Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 122653602 | 184933 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 504 | 8 | 2 | 6 | 3.7 | COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)cc1F | nan | ||
| CHEMBL4852000 | 184933 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 504 | 8 | 2 | 6 | 3.7 | COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)cc1F | nan | ||
| 122653721 | 184504 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 377 | 5 | 1 | 4 | 3.6 | COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F | nan | ||
| CHEMBL4845846 | 184504 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 377 | 5 | 1 | 4 | 3.6 | COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F | nan | ||
| 122653713 | 184539 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 442 | 6 | 2 | 5 | 3.5 | O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1 | nan | ||
| CHEMBL4846330 | 184539 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 442 | 6 | 2 | 5 | 3.5 | O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1 | nan | ||
| 122653650 | 184540 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 393 | 5 | 1 | 4 | 4.1 | COc1cc(Cl)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1 | nan | ||
| CHEMBL4846333 | 184540 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 393 | 5 | 1 | 4 | 4.1 | COc1cc(Cl)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1 | nan | ||
| 122653704 | 184544 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 409 | 6 | 2 | 4 | 3.4 | O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1 | nan | ||
| CHEMBL4846416 | 184544 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 409 | 6 | 2 | 4 | 3.4 | O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1 | nan | ||
| 122653665 | 184558 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 510 | 7 | 2 | 5 | 4.0 | O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1 | nan | ||
| CHEMBL4846586 | 184558 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 510 | 7 | 2 | 5 | 4.0 | O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1 | nan | ||
| 122653719 | 184568 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 398 | 4 | 1 | 4 | 3.9 | NC(=O)c1cccc2c1CCN2c1cc(Cc2ccnc(C(F)(F)F)c2)ccn1 | nan | ||
| CHEMBL4846775 | 184568 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 398 | 4 | 1 | 4 | 3.9 | NC(=O)c1cccc2c1CCN2c1cc(Cc2ccnc(C(F)(F)F)c2)ccn1 | nan | ||
| 122653649 | 184574 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 397 | 4 | 1 | 3 | 4.5 | NC(=O)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1 | nan | ||
| CHEMBL4846914 | 184574 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 397 | 4 | 1 | 3 | 4.5 | NC(=O)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1 | nan | ||
| 122653642 | 184582 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 471 | 8 | 2 | 5 | 3.5 | COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1 | nan | ||
| CHEMBL4846977 | 184582 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 471 | 8 | 2 | 5 | 3.5 | COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1 | nan | ||
| 122653806 | 184627 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 486 | 7 | 1 | 4 | 4.8 | CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1 | nan | ||
| CHEMBL4847685 | 184627 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 486 | 7 | 1 | 4 | 4.8 | CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1 | nan | ||
| 122653408 | 184629 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 475 | 7 | 3 | 5 | 3.0 | O=C(NC[C@@H](O)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1 | nan | ||
| CHEMBL4847708 | 184629 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 475 | 7 | 3 | 5 | 3.0 | O=C(NC[C@@H](O)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1 | nan | ||
| 122653470 | 184633 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 504 | 7 | 2 | 5 | 4.6 | O=C(NC[C@@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1 | nan | ||
| CHEMBL4847735 | 184633 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 504 | 7 | 2 | 5 | 4.6 | O=C(NC[C@@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1 | nan | ||
| 122653679 | 184666 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 365 | 4 | 1 | 5 | 2.9 | NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(Cl)nc2)ccn1 | nan | ||
| CHEMBL4848378 | 184666 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 365 | 4 | 1 | 5 | 2.9 | NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(Cl)nc2)ccn1 | nan | ||
| 122653688 | 184667 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 381 | 4 | 1 | 3 | 4.3 | NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1 | nan | ||
