Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL222715 pe2r4_human Human No 10.7 EC50 = 0.0 Funct
Agonist activity at human EP4 receptor by cAMP assayAgonist activity at human EP4 receptor by cAMP assay
359 10 2 4 3.3 CCCCCC(C=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL222715 pe2r4_human Human No 10.7 EC50 = 0.0 Funct
Agonist activity at human EP4 receptor by cAMP assayAgonist activity at human EP4 receptor by cAMP assay
359 10 2 4 3.3 CCCCCC(C=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL272276 pe2r4_human Human No 10.5 EC50 = 0.0 Funct
Agonist activity at human EP4 receptor by cAMP assayAgonist activity at human EP4 receptor by cAMP assay
379 8 2 4 2.9 C1CC(=O)N(C1C=CC(CC2=CC=CC=C2)O)CCC3=CC=C(C=C3)C(=O)O
CHEMBL258332 pe2r4_human Human No 10.5 EC50 = 0.0 Funct
Agonist activity at human EP4 receptor by cAMP assayAgonist activity at human EP4 receptor by cAMP assay
414 8 2 4 3.5 C1CC(=O)N(C1C=CC(CC2=CC(=CC=C2)Cl)O)CCC3=CC=C(C=C3)C(=O)O
CHEMBL272276 pe2r4_human Human No 10.5 EC50 = 0.0 Funct
Agonist activity at human EP4 receptor by cAMP assayAgonist activity at human EP4 receptor by cAMP assay
379 8 2 4 2.9 C1CC(=O)N(C1C=CC(CC2=CC=CC=C2)O)CCC3=CC=C(C=C3)C(=O)O
CHEMBL258332 pe2r4_human Human No 10.5 EC50 = 0.0 Funct
Agonist activity at human EP4 receptor by cAMP assayAgonist activity at human EP4 receptor by cAMP assay
414 8 2 4 3.5 C1CC(=O)N(C1C=CC(CC2=CC(=CC=C2)Cl)O)CCC3=CC=C(C=C3)C(=O)O
CHEMBL251294 pe2r4_human Human No 10.4 EC50 = 0.0 Funct
Agonist activity at human EP4 receptor by cAMP assayAgonist activity at human EP4 receptor by cAMP assay
345 9 2 4 2.8 CCCCC(C=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL222677 pe2r4_human Human No 10.4 EC50 = 0.0 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
492 9 2 4 5.5 CC1=C(C=CC(=C1)Cl)C2=CC(=CC=C2)C(CCC3CCC(=O)N3CCC4=CC=C(C=C4)C(=O)O)O
CHEMBL251294 pe2r4_human Human No 10.4 EC50 = 0.0 Funct
Agonist activity at human EP4 receptor by cAMP assayAgonist activity at human EP4 receptor by cAMP assay
345 9 2 4 2.8 CCCCC(C=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL222677 pe2r4_human Human No 10.4 EC50 = 0.0 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
492 9 2 4 5.5 CC1=C(C=CC(=C1)Cl)C2=CC(=CC=C2)C(CCC3CCC(=O)N3CCC4=CC=C(C=C4)C(=O)O)O
CHEMBL64804 pe2r4_human Human Yes 10.3 EC50 = 0.1 Funct
SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.
352 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL251505 pe2r4_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulation
355 9 1 3 5.0 CCCCC(=CC=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)C
CHEMBL249953 pe2r4_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at human prostaglandin EP4 receptorAgonist activity at human prostaglandin EP4 receptor
461 9 2 5 1.3 C1CN(N(C1=O)CCC2=CC=C(C=C2)C(=O)O)CCC(CC3=CC(=CC=C3)Br)O
CHEMBL251505 pe2r4_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulation
355 9 1 3 5.0 CCCCC(=CC=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)C
CHEMBL249953 pe2r4_human Human No 10.0 EC50 = 0.1 Funct
Agonist activity at human prostaglandin EP4 receptorAgonist activity at human prostaglandin EP4 receptor
461 9 2 5 1.3 C1CN(N(C1=O)CCC2=CC=C(C=C2)C(=O)O)CCC(CC3=CC(=CC=C3)Br)O
CHEMBL249538 pe2r4_human Human No 9.7 EC50 = 0.2 Funct
Agonist activity at human prostaglandin EP4 receptorAgonist activity at human prostaglandin EP4 receptor
461 9 2 5 1.3 C1CN(N(C1=O)CCC2=CC=C(C=C2)C(=O)O)CCC(CC3=CC(=CC=C3)Br)O
CHEMBL249744 pe2r4_human Human No 9.7 EC50 = 0.2 Funct
Agonist activity at human prostaglandin EP4 receptorAgonist activity at human prostaglandin EP4 receptor
417 9 2 5 1.2 C1CN(N(C1=O)CCC2=CC=C(C=C2)C(=O)O)CCC(CC3=CC(=CC=C3)Cl)O
CHEMBL1645138 pe2r4_human Human No 9.7 EC50 = 0.2 Funct
Agonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as potentiation of PGE2-induced cAMP accumulation by scintillation proximity assayAgonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as potentiation of PGE2-induced cAMP accumulation by scintillation proximity assay
468 6 2 7 5.2 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC(=CC=C4)C(F)(F)F
CHEMBL222782 pe2r4_human Human No 9.7 EC50 = 0.2 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
371 9 2 4 3.3 C1CC(C1)CCC(C=CC2CCC(=O)N2CCC3=CC=C(C=C3)C(=O)O)O
CHEMBL249538 pe2r4_human Human No 9.7 EC50 = 0.2 Funct
Agonist activity at human prostaglandin EP4 receptorAgonist activity at human prostaglandin EP4 receptor
461 9 2 5 1.3 C1CN(N(C1=O)CCC2=CC=C(C=C2)C(=O)O)CCC(CC3=CC(=CC=C3)Br)O
CHEMBL249744 pe2r4_human Human No 9.7 EC50 = 0.2 Funct
Agonist activity at human prostaglandin EP4 receptorAgonist activity at human prostaglandin EP4 receptor
417 9 2 5 1.2 C1CN(N(C1=O)CCC2=CC=C(C=C2)C(=O)O)CCC(CC3=CC(=CC=C3)Cl)O
CHEMBL1645138 pe2r4_human Human No 9.7 EC50 = 0.2 Funct
Agonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as potentiation of PGE2-induced cAMP accumulation by scintillation proximity assayAgonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as potentiation of PGE2-induced cAMP accumulation by scintillation proximity assay
468 6 2 7 5.2 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC(=CC=C4)C(F)(F)F
CHEMBL222782 pe2r4_human Human No 9.7 EC50 = 0.2 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
371 9 2 4 3.3 C1CC(C1)CCC(C=CC2CCC(=O)N2CCC3=CC=C(C=C3)C(=O)O)O
CHEMBL272277 pe2r4_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human EP4 receptor by cAMP assayAgonist activity at human EP4 receptor by cAMP assay
400 10 2 4 4.1 CCCCC1(CCC1)C(C=CC2CCC(=O)N2CCC3=CC=C(C=C3)C(=O)O)O
CHEMBL272277 pe2r4_human Human No 9.5 EC50 = 0.3 Funct
Agonist activity at human EP4 receptor by cAMP assayAgonist activity at human EP4 receptor by cAMP assay
400 10 2 4 4.1 CCCCC1(CCC1)C(C=CC2CCC(=O)N2CCC3=CC=C(C=C3)C(=O)O)O
CHEMBL1645142 pe2r4_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as potentiation of PGE2-induced cAMP accumulation by scintillation proximity assayAgonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as potentiation of PGE2-induced cAMP accumulation by scintillation proximity assay
558 6 2 4 5.7 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC(=CC(=C4)Br)Br
CHEMBL1645142 pe2r4_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as potentiation of PGE2-induced cAMP accumulation by scintillation proximity assayAgonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as potentiation of PGE2-induced cAMP accumulation by scintillation proximity assay
558 6 2 4 5.7 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC(=CC(=C4)Br)Br
CHEMBL64804 pe2r4_human Human Yes 9.3 EC50 = 0.5 Funct
cAMP Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 uL of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing 500 uM IBMX (an inhibitor of cAMP phosphodiesterase) and different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. Incubate the cells in a cell culture incubator for 30 minutes. 5. Centrifuge the plate at 1,000x rpm for 10 minutes. 6. Aspirate the supernatant.cAMP Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 uL of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing 500 uM IBMX (an inhibitor of cAMP phosphodiesterase) and different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. Incubate the cells in a cell culture incubator for 30 minutes. 5. Centrifuge the plate at 1,000x rpm for 10 minutes. 6. Aspirate the supernatant.
352 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL378376 pe2r4_rat Rat Yes 9.3 EC50 = 0.5 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
470 10 2 8 4.7 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL248679 pe2r4_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulation
375 7 1 3 4.7 CC(=CC=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)C3=CC=CC=C3
CHEMBL1933725 pe2r4_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
419 9 2 7 2.9 C1CC(=O)N(C1C=CC(CC2=CC=CC=C2)O)CCSC3=NC(=CS3)C(=O)O
CHEMBL378376 pe2r4_rat Rat Yes 9.3 EC50 = 0.5 Funct
Agonist activity at rat EP4 receptor expressed in HEK293 cells assessed as cAMP activationAgonist activity at rat EP4 receptor expressed in HEK293 cells assessed as cAMP activation
470 10 2 8 4.7 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL378376 pe2r4_rat Rat Yes 9.3 EC50 = 0.5 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
470 10 2 8 4.7 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL248679 pe2r4_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulation
375 7 1 3 4.7 CC(=CC=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)C3=CC=CC=C3
CHEMBL1933725 pe2r4_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
419 9 2 7 2.9 C1CC(=O)N(C1C=CC(CC2=CC=CC=C2)O)CCSC3=NC(=CS3)C(=O)O
CHEMBL378376 pe2r4_rat Rat Yes 9.3 EC50 = 0.5 Funct
Agonist activity at rat EP4 receptor expressed in HEK293 cells assessed as cAMP activationAgonist activity at rat EP4 receptor expressed in HEK293 cells assessed as cAMP activation
470 10 2 8 4.7 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL379746 pe2r4_rat Rat No 9.2 EC50 = 0.6 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
436 10 2 5 4.4 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)Cl)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL379746 pe2r4_rat Rat No 9.2 EC50 = 0.6 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
436 10 2 5 4.4 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)Cl)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL2036316 pe2r4_rat Rat No 9.2 EC50 = 0.6 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
485 14 2 7 2.4 C1CC(=O)N(C1C=CC(CC2=CC(=CC=C2)OCC3=CC=CC=N3)O)CCSCCCC(=O)O
CHEMBL2036316 pe2r4_rat Rat No 9.2 EC50 = 0.6 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
485 14 2 7 2.4 C1CC(=O)N(C1C=CC(CC2=CC(=CC=C2)OCC3=CC=CC=N3)O)CCSCCCC(=O)O
CHEMBL548 pe2r4_rat Rat Yes 9.2 EC50 = 0.7 Funct
Agonist activity against rat EP4 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP4 receptor expressed in HEK293 cells assessed as stimulation of cAMP release
353 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL548 pe2r4_rat Rat Yes 9.2 EC50 = 0.7 Funct
Agonist activity against rat EP4 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP4 receptor expressed in HEK293 cells assessed as stimulation of cAMP release
353 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL1933722 pe2r4_rat Rat No 9.1 EC50 = 0.8 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
433 9 2 7 3.2 CC1=CC(=CC=C1)CC(C=CC2CCC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL1933722 pe2r4_rat Rat No 9.1 EC50 = 0.8 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
433 9 2 7 3.2 CC1=CC(=CC=C1)CC(C=CC2CCC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL1933722 pe2r4_rat Rat No 9.1 EC50 = 0.8 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
433 9 2 7 3.2 CC1=CC(=CC=C1)CC(C=CC2CCC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL1933722 pe2r4_rat Rat No 9.1 EC50 = 0.8 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
433 9 2 7 3.2 CC1=CC(=CC=C1)CC(C=CC2CCC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL298026 pe2r4_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
470 11 2 4 4.9 CC1=C(C=CC(=C1)Cl)C2=CC(=CC=C2)C(C=CC3CCC(=O)N3CCCCCCC(=O)O)O
CHEMBL1645133 pe2r4_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as potentiation of PGE2-induced cAMP accumulation by scintillation proximity assayAgonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as potentiation of PGE2-induced cAMP accumulation by scintillation proximity assay
435 6 2 4 4.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC(=CC=C4)Cl
CHEMBL1645133 pe2r4_human Human No 9.1 EC50 = 0.8 Funct
Agonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as potentiation of PGE2-induced cAMP accumulation by scintillation proximity assayAgonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as potentiation of PGE2-induced cAMP accumulation by scintillation proximity assay
435 6 2 4 4.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC(=CC=C4)Cl
CHEMBL1929528 pe2r4_rat Rat No 9.0 EC50 = 1.1 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
421 13 2 6 2.5 COCC1=CC=CC(=C1)CC(C=CC2CCC(=O)C2CCSCCCC(=O)O)O
CHEMBL1929528 pe2r4_rat Rat No 9.0 EC50 = 1.1 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
421 13 2 6 2.5 COCC1=CC=CC(=C1)CC(C=CC2CCC(=O)C2CCSCCCC(=O)O)O
CHEMBL1929527 pe2r4_rat Rat No 8.9 EC50 = 1.3 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
422 13 2 6 1.6 COCC1=CC=CC(=C1)CC(C=CC2CCC(=O)N2CCSCCCC(=O)O)O
CHEMBL1929527 pe2r4_rat Rat No 8.9 EC50 = 1.3 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
422 13 2 6 1.6 COCC1=CC=CC(=C1)CC(C=CC2CCC(=O)N2CCSCCCC(=O)O)O
CHEMBL292964 pe2r4_rat Rat Yes 8.9 EC50 = 1.4 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
437 13 3 7 1.5 COCC1=CC=CC(=C1)CC(C=CC2C(CC(=O)C2CCSCCCC(=O)O)O)O
CHEMBL292964 pe2r4_rat Rat Yes 8.9 EC50 = 1.4 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
437 13 3 7 1.5 COCC1=CC=CC(=C1)CC(C=CC2C(CC(=O)C2CCSCCCC(=O)O)O)O
CHEMBL303960 pe2r4_mouse Mouse Yes 8.8 EC50 = 1.6 Funct
Agonist activity at mouse EP4 receptor expressed in CHO cells assessed as cAMP productionAgonist activity at mouse EP4 receptor expressed in CHO cells assessed as cAMP production
451 14 2 7 1.8 COCC1=CC=CC(=C1)CC(C=CC2C(CC(=O)C2CCSCCCC(=O)OC)O)O
CHEMBL2037289 pe2r4_rat Rat No 8.8 EC50 = 1.6 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
550 10 2 9 4.7 CC1=CC2=C(C=C1)N=C(O2)C3=CC(=CC=C3)CC(C=CC4CCC(=O)N4CCSC5=NC(=CS5)C(=O)O)O
CHEMBL303960 pe2r4_mouse Mouse Yes 8.8 EC50 = 1.6 Funct
Agonist activity at mouse EP4 receptor expressed in CHO cells assessed as cAMP productionAgonist activity at mouse EP4 receptor expressed in CHO cells assessed as cAMP production
451 14 2 7 1.8 COCC1=CC=CC(=C1)CC(C=CC2C(CC(=O)C2CCSCCCC(=O)OC)O)O
CHEMBL2037289 pe2r4_rat Rat No 8.8 EC50 = 1.6 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
550 10 2 9 4.7 CC1=CC2=C(C=C1)N=C(O2)C3=CC(=CC=C3)CC(C=CC4CCC(=O)N4CCSC5=NC(=CS5)C(=O)O)O
CHEMBL292964 pe2r4_mouse Mouse Yes 8.8 EC50 = 1.6 Funct
Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorEffective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor
437 13 3 7 1.5 COCC1=CC=CC(=C1)CC(C=CC2C(CC(=O)C2CCSCCCC(=O)O)O)O
CHEMBL382029 pe2r4_rat Rat No 8.8 EC50 = 1.7 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
402 10 2 5 3.8 C1CC(=O)N(C1CCC(CC2=CC=CC=C2)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL382029 pe2r4_rat Rat No 8.8 EC50 = 1.7 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
402 10 2 5 3.8 C1CC(=O)N(C1CCC(CC2=CC=CC=C2)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL1929540 pe2r4_rat Rat No 8.7 EC50 = 1.9 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
424 12 2 6 3.4 CCC1=CC(=CC=C1)CC(C=CC2CSC(=O)N2CCSCCCC(=O)O)O
CHEMBL1929540 pe2r4_rat Rat No 8.7 EC50 = 1.9 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
424 12 2 6 3.4 CCC1=CC(=CC=C1)CC(C=CC2CSC(=O)N2CCSCCCC(=O)O)O
CHEMBL1929548 pe2r4_rat Rat No 8.0 EC50 = 10 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
444 11 2 7 4.0 C1CC(=S)N(C1C=CC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCCCCC(=O)O
CHEMBL1929548 pe2r4_rat Rat No 8.0 EC50 = 10 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
444 11 2 7 4.0 C1CC(=S)N(C1C=CC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCCCCC(=O)O
CHEMBL292717 pe2r4_mouse Mouse No 8.0 EC50 = 10 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
483 15 3 8 2.9 CCCOCC1=CC=CC(=C1)CC(C=CC2C(CC(=O)C2SCCCSCC(=O)O)O)O
CHEMBL62868 pe2r4_mouse Mouse No 6.0 EC50 = 1000 Funct
Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorEffective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor
373 13 3 6 2.2 CCCCCC(C=CC1C(CC(=O)C1CCCSCCC(=O)O)O)O
CHEMBL60555 pe2r4_mouse Mouse No 6.0 EC50 = 1000 Funct
Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorEffective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor
373 13 3 6 2.2 CCCCCC(C=CC1C(CC(=O)C1CSCCCCC(=O)O)O)O
CHEMBL380839 pe2r4_rat Rat No 7.0 EC50 = 105 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
463 10 2 7 4.6 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCC3=CC=C(C=C3)C(=O)O
CHEMBL380839 pe2r4_rat Rat No 7.0 EC50 = 105 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
463 10 2 7 4.6 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCC3=CC=C(C=C3)C(=O)O
CHEMBL376063 pe2r4_human Human No 5.0 EC50 = 10700 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
329 11 2 5 2.1 CCCCCC(C=CC1CCC(=O)N1CCSCC(=O)O)O
CHEMBL376063 pe2r4_human Human No 5.0 EC50 = 10700 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
329 11 2 5 2.1 CCCCCC(C=CC1CCC(=O)N1CCSCC(=O)O)O
CHEMBL222715 pe2r4_human Human No 8.0 EC50 = 11 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
359 10 2 4 3.3 CCCCCC(C=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL222715 pe2r4_human Human No 8.0 EC50 = 11 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
359 10 2 4 3.3 CCCCCC(C=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL372926 pe2r4_human Human No 7.0 EC50 = 110 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
468 12 3 5 4.5 CC1=C(C=CC(=C1)O)C2=CC(=CC=C2)C(CCC3CCCC(=O)N3CCCCCCC(=O)O)O
CHEMBL372926 pe2r4_human Human No 7.0 EC50 = 110 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
468 12 3 5 4.5 CC1=C(C=CC(=C1)O)C2=CC(=CC=C2)C(CCC3CCCC(=O)N3CCCCCCC(=O)O)O
CHEMBL1929533 pe2r4_rat Rat No 7.9 EC50 = 12 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
447 11 2 9 2.9 C1C(N(C(=O)O1)CCSCCCC(=O)O)C=CC(CC2=CC(=CC=C2)C(F)(F)F)O
CHEMBL224970 pe2r4_human Human No 7.9 EC50 = 12 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
365 10 2 5 3.3 CCCCCC(C=CC1CCC(=O)N1CCC2=CC=C(S2)C(=O)O)O
CHEMBL45008 pe2r4_human Human No 7.9 EC50 = 12 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
427 11 2 7 3.4 C1CC(=O)N(C1C=CC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCCCCC(=O)O
CHEMBL1929533 pe2r4_rat Rat No 7.9 EC50 = 12 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
447 11 2 9 2.9 C1C(N(C(=O)O1)CCSCCCC(=O)O)C=CC(CC2=CC(=CC=C2)C(F)(F)F)O
CHEMBL62779 pe2r4_mouse Mouse No 7.9 EC50 = 12 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
