Ligand source activities (1 row/activity)



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 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

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 DOI
11212 165 None 0 Human Functional pEC50 = 9.7 9.7 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
127045422 165 None 0 Human Functional pEC50 = 9.7 9.7 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
CHEMBL3828298 165 None 0 Human Functional pEC50 = 9.7 9.7 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
11212 165 None 0 Human Functional pEC50 = 9.5 9.5 - 1
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
127045422 165 None 0 Human Functional pEC50 = 9.5 9.5 - 1
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
CHEMBL3828298 165 None 0 Human Functional pEC50 = 9.5 9.5 - 1
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
11211 4152 None 29 Human Functional pEC50 = 9.1 9.1 -2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
1912564 4152 None 29 Human Functional pEC50 = 9.1 9.1 -2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827756 4152 None 29 Human Functional pEC50 = 9.1 9.1 -2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
11211 4152 None 29 Human Functional pEC50 = 9 9.0 -2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
1912564 4152 None 29 Human Functional pEC50 = 9 9.0 -2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827756 4152 None 29 Human Functional pEC50 = 9 9.0 -2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
54678947 23038 None 2 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 209 6 2 3 3.0 CCCCCCCc1cc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL13302 23038 None 2 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 209 6 2 3 3.0 CCCCCCCc1cc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
127044155 141148 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 223 7 2 3 3.4 CCCCCCCCc1cc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827638 141148 None 0 Human Functional pEC50 = 8.9 8.9 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 223 7 2 3 3.4 CCCCCCCCc1cc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
23646340 84320 None 0 Human Functional pEC50 = 8.8 8.8 - 1
Agonist activity at human GPR84 expressed in HEK293 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 60 mins by HTRF assayAgonist activity at human GPR84 expressed in HEK293 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 60 mins by HTRF assay
ChEMBL 252 7 2 4 3.1 CCCCCCCCC1=C(O)C(=O)C=C(O)C1=O 10.1021/acs.jmedchem.0c01378
CHEMBL221598 84320 None 0 Human Functional pEC50 = 8.8 8.8 - 1
Agonist activity at human GPR84 expressed in HEK293 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 60 mins by HTRF assayAgonist activity at human GPR84 expressed in HEK293 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 60 mins by HTRF assay
ChEMBL 252 7 2 4 3.1 CCCCCCCCC1=C(O)C(=O)C=C(O)C1=O 10.1021/acs.jmedchem.0c01378
11208 1422 None 113 Human Functional pEC50 = 6 6.0 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
3071 1422 None 113 Human Functional pEC50 = 6 6.0 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
CHEMBL446452 1422 None 113 Human Functional pEC50 = 6 6.0 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
DB11875 1422 None 113 Human Functional pEC50 = 6 6.0 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
137656606 159606 None 0 Human Functional pEC50 = 5 5.0 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 304 3 2 2 4.0 COC(=O)c1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4103279 159606 None 0 Human Functional pEC50 = 5 5.0 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 304 3 2 2 4.0 COC(=O)c1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
3893 2285 None 98 Human Functional pEC50 = 5.0 5.0 -3 4
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
4642 2285 None 98 Human Functional pEC50 = 5.0 5.0 -3 4
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
5534 2285 None 98 Human Functional pEC50 = 5.0 5.0 -3 4
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
CHEMBL108766 2285 None 98 Human Functional pEC50 = 5.0 5.0 -3 4
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
DB03017 2285 None 98 Human Functional pEC50 = 5.0 5.0 -3 4
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
10354234 164 None 46 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as increase in myo-[3H]inositol phosphate accumulation measured after 2 hrs by topcount scintillation counting methodAgonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as increase in myo-[3H]inositol phosphate accumulation measured after 2 hrs by topcount scintillation counting method
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5846 164 None 46 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as increase in myo-[3H]inositol phosphate accumulation measured after 2 hrs by topcount scintillation counting methodAgonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as increase in myo-[3H]inositol phosphate accumulation measured after 2 hrs by topcount scintillation counting method
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827832 164 None 46 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as increase in myo-[3H]inositol phosphate accumulation measured after 2 hrs by topcount scintillation counting methodAgonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as increase in myo-[3H]inositol phosphate accumulation measured after 2 hrs by topcount scintillation counting method
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
3893 2285 None 98 Human Functional pEC50 = 5.0 5.0 -3 4
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
4642 2285 None 98 Human Functional pEC50 = 5.0 5.0 -3 4
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
5534 2285 None 98 Human Functional pEC50 = 5.0 5.0 -3 4
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
CHEMBL108766 2285 None 98 Human Functional pEC50 = 5.0 5.0 -3 4
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
DB03017 2285 None 98 Human Functional pEC50 = 5.0 5.0 -3 4
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
127044004 141172 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 290 7 2 5 3.4 Oc1cc(O)nc(SCCCCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827935 141172 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 290 7 2 5 3.4 Oc1cc(O)nc(SCCCCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
137658184 159749 None 0 Human Functional pEC50 = 5.0 5.0 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 350 2 2 0 5.8 Fc1cc2c(Cc3c[nH]c4cc(Cl)c(F)cc34)c[nH]c2cc1Cl 10.1021/acs.jmedchem.6b01593
CHEMBL4104992 159749 None 0 Human Functional pEC50 = 5.0 5.0 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 350 2 2 0 5.8 Fc1cc2c(Cc3c[nH]c4cc(Cl)c(F)cc34)c[nH]c2cc1Cl 10.1021/acs.jmedchem.6b01593
127044149 141139 None 0 Human Functional pEC50 = 7.9 7.9 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 224 7 2 4 2.8 CCCCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827580 141139 None 0 Human Functional pEC50 = 7.9 7.9 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 224 7 2 4 2.8 CCCCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
11208 1422 None 113 Human Functional pEC50 = 5.0 5.0 2 2
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
3071 1422 None 113 Human Functional pEC50 = 5.0 5.0 2 2
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
CHEMBL446452 1422 None 113 Human Functional pEC50 = 5.0 5.0 2 2
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
DB11875 1422 None 113 Human Functional pEC50 = 5.0 5.0 2 2
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by top-count liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
11208 1422 None 113 Human Functional pEC50 = 6.0 6.0 2 2
Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
3071 1422 None 113 Human Functional pEC50 = 6.0 6.0 2 2
Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
CHEMBL446452 1422 None 113 Human Functional pEC50 = 6.0 6.0 2 2
Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
DB11875 1422 None 113 Human Functional pEC50 = 6.0 6.0 2 2
Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
153309768 192828 None 0 Human Functional pEC50 = 6.0 6.0 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5179395 192828 None 0 Human Functional pEC50 = 6.0 6.0 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221639 192828 None 0 Human Functional pEC50 = 6.0 6.0 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
137635702 156045 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1cccc2c(Cc3c[nH]c4c(F)cccc34)c[nH]c12 10.1021/acs.jmedchem.6b01593
CHEMBL4062512 156045 None 0 Human Functional pEC50 = 7.0 7.0 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1cccc2c(Cc3c[nH]c4c(F)cccc34)c[nH]c12 10.1021/acs.jmedchem.6b01593
127045478 141218 None 0 Human Functional pEC50 = 5.0 5.0 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 368 16 2 5 6.5 CCCCCCCCCCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828578 141218 None 0 Human Functional pEC50 = 5.0 5.0 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 368 16 2 5 6.5 CCCCCCCCCCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
137632827 156391 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 314 2 2 0 5.5 Clc1cccc2[nH]cc(Cc3c[nH]c4cccc(Cl)c34)c12 10.1021/acs.jmedchem.6b01593
CHEMBL4066454 156391 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 314 2 2 0 5.5 Clc1cccc2[nH]cc(Cc3c[nH]c4cccc(Cl)c34)c12 10.1021/acs.jmedchem.6b01593
11005 2692 None 107 Human Functional pEC50 = 4.9 4.9 -1 3
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2806 2692 None 107 Human Functional pEC50 = 4.9 4.9 -1 3
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL111077 2692 None 107 Human Functional pEC50 = 4.9 4.9 -1 3
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB08231 2692 None 107 Human Functional pEC50 = 4.9 4.9 -1 3
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
137643701 158276 None 0 Human Functional pEC50 = 4.9 4.9 -2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.01 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.01 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4088884 158276 None 0 Human Functional pEC50 = 4.9 4.9 -2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.01 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.01 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
137643701 158276 None 0 Human Functional pEC50 = 6.9 6.9 -2 2
Agonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
CHEMBL4088884 158276 None 0 Human Functional pEC50 = 6.9 6.9 -2 2
Agonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
127043534 141153 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 312 12 2 5 4.9 CCCCCCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827684 141153 None 0 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 312 12 2 5 4.9 CCCCCCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
11210 3210 None 1 Human Functional pEC50 = 7.9 7.9 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 265 4 3 3 1.4 Clc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.0c01378
146025748 3210 None 1 Human Functional pEC50 = 7.9 7.9 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 265 4 3 3 1.4 Clc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL4538049 3210 None 1 Human Functional pEC50 = 7.9 7.9 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 265 4 3 3 1.4 Clc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.0c01378
127044143 141224 None 0 Human Functional pEC50 = 7.9 7.9 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 210 6 2 4 2.4 CCCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828708 141224 None 0 Human Functional pEC50 = 7.9 7.9 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 210 6 2 4 2.4 CCCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
11211 4152 None 29 Mouse Functional pEC50 = 7.9 7.9 2 2
Agonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
1912564 4152 None 29 Mouse Functional pEC50 = 7.9 7.9 2 2
Agonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3827756 4152 None 29 Mouse Functional pEC50 = 7.9 7.9 2 2
Agonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
10354234 164 None 46 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5846 164 None 46 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827832 164 None 46 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
11208 1422 None 113 Human Functional pEC50 = 5.9 5.9 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
3071 1422 None 113 Human Functional pEC50 = 5.9 5.9 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
CHEMBL446452 1422 None 113 Human Functional pEC50 = 5.9 5.9 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
DB11875 1422 None 113 Human Functional pEC50 = 5.9 5.9 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
5849 66 None 44 Human Functional pEC50 = 4.9 4.9 -1 2
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCCC(C(=O)O)O 10.1039/C7MD00130D
97783 66 None 44 Human Functional pEC50 = 4.9 4.9 -1 2
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCCC(C(=O)O)O 10.1039/C7MD00130D
CHEMBL4278254 66 None 44 Human Functional pEC50 = 4.9 4.9 -1 2
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCCC(C(=O)O)O 10.1039/C7MD00130D
5850 100 None 63 Human Functional pEC50 = 4.9 4.9 - 1
Agonist activity at human Gialpha-coupled GPR84 expressed in baculovirus infected sf9 insect cells assessed as induction of [35S]GTPgammaS incubated for 1 hr by liquid scintillation counting methodAgonist activity at human Gialpha-coupled GPR84 expressed in baculovirus infected sf9 insect cells assessed as induction of [35S]GTPgammaS incubated for 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.0c01378
94216 100 None 63 Human Functional pEC50 = 4.9 4.9 - 1
Agonist activity at human Gialpha-coupled GPR84 expressed in baculovirus infected sf9 insect cells assessed as induction of [35S]GTPgammaS incubated for 1 hr by liquid scintillation counting methodAgonist activity at human Gialpha-coupled GPR84 expressed in baculovirus infected sf9 insect cells assessed as induction of [35S]GTPgammaS incubated for 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.0c01378
CHEMBL4288936 100 None 63 Human Functional pEC50 = 4.9 4.9 - 1
Agonist activity at human Gialpha-coupled GPR84 expressed in baculovirus infected sf9 insect cells assessed as induction of [35S]GTPgammaS incubated for 1 hr by liquid scintillation counting methodAgonist activity at human Gialpha-coupled GPR84 expressed in baculovirus infected sf9 insect cells assessed as induction of [35S]GTPgammaS incubated for 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.0c01378
5850 100 None 63 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
94216 100 None 63 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
CHEMBL4288936 100 None 63 Human Functional pEC50 = 5.9 5.9 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
11211 4152 None 29 Human Functional pEC50 = 6.9 6.9 -2 2
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
1912564 4152 None 29 Human Functional pEC50 = 6.9 6.9 -2 2
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827756 4152 None 29 Human Functional pEC50 = 6.9 6.9 -2 2
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
11211 4152 None 29 Human Functional pEC50 = 6.9 6.9 -2 2
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
1912564 4152 None 29 Human Functional pEC50 = 6.9 6.9 -2 2
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
CHEMBL3827756 4152 None 29 Human Functional pEC50 = 6.9 6.9 -2 2
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
11211 4152 None 29 Human Functional pEC50 = 6.8 6.8 -2 2
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
1912564 4152 None 29 Human Functional pEC50 = 6.8 6.8 -2 2
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
CHEMBL3827756 4152 None 29 Human Functional pEC50 = 6.8 6.8 -2 2
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acsmedchemlett.6b00025
11005 2692 None 107 Human Functional pEC50 = 4.8 4.8 -1 3
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
2806 2692 None 107 Human Functional pEC50 = 4.8 4.8 -1 3
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
CHEMBL111077 2692 None 107 Human Functional pEC50 = 4.8 4.8 -1 3
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
DB08231 2692 None 107 Human Functional pEC50 = 4.8 4.8 -1 3
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
16064 171042 None 71 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCC(O)CC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL4456892 171042 None 71 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCC(O)CC(=O)O 10.1021/acs.jmedchem.9b01339
11211 4152 None 29 Human Functional pEC50 = 7.8 7.8 -2 2
Agonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
1912564 4152 None 29 Human Functional pEC50 = 7.8 7.8 -2 2
Agonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3827756 4152 None 29 Human Functional pEC50 = 7.8 7.8 -2 2
Agonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
10354234 164 None 46 Human Functional pEC50 = 7.8 7.8 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5846 164 None 46 Human Functional pEC50 = 7.8 7.8 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827832 164 None 46 Human Functional pEC50 = 7.8 7.8 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5533 3941 None 104 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
8180 3941 None 104 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL108030 3941 None 104 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5288266 16440 None 47 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCC[C@@H](O)CC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL1232858 16440 None 47 Human Functional pEC50 = 5.8 5.8 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCC[C@@H](O)CC(=O)O 10.1021/acs.jmedchem.9b01339
137643701 158276 None 0 Mouse Functional pEC50 = 6.8 6.8 2 2
Agonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
CHEMBL4088884 158276 None 0 Mouse Functional pEC50 = 6.8 6.8 2 2
Agonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
153309768 192828 None 0 Human Functional pEC50 = 5.8 5.8 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5179395 192828 None 0 Human Functional pEC50 = 5.8 5.8 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221639 192828 None 0 Human Functional pEC50 = 5.8 5.8 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
137649817 157409 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 318 2 2 0 4.8 Fc1cc2[nH]cc(Cc3c[nH]c4cc(F)c(F)cc34)c2cc1F 10.1021/acs.jmedchem.6b01593
CHEMBL4078546 157409 None 0 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 318 2 2 0 4.8 Fc1cc2[nH]cc(Cc3c[nH]c4cc(F)c(F)cc34)c2cc1F 10.1021/acs.jmedchem.6b01593
102583156 158915 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 276 3 2 1 4.2 COc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4095532 158915 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 276 3 2 1 4.2 COc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
10354234 164 None 46 Human Functional pEC50 = 7.7 7.7 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.0c01378
5846 164 None 46 Human Functional pEC50 = 7.7 7.7 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3827832 164 None 46 Human Functional pEC50 = 7.7 7.7 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.0c01378
133081959 3211 None 1 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 309 4 3 3 1.5 Brc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
9871 3211 None 1 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 309 4 3 3 1.5 Brc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4444010 3211 None 1 Human Functional pEC50 = 8.6 8.6 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 309 4 3 3 1.5 Brc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
11209 1550 None 95 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
3218 1550 None 95 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL221137 1550 None 95 Human Functional pEC50 = 6.7 6.7 - 1
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
135373094 1356 None 95 Human Functional pEC50 = 4.7 4.7 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1356 None 95 Human Functional pEC50 = 4.7 4.7 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1356 None 95 Human Functional pEC50 = 4.7 4.7 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1356 None 95 Human Functional pEC50 = 4.7 4.7 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1356 None 95 Human Functional pEC50 = 4.7 4.7 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assayAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as inhibition of forskolin-induced cAMP production measured after 30 mins by HTRF assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
79034 195204 None 100 Human Functional pEC50 = 4.7 4.7 - 1
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 11 2 2 3.0 O=C(O)CCCCCCCCCCCO 10.1039/C7MD00130D
CHEMBL55068 195204 None 100 Human Functional pEC50 = 4.7 4.7 - 1
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 11 2 2 3.0 O=C(O)CCCCCCCCCCCO 10.1039/C7MD00130D
127044148 141144 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 196 4 2 4 1.9 CC(C)CCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827606 141144 None 0 Human Functional pEC50 = 5.7 5.7 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 196 4 2 4 1.9 CC(C)CCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
11211 4152 None 29 Human Functional pEC50 = 6.7 6.7 -2 2
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
1912564 4152 None 29 Human Functional pEC50 = 6.7 6.7 -2 2
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827756 4152 None 29 Human Functional pEC50 = 6.7 6.7 -2 2
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as increase in intracellular calcium mobilization by Fluo-4 AM dye based fluorescence assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
127045479 141221 None 0 Human Functional pEC50 = 4.7 4.7 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 210 4 2 5 1.4 C#CCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828642 141221 None 0 Human Functional pEC50 = 4.7 4.7 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 210 4 2 5 1.4 C#CCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
10171 1811 None 20 Human Functional pEC50 = 4.7 4.7 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
71616860 1811 None 20 Human Functional pEC50 = 4.7 4.7 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
CHEMBL3716365 1811 None 20 Human Functional pEC50 = 4.7 4.7 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
DB15346 1811 None 20 Human Functional pEC50 = 4.7 4.7 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
127043533 141161 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 242 7 2 5 3.0 CCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827763 141161 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 242 7 2 5 3.0 CCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
660705 38781 None 26 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 214 5 2 5 2.2 CCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL1466478 38781 None 26 Human Functional pEC50 = 5.6 5.6 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 214 5 2 5 2.2 CCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
135373094 1356 None 95 Human Functional pEC50 = 4.6 4.6 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1356 None 95 Human Functional pEC50 = 4.6 4.6 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1356 None 95 Human Functional pEC50 = 4.6 4.6 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1356 None 95 Human Functional pEC50 = 4.6 4.6 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1356 None 95 Human Functional pEC50 = 4.6 4.6 2 2
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
11208 1422 None 113 Human Functional pEC50 = 6.6 6.6 2 2
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
3071 1422 None 113 Human Functional pEC50 = 6.6 6.6 2 2
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
CHEMBL446452 1422 None 113 Human Functional pEC50 = 6.6 6.6 2 2
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
DB11875 1422 None 113 Human Functional pEC50 = 6.6 6.6 2 2
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
127045477 141151 None 0 Human Functional pEC50 = 4.6 4.6 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 340 14 2 5 5.7 CCCCCCCCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827657 141151 None 0 Human Functional pEC50 = 4.6 4.6 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 340 14 2 5 5.7 CCCCCCCCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
11211 4152 None 29 Mouse Functional pEC50 = 7.6 7.6 2 2
Agonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
1912564 4152 None 29 Mouse Functional pEC50 = 7.6 7.6 2 2
Agonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3827756 4152 None 29 Mouse Functional pEC50 = 7.6 7.6 2 2
Agonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
13413723 141164 None 7 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 256 8 2 5 3.3 CCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827862 141164 None 7 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 256 8 2 5 3.3 CCCCCCCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
137649231 157133 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 264 2 2 0 4.4 Fc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4075099 157133 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 264 2 2 0 4.4 Fc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
137643701 158276 None 0 Human Functional pEC50 = 5.6 5.6 -2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4088884 158276 None 0 Human Functional pEC50 = 5.6 5.6 -2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
127044463 141099 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 262 4 2 5 2.7 CCc1ccc(CSc2nc(O)cc(O)n2)cc1 10.1021/acsmedchemlett.6b00025
CHEMBL3827038 141099 None 0 Human Functional pEC50 = 6.6 6.6 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 262 4 2 5 2.7 CCc1ccc(CSc2nc(O)cc(O)n2)cc1 10.1021/acsmedchemlett.6b00025
11211 4152 None 29 Human Functional pEC50 = 7.5 7.5 -2 2
Agonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
1912564 4152 None 29 Human Functional pEC50 = 7.5 7.5 -2 2
Agonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3827756 4152 None 29 Human Functional pEC50 = 7.5 7.5 -2 2
Agonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
153309768 192828 None 0 Human Functional pEC50 = 4.6 4.6 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5179395 192828 None 0 Human Functional pEC50 = 4.6 4.6 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221639 192828 None 0 Human Functional pEC50 = 4.6 4.6 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 10 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
137643701 158276 None 0 Mouse Functional pEC50 = 5.5 5.5 2 2
Agonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
CHEMBL4088884 158276 None 0 Mouse Functional pEC50 = 5.5 5.5 2 2
Agonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
11208 1422 None 113 Human Functional pEC50 = 5.5 5.5 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
3071 1422 None 113 Human Functional pEC50 = 5.5 5.5 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
CHEMBL446452 1422 None 113 Human Functional pEC50 = 5.5 5.5 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
DB11875 1422 None 113 Human Functional pEC50 = 5.5 5.5 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
10171 1811 None 20 Human Functional pEC50 = 5.5 5.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
71616860 1811 None 20 Human Functional pEC50 = 5.5 5.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
CHEMBL3716365 1811 None 20 Human Functional pEC50 = 5.5 5.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
DB15346 1811 None 20 Human Functional pEC50 = 5.5 5.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
137643701 158276 None 0 Mouse Functional pEC50 = 6.5 6.5 2 2
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
CHEMBL4088884 158276 None 0 Mouse Functional pEC50 = 6.5 6.5 2 2
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
127044150 141177 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 238 7 2 4 3.4 CCCCCCCC(C)c1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828004 141177 None 0 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 238 7 2 4 3.4 CCCCCCCC(C)c1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
11211 4152 None 29 Mouse Functional pEC50 = 7.5 7.5 2 2
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
1912564 4152 None 29 Mouse Functional pEC50 = 7.5 7.5 2 2
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3827756 4152 None 29 Mouse Functional pEC50 = 7.5 7.5 2 2
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
135373094 1356 None 95 Human Functional pEC50 = 4.5 4.5 2 2
Agonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1356 None 95 Human Functional pEC50 = 4.5 4.5 2 2
Agonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1356 None 95 Human Functional pEC50 = 4.5 4.5 2 2
Agonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1356 None 95 Human Functional pEC50 = 4.5 4.5 2 2
Agonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1356 None 95 Human Functional pEC50 = 4.5 4.5 2 2
Agonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human N-terminally HA-tagged GPR84 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
26612 99 None 79 Human Functional pEC50 = 4.5 4.5 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 188 8 2 2 2.2 CCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
5848 99 None 79 Human Functional pEC50 = 4.5 4.5 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 188 8 2 2 2.2 CCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
CHEMBL4448230 99 None 79 Human Functional pEC50 = 4.5 4.5 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 188 8 2 2 2.2 CCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
137658671 159446 None 0 Human Functional pEC50 = 6.5 6.5 7 2
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1cccc2[nH]cc(Cc3c[nH]c4cccc(F)c34)c12 10.1021/acs.jmedchem.6b01593
CHEMBL4101219 159446 None 0 Human Functional pEC50 = 6.5 6.5 7 2
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1cccc2[nH]cc(Cc3c[nH]c4cccc(F)c34)c12 10.1021/acs.jmedchem.6b01593
11213 1440 None 5 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 299 4 0 2 3.7 [O-][n+]1cccc(c1)CCOc1ccc(c2c1cccc2)Cl 10.1021/acs.jmedchem.0c01378
154578239 1440 None 5 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 299 4 0 2 3.7 [O-][n+]1cccc(c1)CCOc1ccc(c2c1cccc2)Cl 10.1021/acs.jmedchem.0c01378
CHEMBL4743442 1440 None 5 Human Functional pEC50 = 7.5 7.5 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by luminescence assay
ChEMBL 299 4 0 2 3.7 [O-][n+]1cccc(c1)CCOc1ccc(c2c1cccc2)Cl 10.1021/acs.jmedchem.0c01378
10354234 164 None 46 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5846 164 None 46 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827832 164 None 46 Human Functional pEC50 = 6.5 6.5 - 1
Agonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assayAgonist activity at recombinant human GPR84 stably expressed in HEK293 cells co-expressing Galpha16 assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by HTRF assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
10201214 93575 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 402 2 2 0 5.8 Brc1ccc2[nH]cc(Cc3c[nH]c4ccc(Br)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL246504 93575 None 0 Human Functional pEC50 = 5.5 5.5 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 402 2 2 0 5.8 Brc1ccc2[nH]cc(Cc3c[nH]c4ccc(Br)cc34)c2c1 10.1021/acs.jmedchem.6b01593
137643701 158276 None 0 Human Functional pEC50 = 5.5 5.5 -2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4088884 158276 None 0 Human Functional pEC50 = 5.5 5.5 -2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
9944370 93511 None 4 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 306 4 2 2 4.3 COc1ccc2[nH]cc(Cc3c[nH]c4ccc(OC)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL246298 93511 None 4 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 306 4 2 2 4.3 COc1ccc2[nH]cc(Cc3c[nH]c4ccc(OC)cc34)c2c1 10.1021/acs.jmedchem.6b01593
70233802 141185 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 182 4 2 4 1.6 CCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828115 141185 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 182 4 2 4 1.6 CCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
153309768 192828 None 0 Human Functional pEC50 = 5.4 5.4 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5179395 192828 None 0 Human Functional pEC50 = 5.4 5.4 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221639 192828 None 0 Human Functional pEC50 = 5.4 5.4 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 300 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
137654126 159011 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 318 2 2 0 4.8 Fc1ccc2[nH]cc(Cc3c[nH]c4ccc(F)c(F)c34)c2c1F 10.1021/acs.jmedchem.6b01593
CHEMBL4096571 159011 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 318 2 2 0 4.8 Fc1ccc2[nH]cc(Cc3c[nH]c4ccc(F)c(F)c34)c2c1F 10.1021/acs.jmedchem.6b01593
5282900 18143 None 12 Human Functional pEC50 = 4.4 4.4 - 1
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCC(O)CCC(=O)O 10.1039/C7MD00130D
CHEMBL1269402 18143 None 12 Human Functional pEC50 = 4.4 4.4 - 1
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCC(O)CCC(=O)O 10.1039/C7MD00130D
CHEMBL4283659 18143 None 12 Human Functional pEC50 = 4.4 4.4 - 1
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCC(O)CCC(=O)O 10.1039/C7MD00130D
127043463 141117 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 248 4 2 5 2.2 Oc1cc(O)nc(SCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827283 141117 None 0 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 248 4 2 5 2.2 Oc1cc(O)nc(SCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
1563 72913 None 58 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCCC(O)C(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL2004471 72913 None 58 Human Functional pEC50 = 5.4 5.4 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCCC(O)C(=O)O 10.1021/acs.jmedchem.9b01339
10717 3208 None 4 Human Functional pEC50 = 8.3 8.3 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
44349321 3208 None 4 Human Functional pEC50 = 8.3 8.3 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL124977 3208 None 4 Human Functional pEC50 = 8.3 8.3 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay
ChEMBL 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
137643701 158276 None 0 Human Functional pEC50 = 7.4 7.4 -2 2
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4088884 158276 None 0 Human Functional pEC50 = 7.4 7.4 -2 2
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
11209 1550 None 95 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
3218 1550 None 95 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL221137 1550 None 95 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
11208 1422 None 113 Mouse Functional pEC50 = 5.4 5.4 -2 2
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.0c01378
3071 1422 None 113 Mouse Functional pEC50 = 5.4 5.4 -2 2
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.0c01378
CHEMBL446452 1422 None 113 Mouse Functional pEC50 = 5.4 5.4 -2 2
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.0c01378
DB11875 1422 None 113 Mouse Functional pEC50 = 5.4 5.4 -2 2
Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.0c01378
127045482 141168 None 0 Human Functional pEC50 = 4.4 4.4 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 212 3 2 5 1.8 Oc1cc(O)nc(SCC2CCC2)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827914 141168 None 0 Human Functional pEC50 = 4.4 4.4 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 212 3 2 5 1.8 Oc1cc(O)nc(SCC2CCC2)n1 10.1021/acsmedchemlett.6b00025
127045103 141121 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 276 6 2 5 3.0 Oc1cc(O)nc(SCCCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827310 141121 None 0 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 276 6 2 5 3.0 Oc1cc(O)nc(SCCCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
10354234 164 None 46 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
5846 164 None 46 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
CHEMBL3827832 164 None 46 Human Functional pEC50 = 6.4 6.4 - 1
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assayAgonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
135373094 1356 None 95 Human Functional pEC50 = 5.4 5.4 2 2
Agonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 minsAgonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
2969 1356 None 95 Human Functional pEC50 = 5.4 5.4 2 2
Agonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 minsAgonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
5532 1356 None 95 Human Functional pEC50 = 5.4 5.4 2 2
Agonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 minsAgonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
CHEMBL107498 1356 None 95 Human Functional pEC50 = 5.4 5.4 2 2
Agonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 minsAgonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
DB03600 1356 None 95 Human Functional pEC50 = 5.4 5.4 2 2
Agonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 minsAgonist activity at human N-terminal-FLAG-tagged human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fro 20 mins followed by forskolin addition measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
23042624 141173 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 196 5 2 4 2.0 CCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827946 141173 None 0 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 196 5 2 4 2.0 CCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
135373094 1356 None 95 Human Functional pEC50 = 5.3 5.3 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1356 None 95 Human Functional pEC50 = 5.3 5.3 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1356 None 95 Human Functional pEC50 = 5.3 5.3 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1356 None 95 Human Functional pEC50 = 5.3 5.3 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1356 None 95 Human Functional pEC50 = 5.3 5.3 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
135373094 1356 None 95 Human Functional pEC50 = 5.3 5.3 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1356 None 95 Human Functional pEC50 = 5.3 5.3 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1356 None 95 Human Functional pEC50 = 5.3 5.3 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1356 None 95 Human Functional pEC50 = 5.3 5.3 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1356 None 95 Human Functional pEC50 = 5.3 5.3 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
127044607 141134 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 238 8 2 4 3.2 CCCCCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827526 141134 None 0 Human Functional pEC50 = 7.3 7.3 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 238 8 2 4 3.2 CCCCCCCCCc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
135373094 1356 None 95 Human Functional pEC50 = 4.3 4.3 2 2
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1356 None 95 Human Functional pEC50 = 4.3 4.3 2 2
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1356 None 95 Human Functional pEC50 = 4.3 4.3 2 2
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1356 None 95 Human Functional pEC50 = 4.3 4.3 2 2
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1356 None 95 Human Functional pEC50 = 4.3 4.3 2 2
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
135373094 1356 None 95 Human Functional pEC50 = 4.3 4.3 2 2
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1356 None 95 Human Functional pEC50 = 4.3 4.3 2 2
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1356 None 95 Human Functional pEC50 = 4.3 4.3 2 2
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1356 None 95 Human Functional pEC50 = 4.3 4.3 2 2
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1356 None 95 Human Functional pEC50 = 4.3 4.3 2 2
Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assayAgonist activity at recombinant human GPR84 expressed in CHO cells co-expressing Galpha16/Gqs5/Gqo5/Gqi9 assessed as increase in calcium mobilization measured for 20 secs in presence of coelenterazine by aequorin-reporter gene based luminescence assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
10171 1811 None 20 Human Functional pEC50 = 4.3 4.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
71616860 1811 None 20 Human Functional pEC50 = 4.3 4.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
CHEMBL3716365 1811 None 20 Human Functional pEC50 = 4.3 4.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
DB15346 1811 None 20 Human Functional pEC50 = 4.3 4.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
9901435 158997 None 4 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 314 2 2 0 5.5 Clc1ccc2[nH]cc(Cc3c[nH]c4ccc(Cl)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4096406 158997 None 4 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 314 2 2 0 5.5 Clc1ccc2[nH]cc(Cc3c[nH]c4ccc(Cl)cc34)c2c1 10.1021/acs.jmedchem.6b01593
11208 1422 None 113 Human Functional pEC50 = 6.3 6.3 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
3071 1422 None 113 Human Functional pEC50 = 6.3 6.3 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
CHEMBL446452 1422 None 113 Human Functional pEC50 = 6.3 6.3 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
DB11875 1422 None 113 Human Functional pEC50 = 6.3 6.3 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
10354234 164 None 46 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human GPR84 by [35S]GTPgammaS binding assayAgonist activity at human GPR84 by [35S]GTPgammaS binding assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.6b01593
5846 164 None 46 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human GPR84 by [35S]GTPgammaS binding assayAgonist activity at human GPR84 by [35S]GTPgammaS binding assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.6b01593
CHEMBL3827832 164 None 46 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human GPR84 by [35S]GTPgammaS binding assayAgonist activity at human GPR84 by [35S]GTPgammaS binding assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.6b01593
10354234 164 None 46 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human GPR84 fused with bovine Galphai1 protein expressed in baculovirus infected sf9 cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human GPR84 fused with bovine Galphai1 protein expressed in baculovirus infected sf9 cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
5846 164 None 46 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human GPR84 fused with bovine Galphai1 protein expressed in baculovirus infected sf9 cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human GPR84 fused with bovine Galphai1 protein expressed in baculovirus infected sf9 cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
CHEMBL3827832 164 None 46 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human GPR84 fused with bovine Galphai1 protein expressed in baculovirus infected sf9 cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human GPR84 fused with bovine Galphai1 protein expressed in baculovirus infected sf9 cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
10354234 164 None 46 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr by liquid scintillation counting method
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5846 164 None 46 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr by liquid scintillation counting method
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827832 164 None 46 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr by liquid scintillation counting method
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
11208 1422 None 113 Human Functional pEC50 = 5.3 5.3 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
3071 1422 None 113 Human Functional pEC50 = 5.3 5.3 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
CHEMBL446452 1422 None 113 Human Functional pEC50 = 5.3 5.3 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
DB11875 1422 None 113 Human Functional pEC50 = 5.3 5.3 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
8158 6911 None 92 Human Functional pEC50 = 4.3 4.3 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 158 7 1 1 2.8 CCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
CHEMBL108436 6911 None 92 Human Functional pEC50 = 4.3 4.3 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 158 7 1 1 2.8 CCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
5850 100 None 63 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1039/C7MD00130D
94216 100 None 63 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1039/C7MD00130D
