Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
118727607 124284 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 410 6 1 2 5.8 NC1(CN(C(=O)[C@@H]2C[C@H]2c2ccccc2)c2ccc(-c3ccccc3)cc2)CCCC1 10.1016/j.bmcl.2015.02.038
CHEMBL3400199 124284 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 410 6 1 2 5.8 NC1(CN(C(=O)[C@@H]2C[C@H]2c2ccccc2)c2ccc(-c3ccccc3)cc2)CCCC1 10.1016/j.bmcl.2015.02.038
118730169 124836 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 438 7 1 2 6.4 N[C@H](CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1)C1CCCCC1 10.1016/j.bmcl.2015.02.038
CHEMBL3404056 124836 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 438 7 1 2 6.4 N[C@H](CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1)C1CCCCC1 10.1016/j.bmcl.2015.02.038
118727606 124283 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 8 1 3 4.9 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400198 124283 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 8 1 3 4.9 CO[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727605 124282 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 398 7 1 2 5.5 CC(C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400197 124282 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 398 7 1 2 5.5 CC(C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118730162 124829 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 9 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)C(C)Cc1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3404049 124829 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 9 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)C(C)Cc1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727608 124285 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 384 6 1 2 5.2 CC(C)(N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400200 124285 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 384 6 1 2 5.2 CC(C)(N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118730167 124834 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC[C@@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3404054 124834 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC[C@@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118730168 124835 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 452 8 1 2 6.8 N[C@@H](CC1CCCCC1)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3404055 124835 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 452 8 1 2 6.8 N[C@@H](CC1CCCCC1)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118730164 124831 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3404051 124831 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727610 124287 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 410 6 1 2 5.5 O=C([C@@H]1C[C@H]1c1ccccc1)N(CC1CCCNC1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400202 124287 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 410 6 1 2 5.5 O=C([C@@H]1C[C@H]1c1ccccc1)N(CC1CCCNC1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
10031 10185 9 None 2 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
134813902 10185 9 None 2 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL4595209 10185 9 None 2 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
51356430 124771 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403768 124771 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356141 124783 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 438 11 1 4 4.8 CCCC(C)COc1ccc([C@H](CN2CCOCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403783 124783 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 438 11 1 4 4.8 CCCC(C)COc1ccc([C@H](CN2CCOCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355601 140468 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3714989 140468 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355320 140496 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 438 14 2 3 6.1 CCCC(C)COc1ccc([C@H](CNCC(C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715058 140496 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 438 14 2 3 6.1 CCCC(C)COc1ccc([C@H](CNCC(C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356142 140518 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 369 9 2 3 4.5 CC[C@H](C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@@H](C)O)cc1 nan
CHEMBL3715126 140518 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 369 9 2 3 4.5 CC[C@H](C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@@H](C)O)cc1 nan
51355319 140533 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715177 140533 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356138 140560 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 425 13 3 4 4.4 CCCC(C)COc1ccc([C@H](CNC[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715294 140560 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 425 13 3 4 4.4 CCCC(C)COc1ccc([C@H](CNC[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
58466420 140600 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 385 11 3 4 3.4 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CO)c2ccccc2)cc1 nan
CHEMBL3715473 140600 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 385 11 3 4 3.4 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CO)c2ccccc2)cc1 nan
51356137 140639 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2cccnc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715603 140639 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2cccnc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355600 140645 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715622 140645 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356431 140750 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 448 13 3 4 5.0 CCCC(C)COc1ccc([C@H](CNCc2cc[nH]n2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715982 140750 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 448 13 3 4 5.0 CCCC(C)COc1ccc([C@H](CNCc2cc[nH]n2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355324 140773 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 nan
CHEMBL3716055 140773 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 nan
51355879 140847 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 497 13 3 3 6.7 CCCC(C)COc1ccc([C@H](CNCc2c[nH]c3ccccc23)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716282 140847 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 497 13 3 3 6.7 CCCC(C)COc1ccc([C@H](CNCc2c[nH]c3ccccc23)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
58466410 140963 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 451 11 1 4 4.7 CCCC(C)COc1ccc(C(CN2CCN(C)CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716700 140963 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 451 11 1 4 4.7 CCCC(C)COc1ccc(C(CN2CCN(C)CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355602 141145 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 465 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)C2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717324 141145 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 465 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)C2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355878 141197 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 483 14 3 5 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)OC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717488 141197 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 483 14 3 5 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)OC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355882 141202 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 522 14 3 6 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)Cc2cscn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717512 141202 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 522 14 3 6 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)Cc2cscn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355321 141236 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717617 141236 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355881 141271 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717750 141271 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355322 141298 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccncc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717835 141298 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccncc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355597 141335 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 479 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717978 141335 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 479 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
58466403 141578 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 452 13 2 4 5.1 CCCC(C)COc1ccc([C@H](CNCC2CCOC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718752 141578 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 452 13 2 4 5.1 CCCC(C)COc1ccc([C@H](CNCC2CCOC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355599 141674 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 396 12 2 3 5.1 CCCNC[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OC[C@@H](C)CC)cc1 nan
CHEMBL3719078 141674 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 396 12 2 3 5.1 CCCNC[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OC[C@@H](C)CC)cc1 nan
51356430 124771 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403768 124771 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356141 124783 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 438 11 1 4 4.8 CCCC(C)COc1ccc([C@H](CN2CCOCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403783 124783 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 438 11 1 4 4.8 CCCC(C)COc1ccc([C@H](CN2CCOCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355601 140468 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3714989 140468 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355320 140496 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 438 14 2 3 6.1 CCCC(C)COc1ccc([C@H](CNCC(C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715058 140496 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 438 14 2 3 6.1 CCCC(C)COc1ccc([C@H](CNCC(C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356142 140518 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 369 9 2 3 4.5 CC[C@H](C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@@H](C)O)cc1 nan
CHEMBL3715126 140518 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 369 9 2 3 4.5 CC[C@H](C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@@H](C)O)cc1 nan
51355319 140533 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715177 140533 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356138 140560 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 425 13 3 4 4.4 CCCC(C)COc1ccc([C@H](CNC[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715294 140560 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 425 13 3 4 4.4 CCCC(C)COc1ccc([C@H](CNC[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
58466420 140600 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 385 11 3 4 3.4 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CO)c2ccccc2)cc1 nan
CHEMBL3715473 140600 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 385 11 3 4 3.4 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CO)c2ccccc2)cc1 nan
51356137 140639 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2cccnc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715603 140639 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2cccnc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355600 140645 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715622 140645 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356431 140750 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 448 13 3 4 5.0 CCCC(C)COc1ccc([C@H](CNCc2cc[nH]n2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715982 140750 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 448 13 3 4 5.0 CCCC(C)COc1ccc([C@H](CNCc2cc[nH]n2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355324 140773 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 nan
CHEMBL3716055 140773 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 nan
51355879 140847 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 497 13 3 3 6.7 CCCC(C)COc1ccc([C@H](CNCc2c[nH]c3ccccc23)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716282 140847 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 497 13 3 3 6.7 CCCC(C)COc1ccc([C@H](CNCc2c[nH]c3ccccc23)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
58466410 140963 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 11 1 4 4.7 CCCC(C)COc1ccc(C(CN2CCN(C)CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716700 140963 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 11 1 4 4.7 CCCC(C)COc1ccc(C(CN2CCN(C)CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355602 141145 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 465 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)C2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717324 141145 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 465 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)C2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355878 141197 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 483 14 3 5 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)OC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717488 141197 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 483 14 3 5 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)OC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355882 141202 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 522 14 3 6 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)Cc2cscn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717512 141202 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 522 14 3 6 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)Cc2cscn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355321 141236 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717617 141236 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355881 141271 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717750 141271 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355322 141298 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccncc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717835 141298 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccncc2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355597 141335 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 479 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717978 141335 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 479 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
58466403 141578 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 452 13 2 4 5.1 CCCC(C)COc1ccc([C@H](CNCC2CCOC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718752 141578 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 452 13 2 4 5.1 CCCC(C)COc1ccc([C@H](CNCC2CCOC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355599 141674 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 396 12 2 3 5.1 CCCNC[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OC[C@@H](C)CC)cc1 nan
CHEMBL3719078 141674 0 None - 1 Human 7.0 pEC50 = 7 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 396 12 2 3 5.1 CCCNC[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OC[C@@H](C)CC)cc1 nan
162659346 188097 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 463 10 2 5 4.6 C[C@H](C(=O)N[C@@H](C(=O)NCc1nccs1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4762642 188097 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 463 10 2 5 4.6 C[C@H](C(=O)N[C@@H](C(=O)NCc1nccs1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
118727649 124324 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccnc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400240 124324 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccnc2)cc1 10.1016/j.bmcl.2015.02.038
168279298 197826 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 433 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CN)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5187140 197826 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 433 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CN)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168279298 197826 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 433 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CN)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5187140 197826 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 433 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CN)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
118727609 124286 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 6 1 2 5.9 CC(C)(C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400201 124286 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 6 1 2 5.9 CC(C)(C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
51356430 124771 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403768 124771 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118730001 124772 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403772 124772 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
58466401 124780 0 None 5 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403780 124780 0 None 5 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3884102 124780 0 None 5 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118727684 124359 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 498 11 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CCC(=O)OC)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400275 124359 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 498 11 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CCC(=O)OC)cc2)cc1 10.1016/j.bmcl.2015.02.038
51355323 140818 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccccn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716191 140818 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccccn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355323 140818 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccccn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716191 140818 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 459 13 2 4 5.6 CCCC(C)COc1ccc([C@H](CNCc2ccccn2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
118727661 124336 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 COc1cccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2015.02.038
CHEMBL3400252 124336 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 COc1cccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2015.02.038
118727682 124357 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 2 3 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CO)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400273 124357 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 2 3 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CO)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727633 124307 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1c(F)cccc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400224 124307 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1c(F)cccc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
162651180 186967 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 11 1 5 5.1 CCCC(C)COc1ccc([C@H](Cc2nnco2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4749371 186967 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 11 1 5 5.1 CCCC(C)COc1ccc([C@H](Cc2nnco2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162651180 186967 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 11 1 5 5.1 CCCC(C)COc1ccc([C@H](Cc2nnco2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4749371 186967 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 11 1 5 5.1 CCCC(C)COc1ccc([C@H](Cc2nnco2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168282483 197523 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 6 4.3 CC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5182820 197523 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 6 4.3 CC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
58466521 7850 5 None -26 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation countingAgonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
7798 7850 5 None -26 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation countingAgonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL3401461 7850 5 None -26 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation countingAgonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
168282483 197523 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 6 4.3 CC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5182820 197523 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 6 4.3 CC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
162647665 186573 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 11 2 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4744793 186573 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 11 2 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC)cc1 10.1021/acs.jmedchem.0c01581
118730004 124776 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 385 11 2 4 4.0 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](OC)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403776 124776 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 385 11 2 4 4.0 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](OC)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118727677 124352 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(OC)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400268 124352 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(OC)cc2)cc1 10.1016/j.bmcl.2015.02.038
162647665 186573 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 11 2 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4744793 186573 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 11 2 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC)cc1 10.1021/acs.jmedchem.0c01581