469 14 3 8 2.4 COCCC1=CC(=CC=C1)CC(C=CC2C(CC(=O)C2SCCCSCC(=O)O)O)O
CHEMBL224970 pe2r4_human Human No 7.9 EC50 = 12 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
365 10 2 5 3.3 CCCCCC(C=CC1CCC(=O)N1CCC2=CC=C(S2)C(=O)O)O
CHEMBL42129 pe2r4_human Human No 6.9 EC50 = 120 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
366 11 2 4 3.7 C1CCC(CC1)CC(C=CC2CCC(=O)N2CCCCCCC(=O)O)O
CHEMBL3752406 pe2r4_human Human No 5.9 EC50 = 1220 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
447 12 2 9 3.6 CC(C)(CCCCF)C(C=CC1COC(=O)N1CCSC2=NC(=CS2)C(=O)O)O
CHEMBL3752406 pe2r4_human Human No 5.9 EC50 = 1220 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
447 12 2 9 3.6 CC(C)(CCCCF)C(C=CC1COC(=O)N1CCSC2=NC(=CS2)C(=O)O)O
CHEMBL46395 pe2r4_rat Rat No 7.9 EC50 = 13 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
429 12 2 7 3.9 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCCCCC(=O)O
CHEMBL2036312 pe2r4_rat Rat No 7.9 EC50 = 13 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
495 12 2 7 3.4 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=NC4=CC=CC=C4O3)O)CCSCCCC(=O)O
CHEMBL2036324 pe2r4_rat Rat No 7.9 EC50 = 13 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
552 10 2 9 5.0 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=NC4=CC=CC=C4S3)O)CCSC5=NC(=CS5)C(=O)O
CHEMBL46395 pe2r4_rat Rat No 7.9 EC50 = 13 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
429 12 2 7 3.9 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCCCCC(=O)O
CHEMBL444574 pe2r4_human Human No 7.9 EC50 = 13 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
452 11 3 5 3.9 CC1=C(C=CC(=C1)O)C2=CC(=CC=C2)C(C=CC3CCC(=O)N3CCCCCCC(=O)O)O
CHEMBL2036312 pe2r4_rat Rat No 7.9 EC50 = 13 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
495 12 2 7 3.4 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=NC4=CC=CC=C4O3)O)CCSCCCC(=O)O
CHEMBL2036324 pe2r4_rat Rat No 7.9 EC50 = 13 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
552 10 2 9 5.0 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=NC4=CC=CC=C4S3)O)CCSC5=NC(=CS5)C(=O)O
CHEMBL376347 pe2r4_human Human No 6.9 EC50 = 130 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
361 11 2 4 3.8 CCCCCC(CCC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL291182 pe2r4_human Human No 6.9 EC50 = 130 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
415 11 2 7 3.4 C1CC(=O)N(C1CCC(C2=CC(=CC=C2)C(F)(F)F)O)CCCCCCC(=O)O
CHEMBL376347 pe2r4_human Human No 6.9 EC50 = 130 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
361 11 2 4 3.8 CCCCCC(CCC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL439934 pe2r4_mouse Mouse No 7.9 EC50 = 14 Funct
Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorEffective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor
421 12 3 6 3.0 COCC1=CC=CC(=C1)CC(C=CC2C(CC(C2CC=CCCCC(=O)O)F)O)O
CHEMBL14359 pe2r4_human Human No 6.9 EC50 = 140 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
359 11 2 4 2.5 C1CC(=O)N(C1C=CC(CC2=CC=CC=C2)O)CCCCCCC(=O)O
CHEMBL251504 pe2r4_human Human No 7.8 EC50 = 15 Funct
Agonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulation
355 9 1 3 5.0 CCCCC(=CC=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)C
CHEMBL1929526 pe2r4_rat Rat No 7.8 EC50 = 15 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
404 13 2 5 2.2 COCC1=CC=CC(=C1)CC(C=CC2CCC(=O)N2CCCCCCC(=O)O)O
CHEMBL2036319 pe2r4_rat Rat No 7.8 EC50 = 15 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
525 11 2 8 4.5 COC1=CC=C(C=C1)C2=CC(=CC=C2)CC(C=CC3CCC(=O)N3CCSC4=NC(=CS4)C(=O)O)O
CHEMBL2036318 pe2r4_rat Rat No 7.8 EC50 = 15 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
509 10 2 7 4.9 CC1=CC=C(C=C1)C2=CC(=CC=C2)CC(C=CC3CCC(=O)N3CCSC4=NC(=CS4)C(=O)O)O
CHEMBL296715 pe2r4_human Human No 7.8 EC50 = 15 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
454 12 3 5 4.2 CC1=C(C=CC(=C1)O)C2=CC(=CC=C2)C(CCC3CCC(=O)N3CCCCCCC(=O)O)O
CHEMBL251504 pe2r4_human Human No 7.8 EC50 = 15 Funct
Agonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulation
355 9 1 3 5.0 CCCCC(=CC=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)C
CHEMBL1929526 pe2r4_rat Rat No 7.8 EC50 = 15 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
404 13 2 5 2.2 COCC1=CC=CC(=C1)CC(C=CC2CCC(=O)N2CCCCCCC(=O)O)O
CHEMBL2036319 pe2r4_rat Rat No 7.8 EC50 = 15 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
525 11 2 8 4.5 COC1=CC=C(C=C1)C2=CC(=CC=C2)CC(C=CC3CCC(=O)N3CCSC4=NC(=CS4)C(=O)O)O
CHEMBL2036318 pe2r4_rat Rat No 7.8 EC50 = 15 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
509 10 2 7 4.9 CC1=CC=C(C=C1)C2=CC(=CC=C2)CC(C=CC3CCC(=O)N3CCSC4=NC(=CS4)C(=O)O)O
CHEMBL223744 pe2r4_human Human No 6.8 EC50 = 150 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
373 10 2 4 3.8 C1CC(C1)CCC(CCC2CCC(=O)N2CCC3=CC=C(C=C3)C(=O)O)O
CHEMBL223744 pe2r4_human Human No 6.8 EC50 = 150 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
373 10 2 4 3.8 C1CC(C1)CCC(CCC2CCC(=O)N2CCC3=CC=C(C=C3)C(=O)O)O
CHEMBL1929537 pe2r4_rat Rat No 6.8 EC50 = 160 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
463 12 2 10 3.2 C1C(N(C(=O)O1)CCSCCCC(=O)O)C=CC(CC2=CC(=CC=C2)OC(F)(F)F)O
CHEMBL2036320 pe2r4_rat Rat No 6.8 EC50 = 160 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
523 10 2 7 5.2 CC1=CC(=C(C=C1)C2=CC(=CC=C2)CC(C=CC3CCC(=O)N3CCSC4=NC(=CS4)C(=O)O)O)C
CHEMBL1929537 pe2r4_rat Rat No 6.8 EC50 = 160 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
463 12 2 10 3.2 C1C(N(C(=O)O1)CCSCCCC(=O)O)C=CC(CC2=CC(=CC=C2)OC(F)(F)F)O
CHEMBL2036320 pe2r4_rat Rat No 6.8 EC50 = 160 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
523 10 2 7 5.2 CC1=CC(=C(C=C1)C2=CC(=CC=C2)CC(C=CC3CCC(=O)N3CCSC4=NC(=CS4)C(=O)O)O)C
CHEMBL60894 pe2r4_mouse Mouse No 6.8 EC50 = 160 Funct
Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorEffective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor
439 13 3 5 4.0 COCC1=CC=CC(=C1)CC(C=CC2C(CC(C2CCCCCCC(=O)O)Cl)O)O
CHEMBL223151 pe2r4_human Human No 7.8 EC50 = 17 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
358 13 2 5 2.3 CCCCCC(C=CC1CCC(=O)N1CCSCCCC(=O)O)O
CHEMBL440474 pe2r4_human Human No 7.8 EC50 = 17 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
427 11 2 7 3.4 C1CC(=O)N(C1C=CC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCCCCC(=O)O
CHEMBL223151 pe2r4_human Human No 7.8 EC50 = 17 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
358 13 2 5 2.3 CCCCCC(C=CC1CCC(=O)N1CCSCCCC(=O)O)O
CHEMBL203076 pe2r4_rat Rat No 6.8 EC50 = 170 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
377 12 3 5 2.7 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)O)O)CCCCCCC(=O)O
CHEMBL203076 pe2r4_rat Rat No 6.8 EC50 = 170 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
377 12 3 5 2.7 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)O)O)CCCCCCC(=O)O
CHEMBL47138 pe2r4_human Human No 6.8 EC50 = 170 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
456 11 2 4 4.5 C1CC(=O)N(C1C=CC(C2=CC=CC(=C2)C3=CC(=CC=C3)Cl)O)CCCCCCC(=O)O
CHEMBL304887 pe2r4_mouse Mouse No 6.8 EC50 = 170 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
391 13 3 7 2.2 CCCCCC(C=CC1C(CC(=O)C1SCCSCCC(=O)O)O)O
CHEMBL191748 pe2r4_human Human No 5.8 EC50 = 1730 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
432 12 3 5 3.7 CC(C)C1=C(C=CC(=C1)CC(C=CC2CCCC(=O)N2CCCCCCC(=O)O)O)O
CHEMBL191748 pe2r4_human Human No 5.8 EC50 = 1730 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
432 12 3 5 3.7 CC(C)C1=C(C=CC(=C1)CC(C=CC2CCCC(=O)N2CCCCCCC(=O)O)O)O
CHEMBL205819 pe2r4_rat Rat No 7.8 EC50 = 18 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
406 14 2 5 2.7 COCC1=CC=CC(=C1)CC(CCC2CCC(=O)N2CCCCCCC(=O)O)O
CHEMBL1929531 pe2r4_rat Rat No 7.8 EC50 = 18 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
408 12 2 6 2.9 CCC1=CC(=CC=C1)CC(C=CC2COC(=O)N2CCSCCCC(=O)O)O
CHEMBL205819 pe2r4_rat Rat No 7.8 EC50 = 18 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
406 14 2 5 2.7 COCC1=CC=CC(=C1)CC(CCC2CCC(=O)N2CCCCCCC(=O)O)O
CHEMBL1929531 pe2r4_rat Rat No 7.8 EC50 = 18 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
408 12 2 6 2.9 CCC1=CC(=CC=C1)CC(C=CC2COC(=O)N2CCSCCCC(=O)O)O
CHEMBL373558 pe2r4_human Human No 6.8 EC50 = 180 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
429 11 2 8 2.5 C1CC(=O)N(C1C=CC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCCOCC(=O)O
CHEMBL280223 pe2r4_human Human No 6.8 EC50 = 180 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
386 11 2 4 2.8 C1CC(=O)N(C1C=CC(C2(CC2)C3=CC=CC=C3)O)CCCCCCC(=O)O
CHEMBL373558 pe2r4_human Human No 6.8 EC50 = 180 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
429 11 2 8 2.5 C1CC(=O)N(C1C=CC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCCOCC(=O)O
CHEMBL2036315 pe2r4_rat Rat No 7.7 EC50 = 19 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
485 14 2 7 2.3 C1CC(=O)N(C1C=CC(CC2=CC(=CC=C2)OCC3=CN=CC=C3)O)CCSCCCC(=O)O
CHEMBL2036315 pe2r4_rat Rat No 7.7 EC50 = 19 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
485 14 2 7 2.3 C1CC(=O)N(C1C=CC(CC2=CC(=CC=C2)OCC3=CN=CC=C3)O)CCSCCCC(=O)O
CHEMBL191627 pe2r4_human Human No 6.7 EC50 = 190 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
370 12 2 5 2.2 C1CC(N(C(=O)C1)CCSCCCC(=O)O)C=CC(CCC2CC2)O
CHEMBL191627 pe2r4_human Human No 6.7 EC50 = 190 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
370 12 2 5 2.2 C1CC(N(C(=O)C1)CCSCCCC(=O)O)C=CC(CCC2CC2)O
CHEMBL3805176 pe2r4_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
416 7 2 7 3.6 C1CC(OC2C1C(C(C2)O)C=CCCOC3=CC=CC=C3)C4=NC(=CS4)C(=O)O
CHEMBL3805176 pe2r4_human Human No 5.7 EC50 = 1900 Funct
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
416 7 2 7 3.6 C1CC(OC2C1C(C(C2)O)C=CCCOC3=CC=CC=C3)C4=NC(=CS4)C(=O)O
CHEMBL208399 pe2r4_rat Rat No 6.7 EC50 = 195 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
438 13 2 4 4.6 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCCCCCC(=O)O
CHEMBL3751951 pe2r4_human Human No 6.7 EC50 = 195 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
459 12 2 9 3.6 C1CC(C1)(CCCCF)C(C=CC2COC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL208399 pe2r4_rat Rat No 6.7 EC50 = 195 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
438 13 2 4 4.6 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCCCCCC(=O)O
CHEMBL3751951 pe2r4_human Human No 6.7 EC50 = 195 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
459 12 2 9 3.6 C1CC(C1)(CCCCF)C(C=CC2COC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL251709 pe2r4_human Human No 8.7 EC50 = 2 Funct
Agonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulation
341 9 1 3 4.3 CCCCC=CC=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O
CHEMBL223151 pe2r4_rat Rat No 8.7 EC50 = 2 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
358 13 2 5 2.3 CCCCCC(C=CC1CCC(=O)N1CCSCCCC(=O)O)O
CHEMBL251709 pe2r4_human Human No 8.7 EC50 = 2 Funct
Agonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulation
341 9 1 3 4.3 CCCCC=CC=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O
CHEMBL223151 pe2r4_rat Rat No 8.7 EC50 = 2 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
358 13 2 5 2.3 CCCCCC(C=CC1CCC(=O)N1CCSCCCC(=O)O)O
CHEMBL2036323 pe2r4_rat Rat No 8.7 EC50 = 2.2 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
536 10 2 9 4.4 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=NC4=CC=CC=C4O3)O)CCSC5=NC(=CS5)C(=O)O
CHEMBL2036323 pe2r4_rat Rat No 8.7 EC50 = 2.2 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
536 10 2 9 4.4 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=NC4=CC=CC=C4O3)O)CCSC5=NC(=CS5)C(=O)O
CHEMBL378968 pe2r4_rat Rat No 8.6 EC50 = 2.4 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
420 10 2 6 3.9 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)F)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL1929544 pe2r4_rat Rat No 8.6 EC50 = 2.4 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
440 13 2 7 2.2 COCC1=CC=CC(=C1)CC(C=CC2CSC(=O)N2CCSCCCC(=O)O)O
CHEMBL378968 pe2r4_rat Rat No 8.6 EC50 = 2.4 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
420 10 2 6 3.9 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)F)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL1929544 pe2r4_rat Rat No 8.6 EC50 = 2.4 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
440 13 2 7 2.2 COCC1=CC=CC(=C1)CC(C=CC2CSC(=O)N2CCSCCCC(=O)O)O
CHEMBL275667 pe2r4_human Human Yes 8.6 EC50 = 2.5 Funct
EP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptorEP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptor
383 11 2 5 2.6 C1CC(=O)N(C1C=CC(CC2=CC=CC=C2)O)CCCCCCC3=NNN=N3
CHEMBL495 pe2r4_mouse Mouse Yes 8.6 EC50 = 2.5 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
355 13 3 5 3.2 CCCCCC(C=CC1C(CC(=O)C1CCCCCCC(=O)O)O)O
CHEMBL64557 pe2r4_mouse Mouse No 8.6 EC50 = 2.5 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
469 14 3 8 2.3 CCOCC1=CC=CC(=C1)CC(C=CC2C(CC(=O)C2SCCCSCC(=O)O)O)O
CHEMBL1928220 pe2r4_rabit Rabbit No 8.6 EC50 = 2.6 Funct
Agonist activity at rabbit EP4 receptor assessed as relaxation of Kcl-induced tissue contraction by isometric transducer methodAgonist activity at rabbit EP4 receptor assessed as relaxation of Kcl-induced tissue contraction by isometric transducer method
425 7 3 6 4.1 C1CCC(CC1)CC(C=CC2C(CC3C2C4=C(O3)C(=CC=C4)CCC5=NNN=N5)O)O
CHEMBL1928220 pe2r4_rabit Rabbit No 8.6 EC50 = 2.6 Funct
Agonist activity at rabbit EP4 receptor assessed as relaxation of Kcl-induced tissue contraction by isometric transducer methodAgonist activity at rabbit EP4 receptor assessed as relaxation of Kcl-induced tissue contraction by isometric transducer method
425 7 3 6 4.1 C1CCC(CC1)CC(C=CC2C(CC3C2C4=C(O3)C(=CC=C4)CCC5=NNN=N5)O)O
CHEMBL305568 pe2r4_mouse Mouse No 8.6 EC50 = 2.8 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
425 11 3 7 2.7 CC1=CC(=CC=C1)CC(C=CC2C(CC(=O)C2SCCCSCC(=O)O)O)O
CHEMBL293647 pe2r4_mouse Mouse No 7.7 EC50 = 20 Funct
Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorEffective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor
423 11 4 7 1.8 CC1=C(C=CC(=C1)CC(C=CC2C(CC(=O)C2CCSCCCC(=O)O)O)O)O
CHEMBL416262 pe2r4_human Human No 6.7 EC50 = 200 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
337 11 2 4 2.6 C1CC(C1)CC(C=CC2CCC(=O)N2CCCCCCC(=O)O)O
CHEMBL382197 pe2r4_rat Rat No 6.7 EC50 = 203 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
478 11 2 5 5.4 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCCC4=CC=C(S4)C(=O)O
CHEMBL382197 pe2r4_rat Rat No 6.7 EC50 = 203 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
478 11 2 5 5.4 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCCC4=CC=C(S4)C(=O)O
CHEMBL398948 pe2r4_human Human No 7.7 EC50 = 21 Funct
Agonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulation
355 9 1 3 5.0 CCCCC=C(C)C=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O
CHEMBL2036321 pe2r4_rat Rat No 7.7 EC50 = 21 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
523 10 2 7 5.2 CC1=C(C=C(C=C1)C2=CC(=CC=C2)CC(C=CC3CCC(=O)N3CCSC4=NC(=CS4)C(=O)O)O)C
CHEMBL398948 pe2r4_human Human No 7.7 EC50 = 21 Funct
Agonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulation
355 9 1 3 5.0 CCCCC=C(C)C=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O
CHEMBL2036321 pe2r4_rat Rat No 7.7 EC50 = 21 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
523 10 2 7 5.2 CC1=C(C=C(C=C1)C2=CC(=CC=C2)CC(C=CC3CCC(=O)N3CCSC4=NC(=CS4)C(=O)O)O)C
CHEMBL222085 pe2r4_human Human No 5.7 EC50 = 2100 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
341 13 2 5 2.0 CCCCCC(C=CC1CCC(=O)N1CCCCOCC(=O)O)O
CHEMBL222085 pe2r4_human Human No 5.7 EC50 = 2100 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
341 13 2 5 2.0 CCCCCC(C=CC1CCC(=O)N1CCCCOCC(=O)O)O
CHEMBL191874 pe2r4_human Human No 4.7 EC50 = 21000 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
466 12 2 5 4.6 CC1=C(C=CC(=C1)O)C2=CC(=CC=C2)C(=O)CCC3CCCC(=O)N3CCCCCCC(=O)O
CHEMBL191874 pe2r4_human Human No 4.7 EC50 = 21000 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
466 12 2 5 4.6 CC1=C(C=CC(=C1)O)C2=CC(=CC=C2)C(=O)CCC3CCCC(=O)N3CCCCCCC(=O)O
CHEMBL207237 pe2r4_rat Rat No 7.7 EC50 = 22 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
420 10 2 6 3.9 C1CC(=O)N(C1CCC(CC2=CC=C(C=C2)F)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL207237 pe2r4_rat Rat No 7.7 EC50 = 22 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
420 10 2 6 3.9 C1CC(=O)N(C1CCC(CC2=CC=C(C=C2)F)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL1929535 pe2r4_rat Rat No 7.6 EC50 = 23 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
414 11 2 6 2.7 C1C(N(C(=O)O1)CCSCCCC(=O)O)C=CC(CC2=CC(=CC=C2)Cl)O
CHEMBL1929535 pe2r4_rat Rat No 7.6 EC50 = 23 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
414 11 2 6 2.7 C1C(N(C(=O)O1)CCSCCCC(=O)O)C=CC(CC2=CC(=CC=C2)Cl)O
CHEMBL1929538 pe2r4_rat Rat No 7.6 EC50 = 24 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
424 13 2 7 1.7 COCC1=CC=CC(=C1)CC(C=CC2COC(=O)N2CCSCCCC(=O)O)O
CHEMBL1929538 pe2r4_rat Rat No 7.6 EC50 = 24 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
424 13 2 7 1.7 COCC1=CC=CC(=C1)CC(C=CC2COC(=O)N2CCSCCCC(=O)O)O
CHEMBL3753268 pe2r4_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
437 9 2 8 3.3 CC#CCC1(CCC1)C(C=CC2COC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL3753268 pe2r4_human Human No 6.6 EC50 = 240 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
437 9 2 8 3.3 CC#CCC1(CCC1)C(C=CC2COC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL1929549 pe2r4_rat Rat No 7.6 EC50 = 26 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
394 11 2 5 3.2 C1CC(=S)N(C1C=CC(CC2=CC(=CC=C2)F)O)CCCCCCC(=O)O
CHEMBL1929549 pe2r4_rat Rat No 7.6 EC50 = 26 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
394 11 2 5 3.2 C1CC(=S)N(C1C=CC(CC2=CC(=CC=C2)F)O)CCCCCCC(=O)O
CHEMBL192655 pe2r4_human Human No 6.6 EC50 = 260 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
418 11 2 5 2.6 C1CC(N(C(=O)C1)CCSCCCC(=O)O)C=CC(C2(CC2)C3=CC=CC=C3)O
CHEMBL192655 pe2r4_human Human No 6.6 EC50 = 260 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
418 11 2 5 2.6 C1CC(N(C(=O)C1)CCSCCCC(=O)O)C=CC(C2(CC2)C3=CC=CC=C3)O