| CHEMBL4848379 | 184667 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 381 | 4 | 1 | 3 | 4.3 | NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1 | nan | ||
| 122653654 | 184686 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 436 | 5 | 1 | 4 | 4.6 | N#CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1 | nan | ||
| CHEMBL4848606 | 184686 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 436 | 5 | 1 | 4 | 4.6 | N#CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1 | nan | ||
| 122653571 | 184695 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 365 | 4 | 1 | 3 | 3.7 | NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1 | nan | ||
| CHEMBL4848812 | 184695 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 365 | 4 | 1 | 3 | 3.7 | NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1 | nan | ||
| 122653464 | 184718 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 457 | 7 | 2 | 4 | 4.2 | O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1 | nan | ||
| CHEMBL4849056 | 184718 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 457 | 7 | 2 | 4 | 4.2 | O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1 | nan | ||
| 122653683 | 184731 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 465 | 9 | 2 | 6 | 3.3 | COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(OC)c(F)c2)ccn1 | nan | ||
| CHEMBL4849398 | 184731 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 465 | 9 | 2 | 6 | 3.3 | COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(OC)c(F)c2)ccn1 | nan | ||
| 122653417 | 184756 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 471 | 8 | 2 | 5 | 3.5 | COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1 | nan | ||
| CHEMBL4849645 | 184756 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 471 | 8 | 2 | 5 | 3.5 | COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1 | nan | ||
| 122653491 | 184761 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 368 | 4 | 2 | 3 | 3.9 | NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3[nH]ccc23)ccn1 | nan | ||
| CHEMBL4849698 | 184761 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 368 | 4 | 2 | 3 | 3.9 | NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3[nH]ccc23)ccn1 | nan | ||
| 122653696 | 184780 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 427 | 5 | 1 | 4 | 4.5 | COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C(F)(F)F | nan | ||
| CHEMBL4849904 | 184780 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 427 | 5 | 1 | 4 | 4.5 | COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C(F)(F)F | nan | ||
| 122653579 | 184785 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 459 | 7 | 2 | 4 | 3.8 | O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1 | nan | ||
| CHEMBL4849970 | 184785 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 459 | 7 | 2 | 4 | 3.8 | O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1 | nan | ||
| 122653601 | 184794 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 459 | 6 | 2 | 4 | 4.2 | O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1 | nan | ||
| CHEMBL4850054 | 184794 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 459 | 6 | 2 | 4 | 4.2 | O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1 | nan | ||
| 122653613 | 184832 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 455 | 6 | 2 | 4 | 4.4 | Cc1c(Cc2cccc(C(F)(F)F)c2)ccnc1N1CCc2c(C(=O)NCCO)cccc21 | nan | ||
| CHEMBL4850541 | 184832 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 455 | 6 | 2 | 4 | 4.4 | Cc1c(Cc2cccc(C(F)(F)F)c2)ccnc1N1CCc2c(C(=O)NCCO)cccc21 | nan | ||
| 122653676 | 184851 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 398 | 4 | 1 | 4 | 3.9 | NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1 | nan | ||
| CHEMBL4850812 | 184851 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay |
ChEMBL | 398 | 4 | 1 | 4 | 3.9 | NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1 | nan | ||
Showing 1 to 50 of 648 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 156735309 | 194251 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 404 | 3 | 1 | 4 | 3.6 | Cc1nn(-c2cncc(Cc3cc(F)cc(C(F)(F)F)c3)c2)c2c1C(=O)NCC2 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5282094 | 194251 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 404 | 3 | 1 | 4 | 3.6 | Cc1nn(-c2cncc(Cc3cc(F)cc(C(F)(F)F)c3)c2)c2c1C(=O)NCC2 | 10.1021/acsmedchemlett.3c00052 | ||
| 156735541 | 194478 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 390 | 3 | 1 | 4 | 3.3 | O=C1NCCc2c1cnn2-c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5287006 | 194478 | None | 0 | Human | Binding | pEC50 | = | 8 | 8.0 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 390 | 3 | 1 | 4 | 3.3 | O=C1NCCc2c1cnn2-c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1 | 10.1021/acsmedchemlett.3c00052 | ||