118727625 124301 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(C)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400216 124301 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(C)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727651 124326 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccsc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400242 124326 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccsc2)cc1 10.1016/j.bmcl.2015.02.038
118727654 124329 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 402 8 1 2 5.8 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(C2=CCCC2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400245 124329 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 402 8 1 2 5.8 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(C2=CCCC2)cc1 10.1016/j.bmcl.2015.02.038
118727656 124331 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 416 8 1 2 6.2 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(C2=CCCCC2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400247 124331 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 416 8 1 2 6.2 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(C2=CCCCC2)cc1 10.1016/j.bmcl.2015.02.038
118727658 124333 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 Cc1cccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2015.02.038
CHEMBL3400249 124333 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 Cc1cccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2015.02.038
118727688 124363 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 505 10 2 4 5.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(NS(C)(=O)=O)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400279 124363 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 505 10 2 4 5.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(NS(C)(=O)=O)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727693 124367 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@H]1C[C@@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400284 124367 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@H]1C[C@@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 10.1016/j.bmcl.2015.02.038
51348369 124792 1 None - 1 Human 6.9 pEC50 = 6.9 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 373 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3403792 124792 1 None - 1 Human 6.9 pEC50 = 6.9 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 373 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
51348369 124792 1 None - 1 Human 6.9 pEC50 = 6.9 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 373 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3403792 124792 1 None - 1 Human 6.9 pEC50 = 6.9 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 373 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
58466521 7850 5 None 26 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
7798 7850 5 None 26 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL3401461 7850 5 None 26 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
155524266 183278 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4454851 183278 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596750 183278 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155555152 183285 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 445 9 1 5 4.3 COc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4550415 183285 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 445 9 1 5 4.3 COc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596869 183285 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 445 9 1 5 4.3 COc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155566460 183380 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 475 9 1 3 6.5 CCCc1ccc(-c2ccc(N(C[C@@H](N)c3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4587388 183380 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 475 9 1 3 6.5 CCCc1ccc(-c2ccc(N(C[C@@H](N)c3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4597686 183380 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 475 9 1 3 6.5 CCCc1ccc(-c2ccc(N(C[C@@H](N)c3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
58466521 7850 5 None 26 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
7798 7850 5 None 26 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL3401461 7850 5 None 26 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
155524266 183278 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4454851 183278 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596750 183278 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155555152 183285 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 445 9 1 5 4.3 COc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4550415 183285 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 445 9 1 5 4.3 COc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596869 183285 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 445 9 1 5 4.3 COc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155566460 183380 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 475 9 1 3 6.5 CCCc1ccc(-c2ccc(N(C[C@@H](N)c3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4587388 183380 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 475 9 1 3 6.5 CCCc1ccc(-c2ccc(N(C[C@@H](N)c3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4597686 183380 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 475 9 1 3 6.5 CCCc1ccc(-c2ccc(N(C[C@@H](N)c3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
162667879 189184 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 389 8 2 3 4.1 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC(F)(F)C2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4785604 189184 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 389 8 2 3 4.1 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC(F)(F)C2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162667879 189184 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 389 8 2 3 4.1 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC(F)(F)C2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4785604 189184 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 389 8 2 3 4.1 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC(F)(F)C2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
168275346 197018 0 None 549 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5175064 197018 0 None 549 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
118727634 124308 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400225 124308 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727637 124311 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 8 1 4 4.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ncccn1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400228 124311 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 8 1 4 4.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ncccn1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727632 124306 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400223 124306 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727644 124319 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 433 8 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ncc(C)s1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400235 124319 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 433 8 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ncc(C)s1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727650 124325 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccncc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400241 124325 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccncc2)cc1 10.1016/j.bmcl.2015.02.038
168292704 198840 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nc(C)no2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5202571 198840 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nc(C)no2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
168292704 198840 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nc(C)no2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5202571 198840 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nc(C)no2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
86658399 148966 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 394 11 1 3 5.8 CCCC(C)COc1ccc([C@H](CN=[N+]=[N-])NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884002 148966 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 394 11 1 3 5.8 CCCC(C)COc1ccc([C@H](CN=[N+]=[N-])NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
86658399 148966 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 394 11 1 3 5.8 CCCC(C)COc1ccc([C@H](CN=[N+]=[N-])NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884002 148966 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 394 11 1 3 5.8 CCCC(C)COc1ccc([C@H](CN=[N+]=[N-])NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
162669690 190525 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 420 9 2 6 4.0 C[C@H](C(=O)N[C@@H](Cc1nnc(N)o1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4789484 190525 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 420 9 2 6 4.0 C[C@H](C(=O)N[C@@H](Cc1nnc(N)o1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803720 190525 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 420 9 2 6 4.0 C[C@H](C(=O)N[C@@H](Cc1nnc(N)o1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162672689 190547 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4795623 190547 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803902 190547 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162669690 190525 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 420 9 2 6 4.0 C[C@H](C(=O)N[C@@H](Cc1nnc(N)o1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4789484 190525 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 420 9 2 6 4.0 C[C@H](C(=O)N[C@@H](Cc1nnc(N)o1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803720 190525 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 420 9 2 6 4.0 C[C@H](C(=O)N[C@@H](Cc1nnc(N)o1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162672689 190547 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4795623 190547 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803902 190547 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168275346 197018 0 None 549 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5175064 197018 0 None 549 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
51355324 140773 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3716055 140773 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
134131592 149042 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 12 2 3 4.7 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884899 149042 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 12 2 3 4.7 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
134131592 149042 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 12 2 3 4.7 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884899 149042 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 12 2 3 4.7 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
51355324 140773 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3716055 140773 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](CC)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
162656011 187547 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4756228 187547 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162656011 187547 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL4756228 187547 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
162656011 187547 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4756228 187547 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162656011 187547 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL4756228 187547 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 435 11 1 5 5.4 CCCC(C)COc1ccc([C@H](Cc2nnc(C)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
51348956 124478 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3401459 124478 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 10.1016/j.bmcl.2015.02.038
118730006 124778 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 398 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)N(CC)Cc2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403778 124778 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 398 11 2 3 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)N(CC)Cc2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118727635 124309 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccnc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400226 124309 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccnc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727636 124310 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccncc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400227 124310 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 413 8 1 3 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccncc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727646 124321 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 433 8 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1csc(C)n1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400237 124321 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 433 8 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1csc(C)n1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727652 124327 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccs2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400243 124327 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccs2)cc1 10.1016/j.bmcl.2015.02.038
51356139 140535 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715186 140535 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51356139 140535 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715186 140535 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 13 3 4 4.8 CCCC(C)COc1ccc([C@H](CNC[C@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
155516532 183019 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 441 9 1 3 5.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)C(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4443664 183019 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 441 9 1 3 5.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)C(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4594745 183019 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 441 9 1 3 5.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)C(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155516532 183019 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 441 9 1 3 5.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)C(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4443664 183019 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 441 9 1 3 5.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)C(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4594745 183019 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 441 9 1 3 5.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)C(C)C)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
118730008 124785 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 369 9 2 3 4.4 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(C)c1 10.1016/j.bmcl.2015.01.036
CHEMBL3403785 124785 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 369 9 2 3 4.4 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(C)c1 10.1016/j.bmcl.2015.01.036
118727627 124302 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 437 8 1 3 5.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(C#N)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400218 124302 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 437 8 1 3 5.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(C#N)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727665 124340 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2F)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400256 124340 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2F)cc1 10.1016/j.bmcl.2015.02.038
168275843 197136 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.2 CC(=O)OCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5177010 197136 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.2 CC(=O)OCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168288763 198212 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.3 CCOC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5192946 198212 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.3 CCOC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168275843 197136 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.2 CC(=O)OCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5177010 197136 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.2 CC(=O)OCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168288763 198212 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.3 CCOC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5192946 198212 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 476 11 1 7 4.3 CCOC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
118730003 124774 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 341 9 2 3 4.0 CCCC(C)COc1ccc([C@H](CO)NC(=O)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403774 124774 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 341 9 2 3 4.0 CCCC(C)COc1ccc([C@H](CO)NC(=O)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118730011 124788 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 383 9 2 3 4.7 CC[C@H](C)COc1cc(C)c([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(C)c1 10.1016/j.bmcl.2015.01.036
CHEMBL3403788 124788 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 383 9 2 3 4.7 CC[C@H](C)COc1cc(C)c([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(C)c1 10.1016/j.bmcl.2015.01.036
118727679 124354 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 496 9 1 3 6.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400270 124354 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 496 9 1 3 6.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1 10.1016/j.bmcl.2015.02.038
67438968 124770 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL3403767 124770 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
67438968 124770 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL3403767 124770 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168291461 198648 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1cncn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5199510 198648 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1cncn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168291461 198648 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1cncn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5199510 198648 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1cncn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
162667116 189254 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 11 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4786591 189254 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 11 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C)cc1 10.1021/acs.jmedchem.0c01581
168274529 197041 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 480 10 1 5 5.8 C[C@H](C(=O)N[C@@H](Cn1cc(-c2ccccc2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5175440 197041 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 480 10 1 5 5.8 C[C@H](C(=O)N[C@@H](Cn1cc(-c2ccccc2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168281814 197761 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 11 1 5 5.1 CCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5186221 197761 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 11 1 5 5.1 CCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
162667116 189254 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 11 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4786591 189254 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 11 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C)cc1 10.1021/acs.jmedchem.0c01581
168274529 197041 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 480 10 1 5 5.8 C[C@H](C(=O)N[C@@H](Cn1cc(-c2ccccc2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5175440 197041 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 480 10 1 5 5.8 C[C@H](C(=O)N[C@@H](Cn1cc(-c2ccccc2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168281814 197761 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 11 1 5 5.1 CCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5186221 197761 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 11 1 5 5.1 CCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
67438968 124770 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 355 9 2 3 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403767 124770 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 355 9 2 3 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118730010 124787 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 385 10 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(OC)c1 10.1016/j.bmcl.2015.01.036
CHEMBL3403787 124787 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 385 10 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(OC)c1 10.1016/j.bmcl.2015.01.036
118727638 124312 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 8 1 4 4.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cncnc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400229 124312 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 414 8 1 4 4.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cncnc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
51356430 124771 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3403768 124771 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
51356430 124771 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL3403768 124771 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
51356430 124771 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3403768 124771 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