CHEMBL1957436 pe2r4_rat Rat No 7.6 EC50 = 27 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
529 10 2 7 5.1 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC=C(C=C3)Cl)O)CCSC4=NC(=CS4)C(=O)O
CHEMBL1929547 pe2r4_rat Rat No 7.6 EC50 = 27 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
418 13 2 4 4.5 CCCC1=CC(=CC=C1)CC(C=CC2CCC(=S)N2CCCCCCC(=O)O)O
CHEMBL1957436 pe2r4_rat Rat No 7.6 EC50 = 27 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
529 10 2 7 5.1 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC=C(C=C3)Cl)O)CCSC4=NC(=CS4)C(=O)O
CHEMBL1957436 pe2r4_rat Rat No 7.6 EC50 = 27 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
529 10 2 7 5.1 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC=C(C=C3)Cl)O)CCSC4=NC(=CS4)C(=O)O
CHEMBL1929547 pe2r4_rat Rat No 7.6 EC50 = 27 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
418 13 2 4 4.5 CCCC1=CC(=CC=C1)CC(C=CC2CCC(=S)N2CCCCCCC(=O)O)O
CHEMBL1957436 pe2r4_rat Rat No 7.6 EC50 = 27 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
529 10 2 7 5.1 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC=C(C=C3)Cl)O)CCSC4=NC(=CS4)C(=O)O
CHEMBL64072 pe2r4_mouse Mouse No 6.6 EC50 = 270 Funct
Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorEffective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor
441 13 3 7 2.8 COCC1=CC=CC(=C1)CC(C=CC2C(CC(C2CCSCCCC(=O)O)F)O)O
CHEMBL59921 pe2r4_mouse Mouse No 6.6 EC50 = 270 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
425 11 3 7 2.7 CC1=CC=C(C=C1)CC(C=CC2C(CC(=O)C2SCCCSCC(=O)O)O)O
CHEMBL425950 pe2r4_rat Rat No 6.6 EC50 = 275 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
430 11 2 5 4.6 CCC1=CC=C(C=C1)CC(CCC2CCC(=O)N2CCCC3=CC=C(S3)C(=O)O)O
CHEMBL425950 pe2r4_rat Rat No 6.6 EC50 = 275 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
430 11 2 5 4.6 CCC1=CC=C(C=C1)CC(CCC2CCC(=O)N2CCCC3=CC=C(S3)C(=O)O)O
CHEMBL404413 pe2r4_human Human No 6.6 EC50 = 277 Funct
Agonist activity at human prostaglandin EP4 receptorAgonist activity at human prostaglandin EP4 receptor
348 9 2 5 0.3 CC(C)CC(CCN1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL404413 pe2r4_human Human No 6.6 EC50 = 277 Funct
Agonist activity at human prostaglandin EP4 receptorAgonist activity at human prostaglandin EP4 receptor
348 9 2 5 0.3 CC(C)CC(CCN1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL2037290 pe2r4_rat Rat No 7.6 EC50 = 28 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
550 10 2 9 4.7 CC1=C2C(=CC=C1)OC(=N2)C3=CC(=CC=C3)CC(C=CC4CCC(=O)N4CCSC5=NC(=CS5)C(=O)O)O
CHEMBL2036310 pe2r4_rat Rat No 7.6 EC50 = 28 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
495 12 2 6 3.1 C1CC(=O)N(C1C=CC(CC2=CC(=CC=C2)N3CC4=CC=CC=C4C3)O)CCSCCCC(=O)O
CHEMBL2037290 pe2r4_rat Rat No 7.6 EC50 = 28 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
550 10 2 9 4.7 CC1=C2C(=CC=C1)OC(=N2)C3=CC(=CC=C3)CC(C=CC4CCC(=O)N4CCSC5=NC(=CS5)C(=O)O)O
CHEMBL2036310 pe2r4_rat Rat No 7.6 EC50 = 28 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
495 12 2 6 3.1 C1CC(=O)N(C1C=CC(CC2=CC(=CC=C2)N3CC4=CC=CC=C4C3)O)CCSCCCC(=O)O
CHEMBL193405 pe2r4_human Human No 6.6 EC50 = 280 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
404 11 3 5 2.9 CC1=C(C=CC(=C1)CC(C=CC2CCCC(=O)N2CCCCCCC(=O)O)O)O
CHEMBL193405 pe2r4_human Human No 6.6 EC50 = 280 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
404 11 3 5 2.9 CC1=C(C=CC(=C1)CC(C=CC2CCCC(=O)N2CCCCCCC(=O)O)O)O
CHEMBL1929545 pe2r4_rat Rat No 7.5 EC50 = 29 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
376 11 2 4 3.1 C1CC(=S)N(C1C=CC(CC2=CC=CC=C2)O)CCCCCCC(=O)O
CHEMBL1929545 pe2r4_rat Rat No 7.5 EC50 = 29 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
376 11 2 4 3.1 C1CC(=S)N(C1C=CC(CC2=CC=CC=C2)O)CCCCCCC(=O)O
CHEMBL191790 pe2r4_human Human No 6.5 EC50 = 290 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
400 13 2 5 3.5 CCCCC(C)(C)C(C=CC1CCCC(=O)N1CCSCCCC(=O)O)O
CHEMBL191790 pe2r4_human Human No 6.5 EC50 = 290 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
400 13 2 5 3.5 CCCCC(C)(C)C(C=CC1CCCC(=O)N1CCSCCCC(=O)O)O
CHEMBL251710 pe2r4_human Human No 8.5 EC50 = 3 Funct
Agonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulation
327 7 1 3 3.9 CCC(=CC=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)C
CHEMBL3754586 pe2r4_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
427 12 2 7 4.2 CCCCC(C)CC(C=CC1CCC(=O)N1CCSC2=NC(=CS2)C(=O)O)O
CHEMBL548 pe2r4_human Human Yes 8.5 EC50 = 3 Funct
Agonist activity at human EP4 receptor by cAMP assayAgonist activity at human EP4 receptor by cAMP assay
353 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL257658 pe2r4_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human EP4 receptor by cAMP assayAgonist activity at human EP4 receptor by cAMP assay
388 10 2 4 4.1 CCCCC(C)(C)C(C=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL251710 pe2r4_human Human No 8.5 EC50 = 3 Funct
Agonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulation
327 7 1 3 3.9 CCC(=CC=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)C
CHEMBL3754586 pe2r4_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
427 12 2 7 4.2 CCCCC(C)CC(C=CC1CCC(=O)N1CCSC2=NC(=CS2)C(=O)O)O
CHEMBL548 pe2r4_human Human Yes 8.5 EC50 = 3 Funct
Agonist activity at human EP4 receptor by cAMP assayAgonist activity at human EP4 receptor by cAMP assay
353 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL257658 pe2r4_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human EP4 receptor by cAMP assayAgonist activity at human EP4 receptor by cAMP assay
388 10 2 4 4.1 CCCCC(C)(C)C(C=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL548 pe2r4_human Human Yes 8.5 EC50 = 3 Funct
EP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptorEP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptor
353 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL222715 pe2r4_rat Rat No 8.5 EC50 = 3.1 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
359 10 2 4 3.3 CCCCCC(C=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL222715 pe2r4_rat Rat No 8.5 EC50 = 3.1 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
359 10 2 4 3.3 CCCCCC(C=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL293856 pe2r4_mouse Mouse Yes 8.5 EC50 = 3.1 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
455 13 3 8 2.0 COCC1=CC=CC(=C1)CC(C=CC2C(CC(=O)C2SCCCSCC(=O)O)O)O
CHEMBL2036313 pe2r4_rat Rat No 8.5 EC50 = 3.2 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
511 12 2 7 4.1 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=NC4=CC=CC=C4S3)O)CCSCCCC(=O)O
CHEMBL2036313 pe2r4_rat Rat No 8.5 EC50 = 3.2 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
511 12 2 7 4.1 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=NC4=CC=CC=C4S3)O)CCSCCCC(=O)O
CHEMBL291630 pe2r4_mouse Mouse No 8.5 EC50 = 3.3 Funct
Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorEffective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor
437 12 3 5 3.3 COCC1=CC=CC(=C1)CC(C=CC2C(CC(C2CC=CCCCC(=O)O)Cl)O)O
CHEMBL548 pe2r4_rat Rat Yes 8.5 EC50 = 3.5 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
353 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL548 pe2r4_rat Rat Yes 8.5 EC50 = 3.5 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
353 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL495 pe2r4_mouse Mouse Yes 8.4 EC50 = 3.6 Funct
Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorEffective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor
355 13 3 5 3.2 CCCCCC(C=CC1C(CC(=O)C1CCCCCCC(=O)O)O)O
CHEMBL64187 pe2r4_mouse Mouse No 8.4 EC50 = 3.6 Funct
Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorEffective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor
373 13 3 6 2.2 CCCCCC(C=CC1C(CC(=O)C1CCSCCCC(=O)O)O)O
CHEMBL294108 pe2r4_mouse Mouse No 8.4 EC50 = 3.7 Funct
Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorEffective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor
373 13 3 6 2.7 CCCCCC(C=CC1C(CC(=O)C1SCCCCCC(=O)O)O)O
CHEMBL294108 pe2r4_mouse Mouse No 8.4 EC50 = 3.7 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
373 13 3 6 2.7 CCCCCC(C=CC1C(CC(=O)C1SCCCCCC(=O)O)O)O
CHEMBL305126 pe2r4_mouse Mouse No 7.5 EC50 = 32 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
441 12 3 8 2.3 COC1=CC=C(C=C1)CC(C=CC2C(CC(=O)C2SCCCSCC(=O)O)O)O
CHEMBL203780 pe2r4_rat Rat No 7.5 EC50 = 32.5 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
361 12 2 4 3.0 C1CC(=O)N(C1CCC(CC2=CC=CC=C2)O)CCCCCCC(=O)O
CHEMBL203780 pe2r4_rat Rat No 7.5 EC50 = 32.5 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
361 12 2 4 3.0 C1CC(=O)N(C1CCC(CC2=CC=CC=C2)O)CCCCCCC(=O)O
CHEMBL3753853 pe2r4_human Human No 6.5 EC50 = 320 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
429 11 2 8 4.2 CCCCC(C)(C)C(C=CC1COC(=O)N1CCSC2=NC(=CS2)C(=O)O)O
CHEMBL3753853 pe2r4_human Human No 6.5 EC50 = 320 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
429 11 2 8 4.2 CCCCC(C)(C)C(C=CC1COC(=O)N1CCSC2=NC(=CS2)C(=O)O)O
CHEMBL3804978 pe2r4_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
432 7 3 8 2.4 C1CC(OC2C1C(C(C2)O)C=CC(COC3=CC=CC=C3)O)C4=NC(=CS4)C(=O)O
CHEMBL1929530 pe2r4_rat Rat No 7.5 EC50 = 33 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
393 11 2 6 2.4 CC1=CC(=CC=C1)CC(C=CC2COC(=O)N2CCSCCCC(=O)O)O
CHEMBL3804978 pe2r4_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
432 7 3 8 2.4 C1CC(OC2C1C(C(C2)O)C=CC(COC3=CC=CC=C3)O)C4=NC(=CS4)C(=O)O
CHEMBL1929530 pe2r4_rat Rat No 7.5 EC50 = 33 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
393 11 2 6 2.4 CC1=CC(=CC=C1)CC(C=CC2COC(=O)N2CCSCCCC(=O)O)O
CHEMBL3751951 pe2r4_human Human No 6.5 EC50 = 339 Funct
Agonist activity at recombinant human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA
459 12 2 9 3.6 C1CC(C1)(CCCCF)C(C=CC2COC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL372894 pe2r4_human Human No 7.5 EC50 = 34 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
384 12 2 5 2.7 C1CC(C1)CCC(C=CC2CCCC(=O)N2CCSCCCC(=O)O)O
CHEMBL372894 pe2r4_human Human No 7.5 EC50 = 34 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
384 12 2 5 2.7 C1CC(C1)CCC(C=CC2CCCC(=O)N2CCSCCCC(=O)O)O
CHEMBL64542 pe2r4_mouse Mouse No 7.5 EC50 = 34 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
411 11 3 7 2.3 C1C(C(C(C1=O)SCCCSCC(=O)O)C=CC(CC2=CC=CC=C2)O)O
CHEMBL1929534 pe2r4_rat Rat No 7.5 EC50 = 35 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
397 11 2 7 2.2 C1C(N(C(=O)O1)CCSCCCC(=O)O)C=CC(CC2=CC(=CC=C2)F)O
CHEMBL1929534 pe2r4_rat Rat No 7.5 EC50 = 35 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
397 11 2 7 2.2 C1C(N(C(=O)O1)CCSCCCC(=O)O)C=CC(CC2=CC(=CC=C2)F)O
CHEMBL1929529 pe2r4_rat Rat No 7.4 EC50 = 36 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
379 11 2 6 2.1 C1C(N(C(=O)O1)CCSCCCC(=O)O)C=CC(CC2=CC=CC=C2)O
CHEMBL1929529 pe2r4_rat Rat No 7.4 EC50 = 36 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
379 11 2 6 2.1 C1C(N(C(=O)O1)CCSCCCC(=O)O)C=CC(CC2=CC=CC=C2)O
CHEMBL47018 pe2r4_human Human No 6.4 EC50 = 360 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
422 11 2 4 3.9 C1CC(=O)N(C1C=CC(C2=CC=CC(=C2)C3=CC=CC=C3)O)CCCCCCC(=O)O
CHEMBL62888 pe2r4_mouse Mouse No 7.4 EC50 = 37 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
441 12 3 8 2.3 COC1=CC=CC(=C1)CC(C=CC2C(CC(=O)C2SCCCSCC(=O)O)O)O
CHEMBL398947 pe2r4_human Human No 8.4 EC50 = 4 Funct
Agonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulation
313 6 1 3 3.4 CC(=CC=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)C
CHEMBL398947 pe2r4_human Human No 8.4 EC50 = 4 Funct
Agonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP4 receptor expressed in HEK293 cells assessed as cAMP accumulation
313 6 1 3 3.4 CC(=CC=CC1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)C
CHEMBL3752377 pe2r4_human Human No 8.4 EC50 = 4.2 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
427 11 2 7 4.1 CCCCC(C)(C)C(C=CC1CCC(=O)N1CCSC2=NC(=CS2)C(=O)O)O
CHEMBL3752377 pe2r4_human Human No 8.4 EC50 = 4.2 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
427 11 2 7 4.1 CCCCC(C)(C)C(C=CC1CCC(=O)N1CCSC2=NC(=CS2)C(=O)O)O
CHEMBL1929542 pe2r4_rat Rat No 8.4 EC50 = 4.3 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
464 11 2 9 3.5 C1C(N(C(=O)S1)CCSCCCC(=O)O)C=CC(CC2=CC(=CC=C2)C(F)(F)F)O
CHEMBL1929542 pe2r4_rat Rat No 8.4 EC50 = 4.3 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
464 11 2 9 3.5 C1C(N(C(=O)S1)CCSCCCC(=O)O)C=CC(CC2=CC(=CC=C2)C(F)(F)F)O
CHEMBL64217 pe2r4_mouse Mouse No 8.4 EC50 = 4.3 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
391 13 3 7 2.7 CCCCCC(C=CC1C(CC(=O)C1SCCCSCC(=O)O)O)O
CHEMBL1929539 pe2r4_rat Rat No 8.3 EC50 = 4.8 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
396 11 2 6 2.6 C1C(N(C(=O)S1)CCSCCCC(=O)O)C=CC(CC2=CC=CC=C2)O
CHEMBL1929539 pe2r4_rat Rat No 8.3 EC50 = 4.8 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
396 11 2 6 2.6 C1C(N(C(=O)S1)CCSCCCC(=O)O)C=CC(CC2=CC=CC=C2)O
CHEMBL64338 pe2r4_mouse Mouse No 8.3 EC50 = 4.8 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
471 13 3 8 2.8 CSCC1=CC=CC(=C1)CC(C=CC2C(CC(=O)C2SCCCSCC(=O)O)O)O
CHEMBL2037292 pe2r4_rat Rat No 8.3 EC50 = 4.9 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
570 10 2 9 5.0 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=NC4=C(O3)C=CC(=C4)Cl)O)CCSC5=NC(=CS5)C(=O)O
CHEMBL2037292 pe2r4_rat Rat No 8.3 EC50 = 4.9 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
570 10 2 9 5.0 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=NC4=C(O3)C=CC(=C4)Cl)O)CCSC5=NC(=CS5)C(=O)O
CHEMBL425243 pe2r4_rat Rat No 7.4 EC50 = 40 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
436 10 2 5 4.4 C1CC(=O)N(C1CCC(CC2=CC=C(C=C2)Cl)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL425243 pe2r4_rat Rat No 7.4 EC50 = 40 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
436 10 2 5 4.4 C1CC(=O)N(C1CCC(CC2=CC=C(C=C2)Cl)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL297578 pe2r4_human Human No 7.4 EC50 = 40 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
456 11 2 4 4.5 C1CC(=O)N(C1C=CC(C2=CC=CC(=C2)C3=CC=CC=C3Cl)O)CCCCCCC(=O)O
CHEMBL45418 pe2r4_human Human No 7.4 EC50 = 40 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
403 10 2 8 2.3 C1CC(=O)N(C1C=CC(C2=CC=C(O2)C(F)(F)F)O)CCCCCCC(=O)O
CHEMBL303787 pe2r4_mouse Mouse No 6.4 EC50 = 420 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
425 11 3 7 2.7 CC1=CC=CC=C1CC(C=CC2C(CC(=O)C2SCCCSCC(=O)O)O)O
CHEMBL416254 pe2r4_human Human No 4.4 EC50 = 42000 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
422 11 2 4 3.9 C1CC(=O)N(C1C=CC(C2=CC=CC=C2C3=CC=CC=C3)O)CCCCCCC(=O)O
CHEMBL383515 pe2r4_rat Rat No 6.4 EC50 = 425 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
430 10 2 4 4.4 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)Cl)O)CCCC3=CC=C(C=C3)C(=O)O
CHEMBL383515 pe2r4_rat Rat No 6.4 EC50 = 425 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
430 10 2 4 4.4 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)Cl)O)CCCC3=CC=C(C=C3)C(=O)O
CHEMBL372436 pe2r4_human Human No 7.4 EC50 = 44 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
436 13 2 6 2.0 COCC1=CC=CC(=C1)CC(C=CC2CCCC(=O)N2CCSCCCC(=O)O)O
CHEMBL413563 pe2r4_human Human No 7.4 EC50 = 44 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
418 13 2 5 2.6 COCC1=CC=CC(=C1)CC(C=CC2CCCC(=O)N2CCCCCCC(=O)O)O
CHEMBL63061 pe2r4_mouse Mouse No 7.4 EC50 = 44 Funct
Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorEffective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor
423 10 4 5 3.6 CC1=C(C=CC(=C1)CC(C=CC2C(CC(C2CC=CCCCC(=O)O)Cl)O)O)O
CHEMBL372436 pe2r4_human Human No 7.4 EC50 = 44 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
436 13 2 6 2.0 COCC1=CC=CC(=C1)CC(C=CC2CCCC(=O)N2CCSCCCC(=O)O)O
CHEMBL413563 pe2r4_human Human No 7.4 EC50 = 44 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
418 13 2 5 2.6 COCC1=CC=CC(=C1)CC(C=CC2CCCC(=O)N2CCCCCCC(=O)O)O
CHEMBL303532 pe2r4_mouse Mouse No 7.4 EC50 = 44 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
483 15 3 8 2.8 COCCCC1=CC(=CC=C1)CC(C=CC2C(CC(=O)C2SCCCSCC(=O)O)O)O
CHEMBL208411 pe2r4_rat Rat No 6.4 EC50 = 440 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
472 11 2 4 5.4 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCCC4=CC=C(C=C4)C(=O)O
CHEMBL208411 pe2r4_rat Rat No 6.4 EC50 = 440 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
472 11 2 4 5.4 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCCC4=CC=C(C=C4)C(=O)O
CHEMBL1929536 pe2r4_rat Rat No 6.4 EC50 = 450 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
456 12 2 6 3.7 C1C(N(C(=O)O1)CCSCCCC(=O)O)C=CC(CC2=CC=CC(=C2)C3=CC=CC=C3)O
CHEMBL1929536 pe2r4_rat Rat No 6.4 EC50 = 450 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
456 12 2 6 3.7 C1C(N(C(=O)O1)CCSCCCC(=O)O)C=CC(CC2=CC=CC(=C2)C3=CC=CC=C3)O
CHEMBL2036317 pe2r4_rat Rat No 7.3 EC50 = 46 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
485 14 2 7 2.3 C1CC(=O)N(C1C=CC(CC2=CC(=CC=C2)OCC3=CC=NC=C3)O)CCSCCCC(=O)O
CHEMBL2036317 pe2r4_rat Rat No 7.3 EC50 = 46 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
485 14 2 7 2.3 C1CC(=O)N(C1C=CC(CC2=CC(=CC=C2)OCC3=CC=NC=C3)O)CCSCCCC(=O)O
CHEMBL64188 pe2r4_mouse Mouse No 7.3 EC50 = 46 Funct
Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptorEffective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor
373 13 3 6 2.7 CCCCCC(C=CC1C(CC(=O)C1CCCCSCC(=O)O)O)O
CHEMBL46395 pe2r4_human Human No 6.3 EC50 = 460 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
429 12 2 7 3.9 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCCCCC(=O)O
CHEMBL3805134 pe2r4_human Human No 5.3 EC50 = 4600 Funct
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
390 9 3 6 2.3 C1CC2C(CC(C2C=CC(COC3=CC=CC=C3)O)O)OC1CCCC(=O)O
CHEMBL3805134 pe2r4_human Human No 5.3 EC50 = 4600 Funct
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
390 9 3 6 2.3 C1CC2C(CC(C2C=CC(COC3=CC=CC=C3)O)O)OC1CCCC(=O)O
CHEMBL3753622 pe2r4_human Human No 6.3 EC50 = 465 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
489 11 2 8 4.5 C1CC(C1)(CCC2=CC=CC=C2)C(C=CC3COC(=O)N3CCSC4=NC(=CS4)C(=O)O)O
