Ligand source activities (1 row/activity)
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 162644596 | 186198 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | ||
| CHEMBL4740228 | 186198 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | ||
| 153585580 | 186223 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| CHEMBL4740491 | 186223 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| 153585418 | 186226 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 434 | 5 | 1 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4740519 | 186226 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 434 | 5 | 1 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 148659040 | 186343 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(Br)n3c2=O)cc1 | nan | ||
| CHEMBL4741806 | 186343 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(Br)n3c2=O)cc1 | nan | ||
| 153585598 | 186394 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 446 | 5 | 1 | 7 | 1.9 | C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4742673 | 186394 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 446 | 5 | 1 | 7 | 1.9 | C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 148397968 | 186414 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | ||
| CHEMBL4742901 | 186414 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | ||
| 147048009 | 186436 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(Br)cn3c2=O)cc1 | nan | ||
| CHEMBL4743199 | 186436 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(Br)cn3c2=O)cc1 | nan | ||
| 147451915 | 186466 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4743612 | 186466 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 152956498 | 186489 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 324 | 4 | 1 | 5 | 2.2 | Cc1ccc([C@H](C)NC(=O)C(C)n2nc3ccccn3c2=O)cc1 | nan | ||
| CHEMBL4743938 | 186489 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 324 | 4 | 1 | 5 | 2.2 | Cc1ccc([C@H](C)NC(=O)C(C)n2nc3ccccn3c2=O)cc1 | nan | ||
| 153585490 | 186520 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ncccn2c1=O | nan | ||
| CHEMBL4744169 | 186520 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ncccn2c1=O | nan | ||
| 153585688 | 186537 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4744340 | 186537 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 162647825 | 186614 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | ||
| CHEMBL4745096 | 186614 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | ||
| 152005060 | 186641 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 447 | 5 | 1 | 8 | 1.3 | C[C@H](NC(=O)Cn1nc2c(N3CCN(C)CC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4745432 | 186641 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 447 | 5 | 1 | 8 | 1.3 | C[C@H](NC(=O)Cn1nc2c(N3CCN(C)CC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 150944515 | 186643 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 425 | 5 | 2 | 7 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(NC(=O)OC(C)(C)C)cccn3c2=O)cc1 | nan | ||
| CHEMBL4745487 | 186643 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 425 | 5 | 2 | 7 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(NC(=O)OC(C)(C)C)cccn3c2=O)cc1 | nan | ||
| 147626442 | 186658 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1cn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2cn1 | nan | ||
| CHEMBL4745668 | 186658 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1cn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2cn1 | nan | ||
| 150995037 | 186698 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cnccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4746108 | 186698 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cnccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162648023 | 186754 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 452 | 7 | 2 | 9 | 1.5 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4746822 | 186754 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 452 | 7 | 2 | 9 | 1.5 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585512 | 186807 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 367 | 4 | 1 | 6 | 1.7 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4747431 | 186807 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 367 | 4 | 1 | 6 | 1.7 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162650006 | 186904 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2cccnn2c1=O | nan | ||
| CHEMBL4748681 | 186904 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2cccnn2c1=O | nan | ||
| 153585452 | 186990 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL4749705 | 186990 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)cc1 | nan | ||
| 151976938 | 187019 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | ||
| CHEMBL4750143 | 187019 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | ||
| 147634500 | 187057 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F | nan | ||
| CHEMBL4750692 | 187057 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F | nan | ||
| 149094095 | 187061 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 421 | 6 | 1 | 7 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4750718 | 187061 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 421 | 6 | 1 | 7 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 152023194 | 187109 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(Cl)cccn3c2=O)cc1 | nan | ||
| CHEMBL4751203 | 187109 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(Cl)cccn3c2=O)cc1 | nan | ||
| 153585601 | 187116 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 478 | 6 | 1 | 8 | 2.0 | C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4751259 | 187116 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 478 | 6 | 1 | 8 | 2.0 | C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585718 | 187120 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4751304 | 187120 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585541 | 187160 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 341 | 5 | 1 | 7 | 1.1 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2n1 | nan | ||
| CHEMBL4751720 | 187160 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 341 | 5 | 1 | 7 | 1.1 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2n1 | nan | ||
| 153585550 | 187172 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | ||
| CHEMBL4751886 | 187172 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | ||
| 153585655 | 187255 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 493 | 7 | 1 | 8 | 2.9 | COC1CCN(c2ccn3c(=O)n(CC(=O)N[C@@H](C)c4ccc(OC(F)(F)F)cc4)nc3c2)CC1 | nan | ||
| CHEMBL4752993 | 187255 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 493 | 7 | 1 | 8 | 2.9 | COC1CCN(c2ccn3c(=O)n(CC(=O)N[C@@H](C)c4ccc(OC(F)(F)F)cc4)nc3c2)CC1 | nan | ||
| 147378727 | 187306 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 380 | 6 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)c(F)c1 | nan | ||
| CHEMBL4753547 | 187306 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 380 | 6 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)c(F)c1 | nan | ||
| 162653797 | 187309 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F | nan | ||
| CHEMBL4753587 | 187309 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F | nan | ||
| 150050373 | 187374 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 339 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(C)nc(C)n3c2=O)cc1 | nan | ||
| CHEMBL4754384 | 187374 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 339 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(C)nc(C)n3c2=O)cc1 | nan | ||
| 149101043 | 187382 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4754476 | 187382 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585478 | 187384 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4754503 | 187384 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585445 | 187536 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 382 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| CHEMBL4756137 | 187536 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 382 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| 153585588 | 187565 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 444 | 5 | 2 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CNC4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4756392 | 187565 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 444 | 5 | 2 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CNC4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585712 | 187570 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 419 | 6 | 2 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(NC3COC3)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4756431 | 187570 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 419 | 6 | 2 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(NC3COC3)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 94095050 | 187590 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 380 | 5 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4756787 | 187590 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 380 | 5 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585575 | 187608 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 433 | 5 | 2 | 8 | 1.0 | C[C@H](NC(=O)Cn1nc2c(N3CCNCC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4756937 | 187608 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 433 | 5 | 2 | 8 | 1.0 | C[C@H](NC(=O)Cn1nc2c(N3CCNCC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162656575 | 187662 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | ||
| CHEMBL4757480 | 187662 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | ||
| 153585415 | 187667 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O | nan | ||
| CHEMBL4757506 | 187667 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O | nan | ||
| 162656504 | 187675 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4757619 | 187675 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585404 | 187687 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | ||
| CHEMBL4757742 | 187687 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | ||
| 149421402 | 187735 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 452 | 7 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(OC3COC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4758375 | 187735 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 452 | 7 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(OC3COC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 162657688 | 187834 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)ccc1Cl | nan | ||
| CHEMBL4759611 | 187834 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)ccc1Cl | nan | ||
| 153585534 | 187863 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 413 | 5 | 1 | 7 | 2.1 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 | nan | ||
| CHEMBL4759991 | 187863 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 413 | 5 | 1 | 7 | 2.1 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 | nan | ||
| 162657416 | 187899 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | ||
| CHEMBL4760528 | 187899 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | ||
| 153585663 | 187934 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1Cl | nan | ||
| CHEMBL4760812 | 187934 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1Cl | nan | ||
| 153585574 | 188000 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4761321 | 188000 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162660420 | 188054 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 5 | 1 | 6 | 2.0 | CC[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4762121 | 188054 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 5 | 1 | 6 | 2.0 | CC[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 147987797 | 188063 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| CHEMBL4762206 | 188063 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| 153585643 | 188120 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 381 | 5 | 1 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4762957 | 188120 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 381 | 5 | 1 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 147323186 | 188163 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 325 | 4 | 1 | 6 | 1.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cnc(C)cn3c2=O)cc1 | nan | ||
| CHEMBL4763362 | 188163 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 325 | 4 | 1 | 6 | 1.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cnc(C)cn3c2=O)cc1 | nan | ||
| 153585610 | 188224 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O | nan | ||
| CHEMBL4764290 | 188224 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O | nan | ||
| 162661581 | 188243 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 362 | 4 | 1 | 5 | 2.7 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O | nan | ||
| CHEMBL4764506 | 188243 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 362 | 4 | 1 | 5 | 2.7 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O | nan | ||
| 153585681 | 188262 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4764666 | 188262 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 152494840 | 188276 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC(O)CC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4764839 | 188276 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC(O)CC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 134043805 | 188548 | 1 | None | 3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 362 | 6 | 1 | 6 | 2.0 | CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 | nan | ||
| CHEMBL4777673 | 188548 | 1 | None | 3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 362 | 6 | 1 | 6 | 2.0 | CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 | nan | ||
| 162665057 | 188845 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL4781404 | 188845 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| 149618414 | 189040 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 325 | 4 | 2 | 6 | 1.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(N)cccn3c2=O)cc1 | nan | ||
| CHEMBL4783739 | 189040 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 325 | 4 | 2 | 6 | 1.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(N)cccn3c2=O)cc1 | nan | ||
| 153585453 | 189047 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 431 | 6 | 1 | 7 | 2.6 | C[C@H](NC(=O)Cn1nc2c(C(F)F)nccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4783815 | 189047 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 431 | 6 | 1 | 7 | 2.6 | C[C@H](NC(=O)Cn1nc2c(C(F)F)nccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585542 | 189085 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL4784153 | 189085 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| 151570395 | 189166 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n2c1 | nan | ||
| CHEMBL4785283 | 189166 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n2c1 | nan | ||
| 153585417 | 189206 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1Cl | nan | ||
| CHEMBL4785963 | 189206 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1Cl | nan | ||
| 162667558 | 189241 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 331 | 4 | 1 | 6 | 1.4 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL4786371 | 189241 | 0 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 331 | 4 | 1 | 6 | 1.4 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)cc1 | nan | ||
