685 21 None -24 5 Human 9.3 pIC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
155817484 1686 0 None -42 5 Rat 9.4 pIC50 = 9.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
155817484 1686 0 None -42 5 Rat 9.4 pIC50 = 9.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
6117 1686 0 None -42 5 Rat 9.4 pIC50 = 9.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
6117 1686 0 None -42 5 Rat 9.4 pIC50 = 9.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
6129 1686 0 None -42 5 Rat 9.4 pIC50 = 9.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
6129 1686 0 None -42 5 Rat 9.4 pIC50 = 9.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
155817484 1686 0 None -25 5 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
6117 1686 0 None -25 5 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
6129 1686 0 None -25 5 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
16133243 1684 0 None -7 5 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
3593 1684 0 None -7 5 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
6120 1712 0 None 15 2 Rat 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10601261
6124 1411 1 None -158 2 Human 4.5 pIC50 > 4.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 286 1 0 4 1.5 Cc1ccc(cc1)C1=CS(=O)(=O)CCCS1(=O)=O 10896115
9947811 1411 1 None -158 2 Human 4.5 pIC50 > 4.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 286 1 0 4 1.5 Cc1ccc(cc1)C1=CS(=O)(=O)CCCS1(=O)=O 10896115
CHEMBL3906195 1411 1 None -158 2 Human 4.5 pIC50 > 4.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 286 1 0 4 1.5 Cc1ccc(cc1)C1=CS(=O)(=O)CCCS1(=O)=O 10896115
131863305 324 0 None -1 3 Rat 6.0 pIC50 > 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20880399
155817486 324 0 None -1 3 Rat 6.0 pIC50 > 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20880399
6123 324 0 None -1 3 Rat 6.0 pIC50 > 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20880399
155817480 1701 0 None -1 3 Human 6.0 pIC50 > 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
155817480 1701 0 None -1 3 Human 6.0 pIC50 > 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
6091 1701 0 None -1 3 Human 6.0 pIC50 > 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
6091 1701 0 None -1 3 Human 6.0 pIC50 > 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
155817481 1702 0 None -1 3 Rat 6.0 pIC50 > 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306
6092 1702 0 None -1 3 Rat 6.0 pIC50 > 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9108306




Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Affinity)
# tested GPCRs
(Affinity)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
72548703 161019 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]-endothelin-1 from human recombinant GAL2 receptor after 120 mins by scintillation counting analysisDisplacement of [125I]-endothelin-1 from human recombinant GAL2 receptor after 120 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
CHEMBL4128926 161019 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]-endothelin-1 from human recombinant GAL2 receptor after 120 mins by scintillation counting analysisDisplacement of [125I]-endothelin-1 from human recombinant GAL2 receptor after 120 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
CHEMBL501079 212359 10 None -11 2 Human 9.1 pIC50 = 9.1 Binding
Binding affinity to human GAL2 receptor by radioligand displacement assayBinding affinity to human GAL2 receptor by radioligand displacement assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O 10.1016/j.bmc.2013.03.016
57392517 68462 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 473 8 3 7 6.6 COc1ccc(Nc2cc(Nc3ccc(OC(F)(F)F)cc3)nc(NC3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1921997 68462 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 473 8 3 7 6.6 COc1ccc(Nc2cc(Nc3ccc(OC(F)(F)F)cc3)nc(NC3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57396058 68401 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 375 6 2 6 5.0 COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1921902 68401 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 375 6 2 6 5.0 COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57401222 68470 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 403 6 2 6 5.6 COc1ccc(Nc2nc(Nc3ccc(C)cc3C)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922004 68470 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 403 6 2 6 5.6 COc1ccc(Nc2nc(Nc3ccc(C)cc3C)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57395993 68460 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 455 9 3 7 6.3 COc1ccc(Nc2cc(Nc3ccc(OC(F)F)cc3)nc(NC3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1921995 68460 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 455 9 3 7 6.3 COc1ccc(Nc2cc(Nc3ccc(OC(F)F)cc3)nc(NC3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57401225 68483 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 437 7 2 7 5.4 COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCC(C)C3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922019 68483 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 437 7 2 7 5.4 COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCC(C)C3)n2)cc1 10.1016/j.bmcl.2011.09.033
57394237 68463 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 419 8 3 7 5.7 COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(NC3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1921998 68463 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 419 8 3 7 5.7 COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(NC3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57397798 68466 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 527 6 1 8 5.4 COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922000 68466 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 527 6 1 8 5.4 COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57392518 68477 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 457 7 2 6 5.9 COc1ccc(Nc2nc(NCc3cccc(C(F)(F)F)c3)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922011 68477 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 457 7 2 6 5.9 COc1ccc(Nc2nc(NCc3cccc(C(F)(F)F)c3)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL501079 212359 10 None -11 2 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to human GAL2 receptor by radioligand displacement assayBinding affinity to human GAL2 receptor by radioligand displacement assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O 10.1016/j.ejmech.2013.01.044
101927062 1685 21 None -8 6 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
155817445 1685 21 None -8 6 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
16133823 1685 21 None -8 6 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
3592 1685 21 None -8 6 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
44584852 1685 21 None -8 6 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
6090 1685 21 None -8 6 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
91898917 1685 21 None -8 6 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
CHEMBL506553 1685 21 None -8 6 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]galanin from human recombinant GAL2 receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
57399458 68468 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 545 6 1 8 5.5 COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1F 10.1016/j.bmcl.2011.09.033