CHEMBL3753622 pe2r4_human Human No 6.3 EC50 = 465 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
489 11 2 8 4.5 C1CC(C1)(CCC2=CC=CC=C2)C(C=CC3COC(=O)N3CCSC4=NC(=CS4)C(=O)O)O
CHEMBL3752435 pe2r4_human Human No 5.3 EC50 = 4710 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
469 11 2 8 4.8 CC(C)(C)CCC1(CCC1)C(C=CC2COC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL3752435 pe2r4_human Human No 5.3 EC50 = 4710 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
469 11 2 8 4.8 CC(C)(C)CCC1(CCC1)C(C=CC2COC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL1957437 pe2r4_rat Rat No 6.3 EC50 = 480 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
545 10 2 7 5.7 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC4=CC=CC=C4C=C3)O)CCSC5=NC(=CS5)C(=O)O
CHEMBL1957437 pe2r4_rat Rat No 6.3 EC50 = 480 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
545 10 2 7 5.7 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC4=CC=CC=C4C=C3)O)CCSC5=NC(=CS5)C(=O)O
CHEMBL1957437 pe2r4_rat Rat No 6.3 EC50 = 480 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
545 10 2 7 5.7 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC4=CC=CC=C4C=C3)O)CCSC5=NC(=CS5)C(=O)O
CHEMBL1957437 pe2r4_rat Rat No 6.3 EC50 = 480 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
545 10 2 7 5.7 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC4=CC=CC=C4C=C3)O)CCSC5=NC(=CS5)C(=O)O
CHEMBL249136 pe2r4_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human prostaglandin EP4 receptorAgonist activity at human prostaglandin EP4 receptor
362 11 2 5 0.9 CCCCCC(CCN1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL249136 pe2r4_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human prostaglandin EP4 receptorAgonist activity at human prostaglandin EP4 receptor
362 11 2 5 0.9 CCCCCC(CCN1CCC(=O)N1CCC2=CC=C(C=C2)C(=O)O)O
CHEMBL2036322 pe2r4_rat Rat No 8.3 EC50 = 5.3 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
535 10 2 8 4.9 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC4=CC=CC=C4O3)O)CCSC5=NC(=CS5)C(=O)O
CHEMBL2036322 pe2r4_rat Rat No 8.3 EC50 = 5.3 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
535 10 2 8 4.9 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC4=CC=CC=C4O3)O)CCSC5=NC(=CS5)C(=O)O
CHEMBL1928221 pe2r4_rabit Rabbit No 8.2 EC50 = 5.7 Funct
Agonist activity at rabbit EP4 receptor assessed as relaxation of Kcl-induced tissue contraction by isometric transducer methodAgonist activity at rabbit EP4 receptor assessed as relaxation of Kcl-induced tissue contraction by isometric transducer method
401 7 3 5 4.1 C1CCC(CC1)CC(C=CC2C(CC3C2C4=C(O3)C(=CC=C4)CCC(=O)O)O)O
CHEMBL1929543 pe2r4_rat Rat No 8.2 EC50 = 5.7 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
414 11 2 7 2.7 C1C(N(C(=O)S1)CCSCCCC(=O)O)C=CC(CC2=CC(=CC=C2)F)O
CHEMBL1933717 pe2r4_rat Rat No 8.2 EC50 = 5.7 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
392 11 2 5 2.3 CC1=CC(=CC=C1)CC(C=CC2CCC(=O)N2CCSCCCC(=O)O)O
CHEMBL1928221 pe2r4_rabit Rabbit No 8.2 EC50 = 5.7 Funct
Agonist activity at rabbit EP4 receptor assessed as relaxation of Kcl-induced tissue contraction by isometric transducer methodAgonist activity at rabbit EP4 receptor assessed as relaxation of Kcl-induced tissue contraction by isometric transducer method
401 7 3 5 4.1 C1CCC(CC1)CC(C=CC2C(CC3C2C4=C(O3)C(=CC=C4)CCC(=O)O)O)O
CHEMBL1929543 pe2r4_rat Rat No 8.2 EC50 = 5.7 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
414 11 2 7 2.7 C1C(N(C(=O)S1)CCSCCCC(=O)O)C=CC(CC2=CC(=CC=C2)F)O
CHEMBL1933717 pe2r4_rat Rat No 8.2 EC50 = 5.7 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
392 11 2 5 2.3 CC1=CC(=CC=C1)CC(C=CC2CCC(=O)N2CCSCCCC(=O)O)O
CHEMBL222834 pe2r4_human Human No 8.2 EC50 = 5.9 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
424 10 2 5 2.6 COCC1=CC=CC(=C1)CC(C=CC2CCC(=O)N2CCC3=CC=C(C=C3)C(=O)O)O
CHEMBL222834 pe2r4_human Human No 8.2 EC50 = 5.9 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
424 10 2 5 2.6 COCC1=CC=CC(=C1)CC(C=CC2CCC(=O)N2CCC3=CC=C(C=C3)C(=O)O)O
CHEMBL208510 pe2r4_rat Rat No 7.3 EC50 = 50 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
445 13 2 8 4.2 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)OC(F)(F)F)O)CCCCCCC(=O)O
CHEMBL208510 pe2r4_rat Rat No 7.3 EC50 = 50 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
445 13 2 8 4.2 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)OC(F)(F)F)O)CCCCCCC(=O)O
CHEMBL46671 pe2r4_human Human No 7.3 EC50 = 50 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
456 11 2 4 4.5 C1CC(=O)N(C1C=CC(C2=CC=CC(=C2)C3=CC=C(C=C3)Cl)O)CCCCCCC(=O)O
CHEMBL208410 pe2r4_rat Rat No 6.3 EC50 = 500 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
452 10 2 5 5.0 C1CC(=O)N(C1CCC(CC2=CC3=CC=CC=C3C=C2)O)CCCC4=CC=C(S4)C(=O)O
CHEMBL208410 pe2r4_rat Rat No 6.3 EC50 = 500 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
452 10 2 5 5.0 C1CC(=O)N(C1CCC(CC2=CC3=CC=CC=C3C=C2)O)CCCC4=CC=C(S4)C(=O)O
CHEMBL417171 pe2r4_human Human No 6.3 EC50 = 500 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
413 10 2 7 3.1 C1CC(=O)N(C1C=CC(C2=CC(=CC=C2)C(F)(F)F)O)CCCCCCC(=O)O
CHEMBL2036307 pe2r4_rat Rat No 7.3 EC50 = 52 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
454 12 2 5 3.6 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCSCCCC(=O)O
CHEMBL2036307 pe2r4_rat Rat No 7.3 EC50 = 52 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
454 12 2 5 3.6 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCSCCCC(=O)O
CHEMBL42027 pe2r4_human Human Yes 7.3 EC50 = 56 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
339 13 2 4 2.9 CCCCCC(C=CC1CCC(=O)N1CCCCCCC(=O)O)O
CHEMBL42027 pe2r4_human Human Yes 7.3 EC50 = 56 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
339 13 2 4 2.9 CCCCCC(C=CC1CCC(=O)N1CCCCCCC(=O)O)O
CHEMBL42027 pe2r4_human Human Yes 7.3 EC50 = 56 Funct
Functional activity at human EP4 receptorFunctional activity at human EP4 receptor
339 13 2 4 2.9 CCCCCC(C=CC1CCC(=O)N1CCCCCCC(=O)O)O
CHEMBL62305 pe2r4_mouse Mouse No 6.2 EC50 = 580 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
441 12 3 8 2.3 COC1=CC=CC=C1CC(C=CC2C(CC(=O)C2SCCCSCC(=O)O)O)O
CHEMBL1929541 pe2r4_rat Rat No 8.2 EC50 = 6.1 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
438 13 2 6 3.9 CCCC1=CC(=CC=C1)CC(C=CC2CSC(=O)N2CCSCCCC(=O)O)O
CHEMBL192743 pe2r4_human Human No 8.2 EC50 = 6.1 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
504 12 2 5 4.9 CC1=C(C=CC(=C1)Cl)C2=CC(=CC=C2)C(CCC3CCCC(=O)N3CCSCCCC(=O)O)O
CHEMBL413509 pe2r4_human Human No 8.2 EC50 = 6.1 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
353 12 3 5 1.5 CCCCCC(C=CC1C(CC(=O)N1CC=CCCCC(=O)O)O)O
CHEMBL1929541 pe2r4_rat Rat No 8.2 EC50 = 6.1 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
438 13 2 6 3.9 CCCC1=CC(=CC=C1)CC(C=CC2CSC(=O)N2CCSCCCC(=O)O)O
CHEMBL192743 pe2r4_human Human No 8.2 EC50 = 6.1 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
504 12 2 5 4.9 CC1=C(C=CC(=C1)Cl)C2=CC(=CC=C2)C(CCC3CCCC(=O)N3CCSCCCC(=O)O)O
CHEMBL43766 pe2r4_human Human No 5.2 EC50 = 6100 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
339 13 2 4 2.9 CCCCCC(C=CC1CCC(=O)N1CCCCCCC(=O)O)O
CHEMBL191770 pe2r4_human Human No 6.2 EC50 = 630 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
437 11 2 9 2.3 C1CC(N(C(=O)C1)CCSCCCC(=O)O)CCC(C2=CC=C(O2)C(F)(F)F)O
CHEMBL191770 pe2r4_human Human No 6.2 EC50 = 630 Funct
Effective concentration required for prostanoid EP4 receptor activity was determinedEffective concentration required for prostanoid EP4 receptor activity was determined
437 11 2 9 2.3 C1CC(N(C(=O)C1)CCSCCCC(=O)O)CCC(C2=CC=C(O2)C(F)(F)F)O
CHEMBL2036314 pe2r4_rat Rat No 8.2 EC50 = 7 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
494 12 2 6 4.0 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC4=CC=CC=C4O3)O)CCSCCCC(=O)O
CHEMBL2036314 pe2r4_rat Rat No 8.2 EC50 = 7 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
494 12 2 6 4.0 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC4=CC=CC=C4O3)O)CCSCCCC(=O)O
CHEMBL1929550 pe2r4_rat Rat No 8.1 EC50 = 7.3 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
420 13 2 5 2.8 COCC1=CC=CC(=C1)CC(C=CC2CCC(=S)N2CCCCCCC(=O)O)O
CHEMBL1929550 pe2r4_rat Rat No 8.1 EC50 = 7.3 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
420 13 2 5 2.8 COCC1=CC=CC(=C1)CC(C=CC2CCC(=S)N2CCCCCCC(=O)O)O
CHEMBL548 pe2r4_human Human Yes 8.1 EC50 = 7.5 Funct
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
353 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL548 pe2r4_human Human Yes 8.1 EC50 = 7.5 Funct
Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
353 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL1929551 pe2r4_rat Rat No 8.1 EC50 = 7.7 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
408 11 2 5 2.9 CC1=CC(=CC=C1)CC(C=CC2CCC(=S)N2CCSCCCC(=O)O)O
CHEMBL2037291 pe2r4_rat Rat No 8.1 EC50 = 7.7 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
564 10 2 9 5.1 CC1=CC(=C2C(=C1)N=C(O2)C3=CC(=CC=C3)CC(C=CC4CCC(=O)N4CCSC5=NC(=CS5)C(=O)O)O)C
CHEMBL1929551 pe2r4_rat Rat No 8.1 EC50 = 7.7 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
408 11 2 5 2.9 CC1=CC(=CC=C1)CC(C=CC2CCC(=S)N2CCSCCCC(=O)O)O
CHEMBL2037291 pe2r4_rat Rat No 8.1 EC50 = 7.7 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
564 10 2 9 5.1 CC1=CC(=C2C(=C1)N=C(O2)C3=CC(=CC=C3)CC(C=CC4CCC(=O)N4CCSC5=NC(=CS5)C(=O)O)O)C
CHEMBL64254 pe2r4_mouse Mouse No 8.1 EC50 = 7.7 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
374 13 3 7 1.9 CCCCCC(C=CC1C(CC(=O)C1SCCCOCC(=O)O)O)O
CHEMBL3753788 pe2r4_human Human No 6.2 EC50 = 705 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
457 12 2 9 2.7 COCCCC1(CCC1)C(C=CC2COC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL3753788 pe2r4_human Human No 6.2 EC50 = 705 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
457 12 2 9 2.7 COCCCC1(CCC1)C(C=CC2COC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL3753221 pe2r4_human Human No 7.1 EC50 = 73 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
441 11 2 8 4.1 CCCCC1(CCC1)C(C=CC2COC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL3753221 pe2r4_human Human No 7.1 EC50 = 73 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
441 11 2 8 4.1 CCCCC1(CCC1)C(C=CC2COC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL3753898 pe2r4_human Human No 6.1 EC50 = 745 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
457 12 2 9 2.7 CCOCCC1(CCC1)C(C=CC2COC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL3753898 pe2r4_human Human No 6.1 EC50 = 745 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
457 12 2 9 2.7 CCOCCC1(CCC1)C(C=CC2COC(=O)N2CCSC3=NC(=CS3)C(=O)O)O
CHEMBL64598 pe2r4_mouse Mouse No 5.1 EC50 = 7800 Funct
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP4 receptor
391 13 3 7 2.2 CCCCCC(C=CC1C(CC(=O)C1CSCCSCC(=O)O)O)O
CHEMBL1957435 pe2r4_rat Rat No 8.1 EC50 = 8 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
495 10 2 7 4.5 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCSC4=NC(=CS4)C(=O)O
CHEMBL1957435 pe2r4_rat Rat No 8.1 EC50 = 8 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
495 10 2 7 4.5 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCSC4=NC(=CS4)C(=O)O
CHEMBL1957435 pe2r4_rat Rat No 8.1 EC50 = 8 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
495 10 2 7 4.5 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCSC4=NC(=CS4)C(=O)O
CHEMBL1957435 pe2r4_rat Rat No 8.1 EC50 = 8 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
495 10 2 7 4.5 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCSC4=NC(=CS4)C(=O)O
CHEMBL42027 pe2r4_rat Rat Yes 8.1 EC50 = 8.4 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
339 13 2 4 2.9 CCCCCC(C=CC1CCC(=O)N1CCCCCCC(=O)O)O
CHEMBL42027 pe2r4_rat Rat Yes 8.1 EC50 = 8.4 Funct
Agonist activity at rat EP4 receptorAgonist activity at rat EP4 receptor
339 13 2 4 2.9 CCCCCC(C=CC1CCC(=O)N1CCCCCCC(=O)O)O
CHEMBL204058 pe2r4_rat Rat No 8.1 EC50 = 8.8 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
396 12 2 4 3.6 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)Cl)O)CCCCCCC(=O)O
CHEMBL2036326 pe2r4_rat Rat No 8.1 EC50 = 8.8 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
550 10 2 9 4.7 CC1=CC2=C(C=C1)OC(=N2)C3=CC(=CC=C3)CC(C=CC4CCC(=O)N4CCSC5=NC(=CS5)C(=O)O)O
CHEMBL204058 pe2r4_rat Rat No 8.1 EC50 = 8.8 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
396 12 2 4 3.6 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)Cl)O)CCCCCCC(=O)O
CHEMBL2036326 pe2r4_rat Rat No 8.1 EC50 = 8.8 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
550 10 2 9 4.7 CC1=CC2=C(C=C1)OC(=N2)C3=CC(=CC=C3)CC(C=CC4CCC(=O)N4CCSC5=NC(=CS5)C(=O)O)O
CHEMBL3754197 pe2r4_human Human No 5.1 EC50 = 8390 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
495 11 2 8 5.8 C1CCC(CC1)CCC2(CCC2)C(C=CC3COC(=O)N3CCSC4=NC(=CS4)C(=O)O)O
CHEMBL3754197 pe2r4_human Human No 5.1 EC50 = 8390 Funct
Agonist activity at human EP4 receptorAgonist activity at human EP4 receptor
495 11 2 8 5.8 C1CCC(CC1)CCC2(CCC2)C(C=CC3COC(=O)N3CCSC4=NC(=CS4)C(=O)O)O
CHEMBL2036311 pe2r4_rat Rat No 7.1 EC50 = 85 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
493 12 3 5 3.7 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC4=C(C=C3)NC=C4)O)CCSCCCC(=O)O
CHEMBL288978 pe2r4_human Human No 7.1 EC50 = 85 Funct
Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsAgonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells
438 12 2 5 3.8 C1CC(=O)N(C1C=CC(C2=CC(=CC=C2)OC3=CC=CC=C3)O)CCCCCCC(=O)O
CHEMBL2036311 pe2r4_rat Rat No 7.1 EC50 = 85 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
493 12 3 5 3.7 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC4=C(C=C3)NC=C4)O)CCSCCCC(=O)O
CHEMBL2036309 pe2r4_rat Rat No 7.1 EC50 = 86 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
455 12 2 6 2.5 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC=CC=N3)O)CCSCCCC(=O)O
CHEMBL2036309 pe2r4_rat Rat No 7.1 EC50 = 86 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
455 12 2 6 2.5 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC=CC=N3)O)CCSCCCC(=O)O
CHEMBL1929546 pe2r4_rat Rat No 8.0 EC50 = 9.4 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
404 12 2 4 3.9 CCC1=CC(=CC=C1)CC(C=CC2CCC(=S)N2CCCCCCC(=O)O)O
CHEMBL1929546 pe2r4_rat Rat No 8.0 EC50 = 9.4 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
404 12 2 4 3.9 CCC1=CC(=CC=C1)CC(C=CC2CCC(=S)N2CCCCCCC(=O)O)O
CHEMBL2036325 pe2r4_rat Rat No 8.0 EC50 = 9.7 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
586 10 2 9 5.6 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=NC4=C(S3)C=CC(=C4)Cl)O)CCSC5=NC(=CS5)C(=O)O
CHEMBL2036325 pe2r4_rat Rat No 8.0 EC50 = 9.7 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
586 10 2 9 5.6 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=NC4=C(S3)C=CC(=C4)Cl)O)CCSC5=NC(=CS5)C(=O)O
CHEMBL383339 pe2r4_rat Rat No 7.0 EC50 = 92 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
420 15 2 5 3.1 COCCC1=CC(=CC=C1)CC(CCC2CCC(=O)N2CCCCCCC(=O)O)O
CHEMBL383339 pe2r4_rat Rat No 7.0 EC50 = 92 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
420 15 2 5 3.1 COCCC1=CC(=CC=C1)CC(CCC2CCC(=O)N2CCCCCCC(=O)O)O
CHEMBL1929532 pe2r4_rat Rat No 7.0 EC50 = 93 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
422 13 2 6 3.4 CCCC1=CC(=CC=C1)CC(C=CC2COC(=O)N2CCSCCCC(=O)O)O
CHEMBL1929532 pe2r4_rat Rat No 7.0 EC50 = 93 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
422 13 2 6 3.4 CCCC1=CC(=CC=C1)CC(C=CC2COC(=O)N2CCSCCCC(=O)O)O
CHEMBL425409 pe2r4_rat Rat No 7.0 EC50 = 96 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
386 12 2 5 2.7 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C#N)O)CCCCCCC(=O)O
CHEMBL2036308 pe2r4_rat Rat No 7.0 EC50 = 96 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
504 12 2 5 4.8 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC4=CC=CC=C4C=C3)O)CCSCCCC(=O)O
CHEMBL425409 pe2r4_rat Rat No 7.0 EC50 = 96 Funct
Activity at rat EP4 transfected in HEK293 cells by cAMP accumulationActivity at rat EP4 transfected in HEK293 cells by cAMP accumulation
386 12 2 5 2.7 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C#N)O)CCCCCCC(=O)O
CHEMBL2036308 pe2r4_rat Rat No 7.0 EC50 = 96 Funct
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay
504 12 2 5 4.8 C1CC(=O)N(C1C=CC(CC2=CC=CC(=C2)C3=CC4=CC=CC=C4C=C3)O)CCSCCCC(=O)O
CHEMBL3753860 pe2r4_human Human No 9.6 IC50 = 0.3 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
389 5 3 4 4.1 CC1=C(C=C(C=C1)C2=CC(=CC=C2)CO)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3753860 pe2r4_human Human No 9.6 IC50 = 0.3 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
389 5 3 4 4.1 CC1=C(C=C(C=C1)C2=CC(=CC=C2)CO)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL64804 pe2r4_human Human Yes 9.4 IC50 = 0.4 Funct
Radioligand Binding Assay: Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22° C. with 0.5 nM [3H]PGE2 in the absence or presence of the test compound in a buffer containing 10 mM MES/KOH (pH 6.0), 10 mM MgCl2 and 1 mM EDTA.Nonspecific binding is determined in the presence of 10 M PGE2.Following incubation, the samples are filtered rapidly under vacuum through glass fiber filters (GF/B, Packard) presoaked with 0.3% PEI and rinsed several times with ice-cold 50 mM Tris-HCl using a 96-sample cell harvester (Unifilter, Packard). The filters are dried then counted for radioactivity in a scintillation counter (Topcount, Packard) using a scintillation cocktail (Microscint 0, Packard).Radioligand Binding Assay: Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22° C. with 0.5 nM [3H]PGE2 in the absence or presence of the test compound in a buffer containing 10 mM MES/KOH (pH 6.0), 10 mM MgCl2 and 1 mM EDTA.Nonspecific binding is determined in the presence of 10 M PGE2.Following incubation, the samples are filtered rapidly under vacuum through glass fiber filters (GF/B, Packard) presoaked with 0.3% PEI and rinsed several times with ice-cold 50 mM Tris-HCl using a 96-sample cell harvester (Unifilter, Packard). The filters are dried then counted for radioactivity in a scintillation counter (Topcount, Packard) using a scintillation cocktail (Microscint 0, Packard).