51356430 124771 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL3403768 124771 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168281296 197583 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 11 2 6 3.8 CNCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5183784 197583 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 11 2 6 3.8 CNCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168281296 197583 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 11 2 6 3.8 CNCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5183784 197583 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 11 2 6 3.8 CNCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
118727612 124289 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 440 10 1 2 6.6 CCC(CC)C(N)CCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400204 124289 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 440 10 1 2 6.6 CCC(CC)C(N)CCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118730165 124832 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 9 1 2 6.1 CN[C@@H](CC(C)C)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3404052 124832 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 9 1 2 6.1 CN[C@@H](CC(C)C)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727616 124293 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 438 9 1 2 6.3 O=C([C@@H]1C[C@H]1c1ccccc1)N(CCNCC1CCCC1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400208 124293 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 438 9 1 2 6.3 O=C([C@@H]1C[C@H]1c1ccccc1)N(CCNCC1CCCC1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727653 124328 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 402 8 1 3 5.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccoc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400244 124328 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 402 8 1 3 5.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccoc2)cc1 10.1016/j.bmcl.2015.02.038
162660471 188126 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 12 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763023 188126 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 12 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CC2)cc1 10.1021/acs.jmedchem.0c01581
162661701 188272 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4764798 188272 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCC2)cc1 10.1021/acs.jmedchem.0c01581
162660471 188126 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 12 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763023 188126 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 12 2 3 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CC2)cc1 10.1021/acs.jmedchem.0c01581
162661701 188272 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4764798 188272 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCC2)cc1 10.1021/acs.jmedchem.0c01581
118727639 124314 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 419 8 1 4 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1nccs1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400230 124314 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 419 8 1 4 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1nccs1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727655 124330 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(C2=CCCCCC2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400246 124330 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(C2=CCCCCC2)cc1 10.1016/j.bmcl.2015.02.038
118727664 124339 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccc(F)c2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400255 124339 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccc(F)c2)cc1 10.1016/j.bmcl.2015.02.038
162654782 187366 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 452 12 2 3 5.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4754332 187366 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 452 12 2 3 5.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C(C)C)cc1 10.1021/acs.jmedchem.0c01581
162654782 187366 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 452 12 2 3 5.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4754332 187366 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 452 12 2 3 5.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)C(C)C)cc1 10.1021/acs.jmedchem.0c01581
162657753 187805 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 472 12 2 3 5.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4759273 187805 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 472 12 2 3 5.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162657753 187805 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 472 12 2 3 5.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4759273 187805 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 472 12 2 3 5.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
118727618 124296 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400210 124296 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727670 124345 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400261 124345 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727647 124322 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2015.02.038
CHEMBL3400238 124322 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2015.02.038
162658043 187926 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2(C)CCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4760733 187926 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2(C)CCC2)cc1 10.1021/acs.jmedchem.0c01581
162661453 188202 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 353 8 2 3 3.8 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763920 188202 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 353 8 2 3 3.8 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162658043 187926 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2(C)CCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4760733 187926 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 450 11 2 3 5.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2(C)CCC2)cc1 10.1021/acs.jmedchem.0c01581
162661453 188202 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 353 8 2 3 3.8 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763920 188202 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 353 8 2 3 3.8 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162659288 188069 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 11 2 3 4.7 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4762227 188069 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 11 2 3 4.7 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CC2)cc1 10.1021/acs.jmedchem.0c01581
162659288 188069 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 11 2 3 4.7 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4762227 188069 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 11 2 3 4.7 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CC2)cc1 10.1021/acs.jmedchem.0c01581
51348522 124768 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as [35S]GTPgammaS binding after 60 mins by trilux scintillation counting analysis relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as [35S]GTPgammaS binding after 60 mins by trilux scintillation counting analysis relative to control
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403765 124768 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as [35S]GTPgammaS binding after 60 mins by trilux scintillation counting analysis relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as [35S]GTPgammaS binding after 60 mins by trilux scintillation counting analysis relative to control
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 10.1016/j.bmcl.2015.01.036
162666891 189299 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 12 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)CC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4787141 189299 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 12 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)CC)cc1 10.1021/acs.jmedchem.0c01581
162670172 189529 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 458 11 2 3 6.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)Nc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4790074 189529 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 458 11 2 3 6.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)Nc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168276612 197159 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 444 10 1 5 5.0 C[C@H](C(=O)N[C@@H](Cn1cc(C2CC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5177434 197159 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 444 10 1 5 5.0 C[C@H](C(=O)N[C@@H](Cn1cc(C2CC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
162666891 189299 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 12 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)CC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4787141 189299 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 12 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)CC)cc1 10.1021/acs.jmedchem.0c01581
162670172 189529 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 458 11 2 3 6.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)Nc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4790074 189529 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 458 11 2 3 6.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)Nc2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168276612 197159 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 444 10 1 5 5.0 C[C@H](C(=O)N[C@@H](Cn1cc(C2CC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5177434 197159 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 444 10 1 5 5.0 C[C@H](C(=O)N[C@@H](Cn1cc(C2CC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
10031 10185 9 None 2 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
134813902 10185 9 None 2 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL4595209 10185 9 None 2 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
10031 10185 9 None -2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation countingAgonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation counting
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
134813902 10185 9 None -2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation countingAgonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation counting
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
CHEMBL4595209 10185 9 None -2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation countingAgonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation counting
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
10031 10185 9 None 2 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
134813902 10185 9 None 2 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL4595209 10185 9 None 2 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
118730018 124794 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 331 5 2 2 3.8 O=C(N[C@@H](CO)c1ccc2ccccc2c1)[C@H]1C[C@@H]1c1ccccc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403797 124794 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 331 5 2 2 3.8 O=C(N[C@@H](CO)c1ccc2ccccc2c1)[C@H]1C[C@@H]1c1ccccc1 10.1016/j.bmcl.2015.01.036
162657060 187678 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4757666 187678 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162657060 187678 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4757666 187678 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 9 2 3 4.1 CCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
58466412 141087 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 380 8 2 3 4.4 CC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@H]2CCCN2)cc1 nan
CHEMBL3717100 141087 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 380 8 2 3 4.4 CC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@H]2CCCN2)cc1 nan
58466412 141087 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 380 8 2 3 4.4 CC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@H]2CCCN2)cc1 nan
CHEMBL3717100 141087 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 380 8 2 3 4.4 CC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)[C@H]2CCCN2)cc1 nan
162646899 186352 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.2 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4741911 186352 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.2 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162646899 186352 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.2 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4741911 186352 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.2 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CCCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
118730012 124789 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 370 9 2 4 3.8 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(C)n1 10.1016/j.bmcl.2015.01.036
CHEMBL3403789 124789 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 370 9 2 4 3.8 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(C)n1 10.1016/j.bmcl.2015.01.036
118727685 124360 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 484 10 1 4 6.0 CCOC(=O)c1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400276 124360 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 484 10 1 4 6.0 CCOC(=O)c1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
168289890 198179 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 5 4.7 CCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5192533 198179 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 5 4.7 CCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168289890 198179 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 5 4.7 CCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5192533 198179 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 5 4.7 CCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
134131464 149072 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 10 1 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885190 149072 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 10 1 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
134131464 149072 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 10 1 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885190 149072 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 383 10 1 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162643661 188469 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 12 2 4 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccco2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4776570 188469 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 12 2 4 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccco2)cc1 10.1021/acs.jmedchem.0c01581
162643661 188469 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 12 2 4 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccco2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4776570 188469 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 12 2 4 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccco2)cc1 10.1021/acs.jmedchem.0c01581
51354469 124779 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 397 10 2 3 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(C)(C)O)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403779 124779 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 397 10 2 3 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(C)(C)O)cc1 10.1016/j.bmcl.2015.01.036
118727681 124356 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 498 10 1 3 7.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(COC(C)(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400272 124356 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 498 10 1 3 7.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(COC(C)(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
162661800 188233 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CC(C)CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4764409 188233 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CC(C)CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162674526 190217 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 3 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4798774 190217 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 3 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCC2)cc1 10.1021/acs.jmedchem.0c01581
168279345 197899 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.3 COCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5188019 197899 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.3 COCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
162661800 188233 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CC(C)CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4764409 188233 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.5 CC(C)CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162674526 190217 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 3 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4798774 190217 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 3 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCC2)cc1 10.1021/acs.jmedchem.0c01581
168279345 197899 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.3 COCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5188019 197899 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.3 COCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
51355032 124781 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 396 11 1 3 5.0 CCCC(C)COc1ccc([C@H](CN(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403781 124781 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 396 11 1 3 5.0 CCCC(C)COc1ccc([C@H](CN(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
162654604 187394 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 396 10 2 3 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4754668 187394 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 396 10 2 3 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC)cc1 10.1021/acs.jmedchem.0c01581
162669183 189492 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 10 2 3 4.2 CCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4789594 189492 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 10 2 3 4.2 CCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162676113 190141 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 9 1 5 4.5 C[C@H](C(=O)N[C@@H](Cc1nnco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4797747 190141 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 9 1 5 4.5 C[C@H](C(=O)N[C@@H](Cc1nnco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162654604 187394 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 396 10 2 3 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL4754668 187394 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 396 10 2 3 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC)cc1 10.1021/acs.jmedchem.1c01075
162654604 187394 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 396 10 2 3 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4754668 187394 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 396 10 2 3 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC)cc1 10.1021/acs.jmedchem.0c01581
162669183 189492 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 10 2 3 4.2 CCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4789594 189492 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 355 10 2 3 4.2 CCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162676113 190141 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 9 1 5 4.5 C[C@H](C(=O)N[C@@H](Cc1nnco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4797747 190141 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 9 1 5 4.5 C[C@H](C(=O)N[C@@H](Cc1nnco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
58466521 7850 5 None 26 2 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N nan
7798 7850 5 None 26 2 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N nan
CHEMBL3401461 7850 5 None 26 2 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N nan
51348956 124478 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3401459 124478 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
51348672 124479 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 471 10 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
CHEMBL3401460 124479 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 471 10 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
58466519 141215 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 421 10 1 4 4.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(OCC2CCC2)cc1 nan
CHEMBL3717562 141215 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 421 10 1 4 4.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(OCC2CCC2)cc1 nan
51348816 141938 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3715838 141938 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3719573 141938 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
51348952 141939 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 451 8 1 3 5.6 CC#Cc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3719007 141939 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 451 8 1 3 5.6 CC#Cc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3719574 141939 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 451 8 1 3 5.6 CC#Cc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