CHEMBL4288936 100 None 63 Human Functional pEC50 = 5.3 5.3 - 1
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting methodAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1039/C7MD00130D
137643701 158276 None 0 Human Functional pEC50 = 6.3 6.3 -2 2
Agonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
CHEMBL4088884 158276 None 0 Human Functional pEC50 = 6.3 6.3 -2 2
Agonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopyAgonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.0c01378
12380289 158190 None 3 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 260 2 2 1 3.9 O=C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.6b01593
CHEMBL4087824 158190 None 3 Human Functional pEC50 = 6.3 6.3 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 260 2 2 1 3.9 O=C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.6b01593
127045635 141207 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 262 5 2 5 2.6 Oc1cc(O)nc(SCCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828415 141207 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 262 5 2 5 2.6 Oc1cc(O)nc(SCCCc2ccccc2)n1 10.1021/acsmedchemlett.6b00025
11208 1422 None 113 Human Functional pEC50 = 5.2 5.2 2 2
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
3071 1422 None 113 Human Functional pEC50 = 5.2 5.2 2 2
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
CHEMBL446452 1422 None 113 Human Functional pEC50 = 5.2 5.2 2 2
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
DB11875 1422 None 113 Human Functional pEC50 = 5.2 5.2 2 2
Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting methodAgonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding measured after 30 mins by liquid scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
127044299 141197 None 0 Human Functional pEC50 = 8.2 8.2 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 239 8 3 5 2.7 CCCCCCCCNc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828303 141197 None 0 Human Functional pEC50 = 8.2 8.2 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 239 8 3 5 2.7 CCCCCCCCNc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
10171 1811 None 20 Human Functional pEC50 = 6.2 6.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
71616860 1811 None 20 Human Functional pEC50 = 6.2 6.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
CHEMBL3716365 1811 None 20 Human Functional pEC50 = 6.2 6.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
DB15346 1811 None 20 Human Functional pEC50 = 6.2 6.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
72711216 157763 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1ccc2c(Cc3c[nH]c4cc(F)ccc34)c[nH]c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4082668 157763 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1ccc2c(Cc3c[nH]c4cc(F)ccc34)c[nH]c2c1 10.1021/acs.jmedchem.6b01593
11208 1422 None 113 Human Functional pEC50 = 5.2 5.2 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
3071 1422 None 113 Human Functional pEC50 = 5.2 5.2 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
CHEMBL446452 1422 None 113 Human Functional pEC50 = 5.2 5.2 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
DB11875 1422 None 113 Human Functional pEC50 = 5.2 5.2 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
11209 1550 None 95 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
3218 1550 None 95 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL221137 1550 None 95 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye based FLIPR assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
11209 1550 None 95 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
3218 1550 None 95 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL221137 1550 None 95 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric methodAgonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes assessed as stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by [35S]GTPgammaS addition and measured 45 mins by liquid scintillation spectrometric method
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
127043349 141192 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 228 5 2 5 2.4 CC(C)CCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828230 141192 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 228 5 2 5 2.4 CC(C)CCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
137643701 158276 None 0 Human Functional pEC50 = 5.2 5.2 -2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.03 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.03 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4088884 158276 None 0 Human Functional pEC50 = 5.2 5.2 -2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.03 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.03 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
10354234 164 None 46 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
5846 164 None 46 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
CHEMBL3827832 164 None 46 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acsmedchemlett.6b00025
127045480 141190 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 224 3 2 5 1.8 CCC#CCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828212 141190 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 224 3 2 5 1.8 CCC#CCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
10171 1811 None 20 Human Functional pEC50 = 6.2 6.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
71616860 1811 None 20 Human Functional pEC50 = 6.2 6.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
CHEMBL3716365 1811 None 20 Human Functional pEC50 = 6.2 6.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
DB15346 1811 None 20 Human Functional pEC50 = 6.2 6.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 6-OAU-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
11208 1422 None 113 Human Functional pEC50 = 6.2 6.2 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
3071 1422 None 113 Human Functional pEC50 = 6.2 6.2 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
CHEMBL446452 1422 None 113 Human Functional pEC50 = 6.2 6.2 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
DB11875 1422 None 113 Human Functional pEC50 = 6.2 6.2 2 2
Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 minsAgonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production preincubated for 20 mins followed by forskolin addition and measured after 20 mins
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
8158 6911 None 92 Human Functional pEC50 = 4.2 4.2 - 1
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 158 7 1 1 2.8 CCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
CHEMBL108436 6911 None 92 Human Functional pEC50 = 4.2 4.2 - 1
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 158 7 1 1 2.8 CCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
135373094 1356 None 95 Human Functional pEC50 = 5.1 5.1 2 2
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
2969 1356 None 95 Human Functional pEC50 = 5.1 5.1 2 2
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
5532 1356 None 95 Human Functional pEC50 = 5.1 5.1 2 2
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
CHEMBL107498 1356 None 95 Human Functional pEC50 = 5.1 5.1 2 2
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
DB03600 1356 None 95 Human Functional pEC50 = 5.1 5.1 2 2
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
5533 3941 None 104 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
8180 3941 None 104 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
CHEMBL108030 3941 None 104 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
11209 1550 None 95 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.6b01593
3218 1550 None 95 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.6b01593
CHEMBL221137 1550 None 95 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.6b01593
9882204 159486 None 17 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1ccc2[nH]cc(Cc3c[nH]c4ccc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4101728 159486 None 17 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 282 2 2 0 4.5 Fc1ccc2[nH]cc(Cc3c[nH]c4ccc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
127044300 141171 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 224 7 2 4 2.8 CCCCCCCCc1cc(O)nc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3827933 141171 None 0 Human Functional pEC50 = 6.1 6.1 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 224 7 2 4 2.8 CCCCCCCCc1cc(O)nc(O)n1 10.1021/acsmedchemlett.6b00025
11208 1422 None 113 Human Functional pEC50 = 5.1 5.1 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
3071 1422 None 113 Human Functional pEC50 = 5.1 5.1 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
CHEMBL446452 1422 None 113 Human Functional pEC50 = 5.1 5.1 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
DB11875 1422 None 113 Human Functional pEC50 = 5.1 5.1 2 2
Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM)
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
153309768 192828 None 0 Human Functional pEC50 = 4.1 4.1 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5179395 192828 None 0 Human Functional pEC50 = 4.1 4.1 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221639 192828 None 0 Human Functional pEC50 = 4.1 4.1 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 30 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
5533 3941 None 104 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
8180 3941 None 104 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
CHEMBL108030 3941 None 104 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting methodAgonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid scintillation counting method
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
3893 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 minsAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 mins
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
4642 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 minsAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 mins
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
5534 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 minsAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 mins
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
CHEMBL108766 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 minsAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 mins
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
DB03017 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 minsAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human GPR84 expressed in CHO cell membranes assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 20 mins followed by forskolin-induction and measured after 20 mins
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1039/C7MD00130D
127044151 141183 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 244 4 2 4 2.2 CCc1ccc(CCc2nc(O)cc(O)n2)cc1 10.1021/acsmedchemlett.6b00025
CHEMBL3828073 141183 None 0 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 244 4 2 4 2.2 CCc1ccc(CCc2nc(O)cc(O)n2)cc1 10.1021/acsmedchemlett.6b00025
3893 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
4642 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
5534 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
CHEMBL108766 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
DB03017 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assayAgonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followed by forskolin stimulation and measured after 20 mins by cAMP assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.0c01378
127044950 141096 None 0 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 196 3 2 5 1.0 C#CCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3826992 141096 None 0 Human Functional pEC50 = 5.1 5.1 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 196 3 2 5 1.0 C#CCCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
3893 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
4642 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5534 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL108766 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03017 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
11209 1550 None 95 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 60 mins by HTRF assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
3218 1550 None 95 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 60 mins by HTRF assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL221137 1550 None 95 Human Functional pEC50 = 7.1 7.1 - 1
Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 60 mins by HTRF assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
10171 1811 None 20 Human Functional pEC50 = 4.0 4.0 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
71616860 1811 None 20 Human Functional pEC50 = 4.0 4.0 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
CHEMBL3716365 1811 None 20 Human Functional pEC50 = 4.0 4.0 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
DB15346 1811 None 20 Human Functional pEC50 = 4.0 4.0 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysisAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as right shift in 3-OH-C12-induced calcium response curve by measuring agonist EC50 at 100 nM preincubated for 10 mins and measured after 1 min of agonist stimulation by schild plot analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
127045481 141180 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 226 5 2 5 2.3 CC/C=C\CCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
CHEMBL3828033 141180 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 226 5 2 5 2.3 CC/C=C\CCSc1nc(O)cc(O)n1 10.1021/acsmedchemlett.6b00025
12530 5789 None 92 Human Functional pEC50 = 5.0 5.0 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 214 11 1 1 4.4 CCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107874 5789 None 92 Human Functional pEC50 = 5.0 5.0 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 mins by radioactive assay
ChEMBL 214 11 1 1 4.4 CCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
102219032 157359 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 274 2 2 0 4.9 Cc1cccc2[nH]cc(Cc3c[nH]c4cccc(C)c34)c12 10.1021/acs.jmedchem.6b01593
CHEMBL4077871 157359 None 0 Human Functional pEC50 = 6.0 6.0 - 1
Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assayAgonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay
ChEMBL 274 2 2 0 4.9 Cc1cccc2[nH]cc(Cc3c[nH]c4cccc(C)c34)c12 10.1021/acs.jmedchem.6b01593
90242131 133658 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 460 6 0 10 2.6 O=c1nc(OC[C@H]2COc3ncccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
CHEMBL3714891 133658 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 460 6 0 10 2.6 O=c1nc(OC[C@H]2COc3ncccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
75203411 133665 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 392 4 0 7 2.7 COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3714917 133665 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 392 4 0 7 2.7 COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
90239661 133666 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 474 6 0 10 3.0 Cc1cc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)on1 nan
CHEMBL3714918 133666 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 474 6 0 10 3.0 Cc1cc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)on1 nan
76684759 133678 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 6 0 8 3.2 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCC3COc4ccccc4O3)ccc1-2 nan
CHEMBL3714958 133678 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 6 0 8 3.2 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCC3COc4ccccc4O3)ccc1-2 nan
90253121 133701 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 473 5 1 8 2.8 CC(C)CC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3715016 133701 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 473 5 1 8 2.8 CC(C)CC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
76684682 133720 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 477 7 0 9 2.6 CC1(COCc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)COC1 nan
CHEMBL3715069 133720 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 477 7 0 9 2.6 CC1(COCc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)COC1 nan
76684887 133762 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 449 7 0 8 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccccc3[N+](=O)[O-])ccc1-2 nan
CHEMBL3715210 133762 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 449 7 0 8 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccccc3[N+](=O)[O-])ccc1-2 nan
90242140 133765 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 6 0 6 3.9 Cc1ccccc1COc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
CHEMBL3715227 133765 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 6 0 6 3.9 Cc1ccccc1COc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
90240329 133779 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 468 8 0 7 4.1 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOc3cccc(Cl)c3)ccc1-2 nan
CHEMBL3715290 133779 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 468 8 0 7 4.1 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOc3cccc(Cl)c3)ccc1-2 nan
90240601 133781 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 470 6 0 9 2.4 N#CCCOCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3715307 133781 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 470 6 0 9 2.4 N#CCCOCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
76684890 133808 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 526 6 0 9 3.9 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCC3COc4ccccc4O3)ccc1-2 nan
CHEMBL3715436 133808 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 526 6 0 9 3.9 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCC3COc4ccccc4O3)ccc1-2 nan
90239433 133830 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 464 9 0 8 3.5 COc1cccc(OCCOc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
CHEMBL3715513 133830 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 464 9 0 8 3.5 COc1cccc(OCCOc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
90242113 133868 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 465 4 0 9 3.0 N#Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
CHEMBL3715639 133868 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 465 4 0 9 3.0 N#Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
90242191 133870 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 517 6 0 11 3.3 CC(C)(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)no1 nan
CHEMBL3715645 133870 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 517 6 0 11 3.3 CC(C)(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)no1 nan
76685019 133871 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 5 0 9 2.0 N#CCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3715646 133871 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 5 0 9 2.0 N#CCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90241754 133882 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 492 5 1 8 3.5 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 nan
CHEMBL3715684 133882 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 492 5 1 8 3.5 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 nan
90242197 133887 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 445 3 1 8 2.2 CC(C)(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3715691 133887 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 445 3 1 8 2.2 CC(C)(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242312 133919 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 473 5 1 8 3.0 CCC(O)(C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O)CC nan
CHEMBL3715779 133919 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 473 5 1 8 3.0 CCC(O)(C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O)CC nan
76684894 133957 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 525 8 1 8 3.4 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)NCc1ccccc1 nan
CHEMBL3715925 133957 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 525 8 1 8 3.4 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)NCc1ccccc1 nan
90241367 133960 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 484 6 0 9 3.5 CCOc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
CHEMBL3715943 133960 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 484 6 0 9 3.5 CCOc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
127024685 133972 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 545 9 1 12 2.1 CCCn1nnnc1NC(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3715985 133972 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 545 9 1 12 2.1 CCCn1nnnc1NC(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
76685016 133973 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 530 8 0 10 4.0 CCOC(=O)c1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ccccc4O3)nc2=O)o1 nan
CHEMBL3715990 133973 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 530 8 0 10 4.0 CCOC(=O)c1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ccccc4O3)nc2=O)o1 nan
90241697 134010 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 464 9 0 8 3.5 COc1ccccc1OCCOc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
CHEMBL3716125 134010 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 464 9 0 8 3.5 COc1ccccc1OCCOc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
76684889 134028 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 492 6 0 9 3.4 CC(C)(C)OC(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3716166 134028 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 492 6 0 9 3.4 CC(C)(C)OC(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
90242169 134032 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 443 4 0 9 2.5 Cn1cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
CHEMBL3716178 134032 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 443 4 0 9 2.5 Cn1cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
76684664 134036 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 342 4 0 6 2.4 COc1ccc2c(c1)CCn1c-2cc(OCC2CCCCO2)nc1=O nan
CHEMBL3716185 134036 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 342 4 0 6 2.4 COc1ccc2c(c1)CCn1c-2cc(OCC2CCCCO2)nc1=O nan
76685018 134041 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 472 7 0 9 3.7 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3noc(-c4ccccc4)n3)ccc1-2 nan
CHEMBL3716202 134041 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 472 7 0 9 3.7 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3noc(-c4ccccc4)n3)ccc1-2 nan
90239903 134050 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 4 0 8 3.3 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3ccoc3)ccc1-2 nan
CHEMBL3716242 134050 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 4 0 8 3.3 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3ccoc3)ccc1-2 nan
76685012 134052 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 434 7 0 7 3.6 COc1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
CHEMBL3716251 134052 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 434 7 0 7 3.6 COc1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
90240535 134076 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 7 0 8 3.4 COC(=O)c1cccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
CHEMBL3716311 134076 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 7 0 8 3.4 COC(=O)c1cccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
76684492 134093 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 463 6 0 8 2.2 CN(C)C(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3716369 134093 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 463 6 0 8 2.2 CN(C)C(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
90242224 134101 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 511 7 1 8 3.7 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)Nc1ccccc1 nan
CHEMBL3716399 134101 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 511 7 1 8 3.7 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)Nc1ccccc1 nan
127024189 134111 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 559 10 1 12 2.5 CCCCn1nnnc1NC(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3716438 134111 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 559 10 1 12 2.5 CCCCn1nnnc1NC(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
90242703 134113 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 499 6 0 9 3.8 COc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1OC nan
CHEMBL3716443 134113 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 499 6 0 9 3.8 COc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1OC nan
76684665 134122 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 6 0 7 3.5 N#Cc1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
CHEMBL3716482 134122 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 6 0 7 3.5 N#Cc1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
90241463 134163 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 499 6 0 9 3.8 COc1ccc(OC)c(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1 nan
CHEMBL3716622 134163 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 499 6 0 9 3.8 COc1ccc(OC)c(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1 nan
90253113 134194 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 6 0 7 3.5 N#Cc1ccccc1COc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
CHEMBL3716734 134194 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 6 0 7 3.5 N#Cc1ccccc1COc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
76684577 134201 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 6 0 8 3.2 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCC3CCCO3)ccc1-2 nan
CHEMBL3716761 134201 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 6 0 8 3.2 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCC3CCCO3)ccc1-2 nan
90253082 134216 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 459 4 2 8 1.1 NC(=O)NCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3716815 134216 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 459 4 2 8 1.1 NC(=O)NCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242227 134220 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 445 4 1 8 2.2 CCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3716828 134220 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 445 4 1 8 2.2 CCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
76684578 134252 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 470 6 0 9 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 nan
CHEMBL3716925 134252 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 470 6 0 9 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 nan
90241694 134253 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 503 7 0 11 3.2 CC(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)no1 nan
CHEMBL3716930 134253 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 503 7 0 11 3.2 CC(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)no1 nan
90240538 134282 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 484 6 0 9 3.5 CCOc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3717010 134282 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 484 6 0 9 3.5 CCOc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242083 134300 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 501 7 0 11 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 nan
CHEMBL3717081 134300 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 501 7 0 11 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 nan
90240045 134327 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 440 4 0 8 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3ccncc3)ccc1-2 nan
CHEMBL3717169 134327 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 440 4 0 8 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3ccncc3)ccc1-2 nan
90242133 134347 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 459 6 1 10 2.7 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(NCc3ncco3)ccc1-2 nan
CHEMBL3717255 134347 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 459 6 1 10 2.7 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(NCc3ncco3)ccc1-2 nan
90241718 134351 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 470 5 0 9 3.2 COc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3717267 134351 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 470 5 0 9 3.2 COc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242208 134362 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 438 6 0 6 4.3 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccc(Cl)cc3)ccc1-2 nan
CHEMBL3717318 134362 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 438 6 0 6 4.3 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccc(Cl)cc3)ccc1-2 nan
90253075 134364 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 506 8 0 10 1.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(COCCN3CCOCC3)ccc1-2 nan
CHEMBL3717323 134364 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 506 8 0 10 1.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(COCCN3CCOCC3)ccc1-2 nan
76684765 134366 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 491 7 0 8 2.9 CC(C)N(C)C(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3717326 134366 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 491 7 0 8 2.9 CC(C)N(C)C(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
90242015 134378 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 449 7 0 8 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccc([N+](=O)[O-])cc3)ccc1-2 nan
CHEMBL3717358 134378 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 449 7 0 8 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccc([N+](=O)[O-])cc3)ccc1-2 nan
90242171 134411 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 500 7 0 11 2.6 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCc3nnnn3C3CC3)ccc1-2 nan
CHEMBL3717472 134411 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 500 7 0 11 2.6 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCc3nnnn3C3CC3)ccc1-2 nan
76685013 134449 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 454 6 0 6 4.8 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccc4ccccc4c3)ccc1-2 nan
CHEMBL3717594 134449 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 454 6 0 6 4.8 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccc4ccccc4c3)ccc1-2 nan
76684489 134469 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 468 8 0 7 4.1 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOc3ccc(Cl)cc3)ccc1-2 nan
CHEMBL3717664 134469 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 468 8 0 7 4.1 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOc3ccc(Cl)cc3)ccc1-2 nan
76684573 134479 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 463 6 1 8 2.3 CC(C)(Oc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)C(N)=O nan
CHEMBL3717695 134479 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 463 6 1 8 2.3 CC(C)(Oc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)C(N)=O nan
76684667 134486 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 471 7 0 8 4.3 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc(-c4ccoc4)n3)ccc1-2 nan
CHEMBL3717729 134486 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 471 7 0 8 4.3 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc(-c4ccoc4)n3)ccc1-2 nan
90242431 134501 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 363 3 0 7 2.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1ccccc1-2 nan
CHEMBL3717782 134501 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 363 3 0 7 2.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1ccccc1-2 nan
76685010 134503 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 6 0 6 3.9 Cc1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
CHEMBL3717786 134503 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 6 0 6 3.9 Cc1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
90242313 134511 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 477 6 0 9 3.0 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCC3CCCCO3)ccc1-2 nan
CHEMBL3717805 134511 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 477 6 0 9 3.0 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCC3CCCCO3)ccc1-2 nan
90240227 134547 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 445 4 0 8 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C3=CCOCC3)ccc1-2 nan
CHEMBL3717958 134547 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 445 4 0 8 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C3=CCOCC3)ccc1-2 nan
90241655 134573 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 475 6 0 11 2.4 Cc1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)no1 nan
CHEMBL3718050 134573 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 475 6 0 11 2.4 Cc1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)no1 nan
76684767 134580 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 417 5 0 8 2.6 N#CCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3718064 134580 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 417 5 0 8 2.6 N#CCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
76684888 134606 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 469 6 0 8 3.7 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 nan
CHEMBL3718158 134606 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 469 6 0 8 3.7 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 nan
90253118 134611 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 525 5 0 10 3.0 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3ccc(N4CCOCC4)nc3)ccc1-2 nan
CHEMBL3718169 134611 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 525 5 0 10 3.0 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3ccc(N4CCOCC4)nc3)ccc1-2 nan
90241657 134623 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 444 4 0 8 2.0 CN(C)CC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3718203 134623 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 444 4 0 8 2.0 CN(C)CC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
76684681 134634 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 449 6 0 9 2.0 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(COC3COC3)ccc1-2 nan
CHEMBL3718246 134634 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 449 6 0 9 2.0 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(COC3COC3)ccc1-2 nan
90242333 134638 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 491 7 0 9 2.4 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCCN3CCOCC3)ccc1-2 nan
CHEMBL3718258 134638 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 491 7 0 9 2.4 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCCN3CCOCC3)ccc1-2 nan
90240406 134649 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 504 5 0 9 3.8 COc1nccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1Cl nan
CHEMBL3718281 134649 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 504 5 0 9 3.8 COc1nccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1Cl nan
90242041 134658 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 489 7 0 11 2.6 CCc1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)no1 nan
CHEMBL3718294 134658 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 489 7 0 11 2.6 CCc1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)no1 nan
90242190 134662 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 493 4 1 8 3.2 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CC(O)c3ccccc3)ccc1-2 nan
CHEMBL3718309 134662 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 493 4 1 8 3.2 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CC(O)c3ccccc3)ccc1-2 nan
90242242 134685 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 449 7 0 8 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc([N+](=O)[O-])c3)ccc1-2 nan
CHEMBL3718388 134685 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 449 7 0 8 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc([N+](=O)[O-])c3)ccc1-2 nan
90242259 134709 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 4 1 8 2.5 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3cn[nH]c3)ccc1-2 nan
CHEMBL3718482 134709 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 4 1 8 2.5 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3cn[nH]c3)ccc1-2 nan
76684671 134719 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 447 7 1 7 3.0 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O)Nc1ccccc1 nan
CHEMBL3718511 134719 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 447 7 1 7 3.0 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O)Nc1ccccc1 nan
90242243 134721 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 5 0 9 1.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(CN3CCOCC3)ccc1-2 nan
CHEMBL3718521 134721 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 5 0 9 1.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(CN3CCOCC3)ccc1-2 nan
76684575 134726 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 448 9 0 7 3.6 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOCc3ccccc3)ccc1-2 nan
CHEMBL3718543 134726 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 448 9 0 7 3.6 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOCc3ccccc3)ccc1-2 nan
90242373 134739 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 497 5 1 9 2.5 CNC(=O)c1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
CHEMBL3718580 134739 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 497 5 1 9 2.5 CNC(=O)c1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
90240336 134746 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 427 3 0 7 2.8 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 nan
CHEMBL3718614 134746 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 427 3 0 7 2.8 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 nan
76684490 134751 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 505 6 0 9 1.9 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)N1CCOCC1 nan
CHEMBL3718620 134751 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 505 6 0 9 1.9 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)N1CCOCC1 nan
76684761 134764 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 438 6 0 6 4.3 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc(Cl)c3)ccc1-2 nan
CHEMBL3718642 134764 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 438 6 0 6 4.3 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc(Cl)c3)ccc1-2 nan
76684568 134774 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 404 6 0 6 3.6 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccccc3)ccc1-2 nan
CHEMBL3718668 134774 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 404 6 0 6 3.6 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccccc3)ccc1-2 nan
90240938 134778 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 506 6 1 8 3.2 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCNCc3ccccc3)ccc1-2 nan
CHEMBL3718687 134778 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 506 6 1 8 3.2 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCNCc3ccccc3)ccc1-2 nan
90242357 134781 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 459 4 1 8 2.4 CC(C)C(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3718693 134781 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 459 4 1 8 2.4 CC(C)C(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
76684488 134802 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 468 8 0 7 4.1 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOc3ccccc3Cl)ccc1-2 nan
CHEMBL3718767 134802 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 468 8 0 7 4.1 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOc3ccccc3Cl)ccc1-2 nan
90239965 134817 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 464 4 0 8 3.6 N#Cc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1 nan
CHEMBL3718808 134817 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 464 4 0 8 3.6 N#Cc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1 nan
90242390 134821 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 459 5 1 8 2.6 CCCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3718814 134821 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 459 5 1 8 2.6 CCCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
76685017 134857 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 460 6 0 10 2.6 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
CHEMBL3718963 134857 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 460 6 0 10 2.6 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
90242630 134869 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 471 5 0 10 2.5 COc1ncc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
CHEMBL3719011 134869 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 471 5 0 10 2.5 COc1ncc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
90241703 134870 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 460 5 0 8 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(CN3CCCCC3)ccc1-2 nan
CHEMBL3719012 134870 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 460 5 0 8 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(CN3CCCCC3)ccc1-2 nan
76684663 134879 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 434 8 0 7 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOc3ccccc3)ccc1-2 nan
CHEMBL3719036 134879 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 434 8 0 7 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOc3ccccc3)ccc1-2 nan
90242134 134881 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 452 6 0 9 3.3 CC(C)(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)no1 nan
CHEMBL3719047 134881 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 452 6 0 9 3.3 CC(C)(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)no1 nan
76684768 134883 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 460 6 1 10 1.8 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCc3nnn[nH]3)ccc1-2 nan
CHEMBL3719052 134883 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 460 6 1 10 1.8 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCc3nnn[nH]3)ccc1-2 nan
90242408 134887 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 470 5 0 9 3.2 COc1cncc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1 nan
CHEMBL3719065 134887 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 470 5 0 9 3.2 COc1cncc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1 nan
76685015 134905 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 464 9 0 8 3.5 COc1ccc(OCCOc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
CHEMBL3719113 134905 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 464 9 0 8 3.5 COc1ccc(OCCOc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
90241653 134942 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 507 4 1 8 3.3 CC(O)(C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O)c1ccccc1 nan
CHEMBL3719248 134942 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 507 4 1 8 3.3 CC(O)(C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O)c1ccccc1 nan
76684491 134954 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 435 6 1 8 1.5 NC(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3719276 134954 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 435 6 1 8 1.5 NC(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
76684579 134967 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 461 6 1 11 1.2 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3nnn[nH]3)ccc1-2 nan
CHEMBL3719334 134967 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 461 6 1 11 1.2 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3nnn[nH]3)ccc1-2 nan
90241586 134968 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 431 3 1 8 1.8 CC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3719339 134968 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 431 3 1 8 1.8 CC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90240936 133742 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 440 4 0 8 2.7 N#CCCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3715145 133742 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 440 4 0 8 2.7 N#CCCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90240635 133771 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 482 5 1 8 2.8 NC(=O)c1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1 nan
CHEMBL3715263 133771 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 482 5 1 8 2.8 NC(=O)c1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)c1 nan
90242118 133819 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 431 4 1 8 1.8 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCCO)ccc1-2 nan