| 156735292 | 194182 | None | 0 | Human | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 390 | 3 | 1 | 4 | 3.3 | O=C1NCCc2c1cnn2-c1cncc(Cc2cc(F)cc(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5280513 | 194182 | None | 0 | Human | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 390 | 3 | 1 | 4 | 3.3 | O=C1NCCc2c1cnn2-c1cncc(Cc2cc(F)cc(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| 156735648 | 194584 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 389 | 3 | 1 | 3 | 3.9 | O=C1NCCc2c1cnn2-c1cccc(Cc2cc(F)cc(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5289682 | 194584 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 389 | 3 | 1 | 3 | 3.9 | O=C1NCCc2c1cnn2-c1cccc(Cc2cc(F)cc(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| 156735572 | 194510 | None | 0 | Human | Binding | pEC50 | = | 7.7 | 7.7 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 372 | 4 | 1 | 4 | 3.2 | O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5287950 | 194510 | None | 0 | Human | Binding | pEC50 | = | 7.7 | 7.7 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 372 | 4 | 1 | 4 | 3.2 | O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| 156735464 | 194058 | None | 0 | Human | Binding | pEC50 | = | 8.6 | 8.6 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 386 | 4 | 1 | 4 | 3.5 | Cc1nn(-c2ccnc(Cc3cc(F)cc(C(F)F)c3)c2)c2c1C(=O)NCC2 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5277794 | 194058 | None | 0 | Human | Binding | pEC50 | = | 8.6 | 8.6 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 386 | 4 | 1 | 4 | 3.5 | Cc1nn(-c2ccnc(Cc3cc(F)cc(C(F)F)c3)c2)c2c1C(=O)NCC2 | 10.1021/acsmedchemlett.3c00052 | ||
| 156735279 | 193901 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 404 | 3 | 0 | 4 | 3.6 | CN1CCc2c(cnn2-c2cc(Cc3cc(F)cc(C(F)(F)F)c3)ccn2)C1=O | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5274093 | 193901 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 404 | 3 | 0 | 4 | 3.6 | CN1CCc2c(cnn2-c2cc(Cc3cc(F)cc(C(F)(F)F)c3)ccn2)C1=O | 10.1021/acsmedchemlett.3c00052 | ||
| 171347738 | 194374 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 371 | 3 | 0 | 4 | 4.4 | O=C1CCCc2c1cnn2-c1cc(Cc2cccc(C(F)(F)F)c2)ccn1 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5284809 | 194374 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 371 | 3 | 0 | 4 | 4.4 | O=C1CCCc2c1cnn2-c1cc(Cc2cccc(C(F)(F)F)c2)ccn1 | 10.1021/acsmedchemlett.3c00052 | ||
| 156735268 | 193817 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 376 | 3 | 1 | 4 | 3.3 | O=C1NCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5272124 | 193817 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 376 | 3 | 1 | 4 | 3.3 | O=C1NCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| 156735500 | 194360 | None | 8 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 390 | 3 | 1 | 4 | 3.3 | O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5284353 | 194360 | None | 8 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 390 | 3 | 1 | 4 | 3.3 | O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| 156735265 | 194095 | None | 0 | Human | Binding | pEC50 | = | 8.4 | 8.4 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 404 | 3 | 1 | 4 | 3.6 | Cc1nn(-c2ccnc(Cc3cc(F)cc(C(F)(F)F)c3)c2)c2c1C(=O)NCC2 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5278598 | 194095 | None | 0 | Human | Binding | pEC50 | = | 8.4 | 8.4 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 404 | 3 | 1 | 4 | 3.6 | Cc1nn(-c2ccnc(Cc3cc(F)cc(C(F)(F)F)c3)c2)c2c1C(=O)NCC2 | 10.1021/acsmedchemlett.3c00052 | ||
| 156735500 | 194360 | None | 8 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 390 | 3 | 1 | 4 | 3.3 | O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5284353 | 194360 | None | 8 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 390 | 3 | 1 | 4 | 3.3 | O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| 90645439 | 112600 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin) |
ChEMBL | 414 | 8 | 2 | 4 | 3.9 | O=C(NCCO)c1cccc(-c2cccc(OCCc3cc(F)cc(Cl)c3)n2)c1 | 10.1021/jm5002919 | ||
| CHEMBL3299118 | 112600 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin) |
ChEMBL | 414 | 8 | 2 | 4 | 3.9 | O=C(NCCO)c1cccc(-c2cccc(OCCc3cc(F)cc(Cl)c3)n2)c1 | 10.1021/jm5002919 | ||