CHEMBL1922002 68468 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 545 6 1 8 5.5 COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1F 10.1016/j.bmcl.2011.09.033
57395994 68467 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 525 5 1 7 6.0 Cc1ccc(C)c(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)c1 10.1016/j.bmcl.2011.09.033
CHEMBL1922001 68467 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 525 5 1 7 6.0 Cc1ccc(C)c(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)c1 10.1016/j.bmcl.2011.09.033
16078939 180130 15 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
ChEMBL 395 9 2 4 3.9 N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(=O)O 10.1016/j.bmcl.2008.10.104
CHEMBL475562 180130 15 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
ChEMBL 395 9 2 4 3.9 N[C@@H](COC(c1cccc(F)c1)c1ccccc1OCc1ccccc1)C(=O)O 10.1016/j.bmcl.2008.10.104
CHEMBL514318 213819 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]([C@@H](C)CC)NC1=O 10.1016/j.bmcl.2008.10.104
CHEMBL475845 212284 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](CS(=O)(=O)O)C(C)=O)NC(=O)[C@H]([C@@H](C)CC)NC1=O 10.1016/j.bmcl.2008.10.104
57390718 68486 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 500 8 2 8 5.4 COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCN(c4ccccc4)CC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922023 68486 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 500 8 2 8 5.4 COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCN(c4ccccc4)CC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL515145 213821 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC(=O)[C@H]([C@@H](C)CC)NC1=O 10.1016/j.bmcl.2008.10.104
57401223 68482 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 411 9 2 7 5.0 CCN(CC)c1cc(Nc2ccc(OC)c(F)c2)nc(Nc2ccc(OC)cc2)n1 10.1016/j.bmcl.2011.09.033
CHEMBL1922017 68482 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 411 9 2 7 5.0 CCN(CC)c1cc(Nc2ccc(OC)c(F)c2)nc(Nc2ccc(OC)cc2)n1 10.1016/j.bmcl.2011.09.033
CHEMBL501079 212359 10 None -11 2 Human 8.5 pIC50 = 8.5 Binding
Displacement of radiolabeled galanin from human galanin 2 receptorDisplacement of radiolabeled galanin from human galanin 2 receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O 10.1021/jm8007618
CHEMBL501079 212359 10 None -11 2 Human 8.5 pIC50 = 8.5 Binding
Inhibition of human GAL2 receptorInhibition of human GAL2 receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O 10.1021/jm701575k
54764411 68473 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 459 7 2 7 5.9 COc1ccc(Nc2nc(Nc3ccc(OC(F)(F)F)cc3)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922007 68473 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 459 7 2 7 5.9 COc1ccc(Nc2nc(Nc3ccc(OC(F)(F)F)cc3)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57394235 68453 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 411 7 2 6 5.6 FC(F)Oc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1921988 68453 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 411 7 2 6 5.6 FC(F)Oc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57399456 68457 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 430 6 1 7 4.2 COc1ccc(Nc2cc(N3CCN(c4ccccc4)CC3)nc(N3CCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1921992 68457 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 430 6 1 7 4.2 COc1ccc(Nc2cc(N3CCN(c4ccccc4)CC3)nc(N3CCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57397796 68455 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 403 6 2 7 4.6 c1ccc(Nc2cc(NCc3ccc4c(c3)OCO4)nc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1921990 68455 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 403 6 2 7 4.6 c1ccc(Nc2cc(NCc3ccc4c(c3)OCO4)nc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
54764328 68472 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 459 7 2 7 5.9 COc1ccc(Nc2nc(Nc3cccc(OC(F)(F)F)c3)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922006 68472 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 459 7 2 7 5.9 COc1ccc(Nc2nc(Nc3cccc(OC(F)(F)F)c3)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
54764412 68479 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 407 6 2 6 5.4 COc1ccc(Nc2nc(Nc3cccc(F)c3C)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922013 68479 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 407 6 2 6 5.4 COc1ccc(Nc2nc(Nc3cccc(F)c3C)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57401220 68454 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 411 7 2 6 5.6 FC(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 10.1016/j.bmcl.2011.09.033
CHEMBL1921989 68454 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 411 7 2 6 5.6 FC(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 10.1016/j.bmcl.2011.09.033
57394241 68480 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 427 6 2 6 5.8 COc1ccc(Nc2nc(Nc3ccc(F)c(Cl)c3)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922014 68480 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 427 6 2 6 5.8 COc1ccc(Nc2nc(Nc3ccc(F)c(Cl)c3)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57394240 68476 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 423 7 2 7 5.1 COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922010 68476 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 423 7 2 7 5.1 COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57397799 68471 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 403 6 2 6 5.6 COc1ccc(Nc2nc(Nc3cc(C)ccc3C)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922005 68471 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 403 6 2 6 5.6 COc1ccc(Nc2nc(Nc3cc(C)ccc3C)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL474037 212274 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC1=O 10.1016/j.bmcl.2008.10.104
57394303 68400 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 373 5 2 5 5.6 Cc1ccc(C)c(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 10.1016/j.bmcl.2011.09.033
CHEMBL1921901 68400 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 373 5 2 5 5.6 Cc1ccc(C)c(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 10.1016/j.bmcl.2011.09.033
57394239 68475 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 441 8 2 7 5.6 COc1ccc(Nc2nc(Nc3cccc(OC(F)F)c3)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922009 68475 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 441 8 2 7 5.6 COc1ccc(Nc2nc(Nc3cccc(OC(F)F)c3)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL474038 212275 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
ChEMBL None None None CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC(=O)[C@H](C(C)C)NC1=O 10.1016/j.bmcl.2008.10.104
57399457 68464 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 473 8 3 7 6.6 COc1ccc(Nc2cc(Nc3cccc(OC(F)(F)F)c3)nc(NC3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1921999 68464 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 473 8 3 7 6.6 COc1ccc(Nc2cc(Nc3cccc(OC(F)(F)F)c3)nc(NC3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57394238 68469 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 529 5 1 7 5.8 Cc1c(F)cccc1Nc1cc(N2CCCCC2)nc(N2CCCN(c3ncccc3C(F)(F)F)CC2)n1 10.1016/j.bmcl.2011.09.033
CHEMBL1922003 68469 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 529 5 1 7 5.8 Cc1c(F)cccc1Nc1cc(N2CCCCC2)nc(N2CCCN(c3ncccc3C(F)(F)F)CC2)n1 10.1016/j.bmcl.2011.09.033
