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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

1-OH-PGE₁	36	None	0	Mouse	Binding	pKi	None	-	6.70	-	1	Unclassified	Guide to Pharmacology	370.2	13	4	5	2.45	CC(O)CCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/9313928
11-deoxy-PGE₁	7	None	0	Human	Binding	pKi	None	-	8.90	1	6	Unclassified	Guide to Pharmacology	338.2	13	2	3	4.50	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/10952683
11-deoxy-PGE₁	7	None	0	Mouse	Binding	pKi	None	-	7.60	-19	6	Unclassified	Guide to Pharmacology	338.2	13	2	3	4.50	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/9313928
11-deoxy-PGE₂	8	None	0	Rat	Binding	pKi	None	-	9.00	-	1	Unclassified	Guide to Pharmacology	336.2	12	2	3	4.28	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)[C@@H]1C/C=C\CCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/9537820
13,14-dihydro-PGE₁	17	None	0	Human	Binding	pKi	None	-	8.50	-	1	Unclassified	Guide to Pharmacology	356.3	14	3	4	3.70	CCCCC[C@H](O)CC[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/10952683
16,16-dimethyl-PGE₂	24	None	0	Mouse	Binding	pKi	None	-	7.40	-20	3	Unclassified	Guide to Pharmacology	380.3	12	3	4	3.89	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/9313928
19(R)-OH-PGE₂	28	None	0	Rat	Binding	pKi	None	-	7.50	5	3	Unclassified	Guide to Pharmacology	368.2	12	4	5	2.22	C[C@@H](O)CCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/9537820
2-(4'-Methylaminophenyl)Benzothiazole	220178	3H-EP2	0	Human	Binding	pKi	=	12.00	7.92	-6	7	-	PDSP KiDatabase	268.1	3	1	5	4.75	CNc1ccc(N=Nc2ccc3ncsc3c2)cc1	-
AH-23848	218901	3H-PGE2	0	Human	Binding	pKi	=	9287.00	5.03	-9	6	-	PDSP KiDatabase	477.3	11	1	5	5.08	O=C1CCC(CCC(=CCC(C(=O)O)N2CCOCC2)OCc2ccc(-c3ccccc3)cc2)C1	-
AH-23848	218901	3H-PGE2	0	Human	Binding	pKi	=	10000.00	5.00	-9	6	-	PDSP KiDatabase	477.3	11	1	5	5.08	O=C1CCC(CCC(=CCC(C(=O)O)N2CCOCC2)OCc2ccc(-c3ccccc3)cc2)C1	-
AH-23848	218901	3H-PGE2	0	Human	Binding	pKi	=	10000.00	5.00	-9	6	-	PDSP KiDatabase	477.3	11	1	5	5.08	O=C1CCC(CCC(=CCC(C(=O)O)N2CCOCC2)OCc2ccc(-c3ccccc3)cc2)C1	-
AH-23848	218901	3H-PGE2	0	Human	Binding	pKi	=	10000.00	5.00	-9	6	-	PDSP KiDatabase	477.3	11	1	5	5.08	O=C1CCC(CCC(=CCC(C(=O)O)N2CCOCC2)OCc2ccc(-c3ccccc3)cc2)C1	-
AH23848	318	None	0	Human	Binding	pKi	None	-	5.25	-12	3	Unclassified	Guide to Pharmacology	477.3	11	1	5	4.73	O=C(O)CC/C=C\CC[C@H]1[C@@H](OCc2ccc(-c3ccccc3)cc2)CC(=O)[C@@H]1N1CCOCC1	https://pubmed.ncbi.nlm.nih.gov/10634944
AH23848	318	None	0	Human	Binding	pKi	None	-	5.25	-12	3	Unclassified	Guide to Pharmacology	477.3	11	1	5	4.73	O=C(O)CC/C=C\CC[C@H]1[C@@H](OCc2ccc(-c3ccccc3)cc2)CC(=O)[C@@H]1N1CCOCC1	https://pubmed.ncbi.nlm.nih.gov/10952683
AH23848	318	None	0	Human	Binding	pKi	None	-	5.00	-12	3	Unclassified	Guide to Pharmacology	477.3	11	1	5	4.73	O=C(O)CC/C=C\CC[C@H]1[C@@H](OCc2ccc(-c3ccccc3)cc2)CC(=O)[C@@H]1N1CCOCC1	https://pubmed.ncbi.nlm.nih.gov/10634944
AH23848	318	None	0	Rat	Binding	pKi	None	-	5.10	-12	3	Unclassified	Guide to Pharmacology	477.3	11	1	5	4.73	O=C(O)CC/C=C\CC[C@H]1[C@@H](OCc2ccc(-c3ccccc3)cc2)CC(=O)[C@@H]1N1CCOCC1	https://pubmed.ncbi.nlm.nih.gov/9537820