CHEMBL3715466 133819 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 431 4 1 8 1.8 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCCO)ccc1-2 nan
90242136 133846 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 443 3 0 7 3.5 CC(C)(C)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3715561 133846 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 443 3 0 7 3.5 CC(C)(C)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90241450 133967 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 470 5 0 9 3.2 COc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
CHEMBL3715970 133967 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 470 5 0 9 3.2 COc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
90242112 134247 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 417 3 1 8 1.4 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCO)ccc1-2 nan
CHEMBL3716912 134247 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 417 3 1 8 1.4 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCO)ccc1-2 nan
76685021 134322 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 479 4 1 8 3.6 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3ccc4[nH]ncc4c3)ccc1-2 nan
CHEMBL3717155 134322 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 479 4 1 8 3.6 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3ccc4[nH]ncc4c3)ccc1-2 nan
90242324 134532 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 487 6 0 10 2.7 Cc1cc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)nn1C nan
CHEMBL3717888 134532 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 487 6 0 10 2.7 Cc1cc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)nn1C nan
90240696 134550 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 440 4 0 8 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3cccnc3)ccc1-2 nan
CHEMBL3717964 134550 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 440 4 0 8 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3cccnc3)ccc1-2 nan
90240228 134569 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 441 4 0 9 2.5 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3cncnc3)ccc1-2 nan
CHEMBL3718025 134569 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 441 4 0 9 2.5 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3cncnc3)ccc1-2 nan
90239905 134581 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 464 3 0 8 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#Cc3ccncc3)ccc1-2 nan
CHEMBL3718068 134581 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 464 3 0 8 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#Cc3ccncc3)ccc1-2 nan
90242578 134663 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 475 6 0 11 2.4 Cc1noc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)n1 nan
CHEMBL3718310 134663 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 475 6 0 11 2.4 Cc1noc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)n1 nan
90242205 134725 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 454 4 0 8 3.5 Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
CHEMBL3718542 134725 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 454 4 0 8 3.5 Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
76684770 134843 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 424 4 0 5 4.8 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(-c3ccc4ccccc4c3)ccc1-2 nan
CHEMBL3718872 134843 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 424 4 0 5 4.8 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(-c3ccc4ccccc4c3)ccc1-2 nan
76684899 134920 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 470 6 0 9 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3ccncc3)ccc1-2 nan
CHEMBL3719180 134920 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 470 6 0 9 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3ccncc3)ccc1-2 nan
90242797 134936 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 471 3 1 8 2.7 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CC3(O)CCCC3)ccc1-2 nan
CHEMBL3719234 134936 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 471 3 1 8 2.7 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CC3(O)CCCC3)ccc1-2 nan
10171 1811 None 20 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 nan
71616860 1811 None 20 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 nan
CHEMBL3716365 1811 None 20 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 nan
DB15346 1811 None 20 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 nan
71616756 133631 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 384 7 0 6 3.0 CCCCCc1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
CHEMBL3714783 133631 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 384 7 0 6 3.0 CCCCCc1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
89645705 133632 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 414 6 0 7 2.8 CC(C)(C)COCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3714785 133632 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 414 6 0 7 2.8 CC(C)(C)COCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645448 133635 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 412 8 0 7 2.8 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(OCCCC3CC3)ccc1-2 nan
CHEMBL3714806 133635 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 412 8 0 7 2.8 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(OCCCC3CC3)ccc1-2 nan
71616163 133662 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 380 3 0 6 2.3 CC(C)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3714904 133662 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 380 3 0 6 2.3 CC(C)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
71616645 133717 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 380 3 0 6 2.3 CC(C)C#Cc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3715064 133717 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 380 3 0 6 2.3 CC(C)C#Cc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71616646 133725 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 384 6 0 7 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(OCC3CC3)ccc1-2 nan
CHEMBL3715088 133725 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 384 6 0 7 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(OCC3CC3)ccc1-2 nan
71616040 133757 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 420 3 0 6 3.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CC3CCCCC3)ccc1-2 nan
CHEMBL3715192 133757 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 420 3 0 6 3.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CC3CCCCC3)ccc1-2 nan
71615922 133810 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 5 0 7 2.6 CC(C)(C)OCc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3715443 133810 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 5 0 7 2.6 CC(C)(C)OCc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
71616529 133876 None 0 Human Functional pIC50 = 11 11.0 36 2
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 nan
CHEMBL3715656 133876 None 0 Human Functional pIC50 = 11 11.0 36 2
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 nan
89645519 133924 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 398 7 0 7 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CC3)ccc1-2 nan
CHEMBL3715817 133924 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 398 7 0 7 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CC3)ccc1-2 nan
89645718 133950 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 382 6 0 6 2.6 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(CCC3CC3)ccc1-2 nan
CHEMBL3715907 133950 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 382 6 0 6 2.6 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(CCC3CC3)ccc1-2 nan
71617444 133956 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 394 3 0 6 2.7 CC(C)(C)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3715923 133956 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 394 3 0 6 2.7 CC(C)(C)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
71616284 133983 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 410 4 1 7 1.6 CC(C)C(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3716024 133983 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 410 4 1 7 1.6 CC(C)C(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645729 134009 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 6 0 8 1.3 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(OCC3COC3)ccc1-2 nan
CHEMBL3716123 134009 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 6 0 8 1.3 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(OCC3COC3)ccc1-2 nan
71616864 134024 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 414 7 1 7 2.2 CC(C)C(O)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3716159 134024 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 414 7 1 7 2.2 CC(C)C(O)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645780 134035 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 8 0 7 2.2 COCCCCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3716184 134035 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 8 0 7 2.2 COCCCCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645570 134065 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 447 8 1 7 3.3 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(CCCNc3ccccc3)ccc1-2 nan
CHEMBL3716280 134065 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 447 8 1 7 3.3 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(CCCNc3ccccc3)ccc1-2 nan
89645206 134114 None 0 Human Functional pIC50 = 11 11.0 50 2
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 419 6 0 7 2.4 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(CCc3ccccn3)ccc1-2 nan
CHEMBL3716446 134114 None 0 Human Functional pIC50 = 11 11.0 50 2
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 419 6 0 7 2.4 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(CCc3ccccn3)ccc1-2 nan
89645671 134136 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 426 7 0 7 3.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CCCC3)ccc1-2 nan
CHEMBL3716527 134136 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 426 7 0 7 3.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CCCC3)ccc1-2 nan
89645393 134137 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 8 0 7 2.9 COC(CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O)C(C)C nan
CHEMBL3716528 134137 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 8 0 7 2.9 COC(CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O)C(C)C nan
71616863 134146 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 413 7 1 7 3.1 CCC(C)(C)CNc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3716561 134146 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 413 7 1 7 3.1 CCC(C)(C)CNc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71615920 134189 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 451 6 0 9 2.3 COc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c(OC)n1 nan
CHEMBL3716722 134189 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 451 6 0 9 2.3 COc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c(OC)n1 nan
89645455 134192 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 474 5 0 8 3.3 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(-c3ccc(N4CCCCC4)nc3)ccc1-2 nan
CHEMBL3716728 134192 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 474 5 0 8 3.3 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(-c3ccc(N4CCCCC4)nc3)ccc1-2 nan
89645301 134206 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 412 6 0 7 2.7 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(COC3CCCC3)ccc1-2 nan
CHEMBL3716784 134206 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 412 6 0 7 2.7 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(COC3CCCC3)ccc1-2 nan
89645669 134237 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 6 0 8 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(OCC3CCCCO3)ccc1-2 nan
CHEMBL3716889 134237 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 6 0 8 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(OCC3CCCCO3)ccc1-2 nan
71616287 134264 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 457 6 1 7 2.4 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNCc3ccccc3)ccc1-2 nan
CHEMBL3716958 134264 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 457 6 1 7 2.4 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNCc3ccccc3)ccc1-2 nan
89645809 134302 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 416 8 0 8 2.1 CC(C)OCCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3717086 134302 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 416 8 0 8 2.1 CC(C)OCCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71616165 134336 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 471 6 0 7 2.7 CN(CC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O)Cc1ccccc1 nan
CHEMBL3717201 134336 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 471 6 0 7 2.7 CN(CC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O)Cc1ccccc1 nan
71616642 134390 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 412 6 0 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(COC3CCCC3)ccc1-2 nan
CHEMBL3717416 134390 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 412 6 0 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(COC3CCCC3)ccc1-2 nan
89645646 134452 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 426 6 0 7 3.1 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COC3CCCCC3)ccc1-2 nan
CHEMBL3717600 134452 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 426 6 0 7 3.1 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COC3CCCCC3)ccc1-2 nan
71616404 134462 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 410 5 1 7 1.8 CCCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3717641 134462 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 410 5 1 7 1.8 CCCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
71616526 134488 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 452 7 0 10 2.1 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 nan
CHEMBL3717743 134488 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 452 7 0 10 2.1 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 nan
71616641 134494 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 445 4 1 8 1.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CC(O)c3cccnc3)ccc1-2 nan
CHEMBL3717753 134494 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 445 4 1 8 1.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CC(O)c3cccnc3)ccc1-2 nan
89645829 134495 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 416 9 0 8 2.1 CCCOCCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3717755 134495 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 416 9 0 8 2.1 CCCOCCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645361 134505 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 6 0 8 2.1 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(OCC3CCOCC3)ccc1-2 nan
CHEMBL3717790 134505 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 6 0 8 2.1 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(OCC3CCOCC3)ccc1-2 nan
71616164 134506 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 394 5 0 6 2.8 CCCCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3717795 134506 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 394 5 0 6 2.8 CCCCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645310 134513 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 6 1 7 2.6 CC(C)(C)C(O)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3717809 134513 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 6 1 7 2.6 CC(C)(C)C(O)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71616166 134523 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 424 5 1 7 2.0 CC(C)CC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3717853 134523 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 424 5 1 7 2.0 CC(C)CC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
71617677 134535 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 435 6 0 8 2.7 CCOc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3717905 134535 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 435 6 0 8 2.7 CCOc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
71617676 134549 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 450 6 0 8 2.9 COc1ccc(OC)c(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1 nan
CHEMBL3717963 134549 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 450 6 0 8 2.9 COc1ccc(OC)c(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1 nan
71616288 134564 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 409 6 1 8 2.5 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(NCc3ccco3)ccc1-2 nan
CHEMBL3718005 134564 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 409 6 1 8 2.5 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(NCc3ccco3)ccc1-2 nan
71617562 134585 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 476 5 0 9 2.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(-c3ccc(N4CCOCC4)nc3)ccc1-2 nan
CHEMBL3718080 134585 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 476 5 0 9 2.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(-c3ccc(N4CCOCC4)nc3)ccc1-2 nan
89645684 134620 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 467 6 0 9 3.1 CC(C)(C)c1cnc(COc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)o1 nan
CHEMBL3718192 134620 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 467 6 0 9 3.1 CC(C)(C)c1cnc(COc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)o1 nan
71615925 134633 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 487 7 0 9 3.5 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ncc(-c4ccccc4)o3)ccc1-2 nan
CHEMBL3718244 134633 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 487 7 0 9 3.5 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ncc(-c4ccccc4)o3)ccc1-2 nan
71616036 134666 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 452 7 0 10 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 nan
CHEMBL3718331 134666 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 452 7 0 10 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 nan
89645572 134673 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 3 0 7 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#Cc3ccccn3)ccc1-2 nan
CHEMBL3718350 134673 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 3 0 7 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#Cc3ccccn3)ccc1-2 nan
71616039 134713 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 406 3 0 6 2.8 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CC3CCCC3)ccc1-2 nan
CHEMBL3718497 134713 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 406 3 0 6 2.8 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CC3CCCC3)ccc1-2 nan
71615924 134722 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 460 5 0 8 2.9 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(-c3ccc(N4CCCC4)nc3)ccc1-2 nan
CHEMBL3718528 134722 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 460 5 0 8 2.9 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(-c3ccc(N4CCCC4)nc3)ccc1-2 nan
89645532 134749 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 386 7 0 7 1.8 COCCCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3718618 134749 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 386 7 0 7 1.8 COCCCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645488 134789 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 382 6 0 6 2.6 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(CCC3CC3)ccc1-2 nan
CHEMBL3718720 134789 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 382 6 0 6 2.6 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(CCC3CC3)ccc1-2 nan
71617561 134865 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 435 6 0 8 2.7 CCOc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
CHEMBL3718999 134865 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 435 6 0 8 2.7 CCOc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
89645626 134896 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 8 1 7 2.7 CCC(O)(CC)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3719080 134896 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 8 1 7 2.7 CCC(O)(CC)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71617205 134899 None 1 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 nan
CHEMBL3719092 134899 None 1 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 nan
89645306 134901 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 7 0 7 2.2 COC(C)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3719100 134901 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 7 0 7 2.2 COC(C)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71616035 134902 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 440 7 0 10 1.8 CCc1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)no1 nan
CHEMBL3719101 134902 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 440 7 0 10 1.8 CCc1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)no1 nan
89645377 134913 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 426 6 1 7 2.5 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(CCC3(O)CCCC3)ccc1-2 nan
CHEMBL3719143 134913 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 426 6 1 7 2.5 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(CCC3(O)CCCC3)ccc1-2 nan
71617560 134947 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 449 6 0 8 3.1 CC(C)Oc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
CHEMBL3719258 134947 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 449 6 0 8 3.1 CC(C)Oc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
71598639 134976 None 23 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 421 6 0 8 2.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 nan
CHEMBL3719364 134976 None 23 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 421 6 0 8 2.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 nan
71616037 134978 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 454 7 0 10 2.3 CC(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)no1 nan
CHEMBL3719374 134978 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 454 7 0 10 2.3 CC(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)no1 nan
10171 1811 None 20 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 nan
71616860 1811 None 20 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 nan
CHEMBL3716365 1811 None 20 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 nan
DB15346 1811 None 20 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 nan
71616286 133653 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 458 4 1 7 2.5 CC(O)(C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O)c1ccccc1 nan
CHEMBL3714875 133653 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 458 4 1 7 2.5 CC(O)(C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O)c1ccccc1 nan
71616163 133662 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 380 3 0 6 2.3 CC(C)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3714904 133662 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 380 3 0 6 2.3 CC(C)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645754 133687 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 426 6 1 7 2.5 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(CCC3(O)CCCC3)ccc1-2 nan
CHEMBL3714986 133687 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 426 6 1 7 2.5 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(CCC3(O)CCCC3)ccc1-2 nan
89645653 133715 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 449 7 1 8 2.3 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(CCC(O)c3cccnc3)ccc1-2 nan
CHEMBL3715055 133715 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 449 7 1 8 2.3 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(CCC(O)c3cccnc3)ccc1-2 nan
71616645 133717 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 380 3 0 6 2.3 CC(C)C#Cc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3715064 133717 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 380 3 0 6 2.3 CC(C)C#Cc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71617203 133785 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 468 6 0 10 2.5 CC(C)(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)no1 nan
CHEMBL3715322 133785 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 468 6 0 10 2.5 CC(C)(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)no1 nan
71615922 133810 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 400 5 0 7 2.6 CC(C)(C)OCc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3715443 133810 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 400 5 0 7 2.6 CC(C)(C)OCc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645316 133831 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 380 4 0 6 2.4 CCCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3715514 133831 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 380 4 0 6 2.4 CCCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
71616529 133876 None 0 Human Functional pIC50 = 11 11.0 36 2
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 nan
CHEMBL3715656 133876 None 0 Human Functional pIC50 = 11 11.0 36 2
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 nan
89645442 133881 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 400 5 0 7 2.7 CC(C)(C)COc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3715679 133881 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 400 5 0 7 2.7 CC(C)(C)COc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645718 133950 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 382 6 0 6 2.6 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(CCC3CC3)ccc1-2 nan
CHEMBL3715907 133950 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 382 6 0 6 2.6 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(CCC3CC3)ccc1-2 nan
89645365 133955 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 442 7 0 8 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CCOCC3)ccc1-2 nan
CHEMBL3715918 133955 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 442 7 0 8 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CCOCC3)ccc1-2 nan
71617444 133956 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 394 3 0 6 2.7 CC(C)(C)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3715923 133956 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 394 3 0 6 2.7 CC(C)(C)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
71616284 133983 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 410 4 1 7 1.6 CC(C)C(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3716024 133983 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 410 4 1 7 1.6 CC(C)C(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645780 134035 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 400 8 0 7 2.2 COCCCCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3716184 134035 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 400 8 0 7 2.2 COCCCCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645570 134065 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 447 8 1 7 3.3 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(CCCNc3ccccc3)ccc1-2 nan
CHEMBL3716280 134065 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 447 8 1 7 3.3 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(CCCNc3ccccc3)ccc1-2 nan
89645206 134114 None 0 Human Functional pIC50 = 11 11.0 50 2
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 419 6 0 7 2.4 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(CCc3ccccn3)ccc1-2 nan
CHEMBL3716446 134114 None 0 Human Functional pIC50 = 11 11.0 50 2
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 419 6 0 7 2.4 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(CCc3ccccn3)ccc1-2 nan
89645671 134136 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 426 7 0 7 3.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CCCC3)ccc1-2 nan
CHEMBL3716527 134136 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 426 7 0 7 3.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CCCC3)ccc1-2 nan
71616863 134146 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 413 7 1 7 3.1 CCC(C)(C)CNc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3716561 134146 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 413 7 1 7 3.1 CCC(C)(C)CNc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645455 134192 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 474 5 0 8 3.3 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(-c3ccc(N4CCCCC4)nc3)ccc1-2 nan
CHEMBL3716728 134192 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 474 5 0 8 3.3 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(-c3ccc(N4CCCCC4)nc3)ccc1-2 nan
89645301 134206 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 412 6 0 7 2.7 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(COC3CCCC3)ccc1-2 nan
CHEMBL3716784 134206 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 412 6 0 7 2.7 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(COC3CCCC3)ccc1-2 nan
89645669 134237 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 428 6 0 8 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(OCC3CCCCO3)ccc1-2 nan
CHEMBL3716889 134237 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 428 6 0 8 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(OCC3CCCCO3)ccc1-2 nan
89645809 134302 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 416 8 0 8 2.1 CC(C)OCCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3717086 134302 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 416 8 0 8 2.1 CC(C)OCCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645506 134323 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 415 3 0 7 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#Cc3cccnc3)ccc1-2 nan
CHEMBL3717158 134323 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 415 3 0 7 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#Cc3cccnc3)ccc1-2 nan
71616165 134336 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 471 6 0 7 2.7 CN(CC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O)Cc1ccccc1 nan
CHEMBL3717201 134336 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 471 6 0 7 2.7 CN(CC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O)Cc1ccccc1 nan
71617672 134344 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 450 6 0 8 2.9 COc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1OC nan
CHEMBL3717251 134344 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 450 6 0 8 2.9 COc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1OC nan
71616644 134380 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 nan
CHEMBL3717363 134380 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 nan
89645546 134385 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 443 4 0 7 3.4 Cn1ccc2cc(-c3ccc4c(c3)CCn3c-4cc(OCC4COCCO4)nc3=O)ccc21 nan
CHEMBL3717390 134385 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 443 4 0 7 3.4 Cn1ccc2cc(-c3ccc4c(c3)CCn3c-4cc(OCC4COCCO4)nc3=O)ccc21 nan
71616642 134390 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 412 6 0 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(COC3CCCC3)ccc1-2 nan
CHEMBL3717416 134390 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 412 6 0 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(COC3CCCC3)ccc1-2 nan
71616168 134404 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 396 4 1 7 1.4 CCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3717453 134404 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 396 4 1 7 1.4 CCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
71616404 134462 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 410 5 1 7 1.8 CCCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3717641 134462 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 410 5 1 7 1.8 CCCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645829 134495 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 416 9 0 8 2.1 CCCOCCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3717755 134495 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 416 9 0 8 2.1 CCCOCCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645361 134505 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 428 6 0 8 2.1 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(OCC3CCOCC3)ccc1-2 nan
CHEMBL3717790 134505 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 428 6 0 8 2.1 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(OCC3CCOCC3)ccc1-2 nan
71617677 134535 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 435 6 0 8 2.7 CCOc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3717905 134535 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 435 6 0 8 2.7 CCOc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645745 134540 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 386 7 0 7 1.8 COCCCc1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
CHEMBL3717924 134540 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 386 7 0 7 1.8 COCCCc1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
71617562 134585 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 476 5 0 9 2.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(-c3ccc(N4CCOCC4)nc3)ccc1-2 nan
CHEMBL3718080 134585 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 476 5 0 9 2.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(-c3ccc(N4CCOCC4)nc3)ccc1-2 nan
89645443 134612 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 386 6 1 7 1.6 CC(O)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3718174 134612 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 386 6 1 7 1.6 CC(O)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645513 134648 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 429 4 1 6 3.4 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(-c3ccc4[nH]ccc4c3)ccc1-2 nan
CHEMBL3718280 134648 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 429 4 1 6 3.4 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(-c3ccc4[nH]ccc4c3)ccc1-2 nan
71616036 134666 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 452 7 0 10 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 nan
CHEMBL3718331 134666 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 452 7 0 10 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 nan
89645497 134788 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 400 7 1 7 2.0 CC(O)CCCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3718719 134788 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 400 7 1 7 2.0 CC(O)CCCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645488 134789 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 382 6 0 6 2.6 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(CCC3CC3)ccc1-2 nan
CHEMBL3718720 134789 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 382 6 0 6 2.6 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(CCC3CC3)ccc1-2 nan
89645319 134823 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 426 7 0 8 1.3 COCCOCC#Cc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3718818 134823 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 426 7 0 8 1.3 COCCOCC#Cc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71617205 134899 None 1 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 nan
CHEMBL3719092 134899 None 1 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 nan
71617560 134947 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 449 6 0 8 3.1 CC(C)Oc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
CHEMBL3719258 134947 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 449 6 0 8 3.1 CC(C)Oc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
71598639 134976 None 23 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 421 6 0 8 2.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 nan
CHEMBL3719364 134976 None 23 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 421 6 0 8 2.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 nan
71616037 134978 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 454 7 0 10 2.3 CC(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)no1 nan
CHEMBL3719374 134978 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 454 7 0 10 2.3 CC(C)c1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)no1 nan
90242131 133658 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 460 6 0 10 2.6 O=c1nc(OC[C@H]2COc3ncccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
CHEMBL3714891 133658 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 460 6 0 10 2.6 O=c1nc(OC[C@H]2COc3ncccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
76684759 133678 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 462 6 0 8 3.2 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCC3COc4ccccc4O3)ccc1-2 nan
CHEMBL3714958 133678 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 462 6 0 8 3.2 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCC3COc4ccccc4O3)ccc1-2 nan
76684682 133720 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 477 7 0 9 2.6 CC1(COCc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)COC1 nan
CHEMBL3715069 133720 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 477 7 0 9 2.6 CC1(COCc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)COC1 nan
90240137 133829 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 464 3 0 8 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#Cc3cccnc3)ccc1-2 nan
CHEMBL3715503 133829 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 464 3 0 8 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#Cc3cccnc3)ccc1-2 nan
76685019 133871 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 418 5 0 9 2.0 N#CCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3715646 133871 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 418 5 0 9 2.0 N#CCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242197 133887 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 445 3 1 8 2.2 CC(C)(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3715691 133887 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 445 3 1 8 2.2 CC(C)(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90241450 133967 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 470 5 0 9 3.2 COc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
CHEMBL3715970 133967 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 470 5 0 9 3.2 COc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
90242122 134133 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 431 4 0 8 2.1 COCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3716520 134133 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 431 4 0 8 2.1 COCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242227 134220 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 445 4 1 8 2.2 CCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3716828 134220 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 445 4 1 8 2.2 CCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
76684578 134252 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 470 6 0 9 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 nan
CHEMBL3716925 134252 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 470 6 0 9 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 nan
90239525 134312 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 464 4 0 8 3.6 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3717108 134312 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 464 4 0 8 3.6 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90253075 134364 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 506 8 0 10 1.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(COCCN3CCOCC3)ccc1-2 nan
CHEMBL3717323 134364 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 506 8 0 10 1.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(COCCN3CCOCC3)ccc1-2 nan
90242132 134472 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 460 6 0 10 2.6 O=c1nc(OC[C@@H]2COc3ncccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
CHEMBL3717676 134472 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 460 6 0 10 2.6 O=c1nc(OC[C@@H]2COc3ncccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
90242324 134532 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 487 6 0 10 2.7 Cc1cc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)nn1C nan
CHEMBL3717888 134532 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 487 6 0 10 2.7 Cc1cc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)nn1C nan
90239905 134581 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 464 3 0 8 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#Cc3ccncc3)ccc1-2 nan
CHEMBL3718068 134581 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 464 3 0 8 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#Cc3ccncc3)ccc1-2 nan
76684681 134634 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 449 6 0 9 2.0 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(COC3COC3)ccc1-2 nan
CHEMBL3718246 134634 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 449 6 0 9 2.0 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(COC3COC3)ccc1-2 nan
90242242 134685 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 449 7 0 8 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc([N+](=O)[O-])c3)ccc1-2 nan
CHEMBL3718388 134685 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 449 7 0 8 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc([N+](=O)[O-])c3)ccc1-2 nan
90242259 134709 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 429 4 1 8 2.5 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3cn[nH]c3)ccc1-2 nan
CHEMBL3718482 134709 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 429 4 1 8 2.5 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3cn[nH]c3)ccc1-2 nan
90242205 134725 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 454 4 0 8 3.5 Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
CHEMBL3718542 134725 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 454 4 0 8 3.5 Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)cn1 nan
76684490 134751 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 505 6 0 9 1.9 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)N1CCOCC1 nan
CHEMBL3718620 134751 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 505 6 0 9 1.9 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)N1CCOCC1 nan
90240938 134778 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 506 6 1 8 3.2 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCNCc3ccccc3)ccc1-2 nan
CHEMBL3718687 134778 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 506 6 1 8 3.2 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCNCc3ccccc3)ccc1-2 nan
90242357 134781 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 459 4 1 8 2.4 CC(C)C(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3718693 134781 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 459 4 1 8 2.4 CC(C)C(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242390 134821 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 459 5 1 8 2.6 CCCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3718814 134821 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 459 5 1 8 2.6 CCCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
76685017 134857 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 460 6 0 10 2.6 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
CHEMBL3718963 134857 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 460 6 0 10 2.6 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
90241703 134870 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 460 5 0 8 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(CN3CCCCC3)ccc1-2 nan
CHEMBL3719012 134870 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 460 5 0 8 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(CN3CCCCC3)ccc1-2 nan
76684663 134879 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 434 8 0 7 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOc3ccccc3)ccc1-2 nan
CHEMBL3719036 134879 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 434 8 0 7 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCOc3ccccc3)ccc1-2 nan
76684768 134883 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 460 6 1 10 1.8 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCc3nnn[nH]3)ccc1-2 nan
CHEMBL3719052 134883 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 460 6 1 10 1.8 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCc3nnn[nH]3)ccc1-2 nan
76684892 134898 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 489 6 0 8 2.7 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)N1CCCC1 nan
CHEMBL3719089 134898 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 489 6 0 8 2.7 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)N1CCCC1 nan
76684899 134920 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 470 6 0 9 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3ccncc3)ccc1-2 nan