352 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL548 pe2r4_human Human Yes 9.3 IC50 = 0.6 Funct
Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP4 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method
353 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL3753835 pe2r4_human Human No 9.2 IC50 = 0.7 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
390 5 3 5 3.4 CC1=C(N=C(C=C1)C2=CC(=CC=C2)CO)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3752948 pe2r4_human Human No 9.2 IC50 = 0.7 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
444 5 3 8 3.9 CC1=CC(=CC(=C1NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C(F)(F)F)C)C(=O)O
CHEMBL3753835 pe2r4_human Human No 9.2 IC50 = 0.7 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
390 5 3 5 3.4 CC1=C(N=C(C=C1)C2=CC(=CC=C2)CO)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3752948 pe2r4_human Human No 9.2 IC50 = 0.7 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
444 5 3 8 3.9 CC1=CC(=CC(=C1NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C(F)(F)F)C)C(=O)O
CHEMBL548 pe2r4_human Human Yes 9.2 IC50 = 0.7 Funct
Inhibitory activity against human EP4 receptor expressed in HEK293 ebna cellsInhibitory activity against human EP4 receptor expressed in HEK293 ebna cells
353 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL3753567 pe2r4_human Human No 9.1 IC50 = 0.7 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
393 5 3 5 3.9 CC1=CC(=CC(=C1NC(=O)C2=C(C=CC(=C2)C3=CC(=CC=C3)CO)F)C)C(=O)O
CHEMBL3753567 pe2r4_human Human No 9.1 IC50 = 0.7 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
393 5 3 5 3.9 CC1=CC(=CC(=C1NC(=O)C2=C(C=CC(=C2)C3=CC(=CC=C3)CO)F)C)C(=O)O
CHEMBL1645135 pe2r4_human Human No 9.0 IC50 = 0.9 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
435 6 2 4 4.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC=C(C=C4)Cl
CHEMBL1645135 pe2r4_human Human No 9.0 IC50 = 0.9 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
435 6 2 4 4.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC=C(C=C4)Cl
CHEMBL1645134 pe2r4_human Human No 9.0 IC50 = 1.1 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
469 6 2 4 5.5 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC(=C(C=C4)Cl)Cl
CHEMBL379746 pe2r4_rat Rat No 9.0 IC50 = 1.1 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
436 10 2 5 4.4 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)Cl)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL1645134 pe2r4_human Human No 9.0 IC50 = 1.1 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
469 6 2 4 5.5 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC(=C(C=C4)Cl)Cl
CHEMBL379746 pe2r4_rat Rat No 9.0 IC50 = 1.1 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
436 10 2 5 4.4 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)Cl)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL3741430 pe2r4_human Human No 9.0 IC50 = 1.1 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
425 5 3 4 5.0 CC1=CC(=CC(=C1NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)CO)C)C(=O)O
CHEMBL3741430 pe2r4_human Human No 9.0 IC50 = 1.1 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
425 5 3 4 5.0 CC1=CC(=CC(=C1NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)CO)C)C(=O)O
CHEMBL1083400 pe2r4_human Human No 9.0 IC50 = 1.1 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
501 6 2 6 5.8 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC(=C2)Cl)C=CN3CC4=CC=C(C=C4)C(F)(F)F
CHEMBL1083400 pe2r4_human Human No 9.0 IC50 = 1.1 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
501 6 2 6 5.8 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC(=C2)Cl)C=CN3CC4=CC=C(C=C4)C(F)(F)F
CHEMBL1644003 pe2r4_human Human No 8.9 IC50 = 1.2 Funct
Antagonist activity at human EP4 receptor in HEK293 cells by cell-based functional assayAntagonist activity at human EP4 receptor in HEK293 cells by cell-based functional assay
550 7 2 5 6.0 CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NCCC2=CC=C(C=C2)C3=C(SC4=C(C=C(C=C34)C)C)C(=O)N(C)C
CHEMBL1644003 pe2r4_human Human No 8.9 IC50 = 1.2 Funct
Antagonist activity at human EP4 receptor in HEK293 cells by cell-based functional assayAntagonist activity at human EP4 receptor in HEK293 cells by cell-based functional assay
550 7 2 5 6.0 CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NCCC2=CC=C(C=C2)C3=C(SC4=C(C=C(C=C34)C)C)C(=O)N(C)C
CHEMBL1086490 pe2r4_human Human No 8.9 IC50 = 1.3 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
513 6 2 6 5.8 C1CC1(C2=CC=C(C=C2)C(=O)O)NC(=O)C3=C4C(=CC(=C3)Cl)C=CN4CC5=CC=C(C=C5)C(F)(F)F
CHEMBL1086490 pe2r4_human Human No 8.9 IC50 = 1.3 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
513 6 2 6 5.8 C1CC1(C2=CC=C(C=C2)C(=O)O)NC(=O)C3=C4C(=CC(=C3)Cl)C=CN4CC5=CC=C(C=C5)C(F)(F)F
CHEMBL1084009 pe2r4_human Human Yes 8.9 IC50 = 1.3 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
478 6 2 6 5.1 C1CC1(C2=CC=C(C=C2)C(=O)O)NC(=O)C3=CC=CC4=C3N(C=C4)CC5=CC=C(C=C5)C(F)(F)F
CHEMBL1645141 pe2r4_human Human No 8.9 IC50 = 1.3 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
477 7 2 4 5.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL1084009 pe2r4_human Human Yes 8.9 IC50 = 1.3 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
478 6 2 6 5.1 C1CC1(C2=CC=C(C=C2)C(=O)O)NC(=O)C3=CC=CC4=C3N(C=C4)CC5=CC=C(C=C5)C(F)(F)F
CHEMBL1645141 pe2r4_human Human No 8.9 IC50 = 1.3 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
477 7 2 4 5.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL1084552 pe2r4_human Human No 8.9 IC50 = 1.4 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
517 7 2 7 6.1 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CC=CC3=C2N(C=C3)CC4=CC(=CC(=C4)Cl)OC(F)(F)F
CHEMBL1084552 pe2r4_human Human No 8.9 IC50 = 1.4 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
517 7 2 7 6.1 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CC=CC3=C2N(C=C3)CC4=CC(=CC(=C4)Cl)OC(F)(F)F
CHEMBL275667 pe2r4_human Human Yes 8.9 IC50 = 1.4 Funct
Inhibitory activity against human EP4 receptor expressed in HEK293 ebna cellsInhibitory activity against human EP4 receptor expressed in HEK293 ebna cells
383 11 2 5 2.6 C1CC(=O)N(C1C=CC(CC2=CC=CC=C2)O)CCCCCCC3=NNN=N3
CHEMBL1085040 pe2r4_human Human No 8.8 IC50 = 1.5 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
467 6 2 3 5.6 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC(=C2)Cl)C=CN3CC4=CC(=CC=C4)Cl
CHEMBL1669013 pe2r4_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
628 10 2 6 6.6 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=C(C=C6)C)C
CHEMBL1085040 pe2r4_human Human No 8.8 IC50 = 1.5 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
467 6 2 3 5.6 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC(=C2)Cl)C=CN3CC4=CC(=CC=C4)Cl
CHEMBL1669013 pe2r4_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
628 10 2 6 6.6 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=C(C=C6)C)C
CHEMBL3753372 pe2r4_human Human No 8.8 IC50 = 1.6 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
395 4 2 4 4.9 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)Cl)C
CHEMBL3753372 pe2r4_human Human No 8.8 IC50 = 1.6 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
395 4 2 4 4.9 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)Cl)C
CHEMBL601299 pe2r4_human Human No 8.8 IC50 = 1.6 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
455 6 2 4 6.4 C1=CC(=CC(=C1)Cl)CC2=C(SC(=C2C(=O)NCC3=CC=C(C=C3)C(=O)O)Cl)Cl
CHEMBL601299 pe2r4_human Human No 8.8 IC50 = 1.6 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
455 6 2 4 6.4 C1=CC(=CC(=C1)Cl)CC2=C(SC(=C2C(=O)NCC3=CC=C(C=C3)C(=O)O)Cl)Cl
CHEMBL3793002 pe2r4_human Human No 8.8 IC50 = 1.6 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
403 4 2 7 4.3 CC1=C(N=C(C=C1)N2CCC(CC2)(F)F)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3793002 pe2r4_human Human No 8.8 IC50 = 1.6 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
403 4 2 7 4.3 CC1=C(N=C(C=C1)N2CCC(CC2)(F)F)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL591431 pe2r4_human Human No 8.7 IC50 = 1.8 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
469 6 2 4 6.8 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(SC(=C2CC3=CC(=CC=C3)Cl)Cl)Cl
CHEMBL1084009 pe2r4_human Human Yes 8.7 IC50 = 1.8 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay in presence of 10% human serumAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay in presence of 10% human serum
478 6 2 6 5.1 C1CC1(C2=CC=C(C=C2)C(=O)O)NC(=O)C3=CC=CC4=C3N(C=C4)CC5=CC=C(C=C5)C(F)(F)F
CHEMBL591431 pe2r4_human Human No 8.8 IC50 = 1.8 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
469 6 2 4 6.8 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(SC(=C2CC3=CC(=CC=C3)Cl)Cl)Cl
CHEMBL1084009 pe2r4_human Human Yes 8.8 IC50 = 1.8 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay in presence of 10% human serumAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay in presence of 10% human serum
478 6 2 6 5.1 C1CC1(C2=CC=C(C=C2)C(=O)O)NC(=O)C3=CC=CC4=C3N(C=C4)CC5=CC=C(C=C5)C(F)(F)F
CHEMBL3753286 pe2r4_human Human No 8.7 IC50 = 1.9 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
444 5 3 8 3.9 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C(F)(F)F
CHEMBL3753286 pe2r4_human Human No 8.7 IC50 = 1.9 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
444 5 3 8 3.9 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C(F)(F)F
CHEMBL591666 pe2r4_human Human Yes 8.0 IC50 = 10 Funct
Displacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cellsDisplacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cells
414 6 2 5 4.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(C=CC(=C2)Cl)OC3=CC=C(C=C3)F
CHEMBL591666 pe2r4_human Human Yes 8.0 IC50 = 10 Funct
Displacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cellsDisplacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cells
414 6 2 5 4.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(C=CC(=C2)Cl)OC3=CC=C(C=C3)F
CHEMBL1669014 pe2r4_human Human No 8.0 IC50 = 10.2 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
618 10 1 4 7.6 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=C(C=C(C=C6)Cl)Cl)C
CHEMBL1669014 pe2r4_human Human No 8.0 IC50 = 10.2 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
618 10 1 4 7.6 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=C(C=C(C=C6)Cl)Cl)C
CHEMBL1910023 pe2r4_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assay
467 4 2 7 5.3 C1CC2=CC=CC(=C2OC3=C1C=CC(=C3)C(F)(F)F)C(=O)NC4(CC4)C5=CC=C(C=C5)C(=O)O
CHEMBL3260422 pe2r4_human Human Yes 6.0 IC50 = 1000 Funct
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation counting
452 7 3 7 2.9 CC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)C(=O)O)S(=O)(=O)NC3=CC=C(C=C3)C(=O)C
CHEMBL3260419 pe2r4_human Human Yes 6.0 IC50 = 1000 Funct
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation counting
308 5 1 4 4.3 CC1=C(C=C(O1)C(=O)O)COC2=CC=C(C=C2)C3=CC=CC=C3
CHEMBL1910023 pe2r4_human Human No 6.0 IC50 = 1000 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assay
467 4 2 7 5.3 C1CC2=CC=CC(=C2OC3=C1C=CC(=C3)C(F)(F)F)C(=O)NC4(CC4)C5=CC=C(C=C5)C(=O)O
CHEMBL3260422 pe2r4_human Human Yes 6.0 IC50 = 1000 Funct
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation counting
452 7 3 7 2.9 CC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)C(=O)O)S(=O)(=O)NC3=CC=C(C=C3)C(=O)C
CHEMBL3260426 pe2r4_human Human No 5.0 IC50 = 10000 Funct
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation counting
308 5 1 4 4.3 CC1=C(C=C(O1)C(=O)O)COC2=CC=CC(=C2)C3=CC=CC=C3
CHEMBL521777 pe2r4_human Human No 5.0 IC50 = 10000 Funct
Displacement of radioligand from EP4 receptorDisplacement of radioligand from EP4 receptor
539 6 1 8 5.4 CN1C=C(C2=C1C=CC=C2OC3=CC(=C(C=C3)Cl)F)C=CC(=O)NS(=O)(=O)C4=C(C=C(C(=C4)F)F)F
CHEMBL3260426 pe2r4_human Human No 5.0 IC50 = 10000 Funct
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation counting
308 5 1 4 4.3 CC1=C(C=C(O1)C(=O)O)COC2=CC=CC(=C2)C3=CC=CC=C3
CHEMBL521777 pe2r4_human Human No 5.0 IC50 = 10000 Funct
Displacement of radioligand from EP4 receptorDisplacement of radioligand from EP4 receptor
539 6 1 8 5.4 CN1C=C(C2=C1C=CC=C2OC3=CC(=C(C=C3)Cl)F)C=CC(=O)NS(=O)(=O)C4=C(C=C(C(=C4)F)F)F
CHEMBL565992 pe2r4_human Human No 5.0 IC50 = 10172 Funct
Displacement of [3H]PGE2 from human EP4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor after 1 hr by liquid scintillation counting
565 7 1 6 6.3 C1=CC2=C(C(=C1)OCC(=O)NS(=O)(=O)C3=CC(=C(S3)Cl)Cl)N(C=N2)CC4=C(C=C(C=C4)Cl)Cl
CHEMBL565992 pe2r4_human Human No 5.0 IC50 = 10172 Funct
Displacement of [3H]PGE2 from human EP4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor after 1 hr by liquid scintillation counting
565 7 1 6 6.3 C1=CC2=C(C(=C1)OCC(=O)NS(=O)(=O)C3=CC(=C(S3)Cl)Cl)N(C=N2)CC4=C(C=C(C=C4)Cl)Cl
CHEMBL1669005 pe2r4_human Human No 7.0 IC50 = 102 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 releaseAntagonist activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 release
674 12 2 8 6.2 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6OC)OC)C
CHEMBL1669005 pe2r4_human Human No 7.0 IC50 = 102 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 releaseAntagonist activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 release
674 12 2 8 6.2 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6OC)OC)C
CHEMBL1669003 pe2r4_human Human No 7.0 IC50 = 103 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
773 10 2 13 8.0 CC1=C(C=CC(=C1)CC2(CC2)NC(=O)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3)N5CC6=C(C7=C(C=CC=N7)C(=C6C5=O)OCC(F)(F)F)OCC(F)(F)F
CHEMBL1669003 pe2r4_human Human No 7.0 IC50 = 103 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
773 10 2 13 8.0 CC1=C(C=CC(=C1)CC2(CC2)NC(=O)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3)N5CC6=C(C7=C(C=CC=N7)C(=C6C5=O)OCC(F)(F)F)OCC(F)(F)F
CHEMBL597997 pe2r4_human Human Yes 8.0 IC50 = 11 Funct
Activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 releaseActivity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 release
474 6 2 7 5.9 CC1=C(C(=C(S1)C)C(=O)NC2(CC2)C3=CC=C(C=C3)C(=O)O)CC4=CC=C(C=C4)C(F)(F)F
CHEMBL597997 pe2r4_human Human Yes 8.0 IC50 = 11 Funct
Activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 releaseActivity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 release
474 6 2 7 5.9 CC1=C(C(=C(S1)C)C(=O)NC2(CC2)C3=CC=C(C=C3)C(=O)O)CC4=CC=C(C=C4)C(F)(F)F
CHEMBL3741642 pe2r4_human Human No 8.0 IC50 = 11.2 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
396 4 2 4 4.9 CC1=CC(=CC(=C1NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC=CC=C4)C)C(=O)O
CHEMBL3741642 pe2r4_human Human No 8.0 IC50 = 11.2 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
396 4 2 4 4.9 CC1=CC(=CC(=C1NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC=CC=C4)C)C(=O)O
CHEMBL3039498 pe2r4_human Human Yes 7.9 IC50 = 11.7 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
492 7 2 5 4.6 CCC1=NC2=C(N=C(C=C2N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C)C
CHEMBL3039498 pe2r4_human Human Yes 7.9 IC50 = 11.7 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
492 7 2 5 4.6 CCC1=NC2=C(N=C(C=C2N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C)C
CHEMBL3039498 pe2r4_human Human Yes 7.9 IC50 = 11.7 Funct
Antagonist activity at recombinant human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP accumulation by scintillation proximity assay in presence of [125I]-cAMPAntagonist activity at recombinant human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP accumulation by scintillation proximity assay in presence of [125I]-cAMP
492 7 2 5 4.6 CCC1=NC2=C(N=C(C=C2N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C)C
CHEMBL3039498 pe2r4_human Human Yes 7.9 IC50 = 11.7 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
492 7 2 5 4.6 CCC1=NC2=C(N=C(C=C2N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C)C
CHEMBL3039498 pe2r4_human Human Yes 7.9 IC50 = 11.7 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
492 7 2 5 4.6 CCC1=NC2=C(N=C(C=C2N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C)C
CHEMBL3039498 pe2r4_human Human Yes 7.9 IC50 = 11.7 Funct
Antagonist activity at recombinant human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP accumulation by scintillation proximity assay in presence of [125I]-cAMPAntagonist activity at recombinant human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP accumulation by scintillation proximity assay in presence of [125I]-cAMP
492 7 2 5 4.6 CCC1=NC2=C(N=C(C=C2N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C)C
CHEMBL1084551 pe2r4_human Human No 7.9 IC50 = 11.8 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
466 6 2 6 5.2 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CC=CC3=C2N(C=C3)CC4=CC(=CC=C4)C(F)(F)F
CHEMBL1084551 pe2r4_human Human No 7.9 IC50 = 11.8 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
466 6 2 6 5.2 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CC=CC3=C2N(C=C3)CC4=CC(=CC=C4)C(F)(F)F
CHEMBL1645147 pe2r4_human Human No 6.9 IC50 = 114 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
457 7 2 4 5.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC=C(C=C4)C(C)(C)C
CHEMBL1645147 pe2r4_human Human No 6.9 IC50 = 114 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
457 7 2 4 5.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC=C(C=C4)C(C)(C)C
CHEMBL3793002 pe2r4_human Human No 5.9 IC50 = 1160 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
403 4 2 7 4.3 CC1=C(N=C(C=C1)N2CCC(CC2)(F)F)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3793002 pe2r4_human Human No 5.9 IC50 = 1160 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
403 4 2 7 4.3 CC1=C(N=C(C=C1)N2CCC(CC2)(F)F)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3686863 pe2r4_rat Rat No 7.9 IC50 = 12 Funct
Antagonist activity against rat EP4 assessed as inhibition of PGE2-stimulated production of cAMPAntagonist activity against rat EP4 assessed as inhibition of PGE2-stimulated production of cAMP
383 4 3 6 3.0 CC1=C(N=C(C=C1)N2CCC(CC2)O)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL599051 pe2r4_human Human No 7.9 IC50 = 12 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
400 6 2 4 4.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CSC=C2CC3=CC(=CC=C3)Cl
CHEMBL3686863 pe2r4_rat Rat No 7.9 IC50 = 12 Funct
Antagonist activity against rat EP4 assessed as inhibition of PGE2-stimulated production of cAMPAntagonist activity against rat EP4 assessed as inhibition of PGE2-stimulated production of cAMP
383 4 3 6 3.0 CC1=C(N=C(C=C1)N2CCC(CC2)O)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL599051 pe2r4_human Human No 7.9 IC50 = 12 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
400 6 2 4 4.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CSC=C2CC3=CC(=CC=C3)Cl
CHEMBL3260420 pe2r4_human Human No 5.9 IC50 = 1200 Funct
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation counting
363 4 1 5 4.9 CC(C)C1=C(C=NN1C2=NC(=CS2)C3=CC4=CC=CC=C4C=C3)C(=O)O
CHEMBL3260420 pe2r4_human Human No 5.9 IC50 = 1200 Funct
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation counting
363 4 1 5 4.9 CC(C)C1=C(C=NN1C2=NC(=CS2)C3=CC4=CC=CC=C4C=C3)C(=O)O
CHEMBL203076 pe2r4_rat Rat No 5.9 IC50 = 1202 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
377 12 3 5 2.7 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)O)O)CCCCCCC(=O)O
CHEMBL203076 pe2r4_rat Rat No 5.9 IC50 = 1202 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
377 12 3 5 2.7 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)O)O)CCCCCCC(=O)O
CHEMBL3752948 pe2r4_human Human No 6.9 IC50 = 121 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
444 5 3 8 3.9 CC1=CC(=CC(=C1NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C(F)(F)F)C)C(=O)O
CHEMBL3752948 pe2r4_human Human No 6.9 IC50 = 121 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
444 5 3 8 3.9 CC1=CC(=CC(=C1NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C(F)(F)F)C)C(=O)O
CHEMBL3686863 pe2r4_human Human No 6.9 IC50 = 123 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
383 4 3 6 3.0 CC1=C(N=C(C=C1)N2CCC(CC2)O)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3686863 pe2r4_human Human No 6.9 IC50 = 123 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
383 4 3 6 3.0 CC1=C(N=C(C=C1)N2CCC(CC2)O)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL521609 pe2r4_human Human No 4.9 IC50 = 12500 Funct
Displacement of radioligand from EP4 receptorDisplacement of radioligand from EP4 receptor
519 6 1 6 5.8 CN1C=C(C2=C1C=CC=C2OC3=CC4=CC=CC=C4C=C3)C=CC(=O)NS(=O)(=O)C5=CC(=C(C=C5)F)F
CHEMBL521609 pe2r4_human Human No 4.9 IC50 = 12500 Funct