CHEMBL473840 212273 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC(=O)[C@H](C(C)C)NC1=O 10.1016/j.bmcl.2008.10.104
57394304 68402 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 429 6 2 6 5.9 FC(F)(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 10.1016/j.bmcl.2011.09.033
CHEMBL1921903 68402 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 429 6 2 6 5.9 FC(F)(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 10.1016/j.bmcl.2011.09.033
57401221 68461 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 455 9 3 7 6.3 COc1ccc(Nc2cc(Nc3cccc(OC(F)F)c3)nc(NC3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1921996 68461 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 455 9 3 7 6.3 COc1ccc(Nc2cc(Nc3cccc(OC(F)F)c3)nc(NC3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57390716 68481 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 437 7 2 7 5.5 COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922016 68481 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 437 7 2 7 5.5 COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57399459 68474 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 443 6 2 6 6.0 COc1ccc(Nc2nc(Nc3ccc(C(F)(F)F)cc3)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922008 68474 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 443 6 2 6 6.0 COc1ccc(Nc2nc(Nc3ccc(C(F)(F)F)cc3)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57397797 68459 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 391 7 2 7 4.6 COc1ccc(Nc2cc(Nc3ccc(OC)cc3)nc(N3CCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1921994 68459 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 391 7 2 7 4.6 COc1ccc(Nc2cc(Nc3ccc(OC)cc3)nc(N3CCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57395992 68456 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 393 6 2 6 5.1 COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1F 10.1016/j.bmcl.2011.09.033
CHEMBL1921991 68456 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 393 6 2 6 5.1 COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1F 10.1016/j.bmcl.2011.09.033
CHEMBL451169 212216 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cellsInhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCC(C)=O)NC(=O)[C@H]2CCCCN2C1=O 10.1016/j.bmcl.2008.10.104
57401228 68488 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 538 7 2 9 5.6 COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCN(C(=O)OC(C)(C)C)CC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922025 68488 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 538 7 2 9 5.6 COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCN(C(=O)OC(C)(C)C)CC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57394236 68458 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 391 7 2 7 4.6 COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(N3CCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1921993 68458 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 391 7 2 7 4.6 COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(N3CCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
57395995 68478 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 407 6 2 6 5.4 COc1ccc(Nc2nc(Nc3ccc(F)cc3C)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL1922012 68478 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]galanin from GalR2 by gamma countingDisplacement of [125I]galanin from GalR2 by gamma counting
ChEMBL 407 6 2 6 5.4 COc1ccc(Nc2nc(Nc3ccc(F)cc3C)cc(N3CCCCC3)n2)cc1 10.1016/j.bmcl.2011.09.033
CHEMBL526003 213893 24 None -10 3 Human 9.0 pKd = 9 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(N)=O 10.1021/jm801088x
CHEMBL506210 212434 0 None 478 2 Human 8.7 pKd = 8.7 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None None 10.1021/jm801088x
CHEMBL503473 212396 13 None -60 3 Human 8.7 pKd = 8.7 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O 10.1021/jm801088x
155817464 1471 0 None -5 4 Human 8.6 pKd = 8.6 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None None 10.1021/jm801088x
3866 1471 0 None -5 4 Human 8.6 pKd = 8.6 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None None 10.1021/jm801088x
44587986 1471 0 None -5 4 Human 8.6 pKd = 8.6 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None None 10.1021/jm801088x
91934870 1471 0 None -5 4 Human 8.6 pKd = 8.6 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None None 10.1021/jm801088x
CHEMBL499179 1471 0 None -5 4 Human 8.6 pKd = 8.6 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None None 10.1021/jm801088x
71717271 85663 1 None -1 3 Human 4.6 pKd = 4.6 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL 678 13 4 7 6.5 Cc1cc(=O)oc2cc(NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12 10.1021/jm801088x
CHEMBL2309599 85663 1 None -1 3 Human 4.6 pKd = 4.6 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL 678 13 4 7 6.5 Cc1cc(=O)oc2cc(NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12 10.1021/jm801088x
16132180 1694 14 None -3 8 Human 8.3 pKd = 8.3 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None None 10.1021/jm801088x
16133822 1694 14 None -3 8 Human 8.3 pKd = 8.3 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None None 10.1021/jm801088x
6087 1694 14 None -3 8 Human 8.3 pKd = 8.3 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None None 10.1021/jm801088x
CHEMBL499980 1694 14 None -3 8 Human 8.3 pKd = 8.3 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None None 10.1021/jm801088x
CHEMBL604373 214045 3 None -7 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(N)=O 10.1021/jm9018349
CHEMBL501079 212359 10 None -11 2 Human 9.1 pKi = 9.1 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O 10.1021/jm9018349
CHEMBL526003 213893 24 None -10 3 Human 9.0 pKi = 9.0 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(N)=O 10.1021/jm9018349
CHEMBL592413 214032 0 None -4 2 Human 8.9 pKi = 8.9 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O 10.1021/jm9018349
CHEMBL604990 214047 20 None -15 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](C)C(N)=O 10.1021/jm9018349
CHEMBL578710 214001 20 None 501 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(N)=O 10.1021/jm9018349
CHEMBL503473 212396 13 None -60 3 Human 8.7 pKi = 8.7 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O 10.1021/jm9018349
25180488 187782 0 None -4 2 Human 7.0 pKi = 7.0 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2111 78 26 26 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
CHEMBL501306 187782 0 None -4 2 Human 7.0 pKi = 7.0 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2111 78 26 26 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
CHEMBL2324949 207782 0 None -3 2 Human 6.9 pKi = 6.9 Binding
Displacement of euporium-galanin from human GalR2 after 1.5 hrs by DELFIA assayDisplacement of euporium-galanin from human GalR2 after 1.5 hrs by DELFIA assay
ChEMBL None None None CNCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@]1(C)CCC/C=C/CCC[C@@](C)(C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CNC1=O)[C@@H](C)O 10.1016/j.bmc.2012.10.026
CHEMBL508083 212936 0 None -25 2 Human 7.9 pKi = 7.9 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)N[C@H](C(N)=O)C(C)C 10.1021/jm801088x