| 153585609 | 189251 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 465 | 6 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4786573 | 189251 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 465 | 6 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 151394869 | 189315 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4787308 | 189315 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 151043804 | 189454 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4789123 | 189454 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162670176 | 189530 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 377 | 5 | 1 | 6 | 2.2 | CC(C)[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4790080 | 189530 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 377 | 5 | 1 | 6 | 2.2 | CC(C)[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 150234341 | 189569 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | nan | ||
| CHEMBL4790498 | 189569 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | nan | ||
| 149881970 | 189633 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2n1 | nan | ||
| CHEMBL4791551 | 189633 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2n1 | nan | ||
| 149784975 | 189657 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccncn3c2=O)cc1 | nan | ||
| CHEMBL4791843 | 189657 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccncn3c2=O)cc1 | nan | ||
| 162670473 | 189689 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 | nan | ||
| CHEMBL4792356 | 189689 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 | nan | ||
| 153585679 | 189702 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F | nan | ||
| CHEMBL4792515 | 189702 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F | nan | ||
| 162671011 | 189723 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 | nan | ||
| CHEMBL4792732 | 189723 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 | nan | ||
| 153585435 | 189773 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 359 | 4 | 1 | 6 | 2.0 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 | nan | ||
| CHEMBL4793463 | 189773 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 359 | 4 | 1 | 6 | 2.0 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 | nan | ||
| 153585524 | 189909 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(F)cccn3c2=O)cc1 | nan | ||
| CHEMBL4795078 | 189909 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(F)cccn3c2=O)cc1 | nan | ||
| 153585386 | 190012 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4796254 | 190012 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585438 | 190139 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2c1 | nan | ||
| CHEMBL4797724 | 190139 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2c1 | nan | ||
| 153585532 | 190171 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 | nan | ||
| CHEMBL4798029 | 190171 | 0 | None | -3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 | nan | ||
| 162675990 | 190197 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 375 | 5 | 1 | 6 | 2.0 | O=C(Cn1nc2cccnn2c1=O)N[C@H](c1ccc(Cl)c(F)c1)C1CC1 | nan | ||
| CHEMBL4798509 | 190197 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 375 | 5 | 1 | 6 | 2.0 | O=C(Cn1nc2cccnn2c1=O)N[C@H](c1ccc(Cl)c(F)c1)C1CC1 | nan | ||
| 153585488 | 190246 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| CHEMBL4799144 | 190246 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| 153585707 | 190357 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 361 | 5 | 1 | 7 | 1.4 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 | nan | ||
| CHEMBL4800487 | 190357 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 361 | 5 | 1 | 7 | 1.4 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 | nan | ||
| 153585650 | 186183 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 381 | 5 | 1 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4740004 | 186183 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 381 | 5 | 1 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 162644596 | 186198 | 0 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | ||
| CHEMBL4740228 | 186198 | 0 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | ||
| 162648528 | 186593 | 0 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 337 | 5 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)cc1 | nan | ||
| CHEMBL4744984 | 186593 | 0 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 337 | 5 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)cc1 | nan | ||
| 146867363 | 186655 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 465 | 7 | 1 | 8 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(OC3CN(C)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4745642 | 186655 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 465 | 7 | 1 | 8 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(OC3CN(C)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 162649809 | 186824 | 0 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 458 | 5 | 1 | 7 | 2.1 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4747632 | 186824 | 0 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 458 | 5 | 1 | 7 | 2.1 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585543 | 187015 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1 | nan | ||
| CHEMBL4750043 | 187015 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1 | nan | ||
| 153585514 | 187152 | 0 | None | -10 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1 | nan | ||
| CHEMBL4751629 | 187152 | 0 | None | -10 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1 | nan | ||
| 153585659 | 187411 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 381 | 6 | 1 | 7 | 1.5 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)F)c(F)c1 | nan | ||
| CHEMBL4754933 | 187411 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 381 | 6 | 1 | 7 | 1.5 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(OC(F)F)c(F)c1 | nan | ||
| 153585592 | 187522 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 464 | 6 | 2 | 8 | 1.7 | C[C@H](NC(=O)Cn1nc2cccc(N3CCNCC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4755986 | 187522 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 464 | 6 | 2 | 8 | 1.7 | C[C@H](NC(=O)Cn1nc2cccc(N3CCNCC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 133916051 | 188028 | 1 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 356 | 5 | 1 | 5 | 2.4 | O=C(Cn1nc2ccccn2c1=O)NC(c1ccc(Cl)cc1)C1CC1 | nan | ||
| CHEMBL4761733 | 188028 | 1 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 356 | 5 | 1 | 5 | 2.4 | O=C(Cn1nc2ccccn2c1=O)NC(c1ccc(Cl)cc1)C1CC1 | nan | ||
| 153065968 | 188057 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 354 | 6 | 1 | 6 | 2.2 | CC(C)Oc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | ||
| CHEMBL4762154 | 188057 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 354 | 6 | 1 | 6 | 2.2 | CC(C)Oc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | ||
| 153585680 | 188065 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 314 | 4 | 1 | 5 | 1.5 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(F)cc1 | nan | ||
| CHEMBL4762210 | 188065 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 314 | 4 | 1 | 5 | 1.5 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(F)cc1 | nan | ||
| 151392727 | 188502 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 464 | 6 | 1 | 8 | 2.7 | C[C@H](NC(=O)Cn1nc2ccc(N3CCCCC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4777046 | 188502 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 464 | 6 | 1 | 8 | 2.7 | C[C@H](NC(=O)Cn1nc2ccc(N3CCCCC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 134043805 | 188548 | 1 | None | 3 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 362 | 6 | 1 | 6 | 2.0 | CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 | nan | ||
| CHEMBL4777673 | 188548 | 1 | None | 3 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 362 | 6 | 1 | 6 | 2.0 | CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 | nan | ||
| 153585533 | 188830 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 372 | 5 | 1 | 5 | 3.0 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(-c2ccccc2)cc1 | nan | ||
| CHEMBL4781160 | 188830 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 372 | 5 | 1 | 5 | 3.0 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(-c2ccccc2)cc1 | nan | ||
| 153585698 | 189200 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 331 | 4 | 1 | 6 | 1.4 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL4785855 | 189200 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 331 | 4 | 1 | 6 | 1.4 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)cc1 | nan | ||
| 149374815 | 189280 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cnccn3c2=O)cc1 | nan | ||
| CHEMBL4786952 | 189280 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cnccn3c2=O)cc1 | nan | ||
| 153585657 | 189349 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 360 | 4 | 1 | 5 | 2.1 | O=C(Cn1nc2ccc(F)cn2c1=O)NC1(c2ccc(Cl)cc2)CC1 | nan | ||
| CHEMBL4787820 | 189349 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 360 | 4 | 1 | 5 | 2.1 | O=C(Cn1nc2ccc(F)cn2c1=O)NC1(c2ccc(Cl)cc2)CC1 | nan | ||
| 121349628 | 188804 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349628 | 188804 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | nan | ||
| CHEMBL4780801 | 188804 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4780801 | 188804 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | nan | ||
| 121349739 | 188949 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 392 | 6 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)F)cc1 | nan | ||
| CHEMBL4782619 | 188949 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 392 | 6 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)F)cc1 | nan | ||
| 121349631 | 189261 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | ||
| CHEMBL4786722 | 189261 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | ||
| 122195502 | 130895 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 402 | 8 | 2 | 3 | 3.9 | COc1cccc(C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633717 | 130895 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 402 | 8 | 2 | 3 | 3.9 | COc1cccc(C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| 121349564 | 188543 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349564 | 188543 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | ||
| CHEMBL4777630 | 188543 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4777630 | 188543 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | ||
| 121349633 | 189496 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | ||
| CHEMBL4789631 | 189496 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | ||
| 164628435 | 193069 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1cccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4874254 | 193069 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1cccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| 26532940 | 130898 | 1 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | C[C@H](NC(=O)CNC(=O)c1ccc(Cl)cc1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633721 | 130898 | 1 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | C[C@H](NC(=O)CNC(=O)c1ccc(Cl)cc1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| 164621186 | 192873 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 323 | 4 | 0 | 6 | 2.4 | Cc1ccc([C@H](C)OC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4871591 | 192873 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 323 | 4 | 0 | 6 | 2.4 | Cc1ccc([C@H](C)OC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349572 | 188625 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | ||
| CHEMBL4778561 | 188625 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | ||
| 121349566 | 189431 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | ||
| CHEMBL4788831 | 189431 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | ||
| 121349806 | 190153 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| CHEMBL4797857 | 190153 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| 2114212 | 27702 | 14 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 308 | 5 | 1 | 5 | 1.2 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL1310918 | 27702 | 14 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 308 | 5 | 1 | 5 | 1.2 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349764 | 189667 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 360 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1Cl | nan | ||
| CHEMBL4792090 | 189667 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 360 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1Cl | nan | ||
| 36428174 | 188721 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4779855 | 188721 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349734 | 188875 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | nan | ||
| CHEMBL4781729 | 188875 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | nan | ||
| 121349683 | 189502 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c12 | nan | ||
| CHEMBL4789720 | 189502 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c12 | nan | ||
| 121349710 | 189727 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | ||
| CHEMBL4792828 | 189727 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | ||
| 121349767 | 190109 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4797410 | 190109 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 2303171 | 130897 | 1 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | C[C@H](NC(=O)CNC(=O)c1ccccc1Cl)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633719 | 130897 | 1 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | C[C@H](NC(=O)CNC(=O)c1ccccc1Cl)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| 121349643 | 190225 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 404 | 4 | 1 | 5 | 2.6 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1Br | nan | ||
| CHEMBL4798899 | 190225 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 404 | 4 | 1 | 5 | 2.6 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1Br | nan | ||
| 164611430 | 192003 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cn1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4857947 | 192003 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cn1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349781 | 188627 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | ||
| CHEMBL4778563 | 188627 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | ||
| 121349675 | 188744 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 390 | 4 | 1 | 5 | 3.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | ||
| CHEMBL4780038 | 188744 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 390 | 4 | 1 | 5 | 3.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | ||
| 121349763 | 189247 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 366 | 5 | 1 | 6 | 2.5 | COc1cc(C)ccc1[C@H](C)NC(=O)[C@@H](C)n1nnc2ccccc2c1=O | nan | ||
| CHEMBL4786501 | 189247 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 366 | 5 | 1 | 6 | 2.5 | COc1cc(C)ccc1[C@H](C)NC(=O)[C@@H](C)n1nnc2ccccc2c1=O | nan | ||
| 121349809 | 189940 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | ||
| CHEMBL4795372 | 189940 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | ||
| 121349689 | 189998 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | ||
| CHEMBL4796061 | 189998 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | ||
| 2548547 | 8930 | 45 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl | 10.1021/acsmedchemlett.5b00247 | ||
| 8766 | 8930 | 45 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633720 | 8930 | 45 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl | 10.1021/acsmedchemlett.5b00247 | ||