58466522 141940 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 471 8 1 3 6.2 CCCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3718084 141940 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 471 8 1 3 6.2 CCCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719575 141940 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 471 8 1 3 6.2 CCCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466530 141941 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 487 8 1 4 6.1 CC(C)Oc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3714801 141941 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 487 8 1 4 6.1 CC(C)Oc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719576 141941 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 487 8 1 4 6.1 CC(C)Oc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466532 141942 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 8 1 4 5.4 COCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3718807 141942 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 8 1 4 5.4 COCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719577 141942 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 8 1 4 5.4 COCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466518 141943 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 469 8 1 4 5.3 CCCc1ccc(-c2ccc(N(CC3(N)CCOCC3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3716013 141943 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 469 8 1 4 5.3 CCCc1ccc(-c2ccc(N(CC3(N)CCOCC3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3719578 141943 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 469 8 1 4 5.3 CCCc1ccc(-c2ccc(N(CC3(N)CCOCC3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
127024356 141944 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ncccc3F)cc2)cc1 nan
CHEMBL3718515 141944 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ncccc3F)cc2)cc1 nan
CHEMBL3719579 141944 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ncccc3F)cc2)cc1 nan
67114108 141945 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 456 10 1 4 5.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3715829 141945 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 456 10 1 4 5.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3719580 141945 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 456 10 1 4 5.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
58466524 141946 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3715807 141946 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719581 141946 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466514 141948 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3717656 141948 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3719583 141948 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(COC)cc2)cc1 nan
58466535 141949 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 439 10 1 4 4.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(OCC2CCC2)cc1 nan
CHEMBL3716470 141949 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 439 10 1 4 4.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(OCC2CCC2)cc1 nan
CHEMBL3719584 141949 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 439 10 1 4 4.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(OCC2CCC2)cc1 nan
58466528 141950 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 458 10 1 5 4.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3718875 141950 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 458 10 1 5 4.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3719585 141950 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 458 10 1 5 4.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
86658431 141951 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 421 8 1 3 4.9 CCCC#Cc1ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]2C[C@@H]2c2cccc(F)n2)cc1 nan
CHEMBL3718945 141951 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 421 8 1 3 4.9 CCCC#Cc1ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]2C[C@@H]2c2cccc(F)n2)cc1 nan
CHEMBL3719586 141951 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 421 8 1 3 4.9 CCCC#Cc1ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]2C[C@@H]2c2cccc(F)n2)cc1 nan
51349088 141952 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 445 8 1 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc2cc(C3CC3)ccc2c1 nan
CHEMBL3718796 141952 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 445 8 1 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc2cc(C3CC3)ccc2c1 nan
CHEMBL3719587 141952 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 445 8 1 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc2cc(C3CC3)ccc2c1 nan
58466521 7850 5 None 26 2 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N nan
7798 7850 5 None 26 2 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N nan
CHEMBL3401461 7850 5 None 26 2 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N nan
51348956 124478 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3401459 124478 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 457 10 1 4 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
51348672 124479 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 471 10 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
CHEMBL3401460 124479 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 471 10 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
58466519 141215 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 421 10 1 4 4.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(OCC2CCC2)cc1 nan
CHEMBL3717562 141215 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 421 10 1 4 4.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(OCC2CCC2)cc1 nan
51348816 141938 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3715838 141938 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3719573 141938 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(-c2ccc(COC)cc2)cc1 nan
51348952 141939 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 8 1 3 5.6 CC#Cc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3719007 141939 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 8 1 3 5.6 CC#Cc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3719574 141939 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 451 8 1 3 5.6 CC#Cc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
58466522 141940 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 471 8 1 3 6.2 CCCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3718084 141940 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 471 8 1 3 6.2 CCCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719575 141940 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 471 8 1 3 6.2 CCCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466530 141941 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 487 8 1 4 6.1 CC(C)Oc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3714801 141941 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 487 8 1 4 6.1 CC(C)Oc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719576 141941 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 487 8 1 4 6.1 CC(C)Oc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466532 141942 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 8 1 4 5.4 COCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3718807 141942 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 8 1 4 5.4 COCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719577 141942 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 8 1 4 5.4 COCc1ccc(-c2ccc(N(CC3(N)CCCC3)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466518 141943 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 469 8 1 4 5.3 CCCc1ccc(-c2ccc(N(CC3(N)CCOCC3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3716013 141943 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 469 8 1 4 5.3 CCCc1ccc(-c2ccc(N(CC3(N)CCOCC3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
CHEMBL3719578 141943 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 469 8 1 4 5.3 CCCc1ccc(-c2ccc(N(CC3(N)CCOCC3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 nan
127024356 141944 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ncccc3F)cc2)cc1 nan
CHEMBL3718515 141944 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ncccc3F)cc2)cc1 nan
CHEMBL3719579 141944 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ncccc3F)cc2)cc1 nan
67114108 141945 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 456 10 1 4 5.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3715829 141945 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 456 10 1 4 5.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3719580 141945 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 456 10 1 4 5.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
58466524 141946 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3715807 141946 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
CHEMBL3719581 141946 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 473 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3cccc(F)n3)cc2)cc1 nan
58466514 141948 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3717656 141948 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(COC)cc2)cc1 nan
CHEMBL3719583 141948 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 475 10 1 4 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(COC)cc2)cc1 nan
58466535 141949 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 439 10 1 4 4.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(OCC2CCC2)cc1 nan
CHEMBL3716470 141949 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 439 10 1 4 4.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(OCC2CCC2)cc1 nan
CHEMBL3719584 141949 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 439 10 1 4 4.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc(OCC2CCC2)cc1 nan
58466528 141950 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 458 10 1 5 4.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3718875 141950 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 458 10 1 5 4.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
CHEMBL3719585 141950 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 458 10 1 5 4.6 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3cnccn3)cc2)cc1 nan
86658431 141951 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 421 8 1 3 4.9 CCCC#Cc1ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]2C[C@@H]2c2cccc(F)n2)cc1 nan
CHEMBL3718945 141951 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 421 8 1 3 4.9 CCCC#Cc1ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]2C[C@@H]2c2cccc(F)n2)cc1 nan
CHEMBL3719586 141951 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 421 8 1 3 4.9 CCCC#Cc1ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]2C[C@@H]2c2cccc(F)n2)cc1 nan
51349088 141952 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 445 8 1 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc2cc(C3CC3)ccc2c1 nan
CHEMBL3718796 141952 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 445 8 1 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc2cc(C3CC3)ccc2c1 nan
CHEMBL3719587 141952 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 445 8 1 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cn1)c1ccc2cc(C3CC3)ccc2c1 nan
118727611 124288 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 9 1 2 6.3 CC(C)C[C@H](N)CCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400203 124288 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 9 1 2 6.3 CC(C)C[C@H](N)CCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
58466521 7850 5 None 26 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2015.02.038
7798 7850 5 None 26 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2015.02.038
CHEMBL3401461 7850 5 None 26 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2015.02.038
51348672 124479 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 471 10 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3401460 124479 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 471 10 1 4 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727621 124297 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(OC)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400212 124297 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(OC)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
162665770 189121 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.1 CC1CC(COc2ccc([C@H](CO)NC(=O)[C@@H](C)c3ccccc3)cc2)C1 10.1021/acs.jmedchem.0c01581
CHEMBL4784512 189121 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.1 CC1CC(COc2ccc([C@H](CO)NC(=O)[C@@H](C)c3ccccc3)cc2)C1 10.1021/acs.jmedchem.0c01581
162665770 189121 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.1 CC1CC(COc2ccc([C@H](CO)NC(=O)[C@@H](C)c3ccccc3)cc2)C1 10.1021/acs.jmedchem.0c01581
CHEMBL4784512 189121 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 367 8 2 3 4.1 CC1CC(COc2ccc([C@H](CO)NC(=O)[C@@H](C)c3ccccc3)cc2)C1 10.1021/acs.jmedchem.0c01581
162674462 190111 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 10 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4797419 190111 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 10 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
155524122 183150 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 427 8 1 3 5.6 CCCc1ccc(-c2ccc(N(CC(C)(C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4453972 183150 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 427 8 1 3 5.6 CCCc1ccc(-c2ccc(N(CC(C)(C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4595791 183150 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 427 8 1 3 5.6 CCCc1ccc(-c2ccc(N(CC(C)(C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
162674462 190111 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 10 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4797419 190111 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 438 10 2 3 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
155524122 183150 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 427 8 1 3 5.6 CCCc1ccc(-c2ccc(N(CC(C)(C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4453972 183150 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 427 8 1 3 5.6 CCCc1ccc(-c2ccc(N(CC(C)(C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4595791 183150 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 427 8 1 3 5.6 CCCc1ccc(-c2ccc(N(CC(C)(C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
118727687 124362 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 427 8 2 3 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(N)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400278 124362 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 427 8 2 3 5.4 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(N)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727662 124337 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 COc1ccccc1-c1ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]2C[C@H]2c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400253 124337 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 COc1ccccc1-c1ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]2C[C@H]2c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
168274022 197016 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 419 9 1 5 4.8 Cc1noc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)n1 10.1021/acs.jmedchem.1c01075
CHEMBL5175026 197016 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 419 9 1 5 4.8 Cc1noc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)n1 10.1021/acs.jmedchem.1c01075
168274022 197016 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 419 9 1 5 4.8 Cc1noc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)n1 10.1021/acs.jmedchem.1c01075
CHEMBL5175026 197016 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 419 9 1 5 4.8 Cc1noc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)n1 10.1021/acs.jmedchem.1c01075
118727660 124335 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 COc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400251 124335 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 442 9 1 3 5.9 COc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
168279556 197638 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 486 10 1 5 6.2 C[C@H](C(=O)N[C@@H](Cn1cc(C2CCCCC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5184589 197638 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 486 10 1 5 6.2 C[C@H](C(=O)N[C@@H](Cn1cc(C2CCCCC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
162661550 188182 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCN2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763624 188182 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCN2)cc1 10.1021/acs.jmedchem.0c01581
162661550 188182 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCN2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763624 188182 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCN2)cc1 10.1021/acs.jmedchem.0c01581
168279556 197638 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 486 10 1 5 6.2 C[C@H](C(=O)N[C@@H](Cn1cc(C2CCCCC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5184589 197638 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 486 10 1 5 6.2 C[C@H](C(=O)N[C@@H](Cn1cc(C2CCCCC2)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
118727674 124349 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 480 8 1 2 6.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400265 124349 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 480 8 1 2 6.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C(F)(F)F)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727659 124334 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 Cc1ccccc1-c1ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]2C[C@H]2c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400250 124334 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 Cc1ccccc1-c1ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]2C[C@H]2c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
134130396 148998 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 11 2 3 4.3 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884316 148998 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 11 2 3 4.3 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
134130396 148998 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 11 2 3 4.3 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884316 148998 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 369 11 2 3 4.3 CCCC(C)COc1ccc([C@H](CO)NC(=O)CCc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
118727680 124355 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 456 10 1 3 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(COC)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400271 124355 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 456 10 1 3 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(COC)cc2)cc1 10.1016/j.bmcl.2015.02.038
168282137 197589 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 2 4 4.2 C[C@H](C(=O)N[C@@H](Cc1c[nH]nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5183838 197589 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 2 4 4.2 C[C@H](C(=O)N[C@@H](Cc1c[nH]nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168282137 197589 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 2 4 4.2 C[C@H](C(=O)N[C@@H](Cc1c[nH]nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5183838 197589 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 2 4 4.2 C[C@H](C(=O)N[C@@H](Cc1c[nH]nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
118727640 124315 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccs1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400231 124315 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccs1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727657 124332 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 Cc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400248 124332 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 8 1 2 6.2 Cc1ccc(-c2ccc(N(C[C@@H](N)CC(C)C)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727645 124320 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 447 8 1 4 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1nc(C)c(C)s1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400236 124320 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 447 8 1 4 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1nc(C)c(C)s1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
168277341 197077 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 5 5.2 CC(C)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5175963 197077 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 5 5.2 CC(C)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168277341 197077 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 5 5.2 CC(C)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5175963 197077 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 446 10 1 5 5.2 CC(C)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
162651966 186970 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 3 4 3.9 C[C@H](C(=O)N[C@@H](C(=O)NCc1ncc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4749480 186970 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 3 4 3.9 C[C@H](C(=O)N[C@@H](C(=O)NCc1ncc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162651966 186970 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 3 4 3.9 C[C@H](C(=O)N[C@@H](C(=O)NCc1ncc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4749480 186970 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 3 4 3.9 C[C@H](C(=O)N[C@@H](C(=O)NCc1ncc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
134131577 149018 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.4 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(C)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884700 149018 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.4 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(C)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162677103 190306 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 419 9 1 5 4.8 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4799883 190306 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 419 9 1 5 4.8 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
168275929 197359 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.2 C[C@H](C(=O)N[C@@H](Cc1cnn(C)n1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5180324 197359 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.2 C[C@H](C(=O)N[C@@H](Cc1cnn(C)n1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