CHEMBL3719180 134920 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 470 6 0 9 3.1 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3ccncc3)ccc1-2 nan
90242797 134936 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 471 3 1 8 2.7 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CC3(O)CCCC3)ccc1-2 nan
CHEMBL3719234 134936 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 471 3 1 8 2.7 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CC3(O)CCCC3)ccc1-2 nan
90241586 134968 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 431 3 1 8 1.8 CC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3719339 134968 None 0 Human Functional pIC50 = 11 11.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 431 3 1 8 1.8 CC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242190 134662 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 493 4 1 8 3.2 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CC(O)c3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c00272
CHEMBL3718309 134662 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 493 4 1 8 3.2 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CC(O)c3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c00272
71616529 133876 None 0 Human Functional pIC50 = 9.1 9.1 36 2
Antagonist activity at human Flag-tagged Gialpha-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at human Flag-tagged Gialpha-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3715656 133876 None 0 Human Functional pIC50 = 9.1 9.1 36 2
Antagonist activity at human Flag-tagged Gialpha-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at human Flag-tagged Gialpha-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
137636801 155894 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 464 3 0 8 2.9 O=c1cc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#Cc3ccncn3)ccc1-2 10.1021/acs.jmedchem.6b00935
CHEMBL4060589 155894 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 464 3 0 8 2.9 O=c1cc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#Cc3ccncn3)ccc1-2 10.1021/acs.jmedchem.6b00935
137634047 156642 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 486 6 0 9 3.3 Cc1cc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)cc2=O)nn1C 10.1021/acs.jmedchem.6b00935
CHEMBL4069275 156642 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 486 6 0 9 3.3 Cc1cc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)cc2=O)nn1C 10.1021/acs.jmedchem.6b00935
137652440 157530 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 440 4 0 8 3.1 O=c1cc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3cncnc3)ccc1-2 10.1021/acs.jmedchem.6b00935
CHEMBL4080004 157530 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 440 4 0 8 3.1 O=c1cc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3cncnc3)ccc1-2 10.1021/acs.jmedchem.6b00935
137647203 157750 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 481 5 1 7 3.5 NC(=O)c1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)cc2=O)c1 10.1021/acs.jmedchem.6b00935
CHEMBL4082477 157750 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 481 5 1 7 3.5 NC(=O)c1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)cc2=O)c1 10.1021/acs.jmedchem.6b00935
137648721 158019 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 439 4 0 7 3.7 O=c1cc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3cccnc3)ccc1-2 10.1021/acs.jmedchem.6b00935
CHEMBL4085616 158019 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 439 4 0 7 3.7 O=c1cc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3cccnc3)ccc1-2 10.1021/acs.jmedchem.6b00935
137643534 158426 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 430 4 1 7 2.4 O=c1cc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCCO)ccc1-2 10.1021/acs.jmedchem.6b00935
CHEMBL4090321 158426 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 430 4 1 7 2.4 O=c1cc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCCO)ccc1-2 10.1021/acs.jmedchem.6b00935
137661584 159142 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 474 6 0 10 3.0 Cc1noc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)cc2=O)n1 10.1021/acs.jmedchem.6b00935
CHEMBL4098028 159142 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 474 6 0 10 3.0 Cc1noc(COc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)cc2=O)n1 10.1021/acs.jmedchem.6b00935
137657193 159632 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 478 4 1 7 4.2 O=c1cc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3ccc4[nH]ncc4c3)ccc1-2 10.1021/acs.jmedchem.6b00935
CHEMBL4103552 159632 None 0 Human Functional pIC50 = 8 8.0 - 1
Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayAntagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assay
ChEMBL 478 4 1 7 4.2 O=c1cc(OCC2COc3ncccc3O2)cc2n1CCc1cc(-c3ccc4[nH]ncc4c3)ccc1-2 10.1021/acs.jmedchem.6b00935
168277163 190632 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 433 6 2 4 4.9 CC(=O)NCc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5181240 190632 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 433 6 2 4 4.9 CC(=O)NCc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
76684896 133634 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 489 7 0 8 3.6 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCCN3CCCCC3)ccc1-2 nan
CHEMBL3714804 133634 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 489 7 0 8 3.6 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCCN3CCCCC3)ccc1-2 nan
90242245 133637 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 491 8 0 8 2.9 CCN(CC)C(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3714809 133637 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 491 8 0 8 2.9 CCN(CC)C(=O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
90242297 133643 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 444 3 1 8 2.2 CC(C)(N)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3714820 133643 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 444 3 1 8 2.2 CC(C)(N)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242183 133645 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 388 3 0 8 2.0 N#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3714825 133645 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 388 3 0 8 2.0 N#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
76684668 133659 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 483 7 0 9 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc(-c4cncnc4)n3)ccc1-2 nan
CHEMBL3714897 133659 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 483 7 0 9 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc(-c4cncnc4)n3)ccc1-2 nan
76685020 133669 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 490 7 0 9 2.9 CN1CCCC1CCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3714922 133669 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 490 7 0 9 2.9 CN1CCCC1CCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
76684763 133677 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 422 6 0 6 3.7 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccc(F)cc3)ccc1-2 nan
CHEMBL3714952 133677 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 422 6 0 6 3.7 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccc(F)cc3)ccc1-2 nan
76684764 133724 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 7 0 8 3.4 COC(=O)c1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
CHEMBL3715086 133724 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 462 7 0 8 3.4 COC(=O)c1ccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
76684669 133737 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 436 7 0 10 1.9 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3nnnn3C3CC3)ccc1-2 nan
CHEMBL3715120 133737 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 436 7 0 10 1.9 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3nnnn3C3CC3)ccc1-2 nan
90242048 133769 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 446 5 0 8 2.7 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(CN3CCCC3)ccc1-2 nan
CHEMBL3715250 133769 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 446 5 0 8 2.7 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(CN3CCCC3)ccc1-2 nan
76684672 133795 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 404 5 0 6 3.7 COc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
CHEMBL3715368 133795 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 404 5 0 6 3.7 COc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
90242407 133840 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 484 3 1 8 3.1 NC1(C#Cc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)CCCCC1 nan
CHEMBL3715550 133840 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 484 3 1 8 3.1 NC1(C#Cc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)CCCCC1 nan
90242079 133867 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 534 4 0 10 1.2 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCN3CCS(=O)(=O)CC3)ccc1-2 nan
CHEMBL3715633 133867 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 534 4 0 10 1.2 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#CCN3CCS(=O)(=O)CC3)ccc1-2 nan
76684660 133916 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 7 0 6 3.6 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCc3ccccc3)ccc1-2 nan
CHEMBL3715772 133916 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 7 0 6 3.6 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCCc3ccccc3)ccc1-2 nan
90242088 133948 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 472 7 1 8 2.8 CCCCNCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3715903 133948 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 472 7 1 8 2.8 CCCCNCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242279 133996 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 404 5 0 6 3.7 COc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
CHEMBL3716060 133996 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 404 5 0 6 3.7 COc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
76684675 134034 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 417 5 1 6 2.8 NC(=O)c1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
CHEMBL3716183 134034 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 417 5 1 6 2.8 NC(=O)c1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
76684760 134059 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 6 0 7 3.5 N#Cc1cccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
CHEMBL3716270 134059 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 429 6 0 7 3.5 N#Cc1cccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
76684895 134082 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 475 7 0 8 3.2 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCCN3CCCC3)ccc1-2 nan
CHEMBL3716334 134082 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 475 7 0 8 3.2 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCCN3CCCC3)ccc1-2 nan
76684762 134115 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 438 6 0 6 4.3 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccccc3Cl)ccc1-2 nan
CHEMBL3716448 134115 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 438 6 0 6 4.3 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccccc3Cl)ccc1-2 nan
90240503 134205 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 503 8 0 8 3.9 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCCCN3CCCCC3)ccc1-2 nan
CHEMBL3716781 134205 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 503 8 0 8 3.9 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCCCN3CCCCC3)ccc1-2 nan
90242110 134210 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 438 8 0 10 2.0 CCCn1nnnc1COc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
CHEMBL3716807 134210 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 438 8 0 10 2.0 CCCn1nnnc1COc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
90253097 134234 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 6 0 7 3.3 C=CCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3716875 134234 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 6 0 7 3.3 C=CCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
76684572 134343 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 370 7 0 6 3.2 CCCCOc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
CHEMBL3717237 134343 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 370 7 0 6 3.2 CCCCOc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
76684891 134357 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 436 6 1 8 2.1 O=C(O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3717307 134357 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 436 6 1 8 2.1 O=C(O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
90242695 134373 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 499 4 1 9 1.0 O=C1CN(CC#Cc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)C(=O)N1 nan
CHEMBL3717345 134373 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 499 4 1 9 1.0 O=C1CN(CC#Cc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)C(=O)N1 nan
90242132 134472 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 460 6 0 10 2.6 O=c1nc(OC[C@@H]2COc3ncccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
CHEMBL3717676 134472 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 460 6 0 10 2.6 O=c1nc(OC[C@@H]2COc3ncccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
90253148 134556 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 490 5 1 9 2.0 O=C(NC1CCOCC1)c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3717979 134556 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 490 5 1 9 2.0 O=C(NC1CCOCC1)c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242347 134562 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 486 5 1 9 1.8 CCNC1(C#Cc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)COC1 nan
CHEMBL3717999 134562 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 486 5 1 9 1.8 CCNC1(C#Cc2ccc3c(c2)CCn2c-3cc(OCC3COc4ncccc4O3)nc2=O)COC1 nan
76684769 134563 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 459 6 0 9 3.3 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
CHEMBL3718000 134563 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 459 6 0 9 3.3 O=c1nc(OCC2COc3ccccc3O2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
90242067 134572 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 472 6 0 8 2.8 CCN(CC)CC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3718037 134572 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 472 6 0 8 2.8 CCN(CC)CC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242339 134593 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 492 7 0 10 1.8 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCCN3CCOCC3)ccc1-2 nan
CHEMBL3718109 134593 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 492 7 0 10 1.8 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCCN3CCOCC3)ccc1-2 nan
90241517 134618 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 489 7 0 8 3.5 CN1CCCC1CCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3718190 134618 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 489 7 0 8 3.5 CN1CCCC1CCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
76684569 134637 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 405 6 0 7 3.0 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccnc3)ccc1-2 nan
CHEMBL3718257 134637 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 405 6 0 7 3.0 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccnc3)ccc1-2 nan
76684674 134661 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 417 5 0 6 3.8 CN(C)c1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
CHEMBL3718308 134661 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 417 5 0 6 3.8 CN(C)c1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cc1 nan
76684571 134689 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 368 6 0 6 2.8 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCC3CC3)ccc1-2 nan
CHEMBL3718406 134689 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 368 6 0 6 2.8 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCC3CC3)ccc1-2 nan
76684666 134703 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 485 7 0 9 3.4 Cn1cc(-c2cccc(COc3ccc4c(c3)CCn3c-4cc(OCC4CCCO4)nc3=O)n2)cn1 nan
CHEMBL3718451 134703 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 485 7 0 9 3.4 Cn1cc(-c2cccc(COc3ccc4c(c3)CCn3c-4cc(OCC4CCCO4)nc3=O)n2)cn1 nan
90241668 134738 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 518 8 0 9 2.7 CN1CCN(CCCOc2ccc3c(c2)CCn2c-3cc(OCC3COc4ccccc4O3)nc2=O)CC1 nan
CHEMBL3718572 134738 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 518 8 0 9 2.7 CN1CCN(CCCOc2ccc3c(c2)CCn2c-3cc(OCC3COc4ccccc4O3)nc2=O)CC1 nan
76684581 134747 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 399 4 0 6 3.6 N#Cc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
CHEMBL3718615 134747 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 399 4 0 6 3.6 N#Cc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
90242241 134748 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 404 5 0 6 3.7 COc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
CHEMBL3718616 134748 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 404 5 0 6 3.7 COc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
90242125 134766 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 417 5 1 9 2.0 N#CCNc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3718644 134766 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 417 5 1 9 2.0 N#CCNc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
76684582 134770 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 374 4 0 5 3.7 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(-c3ccccc3)ccc1-2 nan
CHEMBL3718652 134770 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 374 4 0 5 3.7 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(-c3ccccc3)ccc1-2 nan
76684662 134806 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 405 6 0 7 3.0 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 nan
CHEMBL3718778 134806 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 405 6 0 7 3.0 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 nan
90242071 134867 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 520 6 0 8 3.6 CN(CC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O)Cc1ccccc1 nan
CHEMBL3719006 134867 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 520 6 0 8 3.6 CN(CC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O)Cc1ccccc1 nan
76684892 134898 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 489 6 0 8 2.7 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)N1CCCC1 nan
CHEMBL3719089 134898 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 489 6 0 8 2.7 O=C(COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)N1CCCC1 nan
76684661 134977 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 405 6 0 7 3.0 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccncc3)ccc1-2 nan
CHEMBL3719373 134977 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 405 6 0 7 3.0 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ccncc3)ccc1-2 nan
90240137 133829 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 464 3 0 8 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#Cc3cccnc3)ccc1-2 nan
CHEMBL3715503 133829 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 464 3 0 8 2.9 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(C#Cc3cccnc3)ccc1-2 nan
76684775 133912 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 405 5 0 7 3.1 COc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cn1 nan
CHEMBL3715761 133912 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 405 5 0 7 3.1 COc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)cn1 nan
90240249 133971 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 393 4 0 7 3.3 Cc1noc(C)c1-c1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
CHEMBL3715983 133971 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 393 4 0 7 3.3 Cc1noc(C)c1-c1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
90242122 134133 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 431 4 0 8 2.1 COCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3716520 134133 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 431 4 0 8 2.1 COCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90239525 134312 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 464 4 0 8 3.6 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3717108 134312 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 464 4 0 8 3.6 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90239807 134448 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 482 5 0 8 3.8 CN(C)c1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3717592 134448 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 482 5 0 8 3.8 CN(C)c1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90242403 134736 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 362 3 0 5 2.8 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 nan
CHEMBL3718569 134736 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 362 3 0 5 2.8 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 nan
76684901 134787 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 469 5 0 8 3.8 COc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3718718 134787 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 469 5 0 8 3.8 COc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
76685011 134953 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 418 6 0 6 3.9 Cc1cccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
CHEMBL3719274 134953 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 418 6 0 6 3.9 Cc1cccc(COc2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
71616971 134784 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 415 4 0 7 2.8 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3718710 134784 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 415 4 0 7 2.8 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
76684668 133659 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 483 7 0 9 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc(-c4cncnc4)n3)ccc1-2 nan
CHEMBL3714897 133659 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 483 7 0 9 3.5 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc(-c4cncnc4)n3)ccc1-2 nan
76684579 134967 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 461 6 1 11 1.2 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3nnn[nH]3)ccc1-2 nan
CHEMBL3719334 134967 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human human buffy coat neutrophils assessed as inhibition of cell migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 461 6 1 11 1.2 O=c1nc(OCC2COc3ncccc3O2)cc2n1CCc1cc(OCc3nnn[nH]3)ccc1-2 nan
168283101 191017 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 338 5 0 4 4.4 c1ccc(-c2nnc(CCc3cccnc3)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5186775 191017 None 0 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 338 5 0 4 4.4 c1ccc(-c2nnc(CCc3cccnc3)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
71616402 133638 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 450 7 0 8 3.2 CC(C)CCn1cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
CHEMBL3714813 133638 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 450 7 0 8 3.2 CC(C)CCn1cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
71617446 133646 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 3 0 7 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#Cc3ccncc3)ccc1-2 nan
CHEMBL3714827 133646 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 3 0 7 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#Cc3ccncc3)ccc1-2 nan
89645754 133687 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 426 6 1 7 2.5 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(CCC3(O)CCCC3)ccc1-2 nan
CHEMBL3714986 133687 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 426 6 1 7 2.5 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(CCC3(O)CCCC3)ccc1-2 nan
127024072 133698 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 471 4 1 7 2.0 CNC(=O)c1ccc(C#Cc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cc1 nan
CHEMBL3715009 133698 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 471 4 1 7 2.0 CNC(=O)c1ccc(C#Cc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cc1 nan
89645653 133715 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 449 7 1 8 2.3 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(CCC(O)c3cccnc3)ccc1-2 nan
CHEMBL3715055 133715 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 449 7 1 8 2.3 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(CCC(O)c3cccnc3)ccc1-2 nan
89645308 133722 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 414 6 0 7 1.6 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(C#CCOCCF)ccc1-2 nan
CHEMBL3715080 133722 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 414 6 0 7 1.6 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(C#CCOCCF)ccc1-2 nan
71617094 133729 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 418 3 0 8 1.4 Cn1cncc1C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3715095 133729 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 418 3 0 8 1.4 Cn1cncc1C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645726 133773 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 7 1 7 2.0 CCC(O)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3715265 133773 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 7 1 7 2.0 CCC(O)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71616968 133802 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 370 6 0 7 1.8 C=CCOc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3715404 133802 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 370 6 0 7 1.8 C=CCOc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645698 133814 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 369 5 0 8 1.2 N#CCOc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3715459 133814 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 369 5 0 8 1.2 N#CCOc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645638 133838 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 425 6 1 7 3.3 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(NCC3CCCCC3)ccc1-2 nan
CHEMBL3715540 133838 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 425 6 1 7 3.3 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(NCC3CCCCC3)ccc1-2 nan
71616403 133855 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 394 4 0 7 2.8 Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)o1 nan
CHEMBL3715594 133855 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 394 4 0 7 2.8 Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)o1 nan
89645442 133881 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 5 0 7 2.7 CC(C)(C)COc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3715679 133881 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 5 0 7 2.7 CC(C)(C)COc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645405 133886 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 386 7 1 7 1.6 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(CCCCO)ccc1-2 nan
CHEMBL3715690 133886 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 386 7 1 7 1.6 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(CCCCO)ccc1-2 nan
71616865 133940 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 441 10 1 7 3.9 CCCCC(CC)CNc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3715870 133940 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 441 10 1 7 3.9 CCCCC(CC)CNc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71617557 133942 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 314 3 0 6 1.3 O=c1nc(OCC2COCCO2)cc2n1CCc1ccccc1-2 nan
CHEMBL3715879 133942 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 314 3 0 6 1.3 O=c1nc(OCC2COCCO2)cc2n1CCc1ccccc1-2 nan
89645365 133955 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 442 7 0 8 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CCOCC3)ccc1-2 nan
CHEMBL3715918 133955 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 442 7 0 8 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CCOCC3)ccc1-2 nan
71616528 133992 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 338 3 0 6 1.2 C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3716050 133992 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 338 3 0 6 1.2 C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
127024075 134008 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 444 4 0 7 2.7 COc1cccc(C#Cc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1 nan
CHEMBL3716121 134008 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 444 4 0 7 2.7 COc1cccc(C#Cc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1 nan
89645197 134022 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 414 7 1 7 2.4 CC(C)(O)CCCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3716157 134022 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 414 7 1 7 2.4 CC(C)(O)CCCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71617443 134039 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 451 5 1 7 2.2 NC(=O)c1cc(F)cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1 nan
CHEMBL3716195 134039 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 451 5 1 7 2.2 NC(=O)c1cc(F)cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1 nan
89645383 134108 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 440 8 0 8 1.7 CCOCCOCC#Cc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3716433 134108 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 440 8 0 8 1.7 CCOCCOCC#Cc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645355 134162 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 7 0 7 3.5 CC(C)(C)CCCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3716619 134162 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 7 0 7 3.5 CC(C)(C)CCCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71616643 134229 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 424 5 0 7 2.3 COC(C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O)C(C)C nan
CHEMBL3716857 134229 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 424 5 0 7 2.3 COC(C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O)C(C)C nan
71617322 134236 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 451 5 1 7 2.2 NC(=O)c1ccc(F)c(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1 nan
CHEMBL3716882 134236 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 451 5 1 7 2.2 NC(=O)c1ccc(F)c(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1 nan
71616861 134284 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 6 0 8 1.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COC3COC3)ccc1-2 nan
CHEMBL3717016 134284 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 6 0 8 1.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COC3COC3)ccc1-2 nan
89645265 134319 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 411 5 1 7 3.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(NC3CCCCC3)ccc1-2 nan
CHEMBL3717133 134319 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 411 5 1 7 3.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(NC3CCCCC3)ccc1-2 nan
89645506 134323 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 3 0 7 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#Cc3cccnc3)ccc1-2 nan
CHEMBL3717158 134323 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 3 0 7 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#Cc3cccnc3)ccc1-2 nan
71617672 134344 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 450 6 0 8 2.9 COc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1OC nan
CHEMBL3717251 134344 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 450 6 0 8 2.9 COc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1OC nan
86717362 134354 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 416 9 0 8 2.1 CCCOCCOc1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
CHEMBL3717285 134354 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 416 9 0 8 2.1 CCCOCCOc1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
71616644 134380 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 nan
CHEMBL3717363 134380 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 nan
89645412 134389 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 382 3 1 7 1.0 CC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3717415 134389 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 382 3 1 7 1.0 CC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
71616168 134404 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 396 4 1 7 1.4 CCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3717453 134404 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 396 4 1 7 1.4 CCC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
71616757 134410 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 458 6 1 8 1.8 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNCc3cccnc3)ccc1-2 nan
CHEMBL3717471 134410 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 458 6 1 8 1.8 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNCc3cccnc3)ccc1-2 nan
71616407 134412 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 422 6 0 8 2.5 CCCn1cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
CHEMBL3717473 134412 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 422 6 0 8 2.5 CCCn1cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
71616752 134434 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 402 8 0 8 1.7 CCOCCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3717561 134434 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 402 8 0 8 1.7 CCOCCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71616524 134507 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 4 0 7 2.8 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3717796 134507 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 4 0 7 2.8 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645745 134540 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 386 7 0 7 1.8 COCCCc1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
CHEMBL3717924 134540 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 386 7 0 7 1.8 COCCCc1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
89645156 134551 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 4 0 7 2.8 N#Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cc1 nan
CHEMBL3717967 134551 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 4 0 7 2.8 N#Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cc1 nan
71616038 134559 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 426 6 0 10 1.5 Cc1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)no1 nan
CHEMBL3717983 134559 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 426 6 0 10 1.5 Cc1nc(COc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)no1 nan
71616973 134567 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 411 6 0 9 1.8 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
CHEMBL3718012 134567 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 411 6 0 9 1.8 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
71616285 134571 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 424 5 1 7 2.2 CCC(O)(C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O)CC nan
CHEMBL3718036 134571 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 424 5 1 7 2.2 CCC(O)(C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O)CC nan
71617448 134596 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 421 5 0 8 2.3 COc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3718113 134596 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 421 5 0 8 2.3 COc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645443 134612 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 386 6 1 7 1.6 CC(O)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3718174 134612 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 386 6 1 7 1.6 CC(O)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71617558 134652 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 396 4 0 7 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C3=CCOCC3)ccc1-2 nan
CHEMBL3718288 134652 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 396 4 0 7 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C3=CCOCC3)ccc1-2 nan
71616753 134653 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 370 6 0 7 1.8 C=CCOc1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
CHEMBL3718289 134653 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 370 6 0 7 1.8 C=CCOc1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
71617445 134655 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 425 6 0 9 2.1 Cc1cc(COc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)on1 nan
CHEMBL3718290 134655 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 425 6 0 9 2.1 Cc1cc(COc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)on1 nan
89645313 134667 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 418 4 0 8 1.5 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCn3ccnc3)ccc1-2 nan
CHEMBL3718332 134667 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 418 4 0 8 1.5 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCn3ccnc3)ccc1-2 nan
89645749 134687 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 6 1 7 2.0 CC(C)(O)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3718393 134687 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 6 1 7 2.0 CC(C)(O)CCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71616754 134691 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 370 6 0 7 1.8 C=CCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3718413 134691 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 370 6 0 7 1.8 C=CCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
86688463 134700 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 344 4 0 7 1.3 COc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3718436 134700 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 344 4 0 7 1.3 COc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
71616525 134776 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 4 0 7 2.8 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
CHEMBL3718680 134776 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 4 0 7 2.8 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
71616971 134784 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 4 0 7 2.8 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3718710 134784 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 4 0 7 2.8 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645497 134788 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 7 1 7 2.0 CC(O)CCCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3718719 134788 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 400 7 1 7 2.0 CC(O)CCCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71616974 134814 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 388 7 0 8 1.3 COCCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3718802 134814 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 388 7 0 8 1.3 COCCOc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645319 134823 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 426 7 0 8 1.3 COCCOCC#Cc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3718818 134823 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 426 7 0 8 1.3 COCCOCC#Cc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
71616755 134825 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 6 0 8 2.0 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(COC3CCOCC3)ccc1-2 nan
CHEMBL3718828 134825 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 6 0 8 2.0 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(COC3CCOCC3)ccc1-2 nan
71617675 134911 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 416 4 0 8 2.2 N#Cc1ccncc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3719137 134911 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 416 4 0 8 2.2 N#Cc1ccncc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
71617673 134972 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 455 5 0 8 3.0 COc1nccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1Cl nan
CHEMBL3719358 134972 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 455 5 0 8 3.0 COc1nccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1Cl nan
71616756 133631 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 384 7 0 6 3.0 CCCCCc1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
CHEMBL3714783 133631 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 384 7 0 6 3.0 CCCCCc1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
127024072 133698 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 471 4 1 7 2.0 CNC(=O)c1ccc(C#Cc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cc1 nan
CHEMBL3715009 133698 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 471 4 1 7 2.0 CNC(=O)c1ccc(C#Cc2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cc1 nan
71617094 133729 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 418 3 0 8 1.4 Cn1cncc1C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3715095 133729 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 418 3 0 8 1.4 Cn1cncc1C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645698 133814 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 369 5 0 8 1.2 N#CCOc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3715459 133814 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 369 5 0 8 1.2 N#CCOc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645270 133896 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 420 5 0 7 2.9 COc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3715719 133896 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 420 5 0 7 2.9 COc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645197 134022 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 414 7 1 7 2.4 CC(C)(O)CCCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
CHEMBL3716157 134022 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 414 7 1 7 2.4 CC(C)(O)CCCc1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O nan
89645507 134466 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 405 4 0 7 2.6 Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
CHEMBL3717653 134466 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 405 4 0 7 2.6 Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
71616973 134567 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 411 6 0 9 1.8 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
CHEMBL3718012 134567 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 411 6 0 9 1.8 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
71617448 134596 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 421 5 0 8 2.3 COc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
CHEMBL3718113 134596 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 421 5 0 8 2.3 COc1ncccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O nan
89645572 134673 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 415 3 0 7 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#Cc3ccccn3)ccc1-2 nan
CHEMBL3718350 134673 None 0 Human Functional pIC50 = 7 7.0 - 1
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assayAntagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL 415 3 0 7 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#Cc3ccccn3)ccc1-2 nan
12918236 193047 None 2 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 350 4 1 3 5.6 O=P(O)(Oc1ccc2ccccc2c1)Oc1ccc2ccccc2c1 10.1021/acs.jmedchem.1c01813
CHEMBL5207708 193047 None 2 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 350 4 1 3 5.6 O=P(O)(Oc1ccc2ccccc2c1)Oc1ccc2ccccc2c1 10.1021/acs.jmedchem.1c01813
CHEMBL5222969 193047 None 2 Human Functional pIC50 = 5 5.0 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 350 4 1 3 5.6 O=P(O)(Oc1ccc2ccccc2c1)Oc1ccc2ccccc2c1 10.1021/acs.jmedchem.1c01813
71616644 134380 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 10.1021/acs.jmedchem.0c00272
CHEMBL3717363 134380 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 10.1021/acs.jmedchem.0c00272
168277748 190272 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 406 5 2 4 5.0 O=C(O)c1cccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)c1 10.1021/acs.jmedchem.2c00804
CHEMBL5175634 190272 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 406 5 2 4 5.0 O=C(O)c1cccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)c1 10.1021/acs.jmedchem.2c00804
168287456 191506 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 286 3 1 3 3.6 c1ccc(-c2cnnc(Cc3c[nH]c4ccccc34)n2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5193872 191506 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 286 3 1 3 3.6 c1ccc(-c2cnnc(Cc3c[nH]c4ccccc34)n2)cc1 10.1021/acs.jmedchem.2c00804
153309768 192828 None 0 Human Functional pIC50 = 7.0 7.0 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP productionAntagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP production