Displacement of radioligand from EP4 receptorDisplacement of radioligand from EP4 receptor
519 6 1 6 5.8 CN1C=C(C2=C1C=CC=C2OC3=CC4=CC=CC=C4C=C3)C=CC(=O)NS(=O)(=O)C5=CC(=C(C=C5)F)F
CHEMBL208080 pe2r4_rat Rat No 6.9 IC50 = 126 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
413 10 2 5 3.8 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)F)O)CCCC3=CC=C(C=C3)C(=O)O
CHEMBL208080 pe2r4_rat Rat No 6.9 IC50 = 126 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
413 10 2 5 3.8 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)F)O)CCCC3=CC=C(C=C3)C(=O)O
CHEMBL3741710 pe2r4_human Human Yes 6.9 IC50 = 128 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
352 3 1 2 5.4 CC1=C(C(=CC=C1)C)NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC=CC=C4
CHEMBL3741710 pe2r4_human Human Yes 6.9 IC50 = 128 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
352 3 1 2 5.4 CC1=C(C(=CC=C1)C)NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC=CC=C4
CHEMBL591666 pe2r4_human Human Yes 7.9 IC50 = 13 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assay
414 6 2 5 4.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(C=CC(=C2)Cl)OC3=CC=C(C=C3)F
CHEMBL591666 pe2r4_human Human Yes 7.9 IC50 = 13 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assay
414 6 2 5 4.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(C=CC(=C2)Cl)OC3=CC=C(C=C3)F
CHEMBL475348 pe2r4_human Human No 4.9 IC50 = 13000 Funct
Displacement of radioligand from EP4 receptorDisplacement of radioligand from EP4 receptor
555 6 1 7 5.9 CN1C=C(C2=C1C=CC=C2OC3=CC(=C(C=C3)Cl)Cl)C=CC(=O)NS(=O)(=O)C4=C(C=C(C(=C4)F)F)F
CHEMBL475348 pe2r4_human Human No 4.9 IC50 = 13000 Funct
Displacement of radioligand from EP4 receptorDisplacement of radioligand from EP4 receptor
555 6 1 7 5.9 CN1C=C(C2=C1C=CC=C2OC3=CC(=C(C=C3)Cl)Cl)C=CC(=O)NS(=O)(=O)C4=C(C=C(C(=C4)F)F)F
CHEMBL3741430 pe2r4_human Human No 6.9 IC50 = 136 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay
425 5 3 4 5.0 CC1=CC(=CC(=C1NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)CO)C)C(=O)O
CHEMBL3741430 pe2r4_human Human No 6.9 IC50 = 136 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay
425 5 3 4 5.0 CC1=CC(=CC(=C1NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)CO)C)C(=O)O
CHEMBL1669010 pe2r4_human Human No 7.9 IC50 = 14 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
628 10 2 6 6.6 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6C)C
CHEMBL1669008 pe2r4_human Human No 7.9 IC50 = 14 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
683 10 2 6 7.5 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6Cl)Cl)C
CHEMBL1669010 pe2r4_human Human No 7.9 IC50 = 14 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
628 10 2 6 6.6 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6C)C
CHEMBL1669008 pe2r4_human Human No 7.9 IC50 = 14 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
683 10 2 6 7.5 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6Cl)Cl)C
CHEMBL3793928 pe2r4_human Human No 7.9 IC50 = 14.2 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
397 5 3 6 3.2 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)N3CCCC(C3)CO)C
CHEMBL3793928 pe2r4_human Human No 7.9 IC50 = 14.2 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
397 5 3 6 3.2 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)N3CCCC(C3)CO)C
CHEMBL425950 pe2r4_rat Rat No 6.9 IC50 = 140 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
430 11 2 5 4.6 CCC1=CC=C(C=C1)CC(CCC2CCC(=O)N2CCCC3=CC=C(S3)C(=O)O)O
CHEMBL425950 pe2r4_rat Rat No 6.9 IC50 = 140 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
430 11 2 5 4.6 CCC1=CC=C(C=C1)CC(CCC2CCC(=O)N2CCCC3=CC=C(S3)C(=O)O)O
CHEMBL3792709 pe2r4_human Human No 5.8 IC50 = 1450 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
383 4 3 6 3.0 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)N3CCC(CC3)O)C
CHEMBL3793956 pe2r4_human Human No 5.8 IC50 = 1450 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
397 5 3 6 3.2 CC1=C(N=C(C=C1)N2CCCC(C2)CO)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3792709 pe2r4_human Human No 5.8 IC50 = 1450 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
383 4 3 6 3.0 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)N3CCC(CC3)O)C
CHEMBL3793956 pe2r4_human Human No 5.8 IC50 = 1450 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
397 5 3 6 3.2 CC1=C(N=C(C=C1)N2CCCC(C2)CO)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL459885 pe2r4_human Human No 4.8 IC50 = 14600 Funct
Displacement of radioligand from EP4 receptorDisplacement of radioligand from EP4 receptor
537 6 1 6 5.8 CN1C=C(C2=C1C=CC=C2OC3=C(C=C(C=C3)Cl)Cl)C=CC(=O)NS(=O)(=O)C4=CC(=C(C=C4)F)F
CHEMBL459885 pe2r4_human Human No 4.8 IC50 = 14600 Funct
Displacement of radioligand from EP4 receptorDisplacement of radioligand from EP4 receptor
537 6 1 6 5.8 CN1C=C(C2=C1C=CC=C2OC3=C(C=C(C=C3)Cl)Cl)C=CC(=O)NS(=O)(=O)C4=CC(=C(C=C4)F)F
CHEMBL1093791 pe2r4_human Human No 4.8 IC50 = 15100 Funct
Binding affinity to human EP4 receptor by radioligand displacement assayBinding affinity to human EP4 receptor by radioligand displacement assay
517 6 2 6 4.1 C1=CC=C2C=C(C=CC2=C1)CN3C(=O)C(C4=CC=CC(=C43)C=CC(=O)NS(=O)(=O)C5=CC=C(C=C5)F)O
CHEMBL1093791 pe2r4_human Human No 4.8 IC50 = 15100 Funct
Binding affinity to human EP4 receptor by radioligand displacement assayBinding affinity to human EP4 receptor by radioligand displacement assay
517 6 2 6 4.1 C1=CC=C2C=C(C=CC2=C1)CN3C(=O)C(C4=CC=CC(=C43)C=CC(=O)NS(=O)(=O)C5=CC=C(C=C5)F)O
CHEMBL3039498 pe2r4_human Human Yes 5.8 IC50 = 1520 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
492 7 2 5 4.6 CCC1=NC2=C(N=C(C=C2N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C)C
CHEMBL3039498 pe2r4_human Human Yes 5.8 IC50 = 1520 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay
492 7 2 5 4.6 CCC1=NC2=C(N=C(C=C2N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C)C
CHEMBL3039498 pe2r4_human Human Yes 5.8 IC50 = 1520 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
492 7 2 5 4.6 CCC1=NC2=C(N=C(C=C2N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C)C
CHEMBL3039498 pe2r4_human Human Yes 5.8 IC50 = 1520 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay
492 7 2 5 4.6 CCC1=NC2=C(N=C(C=C2N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C)C
CHEMBL427844 pe2r4_human Human No 6.8 IC50 = 158.5 Funct
Inhibition of EP4 receptorInhibition of EP4 receptor
555 7 2 6 5.4 CC1=CC=C(N1C2=CC(=CC(=C2)C(=O)O)NC(=O)C)C3=C(C=CC(=C3)Br)OCC4=C(C=C(C=C4)F)F
CHEMBL427844 pe2r4_human Human No 6.8 IC50 = 158.5 Funct
Inhibition of EP4 receptorInhibition of EP4 receptor
555 7 2 6 5.4 CC1=CC=C(N1C2=CC(=CC(=C2)C(=O)O)NC(=O)C)C3=C(C=CC(=C3)Br)OCC4=C(C=C(C=C4)F)F
CHEMBL231184 pe2r4_human Human No 4.8 IC50 = 15848.9 Funct
Binding affinity to human EP4 receptor expressed in CHO cellsBinding affinity to human EP4 receptor expressed in CHO cells
450 6 1 4 6.5 CC1=C(C=C(C=C1)N2C(=CC=C2C3=C(C=CC(=C3)Cl)OCC4=CC=C(C=C4)F)C)C(=O)O
CHEMBL1669018 pe2r4_human Human No 7.8 IC50 = 16 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
579 11 1 5 6.3 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=CC=CC=C6OC)C
CHEMBL1669018 pe2r4_human Human No 7.8 IC50 = 16 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
579 11 1 5 6.3 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=CC=CC=C6OC)C
CHEMBL3793956 pe2r4_human Human No 7.8 IC50 = 16.5 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
397 5 3 6 3.2 CC1=C(N=C(C=C1)N2CCCC(C2)CO)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3793956 pe2r4_human Human No 7.8 IC50 = 16.5 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
397 5 3 6 3.2 CC1=C(N=C(C=C1)N2CCCC(C2)CO)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3039498 pe2r4_human Human Yes 5.8 IC50 = 1600 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
492 7 2 5 4.6 CCC1=NC2=C(N=C(C=C2N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C)C
CHEMBL379785 pe2r4_rat Rat No 5.8 IC50 = 1600 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
478 11 2 5 5.4 C1CC(=O)N(C1CCC(CC2=CC=CC=C2C3=CC=CC=C3)O)CCCC4=CC=C(S4)C(=O)O
CHEMBL3039498 pe2r4_human Human Yes 5.8 IC50 = 1600 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
492 7 2 5 4.6 CCC1=NC2=C(N=C(C=C2N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C)C
CHEMBL379785 pe2r4_rat Rat No 5.8 IC50 = 1600 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
478 11 2 5 5.4 C1CC(=O)N(C1CCC(CC2=CC=CC=C2C3=CC=CC=C3)O)CCCC4=CC=C(S4)C(=O)O
CHEMBL3039498 pe2r4_human Human Yes 5.8 IC50 = 1614 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha reduction preincubated for 30 mins followed by PGE2 addition measured after 24 hrs by ELISAAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha reduction preincubated for 30 mins followed by PGE2 addition measured after 24 hrs by ELISA
492 7 2 5 4.6 CCC1=NC2=C(N=C(C=C2N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C)C
CHEMBL3039498 pe2r4_human Human Yes 5.8 IC50 = 1614 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha reduction preincubated for 30 mins followed by PGE2 addition measured after 24 hrs by ELISAAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha reduction preincubated for 30 mins followed by PGE2 addition measured after 24 hrs by ELISA
492 7 2 5 4.6 CCC1=NC2=C(N=C(C=C2N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C)C
CHEMBL1669009 pe2r4_human Human No 6.8 IC50 = 162 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 releaseAntagonist activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 release
644 11 2 7 6.2 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6OC)C
CHEMBL1669009 pe2r4_human Human No 6.8 IC50 = 162 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 releaseAntagonist activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 release
644 11 2 7 6.2 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6OC)C
CHEMBL378968 pe2r4_rat Rat No 7.8 IC50 = 17 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
420 10 2 6 3.9 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)F)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL1669013 pe2r4_human Human No 7.8 IC50 = 17 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
628 10 2 6 6.6 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=C(C=C6)C)C
CHEMBL378968 pe2r4_rat Rat No 7.8 IC50 = 17 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
420 10 2 6 3.9 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)F)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL1669013 pe2r4_human Human No 7.8 IC50 = 17 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
628 10 2 6 6.6 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=C(C=C6)C)C
CHEMBL3753860 pe2r4_human Human No 7.7 IC50 = 18.7 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
389 5 3 4 4.1 CC1=C(C=C(C=C1)C2=CC(=CC=C2)CO)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3753860 pe2r4_human Human No 7.7 IC50 = 18.7 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
389 5 3 4 4.1 CC1=C(C=C(C=C1)C2=CC(=CC=C2)CO)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3586359 pe2r4_human Human No 4.8 IC50 = 18000 Funct
Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay
423 3 1 4 4.1 C1COC2=C(CN1CC3=CC(=O)NC=C3)C=C(C=C2Cl)C4=CSC5=CC=CC=C54
CHEMBL3586359 pe2r4_human Human No 4.8 IC50 = 18000 Funct
Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay
423 3 1 4 4.1 C1COC2=C(CN1CC3=CC(=O)NC=C3)C=C(C=C2Cl)C4=CSC5=CC=CC=C54
CHEMBL1081186 pe2r4_human Human No 4.7 IC50 = 18600 Funct
Binding affinity to human EP4 receptor by radioligand displacement assayBinding affinity to human EP4 receptor by radioligand displacement assay
566 6 1 8 6.5 CC1=CN(C2=C(C=C(C=C12)F)C3=CC(=NO3)NS(=O)(=O)C4=CC(=C(C=C4)F)F)CC5=C(C=C(C=C5)Cl)Cl
CHEMBL1081186 pe2r4_human Human No 4.7 IC50 = 18600 Funct
Binding affinity to human EP4 receptor by radioligand displacement assayBinding affinity to human EP4 receptor by radioligand displacement assay
566 6 1 8 6.5 CC1=CN(C2=C(C=C(C=C12)F)C3=CC(=NO3)NS(=O)(=O)C4=CC(=C(C=C4)F)F)CC5=C(C=C(C=C5)Cl)Cl
CHEMBL1669026 pe2r4_human Human No 7.7 IC50 = 19 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
642 10 2 6 7.0 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6C)C)C
CHEMBL1669026 pe2r4_human Human No 7.7 IC50 = 19 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
642 10 2 6 7.0 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6C)C)C
CHEMBL3792709 pe2r4_human Human No 7.7 IC50 = 19.5 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
383 4 3 6 3.0 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)N3CCC(CC3)O)C
CHEMBL3792709 pe2r4_human Human No 7.7 IC50 = 19.5 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
383 4 3 6 3.0 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)N3CCC(CC3)O)C
CHEMBL3741642 pe2r4_human Human No 5.7 IC50 = 1980 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay
396 4 2 4 4.9 CC1=CC(=CC(=C1NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC=CC=C4)C)C(=O)O
CHEMBL3741642 pe2r4_human Human No 5.7 IC50 = 1980 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay
396 4 2 4 4.9 CC1=CC(=CC(=C1NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC=CC=C4)C)C(=O)O
CHEMBL1910022 pe2r4_human Human No 8.7 IC50 = 2 Funct
Displacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cellsDisplacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cells
455 4 2 7 5.3 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCC4=C(O3)C=C(C=C4)C(F)(F)F
CHEMBL1669025 pe2r4_human Human No 8.7 IC50 = 2 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
683 10 2 6 7.5 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C(=CC=C6)Cl)Cl)C
CHEMBL1910022 pe2r4_human Human No 8.7 IC50 = 2 Funct
Displacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cellsDisplacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cells
455 4 2 7 5.3 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCC4=C(O3)C=C(C=C4)C(F)(F)F
CHEMBL1669025 pe2r4_human Human No 8.7 IC50 = 2 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
683 10 2 6 7.5 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C(=CC=C6)Cl)Cl)C
CHEMBL1645137 pe2r4_human Human No 8.7 IC50 = 2.1 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
468 6 2 7 5.2 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC=C(C=C4)C(F)(F)F
CHEMBL1645155 pe2r4_human Human No 8.7 IC50 = 2.1 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
486 6 2 8 5.3 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CC(=CC3=C2N(CC3)CC4=CC=C(C=C4)C(F)(F)F)F
CHEMBL1669014 pe2r4_human Human No 8.7 IC50 = 2.1 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
618 10 1 4 7.6 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=C(C=C(C=C6)Cl)Cl)C
CHEMBL548 pe2r4_rat Rat Yes 8.7 IC50 = 2.1 Funct
Inhibition of rat EP4 receptor expressed in HEK293 cellsInhibition of rat EP4 receptor expressed in HEK293 cells
353 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL1645137 pe2r4_human Human No 8.7 IC50 = 2.1 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
468 6 2 7 5.2 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC=C(C=C4)C(F)(F)F
CHEMBL1645155 pe2r4_human Human No 8.7 IC50 = 2.1 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
486 6 2 8 5.3 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CC(=CC3=C2N(CC3)CC4=CC=C(C=C4)C(F)(F)F)F
CHEMBL1669014 pe2r4_human Human No 8.7 IC50 = 2.1 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
618 10 1 4 7.6 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=C(C=C(C=C6)Cl)Cl)C
CHEMBL548 pe2r4_rat Rat Yes 8.7 IC50 = 2.1 Funct
Inhibition of rat EP4 receptor expressed in HEK293 cellsInhibition of rat EP4 receptor expressed in HEK293 cells
353 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL1645153 pe2r4_human Human No 8.7 IC50 = 2.2 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
503 6 2 7 5.8 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CC(=CC3=C2N(CC3)CC4=CC=C(C=C4)C(F)(F)F)Cl
CHEMBL1669004 pe2r4_human Human No 8.7 IC50 = 2.2 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
693 10 2 6 6.9 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6Br)C
CHEMBL1645153 pe2r4_human Human No 8.7 IC50 = 2.2 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
503 6 2 7 5.8 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CC(=CC3=C2N(CC3)CC4=CC=C(C=C4)C(F)(F)F)Cl
CHEMBL1669004 pe2r4_human Human No 8.7 IC50 = 2.2 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
693 10 2 6 6.9 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6Br)C
CHEMBL598198 pe2r4_human Human No 8.6 IC50 = 2.3 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
498 6 2 8 5.5 CC1=C(C(=C(S1)C)C(=O)NC2(CC2)C3=CC=C(C=C3)C4=NNN=N4)CC5=CC=C(C=C5)C(F)(F)F
CHEMBL598198 pe2r4_human Human No 8.6 IC50 = 2.3 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
498 6 2 8 5.5 CC1=C(C(=C(S1)C)C(=O)NC2(CC2)C3=CC=C(C=C3)C4=NNN=N4)CC5=CC=C(C=C5)C(F)(F)F
CHEMBL3753274 pe2r4_human Human No 8.6 IC50 = 2.3 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
389 5 3 4 4.1 CC1=C(C=C(C=C1)C2=CC(=CC=C2)CO)C(=O)NC3=C(C=CC(=C3C)C(=O)O)C
CHEMBL3753274 pe2r4_human Human No 8.6 IC50 = 2.3 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
389 5 3 4 4.1 CC1=C(C=C(C=C1)C2=CC(=CC=C2)CO)C(=O)NC3=C(C=CC(=C3C)C(=O)O)C
CHEMBL3754085 pe2r4_human Human Yes 8.6 IC50 = 2.4 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
390 5 3 5 3.4 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C
CHEMBL3754085 pe2r4_human Human Yes 8.6 IC50 = 2.4 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
390 5 3 5 3.4 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C
CHEMBL3754085 pe2r4_human Human Yes 8.6 IC50 = 2.4 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
390 5 3 5 3.4 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C
CHEMBL3754085 pe2r4_human Human Yes 8.6 IC50 = 2.4 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
390 5 3 5 3.4 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C
CHEMBL1644016 pe2r4_human Human No 8.6 IC50 = 2.4 Funct
Antagonist activity at human EP4 receptor in HEK293 cells by cell-based functional assayAntagonist activity at human EP4 receptor in HEK293 cells by cell-based functional assay
501 8 1 4 6.2 CC1=CC(=C2C(=C1)C(=C(S2)C(=O)N(C)C)C3=CC=C(C=C3)CCNC(=O)CC4=CC=CC=C4OC)C
CHEMBL1669012 pe2r4_human Human No 8.6 IC50 = 2.4 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
648 10 2 6 6.9 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6Cl)C
CHEMBL1644016 pe2r4_human Human No 8.6 IC50 = 2.4 Funct
Antagonist activity at human EP4 receptor in HEK293 cells by cell-based functional assayAntagonist activity at human EP4 receptor in HEK293 cells by cell-based functional assay
501 8 1 4 6.2 CC1=CC(=C2C(=C1)C(=C(S2)C(=O)N(C)C)C3=CC=C(C=C3)CCNC(=O)CC4=CC=CC=C4OC)C
CHEMBL1669012 pe2r4_human Human No 8.6 IC50 = 2.4 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
648 10 2 6 6.9 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6Cl)C
CHEMBL3740223 pe2r4_human Human No 8.6 IC50 = 2.4 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
425 5 3 4 5.0 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)CO
CHEMBL3740223 pe2r4_human Human No 8.6 IC50 = 2.4 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
425 5 3 4 5.0 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)CO
CHEMBL3740223 pe2r4_human Human No 8.6 IC50 = 2.4 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
425 5 3 4 5.0 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)CO
CHEMBL3740223 pe2r4_human Human No 8.6 IC50 = 2.4 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
425 5 3 4 5.0 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)CO
CHEMBL597997 pe2r4_human Human Yes 8.6 IC50 = 2.5 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
474 6 2 7 5.9 CC1=C(C(=C(S1)C)C(=O)NC2(CC2)C3=CC=C(C=C3)C(=O)O)CC4=CC=C(C=C4)C(F)(F)F
CHEMBL1669007 pe2r4_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
664 10 2 6 7.5 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC7=CC=CC=C7C=C6)C
CHEMBL597997 pe2r4_human Human Yes 8.6 IC50 = 2.5 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
474 6 2 7 5.9 CC1=C(C(=C(S1)C)C(=O)NC2(CC2)C3=CC=C(C=C3)C(=O)O)CC4=CC=C(C=C4)C(F)(F)F
CHEMBL1669007 pe2r4_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
664 10 2 6 7.5 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC7=CC=CC=C7C=C6)C
CHEMBL1084553 pe2r4_human Human No 8.6 IC50 = 2.7 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
466 6 2 6 5.2 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CC=CC3=C2N(C=C3)CC4=CC=C(C=C4)C(F)(F)F
CHEMBL1084553 pe2r4_human Human No 8.6 IC50 = 2.7 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