134131577 149018 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.4 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(C)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884700 149018 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.4 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(C)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162677103 190306 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 419 9 1 5 4.8 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4799883 190306 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 419 9 1 5 4.8 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
168275929 197359 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.2 C[C@H](C(=O)N[C@@H](Cc1cnn(C)n1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5180324 197359 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.2 C[C@H](C(=O)N[C@@H](Cc1cnn(C)n1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
162658387 187815 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.6 CCCCC(C)Oc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4759345 187815 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.6 CCCCC(C)Oc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162643654 188449 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 341 9 2 3 3.8 CCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4776381 188449 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 341 9 2 3 3.8 CCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162658387 187815 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.6 CCCCC(C)Oc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4759345 187815 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 369 10 2 3 4.6 CCCCC(C)Oc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162643654 188449 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 341 9 2 3 3.8 CCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4776381 188449 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 341 9 2 3 3.8 CCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
118727669 124344 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2Cl)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400260 124344 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2Cl)cc1 10.1016/j.bmcl.2015.02.038
168287256 198588 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 475 10 1 6 3.8 C[C@H](C(=O)N[C@@H](Cn1cc(C(=O)N(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5198398 198588 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 475 10 1 6 3.8 C[C@H](C(=O)N[C@@H](Cn1cc(C(=O)N(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168287256 198588 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 475 10 1 6 3.8 C[C@H](C(=O)N[C@@H](Cn1cc(C(=O)N(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5198398 198588 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 475 10 1 6 3.8 C[C@H](C(=O)N[C@@H](Cn1cc(C(=O)N(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
134130479 149104 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2cccc(F)c2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885494 149104 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2cccc(F)c2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
51354469 124779 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 397 10 2 3 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(C)(C)O)cc1 nan
CHEMBL3403779 124779 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 397 10 2 3 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(C)(C)O)cc1 nan
51355032 124781 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 396 11 1 3 5.0 CCCC(C)COc1ccc([C@H](CN(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403781 124781 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 396 11 1 3 5.0 CCCC(C)COc1ccc([C@H](CN(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354470 124793 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 354 9 2 3 4.0 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403793 124793 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 354 9 2 3 4.0 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355031 140486 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 453 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715029 140486 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 453 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354737 140716 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 422 13 2 3 5.5 CCCC(C)COc1ccc([C@H](CNCC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715862 140716 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 422 13 2 3 5.5 CCCC(C)COc1ccc([C@H](CNCC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354739 140774 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CC(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716058 140774 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CC(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355033 140782 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716078 140782 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355030 140872 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 467 13 3 4 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)C(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716360 140872 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 467 13 3 4 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)C(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354738 141141 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717315 141141 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355028 141371 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718100 141371 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354736 141440 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 465 13 3 4 5.3 CCCC(C)COc1ccc([C@H](CNCC2(N)CCCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718302 141440 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 465 13 3 4 5.3 CCCC(C)COc1ccc([C@H](CNCC2(N)CCCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355029 141496 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718503 141496 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354469 124779 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 397 10 2 3 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(C)(C)O)cc1 nan
CHEMBL3403779 124779 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 397 10 2 3 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(C)(C)O)cc1 nan
51355032 124781 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 396 11 1 3 5.0 CCCC(C)COc1ccc([C@H](CN(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403781 124781 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 396 11 1 3 5.0 CCCC(C)COc1ccc([C@H](CN(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354470 124793 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 354 9 2 3 4.0 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403793 124793 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 354 9 2 3 4.0 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355031 140486 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 453 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715029 140486 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 453 13 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354737 140716 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 422 13 2 3 5.5 CCCC(C)COc1ccc([C@H](CNCC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715862 140716 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 422 13 2 3 5.5 CCCC(C)COc1ccc([C@H](CNCC2CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354739 140774 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CC(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716058 140774 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)CC(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355033 140782 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716078 140782 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 467 14 3 4 4.7 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)CCC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355030 140872 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 467 13 3 4 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)C(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3716360 140872 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 467 13 3 4 4.6 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)C(C)C)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354738 141141 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3717315 141141 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H](N)[C@@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355028 141371 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718100 141371 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 481 14 3 4 5.0 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](N)[C@H](C)CC)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354736 141440 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 465 13 3 4 5.3 CCCC(C)COc1ccc([C@H](CNCC2(N)CCCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718302 141440 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 465 13 3 4 5.3 CCCC(C)COc1ccc([C@H](CNCC2(N)CCCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51355029 141496 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3718503 141496 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 439 12 3 4 3.9 CCCC(C)COc1ccc([C@H](CNC(=O)[C@H](C)N)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
168293070 198881 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 10 2 6 3.5 CNC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5203114 198881 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 10 2 6 3.5 CNC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
134130479 149104 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2cccc(F)c2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885494 149104 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2cccc(F)c2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162656522 187704 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 12 2 3 5.0 CCCNC(=O)[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OCC(C)CCC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4758007 187704 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 12 2 3 5.0 CCCNC(=O)[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OCC(C)CCC)cc1 10.1021/acs.jmedchem.0c01581
155524318 183216 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 413 8 1 3 5.2 CCCc1ccc(-c2ccc(N(C[C@H](C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4454531 183216 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 413 8 1 3 5.2 CCCc1ccc(-c2ccc(N(C[C@H](C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596277 183216 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 413 8 1 3 5.2 CCCc1ccc(-c2ccc(N(C[C@H](C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
162656522 187704 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 12 2 3 5.0 CCCNC(=O)[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OCC(C)CCC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4758007 187704 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 424 12 2 3 5.0 CCCNC(=O)[C@H](NC(=O)[C@@H](C)c1ccccc1)c1ccc(OCC(C)CCC)cc1 10.1021/acs.jmedchem.0c01581
155524318 183216 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 413 8 1 3 5.2 CCCc1ccc(-c2ccc(N(C[C@H](C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4454531 183216 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 413 8 1 3 5.2 CCCc1ccc(-c2ccc(N(C[C@H](C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596277 183216 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 413 8 1 3 5.2 CCCc1ccc(-c2ccc(N(C[C@H](C)N)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
118727604 124281 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 432 7 1 2 6.2 N[C@H](CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1)c1ccccc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400196 124281 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 432 7 1 2 6.2 N[C@H](CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1)c1ccccc1 10.1016/j.bmcl.2015.02.038
118727614 124291 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 10 1 2 6.1 CCC(C)CNCCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400206 124291 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 10 1 2 6.1 CCC(C)CNCCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
168293070 198881 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 10 2 6 3.5 CNC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5203114 198881 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 10 2 6 3.5 CNC(=O)c1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168294517 199009 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.5 CCOc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5205098 199009 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.5 CCOc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168294517 199009 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.5 CCOc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5205098 199009 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 448 11 1 6 4.5 CCOc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
118730013 124790 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 299 6 2 3 2.6 COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403790 124790 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 299 6 2 3 2.6 COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
58466401 124780 0 None 5 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL3403780 124780 0 None 5 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL3884102 124780 0 None 5 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
58466401 124780 0 None 5 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3403780 124780 0 None 5 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884102 124780 0 None 5 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
58466401 124780 0 None 5 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3403780 124780 0 None 5 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884102 124780 0 None 5 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
162661210 188255 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 426 12 3 4 3.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCO)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4764623 188255 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 426 12 3 4 3.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCO)cc1 10.1021/acs.jmedchem.0c01581
162661210 188255 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 426 12 3 4 3.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCO)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4764623 188255 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 426 12 3 4 3.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCO)cc1 10.1021/acs.jmedchem.0c01581
118727617 124294 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(Cl)cc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400209 124294 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(Cl)cc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727671 124346 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 440 9 1 2 6.4 CCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400262 124346 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 440 9 1 2 6.4 CCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
10031 10185 9 None 2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.1c01075
134813902 10185 9 None 2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.1c01075
CHEMBL4595209 10185 9 None 2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.1c01075
10031 10185 9 None 2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.1c01075
134813902 10185 9 None 2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.1c01075
CHEMBL4595209 10185 9 None 2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.1c01075
118727641 124316 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccsc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400232 124316 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 418 8 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccsc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727667 124342 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 437 8 1 3 5.7 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccc(C#N)c2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400258 124342 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 437 8 1 3 5.7 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2cccc(C#N)c2)cc1 10.1016/j.bmcl.2015.02.038
162645574 186484 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 445 10 3 3 4.5 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4743847 186484 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 445 10 3 3 4.5 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
168271605 197024 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 9 1 5 4.7 Cc1nnn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)c1C 10.1021/acs.jmedchem.1c01075
CHEMBL5175154 197024 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 9 1 5 4.7 Cc1nnn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)c1C 10.1021/acs.jmedchem.1c01075
162645574 186484 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 445 10 3 3 4.5 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4743847 186484 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 445 10 3 3 4.5 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
168271605 197024 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 9 1 5 4.7 Cc1nnn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)c1C 10.1021/acs.jmedchem.1c01075
CHEMBL5175154 197024 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 9 1 5 4.7 Cc1nnn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)c1C 10.1021/acs.jmedchem.1c01075
10031 10185 9 None 2 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
134813902 10185 9 None 2 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
CHEMBL4595209 10185 9 None 2 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
118730009 124786 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 373 9 2 3 4.2 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.036
CHEMBL3403786 124786 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 373 9 2 3 4.2 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.036
118727690 124365 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 469 10 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CN(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400281 124365 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 469 10 1 3 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CN(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
162671884 189624 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 466 12 2 4 4.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCO2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4791411 189624 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 466 12 2 4 4.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCO2)cc1 10.1021/acs.jmedchem.0c01581
162676440 190261 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 454 12 2 5 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC(=O)OC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4799403 190261 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 454 12 2 5 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC(=O)OC)cc1 10.1021/acs.jmedchem.0c01581
162665250 188917 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 371 11 2 4 3.4 COCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4782249 188917 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 371 11 2 4 3.4 COCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162665250 188917 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 371 11 2 4 3.4 COCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4782249 188917 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 371 11 2 4 3.4 COCCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162671884 189624 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 466 12 2 4 4.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCO2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4791411 189624 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 466 12 2 4 4.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC2CCCO2)cc1 10.1021/acs.jmedchem.0c01581
162676440 190261 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 454 12 2 5 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC(=O)OC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4799403 190261 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 454 12 2 5 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCC(=O)OC)cc1 10.1021/acs.jmedchem.0c01581
10031 10185 9 None 2 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
134813902 10185 9 None 2 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
CHEMBL4595209 10185 9 None 2 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.0c01581
162660648 188058 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 391 8 1 5 4.3 C[C@H](C(=O)N[C@H](c1ccc(OCC2CCC2)cc1)c1nnco1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4762163 188058 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 391 8 1 5 4.3 C[C@H](C(=O)N[C@H](c1ccc(OCC2CCC2)cc1)c1nnco1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162660648 188058 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 391 8 1 5 4.3 C[C@H](C(=O)N[C@H](c1ccc(OCC2CCC2)cc1)c1nnco1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4762163 188058 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 391 8 1 5 4.3 C[C@H](C(=O)N[C@H](c1ccc(OCC2CCC2)cc1)c1nnco1)c1ccccc1 10.1021/acs.jmedchem.0c01581
168274798 196870 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 450 12 2 6 4.2 CCC[C@H](C)COc1ccc([C@H](Cn2cc(CO)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5172809 196870 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 450 12 2 6 4.2 CCC[C@H](C)COc1ccc([C@H](Cn2cc(CO)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
69925894 124775 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 355 10 2 3 3.9 CCCC(C)COc1ccc([C@H](CO)NC(=O)Cc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3403775 124775 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 355 10 2 3 3.9 CCCC(C)COc1ccc([C@H](CO)NC(=O)Cc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