| 1555702 | 130896 | 2 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 282 | 5 | 2 | 2 | 2.3 | C[C@H](NC(=O)CNC(=O)c1ccccc1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633718 | 130896 | 2 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 282 | 5 | 2 | 2 | 2.3 | C[C@H](NC(=O)CNC(=O)c1ccccc1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| 121349597 | 188590 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(Cl)ccc3c2=O)cc1 | nan | ||
| CHEMBL4778124 | 188590 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(Cl)ccc3c2=O)cc1 | nan | ||
| 121349786 | 189032 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | nan | ||
| CHEMBL4783626 | 189032 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | nan | ||
| 28918448 | 130917 | 3 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 312 | 6 | 2 | 3 | 2.3 | COc1cccc(C(=O)NCC(=O)N[C@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633895 | 130917 | 3 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 312 | 6 | 2 | 3 | 2.3 | COc1cccc(C(=O)NCC(=O)N[C@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| 121349574 | 189598 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349574 | 189598 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | nan | ||
| CHEMBL4790968 | 189598 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4790968 | 189598 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | nan | ||
| 121349782 | 189823 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c2c1 | nan | ||
| CHEMBL4794046 | 189823 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c2c1 | nan | ||
| 121349740 | 188870 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | ||
| CHEMBL4781651 | 188870 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | ||
| 121349745 | 188991 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349745 | 188991 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | nan | ||
| CHEMBL4783071 | 188991 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4783071 | 188991 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | nan | ||
| 121349593 | 189652 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4791792 | 189652 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | ||
| 40719079 | 130909 | 1 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633885 | 130909 | 1 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| 121349656 | 190268 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 424 | 5 | 1 | 6 | 2.8 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3F)c(=O)c12 | nan | ||
| CHEMBL4799483 | 190268 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 424 | 5 | 1 | 6 | 2.8 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3F)c(=O)c12 | nan | ||
| 121349786 | 189032 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4783626 | 189032 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349593 | 189652 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | nan | ||
| CHEMBL4791792 | 189652 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | nan | ||
| 2695546 | 192895 | 12 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4871792 | 192895 | 12 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 2548543 | 130918 | 2 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | C[C@@H](NC(=O)CNC(=O)c1cccc(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633896 | 130918 | 2 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 316 | 5 | 2 | 2 | 2.9 | C[C@@H](NC(=O)CNC(=O)c1cccc(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| 11685 | 10911 | 25 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 10.1021/acs.jmedchem.1c00820 | ||
| 11685 | 10911 | 25 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | nan | ||
| 121349608 | 10911 | 25 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349608 | 10911 | 25 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | nan | ||
| CHEMBL4779773 | 10911 | 25 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4779773 | 10911 | 25 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | nan | ||
| 2714485 | 189721 | 2 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 326 | 4 | 1 | 5 | 1.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1 | nan | ||
| CHEMBL4792727 | 189721 | 2 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 326 | 4 | 1 | 5 | 1.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(F)cc1 | nan | ||
| 121349719 | 190038 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349719 | 190038 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | nan | ||
| CHEMBL4796493 | 190038 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4796493 | 190038 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | nan | ||
| 8036946 | 190218 | 2 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4798779 | 190218 | 2 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349614 | 188444 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(C)c1 | nan | ||
| CHEMBL4776329 | 188444 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(C)c1 | nan | ||
| 27783537 | 188462 | 1 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 386 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 | nan | ||
| CHEMBL4776509 | 188462 | 1 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 386 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 | nan | ||
| 121349728 | 188595 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349728 | 188595 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | nan | ||
| CHEMBL4778172 | 188595 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4778172 | 188595 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | nan | ||
| 41757362 | 188992 | 1 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | ||
| CHEMBL4783081 | 188992 | 1 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | ||
| 121349658 | 189482 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4789475 | 189482 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| 27785340 | 190250 | 1 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4799237 | 190250 | 1 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | ||
| 27754276 | 192710 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 336 | 5 | 1 | 5 | 2.4 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4869182 | 192710 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 336 | 5 | 1 | 5 | 2.4 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 7534868 | 130902 | 2 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 296 | 5 | 2 | 2 | 2.6 | Cc1cccc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633878 | 130902 | 2 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 296 | 5 | 2 | 2 | 2.6 | Cc1cccc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| 122195644 | 130912 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 334 | 5 | 2 | 2 | 3.1 | C[C@H](NC(=O)CNC(=O)c1cc(F)cc(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633888 | 130912 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 334 | 5 | 2 | 2 | 3.1 | C[C@H](NC(=O)CNC(=O)c1cc(F)cc(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| 121349701 | 188723 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc12 | nan | ||
| CHEMBL4779884 | 188723 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc12 | nan | ||
| 121349805 | 189899 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(OC)c3c2=O)cc1 | nan | ||
| CHEMBL4794908 | 189899 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(OC)c3c2=O)cc1 | nan | ||
| 121349755 | 188582 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | ||
| CHEMBL4778062 | 188582 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | ||
| 121349734 | 188875 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4781729 | 188875 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| 27785340 | 190250 | 1 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | ||
| CHEMBL4799237 | 190250 | 1 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | ||
| 122195501 | 130894 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 342 | 7 | 3 | 4 | 1.7 | COc1cccc(C(=O)N[C@@H](CO)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633716 | 130894 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 342 | 7 | 3 | 4 | 1.7 | COc1cccc(C(=O)N[C@@H](CO)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| 8036887 | 191519 | 1 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 322 | 5 | 1 | 5 | 1.7 | C[C@@H](CNC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4850747 | 191519 | 1 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 322 | 5 | 1 | 5 | 1.7 | C[C@@H](CNC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349639 | 189196 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | ||
| 121349639 | 189196 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | ||
| CHEMBL4785741 | 189196 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4785741 | 189196 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | ||
| 3341369 | 54419 | 7 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCc1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL1546963 | 54419 | 7 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCc1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349694 | 188994 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349694 | 188994 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | nan | ||
| CHEMBL4783106 | 188994 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4783106 | 188994 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | nan | ||
| 121349596 | 190220 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4798863 | 190220 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 164609046 | 191264 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 336 | 4 | 1 | 5 | 2.5 | Cc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4847108 | 191264 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 336 | 4 | 1 | 5 | 2.5 | Cc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349780 | 193148 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 322 | 5 | 1 | 5 | 1.5 | Cc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4875522 | 193148 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 322 | 5 | 1 | 5 | 1.5 | Cc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349738 | 188876 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 390 | 5 | 1 | 5 | 3.1 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| CHEMBL4781754 | 188876 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 390 | 5 | 1 | 5 | 3.1 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| 121349572 | 188625 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4778561 | 188625 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 2109722 | 130914 | 2 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 342 | 7 | 2 | 4 | 2.3 | COc1cc(OC)cc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633890 | 130914 | 2 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 342 | 7 | 2 | 4 | 2.3 | COc1cc(OC)cc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| 121349658 | 189482 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | nan | ||
| CHEMBL4789475 | 189482 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | nan | ||
| 121349548 | 190208 | 1 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 338 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4798667 | 190208 | 1 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 338 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 8036946 | 190218 | 2 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL4798779 | 190218 | 2 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | nan | ||
| 26810968 | 193062 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 358 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4874147 | 193062 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 358 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.1c00820 | ||
| 28918445 | 130905 | 1 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 312 | 6 | 2 | 3 | 2.3 | COc1cccc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633881 | 130905 | 1 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 312 | 6 | 2 | 3 | 2.3 | COc1cccc(C(=O)NCC(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| 121349633 | 189496 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4789631 | 189496 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | ||
| 121349767 | 190109 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | nan | ||
| CHEMBL4797410 | 190109 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | nan | ||
| 121349559 | 188615 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc2c1 | nan | ||
| CHEMBL4778354 | 188615 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc2c1 | nan | ||
| 121349615 | 189904 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 366 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | ||
| CHEMBL4795005 | 189904 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 366 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | ||
| 121349746 | 190163 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4797979 | 190163 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349645 | 188497 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4776988 | 188497 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 121349720 | 189022 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(OC)cccc3c2=O)cc1 | nan | ||
| CHEMBL4783544 | 189022 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(OC)cccc3c2=O)cc1 | nan | ||
| 122195642 | 130910 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633886 | 130910 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| 121349688 | 189677 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | ||
| CHEMBL4792174 | 189677 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | ||
| 121349659 | 189044 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | ||
| CHEMBL4783774 | 189044 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | ||
| 121349600 | 189364 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c2c1 | nan | ||
| CHEMBL4788013 | 189364 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c2c1 | nan | ||
| 3376937 | 130915 | 50 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 365 | 4 | 3 | 4 | 3.3 | COc1cc(OC)cc(C(=O)NNC(=O)Nc2cccc3ccccc23)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633893 | 130915 | 50 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 365 | 4 | 3 | 4 | 3.3 | COc1cc(OC)cc(C(=O)NNC(=O)Nc2cccc3ccccc23)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| 122195500 | 130893 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 326 | 6 | 2 | 3 | 2.7 | COc1cccc(C(=O)N[C@H](C)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633715 | 130893 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 326 | 6 | 2 | 3 | 2.7 | COc1cccc(C(=O)N[C@H](C)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| 121349746 | 190163 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | ||
| CHEMBL4797979 | 190163 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | ||
| 2496250 | 35725 | 7 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 338 | 6 | 1 | 6 | 1.2 | COc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL1380104 | 35725 | 7 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 338 | 6 | 1 | 6 | 1.2 | COc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 122195640 | 130907 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 366 | 6 | 2 | 3 | 3.2 | C[C@H](NC(=O)CNC(=O)c1cccc(OC(F)(F)F)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633883 | 130907 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 366 | 6 | 2 | 3 | 3.2 | C[C@H](NC(=O)CNC(=O)c1cccc(OC(F)(F)F)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| 122195643 | 130911 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1cc(Cl)cc(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633887 | 130911 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1cc(Cl)cc(Cl)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| 121349558 | 188751 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 428 | 5 | 1 | 6 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | ||