25180498 192753 0 None -4 2 Human 5.9 pKi = 5.9 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 1957 75 25 24 0.3 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
CHEMBL524892 192753 0 None -4 2 Human 5.9 pKi = 5.9 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 1957 75 25 24 0.3 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
44563953 176226 0 None -11 2 Human 7.8 pKi = 7.8 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 2028 72 25 27 -2.5 CCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801397w
CHEMBL460706 176226 0 None -11 2 Human 7.8 pKi = 7.8 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 2028 72 25 27 -2.5 CCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801397w
44563952 188093 0 None -20 2 Human 7.8 pKi = 7.8 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 2000 70 25 27 -3.2 CCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801397w
CHEMBL503900 188093 0 None -20 2 Human 7.8 pKi = 7.8 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 2000 70 25 27 -3.2 CCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801397w
44563957 172173 0 None -3 2 Human 7.8 pKi = 7.8 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 2140 80 25 27 0.7 CCCCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801397w
CHEMBL450827 172173 0 None -3 2 Human 7.8 pKi = 7.8 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 2140 80 25 27 0.7 CCCCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801397w
25180491 192848 0 None -16 2 Human 7.8 pKi = 7.8 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2111 78 26 26 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCCN)NC(=O)[C@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
CHEMBL526500 192848 0 None -16 2 Human 7.8 pKi = 7.8 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2111 78 26 26 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCCN)NC(=O)[C@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
CHEMBL2324950 207783 0 None -4 2 Human 7.8 pKi = 7.8 Binding
Displacement of euporium-galanin from human GalR2 after 1.5 hrs by DELFIA assayDisplacement of euporium-galanin from human GalR2 after 1.5 hrs by DELFIA assay
ChEMBL None None None CNCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@]1(C)CCC/C=C\CCC[C@@](C)(C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)O 10.1016/j.bmc.2012.10.026
45104656 196895 0 None -9 2 Human 7.8 pKi = 7.8 Binding
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
ChEMBL 2082 76 25 25 0.3 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm9018349
CHEMBL578317 196895 0 None -9 2 Human 7.8 pKi = 7.8 Binding
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
ChEMBL 2082 76 25 25 0.3 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm9018349
44563954 188325 0 None -11 2 Human 7.8 pKi = 7.8 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 2056 74 25 27 -1.7 CCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801397w
CHEMBL507733 188325 0 None -11 2 Human 7.8 pKi = 7.8 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 2056 74 25 27 -1.7 CCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801397w
25180486 192867 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 1935 66 23 23 -0.4 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O 10.1021/jm801088x
44587983 192867 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 1935 66 23 23 -0.4 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O 10.1021/jm801088x
CHEMBL526862 192867 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 1935 66 23 23 -0.4 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O 10.1021/jm801088x
25180489 187677 0 None -5 2 Human 7.8 pKi = 7.8 Binding
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
ChEMBL 2097 77 26 26 -0.8 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm9018349
CHEMBL499807 187677 0 None -5 2 Human 7.8 pKi = 7.8 Binding
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
ChEMBL 2097 77 26 26 -0.8 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm9018349
44563955 192739 0 None -7 2 Human 7.7 pKi = 7.7 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 2084 76 25 27 -0.9 CCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801397w
CHEMBL524678 192739 0 None -7 2 Human 7.7 pKi = 7.7 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 2084 76 25 27 -0.9 CCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801397w
CHEMBL501079 212359 10 None -11 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to human GAL2 receptor by radioligand displacement assayBinding affinity to human GAL2 receptor by radioligand displacement assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O 10.1016/j.ejmech.2013.01.044
45104657 199776 0 None 18 2 Human 7.7 pKi = 7.7 Binding
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
ChEMBL 2054 76 25 25 0.3 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm9018349
CHEMBL604991 199776 0 None 18 2 Human 7.7 pKi = 7.7 Binding
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
ChEMBL 2054 76 25 25 0.3 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm9018349
44563958 188167 0 None -40 2 Human 7.7 pKi = 7.7 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 2122 78 25 32 -5.9 CNCC(=O)O[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCNC(=O)COCCOCCOCCOCCOC)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O 10.1021/jm801397w
CHEMBL505299 188167 0 None -40 2 Human 7.7 pKi = 7.7 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 2122 78 25 32 -5.9 CNCC(=O)O[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCNC(=O)COCCOCCOCCOCCOC)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O 10.1021/jm801397w
25180497 192869 0 None -5 2 Human 6.7 pKi = 6.7 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2213 87 29 28 -0.4 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
CHEMBL526889 192869 0 None -5 2 Human 6.7 pKi = 6.7 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2213 87 29 28 -0.4 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
CHEMBL592170 214031 0 None 2 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(N)=O)[C@@H](C)O 10.1021/jm9018349
25180487 192799 0 None -11 2 Human 7.7 pKi = 7.7 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2111 78 26 26 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O 10.1021/jm801088x
CHEMBL525755 192799 0 None -11 2 Human 7.7 pKi = 7.7 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2111 78 26 26 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O 10.1021/jm801088x
25180489 187677 0 None -5 2 Human 7.7 pKi = 7.7 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2097 77 26 26 -0.8 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
CHEMBL499807 187677 0 None -5 2 Human 7.7 pKi = 7.7 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2097 77 26 26 -0.8 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
44563951 188350 0 None -60 2 Human 7.6 pKi = 7.6 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 1874 63 25 27 -5.8 CNCC(=O)O[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O 10.1021/jm801397w
CHEMBL508036 188350 0 None -60 2 Human 7.6 pKi = 7.6 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 1874 63 25 27 -5.8 CNCC(=O)O[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O 10.1021/jm801397w
CHEMBL525055 213858 0 None -60 2 Human 7.6 pKi = 7.6 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL None None None CNCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O 10.1021/jm801088x