69925894 124775 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 355 10 2 3 3.9 CCCC(C)COc1ccc([C@H](CO)NC(=O)Cc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3403775 124775 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 355 10 2 3 3.9 CCCC(C)COc1ccc([C@H](CO)NC(=O)Cc2ccccc2)cc1 10.1016/j.bmc.2016.11.058
162654926 187356 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 6 3.8 Cc1nnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4754124 187356 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 6 3.8 Cc1nnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
162654926 187356 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 6 3.8 Cc1nnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4754124 187356 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 6 3.8 Cc1nnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
118727613 124290 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 10 1 2 6.1 CC(C)CCNCCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400205 124290 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 426 10 1 2 6.1 CC(C)CCNCCN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118730166 124833 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 454 9 1 2 6.0 CC[C@H](C)[C@@H](CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1)NC(C)=O 10.1016/j.bmcl.2015.02.038
CHEMBL3404053 124833 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 454 9 1 2 6.0 CC[C@H](C)[C@@H](CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1)NC(C)=O 10.1016/j.bmcl.2015.02.038
58466521 7850 5 None 26 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human PPLS-HA-tagged-GPR88 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET based LANCE assayAgonist activity at human PPLS-HA-tagged-GPR88 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET based LANCE assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmc.2016.11.058
7798 7850 5 None 26 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human PPLS-HA-tagged-GPR88 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET based LANCE assayAgonist activity at human PPLS-HA-tagged-GPR88 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET based LANCE assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmc.2016.11.058
CHEMBL3401461 7850 5 None 26 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human PPLS-HA-tagged-GPR88 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET based LANCE assayAgonist activity at human PPLS-HA-tagged-GPR88 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET based LANCE assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmc.2016.11.058
118729997 124769 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 341 8 2 3 3.7 CC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403766 124769 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 341 8 2 3 3.7 CC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
168269611 196792 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 2 4 4.5 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)[nH]1 10.1021/acs.jmedchem.1c01075
CHEMBL5171511 196792 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 2 4 4.5 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)[nH]1 10.1021/acs.jmedchem.1c01075
155530523 183098 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 399 8 1 3 4.8 CCCc1ccc(-c2ccc(N(CCN)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4464331 183098 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 399 8 1 3 4.8 CCCc1ccc(-c2ccc(N(CCN)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4595321 183098 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 399 8 1 3 4.8 CCCc1ccc(-c2ccc(N(CCN)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155538984 183283 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 489 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)Cc3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4513479 183283 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 489 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)Cc3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596842 183283 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 489 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)Cc3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
168269611 196792 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 2 4 4.5 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)[nH]1 10.1021/acs.jmedchem.1c01075
CHEMBL5171511 196792 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 2 4 4.5 Cc1nnc(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)[nH]1 10.1021/acs.jmedchem.1c01075
155530523 183098 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 399 8 1 3 4.8 CCCc1ccc(-c2ccc(N(CCN)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4464331 183098 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 399 8 1 3 4.8 CCCc1ccc(-c2ccc(N(CCN)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4595321 183098 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 399 8 1 3 4.8 CCCc1ccc(-c2ccc(N(CCN)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155538984 183283 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 489 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)Cc3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4513479 183283 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 489 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)Cc3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596842 183283 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 489 10 1 3 6.4 CCCc1ccc(-c2ccc(N(C[C@@H](N)Cc3ccccc3)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
162652578 187233 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 539 13 2 5 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4752733 187233 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 539 13 2 5 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
162644183 188578 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 3 5 3.3 C[C@H](C(=O)N[C@@H](C(=O)NCc1nnc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4778038 188578 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 3 5 3.3 C[C@H](C(=O)N[C@@H](C(=O)NCc1nnc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162644183 188578 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 3 5 3.3 C[C@H](C(=O)N[C@@H](C(=O)NCc1nnc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4778038 188578 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 3 5 3.3 C[C@H](C(=O)N[C@@H](C(=O)NCc1nnc[nH]1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162652578 187233 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 539 13 2 5 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4752733 187233 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 539 13 2 5 5.4 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
162664171 188947 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 10 1 5 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnc(C)o2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4782571 188947 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 10 1 5 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnc(C)o2)cc1 10.1021/acs.jmedchem.0c01581
162664171 188947 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 10 1 5 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnc(C)o2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4782571 188947 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 421 10 1 5 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnc(C)o2)cc1 10.1021/acs.jmedchem.0c01581
162664171 188947 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 421 10 1 5 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnc(C)o2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL4782571 188947 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 421 10 1 5 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnc(C)o2)cc1 10.1021/acs.jmedchem.1c01075
10031 10185 9 None -2 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation countingAgonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
134813902 10185 9 None -2 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation countingAgonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL4595209 10185 9 None -2 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation countingAgonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1021/acs.jmedchem.8b00566
162663886 188784 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 440 13 2 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCOC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4780568 188784 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 440 13 2 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCOC)cc1 10.1021/acs.jmedchem.0c01581
162668147 189329 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 407 10 1 5 4.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnco2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4787512 189329 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 407 10 1 5 4.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnco2)cc1 10.1021/acs.jmedchem.0c01581
162663886 188784 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 440 13 2 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCOC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4780568 188784 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 440 13 2 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCOC)cc1 10.1021/acs.jmedchem.0c01581
162668147 189329 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 407 10 1 5 4.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnco2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4787512 189329 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 407 10 1 5 4.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)c2nnco2)cc1 10.1021/acs.jmedchem.0c01581
134130337 148904 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3883403 148904 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
134130337 148904 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3883403 148904 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 397 10 1 4 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
58466401 124780 0 None 5 2 Human 7.3 pEC50 = 7.3 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403780 124780 0 None 5 2 Human 7.3 pEC50 = 7.3 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3884102 124780 0 None 5 2 Human 7.3 pEC50 = 7.3 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
58466401 124780 0 None 5 2 Human 7.3 pEC50 = 7.3 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3403780 124780 0 None 5 2 Human 7.3 pEC50 = 7.3 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3884102 124780 0 None 5 2 Human 7.3 pEC50 = 7.3 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
162651096 187012 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 2 4 4.7 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4750015 187012 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 2 4 4.7 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162653235 187228 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 8 1 5 4.6 Cc1nnc([C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4752677 187228 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 8 1 5 4.6 Cc1nnc([C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
162644207 188592 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 439 13 3 4 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4778149 188592 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 439 13 3 4 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC)cc1 10.1021/acs.jmedchem.0c01581
162660875 188663 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 453 13 2 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4779002 188663 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 453 13 2 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C)cc1 10.1021/acs.jmedchem.0c01581
162644207 188592 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 439 13 3 4 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4778149 188592 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 439 13 3 4 3.8 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC)cc1 10.1021/acs.jmedchem.0c01581
162660875 188663 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 453 13 2 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4779002 188663 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 453 13 2 4 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN(C)C)cc1 10.1021/acs.jmedchem.0c01581
162651096 187012 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 2 4 4.7 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4750015 187012 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 446 10 2 4 4.7 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccco1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162653235 187228 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 8 1 5 4.6 Cc1nnc([C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4752677 187228 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 405 8 1 5 4.6 Cc1nnc([C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
118727689 124364 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 469 9 2 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(NC(C)=O)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400280 124364 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 469 9 2 3 5.8 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(NC(C)=O)cc2)cc1 10.1016/j.bmcl.2015.02.038
58466521 7850 5 None 26 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
7798 7850 5 None 26 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
CHEMBL3401461 7850 5 None 26 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.8b00566
118727623 124299 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400214 124299 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
162651638 186956 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 327 8 2 3 3.4 CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4749174 186956 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 327 8 2 3 3.4 CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162662433 188753 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 464 11 2 3 5.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4780227 188753 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 464 11 2 3 5.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCCC2)cc1 10.1021/acs.jmedchem.0c01581
162651638 186956 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 327 8 2 3 3.4 CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4749174 186956 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 327 8 2 3 3.4 CCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162662433 188753 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 464 11 2 3 5.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCCC2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4780227 188753 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 464 11 2 3 5.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NC2CCCCC2)cc1 10.1021/acs.jmedchem.0c01581
118730007 124784 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 422 11 1 3 5.6 CCCC(C)COc1ccc([C@H](CN2CCCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403784 124784 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 422 11 1 3 5.6 CCCC(C)COc1ccc([C@H](CN2CCCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
162660464 188125 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 382 10 2 3 3.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(N)=O)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763017 188125 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 382 10 2 3 3.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(N)=O)cc1 10.1021/acs.jmedchem.0c01581
162660464 188125 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 382 10 2 3 3.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(N)=O)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4763017 188125 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 382 10 2 3 3.9 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(N)=O)cc1 10.1021/acs.jmedchem.0c01581
162665470 189577 0 None 15 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4784623 189577 0 None 15 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4790638 189577 0 None 15 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
118727642 124317 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 402 8 1 3 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccoc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400233 124317 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 402 8 1 3 5.5 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccoc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
134129964 149064 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 411 11 1 4 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](CC)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885146 149064 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 411 11 1 4 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](CC)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
134130956 149024 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(F)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884736 149024 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(F)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162677099 190304 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2cccnc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4799879 190304 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2cccnc2)cc1 10.1021/acs.jmedchem.0c01581
134129964 149064 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 411 11 1 4 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](CC)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885146 149064 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 411 11 1 4 5.0 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](CC)c2ccccc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162667290 189333 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 357 10 2 4 3.1 COCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4787574 189333 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 357 10 2 4 3.1 COCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162667290 189333 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 357 10 2 4 3.1 COCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4787574 189333 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 357 10 2 4 3.1 COCCCOc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
134130956 149024 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(F)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884736 149024 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(F)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162677099 190304 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2cccnc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4799879 190304 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2cccnc2)cc1 10.1021/acs.jmedchem.0c01581
162665470 189577 0 None 15 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4784623 189577 0 None 15 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4790638 189577 0 None 15 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
162665470 189577 0 None 15 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL4784623 189577 0 None 15 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL4790638 189577 0 None 15 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
118727615 124292 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 452 9 1 2 6.7 O=C([C@@H]1C[C@H]1c1ccccc1)N(CCNCC1CCCCC1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400207 124292 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 452 9 1 2 6.7 O=C([C@@H]1C[C@H]1c1ccccc1)N(CCNCC1CCCCC1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
168283746 197605 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 420 11 1 5 4.8 CCCC(C)COc1ccc([C@H](Cn2ccnn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5184001 197605 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 420 11 1 5 4.8 CCCC(C)COc1ccc([C@H](Cn2ccnn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
168283746 197605 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 420 11 1 5 4.8 CCCC(C)COc1ccc([C@H](Cn2ccnn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5184001 197605 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 420 11 1 5 4.8 CCCC(C)COc1ccc([C@H](Cn2ccnn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
118727622 124298 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400213 124298 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)cc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118729996 124767 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 331 5 2 2 3.8 O=C(NC(CO)c1ccc2ccccc2c1)[C@@H]1C[C@H]1c1ccccc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403764 124767 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 331 5 2 2 3.8 O=C(NC(CO)c1ccc2ccccc2c1)[C@@H]1C[C@H]1c1ccccc1 10.1016/j.bmcl.2015.01.036
168292918 198878 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 460 9 1 5 5.4 C[C@H](C(=O)N[C@@H](Cn1cc(C(C)(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5203098 198878 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 460 9 1 5 5.4 C[C@H](C(=O)N[C@@H](Cn1cc(C(C)(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168292918 198878 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 460 9 1 5 5.4 C[C@H](C(=O)N[C@@H](Cn1cc(C(C)(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5203098 198878 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 460 9 1 5 5.4 C[C@H](C(=O)N[C@@H](Cn1cc(C(C)(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
118727672 124347 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 454 10 1 2 6.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400263 124347 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 454 10 1 2 6.8 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
134130466 149095 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL3885410 149095 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1021/acs.jmedchem.0c01581