466 6 2 6 5.2 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CC=CC3=C2N(C=C3)CC4=CC=C(C=C4)C(F)(F)F
CHEMBL1645139 pe2r4_human Human No 8.6 IC50 = 2.8 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
484 7 2 8 5.5 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC=C(C=C4)OC(F)(F)F
CHEMBL1645139 pe2r4_human Human No 8.6 IC50 = 2.8 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
484 7 2 8 5.5 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC=C(C=C4)OC(F)(F)F
CHEMBL597997 pe2r4_human Human Yes 8.5 IC50 = 2.9 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay in presence of 10% human serumAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay in presence of 10% human serum
474 6 2 7 5.9 CC1=C(C(=C(S1)C)C(=O)NC2(CC2)C3=CC=C(C=C3)C(=O)O)CC4=CC=C(C=C4)C(F)(F)F
CHEMBL597997 pe2r4_human Human Yes 8.5 IC50 = 2.9 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay in presence of 10% human serumAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay in presence of 10% human serum
474 6 2 7 5.9 CC1=C(C(=C(S1)C)C(=O)NC2(CC2)C3=CC=C(C=C3)C(=O)O)CC4=CC=C(C=C4)C(F)(F)F
CHEMBL1910022 pe2r4_human Human No 7.7 IC50 = 20 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assay
455 4 2 7 5.3 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCC4=C(O3)C=C(C=C4)C(F)(F)F
CHEMBL1910022 pe2r4_human Human No 7.7 IC50 = 20 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assay
455 4 2 7 5.3 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCC4=C(O3)C=C(C=C4)C(F)(F)F
CHEMBL3586362 pe2r4_human Human No 4.7 IC50 = 20000 Funct
Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay
438 3 1 4 3.7 CC1COC2=C(C=C(C=C2CN1CC3=CC(=O)NC=C3)N4C=CC5=C4C=CC(=C5)F)Cl
CHEMBL3586362 pe2r4_human Human No 4.7 IC50 = 20000 Funct
Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay
438 3 1 4 3.7 CC1COC2=C(C=C(C=C2CN1CC3=CC(=O)NC=C3)N4C=CC5=C4C=CC(=C5)F)Cl
CHEMBL489310 pe2r4_human Human No 4.7 IC50 = 20400 Funct
Displacement of radioligand from EP4 receptorDisplacement of radioligand from EP4 receptor
537 6 1 6 5.8 CN1C=C(C2=C1C=CC=C2OC3=CC(=C(C=C3)Cl)Cl)C=CC(=O)NS(=O)(=O)C4=CC(=C(C=C4)F)F
CHEMBL489310 pe2r4_human Human No 4.7 IC50 = 20400 Funct
Displacement of radioligand from EP4 receptorDisplacement of radioligand from EP4 receptor
537 6 1 6 5.8 CN1C=C(C2=C1C=CC=C2OC3=CC(=C(C=C3)Cl)Cl)C=CC(=O)NS(=O)(=O)C4=CC(=C(C=C4)F)F
CHEMBL479439 pe2r4_human Human No 4.7 IC50 = 20800 Funct
Binding affinity to human EP4 receptor by radioligand binding assayBinding affinity to human EP4 receptor by radioligand binding assay
573 6 1 7 4.8 CC12CCCC(=C1N(C(=O)C2)CC3=C(C=C(C=C3)Cl)Cl)C=CC(=O)NS(=O)(=O)C4=C(C=C(C(=C4)F)F)F
CHEMBL482018 pe2r4_human Human No 4.7 IC50 = 20800 Funct
Binding affinity to human EP4 receptor by radioligand binding assayBinding affinity to human EP4 receptor by radioligand binding assay
573 6 1 7 4.8 CC12CCCC(=C1N(C(=O)C2)CC3=C(C(=CC=C3)Cl)Cl)C=CC(=O)NS(=O)(=O)C4=C(C=C(C(=C4)F)F)F
CHEMBL479439 pe2r4_human Human No 4.7 IC50 = 20800 Funct
Binding affinity to human EP4 receptor by radioligand binding assayBinding affinity to human EP4 receptor by radioligand binding assay
573 6 1 7 4.8 CC12CCCC(=C1N(C(=O)C2)CC3=C(C=C(C=C3)Cl)Cl)C=CC(=O)NS(=O)(=O)C4=C(C=C(C(=C4)F)F)F
CHEMBL482018 pe2r4_human Human No 4.7 IC50 = 20800 Funct
Binding affinity to human EP4 receptor by radioligand binding assayBinding affinity to human EP4 receptor by radioligand binding assay
573 6 1 7 4.8 CC12CCCC(=C1N(C(=O)C2)CC3=C(C(=CC=C3)Cl)Cl)C=CC(=O)NS(=O)(=O)C4=C(C=C(C(=C4)F)F)F
CHEMBL382029 pe2r4_rat Rat No 7.7 IC50 = 21 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
402 10 2 5 3.8 C1CC(=O)N(C1CCC(CC2=CC=CC=C2)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL46395 pe2r4_rat Rat No 7.7 IC50 = 21 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
429 12 2 7 3.9 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCCCCC(=O)O
CHEMBL1669005 pe2r4_human Human No 7.7 IC50 = 21 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
674 12 2 8 6.2 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6OC)OC)C
CHEMBL382029 pe2r4_rat Rat No 7.7 IC50 = 21 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
402 10 2 5 3.8 C1CC(=O)N(C1CCC(CC2=CC=CC=C2)O)CCCC3=CC=C(S3)C(=O)O
CHEMBL46395 pe2r4_rat Rat No 7.7 IC50 = 21 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
429 12 2 7 3.9 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)C(F)(F)F)O)CCCCCCC(=O)O
CHEMBL1669005 pe2r4_human Human No 7.7 IC50 = 21 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
674 12 2 8 6.2 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6OC)OC)C
CHEMBL383339 pe2r4_rat Rat No 6.7 IC50 = 210 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
420 15 2 5 3.1 COCCC1=CC(=CC=C1)CC(CCC2CCC(=O)N2CCCCCCC(=O)O)O
CHEMBL383339 pe2r4_rat Rat No 6.7 IC50 = 210 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
420 15 2 5 3.1 COCCC1=CC(=CC=C1)CC(CCC2CCC(=O)N2CCCCCCC(=O)O)O
CHEMBL1645151 pe2r4_human Human No 6.7 IC50 = 212 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
425 6 2 5 4.0 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC=CC(=C4)C#N
CHEMBL1645151 pe2r4_human Human No 6.7 IC50 = 212 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
425 6 2 5 4.0 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CC=CC(=C4)C#N
CHEMBL204058 pe2r4_rat Rat No 7.7 IC50 = 22 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
396 12 2 4 3.6 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)Cl)O)CCCCCCC(=O)O
CHEMBL1669004 pe2r4_human Human No 7.7 IC50 = 22 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
693 10 2 6 6.9 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6Br)C
CHEMBL204058 pe2r4_rat Rat No 7.7 IC50 = 22 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
396 12 2 4 3.6 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)Cl)O)CCCCCCC(=O)O
CHEMBL1669004 pe2r4_human Human No 7.7 IC50 = 22 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
693 10 2 6 6.9 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6Br)C
CHEMBL381755 pe2r4_rat Rat No 6.7 IC50 = 220 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
488 12 2 5 5.3 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)OC3=CC=CC=C3)O)CCCC4=CC=C(C=C4)C(=O)O
CHEMBL381755 pe2r4_rat Rat No 6.7 IC50 = 220 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
488 12 2 5 5.3 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)OC3=CC=CC=C3)O)CCCC4=CC=C(C=C4)C(=O)O
CHEMBL1669009 pe2r4_human Human No 7.6 IC50 = 23 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
644 11 2 7 6.2 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6OC)C
CHEMBL1669009 pe2r4_human Human No 7.6 IC50 = 23 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
644 11 2 7 6.2 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6OC)C
CHEMBL1669017 pe2r4_human Human No 7.6 IC50 = 23.6 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
580 11 1 6 5.3 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=C(C=CC=N6)OC)C
CHEMBL1669017 pe2r4_human Human No 7.6 IC50 = 23.6 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
580 11 1 6 5.3 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=C(C=CC=N6)OC)C
CHEMBL1093792 pe2r4_human Human No 5.6 IC50 = 2300 Funct
Binding affinity to human EP4 receptor by radioligand displacement assayBinding affinity to human EP4 receptor by radioligand displacement assay
535 6 2 7 4.2 C1=CC=C2C=C(C=CC2=C1)CN3C(=O)C(C4=CC=CC(=C43)C=CC(=O)NS(=O)(=O)C5=CC(=C(C=C5)F)F)O
CHEMBL1093792 pe2r4_human Human No 5.6 IC50 = 2300 Funct
Binding affinity to human EP4 receptor by radioligand displacement assayBinding affinity to human EP4 receptor by radioligand displacement assay
535 6 2 7 4.2 C1=CC=C2C=C(C=CC2=C1)CN3C(=O)C(C4=CC=CC(=C43)C=CC(=O)NS(=O)(=O)C5=CC(=C(C=C5)F)F)O
CHEMBL400404 pe2r4_human Human No 4.6 IC50 = 24000 Funct
Inhibition of human recombinant EP4 receptor expressed in 293EBNA cellsInhibition of human recombinant EP4 receptor expressed in 293EBNA cells
484 9 3 6 4.3 CC(=O)NC1=CC=CC(=C1)C2=CC=C(C=C2)CC3=C(N=CO3)C(=O)NC(CC4=CC=CC=C4)C(=O)O
CHEMBL400404 pe2r4_human Human No 4.6 IC50 = 24000 Funct
Inhibition of human recombinant EP4 receptor expressed in 293EBNA cellsInhibition of human recombinant EP4 receptor expressed in 293EBNA cells
484 9 3 6 4.3 CC(=O)NC1=CC=CC(=C1)C2=CC=C(C=C2)CC3=C(N=CO3)C(=O)NC(CC4=CC=CC=C4)C(=O)O
CHEMBL3740325 pe2r4_human Human No 6.6 IC50 = 243 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
430 4 2 3 6.5 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)Cl
CHEMBL3740325 pe2r4_human Human No 6.6 IC50 = 243 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay
430 4 2 3 6.5 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)Cl
CHEMBL3740325 pe2r4_human Human No 6.6 IC50 = 243 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
430 4 2 3 6.5 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)Cl
CHEMBL3740325 pe2r4_human Human No 6.6 IC50 = 243 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay
430 4 2 3 6.5 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)Cl
CHEMBL553468 pe2r4_rat Rat No 5.6 IC50 = 2467 Funct
Inhibition of rat EP4 receptor expressed in HEK293 cellsInhibition of rat EP4 receptor expressed in HEK293 cells
370 11 1 5 3.8 CC(C)(C)C1=CC=C(C=C1)CN(CCCCCCC(=O)O)S(=O)(=O)C
CHEMBL553468 pe2r4_rat Rat No 5.6 IC50 = 2467 Funct
Inhibition of rat EP4 receptor expressed in HEK293 cellsInhibition of rat EP4 receptor expressed in HEK293 cells
370 11 1 5 3.8 CC(C)(C)C1=CC=C(C=C1)CN(CCCCCCC(=O)O)S(=O)(=O)C
CHEMBL427035 pe2r4_rat Rat No 6.6 IC50 = 250 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
395 10 2 4 3.7 C1CC(=O)N(C1CCC(CC2=CC=CC=C2)O)CCCC3=CC=C(C=C3)C(=O)O
CHEMBL427035 pe2r4_rat Rat No 6.6 IC50 = 250 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
395 10 2 4 3.7 C1CC(=O)N(C1CCC(CC2=CC=CC=C2)O)CCCC3=CC=C(C=C3)C(=O)O
CHEMBL551951 pe2r4_rat Rat Yes 5.6 IC50 = 2533 Funct
Inhibition of rat EP4 receptor expressed in HEK293 cellsInhibition of rat EP4 receptor expressed in HEK293 cells
366 16 2 6 3.1 CCCCCC(CCCN(CCCCCCC(=O)O)S(=O)(=O)C)O
CHEMBL551951 pe2r4_rat Rat Yes 5.6 IC50 = 2533 Funct
Inhibition of rat EP4 receptor expressed in HEK293 cellsInhibition of rat EP4 receptor expressed in HEK293 cells
366 16 2 6 3.1 CCCCCC(CCCN(CCCCCCC(=O)O)S(=O)(=O)C)O
CHEMBL1645146 pe2r4_human Human No 6.6 IC50 = 258 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
401 6 2 5 3.2 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CN=CC=C4
CHEMBL1645146 pe2r4_human Human No 6.6 IC50 = 258 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
401 6 2 5 3.2 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=CN=CC=C4
CHEMBL1537470 pe2r4_human Human Yes 5.6 IC50 = 2600 Funct
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation counting
305 4 2 3 4.0 C1=CC=C2C(=C1)C=CC=C2CC(=O)NC3=CC=CC=C3C(=O)O
CHEMBL1537470 pe2r4_human Human Yes 5.6 IC50 = 2600 Funct
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation counting
305 4 2 3 4.0 C1=CC=C2C(=C1)C=CC=C2CC(=O)NC3=CC=CC=C3C(=O)O
CHEMBL1910025 pe2r4_human Human No 7.6 IC50 = 27 Funct
Displacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cellsDisplacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cells
467 4 2 7 5.3 C1CC2=C(C=CC(=C2)C(F)(F)F)OC3=C(C=CC=C31)C(=O)NC4(CC4)C5=CC=C(C=C5)C(=O)O
CHEMBL1910025 pe2r4_human Human No 7.6 IC50 = 27 Funct
Displacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cellsDisplacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cells
467 4 2 7 5.3 C1CC2=C(C=CC(=C2)C(F)(F)F)OC3=C(C=CC=C31)C(=O)NC4(CC4)C5=CC=C(C=C5)C(=O)O
CHEMBL2113220 pe2r4_rat Rat No 5.6 IC50 = 2705 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
376 13 2 4 3.4 C1CC(=O)N(C1CCC(CCC2=CC=CC=C2)O)CCCCCCC(=O)O
CHEMBL2113220 pe2r4_rat Rat No 5.6 IC50 = 2705 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
376 13 2 4 3.4 C1CC(=O)N(C1CCC(CCC2=CC=CC=C2)O)CCCCCCC(=O)O
CHEMBL444798 pe2r4_rat Rat No 5.6 IC50 = 2767 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
413 10 2 5 3.8 C1CC(=O)N(C1CCC(CC2=CC=C(C=C2)F)O)CCCC3=CC=C(C=C3)C(=O)O
CHEMBL444798 pe2r4_rat Rat No 5.6 IC50 = 2767 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
413 10 2 5 3.8 C1CC(=O)N(C1CCC(CC2=CC=C(C=C2)F)O)CCCC3=CC=C(C=C3)C(=O)O
CHEMBL1669006 pe2r4_human Human No 7.6 IC50 = 28 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
682 10 2 9 7.1 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6C(F)(F)F)C
CHEMBL1669025 pe2r4_human Human No 7.6 IC50 = 28 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
683 10 2 6 7.5 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C(=CC=C6)Cl)Cl)C
CHEMBL1669006 pe2r4_human Human No 7.6 IC50 = 28 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
682 10 2 9 7.1 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6C(F)(F)F)C
CHEMBL1669025 pe2r4_human Human No 7.6 IC50 = 28 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
683 10 2 6 7.5 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C(=CC=C6)Cl)Cl)C
CHEMBL3793928 pe2r4_human Human No 5.5 IC50 = 2890 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
397 5 3 6 3.2 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)N3CCCC(C3)CO)C
CHEMBL3793928 pe2r4_human Human No 5.5 IC50 = 2890 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
397 5 3 6 3.2 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)N3CCCC(C3)CO)C
CHEMBL1669008 pe2r4_human Human No 8.5 IC50 = 3 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
683 10 2 6 7.5 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6Cl)Cl)C
CHEMBL1645154 pe2r4_human Human No 8.5 IC50 = 3 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
536 6 2 10 6.0 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CC(=CC3=C2N(CC3)CC4=CC=C(C=C4)C(F)(F)F)C(F)(F)F
CHEMBL1669011 pe2r4_human Human No 8.5 IC50 = 3 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
757 10 2 13 7.4 CC1=C(C=CC(=C1)CC2(CC2)NC(=O)NS(=O)(=O)C3=CC=CC=C3Cl)N4CC5=C(C6=C(C=CC=N6)C(=C5C4=O)OCC(F)(F)F)OCC(F)(F)F
CHEMBL1669008 pe2r4_human Human No 8.5 IC50 = 3 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
683 10 2 6 7.5 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6Cl)Cl)C
CHEMBL1669008 pe2r4_human Human No 8.5 IC50 = 3 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
683 10 2 6 7.5 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6Cl)Cl)C
CHEMBL1645154 pe2r4_human Human No 8.5 IC50 = 3 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
536 6 2 10 6.0 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CC(=CC3=C2N(CC3)CC4=CC=C(C=C4)C(F)(F)F)C(F)(F)F
CHEMBL1669011 pe2r4_human Human No 8.5 IC50 = 3 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
757 10 2 13 7.4 CC1=C(C=CC(=C1)CC2(CC2)NC(=O)NS(=O)(=O)C3=CC=CC=C3Cl)N4CC5=C(C6=C(C=CC=N6)C(=C5C4=O)OCC(F)(F)F)OCC(F)(F)F
CHEMBL1669008 pe2r4_human Human No 8.5 IC50 = 3 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
683 10 2 6 7.5 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6Cl)Cl)C
CHEMBL3739779 pe2r4_human Human No 8.5 IC50 = 3.1 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
426 5 3 5 4.1 CC1=CC(=CC(=C1NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC(=CC=C4)CO)C)C(=O)O
CHEMBL3739779 pe2r4_human Human No 8.5 IC50 = 3.1 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
426 5 3 5 4.1 CC1=CC(=CC(=C1NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC(=CC=C4)CO)C)C(=O)O
CHEMBL1669026 pe2r4_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
642 10 2 6 7.0 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6C)C)C
CHEMBL1669026 pe2r4_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
642 10 2 6 7.0 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6C)C)C
CHEMBL1085041 pe2r4_human Human No 8.5 IC50 = 3.3 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
451 6 2 4 5.0 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC(=C2)F)C=CN3CC4=CC(=CC=C4)Cl
CHEMBL1669005 pe2r4_human Human No 8.5 IC50 = 3.3 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
674 12 2 8 6.2 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6OC)OC)C
CHEMBL1669006 pe2r4_human Human No 8.5 IC50 = 3.3 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
682 10 2 9 7.1 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6C(F)(F)F)C
CHEMBL1669010 pe2r4_human Human No 8.5 IC50 = 3.3 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
628 10 2 6 6.6 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6C)C
CHEMBL1085041 pe2r4_human Human No 8.5 IC50 = 3.3 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
451 6 2 4 5.0 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC(=C2)F)C=CN3CC4=CC(=CC=C4)Cl
CHEMBL1669005 pe2r4_human Human No 8.5 IC50 = 3.3 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
674 12 2 8 6.2 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=C(C=CC=C6OC)OC)C
CHEMBL1669006 pe2r4_human Human No 8.5 IC50 = 3.3 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
682 10 2 9 7.1 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6C(F)(F)F)C
CHEMBL1669010 pe2r4_human Human No 8.5 IC50 = 3.3 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
628 10 2 6 6.6 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6C)C
CHEMBL3742015 pe2r4_human Human No 8.5 IC50 = 3.5 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
395 4 2 3 5.9 CC1=CC(=CC(=C1NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC=CC=C4)C)C(=O)O
CHEMBL3742015 pe2r4_human Human No 8.5 IC50 = 3.5 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
395 4 2 3 5.9 CC1=CC(=CC(=C1NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC=CC=C4)C)C(=O)O
CHEMBL1645152 pe2r4_human Human No 8.5 IC50 = 3.5 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
493 6 2 8 4.8 CC(C1=CC=C(C=C1)C2=NNN=N2)NC(=O)C3=C4C(=CC=C3)CCN4CC5=CC=C(C=C5)C(F)(F)F
CHEMBL1645152 pe2r4_human Human No 8.5 IC50 = 3.5 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
493 6 2 8 4.8 CC(C1=CC=C(C=C1)C2=NNN=N2)NC(=O)C3=C4C(=CC=C3)CCN4CC5=CC=C(C=C5)C(F)(F)F
CHEMBL599052 pe2r4_human Human No 8.4 IC50 = 3.6 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
469 6 2 4 6.8 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(SC(=C2CC3=CC(=CC=C3)Cl)Cl)Cl
CHEMBL599052 pe2r4_human Human No 8.4 IC50 = 3.6 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
469 6 2 4 6.8 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(SC(=C2CC3=CC(=CC=C3)Cl)Cl)Cl
CHEMBL3740325 pe2r4_human Human No 8.4 IC50 = 3.6 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
430 4 2 3 6.5 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)Cl
CHEMBL3740325 pe2r4_human Human No 8.4 IC50 = 3.6 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
430 4 2 3 6.5 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)Cl
CHEMBL3740325 pe2r4_human Human No 8.4 IC50 = 3.6 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
430 4 2 3 6.5 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)Cl
CHEMBL3740325 pe2r4_human Human No 8.4 IC50 = 3.6 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
430 4 2 3 6.5 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC(=CC=C4)Cl
CHEMBL1669016 pe2r4_human Human No 8.4 IC50 = 3.8 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
623 12 2 7 5.8 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=C(C=CC(=C6)C(=O)O)OC)C
CHEMBL1669009 pe2r4_human Human No 8.4 IC50 = 3.8 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
644 11 2 7 6.2 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6OC)C
CHEMBL548 pe2r4_human Human Yes 8.4 IC50 = 3.8 Funct
Displacement of radiolabeled PGE2 from human prostanoid EP4 receptorDisplacement of radiolabeled PGE2 from human prostanoid EP4 receptor
353 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL1669016 pe2r4_human Human No 8.4 IC50 = 3.8 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
623 12 2 7 5.8 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=C(C=CC(=C6)C(=O)O)OC)C
CHEMBL1669009 pe2r4_human Human No 8.4 IC50 = 3.8 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
644 11 2 7 6.2 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6OC)C
CHEMBL548 pe2r4_human Human Yes 8.4 IC50 = 3.8 Funct
Displacement of radiolabeled PGE2 from human prostanoid EP4 receptorDisplacement of radiolabeled PGE2 from human prostanoid EP4 receptor
353 12 3 5 2.8 CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
CHEMBL3586361 pe2r4_human Human No 4.5 IC50 = 30000 Funct
Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay
437 3 1 4 4.5 CC1COC2=C(CN1CC3=CC(=O)NC=C3)C=C(C=C2Cl)C4=CSC5=CC=CC=C54
CHEMBL3586360 pe2r4_human Human No 4.5 IC50 = 30000 Funct
Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay
424 3 1 4 3.3 C1COC2=C(C=C(C=C2CN1CC3=CC(=O)NC=C3)N4C=CC5=C4C=CC(=C5)F)Cl
CHEMBL3586361 pe2r4_human Human No 4.5 IC50 = 30000 Funct
Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay
437 3 1 4 4.5 CC1COC2=C(CN1CC3=CC(=O)NC=C3)C=C(C=C2Cl)C4=CSC5=CC=CC=C54
CHEMBL3586360 pe2r4_human Human No 4.5 IC50 = 30000 Funct
Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay
424 3 1 4 3.3 C1COC2=C(C=C(C=C2CN1CC3=CC(=O)NC=C3)N4C=CC5=C4C=CC(=C5)F)Cl
CHEMBL3741902 pe2r4_human Human No 6.5 IC50 = 312 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay
426 5 3 5 4.1 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC(=CC=C4)CO
CHEMBL3741902 pe2r4_human Human No 6.5 IC50 = 312 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay
426 5 3 5 4.1 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC(=CC=C4)CO
CHEMBL3586353 pe2r4_human Human No 5.5 IC50 = 3200 Funct
Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay
407 3 0 4 5.2 C1COC2=C(CN1CC3=CN=CC=C3)C=C(C=C2Cl)C4=CSC5=CC=CC=C54
CHEMBL3586353 pe2r4_human Human No 5.5 IC50 = 3200 Funct
Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay
407 3 0 4 5.2 C1COC2=C(CN1CC3=CN=CC=C3)C=C(C=C2Cl)C4=CSC5=CC=CC=C54
CHEMBL1669012 pe2r4_human Human No 7.5 IC50 = 33 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
648 10 2 6 6.9 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6Cl)C
CHEMBL1669012 pe2r4_human Human No 7.5 IC50 = 33 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
648 10 2 6 6.9 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6Cl)C
CHEMBL208399 pe2r4_rat Rat No 6.5 IC50 = 337 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
438 13 2 4 4.6 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCCCCCC(=O)O
CHEMBL208399 pe2r4_rat Rat No 6.5 IC50 = 337 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
438 13 2 4 4.6 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCCCCCC(=O)O
CHEMBL1910025 pe2r4_human Human No 7.5 IC50 = 34 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assay
467 4 2 7 5.3 C1CC2=C(C=CC(=C2)C(F)(F)F)OC3=C(C=CC=C31)C(=O)NC4(CC4)C5=CC=C(C=C5)C(=O)O
CHEMBL1910025 pe2r4_human Human No 7.5 IC50 = 34 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assay
467 4 2 7 5.3 C1CC2=C(C=CC(=C2)C(F)(F)F)OC3=C(C=CC=C31)C(=O)NC4(CC4)C5=CC=C(C=C5)C(=O)O
CHEMBL1669015 pe2r4_human Human No 7.5 IC50 = 35.1 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
583 10 1 4 7.0 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=CC=CC=C6Cl)C
CHEMBL1669015 pe2r4_human Human No 7.5 IC50 = 35.1 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
583 10 1 4 7.0 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=CC=CC=C6Cl)C
CHEMBL3586309 pe2r4_human Human No 5.5 IC50 = 3500 Funct
Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay
403 4 0 5 4.5 COC1=CC(=CC2=C1OCCN(C2)CC3=CN=CC=C3)C4=CSC5=CC=CC=C54
CHEMBL3586309 pe2r4_human Human No 5.5 IC50 = 3500 Funct
Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay
403 4 0 5 4.5 COC1=CC(=CC2=C1OCCN(C2)CC3=CN=CC=C3)C4=CSC5=CC=CC=C54
CHEMBL3793924 pe2r4_human Human No 5.4 IC50 = 3600 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
397 4 3 6 3.2 CC1=C(N=C(C=C1)N2CCC(CC2)(C)O)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3793924 pe2r4_human Human No 5.4 IC50 = 3600 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
397 4 3 6 3.2 CC1=C(N=C(C=C1)N2CCC(CC2)(C)O)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL565799 pe2r4_human Human No 5.4 IC50 = 3647 Funct
Displacement of [3H]PGE2 from human EP4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor after 1 hr by liquid scintillation counting
573 6 1 5 7.7 CC1=CN(C2=C(C=C(C=C12)F)C=CC(=O)NS(=O)(=O)C3=CC(=C(S3)Cl)Cl)CC4=CC5=CC=CC=C5C=C4
CHEMBL565799 pe2r4_human Human No 5.4 IC50 = 3647 Funct
Displacement of [3H]PGE2 from human EP4 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor after 1 hr by liquid scintillation counting
573 6 1 5 7.7 CC1=CN(C2=C(C=C(C=C12)F)C=CC(=O)NS(=O)(=O)C3=CC(=C(S3)Cl)Cl)CC4=CC5=CC=CC=C5C=C4
CHEMBL1669007 pe2r4_human Human No 7.4 IC50 = 37 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
664 10 2 6 7.5 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC7=CC=CC=C7C=C6)C
CHEMBL1669007 pe2r4_human Human No 7.4 IC50 = 37 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
664 10 2 6 7.5 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC7=CC=CC=C7C=C6)C
CHEMBL1669002 pe2r4_human Human No 6.4 IC50 = 370 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
698 11 2 10 7.4 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=C(C=C6)OC(F)(F)F)C
CHEMBL1669002 pe2r4_human Human No 6.4 IC50 = 370 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
698 11 2 10 7.4 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=C(C=C6)OC(F)(F)F)C
CHEMBL461571 pe2r4_human Human No 5.4 IC50 = 3700 Funct
Inhibition of prostanoid EP4 receptorInhibition of prostanoid EP4 receptor
532 8 1 8 7.1 CC1=C(C2=C(N1CC3=CC(=CC=C3)OC(C)C(=O)O)C=C(C=C2)OC(F)(F)F)C(=O)C4=CC=C(C=C4)Cl
CHEMBL461571 pe2r4_human Human No 5.4 IC50 = 3700 Funct
Inhibition of prostanoid EP4 receptorInhibition of prostanoid EP4 receptor
532 8 1 8 7.1 CC1=C(C2=C(N1CC3=CC(=CC=C3)OC(C)C(=O)O)C=C(C=C2)OC(F)(F)F)C(=O)C4=CC=C(C=C4)Cl
CHEMBL591666 pe2r4_human Human Yes 7.4 IC50 = 38.2 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP level by HTS assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP level by HTS assay
414 6 2 5 4.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(C=CC(=C2)Cl)OC3=CC=C(C=C3)F
CHEMBL3754085 pe2r4_human Human Yes 7.4 IC50 = 38.7 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
390 5 3 5 3.4 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C
CHEMBL3754085 pe2r4_human Human Yes 7.4 IC50 = 38.7 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
390 5 3 5 3.4 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C
CHEMBL3754085 pe2r4_human Human Yes 7.4 IC50 = 38.7 Funct
Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassayAntagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubated for 30 mins followed by LPS stimulation measured after 20 to 24 hrs by enzyme immunoassay
390 5 3 5 3.4 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C
CHEMBL3754085 pe2r4_human Human Yes 7.4 IC50 = 38.7 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
390 5 3 5 3.4 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C
CHEMBL425409 pe2r4_rat Rat No 6.4 IC50 = 388 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
386 12 2 5 2.7 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C#N)O)CCCCCCC(=O)O
CHEMBL425409 pe2r4_rat Rat No 6.4 IC50 = 388 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
386 12 2 5 2.7 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C#N)O)CCCCCCC(=O)O
CHEMBL3793924 pe2r4_human Human No 7.4 IC50 = 39.8 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
397 4 3 6 3.2 CC1=C(N=C(C=C1)N2CCC(CC2)(C)O)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3793924 pe2r4_human Human No 7.4 IC50 = 39.8 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
397 4 3 6 3.2 CC1=C(N=C(C=C1)N2CCC(CC2)(C)O)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL1910023 pe2r4_human Human No 8.4 IC50 = 4 Funct
Displacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cellsDisplacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cells
467 4 2 7 5.3 C1CC2=CC=CC(=C2OC3=C1C=CC(=C3)C(F)(F)F)C(=O)NC4(CC4)C5=CC=C(C=C5)C(=O)O
CHEMBL1910023 pe2r4_human Human No 8.4 IC50 = 4 Funct
Displacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cellsDisplacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cells
467 4 2 7 5.3 C1CC2=CC=CC(=C2OC3=C1C=CC(=C3)C(F)(F)F)C(=O)NC4(CC4)C5=CC=C(C=C5)C(=O)O
CHEMBL3753133 pe2r4_human Human No 8.4 IC50 = 4.5 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
393 5 3 5 3.9 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=C2)C3=CC(=CC=C3)CO)F
CHEMBL3753133 pe2r4_human Human No 8.4 IC50 = 4.5 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
393 5 3 5 3.9 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=C2)C3=CC(=CC=C3)CO)F
CHEMBL603690 pe2r4_human Human No 8.4 IC50 = 4.5 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
461 6 2 7 5.9 CC1=C(C(=C(S1)C)C(=O)NC(C)C2=CC=C(C=C2)C(=O)O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL603690 pe2r4_human Human No 8.4 IC50 = 4.5 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
461 6 2 7 5.9 CC1=C(C(=C(S1)C)C(=O)NC(C)C2=CC=C(C=C2)C(=O)O)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL1669024 pe2r4_human Human No 8.3 IC50 = 4.6 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
632 10 2 7 6.4 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=C(C=C6)F)C
CHEMBL1669018 pe2r4_human Human No 8.3 IC50 = 4.6 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
579 11 1 5 6.3 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=CC=CC=C6OC)C
CHEMBL1669024 pe2r4_human Human No 8.3 IC50 = 4.6 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
632 10 2 7 6.4 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=C(C=C6)F)C
CHEMBL1669018 pe2r4_human Human No 8.3 IC50 = 4.6 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
579 11 1 5 6.3 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=CC=CC=C6OC)C
CHEMBL605330 pe2r4_human Human No 8.3 IC50 = 4.7 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
461 6 2 7 5.9 CC1=C(C(=C(S1)C)C(=O)NC(C)C2=CC=C(C=C2)C(=O)O)CC3=CC(=CC=C3)C(F)(F)F
CHEMBL1645149 pe2r4_human Human No 8.3 IC50 = 4.7 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
547 6 2 7 5.8 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=C(C=C(C=C4)C(F)(F)F)Br
CHEMBL605330 pe2r4_human Human No 8.3 IC50 = 4.7 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
461 6 2 7 5.9 CC1=C(C(=C(S1)C)C(=O)NC(C)C2=CC=C(C=C2)C(=O)O)CC3=CC(=CC=C3)C(F)(F)F
CHEMBL1645149 pe2r4_human Human No 8.3 IC50 = 4.7 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
547 6 2 7 5.8 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCN3CC4=C(C=C(C=C4)C(F)(F)F)Br
CHEMBL1669017 pe2r4_human Human No 8.3 IC50 = 4.9 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
580 11 1 6 5.3 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=C(C=CC=N6)OC)C
CHEMBL1669017 pe2r4_human Human No 8.3 IC50 = 4.9 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
580 11 1 6 5.3 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)CC6=C(C=CC=N6)OC)C
CHEMBL1910024 pe2r4_human Human No 7.4 IC50 = 42 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assay
455 4 2 7 5.3 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCC4=C(O3)C=CC(=C4)C(F)(F)F
CHEMBL383515 pe2r4_rat Rat No 7.4 IC50 = 42 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
430 10 2 4 4.4 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)Cl)O)CCCC3=CC=C(C=C3)C(=O)O
CHEMBL1910024 pe2r4_human Human No 7.4 IC50 = 42 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity assay
455 4 2 7 5.3 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C3C(=CC=C2)CCC4=C(O3)C=CC(=C4)C(F)(F)F
CHEMBL383515 pe2r4_rat Rat No 7.4 IC50 = 42 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
430 10 2 4 4.4 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)Cl)O)CCCC3=CC=C(C=C3)C(=O)O
CHEMBL815 pe2r4_human Human Yes 5.4 IC50 = 4200 Funct
Affinity for Prostanoid EP4 receptor expressed in CHO cellsAffinity for Prostanoid EP4 receptor expressed in CHO cells
355 12 4 5 2.7 CCCCCC(C=CC1C(CC(C1CC=CCCCC(=O)O)O)O)O
CHEMBL815 pe2r4_human Human Yes 5.4 IC50 = 4200 Funct
In vitro binding at EP4 human prostaglandin receptor using [3H]PGE-2 as radioligandIn vitro binding at EP4 human prostaglandin receptor using [3H]PGE-2 as radioligand
355 12 4 5 2.7 CCCCCC(C=CC1C(CC(C1CC=CCCCC(=O)O)O)O)O
CHEMBL1669012 pe2r4_human Human No 6.4 IC50 = 423 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 releaseAntagonist activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 release
648 10 2 6 6.9 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6Cl)C
CHEMBL1669012 pe2r4_human Human No 6.4 IC50 = 423 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 releaseAntagonist activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNF-alpha-induced IP10 release
648 10 2 6 6.9 CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=C(C=C(C=C4)CC5(CC5)NC(=O)NS(=O)(=O)C6=CC=CC=C6Cl)C
CHEMBL3260421 pe2r4_human Human Yes 6.3 IC50 = 460 Funct
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation counting
357 2 1 5 3.7 C1=CC=C2C(=C1)C3=C(O2)C=C(C=C3)N4C(=O)C5=C(C4=O)C=C(C=C5)C(=O)O
CHEMBL3260421 pe2r4_human Human Yes 6.3 IC50 = 460 Funct
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation counting
357 2 1 5 3.7 C1=CC=C2C(=C1)C3=C(O2)C=C(C=C3)N4C(=O)C5=C(C4=O)C=C(C=C5)C(=O)O
CHEMBL3260423 pe2r4_human Human Yes 5.3 IC50 = 4600 Funct
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation counting
322 4 1 5 4.5 CC1=C(C=C(O1)C(=O)O)COC2=CC3=C(C=C2)OC4=CC=CC=C43
CHEMBL3260423 pe2r4_human Human Yes 5.3 IC50 = 4600 Funct
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation counting
322 4 1 5 4.5 CC1=C(C=C(O1)C(=O)O)COC2=CC3=C(C=C2)OC4=CC=CC=C43
CHEMBL208411 pe2r4_rat Rat No 7.3 IC50 = 47 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
472 11 2 4 5.4 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCCC4=CC=C(C=C4)C(=O)O
CHEMBL208411 pe2r4_rat Rat No 7.3 IC50 = 47 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
472 11 2 4 5.4 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCCC4=CC=C(C=C4)C(=O)O
CHEMBL3753567 pe2r4_human Human No 7.3 IC50 = 47.8 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
393 5 3 5 3.9 CC1=CC(=CC(=C1NC(=O)C2=C(C=CC(=C2)C3=CC(=CC=C3)CO)F)C)C(=O)O
CHEMBL3753567 pe2r4_human Human No 7.3 IC50 = 47.8 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
393 5 3 5 3.9 CC1=CC(=CC(=C1NC(=O)C2=C(C=CC(=C2)C3=CC(=CC=C3)CO)F)C)C(=O)O
CHEMBL1669011 pe2r4_human Human No 7.3 IC50 = 48 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
757 10 2 13 7.4 CC1=C(C=CC(=C1)CC2(CC2)NC(=O)NS(=O)(=O)C3=CC=CC=C3Cl)N4CC5=C(C6=C(C=CC=N6)C(=C5C4=O)OCC(F)(F)F)OCC(F)(F)F
CHEMBL1669011 pe2r4_human Human No 7.3 IC50 = 48 Funct
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumDisplacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
757 10 2 13 7.4 CC1=C(C=CC(=C1)CC2(CC2)NC(=O)NS(=O)(=O)C3=CC=CC=C3Cl)N4CC5=C(C6=C(C=CC=N6)C(=C5C4=O)OCC(F)(F)F)OCC(F)(F)F
CHEMBL3741902 pe2r4_human Human No 8.3 IC50 = 5.2 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
426 5 3 5 4.1 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC(=CC=C4)CO
CHEMBL3741902 pe2r4_human Human No 8.3 IC50 = 5.2 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
426 5 3 5 4.1 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC(=CC=C4)CO
CHEMBL599262 pe2r4_human Human No 8.3 IC50 = 5.4 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
428 6 2 4 5.7 CC1=C(C(=C(S1)C)C(=O)NC(C)C2=CC=C(C=C2)C(=O)O)CC3=CC=C(C=C3)Cl
CHEMBL599262 pe2r4_human Human No 8.3 IC50 = 5.4 Funct
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
428 6 2 4 5.7 CC1=C(C(=C(S1)C)C(=O)NC(C)C2=CC=C(C=C2)C(=O)O)CC3=CC=C(C=C3)Cl
CHEMBL3686863 pe2r4_human Human No 8.3 IC50 = 5.6 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
383 4 3 6 3.0 CC1=C(N=C(C=C1)N2CCC(CC2)O)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3686863 pe2r4_human Human No 8.3 IC50 = 5.6 Funct
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assayAntagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by HTRF assay
383 4 3 6 3.0 CC1=C(N=C(C=C1)N2CCC(CC2)O)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3739435 pe2r4_human Human No 8.3 IC50 = 5.7 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
395 4 2 3 5.9 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC=CC=C4
CHEMBL3739435 pe2r4_human Human No 8.3 IC50 = 5.7 Funct
Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationAntagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation
395 4 2 3 5.9 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC=CC=C4
CHEMBL1645148 pe2r4_human Human No 8.2 IC50 = 5.8 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
415 6 2 4 4.6 CC1=CC=C(C=C1)CN2CCC3=CC=CC(=C32)C(=O)NC(C)C4=CC=C(C=C4)C(=O)O
CHEMBL1645148 pe2r4_human Human No 8.2 IC50 = 5.8 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
415 6 2 4 4.6 CC1=CC=C(C=C1)CN2CCC3=CC=CC(=C32)C(=O)NC(C)C4=CC=C(C=C4)C(=O)O
CHEMBL1085081 pe2r4_human Human No 8.2 IC50 = 5.9 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
433 6 2 3 4.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CC=CC3=C2N(C=C3)CC4=CC(=CC=C4)Cl
CHEMBL1085081 pe2r4_human Human No 8.2 IC50 = 5.9 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
433 6 2 3 4.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CC=CC3=C2N(C=C3)CC4=CC(=CC=C4)Cl
CHEMBL382197 pe2r4_rat Rat No 7.3 IC50 = 50 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
478 11 2 5 5.4 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCCC4=CC=C(S4)C(=O)O
CHEMBL382197 pe2r4_rat Rat No 7.3 IC50 = 50 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
478 11 2 5 5.4 C1CC(=O)N(C1CCC(CC2=CC=CC(=C2)C3=CC=CC=C3)O)CCCC4=CC=C(S4)C(=O)O
CHEMBL3739779 pe2r4_human Human No 6.3 IC50 = 501 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay
426 5 3 5 4.1 CC1=CC(=CC(=C1NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC(=CC=C4)CO)C)C(=O)O
CHEMBL3739779 pe2r4_human Human No 6.3 IC50 = 501 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay
426 5 3 5 4.1 CC1=CC(=CC(=C1NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC(=CC=C4)CO)C)C(=O)O
CHEMBL206774 pe2r4_rat Rat No 6.3 IC50 = 536 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
454 14 2 5 4.5 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)OC3=CC=CC=C3)O)CCCCCCC(=O)O
CHEMBL206774 pe2r4_rat Rat No 6.3 IC50 = 536 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
454 14 2 5 4.5 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)OC3=CC=CC=C3)O)CCCCCCC(=O)O
CHEMBL203780 pe2r4_rat Rat No 7.3 IC50 = 54 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
361 12 2 4 3.0 C1CC(=O)N(C1CCC(CC2=CC=CC=C2)O)CCCCCCC(=O)O
CHEMBL203780 pe2r4_rat Rat No 7.3 IC50 = 54 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
361 12 2 4 3.0 C1CC(=O)N(C1CCC(CC2=CC=CC=C2)O)CCCCCCC(=O)O
CHEMBL3753835 pe2r4_human Human No 7.3 IC50 = 56.3 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
390 5 3 5 3.4 CC1=C(N=C(C=C1)C2=CC(=CC=C2)CO)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3753835 pe2r4_human Human No 7.3 IC50 = 56.3 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
390 5 3 5 3.4 CC1=C(N=C(C=C1)C2=CC(=CC=C2)CO)C(=O)NC3=C(C=C(C=C3C)C(=O)O)C
CHEMBL3739435 pe2r4_human Human No 6.2 IC50 = 577 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay
395 4 2 3 5.9 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC=CC=C4
CHEMBL3739435 pe2r4_human Human No 6.2 IC50 = 577 Funct
Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretreated for 30 mins using 3,3',5,5' tetramethylbiphenyl-4,4'-diamine substrate measured after 20 to 24 hrs by immunoassay
395 4 2 3 5.9 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=CC(=CC3=CC=CC=C32)C4=CC=CC=C4
CHEMBL3753286 pe2r4_human Human No 7.2 IC50 = 59 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
444 5 3 8 3.9 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C(F)(F)F
CHEMBL208510 pe2r4_rat Rat No 7.2 IC50 = 59 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
445 13 2 8 4.2 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)OC(F)(F)F)O)CCCCCCC(=O)O
CHEMBL3753286 pe2r4_human Human No 7.2 IC50 = 59 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
444 5 3 8 3.9 CC1=C(C(=C(C=C1)C(=O)O)C)NC(=O)C2=C(C=CC(=N2)C3=CC(=CC=C3)CO)C(F)(F)F
CHEMBL208510 pe2r4_rat Rat No 7.2 IC50 = 59 Funct
Binding affinity to rat EP4 receptor expressed in HEK293 cellsBinding affinity to rat EP4 receptor expressed in HEK293 cells
445 13 2 8 4.2 C1CC(=O)N(C1CCC(CC2=CC(=CC=C2)OC(F)(F)F)O)CCCCCCC(=O)O
CHEMBL3753274 pe2r4_human Human No 7.2 IC50 = 59.5 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
389 5 3 4 4.1 CC1=C(C=C(C=C1)C2=CC(=CC=C2)CO)C(=O)NC3=C(C=CC(=C3C)C(=O)O)C
CHEMBL3753274 pe2r4_human Human No 7.2 IC50 = 59.5 Funct
Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassayAntagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mins followed by addition of PGE2 measured after 20 to 24 hrs by immunoassay
389 5 3 4 4.1 CC1=C(C=C(C=C1)C2=CC(=CC=C2)CO)C(=O)NC3=C(C=CC(=C3C)C(=O)O)C
CHEMBL1085081 pe2r4_human Human No 8.2 IC50 = 6 Funct
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assayAntagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximity assay
433 6 2 3 4.9 CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=CC=CC3=C2N(C=C3)CC4=CC(=CC=C4)Cl