25180494 188144 0 None -4 2 Human 7.6 pKi = 7.6 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2111 78 26 26 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
CHEMBL504914 188144 0 None -4 2 Human 7.6 pKi = 7.6 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2111 78 26 26 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
CHEMBL501079 212359 10 None -11 2 Human 8.5 pKi = 8.5 Binding
Displacement of radiolabeled galanin from human galanin 2 receptorDisplacement of radiolabeled galanin from human galanin 2 receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O 10.1021/jm8007618
71717271 85663 1 None -2 3 Rat 4.5 pKi = 4.5 Binding
Binding affinity to rat GalR2Binding affinity to rat GalR2
ChEMBL 678 13 4 7 6.5 Cc1cc(=O)oc2cc(NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12 10.1021/jm9018349
CHEMBL2309599 85663 1 None -2 3 Rat 4.5 pKi = 4.5 Binding
Binding affinity to rat GalR2Binding affinity to rat GalR2
ChEMBL 678 13 4 7 6.5 Cc1cc(=O)oc2cc(NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12 10.1021/jm9018349
45104655 196950 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
ChEMBL 2111 77 26 26 -0.4 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm9018349
CHEMBL578910 196950 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
ChEMBL 2111 77 26 26 -0.4 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm9018349
25180495 188245 0 None 8 2 Human 7.3 pKi = 7.3 Binding
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
ChEMBL 2040 75 25 25 0.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm9018349
CHEMBL506495 188245 0 None 8 2 Human 7.3 pKi = 7.3 Binding
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
ChEMBL 2040 75 25 25 0.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm9018349
25180495 188245 0 None 8 2 Human 7.3 pKi = 7.3 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2040 75 25 25 0.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
CHEMBL506495 188245 0 None 8 2 Human 7.3 pKi = 7.3 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2040 75 25 25 0.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
25180496 188135 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2153 81 26 26 0.8 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
CHEMBL504758 188135 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2153 81 26 26 0.8 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
24760995 196910 0 None -14 2 Human 7.3 pKi = 7.3 Binding
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
ChEMBL 2112 78 26 26 0.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm9018349
CHEMBL578514 196910 0 None -14 2 Human 7.3 pKi = 7.3 Binding
Displacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assayDisplacement of Eu-labeled galanin from human GalR2 by DELFIA competitive assay
ChEMBL 2112 78 26 26 0.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm9018349
44563956 188302 0 None -14 2 Human 7.3 pKi = 7.3 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 2112 78 25 27 -0.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801397w
CHEMBL507353 188302 0 None -14 2 Human 7.3 pKi = 7.3 Binding
Displacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assayDisplacement of europium labeled galanin from human recombinant GalR2 receptor by time-resolved fluorescence binding assay
ChEMBL 2112 78 25 27 -0.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801397w
44587984 192761 1 None -14 2 Human 7.3 pKi = 7.3 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2111 78 26 26 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
CHEMBL525023 192761 1 None -14 2 Human 7.3 pKi = 7.3 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2111 78 26 26 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
24760995 196910 0 None -14 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL 2112 78 26 26 0.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm9018349
CHEMBL578514 196910 0 None -14 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL 2112 78 26 26 0.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm9018349
25180490 62855 0 None -19 2 Human 7.2 pKi = 7.2 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2195 78 32 26 -3.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O 10.1021/jm801088x
91934869 62855 0 None -19 2 Human 7.2 pKi = 7.2 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2195 78 32 26 -3.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O 10.1021/jm801088x
CHEMBL1790054 62855 0 None -19 2 Human 7.2 pKi = 7.2 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2195 78 32 26 -3.1 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O 10.1021/jm801088x
25180492 188304 0 None -2 2 Human 7.1 pKi = 7.1 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2014 77 26 25 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
CHEMBL507373 188304 0 None -2 2 Human 7.1 pKi = 7.1 Binding
Displacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cellsDisplacement of europium-labeled galanin from human GalR2 expressed in CHO-K1 cells
ChEMBL 2014 77 26 25 -0.5 CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O 10.1021/jm801088x
CHEMBL592415 214033 0 None 5 2 Human 8.0 pKi = 8.0 Binding
Binding affinity to human GalR2Binding affinity to human GalR2
ChEMBL None None None None 10.1021/jm9018349
155817484 1686 0 None -3 6 Rat 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
155817484 1686 0 None -3 6 Rat 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
155817484 1686 0 None -3 6 Rat 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9578584
155817484 1686 0 None -3 6 Rat 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
6117 1686 0 None -3 6 Rat 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
6117 1686 0 None -3 6 Rat 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
6117 1686 0 None -3 6 Rat 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9578584
6117 1686 0 None -3 6 Rat 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
6129 1686 0 None -3 6 Rat 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
6129 1686 0 None -3 6 Rat 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9427506
6129 1686 0 None -3 6 Rat 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9578584
6129 1686 0 None -3 6 Rat 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
155817484 1686 0 None -1 6 Human 9.5 pKd = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6117 1686 0 None -1 6 Human 9.5 pKd = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6129 1686 0 None -1 6 Human 9.5 pKd = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
155817484 1686 0 None -1 6 Human 9.9 pKd = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
6117 1686 0 None -1 6 Human 9.9 pKd = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
6129 1686 0 None -1 6 Human 9.9 pKd = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9685625
24748735 1725 1 None 3 2 Rat 5.0 pKd > 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 988 12 7 15 4.2 NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 15240875
24748735 1725 1 None 3 2 Rat 5.0 pKd > 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 988 12 7 15 4.2 NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 15944002
6119 1725 1 None 3 2 Rat 5.0 pKd > 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 988 12 7 15 4.2 NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 15240875