134130466 149095 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885410 149095 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1016/j.bmc.2016.11.058
134130466 149095 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL3885410 149095 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1021/acs.jmedchem.0c01581
162646652 186261 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccn2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4740926 186261 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccn2)cc1 10.1021/acs.jmedchem.0c01581
134130466 149095 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885410 149095 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 410 10 1 3 4.6 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)N(C)C)cc1 10.1016/j.bmc.2016.11.058
162646652 186261 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccn2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4740926 186261 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccccn2)cc1 10.1021/acs.jmedchem.0c01581
51348522 124768 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
CHEMBL3403765 124768 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
67430825 140430 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 455 10 1 5 4.4 CC[C@H](C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3714859 140430 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 455 10 1 5 4.4 CC[C@H](C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
58459797 140471 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 411 11 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2ccccc2)c(OC)c1 nan
CHEMBL3714993 140471 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 411 11 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2ccccc2)c(OC)c1 nan
51348523 140526 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 372 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3715159 140526 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 372 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
51348668 140576 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 407 7 2 4 4.7 COc1cc(-c2ccc(C)cc2)ccc1[C@H](CO)NC(=O)[C@H]1C[C@@H]1c1cccs1 nan
CHEMBL3715370 140576 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 407 7 2 4 4.7 COc1cc(-c2ccc(C)cc2)ccc1[C@H](CO)NC(=O)[C@H]1C[C@@H]1c1cccs1 nan
51348520 140719 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 401 10 2 4 4.8 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3715868 140719 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 401 10 2 4 4.8 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
51348524 140827 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 387 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3716229 140827 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 387 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
51348521 140868 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 387 10 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3716350 140868 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 387 10 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
51348525 141004 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 469 11 1 5 4.8 CCCC(C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3716842 141004 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 469 11 1 5 4.8 CCCC(C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
58459803 141272 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 386 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3717751 141272 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 386 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
51348365 141306 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 391 7 2 3 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
CHEMBL3717862 141306 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 391 7 2 3 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
51348223 141470 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 421 8 2 4 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)c(OC)c2)cc1 nan
CHEMBL3718412 141470 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 421 8 2 4 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)c(OC)c2)cc1 nan
51348667 141592 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 401 10 2 4 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3718798 141592 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 401 10 2 4 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
58459793 141608 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 383 7 2 4 3.9 CCCC#Cc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(OC)c1 nan
CHEMBL3718836 141608 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 383 7 2 4 3.9 CCCC#Cc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(OC)c1 nan
58459808 141697 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 385 7 1 2 5.7 CC[C@H](NC(=O)[C@H]1C[C@@H]1c1ccccc1)c1ccc(-c2ccc(OC)cc2)cc1 nan
CHEMBL3719161 141697 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 385 7 1 2 5.7 CC[C@H](NC(=O)[C@H]1C[C@@H]1c1ccccc1)c1ccc(-c2ccc(OC)cc2)cc1 nan
51348522 124768 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
CHEMBL3403765 124768 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
67430825 140430 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 455 10 1 5 4.4 CC[C@H](C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3714859 140430 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 455 10 1 5 4.4 CC[C@H](C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
58459797 140471 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 411 11 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2ccccc2)c(OC)c1 nan
CHEMBL3714993 140471 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 411 11 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2ccccc2)c(OC)c1 nan
51348523 140526 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 372 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3715159 140526 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 372 9 2 4 4.1 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
51348668 140576 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 407 7 2 4 4.7 COc1cc(-c2ccc(C)cc2)ccc1[C@H](CO)NC(=O)[C@H]1C[C@@H]1c1cccs1 nan
CHEMBL3715370 140576 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 407 7 2 4 4.7 COc1cc(-c2ccc(C)cc2)ccc1[C@H](CO)NC(=O)[C@H]1C[C@@H]1c1cccs1 nan
51348520 140719 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 401 10 2 4 4.8 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3715868 140719 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 401 10 2 4 4.8 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
51348524 140827 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 387 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3716229 140827 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 387 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
51348521 140868 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 387 10 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3716350 140868 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 387 10 2 4 4.5 CCC(CC)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
51348525 141004 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 469 11 1 5 4.8 CCCC(C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3716842 141004 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 469 11 1 5 4.8 CCCC(C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
58459803 141272 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 386 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3717751 141272 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 386 9 2 4 4.4 CC[C@H](C)COc1ccc([C@H](CN)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
51348365 141306 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 391 7 2 3 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
CHEMBL3717862 141306 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 391 7 2 3 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 nan
51348223 141470 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 421 8 2 4 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)c(OC)c2)cc1 nan
CHEMBL3718412 141470 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 421 8 2 4 4.9 CCc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)c(OC)c2)cc1 nan
51348667 141592 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 401 10 2 4 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
CHEMBL3718798 141592 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 401 10 2 4 4.8 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(C)c1 nan
58459793 141608 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 383 7 2 4 3.9 CCCC#Cc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(OC)c1 nan
CHEMBL3718836 141608 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 383 7 2 4 3.9 CCCC#Cc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)c(OC)c1 nan
58459808 141697 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 385 7 1 2 5.7 CC[C@H](NC(=O)[C@H]1C[C@@H]1c1ccccc1)c1ccc(-c2ccc(OC)cc2)cc1 nan
CHEMBL3719161 141697 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 385 7 1 2 5.7 CC[C@H](NC(=O)[C@H]1C[C@@H]1c1ccccc1)c1ccc(-c2ccc(OC)cc2)cc1 nan
118727648 124323 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400239 124323 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2015.02.038
155561860 183273 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 457 10 1 4 5.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4583504 183273 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 457 10 1 4 5.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596729 183273 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 457 10 1 4 5.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
155561860 183273 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 457 10 1 4 5.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4583504 183273 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 457 10 1 4 5.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4596729 183273 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 457 10 1 4 5.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]3C[C@H]3c3ccccn3)cc2)cc1 10.1021/acs.jmedchem.8b00566
162652475 187231 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 339 8 2 3 3.4 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4752713 187231 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 339 8 2 3 3.4 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162652475 187231 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 339 8 2 3 3.4 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4752713 187231 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 339 8 2 3 3.4 C[C@H](C(=O)N[C@@H](CO)c1ccc(OCC2CC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
118727668 124343 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400259 124343 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 446 8 1 2 6.5 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727691 124366 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 455 10 2 3 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CNC)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400282 124366 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 455 10 2 3 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CNC)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727624 124300 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400215 124300 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
168275346 197018 0 None -549 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at wild type GPR88 expressed in C57BL/6J mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at wild type GPR88 expressed in C57BL/6J mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5175064 197018 0 None -549 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at wild type GPR88 expressed in C57BL/6J mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at wild type GPR88 expressed in C57BL/6J mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
118727683 124358 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 484 10 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CC(=O)OC)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400274 124358 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 484 10 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(CC(=O)OC)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727666 124341 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 437 8 1 3 5.7 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C#N)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400257 124341 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 437 8 1 3 5.7 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C#N)cc2)cc1 10.1016/j.bmcl.2015.02.038
162663827 188734 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 461 10 2 5 4.4 Cc1cnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4779964 188734 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 461 10 2 5 4.4 Cc1cnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
162663827 188734 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 461 10 2 5 4.4 Cc1cnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
CHEMBL4779964 188734 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 461 10 2 5 4.4 Cc1cnc(CNC(=O)[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)o1 10.1021/acs.jmedchem.0c01581
118730014 124791 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 359 8 2 4 3.7 CC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403791 124791 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 359 8 2 4 3.7 CC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 10.1016/j.bmcl.2015.01.036
162653251 190443 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4751633 190443 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4802826 190443 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168281316 197598 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 11 1 6 4.2 C[C@H](C(=O)N[C@@H](Cn1cc(CN(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5183956 197598 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 11 1 6 4.2 C[C@H](C(=O)N[C@@H](Cn1cc(CN(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168281316 197598 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 11 1 6 4.2 C[C@H](C(=O)N[C@@H](Cn1cc(CN(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5183956 197598 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 461 11 1 6 4.2 C[C@H](C(=O)N[C@@H](Cn1cc(CN(C)C)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
162653251 190443 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4751633 190443 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4802826 190443 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 422 10 2 6 4.3 CC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
118727675 124350 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 470 10 1 3 6.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400266 124350 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 470 10 1 3 6.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
58466521 7850 5 None 26 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.0c01581
7798 7850 5 None 26 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.0c01581
CHEMBL3401461 7850 5 None 26 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.0c01581
118727631 124305 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)c(F)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400222 124305 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccc(F)c(F)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
162669578 189497 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 4 5.2 C[C@H](C(=O)N[C@@H](C(=O)NCc1cccs1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4789643 189497 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 4 5.2 C[C@H](C(=O)N[C@@H](C(=O)NCc1cccs1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162669578 189497 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 4 5.2 C[C@H](C(=O)N[C@@H](C(=O)NCc1cccs1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4789643 189497 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 462 10 2 4 5.2 C[C@H](C(=O)N[C@@H](C(=O)NCc1cccs1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
58466521 7850 5 None 26 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.0c01581
7798 7850 5 None 26 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.0c01581
CHEMBL3401461 7850 5 None 26 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.0c01581
58466521 7850 5 None 26 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR88 expressed in HEK293T cells assessed as reduction in cAMP production incubated for 15 mins measured after 1 hr by by FLIPR assayAgonist activity at human GPR88 expressed in HEK293T cells assessed as reduction in cAMP production incubated for 15 mins measured after 1 hr by by FLIPR assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.1c01075
7798 7850 5 None 26 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR88 expressed in HEK293T cells assessed as reduction in cAMP production incubated for 15 mins measured after 1 hr by by FLIPR assayAgonist activity at human GPR88 expressed in HEK293T cells assessed as reduction in cAMP production incubated for 15 mins measured after 1 hr by by FLIPR assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.1c01075
CHEMBL3401461 7850 5 None 26 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human GPR88 expressed in HEK293T cells assessed as reduction in cAMP production incubated for 15 mins measured after 1 hr by by FLIPR assayAgonist activity at human GPR88 expressed in HEK293T cells assessed as reduction in cAMP production incubated for 15 mins measured after 1 hr by by FLIPR assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1021/acs.jmedchem.1c01075
118730002 124773 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 381 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403773 124773 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 381 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118727643 124318 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 433 8 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1nc(C)cs1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400234 124318 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 433 8 1 4 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1nc(C)cs1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
162658645 190468 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4760182 190468 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803101 190468 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168270814 196828 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 6 3.9 C[C@H](C(=O)N[C@@H](Cn1cc(C=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5172064 196828 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 6 3.9 C[C@H](C(=O)N[C@@H](Cn1cc(C=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
58459796 141497 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 387 10 2 4 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3718508 141497 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 387 10 2 4 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
58459796 141497 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 387 10 2 4 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
CHEMBL3718508 141497 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 387 10 2 4 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@H]2C[C@@H]2c2cccs2)cc1 nan
162658645 190468 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4760182 190468 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803101 190468 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168270814 196828 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 6 3.9 C[C@H](C(=O)N[C@@H](Cn1cc(C=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5172064 196828 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 432 10 1 6 3.9 C[C@H](C(=O)N[C@@H](Cn1cc(C=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
162652798 187245 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 2 5 4.1 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccon1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4752868 187245 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 2 5 4.1 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccon1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
162652798 187245 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 2 5 4.1 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccon1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
CHEMBL4752868 187245 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 447 10 2 5 4.1 C[C@H](C(=O)N[C@@H](C(=O)NCc1ccon1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c01581
118727673 124348 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 468 8 1 2 7.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C(C)(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400264 124348 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 468 8 1 2 7.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C(C)(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
168274798 196870 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 450 12 2 6 4.2 CCC[C@H](C)COc1ccc([C@H](Cn2cc(CO)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5172809 196870 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 450 12 2 6 4.2 CCC[C@H](C)COc1ccc([C@H](Cn2cc(CO)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
162665334 190509 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4783876 190509 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803469 190509 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
118727629 124303 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cc(F)ccc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400220 124303 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cc(F)ccc1F)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