| CHEMBL4780121 | 188751 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 428 | 5 | 1 | 6 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | ||
| 121349685 | 188912 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | nan | ||
| CHEMBL4782204 | 188912 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | nan | ||
| 121349623 | 188879 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc12 | nan | ||
| CHEMBL4781805 | 188879 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc12 | nan | ||
| 121349588 | 189015 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 406 | 6 | 1 | 6 | 3.0 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4783365 | 189015 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 406 | 6 | 1 | 6 | 3.0 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 121349773 | 189207 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc2c1 | nan | ||
| CHEMBL4785980 | 189207 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc2c1 | nan | ||
| 121349793 | 188602 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 366 | 5 | 1 | 6 | 2.5 | COc1cc(C)ccc1[C@H](C)NC(=O)[C@H](C)n1nnc2ccccc2c1=O | nan | ||
| CHEMBL4778263 | 188602 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 366 | 5 | 1 | 6 | 2.5 | COc1cc(C)ccc1[C@H](C)NC(=O)[C@H](C)n1nnc2ccccc2c1=O | nan | ||
| 122195639 | 130906 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 350 | 5 | 2 | 2 | 3.3 | C[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633882 | 130906 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 350 | 5 | 2 | 2 | 3.3 | C[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| 122195641 | 130908 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1cccc(Cl)c1Cl)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633884 | 130908 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 350 | 5 | 2 | 2 | 3.6 | C[C@H](NC(=O)CNC(=O)c1cccc(Cl)c1Cl)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| 2714528 | 189257 | 2 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | nan | ||
| CHEMBL4786641 | 189257 | 2 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | nan | ||
| 2714527 | 192184 | 2 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4861019 | 192184 | 2 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349679 | 193047 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 352 | 6 | 1 | 6 | 1.5 | COc1ccc(C[C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4873905 | 193047 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 352 | 6 | 1 | 6 | 1.5 | COc1ccc(C[C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 28821961 | 130904 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 300 | 5 | 2 | 2 | 2.4 | C[C@H](NC(=O)CNC(=O)c1cccc(F)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633880 | 130904 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 300 | 5 | 2 | 2 | 2.4 | C[C@H](NC(=O)CNC(=O)c1cccc(F)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| 121349685 | 188912 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4782204 | 188912 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| 122195638 | 130903 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 307 | 5 | 2 | 3 | 2.2 | C[C@H](NC(=O)CNC(=O)c1cccc(C#N)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633879 | 130903 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 307 | 5 | 2 | 3 | 2.2 | C[C@H](NC(=O)CNC(=O)c1cccc(C#N)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| 121349795 | 190228 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | ||
| CHEMBL4798933 | 190228 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | ||
| 27838947 | 192210 | 2 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1cccc(Cl)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4861445 | 192210 | 2 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1cccc(Cl)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| 2998350 | 44878 | 6 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 334 | 3 | 1 | 5 | 2.0 | O=C(Cn1nnc2ccccc2c1=O)NC1CCCc2ccccc21 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL1460960 | 44878 | 6 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 334 | 3 | 1 | 5 | 2.0 | O=C(Cn1nnc2ccccc2c1=O)NC1CCCc2ccccc21 | 10.1021/acs.jmedchem.1c00820 | ||
| 122195499 | 130892 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 326 | 6 | 2 | 3 | 2.7 | COc1cccc(C(=O)N[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633714 | 130892 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 326 | 6 | 2 | 3 | 2.7 | COc1cccc(C(=O)N[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1021/acsmedchemlett.5b00247 | ||
| 41757362 | 188992 | 1 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4783081 | 188992 | 1 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349753 | 189673 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | nan | ||
| CHEMBL4792136 | 189673 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | nan | ||
| 2856847 | 130916 | 10 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 299 | 5 | 1 | 3 | 3.4 | CC(NC(=O)CSC(=O)c1ccccc1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633894 | 130916 | 10 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 299 | 5 | 1 | 3 | 3.4 | CC(NC(=O)CSC(=O)c1ccccc1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| 164619649 | 192545 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1Cl | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4866435 | 192545 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1Cl | 10.1021/acs.jmedchem.1c00820 | ||
| 121349671 | 188532 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 350 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | ||
| CHEMBL4777495 | 188532 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 350 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | ||
| 121349778 | 189135 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 406 | 5 | 1 | 6 | 3.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | ||
| CHEMBL4784744 | 189135 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 406 | 5 | 1 | 6 | 3.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | ||
| 121349756 | 189346 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | ||
| CHEMBL4787761 | 189346 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | ||
| 121349555 | 189416 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | ||
| CHEMBL4788631 | 189416 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | ||
| 121349787 | 189451 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | ||
| CHEMBL4789079 | 189451 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | ||
| 121349554 | 190318 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(OC)ccc3c2=O)cc1 | nan | ||
| CHEMBL4800089 | 190318 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(OC)ccc3c2=O)cc1 | nan | ||
| 164617704 | 191310 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 374 | 6 | 1 | 7 | 1.4 | COc1ccc([C@H](C)NS(=O)(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4847795 | 191310 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 374 | 6 | 1 | 7 | 1.4 | COc1ccc([C@H](C)NS(=O)(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 164617980 | 191808 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)nc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4855076 | 191808 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)nc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 122195645 | 130913 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 394 | 5 | 2 | 2 | 3.7 | C[C@H](NC(=O)CNC(=O)c1cc(Cl)cc(Br)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| CHEMBL3633889 | 130913 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 394 | 5 | 2 | 2 | 3.7 | C[C@H](NC(=O)CNC(=O)c1cc(Cl)cc(Br)c1)c1ccccc1 | 10.1021/acsmedchemlett.5b00247 | ||
| 78596259 | 192154 | 1 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | CC(NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4860510 | 192154 | 1 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | CC(NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349587 | 189191 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | ||
| CHEMBL4785669 | 189191 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | ||
| 164620660 | 192724 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 384 | 6 | 1 | 5 | 2.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(-c2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4869485 | 192724 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 384 | 6 | 1 | 5 | 2.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(-c2ccccc2)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 27783537 | 188462 | 1 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 386 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4776509 | 188462 | 1 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 386 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349569 | 188694 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | ||
| CHEMBL4779481 | 188694 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | ||
| 121349561 | 189509 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | ||
| CHEMBL4789791 | 189509 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | ||
| 121349769 | 189706 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | ||
| CHEMBL4792561 | 189706 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | ||
| 121349596 | 190220 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | ||
| CHEMBL4798863 | 190220 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | ||
| 164620725 | 192864 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.2 | COc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4871506 | 192864 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 352 | 5 | 1 | 6 | 2.2 | COc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 36428174 | 188721 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| CHEMBL4779855 | 188721 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| 121349753 | 189673 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4792136 | 189673 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| 11685 | 10911 | 25 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 34260228 | ||
| 121349608 | 10911 | 25 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 34260228 | ||
| CHEMBL4779773 | 10911 | 25 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 34260228 | ||
| 2144 | 9135 | 0 | None | - | 1 | Human | 3.5 | pEC50 | = | 3.5 | Functional | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 24826842 | ||
| 3313 | 9135 | 0 | None | - | 1 | Human | 3.5 | pEC50 | = | 3.5 | Functional | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 24826842 | ||
| 6140 | 9135 | 0 | None | - | 1 | Human | 3.5 | pEC50 | = | 3.5 | Functional | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 24826842 | ||
| 6925665 | 9135 | 0 | None | - | 1 | Human | 3.5 | pEC50 | = | 3.5 | Functional | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 24826842 | ||
| CHEMBL301523 | 9135 | 0 | None | - | 1 | Human | 3.5 | pEC50 | = | 3.5 | Functional | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 24826842 | ||
| DB00120 | 9135 | 0 | None | - | 1 | Human | 3.5 | pEC50 | = | 3.5 | Functional | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 24826842 | ||
| 2780 | 9152 | 106 | None | 13 | 2 | Human | 3.7 | pEC50 | = | 3.7 | Functional | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 24826842 | ||
| 6305 | 9152 | 106 | None | 13 | 2 | Human | 3.7 | pEC50 | = | 3.7 | Functional | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 24826842 | ||
| 6923516 | 9152 | 106 | None | 13 | 2 | Human | 3.7 | pEC50 | = | 3.7 | Functional | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 24826842 | ||
| 717 | 9152 | 106 | None | 13 | 2 | Human | 3.7 | pEC50 | = | 3.7 | Functional | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 24826842 | ||
| CHEMBL54976 | 9152 | 106 | None | 13 | 2 | Human | 3.7 | pEC50 | = | 3.7 | Functional | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 24826842 | ||
| DB00150 | 9152 | 106 | None | 13 | 2 | Human | 3.7 | pEC50 | = | 3.7 | Functional | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 24826842 | ||
| 7799 | 7798 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | Guide to Pharmacology | 365 | 4 | 3 | 4 | 3.3 | COc1cc(OC)cc(c1)C(=O)NNC(=O)Nc1ccc2c(c1)cccc2 | 24900311 | ||
| 86277840 | 7798 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | Guide to Pharmacology | 365 | 4 | 3 | 4 | 3.3 | COc1cc(OC)cc(c1)C(=O)NNC(=O)Nc1ccc2c(c1)cccc2 | 24900311 | ||
| 2144 | 9135 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Drug Central | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | None | ||
| 3313 | 9135 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Drug Central | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | None | ||
| 6140 | 9135 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Drug Central | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | None | ||
| 6925665 | 9135 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Drug Central | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | None | ||
| CHEMBL301523 | 9135 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Drug Central | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | None | ||
| DB00120 | 9135 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Drug Central | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | None | ||
| 2780 | 9152 | 106 | None | 13 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | None | ||
| 6305 | 9152 | 106 | None | 13 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | None | ||
| 6923516 | 9152 | 106 | None | 13 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | None | ||
| 717 | 9152 | 106 | None | 13 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | None | ||
| CHEMBL54976 | 9152 | 106 | None | 13 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | None | ||
| DB00150 | 9152 | 106 | None | 13 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | None | ||
| 12363 | 9527 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | Guide to Pharmacology | 340 | 1 | 1 | 3 | 4.8 | Oc1cc2c(cc1)c(=O)c(c1ccc(Cl)cc1)c(o2)C(F)(F)F | 36736525 | ||
| 5348723 | 9527 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | Guide to Pharmacology | 340 | 1 | 1 | 3 | 4.8 | Oc1cc2c(cc1)c(=O)c(c1ccc(Cl)cc1)c(o2)C(F)(F)F | 36736525 | ||
| 2144 | 9135 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | ||
| 3313 | 9135 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | ||
| 6140 | 9135 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | ||
| 6925665 | 9135 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | ||
| CHEMBL301523 | 9135 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | ||
| DB00120 | 9135 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | ||
| 2780 | 9152 | 106 | None | 13 | 2 | Human | 4.6 | pIC50 | = | 4.6 | Functional | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | ||
| 6305 | 9152 | 106 | None | 13 | 2 | Human | 4.6 | pIC50 | = | 4.6 | Functional | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | ||
| 6923516 | 9152 | 106 | None | 13 | 2 | Human | 4.6 | pIC50 | = | 4.6 | Functional | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | ||
| 717 | 9152 | 106 | None | 13 | 2 | Human | 4.6 | pIC50 | = | 4.6 | Functional | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | ||
| CHEMBL54976 | 9152 | 106 | None | 13 | 2 | Human | 4.6 | pIC50 | = | 4.6 | Functional | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | ||