AH23848 (racemic)	319	None	0	Rat	Binding	pKi	None	-	5.00	-	1	Unclassified	Guide to Pharmacology	477.3	11	1	5	4.73	O=C(O)CC/C=C/CCC1C(OCc2ccc(-c3ccccc3)cc2)CC(=O)C1N1CCOCC1	https://pubmed.ncbi.nlm.nih.gov/9537820
AH6809	320	3H-PGE2	49	Human	Binding	pKi	=	10000.00	5.00	-10	10	-	PDSP KiDatabase	298.1	3	1	4	3.43	CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1	-
AH6809	320	3H-PGE2	49	Human	Binding	pKi	=	1150.00	5.94	-10	10	-	PDSP KiDatabase	298.1	3	1	4	3.43	CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1	-
amisulpride	400	3H-PGE2	72	Human	Binding	pKi	=	10000.00	5.00	-4365	53	-	PDSP KiDatabase	369.2	7	2	6	1.28	CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)c(N)cc1OC	-

Showing 1 to 20 of 1,261 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

11-deoxy-PGE₁	7	None	0	Human	Functional	pEC50	=	-	9.33	-	6	Unclassified	Guide to Pharmacology	338.2	13	2	3	4.50	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/19584306
BAY1316957	578	None	26	Human	Functional	pIC50	=	-	7.82	-	1	Unclassified	Guide to Pharmacology	441.2	6	1	5	5.79	CCn1c2ccc(C)cc2c2cc(-c3nc4c(C)c(C(=O)O)ccc4n3CCOC)ccc21	https://pubmed.ncbi.nlm.nih.gov/30707023
BAY1316957	578	None	26	Human	Functional	IC50	=	15.30	7.82	-	1	Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay	ChEMBL	441.2	6	1	5	5.79	CCn1c2ccc(C)cc2c2cc(-c3nc4c(C)c(C(=O)O)ccc4n3CCOC)ccc21	https://dx.doi.org/10.1021/acs.jmedchem.8b01862
CHEMBL1083400	6660	None	0	Human	Functional	IC50	=	1.12	8.95	-	2	Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay	ChEMBL	500.1	6	2	3	6.55	C[C@H](NC(=O)c1cc(Cl)cc2ccn(Cc3ccc(C(F)(F)F)cc3)c12)c1ccc(C(=O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.04.065
CHEMBL1084009	6840	None	21	Human	Functional	IC50	=	9.50	8.02	-	7	Antagonist activity at prostanoid EP4 receptor in human whole blood assessed as inhibition of TNF-alpha-induced IP-10 release in presence EP4 agonist L-000902688	ChEMBL	478.1	6	2	3	5.83	O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.04.065
CHEMBL1084009	6840	None	21	Human	Functional	IC50	=	1.80	8.74	-	7	Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay in presence of 10% human serum	ChEMBL	478.1	6	2	3	5.83	O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.04.065
CHEMBL1084009	6840	None	21	Human	Functional	IC50	=	1.30	8.89	-	7	Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay	ChEMBL	478.1	6	2	3	5.83	O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.04.065
CHEMBL1084551	6959	None	0	Human	Functional	IC50	=	11.80	7.93	-	2	Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay	ChEMBL	466.1	6	2	3	5.90	C[C@H](NC(=O)c1cccc2ccn(Cc3cccc(C(F)(F)F)c3)c12)c1ccc(C(=O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.04.065
CHEMBL1084552	6960	None	0	Human	Functional	IC50	=	1.40	8.85	-	2	Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay	ChEMBL	516.1	7	2	4	6.43	C[C@H](NC(=O)c1cccc2ccn(Cc3cc(Cl)cc(OC(F)(F)F)c3)c12)c1ccc(C(=O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.04.065