162665334 190509 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4783876 190509 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4803469 190509 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 436 11 2 6 4.7 CCC[C@H](C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
134131406 149098 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2F)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885445 149098 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2F)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
162644557 186232 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 425 12 3 4 3.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4740613 186232 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 425 12 3 4 3.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN)cc1 10.1021/acs.jmedchem.0c01581
162644557 186232 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 425 12 3 4 3.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4740613 186232 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 425 12 3 4 3.5 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCN)cc1 10.1021/acs.jmedchem.0c01581
134131406 149098 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2F)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3885445 149098 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 401 10 1 4 4.2 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccccc2F)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
58466533 141947 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 489 10 1 4 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
CHEMBL3714828 141947 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 489 10 1 4 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
CHEMBL3719582 141947 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayActivity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 489 10 1 4 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
58466533 141947 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 489 10 1 4 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
CHEMBL3714828 141947 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 489 10 1 4 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
CHEMBL3719582 141947 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayActivity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 489 10 1 4 6.2 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cccc(F)n1)c1ccc(-c2ccc(OC(C)C)cc2)cc1 nan
118727670 124345 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400261 124345 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
51348370 141548 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@@H]3C[C@H]3c3cccs3)cc2)cc1 nan
CHEMBL3718649 141548 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Modulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assayModulator activity at GPR88 (unknown origin) expressed in cell membranes incubated for 1 hr by liquid scintillation counting based [35S]GTPgammaS binding assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@@H]3C[C@H]3c3cccs3)cc2)cc1 nan
51348370 141548 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@@H]3C[C@H]3c3cccs3)cc2)cc1 nan
CHEMBL3718649 141548 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Modulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at GPR88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@@H]3C[C@H]3c3cccs3)cc2)cc1 nan
51355598 124274 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 385 11 3 4 3.4 CCCC(C)COc1ccc([C@H](CO)NC(=O)C(CO)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3400186 124274 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 385 11 3 4 3.4 CCCC(C)COc1ccc([C@H](CO)NC(=O)C(CO)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118730005 124777 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 384 11 3 4 3.6 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](NC)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403777 124777 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 384 11 3 4 3.6 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](NC)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
162673915 189812 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccncc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4793946 189812 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccncc2)cc1 10.1021/acs.jmedchem.0c01581
162673915 189812 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccncc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4793946 189812 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 473 12 2 4 5.2 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCc2ccncc2)cc1 10.1021/acs.jmedchem.0c01581
118730161 124828 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3404048 124828 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 412 8 1 2 5.9 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
168278367 197959 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.4 Cc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5189064 197959 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.4 Cc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
51354740 140480 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715014 140480 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 1 hr by [35S]GTPgammaS binding assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
51354740 140480 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
CHEMBL3715014 140480 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Modulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assayModulator activity at G-protein-coupled receptor 88 (unknown origin) incubated for 30 mins by cell based cAMP HTRF assay
ChEMBL 465 12 3 4 4.3 CCCC(C)COc1ccc([C@H](CNC(=O)[C@@H]2CCCN2)NC(=O)[C@@H](C)c2ccccc2)cc1 nan
168278367 197959 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.4 Cc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5189064 197959 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 418 9 1 5 4.4 Cc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168275346 197018 0 None -549 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at wild type GPR88 expressed in mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at wild type GPR88 expressed in mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
CHEMBL5175064 197018 0 None -549 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at wild type GPR88 expressed in mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting methodAgonist activity at wild type GPR88 expressed in mouse striatal membrane assessed as [35S] GTPgammaS binding incubated for 1 hr by liquid scintillation counting method
ChEMBL 477 12 2 6 4.1 CCC[C@H](C)COc1ccc([C@H](Cn2cc(C(=O)NC)nn2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.1c01075
162657387 187856 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 525 13 3 5 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4759904 187856 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 525 13 3 5 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
162657387 187856 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 525 13 3 5 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4759904 187856 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production by TR-FRET assay
ChEMBL 525 13 3 5 5.1 CCCC(C)COc1ccc([C@@H](NC(=O)[C@@H](C)c2ccccc2)C(=O)NCCNC(=O)OC(C)(C)C)cc1 10.1021/acs.jmedchem.0c01581
51355880 124782 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 451 11 1 4 4.7 CCCC(C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403782 124782 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 451 11 1 4 4.7 CCCC(C)COc1ccc([C@H](CN2CCN(C)CC2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
118727676 124351 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 456 10 1 3 6.3 CCOc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400267 124351 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 456 10 1 3 6.3 CCOc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]3C[C@H]3c3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
118727663 124338 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400254 124338 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 430 8 1 2 6.0 CC(C)C[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2015.02.038
168269202 196794 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 434 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CO)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5171567 196794 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 434 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CO)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168296691 199000 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 10 2 6 3.2 C[C@H](C(=O)N[C@@H](Cn1cc(C(N)=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5204827 199000 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 10 2 6 3.2 C[C@H](C(=O)N[C@@H](Cn1cc(C(N)=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
51356141 124783 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 438 11 1 4 4.8 CCCC(C)COc1ccc([C@H](CN2CCOCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403783 124783 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 438 11 1 4 4.8 CCCC(C)COc1ccc([C@H](CN2CCOCC2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2015.01.036
168269202 196794 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 434 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CO)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5171567 196794 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 434 10 2 6 3.6 C[C@H](C(=O)N[C@@H](Cn1cc(CO)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168296691 199000 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 10 2 6 3.2 C[C@H](C(=O)N[C@@H](Cn1cc(C(N)=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5204827 199000 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 447 10 2 6 3.2 C[C@H](C(=O)N[C@@H](Cn1cc(C(N)=O)nn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168288752 198202 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 488 14 1 5 6.2 CCCCCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5192812 198202 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 488 14 1 5 6.2 CCCCCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
168288752 198202 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 488 14 1 5 6.2 CCCCCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
CHEMBL5192812 198202 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 488 14 1 5 6.2 CCCCCCc1cn(C[C@H](NC(=O)[C@@H](C)c2ccccc2)c2ccc(OCC3CCC3)cc2)nn1 10.1021/acs.jmedchem.1c01075
51348522 124768 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 10.1016/j.bmcl.2015.01.036
CHEMBL3403765 124768 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to controlAgonist activity at GPR88 (unknown origin) transfected in forskolin-stimulated HEK cells assessed as inhibition of cAMP production after 30 mins by HTRF method relative to control
ChEMBL 377 6 2 3 4.7 Cc1ccc(-c2ccc([C@H](CO)NC(=O)[C@H]3C[C@@H]3c3cccs3)cc2)cc1 10.1016/j.bmcl.2015.01.036
118727678 124353 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 504 10 1 3 7.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(Oc3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400269 124353 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 504 10 1 3 7.7 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(Oc3ccccc3)cc2)cc1 10.1016/j.bmcl.2015.02.038
162665470 189577 0 None -15 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation countingAgonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation counting
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4784623 189577 0 None -15 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation countingAgonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation counting
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
CHEMBL4790638 189577 0 None -15 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation countingAgonist activity at GPR88 in mouse striatal membrane assessed as [35S]-GTPgammaS-binding by liquid scintillation counting
ChEMBL 436 11 2 6 4.7 CCCC(C)COc1ccc([C@H](Cc2nnc(N)o2)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1021/acs.jmedchem.0c01581
168275176 197431 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1ccnn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5181466 197431 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1ccnn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
168275176 197431 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1ccnn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
CHEMBL5181466 197431 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assayAgonist activity at GPR88 (unknown origin) expressed in CHO cells coexpressing PPLS-HA assessed as reduction in forskolin-stimulated cAMP production and measured after 90 mins by Lance TR-FRET cAMP assay
ChEMBL 404 9 1 5 4.1 C[C@H](C(=O)N[C@@H](Cn1ccnn1)c1ccc(OCC2CCC2)cc1)c1ccccc1 10.1021/acs.jmedchem.1c01075
134130076 149047 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 413 11 1 5 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(OC)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884939 149047 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 413 11 1 5 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(OC)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
134130076 149047 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 413 11 1 5 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(OC)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884939 149047 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assayAgonist activity at PPLS-HA-tagged-GPR88 (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production measured after 30 mins by TR-FRET assay
ChEMBL 413 11 1 5 4.1 CCCC(C)COc1ccc([C@@H](NC(=O)Cc2ccc(OC)cc2)C(=O)OC)cc1 10.1016/j.bmc.2016.11.058
155525986 177806 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 443 9 1 4 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC)cc2)cc1 10.1021/acs.jmedchem.8b00566
CHEMBL4456708 177806 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assayAgonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay
ChEMBL 443 9 1 4 5.3 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccn1)c1ccc(-c2ccc(OC)cc2)cc1 10.1021/acs.jmedchem.8b00566
118727630 124304 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cc(F)cc(F)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400221 124304 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 448 8 1 2 6.1 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1cc(F)cc(F)c1)c1ccc(-c2ccccc2)cc1 10.1016/j.bmcl.2015.02.038
118727686 124361 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 483 9 1 3 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C(=O)N(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
CHEMBL3400277 124361 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assayAgonist activity at GPR88 (unknown origin) transfected into cells assessed as cAMP accumulation by HTRF assay
ChEMBL 483 9 1 3 5.6 CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ccccc1)c1ccc(-c2ccc(C(=O)N(C)C)cc2)cc1 10.1016/j.bmcl.2015.02.038
12395 10184 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist potency determined in a TR-FRET cAMP assay using CHO cells expressing hGPR88Agonist potency determined in a TR-FRET cAMP assay using CHO cells expressing hGPR88
Guide to Pharmacology 491 10 1 5 5.2 N[C@@H]([C@@H](C)OC)CN(C(=O)[C@H]1[C@H](c2ccc(F)cn2)C1)c1ccc(c2ccc(OC(C)C)cc2)cc1 36749855
167993640 10184 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist potency determined in a TR-FRET cAMP assay using CHO cells expressing hGPR88Agonist potency determined in a TR-FRET cAMP assay using CHO cells expressing hGPR88
Guide to Pharmacology 491 10 1 5 5.2 N[C@@H]([C@@H](C)OC)CN(C(=O)[C@H]1[C@H](c2ccc(F)cn2)C1)c1ccc(c2ccc(OC(C)C)cc2)cc1 36749855
10031 10185 9 None 2 2 Human 7.6 pEC50 = 7.6 Functional
In an <i>in vitro</i> cAMP functional assay.In an <i>in vitro</i> cAMP functional assay.
Guide to Pharmacology 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 30011199
134813902 10185 9 None 2 2 Human 7.6 pEC50 = 7.6 Functional
In an <i>in vitro</i> cAMP functional assay.In an <i>in vitro</i> cAMP functional assay.
Guide to Pharmacology 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 30011199
CHEMBL4595209 10185 9 None 2 2 Human 7.6 pEC50 = 7.6 Functional
In an <i>in vitro</i> cAMP functional assay.In an <i>in vitro</i> cAMP functional assay.
Guide to Pharmacology 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 30011199
58466521 7850 5 None 26 2 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 24793972
7798 7850 5 None 26 2 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 24793972
CHEMBL3401461 7850 5 None 26 2 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 24793972


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
CHEMBL5285428 201077 0 None - 1 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]3C[C@@H]3c3ccccn3)cc2)cc1 10.1016/j.bmcl.2022.129120
51356430 124771 0 None - 1 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
CHEMBL3403768 124771 0 None - 1 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
58466401 124780 0 None - 1 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
CHEMBL3403780 124780 0 None - 1 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
CHEMBL3884102 124780 0 None - 1 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
10031 10185 9 None -3 3 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
134813902 10185 9 None -3 3 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
CHEMBL4595209 10185 9 None -3 3 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
58466521 7850 5 None - 1 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2022.129120
7798 7850 5 None - 1 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2022.129120
CHEMBL3401461 7850 5 None - 1 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assayAgonist activity at GPR88 (unknown origin) transfected in HEK293 cells assessed as cAMP level by GloSensor cAMP assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2022.129120
58466401 124780 0 None - 1 Mouse 6.0 pEC50 = 6.0 Binding
Agonist activity at GPR88 in mouse striatal membranes assessed as increase in [35S]-GTP-gammaS bindingAgonist activity at GPR88 in mouse striatal membranes assessed as increase in [35S]-GTP-gammaS binding
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3403780 124780 0 None - 1 Mouse 6.0 pEC50 = 6.0 Binding
Agonist activity at GPR88 in mouse striatal membranes assessed as increase in [35S]-GTP-gammaS bindingAgonist activity at GPR88 in mouse striatal membranes assessed as increase in [35S]-GTP-gammaS binding
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
CHEMBL3884102 124780 0 None - 1 Mouse 6.0 pEC50 = 6.0 Binding
Agonist activity at GPR88 in mouse striatal membranes assessed as increase in [35S]-GTP-gammaS bindingAgonist activity at GPR88 in mouse striatal membranes assessed as increase in [35S]-GTP-gammaS binding
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmc.2016.11.058
10031 10185 9 None 3 3 Mouse 7.4 pKd = 7.4 Binding
Binding affinity to GPR88 in mouse striatal membrane by filtration methodBinding affinity to GPR88 in mouse striatal membrane by filtration method
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
134813902 10185 9 None 3 3 Mouse 7.4 pKd = 7.4 Binding
Binding affinity to GPR88 in mouse striatal membrane by filtration methodBinding affinity to GPR88 in mouse striatal membrane by filtration method
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
CHEMBL4595209 10185 9 None 3 3 Mouse 7.4 pKd = 7.4 Binding
Binding affinity to GPR88 in mouse striatal membrane by filtration methodBinding affinity to GPR88 in mouse striatal membrane by filtration method
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
10031 10185 9 None -3 3 Human 7.1 pKd = 7.1 Binding
Binding affinity to PPLS-HA tagged human GPR88 expressed in CHO cell membrane by filtration methodBinding affinity to PPLS-HA tagged human GPR88 expressed in CHO cell membrane by filtration method
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
134813902 10185 9 None -3 3 Human 7.1 pKd = 7.1 Binding
Binding affinity to PPLS-HA tagged human GPR88 expressed in CHO cell membrane by filtration methodBinding affinity to PPLS-HA tagged human GPR88 expressed in CHO cell membrane by filtration method
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
CHEMBL4595209 10185 9 None -3 3 Human 7.1 pKd = 7.1 Binding
Binding affinity to PPLS-HA tagged human GPR88 expressed in CHO cell membrane by filtration methodBinding affinity to PPLS-HA tagged human GPR88 expressed in CHO cell membrane by filtration method
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
58466401 124780 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
CHEMBL3403780 124780 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
CHEMBL3884102 124780 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 368 10 2 3 4.4 CCCC(C)COc1ccc([C@H](CN)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
10031 10185 9 None -3 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
134813902 10185 9 None -3 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
CHEMBL4595209 10185 9 None -3 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 459 10 1 5 4.4 COCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](OC)C)N 10.1016/j.bmcl.2022.129120
58466521 7850 5 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2022.129120
7798 7850 5 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2022.129120
CHEMBL3401461 7850 5 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(cc1)c1ccc(cc1)N(C(=O)[C@@H]1C[C@H]1c1ccccn1)C[C@H]([C@H](CC)C)N 10.1016/j.bmcl.2022.129120
CHEMBL5285428 201077 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 455 10 1 3 6.2 CCCc1ccc(-c2ccc(N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@H]3C[C@@H]3c3ccccn3)cc2)cc1 10.1016/j.bmcl.2022.129120
51356430 124771 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120
CHEMBL3403768 124771 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assayDisplacement of [3H]RTI-33 from GPR88 (unknown origin) by competition binding assay
ChEMBL 369 10 2 3 4.5 CCCC(C)COc1ccc([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)cc1 10.1016/j.bmcl.2022.129120