| 156735485 | 194081 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 424 | 3 | 1 | 4 | 4.0 | O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)c(Cl)c(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5278255 | 194081 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 424 | 3 | 1 | 4 | 4.0 | O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)c(Cl)c(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| 156735329 | 193894 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 404 | 3 | 1 | 4 | 3.7 | O=C1NCCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5273936 | 193894 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 404 | 3 | 1 | 4 | 3.7 | O=C1NCCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| 156735482 | 194634 | None | 0 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 390 | 3 | 1 | 4 | 3.3 | O=C1NCCc2nn(-c3ccnc(Cc4cc(F)cc(C(F)(F)F)c4)c3)cc21 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5291296 | 194634 | None | 0 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 390 | 3 | 1 | 4 | 3.3 | O=C1NCCc2nn(-c3ccnc(Cc4cc(F)cc(C(F)(F)F)c4)c3)cc21 | 10.1021/acsmedchemlett.3c00052 | ||
| 156735504 | 194488 | None | 0 | Human | Binding | pEC50 | = | 8.2 | 8.2 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 402 | 5 | 1 | 5 | 3.2 | Cc1nn(-c2ccnc(Cc3cc(F)cc(OC(F)F)c3)c2)c2c1C(=O)NCC2 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5287320 | 194488 | None | 0 | Human | Binding | pEC50 | = | 8.2 | 8.2 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 402 | 5 | 1 | 5 | 3.2 | Cc1nn(-c2ccnc(Cc3cc(F)cc(OC(F)F)c3)c2)c2c1C(=O)NCC2 | 10.1021/acsmedchemlett.3c00052 | ||
| 156735352 | 193811 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 372 | 3 | 1 | 4 | 3.2 | O=C1NCCc2c1cnn2-c1cc(Cc2cccc(C(F)(F)F)c2)ccn1 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5271921 | 193811 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 372 | 3 | 1 | 4 | 3.2 | O=C1NCCc2c1cnn2-c1cc(Cc2cccc(C(F)(F)F)c2)ccn1 | 10.1021/acsmedchemlett.3c00052 | ||
| 156735378 | 193611 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 391 | 3 | 1 | 5 | 2.7 | O=C1NCCc2c1nnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| CHEMBL5267002 | 193611 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis |
ChEMBL | 391 | 3 | 1 | 5 | 2.7 | O=C1NCCc2c1nnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1 | 10.1021/acsmedchemlett.3c00052 | ||
| 44206579 | 112599 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin) |
ChEMBL | 430 | 8 | 2 | 4 | 4.1 | O=C(NCCO)c1cccc(-c2cccc(OCCc3cccc(C(F)(F)F)c3)n2)c1 | 10.1021/jm5002919 | ||
| CHEMBL3299117 | 112599 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin) |
ChEMBL | 430 | 8 | 2 | 4 | 4.1 | O=C(NCCO)c1cccc(-c2cccc(OCCc3cccc(C(F)(F)F)c3)n2)c1 | 10.1021/jm5002919 | ||
| 56649300 | 157863 | None | 30 | Mouse | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | Agonist activity at mouse GPR52Agonist activity at mouse GPR52 |
ChEMBL | 392 | 4 | 1 | 4 | 3.7 | Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O | 10.1016/j.bmc.2017.03.064 | ||
| CHEMBL4082756 | 157863 | None | 30 | Mouse | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | Agonist activity at mouse GPR52Agonist activity at mouse GPR52 |
ChEMBL | 392 | 4 | 1 | 4 | 3.7 | Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O | 10.1016/j.bmc.2017.03.064 | ||
| 56649300 | 157863 | None | 30 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52 |
ChEMBL | 392 | 4 | 1 | 4 | 3.7 | Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O | 10.6019/CHEMBL5210121 | ||
| CHEMBL4082756 | 157863 | None | 30 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52 |
ChEMBL | 392 | 4 | 1 | 4 | 3.7 | Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O | 10.6019/CHEMBL5210121 | ||
| 171353011 | 194120 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin) |
ChEMBL | 372 | 2 | 0 | 6 | 2.9 | C=C1C(=O)O[C@@H]2C/C=C(\C)CC3C=C(C[C@H](OC(=O)/C(C)=C\C)[C@@H]12)C(=O)O3 | 10.1021/acs.jmedchem.2c00799 | ||
| CHEMBL5279049 | 194120 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin) |
ChEMBL | 372 | 2 | 0 | 6 | 2.9 | C=C1C(=O)O[C@@H]2C/C=C(\C)CC3C=C(C[C@H](OC(=O)/C(C)=C\C)[C@@H]12)C(=O)O3 | 10.1021/acs.jmedchem.2c00799 | ||
| 5316932 | 91578 | None | 20 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin) |
ChEMBL | 264 | 7 | 0 | 1 | 4.4 | O=C(/C=C/CCc1ccccc1)CCc1ccccc1 | 10.1021/acs.jmedchem.2c00799 | ||
| CHEMBL240484 | 91578 | None | 20 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin) |
ChEMBL | 264 | 7 | 0 | 1 | 4.4 | O=C(/C=C/CCc1ccccc1)CCc1ccccc1 | 10.1021/acs.jmedchem.2c00799 | ||
| 156588927 | 182254 | None | 23 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin) |
ChEMBL | 242 | 5 | 0 | 2 | 4.1 | O=C(/C=C/CCc1ccccc1)c1cccs1 | 10.1021/acs.jmedchem.2c00799 | ||
| CHEMBL4782344 | 182254 | None | 23 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin) |
ChEMBL | 242 | 5 | 0 | 2 | 4.1 | O=C(/C=C/CCc1ccccc1)c1cccs1 | 10.1021/acs.jmedchem.2c00799 | ||
Showing 1 to 50 of 52 entries