CHEMBL1084553	6961	None	0	Human	Functional	IC50	=	2.70	8.57	-	2	Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay	ChEMBL	466.1	6	2	3	5.90	C[C@H](NC(=O)c1cccc2ccn(Cc3ccc(C(F)(F)F)cc3)c12)c1ccc(C(=O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.04.065
CHEMBL1085040	7087	None	0	Human	Functional	IC50	=	1.50	8.82	-	2	Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay	ChEMBL	466.1	6	2	3	6.19	C[C@H](NC(=O)c1cc(Cl)cc2ccn(Cc3cccc(Cl)c3)c12)c1ccc(C(=O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.04.065
CHEMBL1085041	7088	None	0	Human	Functional	IC50	=	3.30	8.48	-	2	Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay	ChEMBL	450.1	6	2	3	5.67	C[C@H](NC(=O)c1cc(F)cc2ccn(Cc3cccc(Cl)c3)c12)c1ccc(C(=O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.04.065
CHEMBL1085081	7091	None	0	Human	Functional	IC50	=	5.90	8.23	-	2	Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay	ChEMBL	432.1	6	2	3	5.53	C[C@H](NC(=O)c1cccc2ccn(Cc3cccc(Cl)c3)c12)c1ccc(C(=O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.04.065
CHEMBL1085081	7091	None	0	Human	Functional	IC50	=	6.00	8.22	-	2	Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay	ChEMBL	432.1	6	2	3	5.53	C[C@H](NC(=O)c1cccc2ccn(Cc3cccc(Cl)c3)c12)c1ccc(C(=O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.10.106
CHEMBL1086490	7397	None	0	Human	Functional	IC50	=	1.26	8.90	-	2	Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay	ChEMBL	512.1	6	2	3	6.48	O=C(O)c1ccc(C2(NC(=O)c3cc(Cl)cc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.04.065
CHEMBL14359	35261	None	0	Human	Functional	EC50	=	140.00	6.85	-	3	Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells	ChEMBL	359.2	11	2	3	3.17	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)Cc1ccccc1	https://dx.doi.org/10.1016/j.bmcl.2004.01.063
CHEMBL1644003	56889	None	0	Human	Functional	IC50	=	1.20	8.92	-	4	Antagonist activity at human EP4 receptor in HEK293 cells by cell-based functional assay	ChEMBL	549.2	7	2	5	5.43	Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(=O)N(C)C)sc4c(C)cc(C)cc34)cc2)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.11.118
CHEMBL1644016	56903	None	0	Human	Functional	IC50	=	2.40	8.62	-	1	Antagonist activity at human EP4 receptor in HEK293 cells by cell-based functional assay	ChEMBL	500.2	8	1	4	5.80	COc1ccccc1CC(=O)NCCc1ccc(-c2c(C(=O)N(C)C)sc3c(C)cc(C)cc23)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.11.118
CHEMBL1645133	57112	None	0	Human	Functional	EC50	=	0.82	9.09	-	1	Agonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as potentiation of PGE2-induced cAMP accumulation by scintillation proximity assay	ChEMBL	434.1	6	2	3	5.09	C[C@H](NC(=O)c1cccc2c1N(Cc1cccc(Cl)c1)CC2)c1ccc(C(=O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.10.106
CHEMBL1645134	57113	None	0	Human	Functional	IC50	=	1.10	8.96	-	1	Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay	ChEMBL	468.1	6	2	3	5.75	C[C@H](NC(=O)c1cccc2c1N(Cc1ccc(Cl)c(Cl)c1)CC2)c1ccc(C(=O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.10.106

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Ligand source activities (1 row/activity)