6119 1725 1 None 3 2 Rat 5.0 pKd > 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 988 12 7 15 4.2 NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 15944002
CHEMBL1187471 1725 1 None 3 2 Rat 5.0 pKd > 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 988 12 7 15 4.2 NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 15240875
CHEMBL1187471 1725 1 None 3 2 Rat 5.0 pKd > 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 988 12 7 15 4.2 NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 15944002
16131409 1693 0 125I-GALANIN 4 3 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase None None None None None
6086 1693 0 125I-GALANIN 4 3 Rat 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase None None None None None
None 214290 0 125I-h Galanin -1 6 Rat 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 418 8 0 4 4.3 CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl None
None 214290 0 125I-GALANIN -1 6 Rat 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 418 8 0 4 4.3 CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl None
None 214290 0 125I-GALANIN 1 6 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 418 8 0 4 4.3 CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl None
None 214290 0 125I-p Galanin -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 418 8 0 4 4.3 CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl None
None 214290 0 125I-h Galanin -1 6 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 418 8 0 4 4.3 CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl None
None 214290 0 125I-GALANIN -1 6 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 418 8 0 4 4.3 CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl None
None 214290 0 125I-GALANIN -1 6 Rat 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 418 8 0 4 4.3 CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl None
5311268 1726 0 None -2 2 Rat 4.5 pKi = 4.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 678 13 4 7 6.5 NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 15240875
5311268 1726 0 None -2 2 Rat 4.5 pKi = 4.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 678 13 4 7 6.5 NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 15944002
6118 1726 0 None -2 2 Rat 4.5 pKi = 4.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 678 13 4 7 6.5 NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 15240875
6118 1726 0 None -2 2 Rat 4.5 pKi = 4.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 678 13 4 7 6.5 NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 15944002
CHEMBL592414 1726 0 None -2 2 Rat 4.5 pKi = 4.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 678 13 4 7 6.5 NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 15240875
CHEMBL592414 1726 0 None -2 2 Rat 4.5 pKi = 4.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 678 13 4 7 6.5 NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 15944002
155817481 1702 0 None -2 6 Rat 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9405385
155817481 1702 0 None -2 6 Rat 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9742938
155817481 1702 0 None -2 6 Rat 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
6092 1702 0 None -2 6 Rat 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9405385
6092 1702 0 None -2 6 Rat 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9742938
6092 1702 0 None -2 6 Rat 5.8 pKi = 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
6095 1709 0 None -14 6 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
155817474 1698 0 None -5 5 Rat 7.1 pKi = 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15944007
5357 1698 0 None -5 5 Rat 7.1 pKi = 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15944007
6108 1730 0 None - 1 Human 7.2 pKi = 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23259957
6105 1714 0 None -14 2 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19053761
6107 1722 0 None 8 2 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19053761
6103 2407 0 None 18 3 Human 7.4 pKi = 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21333705
6074 2409 0 None 301 3 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23192661
6102 2406 0 None 3 3 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21333705
6110 1723 0 None -60 2 Human 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19199479
6116 1721 0 None -40 2 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19199479
6109 2790 0 None 17 2 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20121116
6075 2077 0 None 5 3 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23600864
6114 1717 0 None -7 2 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19199479
155817474 1698 0 None 5 5 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19467704
5357 1698 0 None 5 5 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19467704
6113 1716 0 None -11 2 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19199479
6115 1718 0 None -3 2 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19199479
6111 1719 0 None -20 2 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19199479
6112 1715 0 None -11 2 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19199479
155817463 765 0 None -58 8 Mouse 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
3861 765 0 None -58 8 Mouse 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
6095 1709 0 None 14 6 Rat 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
6095 1709 0 None 14 6 Rat 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
6106 1720 0 None -10 2 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23259957
3900 2418 0 None 31 3 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
3897 2412 0 None -13 6 Rat 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
16132180 1694 14 None -7 8 Mouse 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
16133822 1694 14 None -7 8 Mouse 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
6087 1694 14 None -7 8 Mouse 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
CHEMBL499980 1694 14 None -7 8 Mouse 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
155817465 1700 0 None -11 6 Rat 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
155817465 1700 0 None -11 6 Rat 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9405385
155817465 1700 0 None -11 6 Rat 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9742938
155817465 1700 0 None -11 6 Rat 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
3876 1700 0 None -11 6 Rat 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
3876 1700 0 None -11 6 Rat 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9405385
3876 1700 0 None -11 6 Rat 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9742938
3876 1700 0 None -11 6 Rat 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
155817464 1471 0 None -17 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
3866 1471 0 None -17 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
44587986 1471 0 None -17 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
91934870 1471 0 None -17 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
CHEMBL499179 1471 0 None -17 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
155817465 1700 0 None -7 6 Mouse 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
3876 1700 0 None -7 6 Mouse 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