| DB00150 | 9152 | 106 | None | 13 | 2 | Human | 4.6 | pIC50 | = | 4.6 | Functional | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | ||
| 789353 | 9133 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | 329 | 4 | 1 | 2 | 4.8 | Cc1ccccc1NS(=O)(=O)c1ccc(cc1)C1CCCCC1 | 19525486 | ||
| 8774 | 9133 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | 329 | 4 | 1 | 2 | 4.8 | Cc1ccccc1NS(=O)(=O)c1ccc(cc1)C1CCCCC1 | 19525486 | ||
| 5017692 | 9526 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | Guide to Pharmacology | 289 | 3 | 0 | 2 | 3.4 | COc1ccc(cc1)C1N(c2ccccc2)C(=O)C1(F)F | 26027661 | ||
| 8775 | 9526 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | Guide to Pharmacology | 289 | 3 | 0 | 2 | 3.4 | COc1ccc(cc1)C1N(c2ccccc2)C(=O)C1(F)F | 26027661 | ||
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 153585580 | 186223 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| CHEMBL4740491 | 186223 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| 148397968 | 186414 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | ||
| CHEMBL4742901 | 186414 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | ||
| 153585666 | 186416 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 378 | 5 | 1 | 6 | 2.2 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | ||
| CHEMBL4742949 | 186416 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 378 | 5 | 1 | 6 | 2.2 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | ||
| 147451915 | 186466 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4743612 | 186466 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585625 | 186472 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(C)ccn3c2=O)cc1 | nan | ||
| CHEMBL4743662 | 186472 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(C)ccn3c2=O)cc1 | nan | ||
| 153585420 | 186589 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 364 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL4744927 | 186589 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 364 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| 153585722 | 186726 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 394 | 5 | 1 | 6 | 2.6 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| CHEMBL4746401 | 186726 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 394 | 5 | 1 | 6 | 2.6 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| 162649907 | 186862 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 378 | 5 | 2 | 7 | 1.6 | CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | ||
| CHEMBL4748076 | 186862 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 378 | 5 | 2 | 7 | 1.6 | CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | ||
| 152844759 | 186878 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ncc(C3CC3)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4748306 | 186878 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ncc(C3CC3)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585686 | 187032 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | nan | ||
| CHEMBL4750288 | 187032 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | nan | ||
| 147641221 | 187075 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1 | nan | ||
| CHEMBL4750914 | 187075 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1 | nan | ||
| 153585718 | 187120 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4751304 | 187120 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585581 | 187141 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2ccc(C#N)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4751501 | 187141 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2ccc(C#N)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585708 | 187236 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL4752808 | 187236 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)cc1 | nan | ||
| 153585648 | 187296 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 366 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4753388 | 187296 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 366 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162653764 | 187312 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2cc(C3CC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4753640 | 187312 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2cc(C3CC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585540 | 187387 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 398 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4754565 | 187387 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 398 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585467 | 187388 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 | nan | ||
| CHEMBL4754576 | 187388 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 | nan | ||
| 152015494 | 187402 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2c(C3CC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4754735 | 187402 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2c(C3CC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 150352344 | 187550 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4756243 | 187550 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162655689 | 187562 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | ||
| CHEMBL4756356 | 187562 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | ||
| 153585712 | 187570 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 419 | 6 | 2 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(NC3COC3)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4756431 | 187570 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 419 | 6 | 2 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(NC3COC3)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585415 | 187667 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O | nan | ||
| CHEMBL4757506 | 187667 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O | nan | ||
| 153585630 | 187774 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 346 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(F)cn3c2=O)cc1F | nan | ||
| CHEMBL4758841 | 187774 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 346 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(F)cn3c2=O)cc1F | nan | ||
| 153585534 | 187863 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 413 | 5 | 1 | 7 | 2.1 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 | nan | ||
| CHEMBL4759991 | 187863 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 413 | 5 | 1 | 7 | 2.1 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 | nan | ||
| 153585651 | 187981 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 382 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nc2cc(Cl)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4761154 | 187981 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 382 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nc2cc(Cl)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585591 | 188055 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)ccc1Cl | nan | ||
| CHEMBL4762126 | 188055 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)ccc1Cl | nan | ||
| 162659465 | 188099 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | ||
| CHEMBL4762651 | 188099 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | ||
| 153585610 | 188224 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O | nan | ||
| CHEMBL4764290 | 188224 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O | nan | ||
| 153585689 | 188285 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2c1 | nan | ||
| CHEMBL4764967 | 188285 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2c1 | nan | ||
| 162661302 | 188296 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 383 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4765018 | 188296 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 383 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585427 | 188760 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(C)cn3c2=O)cc1 | nan | ||
| CHEMBL4780358 | 188760 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(C)cn3c2=O)cc1 | nan | ||
| 153585638 | 188979 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | ||
| CHEMBL4782901 | 188979 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | ||
| 153585409 | 189250 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 394 | 5 | 1 | 6 | 2.6 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 | nan | ||
| CHEMBL4786542 | 189250 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 394 | 5 | 1 | 6 | 2.6 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 | nan | ||
| 147410414 | 189460 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 | nan | ||
| CHEMBL4789252 | 189460 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 | nan | ||
| 153585385 | 189596 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 360 | 5 | 1 | 6 | 2.0 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 | nan | ||
| CHEMBL4790949 | 189596 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 360 | 5 | 1 | 6 | 2.0 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 | nan | ||
| 162671538 | 189608 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 417 | 4 | 1 | 6 | 2.6 | C[C@H](NC(=O)Cn1nc2c(C(F)(F)F)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4791193 | 189608 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 417 | 4 | 1 | 6 | 2.6 | C[C@H](NC(=O)Cn1nc2c(C(F)(F)F)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162671011 | 189723 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 | nan | ||
| CHEMBL4792732 | 189723 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 | nan | ||
| 148156995 | 189734 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 460 | 8 | 2 | 8 | 2.3 | C[C@H](NC(=O)Cn1nc2c(NCC(F)F)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4792896 | 189734 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 460 | 8 | 2 | 8 | 2.3 | C[C@H](NC(=O)Cn1nc2c(NCC(F)F)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 151533016 | 189749 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 339 | 5 | 2 | 6 | 1.7 | CNc1cccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc12 | nan | ||
| CHEMBL4793093 | 189749 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 339 | 5 | 2 | 6 | 1.7 | CNc1cccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc12 | nan | ||
| 153585429 | 190191 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n12 | nan | ||
| CHEMBL4798385 | 190191 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n12 | nan | ||
| 153585699 | 190280 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 362 | 4 | 1 | 5 | 2.5 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | ||
| CHEMBL4799647 | 190280 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 362 | 4 | 1 | 5 | 2.5 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | ||
| 153585528 | 190343 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1Cl | nan | ||
| CHEMBL4800338 | 190343 | 0 | None | - | 0 | Human | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1Cl | nan | ||
| 162644596 | 186198 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | ||
| CHEMBL4740228 | 186198 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | ||
| 153585418 | 186226 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 434 | 5 | 1 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4740519 | 186226 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 434 | 5 | 1 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585684 | 186312 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 377 | 4 | 1 | 6 | 2.2 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | ||
| CHEMBL4741467 | 186312 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 377 | 4 | 1 | 6 | 2.2 | Cc1cc(C)n2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | ||
| 152956498 | 186489 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 324 | 4 | 1 | 5 | 2.2 | Cc1ccc([C@H](C)NC(=O)C(C)n2nc3ccccn3c2=O)cc1 | nan | ||
| CHEMBL4743938 | 186489 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 324 | 4 | 1 | 5 | 2.2 | Cc1ccc([C@H](C)NC(=O)C(C)n2nc3ccccn3c2=O)cc1 | nan | ||
| 153585688 | 186537 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4744340 | 186537 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 162648790 | 186566 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | ||
| CHEMBL4744737 | 186566 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | ||
| 153585420 | 186589 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 364 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL4744927 | 186589 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 364 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| 162647825 | 186614 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | ||
| CHEMBL4745096 | 186614 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | ||
| 152005060 | 186641 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 447 | 5 | 1 | 8 | 1.3 | C[C@H](NC(=O)Cn1nc2c(N3CCN(C)CC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4745432 | 186641 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 447 | 5 | 1 | 8 | 1.3 | C[C@H](NC(=O)Cn1nc2c(N3CCN(C)CC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 150995037 | 186698 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cnccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4746108 | 186698 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cnccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585512 | 186807 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 367 | 4 | 1 | 6 | 1.7 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4747431 | 186807 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 367 | 4 | 1 | 6 | 1.7 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162650006 | 186904 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2cccnn2c1=O | nan | ||
| CHEMBL4748681 | 186904 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2cccnn2c1=O | nan | ||
| 151976938 | 187019 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | ||
| CHEMBL4750143 | 187019 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | ||
| 153585686 | 187032 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | nan | ||
| CHEMBL4750288 | 187032 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | nan | ||
| 147634500 | 187057 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F | nan | ||
| CHEMBL4750692 | 187057 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F | nan | ||
| 147641221 | 187075 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1 | nan | ||
| CHEMBL4750914 | 187075 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1 | nan | ||
| 153585718 | 187120 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4751304 | 187120 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585721 | 187130 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 383 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2ncc(Cl)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4751414 | 187130 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 383 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2ncc(Cl)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585581 | 187141 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2ccc(C#N)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4751501 | 187141 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2ccc(C#N)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585514 | 187152 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1 | nan | ||
| CHEMBL4751629 | 187152 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 311 | 4 | 1 | 6 | 1.1 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1 | nan | ||
| 153585541 | 187160 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 341 | 5 | 1 | 7 | 1.1 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2n1 | nan | ||