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5179395 192828 None 0 Human Functional pIC50 = 7.0 7.0 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP productionAntagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP production
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221639 192828 None 0 Human Functional pIC50 = 7.0 7.0 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP productionAntagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP production
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
71616167 179776 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 354 4 0 6 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C3CC3)ccc1-2 10.1021/acs.jmedchem.0c00272
CHEMBL4744625 179776 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 354 4 0 6 2.1 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C3CC3)ccc1-2 10.1021/acs.jmedchem.0c00272
168283580 191230 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 327 4 1 4 3.8 Cc1cc(Cc2nnc(-c3ccccc3)c(-c3ccccc3)n2)n[nH]1 10.1021/acs.jmedchem.2c00804
CHEMBL5189932 191230 None 0 Human Functional pIC50 = 5.0 5.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 327 4 1 4 3.8 Cc1cc(Cc2nnc(-c3ccccc3)c(-c3ccccc3)n2)n[nH]1 10.1021/acs.jmedchem.2c00804
162642975 181651 None 0 Human Functional pIC50 = 8.0 8.0 67 2
Antagonist activity at recombinant human GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in capric acid-induced IP1 accumulation treated for 30 mins prior to capric acid stimulation measured after 1 hr by HTRF based immunoassayAntagonist activity at recombinant human GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in capric acid-induced IP1 accumulation treated for 30 mins prior to capric acid stimulation measured after 1 hr by HTRF based immunoassay
ChEMBL 395 7 0 8 2.3 COc1cc2c(cc1OC)-c1cc(OCCOc3ccccn3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
CHEMBL4776061 181651 None 0 Human Functional pIC50 = 8.0 8.0 67 2
Antagonist activity at recombinant human GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in capric acid-induced IP1 accumulation treated for 30 mins prior to capric acid stimulation measured after 1 hr by HTRF based immunoassayAntagonist activity at recombinant human GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in capric acid-induced IP1 accumulation treated for 30 mins prior to capric acid stimulation measured after 1 hr by HTRF based immunoassay
ChEMBL 395 7 0 8 2.3 COc1cc2c(cc1OC)-c1cc(OCCOc3ccccn3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
147422825 193030 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 478 4 1 3 7.3 O=P(O)(OC1=Cc2ccccc2Cc2ccccc21)OC1=Cc2ccccc2Cc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5206571 193030 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 478 4 1 3 7.3 O=P(O)(OC1=Cc2ccccc2Cc2ccccc21)OC1=Cc2ccccc2Cc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222874 193030 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 478 4 1 3 7.3 O=P(O)(OC1=Cc2ccccc2Cc2ccccc21)OC1=Cc2ccccc2Cc2ccccc21 10.1021/acs.jmedchem.1c01813
163321284 190612 None 5 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 422 6 1 5 5.3 COc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccc(OC)cc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5180892 190612 None 5 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 422 6 1 5 5.3 COc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccc(OC)cc2)cc1 10.1021/acs.jmedchem.2c00804
10171 1811 None 20 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
71616860 1811 None 20 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
CHEMBL3716365 1811 None 20 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
DB15346 1811 None 20 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
168274895 190214 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 488 5 1 5 4.7 CN1CCN(C(=O)c2ccc(-c3nnc(Cc4c[nH]c5ccccc45)nc3-c3ccccc3)cc2)CC1 10.1021/acs.jmedchem.2c00804
CHEMBL5174701 190214 None 0 Human Functional pIC50 = 6.0 6.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 488 5 1 5 4.7 CN1CCN(C(=O)c2ccc(-c3nnc(Cc4c[nH]c5ccccc45)nc3-c3ccccc3)cc2)CC1 10.1021/acs.jmedchem.2c00804
153309805 192927 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2ccc(Cl)cc2Sc2ccccc21)OC1=Cc2ccc(Cl)cc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5196560 192927 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2ccc(Cl)cc2Sc2ccccc21)OC1=Cc2ccc(Cl)cc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222262 192927 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2ccc(Cl)cc2Sc2ccccc21)OC1=Cc2ccc(Cl)cc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
168292024 192012 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 1 5 5.1 COC(=O)c1cccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)c1 10.1021/acs.jmedchem.2c00804
CHEMBL5201724 192012 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 1 5 5.1 COC(=O)c1cccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)c1 10.1021/acs.jmedchem.2c00804
162672502 183102 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 352 4 0 5 3.2 COc1ccc2c(c1)CCn1c-2cc(OCc2ccccc2F)nc1=O 10.1021/acs.jmedchem.0c00272
CHEMBL4794623 183102 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 352 4 0 5 3.2 COc1ccc2c(c1)CCn1c-2cc(OCc2ccccc2F)nc1=O 10.1021/acs.jmedchem.0c00272
168272510 190232 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 433 6 2 4 4.9 CC(=O)NCc1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5174990 190232 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 433 6 2 4 4.9 CC(=O)NCc1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
149469204 192014 None 0 Human Functional pIC50 = 6.9 6.9 4 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 3-OH-C12 induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 3-OH-C12 induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 514 4 1 5 8.4 O=P(O)(OC1=Cc2ccccc2Sc2ccccc21)OC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5194984 192014 None 0 Human Functional pIC50 = 6.9 6.9 4 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 3-OH-C12 induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 3-OH-C12 induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 514 4 1 5 8.4 O=P(O)(OC1=Cc2ccccc2Sc2ccccc21)OC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5201755 192014 None 0 Human Functional pIC50 = 6.9 6.9 4 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 3-OH-C12 induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 3-OH-C12 induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 514 4 1 5 8.4 O=P(O)(OC1=Cc2ccccc2Sc2ccccc21)OC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
168277450 190510 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 440 6 1 5 5.4 COc1ccc(-c2nnc(Cc3c[nH]c4ccc(F)cc34)nc2-c2ccc(OC)cc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5179431 190510 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 440 6 1 5 5.4 COc1ccc(-c2nnc(Cc3c[nH]c4ccc(F)cc34)nc2-c2ccc(OC)cc2)cc1 10.1021/acs.jmedchem.2c00804
168286683 191605 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 363 4 1 4 4.7 c1ccc(-c2nnc(Cc3c[nH]c4ncccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5195409 191605 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 363 4 1 4 4.7 c1ccc(-c2nnc(Cc3c[nH]c4ncccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168271529 190127 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 365 4 1 6 3.5 c1ccc(-c2nc(Cc3c[nH]c4cnccc34)nnc2-c2cnccn2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5173395 190127 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 365 4 1 6 3.5 c1ccc(-c2nc(Cc3c[nH]c4cnccc34)nnc2-c2cnccn2)cc1 10.1021/acs.jmedchem.2c00804
71616529 133876 None 0 Mouse Functional pIC50 = 6.9 6.9 -36 2
Antagonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3715656 133876 None 0 Mouse Functional pIC50 = 6.9 6.9 -36 2
Antagonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
71616529 133876 None 0 Human Functional pIC50 = 7.9 7.9 36 2
Antagonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3715656 133876 None 0 Human Functional pIC50 = 7.9 7.9 36 2
Antagonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
71616526 134488 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of embelin-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of embelin-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 452 7 0 10 2.1 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3717743 134488 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of embelin-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of embelin-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 452 7 0 10 2.1 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 10.1021/acs.jmedchem.0c01378
168271726 190410 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 364 4 1 5 4.1 c1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2cccnn2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5177839 190410 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 364 4 1 5 4.1 c1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2cccnn2)cc1 10.1021/acs.jmedchem.2c00804
168275049 190418 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 450 7 3 6 3.4 O=C(NCCO)c1ccc(-c2nc(Cc3c[nH]c4cnccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5177947 190418 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 450 7 3 6 3.4 O=C(NCCO)c1ccc(-c2nc(Cc3c[nH]c4cnccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168296983 192302 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 365 4 1 6 3.5 c1ccc(-c2nnc(Cc3c[nH]c4cnccc34)nc2-c2ccnnc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5206204 192302 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 365 4 1 6 3.5 c1ccc(-c2nnc(Cc3c[nH]c4cnccc34)nc2-c2ccnnc2)cc1 10.1021/acs.jmedchem.2c00804
71616529 133876 None 0 Mouse Functional pIC50 = 6.8 6.8 -36 2
Antagonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3715656 133876 None 0 Mouse Functional pIC50 = 6.8 6.8 -36 2
Antagonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
146842444 192976 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 482 4 1 5 7.7 O=P(O)(OC1=Cc2ccccc2Oc2ccccc21)OC1=Cc2ccccc2Oc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5189167 192976 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 482 4 1 5 7.7 O=P(O)(OC1=Cc2ccccc2Oc2ccccc21)OC1=Cc2ccccc2Oc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222551 192976 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 482 4 1 5 7.7 O=P(O)(OC1=Cc2ccccc2Oc2ccccc21)OC1=Cc2ccccc2Oc2ccccc21 10.1021/acs.jmedchem.1c01813
168294481 192195 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 398 4 1 3 5.6 Fc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5204521 192195 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 398 4 1 3 5.6 Fc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.2c00804
162656514 180914 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 364 6 0 6 2.9 COc1ccc2c(c1)CCn1c-2cc(OCCOc2ccccc2)nc1=O 10.1021/acs.jmedchem.0c00272
CHEMBL4757870 180914 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 364 6 0 6 2.9 COc1ccc2c(c1)CCn1c-2cc(OCCOc2ccccc2)nc1=O 10.1021/acs.jmedchem.0c00272
1782609 183196 None 10 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 364 5 0 6 3.1 COc1cc2c(cc1OC)-c1cc(OCc3ccccc3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
CHEMBL4795786 183196 None 10 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 364 5 0 6 3.1 COc1cc2c(cc1OC)-c1cc(OCc3ccccc3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
153309828 192854 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 450 4 1 3 7.9 O=P(O)(Oc1cc2ccccc2c2ccccc12)Oc1cc2ccccc2c2ccccc12 10.1021/acs.jmedchem.1c01813
CHEMBL5188961 192854 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 450 4 1 3 7.9 O=P(O)(Oc1cc2ccccc2c2ccccc12)Oc1cc2ccccc2c2ccccc12 10.1021/acs.jmedchem.1c01813
CHEMBL5221836 192854 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 450 4 1 3 7.9 O=P(O)(Oc1cc2ccccc2c2ccccc12)Oc1cc2ccccc2c2ccccc12 10.1021/acs.jmedchem.1c01813
168297446 192366 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 462 7 3 5 3.5 NC(=O)CNC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5207339 192366 None 0 Human Functional pIC50 = 5.8 5.8 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 462 7 3 5 3.5 NC(=O)CNC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168278894 190997 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 363 4 1 4 4.7 c1ccc(-c2nnc(Cc3c[nH]c4ccncc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5186601 190997 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 363 4 1 4 4.7 c1ccc(-c2nnc(Cc3c[nH]c4ccncc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
153309803 192994 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2ccccc2Sc2ccc(F)cc21)OC1=Cc2ccccc2Sc2ccc(F)cc21 10.1021/acs.jmedchem.1c01813
CHEMBL5203023 192994 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2ccccc2Sc2ccc(F)cc21)OC1=Cc2ccccc2Sc2ccc(F)cc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222655 192994 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2ccccc2Sc2ccc(F)cc21)OC1=Cc2ccccc2Sc2ccc(F)cc21 10.1021/acs.jmedchem.1c01813
89645365 133955 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of decanoic acid-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of decanoic acid-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 442 7 0 8 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CCOCC3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3715918 133955 None 0 Human Functional pIC50 = 6.8 6.8 - 1
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of decanoic acid-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of decanoic acid-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 442 7 0 8 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CCOCC3)ccc1-2 10.1021/acs.jmedchem.0c01378
168289426 191328 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 392 5 2 4 4.8 OCc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5191540 191328 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 392 5 2 4 4.8 OCc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
153309791 192923 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 634 8 1 9 8.5 COc1ccc2c(c1)Sc1c(OC)cccc1C(OP(=O)(O)OC1=Cc3ccc(OC)cc3Sc3c(OC)cccc31)=C2 10.1021/acs.jmedchem.1c01813
CHEMBL5197375 192923 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 634 8 1 9 8.5 COc1ccc2c(c1)Sc1c(OC)cccc1C(OP(=O)(O)OC1=Cc3ccc(OC)cc3Sc3c(OC)cccc31)=C2 10.1021/acs.jmedchem.1c01813
CHEMBL5222239 192923 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 634 8 1 9 8.5 COc1ccc2c(c1)Sc1c(OC)cccc1C(OP(=O)(O)OC1=Cc3ccc(OC)cc3Sc3c(OC)cccc31)=C2 10.1021/acs.jmedchem.1c01813
168286764 191679 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 1 5 5.1 COC(=O)c1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5196547 191679 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 1 5 5.1 COC(=O)c1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168288253 191306 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 430 4 1 3 6.6 Clc1ccccc1-c1nnc(Cc2c[nH]c3ccccc23)nc1-c1ccccc1Cl 10.1021/acs.jmedchem.2c00804
CHEMBL5191278 191306 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 430 4 1 3 6.6 Clc1ccccc1-c1nnc(Cc2c[nH]c3ccccc23)nc1-c1ccccc1Cl 10.1021/acs.jmedchem.2c00804
153309826 192869 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 610 6 1 7 8.7 COc1cccc2c1Sc1ccc(F)cc1C=C2OP(=O)(O)OC1=Cc2cc(F)ccc2Sc2c(OC)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5190809 192869 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 610 6 1 7 8.7 COc1cccc2c1Sc1ccc(F)cc1C=C2OP(=O)(O)OC1=Cc2cc(F)ccc2Sc2c(OC)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221914 192869 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 610 6 1 7 8.7 COc1cccc2c1Sc1ccc(F)cc1C=C2OP(=O)(O)OC1=Cc2cc(F)ccc2Sc2c(OC)cccc21 10.1021/acs.jmedchem.1c01813
168274255 190499 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 469 7 2 5 4.3 CS(=O)(=O)NCc1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5179309 190499 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 469 7 2 5 4.3 CS(=O)(=O)NCc1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
153309853 189921 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 510 4 1 3 8.7 O=P(O)(CC1=Cc2ccccc2Sc2ccccc21)CC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5169963 189921 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 510 4 1 3 8.7 O=P(O)(CC1=Cc2ccccc2Sc2ccccc21)CC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
162672947 183202 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 322 3 0 4 3.2 O=c1nc(OCc2ccccc2F)cc2n1CCc1ccccc1-2 10.1021/acs.jmedchem.0c00272
CHEMBL4795874 183202 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 322 3 0 4 3.2 O=c1nc(OCc2ccccc2F)cc2n1CCc1ccccc1-2 10.1021/acs.jmedchem.0c00272
168276448 190136 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 364 4 1 5 4.1 c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccn2)nc1 10.1021/acs.jmedchem.2c00804
CHEMBL5173507 190136 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 364 4 1 5 4.1 c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccn2)nc1 10.1021/acs.jmedchem.2c00804
168275915 190470 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 364 4 1 5 4.1 c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2cccnn2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5178841 190470 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 364 4 1 5 4.1 c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2cccnn2)cc1 10.1021/acs.jmedchem.2c00804
168289877 191373 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 463 8 2 5 4.7 COCCNC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5192235 191373 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 463 8 2 5 4.7 COCCNC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168289213 191509 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 502 5 1 5 4.2 CN1CCN(C(=O)c2ccc(-c3nnc(Cc4c[nH]c5ccccc45)nc3-c3ccccc3)cc2)CC1=O 10.1021/acs.jmedchem.2c00804
CHEMBL5193904 191509 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 502 5 1 5 4.2 CN1CCN(C(=O)c2ccc(-c3nnc(Cc4c[nH]c5ccccc45)nc3-c3ccccc3)cc2)CC1=O 10.1021/acs.jmedchem.2c00804
168283011 190872 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 419 6 1 4 5.3 CN(C)Cc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5184825 190872 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 419 6 1 4 5.3 CN(C)Cc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
1785231 180263 None 10 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 358 8 0 6 3.4 CCCCCCOc1cc2n(c(=O)n1)CCc1cc(OC)c(OC)cc1-2 10.1021/acs.jmedchem.0c00272
CHEMBL4750532 180263 None 10 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 358 8 0 6 3.4 CCCCCCOc1cc2n(c(=O)n1)CCc1cc(OC)c(OC)cc1-2 10.1021/acs.jmedchem.0c00272
71616529 133876 None 0 Human Functional pIC50 = 7.7 7.7 36 2
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of DIM-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of DIM-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3715656 133876 None 0 Human Functional pIC50 = 7.7 7.7 36 2
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of DIM-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of DIM-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
71616971 134784 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 415 4 0 7 2.8 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O 10.1021/acs.jmedchem.0c00272
CHEMBL3718710 134784 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 415 4 0 7 2.8 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O 10.1021/acs.jmedchem.0c00272
168274538 190288 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 478 6 1 7 4.9 COC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccc(C(=O)OC)cc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5175765 190288 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 478 6 1 7 4.9 COC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccc(C(=O)OC)cc2)cc1 10.1021/acs.jmedchem.2c00804
168277900 190668 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 423 6 1 6 4.7 COc1ccc(-c2nnc(Cc3n[nH]c4ccccc34)nc2-c2ccc(OC)cc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5181719 190668 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 423 6 1 6 4.7 COc1ccc(-c2nnc(Cc3n[nH]c4ccccc34)nc2-c2ccc(OC)cc2)cc1 10.1021/acs.jmedchem.2c00804
71616165 134336 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 471 6 0 7 2.7 CN(CC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O)Cc1ccccc1 10.1021/acs.jmedchem.0c00272
CHEMBL3717201 134336 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 471 6 0 7 2.7 CN(CC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O)Cc1ccccc1 10.1021/acs.jmedchem.0c00272
162656095 180724 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 393 4 0 8 2.1 COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O 10.1021/acs.jmedchem.0c00272
CHEMBL4755764 180724 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 393 4 0 8 2.1 COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O 10.1021/acs.jmedchem.0c00272
71616529 133876 None 0 Human Functional pIC50 = 7.7 7.7 36 2
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of embelin-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of embelin-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3715656 133876 None 0 Human Functional pIC50 = 7.7 7.7 36 2
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of embelin-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of embelin-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
156542972 192776 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 502 4 1 3 8.5 O=P(O)(O/C1=C/c2ccccc2/C=C\c2ccccc21)O/C1=C/c2ccccc2/C=C\c2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5179740 192776 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 502 4 1 3 8.5 O=P(O)(O/C1=C/c2ccccc2/C=C\c2ccccc21)O/C1=C/c2ccccc2/C=C\c2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221312 192776 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 502 4 1 3 8.5 O=P(O)(O/C1=C/c2ccccc2/C=C\c2ccccc21)O/C1=C/c2ccccc2/C=C\c2ccccc21 10.1021/acs.jmedchem.1c01813
168272726 190491 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 380 4 1 3 5.4 Fc1ccc2c(Cc3nnc(-c4ccccc4)c(-c4ccccc4)n3)c[nH]c2c1 10.1021/acs.jmedchem.2c00804
CHEMBL5179128 190491 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 380 4 1 3 5.4 Fc1ccc2c(Cc3nnc(-c4ccccc4)c(-c4ccccc4)n3)c[nH]c2c1 10.1021/acs.jmedchem.2c00804
168292424 192045 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 2 5 4.0 CNC(=O)c1ccc(-c2nc(Cc3c[nH]c4ccncc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5202315 192045 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 2 5 4.0 CNC(=O)c1ccc(-c2nc(Cc3c[nH]c4ccncc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168279722 191152 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 374 4 1 5 5.4 c1csc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2cccs2)c1 10.1021/acs.jmedchem.2c00804
CHEMBL5188586 191152 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 374 4 1 5 5.4 c1csc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2cccs2)c1 10.1021/acs.jmedchem.2c00804
153309772 192874 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2ccccc2Sc2cc(F)ccc21)OC1=Cc2ccccc2Sc2cc(F)ccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5190004 192874 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2ccccc2Sc2cc(F)ccc21)OC1=Cc2ccccc2Sc2cc(F)ccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221939 192874 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2ccccc2Sc2cc(F)ccc21)OC1=Cc2ccccc2Sc2cc(F)ccc21 10.1021/acs.jmedchem.1c01813
168282518 190822 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 469 7 2 5 4.3 CS(=O)(=O)NCc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5183982 190822 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 469 7 2 5 4.3 CS(=O)(=O)NCc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
71616166 134523 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 424 5 1 7 2.0 CC(C)CC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O 10.1021/acs.jmedchem.0c00272
CHEMBL3717853 134523 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 424 5 1 7 2.0 CC(C)CC(O)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O 10.1021/acs.jmedchem.0c00272
71616529 133876 None 0 Human Functional pIC50 = 7.6 7.6 36 2
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of decanoic acid-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of decanoic acid-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3715656 133876 None 0 Human Functional pIC50 = 7.6 7.6 36 2
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of decanoic acid-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of decanoic acid-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
168297380 192303 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 518 4 1 3 6.8 Brc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccc(Br)cc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5206221 192303 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 518 4 1 3 6.8 Brc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccc(Br)cc2)cc1 10.1021/acs.jmedchem.2c00804
153027899 192992 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 574 6 1 7 8.5 COc1ccc2c(c1)Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2cc(OC)ccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5202207 192992 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 574 6 1 7 8.5 COc1ccc2c(c1)Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2cc(OC)ccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222633 192992 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 574 6 1 7 8.5 COc1ccc2c(c1)Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2cc(OC)ccc21 10.1021/acs.jmedchem.1c01813
162677233 183492 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 382 5 0 6 3.2 COc1cc2c(cc1OC)-c1cc(OCc3ccccc3F)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
CHEMBL4799579 183492 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 382 5 0 6 3.2 COc1cc2c(cc1OC)-c1cc(OCc3ccccc3F)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
168270713 189927 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 370 4 1 4 4.5 FC(F)(F)Oc1ccccc1-c1cnc(Cc2c[nH]c3ccccc23)nn1 10.1021/acs.jmedchem.2c00804
CHEMBL5170018 189927 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 370 4 1 4 4.5 FC(F)(F)Oc1ccccc1-c1cnc(Cc2c[nH]c3ccccc23)nn1 10.1021/acs.jmedchem.2c00804
71616642 134390 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 412 6 0 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(COC3CCCC3)ccc1-2 10.1021/acs.jmedchem.0c00272
CHEMBL3717416 134390 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 412 6 0 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(COC3CCCC3)ccc1-2 10.1021/acs.jmedchem.0c00272
153309743 192758 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2c(F)cccc2Sc2ccccc21)OC1=Cc2c(F)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5170437 192758 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2c(F)cccc2Sc2ccccc21)OC1=Cc2c(F)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221157 192758 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2c(F)cccc2Sc2ccccc21)OC1=Cc2c(F)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
71598639 134976 None 23 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in 6-OAU induced intracellular cAMP production pretreated for 15 mins followed by forskolin and agonist addition and measured after 30 mins by HitHunter luminescence based microplate reader assayAntagonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in 6-OAU induced intracellular cAMP production pretreated for 15 mins followed by forskolin and agonist addition and measured after 30 mins by HitHunter luminescence based microplate reader assay
ChEMBL 421 6 0 8 2.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 10.1021/acs.jmedchem.1c01813
CHEMBL3719364 134976 None 23 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in 6-OAU induced intracellular cAMP production pretreated for 15 mins followed by forskolin and agonist addition and measured after 30 mins by HitHunter luminescence based microplate reader assayAntagonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in 6-OAU induced intracellular cAMP production pretreated for 15 mins followed by forskolin and agonist addition and measured after 30 mins by HitHunter luminescence based microplate reader assay
ChEMBL 421 6 0 8 2.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 10.1021/acs.jmedchem.1c01813
71598639 134976 None 23 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in 6-OAU-induced inhibition of forskolin stimulated cAMP production preincubated for 15 mins followed by forskolin and 6-OAU stimulation and measured after 30 mins by luminescence methodAntagonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in 6-OAU-induced inhibition of forskolin stimulated cAMP production preincubated for 15 mins followed by forskolin and 6-OAU stimulation and measured after 30 mins by luminescence method
ChEMBL 421 6 0 8 2.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3719364 134976 None 23 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in 6-OAU-induced inhibition of forskolin stimulated cAMP production preincubated for 15 mins followed by forskolin and 6-OAU stimulation and measured after 30 mins by luminescence methodAntagonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in 6-OAU-induced inhibition of forskolin stimulated cAMP production preincubated for 15 mins followed by forskolin and 6-OAU stimulation and measured after 30 mins by luminescence method
ChEMBL 421 6 0 8 2.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 10.1021/acs.jmedchem.0c01378
168286688 191606 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 364 4 1 5 4.1 c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ncccn2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5195413 191606 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 364 4 1 5 4.1 c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ncccn2)cc1 10.1021/acs.jmedchem.2c00804
153309755 192756 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 506 4 1 3 7.7 O=P(O)(O/C1=C/c2ccccc2CCc2ccccc21)O/C1=C/c2ccccc2CCc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5170786 192756 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 506 4 1 3 7.7 O=P(O)(O/C1=C/c2ccccc2CCc2ccccc21)O/C1=C/c2ccccc2CCc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221144 192756 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 506 4 1 3 7.7 O=P(O)(O/C1=C/c2ccccc2CCc2ccccc21)O/C1=C/c2ccccc2CCc2ccccc21 10.1021/acs.jmedchem.1c01813
153309768 192828 None 0 Mouse Functional pIC50 = 6.6 6.6 5 2
Antagonist activity at mouse GPR84 expressed in HEK293 cells assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at mouse GPR84 expressed in HEK293 cells assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5179395 192828 None 0 Mouse Functional pIC50 = 6.6 6.6 5 2
Antagonist activity at mouse GPR84 expressed in HEK293 cells assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at mouse GPR84 expressed in HEK293 cells assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221639 192828 None 0 Mouse Functional pIC50 = 6.6 6.6 5 2
Antagonist activity at mouse GPR84 expressed in HEK293 cells assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at mouse GPR84 expressed in HEK293 cells assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
76684891 134357 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 436 6 1 8 2.1 O=C(O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O 10.1021/acs.jmedchem.0c00272
CHEMBL3717307 134357 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 436 6 1 8 2.1 O=C(O)COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O 10.1021/acs.jmedchem.0c00272
148279656 192848 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2cccc(F)c2Sc2ccccc21)OC1=Cc2cccc(F)c2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5184044 192848 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2cccc(F)c2Sc2ccccc21)OC1=Cc2cccc(F)c2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221762 192848 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2cccc(F)c2Sc2ccccc21)OC1=Cc2cccc(F)c2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
71616526 134488 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of decanoic acid-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of decanoic acid-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 452 7 0 10 2.1 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3717743 134488 None 0 Human Functional pIC50 = 7.6 7.6 - 1
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of decanoic acid-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of decanoic acid-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 452 7 0 10 2.1 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 10.1021/acs.jmedchem.0c01378
168287473 191520 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 406 5 2 4 5.0 O=C(O)c1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5194077 191520 None 0 Human Functional pIC50 = 6.6 6.6 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 406 5 2 4 5.0 O=C(O)c1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168278353 191160 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 476 8 2 5 4.6 CN(C)CCNC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5188700 191160 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 476 8 2 5 4.6 CN(C)CCNC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168271424 190597 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 461 6 1 5 5.1 c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccc(CN3CCOCC3)cc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5180699 190597 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 461 6 1 5 5.1 c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccc(CN3CCOCC3)cc2)cc1 10.1021/acs.jmedchem.2c00804
153309761 192956 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2ccc(F)cc2Sc2ccccc21)OC1=Cc2ccc(F)cc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5198261 192956 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2ccc(F)cc2Sc2ccccc21)OC1=Cc2ccc(F)cc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222449 192956 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2ccc(F)cc2Sc2ccccc21)OC1=Cc2ccc(F)cc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
76684484 134278 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 328 4 0 6 2.0 COc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O 10.1021/acs.jmedchem.0c00272
CHEMBL3717000 134278 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 328 4 0 6 2.0 COc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O 10.1021/acs.jmedchem.0c00272
71616529 133876 None 0 Mouse Functional pIC50 = 6.5 6.5 -36 2
Antagonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3715656 133876 None 0 Mouse Functional pIC50 = 6.5 6.5 -36 2
Antagonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
153309834 192990 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 610 6 1 7 8.7 COc1cccc2c1Sc1c(F)cccc1C=C2OP(=O)(O)OC1=Cc2cccc(F)c2Sc2c(OC)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5201979 192990 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 610 6 1 7 8.7 COc1cccc2c1Sc1c(F)cccc1C=C2OP(=O)(O)OC1=Cc2cccc(F)c2Sc2c(OC)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222627 192990 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 610 6 1 7 8.7 COc1cccc2c1Sc1c(F)cccc1C=C2OP(=O)(O)OC1=Cc2cccc(F)c2Sc2c(OC)cccc21 10.1021/acs.jmedchem.1c01813
149043775 192959 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 630 8 1 7 10.0 CC(C)Oc1cccc2c1Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2c(OC(C)C)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5195223 192959 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 630 8 1 7 10.0 CC(C)Oc1cccc2c1Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2c(OC(C)C)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222466 192959 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 630 8 1 7 10.0 CC(C)Oc1cccc2c1Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2c(OC(C)C)cccc21 10.1021/acs.jmedchem.1c01813
168278009 190171 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 419 5 2 4 4.6 CNC(=O)c1cccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)c1 10.1021/acs.jmedchem.2c00804
CHEMBL5173991 190171 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 419 5 2 4 4.6 CNC(=O)c1cccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)c1 10.1021/acs.jmedchem.2c00804
168296821 192372 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 455 6 2 5 4.2 CNS(=O)(=O)c1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5207475 192372 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 455 6 2 5 4.2 CNS(=O)(=O)c1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168269664 189878 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 406 5 2 4 5.0 O=C(O)c1cccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)c1 10.1021/acs.jmedchem.2c00804
CHEMBL5169375 189878 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 406 5 2 4 5.0 O=C(O)c1cccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)c1 10.1021/acs.jmedchem.2c00804
153309832 193015 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2ccccc2Sc2c(F)cccc21)OC1=Cc2ccccc2Sc2c(F)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5207051 193015 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2ccccc2Sc2c(F)cccc21)OC1=Cc2ccccc2Sc2c(F)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222790 193015 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2ccccc2Sc2c(F)cccc21)OC1=Cc2ccccc2Sc2c(F)cccc21 10.1021/acs.jmedchem.1c01813
149469204 192014 None 0 Human Functional pIC50 = 7.5 7.5 4 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 514 4 1 5 8.4 O=P(O)(OC1=Cc2ccccc2Sc2ccccc21)OC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5194984 192014 None 0 Human Functional pIC50 = 7.5 7.5 4 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 514 4 1 5 8.4 O=P(O)(OC1=Cc2ccccc2Sc2ccccc21)OC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5201755 192014 None 0 Human Functional pIC50 = 7.5 7.5 4 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 514 4 1 5 8.4 O=P(O)(OC1=Cc2ccccc2Sc2ccccc21)OC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
168288085 191661 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 2 5 4.0 CNC(=O)c1ccc(-c2nc(Cc3c[nH]c4cnccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5196255 191661 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 2 5 4.0 CNC(=O)c1ccc(-c2nc(Cc3c[nH]c4cnccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168038773 191144 None 2 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 339 5 1 5 4.2 c1ccc(-c2nnc(NCc3cccnc3)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5188398 191144 None 2 Human Functional pIC50 = 5.5 5.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 339 5 1 5 4.2 c1ccc(-c2nnc(NCc3cccnc3)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168285407 191554 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 449 7 3 5 4.0 O=C(NCCO)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5194648 191554 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 449 7 3 5 4.0 O=C(NCCO)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
826353 189950 None 3 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 235 0 0 2 4.2 N#CC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5170482 189950 None 3 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 235 0 0 2 4.2 N#CC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
153309776 192773 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 574 6 1 7 8.5 COc1ccc2c(c1)C(OP(=O)(O)OC1=Cc3ccccc3Sc3ccc(OC)cc31)=Cc1ccccc1S2 10.1021/acs.jmedchem.1c01813
CHEMBL5171959 192773 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 574 6 1 7 8.5 COc1ccc2c(c1)C(OP(=O)(O)OC1=Cc3ccccc3Sc3ccc(OC)cc31)=Cc1ccccc1S2 10.1021/acs.jmedchem.1c01813
CHEMBL5221258 192773 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 574 6 1 7 8.5 COc1ccc2c(c1)C(OP(=O)(O)OC1=Cc3ccccc3Sc3ccc(OC)cc31)=Cc1ccccc1S2 10.1021/acs.jmedchem.1c01813
162658448 181148 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 383 5 0 7 2.6 COc1cc2c(cc1OC)-c1cc(OCc3ncccc3F)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
CHEMBL4760776 181148 None 0 Human Functional pIC50 = 6.5 6.5 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 383 5 0 7 2.6 COc1cc2c(cc1OC)-c1cc(OCc3ncccc3F)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
168280183 190834 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 363 4 0 5 4.4 c1ccc(-c2nnc(Cc3cnc4ccccn34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5184294 190834 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 363 4 0 5 4.4 c1ccc(-c2nnc(Cc3cnc4ccccn34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
153309814 192853 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 634 8 1 9 8.5 COc1cccc2c1Sc1c(OC)cccc1C(OP(=O)(O)OC1=Cc3cccc(OC)c3Sc3c(OC)cccc31)=C2 10.1021/acs.jmedchem.1c01813
CHEMBL5188247 192853 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 634 8 1 9 8.5 COc1cccc2c1Sc1c(OC)cccc1C(OP(=O)(O)OC1=Cc3cccc(OC)c3Sc3c(OC)cccc31)=C2 10.1021/acs.jmedchem.1c01813
CHEMBL5221808 192853 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 634 8 1 9 8.5 COc1cccc2c1Sc1c(OC)cccc1C(OP(=O)(O)OC1=Cc3cccc(OC)c3Sc3c(OC)cccc31)=C2 10.1021/acs.jmedchem.1c01813
153309795 192925 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 542 4 1 5 9.1 Cc1ccc2c(c1)Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2cc(C)ccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5192281 192925 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 542 4 1 5 9.1 Cc1ccc2c(c1)Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2cc(C)ccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222247 192925 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 542 4 1 5 9.1 Cc1ccc2c(c1)Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2cc(C)ccc21 10.1021/acs.jmedchem.1c01813
149016467 192834 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 450 4 1 3 7.9 O=P(O)(Oc1c2ccccc2cc2ccccc12)Oc1c2ccccc2cc2ccccc12 10.1021/acs.jmedchem.1c01813
CHEMBL5174911 192834 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 450 4 1 3 7.9 O=P(O)(Oc1c2ccccc2cc2ccccc12)Oc1c2ccccc2cc2ccccc12 10.1021/acs.jmedchem.1c01813
CHEMBL5221657 192834 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 450 4 1 3 7.9 O=P(O)(Oc1c2ccccc2cc2ccccc12)Oc1c2ccccc2cc2ccccc12 10.1021/acs.jmedchem.1c01813
162656291 180942 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 358 5 0 7 2.0 COc1cc2c(cc1OC)-c1cc(OCC3CCCO3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
CHEMBL4758226 180942 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 358 5 0 7 2.0 COc1cc2c(cc1OC)-c1cc(OCC3CCCO3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
89645206 134114 None 0 Mouse Functional pIC50 = 7.4 7.4 -50 2
Inverse agonist activity at recombinant mouse GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in IP1 accumulation incubated for 30 mins by HTRF based immunoassayInverse agonist activity at recombinant mouse GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in IP1 accumulation incubated for 30 mins by HTRF based immunoassay
ChEMBL 419 6 0 7 2.4 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(CCc3ccccn3)ccc1-2 10.1021/acs.jmedchem.0c00272
CHEMBL3716446 134114 None 0 Mouse Functional pIC50 = 7.4 7.4 -50 2
Inverse agonist activity at recombinant mouse GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in IP1 accumulation incubated for 30 mins by HTRF based immunoassayInverse agonist activity at recombinant mouse GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in IP1 accumulation incubated for 30 mins by HTRF based immunoassay
ChEMBL 419 6 0 7 2.4 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(CCc3ccccn3)ccc1-2 10.1021/acs.jmedchem.0c00272
168285211 191722 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 1 5 5.1 COC(=O)c1cccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)c1 10.1021/acs.jmedchem.2c00804
CHEMBL5197127 191722 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 1 5 5.1 COC(=O)c1cccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)c1 10.1021/acs.jmedchem.2c00804
153309787 193026 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 610 6 1 7 8.7 COc1cccc2c1Sc1cccc(F)c1C=C2OP(=O)(O)OC1=Cc2c(F)cccc2Sc2c(OC)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5205352 193026 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 610 6 1 7 8.7 COc1cccc2c1Sc1cccc(F)c1C=C2OP(=O)(O)OC1=Cc2c(F)cccc2Sc2c(OC)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222848 193026 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 610 6 1 7 8.7 COc1cccc2c1Sc1cccc(F)c1C=C2OP(=O)(O)OC1=Cc2c(F)cccc2Sc2c(OC)cccc21 10.1021/acs.jmedchem.1c01813