6101 2405 0 None 75 3 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19467704
6141 1691 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
6099 2411 0 None -23 2 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11600206
6100 2416 0 None -25 3 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
6104 2408 0 None 45 3 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21333705
16132180 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
16132180 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
16132180 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9405385
16132180 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
16132180 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9742938
16132180 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
16133822 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
16133822 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
16133822 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9405385
16133822 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
16133822 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9742938
16133822 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
6087 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
6087 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
6087 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9405385
6087 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
6087 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9742938
6087 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
CHEMBL499980 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
CHEMBL499980 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
CHEMBL499980 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9405385
CHEMBL499980 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
CHEMBL499980 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9742938
CHEMBL499980 1694 14 None -3 8 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
155817479 1706 0 None -1 6 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6083 1706 0 None -1 6 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6076 2078 0 None 2 3 Human 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23600864
3898 2413 0 None -20 7 Mouse 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
6139 1696 0 None 1 2 Rat 8.3 pKi = 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9405385
16132180 1694 14 None -3 8 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19053761
16132180 1694 14 None -3 8 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
16132180 1694 14 None -3 8 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
16133822 1694 14 None -3 8 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19053761
16133822 1694 14 None -3 8 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
16133822 1694 14 None -3 8 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6087 1694 14 None -3 8 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19053761
6087 1694 14 None -3 8 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
6087 1694 14 None -3 8 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
CHEMBL499980 1694 14 None -3 8 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19053761
CHEMBL499980 1694 14 None -3 8 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
CHEMBL499980 1694 14 None -3 8 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
101927062 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11983932
101927062 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
155817445 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11983932
155817445 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
16133823 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11983932
16133823 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
3592 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11983932
3592 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
44584852 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11983932
44584852 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
6090 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11983932
6090 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
91898917 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11983932
91898917 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
CHEMBL506553 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11983932
CHEMBL506553 1685 21 None -8 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
3896 2410 0 None -38 7 Rat 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15944002
3896 2410 0 None -38 7 Rat 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
3896 2410 0 None -38 7 Rat 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
3896 2410 0 None -38 7 Rat 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9405385
3896 2410 0 None -38 7 Rat 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
3896 2410 0 None -38 7 Rat 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
16133243 1684 0 None -26 8 Mouse 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
3593 1684 0 None -26 8 Mouse 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
3899 2414 0 None -26 8 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15944002
3899 2414 0 None -26 8 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
3899 2414 0 None -26 8 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
3899 2414 0 None -26 8 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9405385
3899 2414 0 None -26 8 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
3899 2414 0 None -26 8 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
16131409 1693 0 None -4 3 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
6086 1693 0 None -4 3 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
155817463 765 0 None -13 8 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
155817463 765 0 None -13 8 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
155817463 765 0 None -13 8 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
155817463 765 0 None -13 8 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
3861 765 0 None -13 8 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
3861 765 0 None -13 8 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
3861 765 0 None -13 8 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
3861 765 0 None -13 8 Rat 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
155817487 1699 0 None 8 4 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6130 1699 0 None 8 4 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
3899 2414 0 None -21 8 Mouse 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
101927062 1685 21 None -8 6 Rat 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
155817445 1685 21 None -8 6 Rat 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
16133823 1685 21 None -8 6 Rat 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
3592 1685 21 None -8 6 Rat 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
44584852 1685 21 None -8 6 Rat 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
6090 1685 21 None -8 6 Rat 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
91898917 1685 21 None -8 6 Rat 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
CHEMBL506553 1685 21 None -8 6 Rat 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
155817479 1706 0 None 1 6 Rat 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