| CHEMBL4751720 | 187160 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 341 | 5 | 1 | 7 | 1.1 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc2n1 | nan | ||
| 162653366 | 187239 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 410 | 6 | 2 | 8 | 1.7 | CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 | nan | ||
| CHEMBL4752829 | 187239 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 410 | 6 | 2 | 8 | 1.7 | CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 | nan | ||
| 153585655 | 187255 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 493 | 7 | 1 | 8 | 2.9 | COC1CCN(c2ccn3c(=O)n(CC(=O)N[C@@H](C)c4ccc(OC(F)(F)F)cc4)nc3c2)CC1 | nan | ||
| CHEMBL4752993 | 187255 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 493 | 7 | 1 | 8 | 2.9 | COC1CCN(c2ccn3c(=O)n(CC(=O)N[C@@H](C)c4ccc(OC(F)(F)F)cc4)nc3c2)CC1 | nan | ||
| 153585421 | 187300 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 447 | 5 | 1 | 7 | 2.4 | CC1COCCN1c1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 | nan | ||
| CHEMBL4753419 | 187300 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 447 | 5 | 1 | 7 | 2.4 | CC1COCCN1c1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 | nan | ||
| 147378727 | 187306 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 380 | 6 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)c(F)c1 | nan | ||
| CHEMBL4753547 | 187306 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 380 | 6 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)c(F)c1 | nan | ||
| 162653797 | 187309 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F | nan | ||
| CHEMBL4753587 | 187309 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F | nan | ||
| 148512747 | 187336 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1nccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 | nan | ||
| CHEMBL4753915 | 187336 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1nccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 | nan | ||
| 149101043 | 187382 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4754476 | 187382 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585478 | 187384 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4754503 | 187384 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585540 | 187387 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 398 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4754565 | 187387 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 398 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585445 | 187536 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 382 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| CHEMBL4756137 | 187536 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 382 | 4 | 1 | 5 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| 94095050 | 187590 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 380 | 5 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4756787 | 187590 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 380 | 5 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 162657043 | 187601 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2n1 | nan | ||
| CHEMBL4756879 | 187601 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2n1 | nan | ||
| 162656575 | 187662 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | ||
| CHEMBL4757480 | 187662 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | ||
| 162656504 | 187675 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4757619 | 187675 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 152460205 | 187713 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 451 | 6 | 2 | 8 | 1.5 | C[C@H](NC(=O)Cn1nc2cccc(N3CC(O)C3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4758096 | 187713 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 451 | 6 | 2 | 8 | 1.5 | C[C@H](NC(=O)Cn1nc2cccc(N3CC(O)C3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585448 | 187729 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2n1 | nan | ||
| CHEMBL4758322 | 187729 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2n1 | nan | ||
| 149421402 | 187735 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 452 | 7 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(OC3COC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4758375 | 187735 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 452 | 7 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(OC3COC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 162657688 | 187834 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)ccc1Cl | nan | ||
| CHEMBL4759611 | 187834 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)ccc1Cl | nan | ||
| 162657416 | 187899 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | ||
| CHEMBL4760528 | 187899 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | ||
| 150924716 | 187945 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1cccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc12 | nan | ||
| CHEMBL4760914 | 187945 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1cccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nc12 | nan | ||
| 153585574 | 188000 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4761321 | 188000 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162660420 | 188054 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 5 | 1 | 6 | 2.0 | CC[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4762121 | 188054 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 5 | 1 | 6 | 2.0 | CC[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585591 | 188055 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)ccc1Cl | nan | ||
| CHEMBL4762126 | 188055 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)ccc1Cl | nan | ||
| 147987797 | 188063 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| CHEMBL4762206 | 188063 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| 147323186 | 188163 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 325 | 4 | 1 | 6 | 1.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cnc(C)cn3c2=O)cc1 | nan | ||
| CHEMBL4763362 | 188163 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 325 | 4 | 1 | 6 | 1.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cnc(C)cn3c2=O)cc1 | nan | ||
| 153585610 | 188224 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O | nan | ||
| CHEMBL4764290 | 188224 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ccccn2c1=O | nan | ||
| 162661581 | 188243 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 362 | 4 | 1 | 5 | 2.7 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O | nan | ||
| CHEMBL4764506 | 188243 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 362 | 4 | 1 | 5 | 2.7 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O | nan | ||
| 152494840 | 188276 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC(O)CC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4764839 | 188276 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC(O)CC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 162661302 | 188296 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 383 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4765018 | 188296 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 383 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(Cl)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585547 | 188520 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4777214 | 188520 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162644369 | 188609 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 343 | 4 | 1 | 6 | 1.5 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(C)ccnn3c2=O)cc1F | nan | ||
| CHEMBL4778327 | 188609 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 343 | 4 | 1 | 6 | 1.5 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(C)ccnn3c2=O)cc1F | nan | ||
| 162665057 | 188845 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL4781404 | 188845 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| 150561998 | 188910 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 475 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2c(I)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4782195 | 188910 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 475 | 4 | 1 | 6 | 2.2 | C[C@H](NC(=O)Cn1nc2c(I)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 149618414 | 189040 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 325 | 4 | 2 | 6 | 1.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(N)cccn3c2=O)cc1 | nan | ||
| CHEMBL4783739 | 189040 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 325 | 4 | 2 | 6 | 1.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(N)cccn3c2=O)cc1 | nan | ||
| 153585463 | 189186 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 433 | 5 | 1 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2cccc(N3CCOCC3)n2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4785639 | 189186 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 433 | 5 | 1 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2cccc(N3CCOCC3)n2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585417 | 189206 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1Cl | nan | ||
| CHEMBL4785963 | 189206 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1Cl | nan | ||
| 153585609 | 189251 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 465 | 6 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4786573 | 189251 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 465 | 6 | 1 | 8 | 2.1 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 151394869 | 189315 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4787308 | 189315 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585701 | 189332 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 463 | 6 | 1 | 7 | 3.3 | C[C@H](NC(=O)Cn1nc2cccc(N3CCCCC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4787547 | 189332 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 463 | 6 | 1 | 7 | 3.3 | C[C@H](NC(=O)Cn1nc2cccc(N3CCCCC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 151043804 | 189454 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4789123 | 189454 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162670176 | 189530 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 377 | 5 | 1 | 6 | 2.2 | CC(C)[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4790080 | 189530 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 377 | 5 | 1 | 6 | 2.2 | CC(C)[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585385 | 189596 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 360 | 5 | 1 | 6 | 2.0 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 | nan | ||
| CHEMBL4790949 | 189596 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 360 | 5 | 1 | 6 | 2.0 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n12 | nan | ||
| 153585679 | 189702 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F | nan | ||
| CHEMBL4792515 | 189702 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F | nan | ||
| 162671011 | 189723 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 | nan | ||
| CHEMBL4792732 | 189723 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)c(=O)n2n1 | nan | ||
| 148156995 | 189734 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 460 | 8 | 2 | 8 | 2.3 | C[C@H](NC(=O)Cn1nc2c(NCC(F)F)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4792896 | 189734 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 460 | 8 | 2 | 8 | 2.3 | C[C@H](NC(=O)Cn1nc2c(NCC(F)F)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585524 | 189909 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(F)cccn3c2=O)cc1 | nan | ||
| CHEMBL4795078 | 189909 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(F)cccn3c2=O)cc1 | nan | ||
| 153585504 | 189990 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| CHEMBL4795956 | 189990 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| 153585386 | 190012 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4796254 | 190012 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585438 | 190139 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2c1 | nan | ||
| CHEMBL4797724 | 190139 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2c1 | nan | ||
| 153585532 | 190171 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 | nan | ||
| CHEMBL4798029 | 190171 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 | nan | ||
| 153585429 | 190191 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n12 | nan | ||
| CHEMBL4798385 | 190191 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 340 | 5 | 1 | 6 | 1.7 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)n12 | nan | ||
| 153585528 | 190343 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1Cl | nan | ||
| CHEMBL4800338 | 190343 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1Cl | nan | ||
| 153585707 | 190357 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 361 | 5 | 1 | 7 | 1.4 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 | nan | ||
| CHEMBL4800487 | 190357 | 0 | None | - | 0 | Rat | 9.0 | pEC50 | = | 9 | Binding | ChEMBL | 361 | 5 | 1 | 7 | 1.4 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)cc3)nc2n1 | nan | ||
| 162644596 | 186198 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | ||
| CHEMBL4740228 | 186198 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | ||
| 162648790 | 186566 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | ||
| CHEMBL4744737 | 186566 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | ||
| 162647825 | 186614 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | ||
| CHEMBL4745096 | 186614 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | ||
| 162649809 | 186824 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 458 | 5 | 1 | 7 | 2.1 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4747632 | 186824 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 458 | 5 | 1 | 7 | 2.1 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 151976938 | 187019 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | ||
| CHEMBL4750143 | 187019 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | ||
| 147634500 | 187057 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F | nan | ||
| CHEMBL4750692 | 187057 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F | nan | ||
| 149094095 | 187061 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 421 | 6 | 1 | 7 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4750718 | 187061 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 421 | 6 | 1 | 7 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 162653366 | 187239 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 410 | 6 | 2 | 8 | 1.7 | CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 | nan | ||
| CHEMBL4752829 | 187239 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 410 | 6 | 2 | 8 | 1.7 | CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc12 | nan | ||
| 162653797 | 187309 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F | nan | ||
| CHEMBL4753587 | 187309 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccnn3c2=O)cc1F | nan | ||
| 152007746 | 187345 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 368 | 5 | 1 | 6 | 2.3 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3c(C)cc(C)cc3C)nc2c1 | nan | ||
| CHEMBL4754043 | 187345 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 368 | 5 | 1 | 6 | 2.3 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3c(C)cc(C)cc3C)nc2c1 | nan | ||
| 153585713 | 187750 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(F)cn3c2=O)cc1 | nan | ||
| CHEMBL4758561 | 187750 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(F)cn3c2=O)cc1 | nan | ||