168268962 189937 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 462 6 1 6 4.5 c1ccc(-c2nc(Cc3c[nH]c4cnccc34)nnc2-c2ccc(CN3CCOCC3)cc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5170226 189937 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 462 6 1 6 4.5 c1ccc(-c2nc(Cc3c[nH]c4cnccc34)nnc2-c2ccc(CN3CCOCC3)cc2)cc1 10.1021/acs.jmedchem.2c00804
71616529 133876 None 0 Human Functional pIC50 = 8.3 8.3 36 2
Antagonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3715656 133876 None 0 Human Functional pIC50 = 8.3 8.3 36 2
Antagonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
153309749 192955 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2cccc(Cl)c2Sc2ccccc21)OC1=Cc2cccc(Cl)c2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5196283 192955 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2cccc(Cl)c2Sc2ccccc21)OC1=Cc2cccc(Cl)c2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222448 192955 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2cccc(Cl)c2Sc2ccccc21)OC1=Cc2cccc(Cl)c2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
168272643 190413 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 455 6 2 5 4.2 CNS(=O)(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5177895 190413 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 455 6 2 5 4.2 CNS(=O)(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
153309809 192919 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2cc(F)ccc2Sc2ccccc21)OC1=Cc2cc(F)ccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5195150 192919 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2cc(F)ccc2Sc2ccccc21)OC1=Cc2cc(F)ccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222219 192919 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 550 4 1 5 8.7 O=P(O)(OC1=Cc2cc(F)ccc2Sc2ccccc21)OC1=Cc2cc(F)ccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
149469204 192014 None 0 Human Functional pIC50 = 6.4 6.4 4 2
Antagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP productionAntagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP production
ChEMBL 514 4 1 5 8.4 O=P(O)(OC1=Cc2ccccc2Sc2ccccc21)OC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5194984 192014 None 0 Human Functional pIC50 = 6.4 6.4 4 2
Antagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP productionAntagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP production
ChEMBL 514 4 1 5 8.4 O=P(O)(OC1=Cc2ccccc2Sc2ccccc21)OC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5201755 192014 None 0 Human Functional pIC50 = 6.4 6.4 4 2
Antagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP productionAntagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP production
ChEMBL 514 4 1 5 8.4 O=P(O)(OC1=Cc2ccccc2Sc2ccccc21)OC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
168269754 190024 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 294 4 1 3 4.2 CC(C)c1nnc(Cc2c[nH]c3ccccc23)nc1C(C)C 10.1021/acs.jmedchem.2c00804
CHEMBL5171681 190024 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 294 4 1 3 4.2 CC(C)c1nnc(Cc2c[nH]c3ccccc23)nc1C(C)C 10.1021/acs.jmedchem.2c00804
168285639 191847 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 365 4 1 6 3.5 c1ccc(-c2nnc(Cc3c[nH]c4cnccc34)nc2-c2cnccn2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5199072 191847 None 0 Human Functional pIC50 = 5.4 5.4 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 365 4 1 6 3.5 c1ccc(-c2nnc(Cc3c[nH]c4cnccc34)nc2-c2cnccn2)cc1 10.1021/acs.jmedchem.2c00804
168291546 191990 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 421 5 1 6 4.5 COC(=O)c1ccc(-c2nc(Cc3c[nH]c4cnccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5201371 191990 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 421 5 1 6 4.5 COC(=O)c1ccc(-c2nc(Cc3c[nH]c4cnccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
86688463 134700 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 344 4 0 7 1.3 COc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O 10.1021/acs.jmedchem.0c00272
CHEMBL3718436 134700 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 344 4 0 7 1.3 COc1ccc2c(c1)CCn1c-2cc(OCC2COCCO2)nc1=O 10.1021/acs.jmedchem.0c00272
168294247 192260 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 2 5 4.0 CNC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccncc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5205576 192260 None 0 Human Functional pIC50 = 6.4 6.4 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 2 5 4.0 CNC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccncc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
147694370 192876 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 530 4 1 3 8.3 O=P(O)(OC1=Cc2ccccc2C2(CC2)c2ccccc21)OC1=Cc2ccccc2C2(CC2)c2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5183789 192876 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 530 4 1 3 8.3 O=P(O)(OC1=Cc2ccccc2C2(CC2)c2ccccc21)OC1=Cc2ccccc2C2(CC2)c2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221949 192876 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 530 4 1 3 8.3 O=P(O)(OC1=Cc2ccccc2C2(CC2)c2ccccc21)OC1=Cc2ccccc2C2(CC2)c2ccccc21 10.1021/acs.jmedchem.1c01813
149469204 192014 None 0 Mouse Functional pIC50 = 6.3 6.3 -4 2
Antagonist activity at mouse GPR84 expressed in HEK293 cells assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at mouse GPR84 expressed in HEK293 cells assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 514 4 1 5 8.4 O=P(O)(OC1=Cc2ccccc2Sc2ccccc21)OC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5194984 192014 None 0 Mouse Functional pIC50 = 6.3 6.3 -4 2
Antagonist activity at mouse GPR84 expressed in HEK293 cells assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at mouse GPR84 expressed in HEK293 cells assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 514 4 1 5 8.4 O=P(O)(OC1=Cc2ccccc2Sc2ccccc21)OC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5201755 192014 None 0 Mouse Functional pIC50 = 6.3 6.3 -4 2
Antagonist activity at mouse GPR84 expressed in HEK293 cells assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at mouse GPR84 expressed in HEK293 cells assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 514 4 1 5 8.4 O=P(O)(OC1=Cc2ccccc2Sc2ccccc21)OC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
153309778 192954 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 602 8 1 7 9.2 CCOc1cccc2c1Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2c(OCC)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5198754 192954 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 602 8 1 7 9.2 CCOc1cccc2c1Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2c(OCC)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222438 192954 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 602 8 1 7 9.2 CCOc1cccc2c1Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2c(OCC)cccc21 10.1021/acs.jmedchem.1c01813
71617557 133942 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 314 3 0 6 1.3 O=c1nc(OCC2COCCO2)cc2n1CCc1ccccc1-2 10.1021/acs.jmedchem.0c00272
CHEMBL3715879 133942 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 314 3 0 6 1.3 O=c1nc(OCC2COCCO2)cc2n1CCc1ccccc1-2 10.1021/acs.jmedchem.0c00272
168292609 192046 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 419 5 2 4 4.6 CNC(=O)c1cccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)c1 10.1021/acs.jmedchem.2c00804
CHEMBL5202325 192046 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 419 5 2 4 4.6 CNC(=O)c1cccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)c1 10.1021/acs.jmedchem.2c00804
168289914 191531 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 1 5 5.1 COC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5194322 191531 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 1 5 5.1 COC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
162672882 183105 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 440 8 0 7 3.5 O=c1nc(OCCOc2cnccn2)cc2n1CCc1cc(CCc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c00272
CHEMBL4742704 183105 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 440 8 0 7 3.5 O=c1nc(OCCOc2cnccn2)cc2n1CCc1cc(CCc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c00272
CHEMBL4794652 183105 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 440 8 0 7 3.5 O=c1nc(OCCOc2cnccn2)cc2n1CCc1cc(CCc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c00272
168281800 190971 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 434 6 1 5 5.3 CC(=O)OCc1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5186088 190971 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 434 6 1 5 5.3 CC(=O)OCc1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
164887573 190607 None 3 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 461 6 1 5 5.1 c1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccc(CN3CCOCC3)cc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5180818 190607 None 3 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 461 6 1 5 5.1 c1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccc(CN3CCOCC3)cc2)cc1 10.1021/acs.jmedchem.2c00804
75203411 133665 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 392 4 0 7 2.7 COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O 10.1021/acs.jmedchem.0c00272
CHEMBL3714917 133665 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 392 4 0 7 2.7 COc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O 10.1021/acs.jmedchem.0c00272
90253074 133630 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 533 6 0 9 2.7 CC(C)(Oc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)C(=O)N1CCOCC1 nan
CHEMBL3714778 133630 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 533 6 0 9 2.7 CC(C)(Oc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O)C(=O)N1CCOCC1 nan
90242304 133676 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 390 4 0 5 3.4 CC(C)C1CC(COc2cc3n(c(=O)n2)CCc2cc(C#CC4CC4)ccc2-3)O1 nan
CHEMBL3714950 133676 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 390 4 0 5 3.4 CC(C)C1CC(COc2cc3n(c(=O)n2)CCc2cc(C#CC4CC4)ccc2-3)O1 nan
76684580 133928 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 375 4 0 6 3.1 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(-c3cccnc3)ccc1-2 nan
CHEMBL3715834 133928 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 375 4 0 6 3.1 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(-c3cccnc3)ccc1-2 nan
76684673 134197 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 5 1 6 3.4 O=C(O)c1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
CHEMBL3716749 134197 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 418 5 1 6 3.4 O=C(O)c1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3CCCO3)nc2=O)c1 nan
90241698 134238 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 430 4 1 8 1.7 CNCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
CHEMBL3716896 134238 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 430 4 1 8 1.7 CNCC#Cc1ccc2c(c1)CCn1c-2cc(OCC2COc3ncccc3O2)nc1=O nan
90239911 134246 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 463 8 0 8 3.0 CN(C)CCCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
CHEMBL3716911 134246 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 463 8 0 8 3.0 CN(C)CCCOc1ccc2c(c1)CCn1c-2cc(OCC2COc3ccccc3O2)nc1=O nan
90242162 134248 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 399 4 0 6 3.6 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
CHEMBL3716913 134248 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 399 4 0 6 3.6 N#Cc1ccccc1-c1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
76684486 134498 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 376 4 0 6 2.9 COc1ccc2c(c1)CCn1c-2cc(OCC2Cc3ccccc3O2)nc1=O nan
CHEMBL3717778 134498 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 376 4 0 6 2.9 COc1ccc2c(c1)CCn1c-2cc(OCC2Cc3ccccc3O2)nc1=O nan
90242307 134521 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 395 6 0 8 2.6 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
CHEMBL3717849 134521 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 395 6 0 8 2.6 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3ncco3)ccc1-2 nan
76684574 134773 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 398 6 0 7 2.6 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCC3CCCO3)ccc1-2 nan
CHEMBL3718665 134773 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM HEPES at pH 7.4 by top-count assay
ChEMBL 398 6 0 7 2.6 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCC3CCCO3)ccc1-2 nan
76684773 134173 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 414 4 0 6 4.4 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(-c3ccc(Cl)s3)ccc1-2 nan
CHEMBL3716645 134173 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 414 4 0 6 4.4 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(-c3ccc(Cl)s3)ccc1-2 nan
76684771 134298 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 424 4 0 5 4.8 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(-c3cccc4ccccc34)ccc1-2 nan
CHEMBL3717070 134298 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 424 4 0 5 4.8 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(-c3cccc4ccccc34)ccc1-2 nan
90242114 134624 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 378 3 0 5 3.4 CC(C)(C)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
CHEMBL3718208 134624 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 378 3 0 5 3.4 CC(C)(C)C#Cc1ccc2c(c1)CCn1c-2cc(OCC2CCCO2)nc1=O nan
90242623 134809 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 454 6 0 6 4.8 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc4ccccc34)ccc1-2 nan
CHEMBL3718784 134809 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes assessed as inhibition of 3,3'-di-indolylmethane-induced [35S]GTPgammaS binding treated for 90 mins after 3,3'-di-indolylmethane stimulation in buffer containing 20 mM Tris at pH 7.5 by top-count assay
ChEMBL 454 6 0 6 4.8 O=c1nc(OCC2CCCO2)cc2n1CCc1cc(OCc3cccc4ccccc34)ccc1-2 nan
89645856 133652 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 438 3 1 8 1.2 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(C#CC3(O)CCOCC3)ccc1-2 nan
CHEMBL3714871 133652 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 438 3 1 8 1.2 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(C#CC3(O)CCOCC3)ccc1-2 nan
89645514 134005 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 416 8 0 8 2.1 CC(C)OCCOc1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
CHEMBL3716099 134005 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 416 8 0 8 2.1 CC(C)OCCOc1ccc2c(c1)CCn1c-2cc(OC[C@H]2COCCO2)nc1=O nan
89645350 134046 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 427 6 1 8 2.1 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(NCC3CCOCC3)ccc1-2 nan
CHEMBL3716225 134046 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 427 6 1 8 2.1 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(NCC3CCOCC3)ccc1-2 nan
71616970 134178 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 391 4 0 7 2.3 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(-c3ccncc3)ccc1-2 nan
CHEMBL3716680 134178 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 391 4 0 7 2.3 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(-c3ccncc3)ccc1-2 nan
89645690 134193 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 451 5 1 7 2.2 NC(=O)c1cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)ccc1F nan
CHEMBL3716729 134193 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 451 5 1 7 2.2 NC(=O)c1cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)ccc1F nan
71617559 134226 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 416 4 0 8 2.2 N#Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
CHEMBL3716848 134226 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 416 4 0 8 2.2 N#Cc1ccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
71616862 134279 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 7 0 8 1.8 CC1(COCc2ccc3c(c2)CCn2c-3cc(OC[C@@H]3COCCO3)nc2=O)COC1 nan
CHEMBL3717001 134279 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 428 7 0 8 1.8 CC1(COCc2ccc3c(c2)CCn2c-3cc(OC[C@@H]3COCCO3)nc2=O)COC1 nan
71617317 134543 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 382 4 1 7 1.0 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCCO)ccc1-2 nan
CHEMBL3717936 134543 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 382 4 1 7 1.0 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCCO)ccc1-2 nan
71616527 134583 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 416 3 0 8 1.5 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#Cc3ncccn3)ccc1-2 nan
CHEMBL3718076 134583 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 416 3 0 8 1.5 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#Cc3ncccn3)ccc1-2 nan
71616289 134785 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 408 5 0 8 2.1 CCn1cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
CHEMBL3718711 134785 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 408 5 0 8 2.1 CCn1cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)cn1 nan
71616972 134811 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 4 0 7 2.8 N#Cc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1 nan
CHEMBL3718792 134811 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 415 4 0 7 2.8 N#Cc1cccc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)c1 nan
89645640 134833 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 425 5 0 7 3.0 CN(c1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O)C1CCCCC1 nan
CHEMBL3718852 134833 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 425 5 0 7 3.0 CN(c1ccc2c(c1)CCn1c-2cc(OC[C@@H]2COCCO2)nc1=O)C1CCCCC1 nan
89645424 134907 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 376 6 0 7 1.6 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(OCCF)ccc1-2 nan
CHEMBL3719125 134907 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 376 6 0 7 1.6 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(OCCF)ccc1-2 nan
71617674 134912 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 405 4 0 7 2.6 Cc1cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)ccn1 nan
CHEMBL3719139 134912 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assayAntagonist activity against GPR84 (unknown origin) expressed in cell membranes incubated for 90 mins by [35S]GTPgammaS binding assay
ChEMBL 405 4 0 7 2.6 Cc1cc(-c2ccc3c(c2)CCn2c-3cc(OCC3COCCO3)nc2=O)ccn1 nan
168279661 191080 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 2 5 4.0 CNC(=O)c1ccc(-c2nnc(Cc3c[nH]c4cnccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5187543 191080 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 420 5 2 5 4.0 CNC(=O)c1ccc(-c2nnc(Cc3c[nH]c4cnccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168282833 191210 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 462 6 1 6 4.5 c1ccc(-c2nnc(Cc3c[nH]c4cnccc34)nc2-c2ccc(CN3CCOCC3)cc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5189536 191210 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 462 6 1 6 4.5 c1ccc(-c2nnc(Cc3c[nH]c4cnccc34)nc2-c2ccc(CN3CCOCC3)cc2)cc1 10.1021/acs.jmedchem.2c00804
10171 1811 None 20 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.0c00272
71616860 1811 None 20 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.0c00272
CHEMBL3716365 1811 None 20 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.0c00272
DB15346 1811 None 20 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.0c00272
168271681 190350 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 490 8 3 5 4.1 CC(=O)NCCNC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5176916 190350 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 490 8 3 5 4.1 CC(=O)NCCNC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
71617205 134899 None 1 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 378 3 0 6 2.0 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 10.1021/acs.jmedchem.0c00272
CHEMBL3719092 134899 None 1 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 378 3 0 6 2.0 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CC3CC3)ccc1-2 10.1021/acs.jmedchem.0c00272
89645365 133955 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of DIM-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of DIM-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 442 7 0 8 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CCOCC3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3715918 133955 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of DIM-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of DIM-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 442 7 0 8 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CCOCC3)ccc1-2 10.1021/acs.jmedchem.0c01378
153309830 192785 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 634 8 1 9 8.5 COc1ccc2c(c1)C=C(OP(=O)(O)OC1=Cc3cc(OC)ccc3Sc3c(OC)cccc31)c1cccc(OC)c1S2 10.1021/acs.jmedchem.1c01813
CHEMBL5175363 192785 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 634 8 1 9 8.5 COc1ccc2c(c1)C=C(OP(=O)(O)OC1=Cc3cc(OC)ccc3Sc3c(OC)cccc31)c1cccc(OC)c1S2 10.1021/acs.jmedchem.1c01813
CHEMBL5221361 192785 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 634 8 1 9 8.5 COc1ccc2c(c1)C=C(OP(=O)(O)OC1=Cc3cc(OC)ccc3Sc3c(OC)cccc31)c1cccc(OC)c1S2 10.1021/acs.jmedchem.1c01813
146807714 192765 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 508 4 1 5 7.7 CN1c2ccccc2C=C(OP(=O)(O)OC2=Cc3ccccc3N(C)c3ccccc32)c2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5170871 192765 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 508 4 1 5 7.7 CN1c2ccccc2C=C(OP(=O)(O)OC2=Cc3ccccc3N(C)c3ccccc32)c2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221218 192765 None 0 Human Functional pIC50 = 6.3 6.3 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 508 4 1 5 7.7 CN1c2ccccc2C=C(OP(=O)(O)OC2=Cc3ccccc3N(C)c3ccccc32)c2ccccc21 10.1021/acs.jmedchem.1c01813
10708352 189985 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 286 3 1 3 3.6 c1ccc(-c2cnc(Cc3c[nH]c4ccccc34)nn2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5171020 189985 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 286 3 1 3 3.6 c1ccc(-c2cnc(Cc3c[nH]c4ccccc34)nn2)cc1 10.1021/acs.jmedchem.2c00804
10171 1811 None 20 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP productionAntagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP production
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
71616860 1811 None 20 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP productionAntagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP production
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
CHEMBL3716365 1811 None 20 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP productionAntagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP production
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
DB15346 1811 None 20 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP productionAntagonist activity at human GPR84 expressed in HEK293 cells assessed as reversal of 6-OAU induced inhibition of forskolin induced intracellular cAMP production
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.1c01813
162656165 180871 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 353 4 0 6 2.6 COc1ccc2c(c1)CCn1c-2cc(OCc2ncccc2F)nc1=O 10.1021/acs.jmedchem.0c00272
CHEMBL4757413 180871 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 353 4 0 6 2.6 COc1ccc2c(c1)CCn1c-2cc(OCc2ncccc2F)nc1=O 10.1021/acs.jmedchem.0c00272
89645206 134114 None 0 Human Functional pIC50 = 8.2 8.2 50 2
Antagonist activity at recombinant human GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in capric acid-induced IP1 accumulation treated for 30 mins prior to capric acid stimulation measured after 1 hr by HTRF based immunoassayAntagonist activity at recombinant human GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in capric acid-induced IP1 accumulation treated for 30 mins prior to capric acid stimulation measured after 1 hr by HTRF based immunoassay
ChEMBL 419 6 0 7 2.4 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(CCc3ccccn3)ccc1-2 10.1021/acs.jmedchem.0c00272
CHEMBL3716446 134114 None 0 Human Functional pIC50 = 8.2 8.2 50 2
Antagonist activity at recombinant human GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in capric acid-induced IP1 accumulation treated for 30 mins prior to capric acid stimulation measured after 1 hr by HTRF based immunoassayAntagonist activity at recombinant human GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in capric acid-induced IP1 accumulation treated for 30 mins prior to capric acid stimulation measured after 1 hr by HTRF based immunoassay
ChEMBL 419 6 0 7 2.4 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(CCc3ccccn3)ccc1-2 10.1021/acs.jmedchem.0c00272
153309801 192918 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 574 6 1 7 8.5 COc1cccc2c1Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2c(OC)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5191944 192918 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 574 6 1 7 8.5 COc1cccc2c1Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2c(OC)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222213 192918 None 0 Human Functional pIC50 = 8.2 8.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 574 6 1 7 8.5 COc1cccc2c1Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2c(OC)cccc21 10.1021/acs.jmedchem.1c01813
168285471 192914 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 458 8 1 3 7.5 O=P(O)(O/C(=C\c1ccccc1)C1C=CC=CC1)O/C(=C\c1ccccc1)C1C=CC=CC1 10.1021/acs.jmedchem.1c01813
CHEMBL5196041 192914 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 458 8 1 3 7.5 O=P(O)(O/C(=C\c1ccccc1)C1C=CC=CC1)O/C(=C\c1ccccc1)C1C=CC=CC1 10.1021/acs.jmedchem.1c01813
CHEMBL5222190 192914 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 458 8 1 3 7.5 O=P(O)(O/C(=C\c1ccccc1)C1C=CC=CC1)O/C(=C\c1ccccc1)C1C=CC=CC1 10.1021/acs.jmedchem.1c01813
76684664 134036 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 342 4 0 6 2.4 COc1ccc2c(c1)CCn1c-2cc(OCC2CCCCO2)nc1=O 10.1021/acs.jmedchem.0c00272
CHEMBL3716185 134036 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 342 4 0 6 2.4 COc1ccc2c(c1)CCn1c-2cc(OCC2CCCCO2)nc1=O 10.1021/acs.jmedchem.0c00272
153309764 192895 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 506 4 1 5 6.6 O=c1c2ccccc2cc(OP(=O)(O)Oc2cc3ccccc3c(=O)c3ccccc23)c2ccccc12 10.1021/acs.jmedchem.1c01813
CHEMBL5184962 192895 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 506 4 1 5 6.6 O=c1c2ccccc2cc(OP(=O)(O)Oc2cc3ccccc3c(=O)c3ccccc23)c2ccccc12 10.1021/acs.jmedchem.1c01813
CHEMBL5222064 192895 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 506 4 1 5 6.6 O=c1c2ccccc2cc(OP(=O)(O)Oc2cc3ccccc3c(=O)c3ccccc23)c2ccccc12 10.1021/acs.jmedchem.1c01813
168281902 191091 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 365 4 1 6 3.5 c1ccc(-c2nc(Cc3c[nH]c4cnccc34)nnc2-c2ccnnc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5187711 191091 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 365 4 1 6 3.5 c1ccc(-c2nc(Cc3c[nH]c4cnccc34)nnc2-c2ccnnc2)cc1 10.1021/acs.jmedchem.2c00804
162655454 180774 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 394 7 0 7 2.9 COc1cc2c(cc1OC)-c1cc(OCCOc3ccccc3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
CHEMBL4756307 180774 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 394 7 0 7 2.9 COc1cc2c(cc1OC)-c1cc(OCCOc3ccccc3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
168274043 190254 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 419 6 1 4 5.3 CN(C)Cc1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5175411 190254 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 419 6 1 4 5.3 CN(C)Cc1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
162642975 181651 None 0 Mouse Functional pIC50 = 6.2 6.2 -67 2
Inverse agonist activity at recombinant mouse GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in IP1 accumulation incubated for 30 mins by HTRF based immunoassayInverse agonist activity at recombinant mouse GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in IP1 accumulation incubated for 30 mins by HTRF based immunoassay
ChEMBL 395 7 0 8 2.3 COc1cc2c(cc1OC)-c1cc(OCCOc3ccccn3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
CHEMBL4776061 181651 None 0 Mouse Functional pIC50 = 6.2 6.2 -67 2
Inverse agonist activity at recombinant mouse GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in IP1 accumulation incubated for 30 mins by HTRF based immunoassayInverse agonist activity at recombinant mouse GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction in IP1 accumulation incubated for 30 mins by HTRF based immunoassay
ChEMBL 395 7 0 8 2.3 COc1cc2c(cc1OC)-c1cc(OCCOc3ccccn3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
168281794 190958 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 475 5 1 5 4.8 O=C(c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1)N1CCOCC1 10.1021/acs.jmedchem.2c00804
CHEMBL5185972 190958 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 475 5 1 5 4.8 O=C(c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1)N1CCOCC1 10.1021/acs.jmedchem.2c00804
153309774 192944 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 542 4 1 5 9.1 Cc1ccc2c(c1)C(OP(=O)(O)OC1=Cc3ccccc3Sc3ccc(C)cc31)=Cc1ccccc1S2 10.1021/acs.jmedchem.1c01813
CHEMBL5192624 192944 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 542 4 1 5 9.1 Cc1ccc2c(c1)C(OP(=O)(O)OC1=Cc3ccccc3Sc3ccc(C)cc31)=Cc1ccccc1S2 10.1021/acs.jmedchem.1c01813
CHEMBL5222394 192944 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 542 4 1 5 9.1 Cc1ccc2c(c1)C(OP(=O)(O)OC1=Cc3ccccc3Sc3ccc(C)cc31)=Cc1ccccc1S2 10.1021/acs.jmedchem.1c01813
168292266 191872 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 419 5 2 4 4.6 CNC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5199559 191872 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 419 5 2 4 4.6 CNC(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168287166 191624 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 440 5 1 5 4.7 CS(=O)(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5195677 191624 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 440 5 1 5 4.7 CS(=O)(=O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
71616529 133876 None 0 Mouse Functional pIC50 = 7.2 7.2 -36 2
Antagonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3715656 133876 None 0 Mouse Functional pIC50 = 7.2 7.2 -36 2
Antagonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
168271441 190602 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 392 5 2 4 4.8 OCc1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5180745 190602 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 392 5 2 4 4.8 OCc1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
71616529 133876 None 0 Human Functional pIC50 = 8.1 8.1 36 2
Antagonist activity at human Flag-tagged Gialpha-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at human Flag-tagged Gialpha-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3715656 133876 None 0 Human Functional pIC50 = 8.1 8.1 36 2
Antagonist activity at human Flag-tagged Gialpha-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopyAntagonist activity at human Flag-tagged Gialpha-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding preincubated for 15 mins followed by ZQ-16 addition and subsequent addition of [35S]GTPgammaS measured after 60 mins by liquid scintillation spectroscopy
ChEMBL 443 5 1 7 2.7 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(C#CCNc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
168269632 190020 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 362 4 1 3 5.3 c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5171669 190020 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 362 4 1 3 5.3 c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
71598639 134976 None 23 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 421 6 0 8 2.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 10.1021/acs.jmedchem.1c01813
CHEMBL3719364 134976 None 23 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 421 6 0 8 2.2 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(OCc3ccccn3)ccc1-2 10.1021/acs.jmedchem.1c01813
1758434 67039 None 11 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 363 5 1 6 3.1 COc1cc2c(cc1OC)-c1cc(NCc3ccccc3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
CHEMBL1871173 67039 None 11 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 363 5 1 6 3.1 COc1cc2c(cc1OC)-c1cc(NCc3ccccc3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
149469204 192014 None 0 Human Functional pIC50 = 7.1 7.1 4 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 514 4 1 5 8.4 O=P(O)(OC1=Cc2ccccc2Sc2ccccc21)OC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5194984 192014 None 0 Human Functional pIC50 = 7.1 7.1 4 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 514 4 1 5 8.4 O=P(O)(OC1=Cc2ccccc2Sc2ccccc21)OC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5201755 192014 None 0 Human Functional pIC50 = 7.1 7.1 4 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 514 4 1 5 8.4 O=P(O)(OC1=Cc2ccccc2Sc2ccccc21)OC1=Cc2ccccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
168292093 191933 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 303 6 0 3 4.9 CCCCCc1nnc(-c2ccccc2)c(-c2ccccc2)n1 10.1021/acs.jmedchem.2c00804
CHEMBL5200441 191933 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 303 6 0 3 4.9 CCCCCc1nnc(-c2ccccc2)c(-c2ccccc2)n1 10.1021/acs.jmedchem.2c00804
89645206 134114 None 0 Human Functional pIC50 = 8.1 8.1 50 2
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 419 6 0 7 2.4 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(CCc3ccccn3)ccc1-2 10.1021/acs.jmedchem.0c00272
CHEMBL3716446 134114 None 0 Human Functional pIC50 = 8.1 8.1 50 2
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 419 6 0 7 2.4 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(CCc3ccccn3)ccc1-2 10.1021/acs.jmedchem.0c00272
162642975 181651 None 0 Human Functional pIC50 = 8.1 8.1 67 2
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 395 7 0 8 2.3 COc1cc2c(cc1OC)-c1cc(OCCOc3ccccn3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
CHEMBL4776061 181651 None 0 Human Functional pIC50 = 8.1 8.1 67 2
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 395 7 0 8 2.3 COc1cc2c(cc1OC)-c1cc(OCCOc3ccccn3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
168297026 192398 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 363 4 1 4 4.7 c1ccc(-c2nnc(Cc3c[nH]c4cnccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5207823 192398 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 363 4 1 4 4.7 c1ccc(-c2nnc(Cc3c[nH]c4cnccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
167175655 190071 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 434 6 1 5 5.3 CC(=O)OCc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5172567 190071 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 434 6 1 5 5.3 CC(=O)OCc1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
153309768 192828 None 0 Human Functional pIC50 = 8.1 8.1 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5179395 192828 None 0 Human Functional pIC50 = 8.1 8.1 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221639 192828 None 0 Human Functional pIC50 = 8.1 8.1 -5 2
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2c(Cl)cccc2Sc2ccccc21)OC1=Cc2c(Cl)cccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
162653421 180472 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 378 6 0 6 3.1 COc1cc2c(cc1OC)-c1cc(OCCc3ccccc3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
CHEMBL4752941 180472 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 378 6 0 6 3.1 COc1cc2c(cc1OC)-c1cc(OCCc3ccccc3)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
89645365 133955 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of embelin-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of embelin-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 442 7 0 8 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CCOCC3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3715918 133955 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of embelin-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of embelin-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 442 7 0 8 2.2 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1cc(COCC3CCOCC3)ccc1-2 10.1021/acs.jmedchem.0c01378
71616288 134564 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 409 6 1 8 2.5 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(NCc3ccco3)ccc1-2 10.1021/acs.jmedchem.0c00272
CHEMBL3718005 134564 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 409 6 1 8 2.5 O=c1nc(OCC2COCCO2)cc2n1CCc1cc(NCc3ccco3)ccc1-2 10.1021/acs.jmedchem.0c00272
162666623 182242 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 352 4 0 5 3.2 COc1ccc2c(c1)-c1cc(OCc3ccccc3F)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
CHEMBL4783553 182242 None 0 Human Functional pIC50 = 5.1 5.1 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 352 4 0 5 3.2 COc1ccc2c(c1)-c1cc(OCc3ccccc3F)nc(=O)n1CC2 10.1021/acs.jmedchem.0c00272
71616526 134488 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of DIM-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of DIM-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 452 7 0 10 2.1 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL3717743 134488 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of DIM-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometryAntagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibition of DIM-induced [35S]GTPgammaS binding pre-incubated for 15 mins followed by [35S]GTPgammaS addition and measured after 45 mins by liquid scintillation spectrometry
ChEMBL 452 7 0 10 2.1 O=c1nc(OC[C@H]2COCCO2)cc2n1CCc1cc(OCc3noc(C4CC4)n3)ccc1-2 10.1021/acs.jmedchem.0c01378
168282493 190771 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 406 5 2 4 5.0 O=C(O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5183310 190771 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 406 5 2 4 5.0 O=C(O)c1ccc(-c2nnc(Cc3c[nH]c4ccccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168295842 192245 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 440 5 1 5 4.7 CS(=O)(=O)c1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5205328 192245 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 440 5 1 5 4.7 CS(=O)(=O)c1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
162650087 180103 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 393 4 0 8 2.1 COc1ccc2c(c1)CCn1c-2cc(OCC2COc3cccnc3O2)nc1=O 10.1021/acs.jmedchem.0c00272
CHEMBL4748375 180103 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting methodAntagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-stimulated [35S]GTPgammaS binding after 90 mins by scintillation counting method
ChEMBL 393 4 0 8 2.1 COc1ccc2c(c1)CCn1c-2cc(OCC2COc3cccnc3O2)nc1=O 10.1021/acs.jmedchem.0c00272
153309757 192897 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2cc(Cl)ccc2Sc2ccccc21)OC1=Cc2cc(Cl)ccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5187339 192897 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2cc(Cl)ccc2Sc2ccccc21)OC1=Cc2cc(Cl)ccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5222073 192897 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 582 4 1 5 9.8 O=P(O)(OC1=Cc2cc(Cl)ccc2Sc2ccccc21)OC1=Cc2cc(Cl)ccc2Sc2ccccc21 10.1021/acs.jmedchem.1c01813
153309820 192819 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 542 4 1 5 9.1 Cc1cccc2c1Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2c(C)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5177531 192819 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 542 4 1 5 9.1 Cc1cccc2c1Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2c(C)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221528 192819 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 542 4 1 5 9.1 Cc1cccc2c1Sc1ccccc1C=C2OP(=O)(O)OC1=Cc2ccccc2Sc2c(C)cccc21 10.1021/acs.jmedchem.1c01813
148925847 192822 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 610 6 1 7 8.7 COc1cccc2c1Sc1cc(F)ccc1C=C2OP(=O)(O)OC1=Cc2ccc(F)cc2Sc2c(OC)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5176994 192822 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 610 6 1 7 8.7 COc1cccc2c1Sc1cc(F)ccc1C=C2OP(=O)(O)OC1=Cc2ccc(F)cc2Sc2c(OC)cccc21 10.1021/acs.jmedchem.1c01813
CHEMBL5221558 192822 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assayAntagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in 6-OAU induced intracellular calcium response preincubated for 10 mins followed by agonist addition and measured after 1 min by calcium mobilization assay
ChEMBL 610 6 1 7 8.7 COc1cccc2c1Sc1cc(F)ccc1C=C2OP(=O)(O)OC1=Cc2ccc(F)cc2Sc2c(OC)cccc21 10.1021/acs.jmedchem.1c01813
168271098 190066 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 419 5 2 4 4.6 CNC(=O)c1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5172502 190066 None 0 Human Functional pIC50 = 8.0 8.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 419 5 2 4 4.6 CNC(=O)c1ccc(-c2nc(Cc3c[nH]c4ccccc34)nnc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168287306 191792 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 450 7 3 6 3.4 O=C(NCCO)c1ccc(-c2nnc(Cc3c[nH]c4cnccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5198225 191792 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 450 7 3 6 3.4 O=C(NCCO)c1ccc(-c2nnc(Cc3c[nH]c4cnccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
168297809 192248 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 421 5 1 6 4.5 COC(=O)c1ccc(-c2nnc(Cc3c[nH]c4cnccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
CHEMBL5205398 192248 None 0 Human Functional pIC50 = 7.0 7.0 - 1
Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysisAntagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35S]GTPgammaS binding preincubated for 15 mins followed by PSB-16671 addition and measured after 45 mins by liquid scintillation counting analysis
ChEMBL 421 5 1 6 4.5 COC(=O)c1ccc(-c2nnc(Cc3c[nH]c4cnccc34)nc2-c2ccccc2)cc1 10.1021/acs.jmedchem.2c00804
3893 2285 None 98 Human Functional pEC50 = 8.3 8.3 -3 4
NoneNone
Drug Central 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O None
4642 2285 None 98 Human Functional pEC50 = 8.3 8.3 -3 4
NoneNone
Drug Central 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O None
5534 2285 None 98 Human Functional pEC50 = 8.3 8.3 -3 4
NoneNone
Drug Central 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O None
CHEMBL108766 2285 None 98 Human Functional pEC50 = 8.3 8.3 -3 4
NoneNone
Drug Central 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O None
DB03017 2285 None 98 Human Functional pEC50 = 8.3 8.3 -3 4
NoneNone
Drug Central 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O None
13103 2973 None 0 Human Functional pEC50 = 10.7 10.7 - 1
Measured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cellsMeasured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cells
Guide to Pharmacology 331 4 1 2 3.9 ClC1=C(C=C(C=C1)CCCC=2C=[N+](C=C(C2)O)[O-])C(F)(F)F 38146625
171037436 2973 None 0 Human Functional pEC50 = 10.7 10.7 - 1
Measured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cellsMeasured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cells
Guide to Pharmacology 331 4 1 2 3.9 ClC1=C(C=C(C=C1)CCCC=2C=[N+](C=C(C2)O)[O-])C(F)(F)F 38146625
11213 1440 None 5 Human Functional pEC50 = 7.9 7.9 - 1
Measured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cellsMeasured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cells
Guide to Pharmacology 299 4 0 2 3.7 [O-][n+]1cccc(c1)CCOc1ccc(c2c1cccc2)Cl 32869860
11213 1440 None 5 Human Functional pEC50 = 7.9 7.9 - 1
Measured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cellsMeasured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cells
Guide to Pharmacology 299 4 0 2 3.7 [O-][n+]1cccc(c1)CCOc1ccc(c2c1cccc2)Cl 38146625
154578239 1440 None 5 Human Functional pEC50 = 7.9 7.9 - 1
Measured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cellsMeasured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cells
Guide to Pharmacology 299 4 0 2 3.7 [O-][n+]1cccc(c1)CCOc1ccc(c2c1cccc2)Cl 32869860
154578239 1440 None 5 Human Functional pEC50 = 7.9 7.9 - 1
Measured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cellsMeasured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cells
Guide to Pharmacology 299 4 0 2 3.7 [O-][n+]1cccc(c1)CCOc1ccc(c2c1cccc2)Cl 38146625
CHEMBL4743442 1440 None 5 Human Functional pEC50 = 7.9 7.9 - 1
Measured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cellsMeasured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cells
Guide to Pharmacology 299 4 0 2 3.7 [O-][n+]1cccc(c1)CCOc1ccc(c2c1cccc2)Cl 32869860
CHEMBL4743442 1440 None 5 Human Functional pEC50 = 7.9 7.9 - 1
Measured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cellsMeasured as inhibition of forskolin-induced cAMP production in CHO-hGPR84 cells
Guide to Pharmacology 299 4 0 2 3.7 [O-][n+]1cccc(c1)CCOc1ccc(c2c1cccc2)Cl 38146625
10717 3208 None 4 Human Functional pEC50 = 8.5 8.5 - 1
Potency in a β-arrestin recruitment assay.Potency in a β-arrestin recruitment assay.
