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Ligand source activities (1 row/activity)
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
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Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
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Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
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Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
| CHEMBL1322660 | 22191 | None | 5 | Human | Functional | EC50 | = | 3019.95 | 5.52 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 421.0 | 5 | 2 | 4 | 4.44 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccn2)cc1)c1ccc(Cl)cc1Cl | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4850296 | 184816 | None | 0 | Human | Functional | EC50 | = | 1258.93 | 5.90 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 454.0 | 5 | 2 | 3 | 5.70 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2Cl)cc1)c1ccc(Cl)cc1Cl | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4850346 | 184820 | None | 0 | Human | Functional | EC50 | = | 478.63 | 6.32 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 448.0 | 5 | 2 | 3 | 4.64 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1)c1ccc(Br)cc1F | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4852817 | 184991 | None | 0 | Human | Functional | EC50 | = | 2570.40 | 5.59 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 434.0 | 5 | 1 | 3 | 5.07 | CN(c1ccccc1)S(=O)(=O)c1ccc(NC(=O)c2ccc(Cl)cc2Cl)cc1 | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4852965 | 185000 | None | 6 | Human | Functional | EC50 | = | 457.09 | 6.34 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 420.0 | 5 | 2 | 3 | 5.05 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1)c1ccc(Cl)cc1Cl | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4852965 | 185000 | None | 6 | Human | Functional | EC50 | = | 912.00 | 6.04 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells assessed as induction of beta-arrestin recruitment pretreated with substrate for 45 mins followed by compound addition and measured for 40 mins by NanoLuc luciferase complementation assay | ChEMBL | 420.0 | 5 | 2 | 3 | 5.05 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1)c1ccc(Cl)cc1Cl | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4852965 | 185000 | None | 6 | Human | Functional | EC50 | = | 6606.93 | 5.18 | - | 1 | Agonist activity at CLuc-tagged human GPR27 expressed in HEK293 cells incubated for 10 mins by beta-arrestin 2 recruitment based firefly luciferase complementation assay | ChEMBL | 420.0 | 5 | 2 | 3 | 5.05 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1)c1ccc(Cl)cc1Cl | https://dx.doi.org/10.1021/acs.jmedchem.3c02030 | |
| CHEMBL4854273 | 185089 | None | 0 | Human | Functional | EC50 | = | 1023.29 | 5.99 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 460.0 | 6 | 2 | 4 | 4.51 | COc1cc(Br)ccc1C(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1 | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4857582 | 185306 | None | 0 | Human | Functional | EC50 | = | 851.14 | 6.07 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 444.0 | 5 | 2 | 3 | 4.81 | Cc1cc(Br)ccc1C(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1 | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4860248 | 185464 | None | 0 | Human | Functional | EC50 | = | 5128.61 | 5.29 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 496.0 | 5 | 2 | 3 | 4.48 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1)c1ccc(I)cc1F | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4861825 | 185567 | None | 0 | Human | Functional | EC50 | = | 229.09 | 6.64 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 395.1 | 5 | 2 | 4 | 3.75 | N#Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)Nc3ccccc3)cc2)c(F)c1 | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4865504 | 185808 | None | 0 | Human | Functional | EC50 | = | 1023.29 | 5.99 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 464.0 | 5 | 2 | 3 | 5.16 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1)c1ccc(Cl)cc1Br | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4866235 | 185855 | None | 6 | Human | Functional | EC50 | = | 1230.27 | 5.91 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 434.0 | 5 | 2 | 3 | 5.36 | Cc1ccccc1NS(=O)(=O)c1ccc(NC(=O)c2ccc(Cl)cc2Cl)cc1 | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4868057 | 185977 | None | 0 | Human | Functional | EC50 | = | 2290.87 | 5.64 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 405.0 | 5 | 2 | 4 | 3.93 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1)c1ccc(Cl)nc1F | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4868300 | 185991 | None | 0 | Human | Functional | EC50 | = | 3981.07 | 5.40 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 404.0 | 5 | 2 | 3 | 4.53 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1)c1ccc(Cl)cc1F | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4869253 | 186041 | None | 0 | Human | Functional | EC50 | = | 141.25 | 6.85 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 422.0 | 5 | 2 | 3 | 4.67 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1)c1cc(F)c(Cl)cc1F | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4869637 | 186069 | None | 11 | Human | Functional | EC50 | = | 1300.00 | 5.89 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells assessed as induction of beta-arrestin recruitment pretreated with substrate for 45 mins followed by compound addition and measured for 40 mins by NanoLuc luciferase complementation assay | ChEMBL | 427.0 | 5 | 2 | 5 | 4.50 | O=C(Nc1ccc(S(=O)(=O)Nc2nccs2)cc1)c1ccc(Cl)cc1Cl | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4869721 | 186080 | None | 0 | Human | Functional | EC50 | = | 575.44 | 6.24 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 454.0 | 5 | 2 | 3 | 5.70 | O=C(Nc1ccc(S(=O)(=O)Nc2cccc(Cl)c2)cc1)c1ccc(Cl)cc1Cl | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4871933 | 186236 | None | 1 | Human | Functional | EC50 | = | 7762.47 | 5.11 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 420.1 | 5 | 2 | 5 | 3.85 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1)c1cc2ccccc2oc1=O | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
| CHEMBL4872926 | 186302 | None | 0 | Human | Functional | EC50 | = | 5754.40 | 5.24 | - | 1 | Agonist activity at human GPR27 expressed in HEK293 cells co-expressing FnLArrb2.GPR27V2LFc assessed as induction of beta-arrestin recruitment incubated for 10 mins measured followed by addition of D-luciferin by firefly-luciferase complementation assay | ChEMBL | 421.0 | 5 | 2 | 4 | 4.44 | O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1)c1ncc(Cl)cc1Cl | https://dx.doi.org/10.1016/j.ejmech.2021.113777 | |
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