| 153585574 | 188000 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4761321 | 188000 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)[C@@H](C)n1nc2ncccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 147987797 | 188063 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| CHEMBL4762206 | 188063 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 364 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| 162661581 | 188243 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 362 | 4 | 1 | 5 | 2.7 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O | nan | ||
| CHEMBL4764506 | 188243 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 362 | 4 | 1 | 5 | 2.7 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ccccn2c1=O | nan | ||
| 153585547 | 188520 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4777214 | 188520 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 420 | 6 | 2 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162644369 | 188609 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 343 | 4 | 1 | 6 | 1.5 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(C)ccnn3c2=O)cc1F | nan | ||
| CHEMBL4778327 | 188609 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 343 | 4 | 1 | 6 | 1.5 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(C)ccnn3c2=O)cc1F | nan | ||
| 162665057 | 188845 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL4781404 | 188845 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| 151043804 | 189454 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4789123 | 189454 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585679 | 189702 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F | nan | ||
| CHEMBL4792515 | 189702 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 329 | 4 | 1 | 6 | 1.2 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1F | nan | ||
| 162670606 | 189717 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2n1 | nan | ||
| CHEMBL4792682 | 189717 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n2n1 | nan | ||
| 153585386 | 190012 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4796254 | 190012 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 415 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(Cl)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585532 | 190171 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 | nan | ||
| CHEMBL4798029 | 190171 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 328 | 4 | 1 | 5 | 1.8 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(F)n3c2=O)cc1 | nan | ||
| 147477854 | 190277 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 433 | 5 | 1 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2c(N3CCOCC3)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4799618 | 190277 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 433 | 5 | 1 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2c(N3CCOCC3)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162644596 | 186198 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | ||
| CHEMBL4740228 | 186198 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | ||
| 162648528 | 186593 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 337 | 5 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)cc1 | nan | ||
| CHEMBL4744984 | 186593 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 337 | 5 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(C2CC2)cc1 | nan | ||
| 146976458 | 186809 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 507 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2c(I)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4747440 | 186809 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 507 | 5 | 1 | 7 | 2.3 | C[C@H](NC(=O)Cn1nc2c(I)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 162649809 | 186824 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 458 | 5 | 1 | 7 | 2.1 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4747632 | 186824 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 458 | 5 | 1 | 7 | 2.1 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CN(C)C4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 152844759 | 186878 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ncc(C3CC3)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4748306 | 186878 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ncc(C3CC3)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585550 | 187172 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | ||
| CHEMBL4751886 | 187172 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 355 | 5 | 1 | 6 | 1.8 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(C2CC2)c(F)c1 | nan | ||
| 152007746 | 187345 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 368 | 5 | 1 | 6 | 2.3 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3c(C)cc(C)cc3C)nc2c1 | nan | ||
| CHEMBL4754043 | 187345 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 368 | 5 | 1 | 6 | 2.3 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3c(C)cc(C)cc3C)nc2c1 | nan | ||
| 153585588 | 187565 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 444 | 5 | 2 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CNC4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4756392 | 187565 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 444 | 5 | 2 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2c(N3CCC34CNC4)cccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585575 | 187608 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 433 | 5 | 2 | 8 | 1.0 | C[C@H](NC(=O)Cn1nc2c(N3CCNCC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4756937 | 187608 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 433 | 5 | 2 | 8 | 1.0 | C[C@H](NC(=O)Cn1nc2c(N3CCNCC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585415 | 187667 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O | nan | ||
| CHEMBL4757506 | 187667 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O | nan | ||
| 153585534 | 187863 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 413 | 5 | 1 | 7 | 2.1 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 | nan | ||
| CHEMBL4759991 | 187863 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 413 | 5 | 1 | 7 | 2.1 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 | nan | ||
| 153585663 | 187934 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1Cl | nan | ||
| CHEMBL4760812 | 187934 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ncccn3c2=O)cc1Cl | nan | ||
| 153585643 | 188120 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 381 | 5 | 1 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4762957 | 188120 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 381 | 5 | 1 | 7 | 1.7 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 134043805 | 188548 | 1 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 362 | 6 | 1 | 6 | 2.0 | CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 | nan | ||
| CHEMBL4777673 | 188548 | 1 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 362 | 6 | 1 | 6 | 2.0 | CC(NC(=O)Cn1nc2ccccn2c1=O)c1ccc(OC(F)F)cc1 | nan | ||
| 153585542 | 189085 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL4784153 | 189085 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 365 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nc2ncccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| 162667558 | 189241 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 331 | 4 | 1 | 6 | 1.4 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL4786371 | 189241 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 331 | 4 | 1 | 6 | 1.4 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(Cl)cc1 | nan | ||
| 147410414 | 189460 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 | nan | ||
| CHEMBL4789252 | 189460 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccnc2nn(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)c(=O)n12 | nan | ||
| 121349671 | 188532 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 350 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | ||
| CHEMBL4777495 | 188532 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 350 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | ||
| 121349806 | 190153 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| CHEMBL4797857 | 190153 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| 121349656 | 190268 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 424 | 5 | 1 | 6 | 2.8 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3F)c(=O)c12 | nan | ||
| CHEMBL4799483 | 190268 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 424 | 5 | 1 | 6 | 2.8 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3F)c(=O)c12 | nan | ||
| 121349756 | 189346 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | ||
| CHEMBL4787761 | 189346 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | ||
| 27785340 | 190250 | 1 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4799237 | 190250 | 1 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | ||
| 27785340 | 190250 | 1 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | ||
| CHEMBL4799237 | 190250 | 1 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | ||
| 121349782 | 189823 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c2c1 | nan | ||
| CHEMBL4794046 | 189823 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c2c1 | nan | ||
| 164619649 | 192545 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1Cl | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4866435 | 192545 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccccc1Cl | 10.1021/acs.jmedchem.1c00820 | ||
| 26810968 | 193062 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 358 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4874147 | 193062 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 358 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1cccc2ccccc12 | 10.1021/acs.jmedchem.1c00820 | ||
| 11685 | 10911 | 25 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349608 | 10911 | 25 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4779773 | 10911 | 25 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 10.1021/acs.jmedchem.1c00820 | ||
| 11685 | 10911 | 25 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | nan | ||
| 121349608 | 10911 | 25 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | nan | ||
| CHEMBL4779773 | 10911 | 25 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | nan | ||
| 121349786 | 189032 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4783626 | 189032 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349639 | 189196 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4785741 | 189196 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | ||
| 121349786 | 189032 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | nan | ||
| CHEMBL4783626 | 189032 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 404 | 7 | 1 | 7 | 2.3 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12 | nan | ||
| 121349639 | 189196 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | ||
| CHEMBL4785741 | 189196 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | ||
| 2695546 | 192895 | 12 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4871792 | 192895 | 12 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349600 | 189364 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c2c1 | nan | ||
| CHEMBL4788013 | 189364 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c2c1 | nan | ||
| 121349548 | 190208 | 1 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 338 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4798667 | 190208 | 1 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 338 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349548 | 190208 | 1 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 338 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | ||
| CHEMBL4798667 | 190208 | 1 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 338 | 5 | 1 | 6 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | ||
| 121349554 | 190318 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(OC)ccc3c2=O)cc1 | nan | ||
| CHEMBL4800089 | 190318 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(OC)ccc3c2=O)cc1 | nan | ||
| 36428174 | 188721 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4779855 | 188721 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 36428174 | 188721 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| CHEMBL4779855 | 188721 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 376 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| 121349659 | 189044 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | ||
| CHEMBL4783774 | 189044 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | ||
| 121349593 | 189652 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4791792 | 189652 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | 10.1021/acs.jmedchem.1c00820 | ||
| 121349593 | 189652 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | nan | ||
| CHEMBL4791792 | 189652 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 394 | 4 | 1 | 5 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1F | nan | ||
| 121349633 | 189496 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4789631 | 189496 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | 10.1021/acs.jmedchem.1c00820 | ||
| 121349633 | 189496 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | ||
| CHEMBL4789631 | 189496 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O | nan | ||
| 2714527 | 192184 | 2 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4861019 | 192184 | 2 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 2714528 | 189257 | 2 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | nan | ||
| CHEMBL4786641 | 189257 | 2 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 308 | 4 | 1 | 5 | 1.7 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | nan | ||
| 27838947 | 192210 | 2 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1cccc(Cl)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4861445 | 192210 | 2 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 342 | 5 | 1 | 5 | 1.8 | O=C(Cn1nnc2ccccc2c1=O)NCCc1cccc(Cl)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349658 | 189482 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4789475 | 189482 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349658 | 189482 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | nan | ||
| CHEMBL4789475 | 189482 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(F)c1 | nan | ||
| 121349597 | 188590 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(Cl)ccc3c2=O)cc1 | nan | ||
| CHEMBL4778124 | 188590 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(Cl)ccc3c2=O)cc1 | nan | ||
| 121349631 | 189261 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4786722 | 189261 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349631 | 189261 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | ||
| CHEMBL4786722 | 189261 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | ||
| 121349615 | 189904 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 366 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | ||
| CHEMBL4795005 | 189904 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 366 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cc(C)cc3c2=O)cc1 | nan | ||
| 121349564 | 188543 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4777630 | 188543 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349564 | 188543 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | ||
| CHEMBL4777630 | 188543 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | ||