Guide to Pharmacology 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 30023867
44349321 3208 None 4 Human Functional pEC50 = 8.5 8.5 - 1
Potency in a β-arrestin recruitment assay.Potency in a β-arrestin recruitment assay.
Guide to Pharmacology 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 30023867
CHEMBL124977 3208 None 4 Human Functional pEC50 = 8.5 8.5 - 1
Potency in a β-arrestin recruitment assay.Potency in a β-arrestin recruitment assay.
Guide to Pharmacology 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 30023867
10717 3208 None 4 Human Functional pEC50 = 8.3 8.3 - 1
Potency in a cAMP assay.Potency in a cAMP assay.
Guide to Pharmacology 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 30023867
44349321 3208 None 4 Human Functional pEC50 = 8.3 8.3 - 1
Potency in a cAMP assay.Potency in a cAMP assay.
Guide to Pharmacology 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 30023867
CHEMBL124977 3208 None 4 Human Functional pEC50 = 8.3 8.3 - 1
Potency in a cAMP assay.Potency in a cAMP assay.
Guide to Pharmacology 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 30023867
26612 99 None 79 Human Functional pEC50 = 3.6 3.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology 188 8 2 2 2.2 CCCCCCCC(CC(=O)O)O 23449982
5848 99 None 79 Human Functional pEC50 = 3.6 3.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology 188 8 2 2 2.2 CCCCCCCC(CC(=O)O)O 23449982
CHEMBL4448230 99 None 79 Human Functional pEC50 = 3.6 3.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology 188 8 2 2 2.2 CCCCCCCC(CC(=O)O)O 23449982
21488 65 None 0 Human Functional pEC50 = 4.5 4.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 188 8 2 2 2.2 CCCCCCCCC(C(=O)O)O 23449982
5847 65 None 0 Human Functional pEC50 = 4.5 4.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 188 8 2 2 2.2 CCCCCCCCC(C(=O)O)O 23449982
5850 100 None 63 Human Functional pEC50 = 4.9 4.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 23449982
94216 100 None 63 Human Functional pEC50 = 4.9 4.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 23449982
CHEMBL4288936 100 None 63 Human Functional pEC50 = 4.9 4.9 - 1
UnclassifiedUnclassified
Guide to Pharmacology 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 23449982
5849 66 None 44 Human Functional pEC50 = 5 5.0 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 216 10 2 2 3.0 CCCCCCCCCCC(C(=O)O)O 23449982
97783 66 None 44 Human Functional pEC50 = 5 5.0 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 216 10 2 2 3.0 CCCCCCCCCCC(C(=O)O)O 23449982
CHEMBL4278254 66 None 44 Human Functional pEC50 = 5 5.0 -1 2
UnclassifiedUnclassified
Guide to Pharmacology 216 10 2 2 3.0 CCCCCCCCCCC(C(=O)O)O 23449982
3893 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
UnclassifiedUnclassified
Guide to Pharmacology 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 16966319
4642 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
UnclassifiedUnclassified
Guide to Pharmacology 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 16966319
5534 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
UnclassifiedUnclassified
Guide to Pharmacology 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 16966319
CHEMBL108766 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
UnclassifiedUnclassified
Guide to Pharmacology 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 16966319
DB03017 2285 None 98 Human Functional pEC50 = 5.1 5.1 -3 4
UnclassifiedUnclassified
Guide to Pharmacology 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 16966319
5533 3941 None 104 Human Functional pEC50 = 5.1 5.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 16966319
8180 3941 None 104 Human Functional pEC50 = 5.1 5.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 16966319
CHEMBL108030 3941 None 104 Human Functional pEC50 = 5.1 5.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 16966319
135373094 1356 None 95 Human Functional pEC50 = 5.2 5.2 2 2
UnclassifiedUnclassified
Guide to Pharmacology 172 8 1 1 3.2 CCCCCCCCCC(=O)O 16966319
135373094 1356 None 95 Human Functional pEC50 = 5.2 5.2 2 2
UnclassifiedUnclassified
Guide to Pharmacology 172 8 1 1 3.2 CCCCCCCCCC(=O)O 23396314
2969 1356 None 95 Human Functional pEC50 = 5.2 5.2 2 2
UnclassifiedUnclassified
Guide to Pharmacology 172 8 1 1 3.2 CCCCCCCCCC(=O)O 16966319
2969 1356 None 95 Human Functional pEC50 = 5.2 5.2 2 2
UnclassifiedUnclassified
Guide to Pharmacology 172 8 1 1 3.2 CCCCCCCCCC(=O)O 23396314
5532 1356 None 95 Human Functional pEC50 = 5.2 5.2 2 2
UnclassifiedUnclassified
Guide to Pharmacology 172 8 1 1 3.2 CCCCCCCCCC(=O)O 16966319
5532 1356 None 95 Human Functional pEC50 = 5.2 5.2 2 2
UnclassifiedUnclassified
Guide to Pharmacology 172 8 1 1 3.2 CCCCCCCCCC(=O)O 23396314
CHEMBL107498 1356 None 95 Human Functional pEC50 = 5.2 5.2 2 2
UnclassifiedUnclassified
Guide to Pharmacology 172 8 1 1 3.2 CCCCCCCCCC(=O)O 16966319
CHEMBL107498 1356 None 95 Human Functional pEC50 = 5.2 5.2 2 2
UnclassifiedUnclassified
Guide to Pharmacology 172 8 1 1 3.2 CCCCCCCCCC(=O)O 23396314
DB03600 1356 None 95 Human Functional pEC50 = 5.2 5.2 2 2
UnclassifiedUnclassified
Guide to Pharmacology 172 8 1 1 3.2 CCCCCCCCCC(=O)O 16966319
DB03600 1356 None 95 Human Functional pEC50 = 5.2 5.2 2 2
UnclassifiedUnclassified
Guide to Pharmacology 172 8 1 1 3.2 CCCCCCCCCC(=O)O 23396314
10354234 164 None 46 Human Functional pEC50 = 7 7.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 23449982
5846 164 None 46 Human Functional pEC50 = 7 7.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 23449982
CHEMBL3827832 164 None 46 Human Functional pEC50 = 7 7.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 23449982
133081959 3211 None 1 Human Functional pEC50 = 8.7 8.7 - 1
UnclassifiedUnclassified
Guide to Pharmacology 309 4 3 3 1.5 Brc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 30023867
9871 3211 None 1 Human Functional pEC50 = 8.7 8.7 - 1
UnclassifiedUnclassified
Guide to Pharmacology 309 4 3 3 1.5 Brc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 30023867
CHEMBL4444010 3211 None 1 Human Functional pEC50 = 8.7 8.7 - 1
UnclassifiedUnclassified
Guide to Pharmacology 309 4 3 3 1.5 Brc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 30023867
12819 3009 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonisn of sodium decanoate-mediated GPR84 activation, determined in a BRET biosensor assay measuring Gαi protein activation in HEK293 cells.Antagonisn of sodium decanoate-mediated GPR84 activation, determined in a BRET biosensor assay measuring Gαi protein activation in HEK293 cells.
Guide to Pharmacology 275 10 0 2 3.4 C(CCCC)C=1C=C(C=C(C1)CCCCC)CC(=O)[O-] 32728158
140700741 3009 None 0 Human Functional pIC50 = 4.8 4.8 - 1
Antagonisn of sodium decanoate-mediated GPR84 activation, determined in a BRET biosensor assay measuring Gαi protein activation in HEK293 cells.Antagonisn of sodium decanoate-mediated GPR84 activation, determined in a BRET biosensor assay measuring Gαi protein activation in HEK293 cells.
Guide to Pharmacology 275 10 0 2 3.4 C(CCCC)C=1C=C(C=C(C1)CCCCC)CC(=O)[O-] 32728158
10043 3592 None 0 Human Functional pIC50 = 3.4 3.4 2 2
Measuring antagonist-dependent inhibition of G&alpha;<sub>i</sub>activation by sodium decanoate (agonist) in receptor transfected HEK293 cells.Measuring antagonist-dependent inhibition of G&alpha;<sub>i</sub>activation by sodium decanoate (agonist) in receptor transfected HEK293 cells.
Guide to Pharmacology 206 6 1 1 3.0 CCCCCc1cccc(c1)CC(=O)O 29454750
24749700 3592 None 0 Human Functional pIC50 = 3.4 3.4 2 2
Measuring antagonist-dependent inhibition of G&alpha;<sub>i</sub>activation by sodium decanoate (agonist) in receptor transfected HEK293 cells.Measuring antagonist-dependent inhibition of G&alpha;<sub>i</sub>activation by sodium decanoate (agonist) in receptor transfected HEK293 cells.
Guide to Pharmacology 206 6 1 1 3.0 CCCCCc1cccc(c1)CC(=O)O 29454750
CHEMBL4297635 3592 None 0 Human Functional pIC50 = 3.4 3.4 2 2
Measuring antagonist-dependent inhibition of G&alpha;<sub>i</sub>activation by sodium decanoate (agonist) in receptor transfected HEK293 cells.Measuring antagonist-dependent inhibition of G&alpha;<sub>i</sub>activation by sodium decanoate (agonist) in receptor transfected HEK293 cells.
Guide to Pharmacology 206 6 1 1 3.0 CCCCCc1cccc(c1)CC(=O)O 29454750
DB15447 3592 None 0 Human Functional pIC50 = 3.4 3.4 2 2
Measuring antagonist-dependent inhibition of G&alpha;<sub>i</sub>activation by sodium decanoate (agonist) in receptor transfected HEK293 cells.Measuring antagonist-dependent inhibition of G&alpha;<sub>i</sub>activation by sodium decanoate (agonist) in receptor transfected HEK293 cells.
Guide to Pharmacology 206 6 1 1 3.0 CCCCCc1cccc(c1)CC(=O)O 29454750


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
135373094 1356 None 95 Human Binding pEC50 = 5 5.0 - 1
Agonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assayAgonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
2969 1356 None 95 Human Binding pEC50 = 5 5.0 - 1
Agonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assayAgonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
5532 1356 None 95 Human Binding pEC50 = 5 5.0 - 1
Agonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assayAgonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
CHEMBL107498 1356 None 95 Human Binding pEC50 = 5 5.0 - 1
Agonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assayAgonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
DB03600 1356 None 95 Human Binding pEC50 = 5 5.0 - 1
Agonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assayAgonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
135373094 1356 None 95 Human Binding pEC50 = 5 5.0 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1356 None 95 Human Binding pEC50 = 5 5.0 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1356 None 95 Human Binding pEC50 = 5 5.0 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1356 None 95 Human Binding pEC50 = 5 5.0 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1356 None 95 Human Binding pEC50 = 5 5.0 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
9944370 93511 None 4 Human Binding pEC50 = 7.0 7.0 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 306 4 2 2 4.3 COc1ccc2[nH]cc(Cc3c[nH]c4ccc(OC)cc34)c2c1 10.1021/acs.jmedchem.9b01339
CHEMBL246298 93511 None 4 Human Binding pEC50 = 7.0 7.0 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 306 4 2 2 4.3 COc1ccc2[nH]cc(Cc3c[nH]c4ccc(OC)cc34)c2c1 10.1021/acs.jmedchem.9b01339
137649817 157409 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 318 2 2 0 4.8 Fc1cc2[nH]cc(Cc3c[nH]c4cc(F)c(F)cc34)c2cc1F 10.1021/acs.jmedchem.6b01593
CHEMBL4078546 157409 None 0 Human Binding pEC50 = 5.0 5.0 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 318 2 2 0 4.8 Fc1cc2[nH]cc(Cc3c[nH]c4cc(F)c(F)cc34)c2cc1F 10.1021/acs.jmedchem.6b01593
133081959 3211 None 1 Human Binding pEC50 = 7.0 7.0 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 309 4 3 3 1.5 Brc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
9871 3211 None 1 Human Binding pEC50 = 7.0 7.0 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 309 4 3 3 1.5 Brc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4444010 3211 None 1 Human Binding pEC50 = 7.0 7.0 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 309 4 3 3 1.5 Brc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
137649231 157133 None 0 Human Binding pEC50 = 6.0 6.0 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 264 2 2 0 4.4 Fc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4075099 157133 None 0 Human Binding pEC50 = 6.0 6.0 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 264 2 2 0 4.4 Fc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
10354234 164 None 46 Human Binding pEC50 = 5.0 5.0 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.0c01378
5846 164 None 46 Human Binding pEC50 = 5.0 5.0 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3827832 164 None 46 Human Binding pEC50 = 5.0 5.0 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.0c01378
10354234 164 None 46 Human Binding pEC50 = 6.9 6.9 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5846 164 None 46 Human Binding pEC50 = 6.9 6.9 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827832 164 None 46 Human Binding pEC50 = 6.9 6.9 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
9944370 93511 None 4 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 306 4 2 2 4.3 COc1ccc2[nH]cc(Cc3c[nH]c4ccc(OC)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL246298 93511 None 4 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 306 4 2 2 4.3 COc1ccc2[nH]cc(Cc3c[nH]c4ccc(OC)cc34)c2c1 10.1021/acs.jmedchem.6b01593
137658671 159446 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 282 2 2 0 4.5 Fc1cccc2[nH]cc(Cc3c[nH]c4cccc(F)c34)c12 10.1021/acs.jmedchem.6b01593
CHEMBL4101219 159446 None 0 Human Binding pEC50 = 5.9 5.9 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 282 2 2 0 4.5 Fc1cccc2[nH]cc(Cc3c[nH]c4cccc(F)c34)c12 10.1021/acs.jmedchem.6b01593
11209 1550 None 95 Human Binding pEC50 = 4.9 4.9 - 1
Agonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assayAgonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.6b01593
3218 1550 None 95 Human Binding pEC50 = 4.9 4.9 - 1
Agonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assayAgonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.6b01593
CHEMBL221137 1550 None 95 Human Binding pEC50 = 4.9 4.9 - 1
Agonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assayAgonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.6b01593
137658184 159749 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 350 2 2 0 5.8 Fc1cc2c(Cc3c[nH]c4cc(Cl)c(F)cc34)c[nH]c2cc1Cl 10.1021/acs.jmedchem.9b01339
CHEMBL4104992 159749 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 350 2 2 0 5.8 Fc1cc2c(Cc3c[nH]c4cc(Cl)c(F)cc34)c[nH]c2cc1Cl 10.1021/acs.jmedchem.9b01339
137658671 159446 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 282 2 2 0 4.5 Fc1cccc2[nH]cc(Cc3c[nH]c4cccc(F)c34)c12 10.1021/acs.jmedchem.9b01339
CHEMBL4101219 159446 None 0 Human Binding pEC50 = 5.8 5.8 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 282 2 2 0 4.5 Fc1cccc2[nH]cc(Cc3c[nH]c4cccc(F)c34)c12 10.1021/acs.jmedchem.9b01339
11208 1422 None 113 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
3071 1422 None 113 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
CHEMBL446452 1422 None 113 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
DB11875 1422 None 113 Human Binding pEC50 = 5.8 5.8 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01593
12530 5789 None 92 Human Binding pEC50 = 5.8 5.8 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 214 11 1 1 4.4 CCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107874 5789 None 92 Human Binding pEC50 = 5.8 5.8 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 214 11 1 1 4.4 CCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
137632827 156391 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 314 2 2 0 5.5 Clc1cccc2[nH]cc(Cc3c[nH]c4cccc(Cl)c34)c12 10.1021/acs.jmedchem.9b01339
CHEMBL4066454 156391 None 0 Human Binding pEC50 = 6.8 6.8 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 314 2 2 0 5.5 Clc1cccc2[nH]cc(Cc3c[nH]c4cccc(Cl)c34)c12 10.1021/acs.jmedchem.9b01339
10354234 164 None 46 Human Binding pEC50 = 5.8 5.8 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment measured after 20 mins by luciferase reporter gene assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment measured after 20 mins by luciferase reporter gene assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5846 164 None 46 Human Binding pEC50 = 5.8 5.8 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment measured after 20 mins by luciferase reporter gene assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment measured after 20 mins by luciferase reporter gene assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827832 164 None 46 Human Binding pEC50 = 5.8 5.8 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment measured after 20 mins by luciferase reporter gene assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment measured after 20 mins by luciferase reporter gene assay
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
12380289 158190 None 3 Human Binding pEC50 = 4.7 4.7 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 260 2 2 1 3.9 O=C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.6b01593
CHEMBL4087824 158190 None 3 Human Binding pEC50 = 4.7 4.7 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 260 2 2 1 3.9 O=C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.6b01593
12380289 158190 None 3 Human Binding pEC50 = 5.7 5.7 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 260 2 2 1 3.9 O=C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.9b01339
CHEMBL4087824 158190 None 3 Human Binding pEC50 = 5.7 5.7 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 260 2 2 1 3.9 O=C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.9b01339
9882204 159486 None 17 Human Binding pEC50 = 6.7 6.7 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 282 2 2 0 4.5 Fc1ccc2[nH]cc(Cc3c[nH]c4ccc(F)cc34)c2c1 10.1021/acs.jmedchem.9b01339
CHEMBL4101728 159486 None 17 Human Binding pEC50 = 6.7 6.7 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 282 2 2 0 4.5 Fc1ccc2[nH]cc(Cc3c[nH]c4ccc(F)cc34)c2c1 10.1021/acs.jmedchem.9b01339
12037446 159771 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 248 2 2 2 3.0 c1cnc2[nH]cc(Cc3c[nH]c4ncccc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4105236 159771 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 248 2 2 2 3.0 c1cnc2[nH]cc(Cc3c[nH]c4ncccc34)c2c1 10.1021/acs.jmedchem.6b01593
9901435 158997 None 4 Human Binding pEC50 = 6.6 6.6 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 314 2 2 0 5.5 Clc1ccc2[nH]cc(Cc3c[nH]c4ccc(Cl)cc34)c2c1 10.1021/acs.jmedchem.9b01339
CHEMBL4096406 158997 None 4 Human Binding pEC50 = 6.6 6.6 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 314 2 2 0 5.5 Clc1ccc2[nH]cc(Cc3c[nH]c4ccc(Cl)cc34)c2c1 10.1021/acs.jmedchem.9b01339
137649231 157133 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 264 2 2 0 4.4 Fc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.9b01339
CHEMBL4075099 157133 None 0 Human Binding pEC50 = 6.6 6.6 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 264 2 2 0 4.4 Fc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.9b01339
11150029 158006 None 2 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 274 3 2 0 5.2 CCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.6b01593
CHEMBL4085470 158006 None 2 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 274 3 2 0 5.2 CCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.6b01593
2778732 158140 None 116 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 153 0 1 0 2.4 Fc1cc2cc[nH]c2cc1F 10.1021/acs.jmedchem.6b01593
CHEMBL4087204 158140 None 116 Human Binding pEC50 = 5.5 5.5 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 153 0 1 0 2.4 Fc1cc2cc[nH]c2cc1F 10.1021/acs.jmedchem.6b01593
10717 3208 None 4 Human Binding pEC50 = 8.5 8.5 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
44349321 3208 None 4 Human Binding pEC50 = 8.5 8.5 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL124977 3208 None 4 Human Binding pEC50 = 8.5 8.5 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
72711216 157763 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 282 2 2 0 4.5 Fc1ccc2c(Cc3c[nH]c4cc(F)ccc34)c[nH]c2c1 10.1021/acs.jmedchem.9b01339
CHEMBL4082668 157763 None 0 Human Binding pEC50 = 6.5 6.5 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 282 2 2 0 4.5 Fc1ccc2c(Cc3c[nH]c4cc(F)ccc34)c[nH]c2c1 10.1021/acs.jmedchem.9b01339
5850 100 None 63 Human Binding pEC50 = 5.5 5.5 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
94216 100 None 63 Human Binding pEC50 = 5.5 5.5 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
CHEMBL4288936 100 None 63 Human Binding pEC50 = 5.5 5.5 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
3893 2285 None 98 Human Binding pEC50 = 5.5 5.5 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
4642 2285 None 98 Human Binding pEC50 = 5.5 5.5 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5534 2285 None 98 Human Binding pEC50 = 5.5 5.5 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL108766 2285 None 98 Human Binding pEC50 = 5.5 5.5 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03017 2285 None 98 Human Binding pEC50 = 5.5 5.5 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
11208 1422 None 113 Human Binding pEC50 = 6.4 6.4 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
3071 1422 None 113 Human Binding pEC50 = 6.4 6.4 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
CHEMBL446452 1422 None 113 Human Binding pEC50 = 6.4 6.4 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
DB11875 1422 None 113 Human Binding pEC50 = 6.4 6.4 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 246 2 2 0 4.2 c1ccc2c(c1)c(c[nH]2)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.9b01339
137658184 159749 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 350 2 2 0 5.8 Fc1cc2c(Cc3c[nH]c4cc(Cl)c(F)cc34)c[nH]c2cc1Cl 10.1021/acs.jmedchem.6b01593
CHEMBL4104992 159749 None 0 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 350 2 2 0 5.8 Fc1cc2c(Cc3c[nH]c4cc(Cl)c(F)cc34)c[nH]c2cc1Cl 10.1021/acs.jmedchem.6b01593
11209 1550 None 95 Human Binding pEC50 = 6.4 6.4 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.6b01593
3218 1550 None 95 Human Binding pEC50 = 6.4 6.4 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.6b01593
CHEMBL221137 1550 None 95 Human Binding pEC50 = 6.4 6.4 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.6b01593
26612 99 None 79 Human Binding pEC50 = 5.4 5.4 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 188 8 2 2 2.2 CCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
5848 99 None 79 Human Binding pEC50 = 5.4 5.4 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 188 8 2 2 2.2 CCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
CHEMBL4448230 99 None 79 Human Binding pEC50 = 5.4 5.4 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 188 8 2 2 2.2 CCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
137643701 158276 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.9b01339
CHEMBL4088884 158276 None 0 Human Binding pEC50 = 7.4 7.4 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.9b01339
11209 1550 None 95 Human Binding pEC50 = 6.4 6.4 - 1
Agonist activity at human PK-tagged GPR84 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase complementation assayAgonist activity at human PK-tagged GPR84 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase complementation assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.6b01593
3218 1550 None 95 Human Binding pEC50 = 6.4 6.4 - 1
Agonist activity at human PK-tagged GPR84 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase complementation assayAgonist activity at human PK-tagged GPR84 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase complementation assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.6b01593
CHEMBL221137 1550 None 95 Human Binding pEC50 = 6.4 6.4 - 1
Agonist activity at human PK-tagged GPR84 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase complementation assayAgonist activity at human PK-tagged GPR84 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase complementation assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.6b01593
16064 171042 None 71 Human Binding pEC50 = 6.4 6.4 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCC(O)CC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL4456892 171042 None 71 Human Binding pEC50 = 6.4 6.4 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCC(O)CC(=O)O 10.1021/acs.jmedchem.9b01339
9882204 159486 None 17 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 282 2 2 0 4.5 Fc1ccc2[nH]cc(Cc3c[nH]c4ccc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4101728 159486 None 17 Human Binding pEC50 = 5.4 5.4 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 282 2 2 0 4.5 Fc1ccc2[nH]cc(Cc3c[nH]c4ccc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
5533 3941 None 104 Human Binding pEC50 = 5.4 5.4 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
8180 3941 None 104 Human Binding pEC50 = 5.4 5.4 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL108030 3941 None 104 Human Binding pEC50 = 5.4 5.4 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
1563 72913 None 58 Human Binding pEC50 = 5.4 5.4 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCCC(O)C(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL2004471 72913 None 58 Human Binding pEC50 = 5.4 5.4 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCCC(O)C(=O)O 10.1021/acs.jmedchem.9b01339
5288266 16440 None 47 Human Binding pEC50 = 6.3 6.3 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCC[C@@H](O)CC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL1232858 16440 None 47 Human Binding pEC50 = 6.3 6.3 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCC[C@@H](O)CC(=O)O 10.1021/acs.jmedchem.9b01339
102583156 158915 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 276 3 2 1 4.2 COc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.9b01339
CHEMBL4095532 158915 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 276 3 2 1 4.2 COc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.9b01339
11212 165 None 0 Human Binding pEC50 = 5.3 5.3 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as induction of beta-arrestin recruitment by chemiluminescence PathHunter assayAgonist activity at human GPR84 expressed in CHO cells assessed as induction of beta-arrestin recruitment by chemiluminescence PathHunter assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
127045422 165 None 0 Human Binding pEC50 = 5.3 5.3 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as induction of beta-arrestin recruitment by chemiluminescence PathHunter assayAgonist activity at human GPR84 expressed in CHO cells assessed as induction of beta-arrestin recruitment by chemiluminescence PathHunter assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3828298 165 None 0 Human Binding pEC50 = 5.3 5.3 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as induction of beta-arrestin recruitment by chemiluminescence PathHunter assayAgonist activity at human GPR84 expressed in CHO cells assessed as induction of beta-arrestin recruitment by chemiluminescence PathHunter assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
11209 1550 None 95 Human Binding pEC50 = 5.3 5.3 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
3218 1550 None 95 Human Binding pEC50 = 5.3 5.3 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL221137 1550 None 95 Human Binding pEC50 = 5.3 5.3 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter assay
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
11212 165 None 0 Human Binding pEC50 = 6.3 6.3 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
127045422 165 None 0 Human Binding pEC50 = 6.3 6.3 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3828298 165 None 0 Human Binding pEC50 = 6.3 6.3 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assay
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
137649817 157409 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 318 2 2 0 4.8 Fc1cc2[nH]cc(Cc3c[nH]c4cc(F)c(F)cc34)c2cc1F 10.1021/acs.jmedchem.9b01339
CHEMBL4078546 157409 None 0 Human Binding pEC50 = 7.3 7.3 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 318 2 2 0 4.8 Fc1cc2[nH]cc(Cc3c[nH]c4cc(F)c(F)cc34)c2cc1F 10.1021/acs.jmedchem.9b01339
11210 3210 None 1 Human Binding pEC50 = 6.3 6.3 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 265 4 3 3 1.4 Clc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
146025748 3210 None 1 Human Binding pEC50 = 6.3 6.3 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 265 4 3 3 1.4 Clc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4538049 3210 None 1 Human Binding pEC50 = 6.3 6.3 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 265 4 3 3 1.4 Clc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
102219035 159385 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 314 2 2 0 5.5 Clc1ccc2c(Cc3c[nH]c4cc(Cl)ccc34)c[nH]c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4100658 159385 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 314 2 2 0 5.5 Clc1ccc2c(Cc3c[nH]c4cc(Cl)ccc34)c[nH]c2c1 10.1021/acs.jmedchem.6b01593
137643701 158276 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4088884 158276 None 0 Human Binding pEC50 = 5.3 5.3 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 318 2 2 0 4.8 Fc1cc(F)c2[nH]cc(Cc3c[nH]c4c(F)cc(F)cc34)c2c1 10.1021/acs.jmedchem.6b01593
10201214 93575 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 402 2 2 0 5.8 Brc1ccc2[nH]cc(Cc3c[nH]c4ccc(Br)cc34)c2c1 10.1021/acs.jmedchem.9b01339
CHEMBL246504 93575 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 402 2 2 0 5.8 Brc1ccc2[nH]cc(Cc3c[nH]c4ccc(Br)cc34)c2c1 10.1021/acs.jmedchem.9b01339
11211 4152 None 29 Human Binding pEC50 = 6.2 6.2 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment measured after 20 mins by luciferase reporter gene assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment measured after 20 mins by luciferase reporter gene assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
1912564 4152 None 29 Human Binding pEC50 = 6.2 6.2 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment measured after 20 mins by luciferase reporter gene assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment measured after 20 mins by luciferase reporter gene assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827756 4152 None 29 Human Binding pEC50 = 6.2 6.2 - 1
Agonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment measured after 20 mins by luciferase reporter gene assayAgonist activity at recombinant human GPR84 expressed in HEK293 cells assessed as beta-arrestin 2 recruitment measured after 20 mins by luciferase reporter gene assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
137635702 156045 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 282 2 2 0 4.5 Fc1cccc2c(Cc3c[nH]c4c(F)cccc34)c[nH]c12 10.1021/acs.jmedchem.6b01593
CHEMBL4062512 156045 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 282 2 2 0 4.5 Fc1cccc2c(Cc3c[nH]c4c(F)cccc34)c[nH]c12 10.1021/acs.jmedchem.6b01593
10266133 156166 None 5 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 288 4 2 0 5.6 CCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.6b01593
CHEMBL4063898 156166 None 5 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 288 4 2 0 5.6 CCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.6b01593
135373094 1356 None 95 Human Binding pEC50 = 5.2 5.2 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
2969 1356 None 95 Human Binding pEC50 = 5.2 5.2 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
5532 1356 None 95 Human Binding pEC50 = 5.2 5.2 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
CHEMBL107498 1356 None 95 Human Binding pEC50 = 5.2 5.2 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
DB03600 1356 None 95 Human Binding pEC50 = 5.2 5.2 - 1
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.6b01593
137635702 156045 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 282 2 2 0 4.5 Fc1cccc2c(Cc3c[nH]c4c(F)cccc34)c[nH]c12 10.1021/acs.jmedchem.9b01339
CHEMBL4062512 156045 None 0 Human Binding pEC50 = 7.2 7.2 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 282 2 2 0 4.5 Fc1cccc2c(Cc3c[nH]c4c(F)cccc34)c[nH]c12 10.1021/acs.jmedchem.9b01339
102583156 158915 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 276 3 2 1 4.2 COc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4095532 158915 None 0 Human Binding pEC50 = 5.2 5.2 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 276 3 2 1 4.2 COc1ccc2[nH]cc(Cc3c[nH]c4ccccc34)c2c1 10.1021/acs.jmedchem.6b01593
11005 2692 None 107 Human Binding pEC50 = 5.2 5.2 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2806 2692 None 107 Human Binding pEC50 = 5.2 5.2 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL111077 2692 None 107 Human Binding pEC50 = 5.2 5.2 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB08231 2692 None 107 Human Binding pEC50 = 5.2 5.2 - 1
Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assayAgonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
11507535 159296 None 1 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 288 3 2 0 5.4 CC(C)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.6b01593
CHEMBL4099626 159296 None 1 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 288 3 2 0 5.4 CC(C)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.6b01593
72711216 157763 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 282 2 2 0 4.5 Fc1ccc2c(Cc3c[nH]c4cc(F)ccc34)c[nH]c2c1 10.1021/acs.jmedchem.6b01593
CHEMBL4082668 157763 None 0 Human Binding pEC50 = 5.1 5.1 - 0
Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assayAgonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay
ChEMBL 282 2 2 0 4.5 Fc1ccc2c(Cc3c[nH]c4cc(F)ccc34)c[nH]c2c1 10.1021/acs.jmedchem.6b01593
11211 4152 None 29 Human Binding pEC50 = 5.1 5.1 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
1912564 4152 None 29 Human Binding pEC50 = 5.1 5.1 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