6083 1706 0 None 1 6 Rat 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
3899 2414 0 None -18 8 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
3899 2414 0 None -18 8 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
3898 2413 0 None -9 7 Rat 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15944002
3898 2413 0 None -9 7 Rat 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
3898 2413 0 None -9 7 Rat 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
3898 2413 0 None -9 7 Rat 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
3898 2413 0 None -9 7 Rat 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
16133243 1684 0 None -14 8 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19467704
16133243 1684 0 None -14 8 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21333705
16133243 1684 0 None -14 8 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
16133243 1684 0 None -14 8 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
3593 1684 0 None -14 8 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19467704
3593 1684 0 None -14 8 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21333705
3593 1684 0 None -14 8 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
3593 1684 0 None -14 8 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
3898 2413 0 None -7 7 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
3898 2413 0 None -7 7 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
16133243 1684 0 None -12 8 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15944002
16133243 1684 0 None -12 8 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
16133243 1684 0 None -12 8 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9405385
16133243 1684 0 None -12 8 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
16133243 1684 0 None -12 8 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9742938
16133243 1684 0 None -12 8 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
3593 1684 0 None -12 8 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15944002
3593 1684 0 None -12 8 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
3593 1684 0 None -12 8 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9405385
3593 1684 0 None -12 8 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
3593 1684 0 None -12 8 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9742938
3593 1684 0 None -12 8 Rat 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
3897 2412 0 None -8 6 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11600206
3897 2412 0 None -8 6 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
101927062 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11600206
101927062 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
101927062 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
155817445 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11600206
155817445 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
155817445 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
16133823 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11600206
16133823 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
16133823 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
3592 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11600206
3592 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
3592 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
44584852 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11600206
44584852 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
44584852 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6090 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11600206
6090 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
6090 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
91898917 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11600206
91898917 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
91898917 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
CHEMBL506553 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11600206
CHEMBL506553 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
CHEMBL506553 1685 21 None -8 6 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
3896 2410 0 None -13 7 Mouse 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
155817463 765 0 None -4 8 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
155817463 765 0 None -4 8 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
3861 765 0 None -4 8 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
3861 765 0 None -4 8 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
155817484 1686 0 None -1 6 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6117 1686 0 None -1 6 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
6129 1686 0 None -1 6 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9880084
155817465 1700 0 None 7 6 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
3876 1700 0 None 7 6 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
6137 1697 0 None - 1 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9480833
155817484 1686 0 None -3 6 Rat 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
155817484 1686 0 None -3 6 Rat 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
6117 1686 0 None -3 6 Rat 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
6117 1686 0 None -3 6 Rat 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
6129 1686 0 None -3 6 Rat 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
6129 1686 0 None -3 6 Rat 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
16131409 1693 0 None 4 3 Rat 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
6086 1693 0 None 4 3 Rat 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
3897 2412 0 None -13 6 Rat 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9305929
3897 2412 0 None -13 6 Rat 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9722565
6127 1731 0 None -575 3 Rat 5.0 pKi > 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 397 3 0 4 5.2 COc1ccc(cn1)N1C(=O)/C(=N/c2ccc(c(c2)Cl)Cl)/c2c1cccc2 15944002
9800980 1731 0 None -575 3 Rat 5.0 pKi > 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 397 3 0 4 5.2 COc1ccc(cn1)N1C(=O)/C(=N/c2ccc(c(c2)Cl)Cl)/c2c1cccc2 15944002
1471834 3572 36 None -588 3 Human 5.0 pKi > 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 366 2 0 2 5.5 O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1ccccc1)cccc2 16287967
6126 3572 36 None -588 3 Human 5.0 pKi > 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 366 2 0 2 5.5 O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1ccccc1)cccc2 16287967
CHEMBL210288 3572 36 None -588 3 Human 5.0 pKi > 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 366 2 0 2 5.5 O=C1C(=Nc2cccc(c2)C(F)(F)F)c2c(N1c1ccccc1)cccc2 16287967
155817481 1702 0 None -3 6 Mouse 5.7 pKi > 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
6092 1702 0 None -3 6 Mouse 5.7 pKi > 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
155817482 1688 0 None -2 3 Mouse 5.7 pKi > 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
6093 1688 0 None -2 3 Mouse 5.7 pKi > 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9832122
6133 1466 0 None -1 2 Rat 5.9 pKi > 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9281594
155817480 1701 0 None 1 6 Human 6.0 pKi > 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None <