CHEMBL3827756 4152 None 29 Human Binding pEC50 = 5.1 5.1 - 1
Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assayAgonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assay
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.0c01378
137654126 159011 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 318 2 2 0 4.8 Fc1ccc2[nH]cc(Cc3c[nH]c4ccc(F)c(F)c34)c2c1F 10.1021/acs.jmedchem.9b01339
CHEMBL4096571 159011 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting methodPositive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method
ChEMBL 318 2 2 0 4.8 Fc1ccc2[nH]cc(Cc3c[nH]c4ccc(F)c(F)c34)c2c1F 10.1021/acs.jmedchem.9b01339
9878666 93510 None 2 Human Binding pIC50 = 4.9 4.9 - 0
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 274 2 0 2 4.3 Cn1cc(Cc2cn(C)c3ccccc23)c2ccccc21 10.1021/acs.jmedchem.9b01339
CHEMBL246297 93510 None 2 Human Binding pIC50 = 4.9 4.9 - 0
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 274 2 0 2 4.3 Cn1cc(Cc2cn(C)c3ccccc23)c2ccccc21 10.1021/acs.jmedchem.9b01339
78319081 183700 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Antagonist activity at human C-terminal GFP10-fused GPR84 expressed in HEK293 cells co-expressing Rluc8-tagged Galphai2/GFP10-tagged Ggamma2/Gbeta1 assessed as inhibition of embelin-induced Galphai activation incubated for 10 mins by BRET assayAntagonist activity at human C-terminal GFP10-fused GPR84 expressed in HEK293 cells co-expressing Rluc8-tagged Galphai2/GFP10-tagged Ggamma2/Gbeta1 assessed as inhibition of embelin-induced Galphai activation incubated for 10 mins by BRET assay
ChEMBL 276 10 1 1 4.8 CCCCCc1cc(CCCCC)cc(CC(=O)O)c1 10.1021/acs.jmedchem.0c01378
CHEMBL4762090 183700 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Antagonist activity at human C-terminal GFP10-fused GPR84 expressed in HEK293 cells co-expressing Rluc8-tagged Galphai2/GFP10-tagged Ggamma2/Gbeta1 assessed as inhibition of embelin-induced Galphai activation incubated for 10 mins by BRET assayAntagonist activity at human C-terminal GFP10-fused GPR84 expressed in HEK293 cells co-expressing Rluc8-tagged Galphai2/GFP10-tagged Ggamma2/Gbeta1 assessed as inhibition of embelin-induced Galphai activation incubated for 10 mins by BRET assay
ChEMBL 276 10 1 1 4.8 CCCCCc1cc(CCCCC)cc(CC(=O)O)c1 10.1021/acs.jmedchem.0c01378
CHEMBL4803197 183700 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Antagonist activity at human C-terminal GFP10-fused GPR84 expressed in HEK293 cells co-expressing Rluc8-tagged Galphai2/GFP10-tagged Ggamma2/Gbeta1 assessed as inhibition of embelin-induced Galphai activation incubated for 10 mins by BRET assayAntagonist activity at human C-terminal GFP10-fused GPR84 expressed in HEK293 cells co-expressing Rluc8-tagged Galphai2/GFP10-tagged Ggamma2/Gbeta1 assessed as inhibition of embelin-induced Galphai activation incubated for 10 mins by BRET assay
ChEMBL 276 10 1 1 4.8 CCCCCc1cc(CCCCC)cc(CC(=O)O)c1 10.1021/acs.jmedchem.0c01378
10266133 156166 None 5 Human Binding pIC50 = 4.7 4.7 - 0
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 288 4 2 0 5.6 CCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.9b01339
CHEMBL4063898 156166 None 5 Human Binding pIC50 = 4.7 4.7 - 0
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 288 4 2 0 5.6 CCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.9b01339
102219035 159385 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 314 2 2 0 5.5 Clc1ccc2c(Cc3c[nH]c4cc(Cl)ccc34)c[nH]c2c1 10.1021/acs.jmedchem.9b01339
CHEMBL4100658 159385 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 314 2 2 0 5.5 Clc1ccc2c(Cc3c[nH]c4cc(Cl)ccc34)c[nH]c2c1 10.1021/acs.jmedchem.9b01339
11150029 158006 None 2 Human Binding pIC50 = 4.3 4.3 - 0
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 274 3 2 0 5.2 CCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.9b01339
CHEMBL4085470 158006 None 2 Human Binding pIC50 = 4.3 4.3 - 0
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 274 3 2 0 5.2 CCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 10.1021/acs.jmedchem.9b01339
162672882 183105 None 0 Human Binding pKd = 9.6 9.6 - 1
Binding affinity to recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membrane incubated for 1 hr by liquid scintillation spectrometryBinding affinity to recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membrane incubated for 1 hr by liquid scintillation spectrometry
ChEMBL 440 8 0 7 3.5 O=c1nc(OCCOc2cnccn2)cc2n1CCc1cc(CCc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL4742704 183105 None 0 Human Binding pKd = 9.6 9.6 - 1
Binding affinity to recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membrane incubated for 1 hr by liquid scintillation spectrometryBinding affinity to recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membrane incubated for 1 hr by liquid scintillation spectrometry
ChEMBL 440 8 0 7 3.5 O=c1nc(OCCOc2cnccn2)cc2n1CCc1cc(CCc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
CHEMBL4794652 183105 None 0 Human Binding pKd = 9.6 9.6 - 1
Binding affinity to recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membrane incubated for 1 hr by liquid scintillation spectrometryBinding affinity to recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membrane incubated for 1 hr by liquid scintillation spectrometry
ChEMBL 440 8 0 7 3.5 O=c1nc(OCCOc2cnccn2)cc2n1CCc1cc(CCc3ccccc3)ccc1-2 10.1021/acs.jmedchem.0c01378
11211 4152 None 29 Human Binding pKi = 9.7 9.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
1912564 4152 None 29 Human Binding pKi = 9.7 9.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827756 4152 None 29 Human Binding pKi = 9.7 9.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 228 6 2 4 2.1 CCCCCCSc1nc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
133081959 3211 None 1 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 309 4 3 3 1.5 Brc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
9871 3211 None 1 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 309 4 3 3 1.5 Brc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4444010 3211 None 1 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 309 4 3 3 1.5 Brc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
127045103 141121 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 276 6 2 5 3.0 Oc1cc(O)nc(SCCCCc2ccccc2)n1 10.1021/acs.jmedchem.9b01339
CHEMBL3827310 141121 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 276 6 2 5 3.0 Oc1cc(O)nc(SCCCCc2ccccc2)n1 10.1021/acs.jmedchem.9b01339
309844 206527 None 4 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 259 6 3 5 2.3 Oc1cc(NCCCCc2ccccc2)nc(O)n1 10.1021/acs.jmedchem.9b01339
CHEMBL88536 206527 None 4 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 259 6 3 5 2.3 Oc1cc(NCCCCc2ccccc2)nc(O)n1 10.1021/acs.jmedchem.9b01339
146025749 174169 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 259 5 3 3 1.3 CCc1ccc(CCNc2cc(=O)[nH]c(=O)[nH]2)cc1 10.1021/acs.jmedchem.9b01339
CHEMBL4547165 174169 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 259 5 3 3 1.3 CCc1ccc(CCNc2cc(=O)[nH]c(=O)[nH]2)cc1 10.1021/acs.jmedchem.9b01339
10354234 164 None 46 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5846 164 None 46 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3827832 164 None 46 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 239 8 3 3 1.8 CCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
11210 3210 None 1 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 265 4 3 3 1.4 Clc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
146025748 3210 None 1 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 265 4 3 3 1.4 Clc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4538049 3210 None 1 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 265 4 3 3 1.4 Clc1ccc(cc1)CCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
127045635 141207 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 262 5 2 5 2.6 Oc1cc(O)nc(SCCCc2ccccc2)n1 10.1021/acs.jmedchem.9b01339
CHEMBL3828415 141207 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 262 5 2 5 2.6 Oc1cc(O)nc(SCCCc2ccccc2)n1 10.1021/acs.jmedchem.9b01339
44349289 17028 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 267 10 3 5 3.4 CCCCCCCCCCNc1cc(O)nc(O)n1 10.1021/acs.jmedchem.9b01339
CHEMBL125436 17028 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 267 10 3 5 3.4 CCCCCCCCCCNc1cc(O)nc(O)n1 10.1021/acs.jmedchem.9b01339
146025740 171846 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 225 7 3 3 1.4 CCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4468895 171846 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 225 7 3 3 1.4 CCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
146025741 173157 None 0 Human Binding pKi = 9.0 9.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 253 9 3 3 2.2 CCCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4521587 173157 None 0 Human Binding pKi = 9.0 9.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 253 9 3 3 2.2 CCCCCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
146025746 169821 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 245 4 3 3 1.0 Cc1ccc(CCNc2cc(=O)[nH]c(=O)[nH]2)cc1 10.1021/acs.jmedchem.9b01339
CHEMBL4439640 169821 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 245 4 3 3 1.0 Cc1ccc(CCNc2cc(=O)[nH]c(=O)[nH]2)cc1 10.1021/acs.jmedchem.9b01339
146025751 175634 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 287 4 3 3 2.0 CC(C)(C)c1ccc(CCNc2cc(=O)[nH]c(=O)[nH]2)cc1 10.1021/acs.jmedchem.9b01339
CHEMBL4580884 175634 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 287 4 3 3 2.0 CC(C)(C)c1ccc(CCNc2cc(=O)[nH]c(=O)[nH]2)cc1 10.1021/acs.jmedchem.9b01339
11212 165 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
127045422 165 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL3828298 165 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 237 8 2 2 3.4 CCCCCCCCCc1cc(O)cc(=O)[nH]1 10.1021/acs.jmedchem.9b01339
308653 106895 None 9 Human Binding pKi = 8.0 8.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 231 4 3 5 1.5 Oc1cc(NCCc2ccccc2)nc(O)n1 10.1021/acs.jmedchem.9b01339
CHEMBL314575 106895 None 9 Human Binding pKi = 8.0 8.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 231 4 3 5 1.5 Oc1cc(NCCc2ccccc2)nc(O)n1 10.1021/acs.jmedchem.9b01339
5796 67 None 77 Human Binding pKi = 4 4.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 160 6 2 2 1.4 CCCCCCC(C(=O)O)O 10.1021/acs.jmedchem.9b01339
94180 67 None 77 Human Binding pKi = 4 4.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 160 6 2 2 1.4 CCCCCCC(C(=O)O)O 10.1021/acs.jmedchem.9b01339
CHEMBL4447980 67 None 77 Human Binding pKi = 4 4.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 160 6 2 2 1.4 CCCCCCC(C(=O)O)O 10.1021/acs.jmedchem.9b01339
5533 3941 None 104 Human Binding pKi = 7.0 7.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
8180 3941 None 104 Human Binding pKi = 7.0 7.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL108030 3941 None 104 Human Binding pKi = 7.0 7.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 186 9 1 1 3.6 CCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
146025747 174927 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 249 4 3 3 0.9 O=c1cc(NCCc2ccc(F)cc2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4565153 174927 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 249 4 3 3 0.9 O=c1cc(NCCc2ccc(F)cc2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5850 100 None 63 Human Binding pKi = 7.0 7.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
94216 100 None 63 Human Binding pKi = 7.0 7.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
CHEMBL4288936 100 None 63 Human Binding pKi = 7.0 7.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 216 10 2 2 3.0 CCCCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
70521246 172798 None 0 Human Binding pKi = 5.9 5.9 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 240 6 2 4 0.8 CCCCCCOC(=O)c1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4513706 172798 None 0 Human Binding pKi = 5.9 5.9 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 240 6 2 4 0.8 CCCCCCOC(=O)c1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
155564247 175413 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 312 2 2 4 0.9 O=c1cc(N2CCN(C3CCc4ccccc43)CC2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4575870 175413 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 312 2 2 4 0.9 O=c1cc(N2CCN(C3CCc4ccccc43)CC2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
136342308 170002 None 0 Human Binding pKi = 6.8 6.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 256 7 2 5 2.6 CCCCCCSc1nc(O)cc(C(=O)O)n1 10.1021/acs.jmedchem.9b01339
CHEMBL4442407 170002 None 0 Human Binding pKi = 6.8 6.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 256 7 2 5 2.6 CCCCCCSc1nc(O)cc(C(=O)O)n1 10.1021/acs.jmedchem.9b01339
110698284 174458 None 2 Human Binding pKi = 5.8 5.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 225 5 3 3 -0.0 CCCCCNC(=O)c1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4554014 174458 None 2 Human Binding pKi = 5.8 5.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 225 5 3 3 -0.0 CCCCCNC(=O)c1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
110698276 170638 None 2 Human Binding pKi = 5.8 5.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 273 5 3 3 0.4 O=C(NCCCc1ccccc1)c1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4451263 170638 None 2 Human Binding pKi = 5.8 5.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 273 5 3 3 0.4 O=C(NCCCc1ccccc1)c1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
135373094 1356 None 95 Human Binding pKi = 5.8 5.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2969 1356 None 95 Human Binding pKi = 5.8 5.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5532 1356 None 95 Human Binding pKi = 5.8 5.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107498 1356 None 95 Human Binding pKi = 5.8 5.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03600 1356 None 95 Human Binding pKi = 5.8 5.8 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 172 8 1 1 3.2 CCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
146025759 172961 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 285 3 2 3 1.5 O=c1cc(N2CCC(Cc3ccccc3)CC2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4517538 172961 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 285 3 2 3 1.5 O=c1cc(N2CCC(Cc3ccccc3)CC2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
146025763 169509 None 0 Human Binding pKi = 6.7 6.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 274 6 3 5 1.5 O=Nc1c(NCCCc2ccccc2)[nH]c(=O)[nH]c1=O 10.1021/acs.jmedchem.9b01339
CHEMBL4434708 169509 None 0 Human Binding pKi = 6.7 6.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 274 6 3 5 1.5 O=Nc1c(NCCCc2ccccc2)[nH]c(=O)[nH]c1=O 10.1021/acs.jmedchem.9b01339
12530 5789 None 92 Human Binding pKi = 5.7 5.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 214 11 1 1 4.4 CCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL107874 5789 None 92 Human Binding pKi = 5.7 5.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 214 11 1 1 4.4 CCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
135372298 110488 None 95 Human Binding pKi = 4.7 4.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 144 6 1 1 2.4 CCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
379 110488 None 95 Human Binding pKi = 4.7 4.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 144 6 1 1 2.4 CCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL324846 110488 None 95 Human Binding pKi = 4.7 4.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 144 6 1 1 2.4 CCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
309859 173434 None 3 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 261 6 3 4 0.9 O=c1cc(NCCCOc2ccccc2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4528940 173434 None 3 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 261 6 3 4 0.9 O=c1cc(NCCCOc2ccccc2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
146025758 175215 None 0 Human Binding pKi = 8.6 8.6 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 299 4 3 3 2.0 O=c1cc(NCCc2ccc(Cl)cc2Cl)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4571353 175215 None 0 Human Binding pKi = 8.6 8.6 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 299 4 3 3 2.0 O=c1cc(NCCc2ccc(Cl)cc2Cl)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
155513228 169743 None 0 Human Binding pKi = 8.6 8.6 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 282 4 2 4 2.5 O=c1cc(O)nc(SCCc2ccc(Cl)cc2)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4438595 169743 None 0 Human Binding pKi = 8.6 8.6 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 282 4 2 4 2.5 O=c1cc(O)nc(SCCc2ccc(Cl)cc2)[nH]1 10.1021/acs.jmedchem.9b01339
10717 3208 None 4 Human Binding pKi = 8.5 8.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
44349321 3208 None 4 Human Binding pKi = 8.5 8.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL124977 3208 None 4 Human Binding pKi = 8.5 8.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 211 6 3 3 1.1 CCCCCCNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
3893 2285 None 98 Human Binding pKi = 5.7 5.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
4642 2285 None 98 Human Binding pKi = 5.7 5.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
5534 2285 None 98 Human Binding pKi = 5.7 5.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL108766 2285 None 98 Human Binding pKi = 5.7 5.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB03017 2285 None 98 Human Binding pKi = 5.7 5.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 200 10 1 1 4.0 CCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
155525380 171011 None 0 Human Binding pKi = 6.7 6.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 289 6 3 3 1.8 CCCCCCNc1[nH]c(=O)[nH]c(=O)c1Br 10.1021/acs.jmedchem.9b01339
CHEMBL4456565 171011 None 0 Human Binding pKi = 6.7 6.7 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 289 6 3 3 1.8 CCCCCCNc1[nH]c(=O)[nH]c(=O)c1Br 10.1021/acs.jmedchem.9b01339
11209 1550 None 95 Human Binding pKi = 7.6 7.6 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
3218 1550 None 95 Human Binding pKi = 7.6 7.6 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL221137 1550 None 95 Human Binding pKi = 7.6 7.6 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 294 10 2 4 4.3 CCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O 10.1021/acs.jmedchem.9b01339
11005 2692 None 107 Human Binding pKi = 5.6 5.6 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
2806 2692 None 107 Human Binding pKi = 5.6 5.6 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL111077 2692 None 107 Human Binding pKi = 5.6 5.6 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
DB08231 2692 None 107 Human Binding pKi = 5.6 5.6 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 228 12 1 1 4.8 CCCCCCCCCCCCCC(=O)O 10.1021/acs.jmedchem.9b01339
146025742 170928 None 0 Human Binding pKi = 6.6 6.6 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 241 8 4 4 0.4 O=c1cc(NCCCCCCCO)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4455292 170928 None 0 Human Binding pKi = 6.6 6.6 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 241 8 4 4 0.4 O=c1cc(NCCCCCCCO)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
308775 173417 None 1 Human Binding pKi = 8.5 8.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 247 5 3 4 0.6 O=c1cc(NCCOc2ccccc2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4528577 173417 None 1 Human Binding pKi = 8.5 8.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 247 5 3 4 0.6 O=c1cc(NCCOc2ccccc2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
155559672 174834 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 326 4 2 4 2.6 O=c1cc(O)nc(SCCc2ccc(Br)cc2)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4562761 174834 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 326 4 2 4 2.6 O=c1cc(O)nc(SCCc2ccc(Br)cc2)[nH]1 10.1021/acs.jmedchem.9b01339
155549030 173665 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 262 4 2 4 2.1 Cc1ccc(CCSc2nc(O)cc(=O)[nH]2)cc1 10.1021/acs.jmedchem.9b01339
CHEMBL4534827 173665 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 262 4 2 4 2.1 Cc1ccc(CCSc2nc(O)cc(=O)[nH]2)cc1 10.1021/acs.jmedchem.9b01339
146025745 175094 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 253 8 2 3 1.9 CCCCCCCCN(C)c1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4568775 175094 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 253 8 2 3 1.9 CCCCCCCCN(C)c1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
140898903 171768 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 266 4 2 4 1.9 O=c1cc(O)nc(SCCc2ccc(F)cc2)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4467630 171768 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 266 4 2 4 1.9 O=c1cc(O)nc(SCCc2ccc(F)cc2)[nH]1 10.1021/acs.jmedchem.9b01339
146025754 171832 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 309 4 3 3 1.5 O=c1cc(NCCc2cccc(Br)c2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4468678 171832 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 309 4 3 3 1.5 O=c1cc(NCCc2cccc(Br)c2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
10171 1811 None 20 Human Binding pKi = 7.5 7.5 - 1
Displacement of [3H]-9-(2-phenylethyl)-2-(2-pyrazin-2-yloxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one from recombinant FLAG-tagged GPR84 (unknown origin) expressed in T-REx-293 cells co-expressing Galphai2 incubated for 1 hr by liquid scintillation counting analysisDisplacement of [3H]-9-(2-phenylethyl)-2-(2-pyrazin-2-yloxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one from recombinant FLAG-tagged GPR84 (unknown origin) expressed in T-REx-293 cells co-expressing Galphai2 incubated for 1 hr by liquid scintillation counting analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.0c00272
71616860 1811 None 20 Human Binding pKi = 7.5 7.5 - 1
Displacement of [3H]-9-(2-phenylethyl)-2-(2-pyrazin-2-yloxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one from recombinant FLAG-tagged GPR84 (unknown origin) expressed in T-REx-293 cells co-expressing Galphai2 incubated for 1 hr by liquid scintillation counting analysisDisplacement of [3H]-9-(2-phenylethyl)-2-(2-pyrazin-2-yloxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one from recombinant FLAG-tagged GPR84 (unknown origin) expressed in T-REx-293 cells co-expressing Galphai2 incubated for 1 hr by liquid scintillation counting analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.0c00272
CHEMBL3716365 1811 None 20 Human Binding pKi = 7.5 7.5 - 1
Displacement of [3H]-9-(2-phenylethyl)-2-(2-pyrazin-2-yloxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one from recombinant FLAG-tagged GPR84 (unknown origin) expressed in T-REx-293 cells co-expressing Galphai2 incubated for 1 hr by liquid scintillation counting analysisDisplacement of [3H]-9-(2-phenylethyl)-2-(2-pyrazin-2-yloxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one from recombinant FLAG-tagged GPR84 (unknown origin) expressed in T-REx-293 cells co-expressing Galphai2 incubated for 1 hr by liquid scintillation counting analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.0c00272
DB15346 1811 None 20 Human Binding pKi = 7.5 7.5 - 1
Displacement of [3H]-9-(2-phenylethyl)-2-(2-pyrazin-2-yloxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one from recombinant FLAG-tagged GPR84 (unknown origin) expressed in T-REx-293 cells co-expressing Galphai2 incubated for 1 hr by liquid scintillation counting analysisDisplacement of [3H]-9-(2-phenylethyl)-2-(2-pyrazin-2-yloxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one from recombinant FLAG-tagged GPR84 (unknown origin) expressed in T-REx-293 cells co-expressing Galphai2 incubated for 1 hr by liquid scintillation counting analysis
ChEMBL 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 10.1021/acs.jmedchem.0c00272
1563 72913 None 58 Human Binding pKi = 6.5 6.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCCC(O)C(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL2004471 72913 None 58 Human Binding pKi = 6.5 6.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCCC(O)C(=O)O 10.1021/acs.jmedchem.9b01339
26612 99 None 79 Human Binding pKi = 5.5 5.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 188 8 2 2 2.2 CCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
5848 99 None 79 Human Binding pKi = 5.5 5.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 188 8 2 2 2.2 CCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
CHEMBL4448230 99 None 79 Human Binding pKi = 5.5 5.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 188 8 2 2 2.2 CCCCCCCC(CC(=O)O)O 10.1021/acs.jmedchem.9b01339
155560912 174969 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 317 8 3 3 2.6 CCCCCCCCNc1[nH]c(=O)[nH]c(=O)c1Br 10.1021/acs.jmedchem.9b01339
CHEMBL4566117 174969 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 317 8 3 3 2.6 CCCCCCCCNc1[nH]c(=O)[nH]c(=O)c1Br 10.1021/acs.jmedchem.9b01339
15549641 174591 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 212 6 1 4 2.9 CCCCCCSc1nccc(O)n1 10.1021/acs.jmedchem.9b01339
CHEMBL4557017 174591 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 212 6 1 4 2.9 CCCCCCSc1nccc(O)n1 10.1021/acs.jmedchem.9b01339
146025755 170517 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 249 4 3 3 0.9 O=c1cc(NCCc2ccccc2F)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4449633 170517 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 249 4 3 3 0.9 O=c1cc(NCCc2ccccc2F)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
146025756 173635 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 265 4 3 3 1.4 O=c1cc(NCCc2ccccc2Cl)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4534071 173635 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 265 4 3 3 1.4 O=c1cc(NCCc2ccccc2Cl)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
155564383 175353 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 316 4 2 4 2.8 O=c1cc(O)nc(SCCc2ccc(C(F)(F)F)cc2)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4574495 175353 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 316 4 2 4 2.8 O=c1cc(O)nc(SCCc2ccc(C(F)(F)F)cc2)[nH]1 10.1021/acs.jmedchem.9b01339
135412234 170045 None 17 Human Binding pKi = 5.4 5.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 226 6 1 4 3.2 CCCCCCSc1nc(C)cc(O)n1 10.1021/acs.jmedchem.9b01339
CHEMBL4442902 170045 None 17 Human Binding pKi = 5.4 5.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 226 6 1 4 3.2 CCCCCCSc1nc(C)cc(O)n1 10.1021/acs.jmedchem.9b01339
12782103 171396 None 3 Human Binding pKi = 7.4 7.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 268 9 3 5 2.2 CCCCCCCCNc1[nH]c(=O)[nH]c(=O)c1N=O 10.1021/acs.jmedchem.9b01339
CHEMBL4462370 171396 None 3 Human Binding pKi = 7.4 7.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 268 9 3 5 2.2 CCCCCCCCNc1[nH]c(=O)[nH]c(=O)c1N=O 10.1021/acs.jmedchem.9b01339
155551005 173942 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 209 5 3 3 0.8 CCC/C=C/CNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4541166 173942 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 209 5 3 3 0.8 CCC/C=C/CNc1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
146025753 172214 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 265 4 3 3 1.4 O=c1cc(NCCc2cccc(Cl)c2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4473999 172214 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 265 4 3 3 1.4 O=c1cc(NCCc2cccc(Cl)c2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
146025760 175781 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 306 2 2 4 1.0 O=c1cc(N2CCN(c3ccc(Cl)cc3)CC2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4584001 175781 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 306 2 2 4 1.0 O=c1cc(N2CCN(c3ccc(Cl)cc3)CC2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
21204487 173028 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 239 6 3 3 0.4 CCCCCCNC(=O)c1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4518826 173028 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 239 6 3 3 0.4 CCCCCCNC(=O)c1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
5288266 16440 None 47 Human Binding pKi = 6.3 6.3 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCC[C@@H](O)CC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL1232858 16440 None 47 Human Binding pKi = 6.3 6.3 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCC[C@@H](O)CC(=O)O 10.1021/acs.jmedchem.9b01339
121205397 171697 None 10 Human Binding pKi = 7.3 7.3 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 237 4 3 4 0.8 O=c1cc(NCCc2cccs2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4466657 171697 None 10 Human Binding pKi = 7.3 7.3 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 237 4 3 4 0.8 O=c1cc(NCCc2cccs2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
86293760 171952 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 270 4 4 3 1.2 O=c1cc(NCCc2c[nH]c3ccccc23)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4470574 171952 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 270 4 4 3 1.2 O=c1cc(NCCc2c[nH]c3ccccc23)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
16064 171042 None 71 Human Binding pKi = 6.3 6.3 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCC(O)CC(=O)O 10.1021/acs.jmedchem.9b01339
CHEMBL4456892 171042 None 71 Human Binding pKi = 6.3 6.3 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 244 12 2 2 3.7 CCCCCCCCCCCC(O)CC(=O)O 10.1021/acs.jmedchem.9b01339
146025762 175364 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 254 8 3 5 1.8 CCCCCCCNc1[nH]c(=O)[nH]c(=O)c1N=O 10.1021/acs.jmedchem.9b01339
CHEMBL4574715 175364 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 254 8 3 5 1.8 CCCCCCCNc1[nH]c(=O)[nH]c(=O)c1N=O 10.1021/acs.jmedchem.9b01339
146025744 170701 None 0 Human Binding pKi = 8.2 8.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 225 6 2 3 1.1 CCCCCCN(C)c1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4451909 170701 None 0 Human Binding pKi = 8.2 8.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 225 6 2 3 1.1 CCCCCCN(C)c1cc(=O)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
155526533 171188 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 336 3 2 4 1.5 O=c1cc(N2CCN(Cc3cccc4ccccc34)CC2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4459188 171188 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 336 3 2 4 1.5 O=c1cc(N2CCN(Cc3cccc4ccccc34)CC2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
146025752 172255 None 0 Human Binding pKi = 8.0 8.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 249 4 3 3 0.9 O=c1cc(NCCc2cccc(F)c2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
CHEMBL4474487 172255 None 0 Human Binding pKi = 8.0 8.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 249 4 3 3 0.9 O=c1cc(NCCc2cccc(F)c2)[nH]c(=O)[nH]1 10.1021/acs.jmedchem.9b01339
309900 16713 None 4 Human Binding pKi = 7.0 7.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 197 5 3 5 1.5 CCCCCNc1cc(O)nc(O)n1 10.1021/acs.jmedchem.9b01339
CHEMBL124310 16713 None 4 Human Binding pKi = 7.0 7.0 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
ChEMBL 197 5 3 5 1.5 CCCCCNc1cc(O)nc(O)n1 10.1021/acs.jmedchem.9b01339
10171 1811 None 20 Human Binding pIC50 = 9 9.0 - 1
Binned data from [<sup>35</sup>S] GTP&gamma;S binding experiments using menbranes from cell that stably express GPR84.Binned data from [<sup>35</sup>S] GTP&gamma;S binding experiments using menbranes from cell that stably express GPR84.
Guide to Pharmacology 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 None
71616860 1811 None 20 Human Binding pIC50 = 9 9.0 - 1
Binned data from [<sup>35</sup>S] GTP&gamma;S binding experiments using menbranes from cell that stably express GPR84.Binned data from [<sup>35</sup>S] GTP&gamma;S binding experiments using menbranes from cell that stably express GPR84.
Guide to Pharmacology 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 None
CHEMBL3716365 1811 None 20 Human Binding pIC50 = 9 9.0 - 1
Binned data from [<sup>35</sup>S] GTP&gamma;S binding experiments using menbranes from cell that stably express GPR84.Binned data from [<sup>35</sup>S] GTP&gamma;S binding experiments using menbranes from cell that stably express GPR84.
Guide to Pharmacology 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 None
DB15346 1811 None 20 Human Binding pIC50 = 9 9.0 - 1
Binned data from [<sup>35</sup>S] GTP&gamma;S binding experiments using menbranes from cell that stably express GPR84.Binned data from [<sup>35</sup>S] GTP&gamma;S binding experiments using menbranes from cell that stably express GPR84.
Guide to Pharmacology 378 3 0 6 2.0 O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1 None
135372298 110488 None 95 Human Binding pKi = 8.3 8.3 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
Drug Central 144 6 1 1 2.4 CCCCCCCC(=O)O None
379 110488 None 95 Human Binding pKi = 8.3 8.3 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
Drug Central 144 6 1 1 2.4 CCCCCCCC(=O)O None
CHEMBL324846 110488 None 95 Human Binding pKi = 8.3 8.3 - 1
Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting methodDisplacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method
Drug Central 144 6 1 1 2.4 CCCCCCCC(=O)O None