| 121349588 | 189015 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 406 | 6 | 1 | 6 | 3.0 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4783365 | 189015 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 406 | 6 | 1 | 6 | 3.0 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 121349572 | 188625 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4778561 | 188625 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349572 | 188625 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | ||
| CHEMBL4778561 | 188625 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 356 | 4 | 1 | 5 | 2.6 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | ||
| 121349778 | 189135 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 3.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | ||
| CHEMBL4784744 | 189135 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 3.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | ||
| 164617980 | 191808 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)nc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4855076 | 191808 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)nc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349738 | 188876 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 390 | 5 | 1 | 5 | 3.1 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| CHEMBL4781754 | 188876 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 390 | 5 | 1 | 5 | 3.1 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cc1 | nan | ||
| 121349559 | 188615 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc2c1 | nan | ||
| CHEMBL4778354 | 188615 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc2c1 | nan | ||
| 164628435 | 193069 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1cccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4874254 | 193069 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1cccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| 8036946 | 190218 | 2 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4798779 | 190218 | 2 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 8036946 | 190218 | 2 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL4798779 | 190218 | 2 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | nan | ||
| 121349701 | 188723 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc12 | nan | ||
| CHEMBL4779884 | 188723 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nnc12 | nan | ||
| 121349710 | 189727 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | ||
| CHEMBL4792828 | 189727 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | ||
| 121349675 | 188744 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 390 | 4 | 1 | 5 | 3.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | ||
| CHEMBL4780038 | 188744 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 390 | 4 | 1 | 5 | 3.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cc(Cl)cc3c2=O)cc1 | nan | ||
| 121349683 | 189502 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c12 | nan | ||
| CHEMBL4789720 | 189502 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)c(=O)c12 | nan | ||
| 121349753 | 189673 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4792136 | 189673 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349753 | 189673 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | nan | ||
| CHEMBL4792136 | 189673 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1 | nan | ||
| 78596259 | 192154 | 1 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | CC(NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4860510 | 192154 | 1 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 342 | 4 | 1 | 5 | 2.3 | CC(NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349739 | 188949 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 392 | 6 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)F)cc1 | nan | ||
| CHEMBL4782619 | 188949 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 392 | 6 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)F)cc1 | nan | ||
| 2496250 | 35725 | 7 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 338 | 6 | 1 | 6 | 1.2 | COc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL1380104 | 35725 | 7 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 338 | 6 | 1 | 6 | 1.2 | COc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349685 | 188912 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4782204 | 188912 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349685 | 188912 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | nan | ||
| CHEMBL4782204 | 188912 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 440 | 6 | 1 | 7 | 2.7 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12 | nan | ||
| 121349719 | 190038 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | nan | ||
| CHEMBL4796493 | 190038 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | nan | ||
| 121349787 | 189451 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | ||
| CHEMBL4789079 | 189451 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cc(C)ccc3c2=O)cc1 | nan | ||
| 121349623 | 188879 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc12 | nan | ||
| CHEMBL4781805 | 188879 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc12 | nan | ||
| 121349755 | 188582 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | ||
| CHEMBL4778062 | 188582 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | ||
| 121349773 | 189207 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc2c1 | nan | ||
| CHEMBL4785980 | 189207 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 406 | 5 | 1 | 6 | 2.7 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C(F)(F)F)cc3)nnc2c1 | nan | ||
| 121349614 | 188444 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(C)c1 | nan | ||
| CHEMBL4776329 | 188444 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(C)c1 | nan | ||
| 121349720 | 189022 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(OC)cccc3c2=O)cc1 | nan | ||
| CHEMBL4783544 | 189022 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(OC)cccc3c2=O)cc1 | nan | ||
| 121349645 | 188497 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4776988 | 188497 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 5 | 1 | 6 | 2.7 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 164611430 | 192003 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cn1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4857947 | 192003 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 377 | 4 | 1 | 6 | 2.1 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C(F)(F)F)cn1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349746 | 190163 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4797979 | 190163 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349746 | 190163 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | ||
| CHEMBL4797979 | 190163 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 390 | 4 | 1 | 5 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C(F)(F)F)cc3c2=O)cc1 | nan | ||
| 121349745 | 188991 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4783071 | 188991 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349745 | 188991 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | nan | ||
| CHEMBL4783071 | 188991 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc2c1 | nan | ||
| 8036887 | 191519 | 1 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 322 | 5 | 1 | 5 | 1.7 | C[C@@H](CNC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4850747 | 191519 | 1 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 322 | 5 | 1 | 5 | 1.7 | C[C@@H](CNC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349781 | 188627 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | ||
| CHEMBL4778563 | 188627 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | ||
| 121349596 | 190220 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4798863 | 190220 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349596 | 190220 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | ||
| CHEMBL4798863 | 190220 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 322 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | ||
| 121349728 | 188595 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4778172 | 188595 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349728 | 188595 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | nan | ||
| CHEMBL4778172 | 188595 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12 | nan | ||
| 121349688 | 189677 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | ||
| CHEMBL4792174 | 189677 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(F)c3c2=O)cc1 | nan | ||
| 27783537 | 188462 | 1 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 386 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4776509 | 188462 | 1 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 386 | 4 | 1 | 5 | 2.4 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Br)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349587 | 189191 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | ||
| CHEMBL4785669 | 189191 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | ||
| 121349769 | 189706 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | ||
| CHEMBL4792561 | 189706 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | ||
| 121349689 | 189998 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | ||
| CHEMBL4796061 | 189998 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(Cl)cc3c2=O)cc1 | nan | ||
| 121349780 | 193148 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 322 | 5 | 1 | 5 | 1.5 | Cc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4875522 | 193148 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 322 | 5 | 1 | 5 | 1.5 | Cc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349628 | 188804 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4780801 | 188804 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349628 | 188804 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | nan | ||
| CHEMBL4780801 | 188804 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1 | nan | ||
| 121349805 | 189899 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(OC)c3c2=O)cc1 | nan | ||
| CHEMBL4794908 | 189899 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 368 | 6 | 1 | 7 | 1.7 | COc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(OC)c3c2=O)cc1 | nan | ||
| 27754276 | 192710 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 336 | 5 | 1 | 5 | 2.4 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4869182 | 192710 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 336 | 5 | 1 | 5 | 2.4 | CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349734 | 188875 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4781729 | 188875 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349734 | 188875 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | nan | ||
| CHEMBL4781729 | 188875 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(C)c1 | nan | ||
| 121349574 | 189598 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4790968 | 189598 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349574 | 189598 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | nan | ||
| CHEMBL4790968 | 189598 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 374 | 6 | 1 | 6 | 2.3 | C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1 | nan | ||
| 121349569 | 188694 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | ||
| CHEMBL4779481 | 188694 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 340 | 4 | 1 | 5 | 2.1 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cccc3c2=O)cc1 | nan | ||
| 164609046 | 191264 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.5 | Cc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4847108 | 191264 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.5 | Cc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349561 | 189509 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | ||
| CHEMBL4789791 | 189509 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(C)cccc3c2=O)cc1 | nan | ||
| 121349719 | 190038 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4796493 | 190038 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 422 | 6 | 1 | 7 | 2.6 | COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349711 | 189646 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 358 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(F)c1 | nan | ||
| CHEMBL4791752 | 189646 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 358 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)c(F)c1 | nan | ||
| 121349694 | 188994 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4783106 | 188994 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349694 | 188994 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | nan | ||
| CHEMBL4783106 | 188994 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1cccc2c(=O)n(CC(=O)N[C@@H](C)c3ccc(C)cc3)nnc12 | nan | ||
| 121349679 | 193047 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 352 | 6 | 1 | 6 | 1.5 | COc1ccc(C[C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4873905 | 193047 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 352 | 6 | 1 | 6 | 1.5 | COc1ccc(C[C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349566 | 189431 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | ||
| CHEMBL4788831 | 189431 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 372 | 5 | 1 | 6 | 2.3 | COc1ccc([C@H](C)NC(=O)Cn2nnc3c(Cl)cccc3c2=O)cc1 | nan | ||
| 164621186 | 192873 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 323 | 4 | 0 | 6 | 2.4 | Cc1ccc([C@H](C)OC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4871591 | 192873 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 323 | 4 | 0 | 6 | 2.4 | Cc1ccc([C@H](C)OC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349767 | 190109 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4797410 | 190109 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349767 | 190109 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | nan | ||
| CHEMBL4797410 | 190109 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 354 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3c(F)cc(C)cc3c2=O)cc1 | nan | ||
| 164620725 | 192864 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.2 | COc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4871506 | 192864 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.2 | COc1ccc([C@H](C)NC(=O)C(C)n2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 121349809 | 189940 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | ||
| CHEMBL4795372 | 189940 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 356 | 5 | 1 | 6 | 1.8 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(F)cc3c2=O)cc1 | nan | ||
| 121349740 | 188870 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | ||
| CHEMBL4781651 | 188870 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 352 | 5 | 1 | 6 | 2.0 | COc1ccc([C@H](C)NC(=O)Cn2nnc3ccc(C)cc3c2=O)cc1 | nan | ||
| 121349795 | 190228 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | ||
| CHEMBL4798933 | 190228 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 336 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nnc3cccc(C)c3c2=O)cc1 | nan | ||
| 121349558 | 188751 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 428 | 5 | 1 | 6 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | ||
| CHEMBL4780121 | 188751 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 428 | 5 | 1 | 6 | 2.8 | C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1F | nan | ||
| 41757362 | 188992 | 1 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| CHEMBL4783081 | 188992 | 1 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | 10.1021/acs.jmedchem.1c00820 | ||
| 41757362 | 188992 | 1 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | ||
| CHEMBL4783081 | 188992 | 1 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 352 | 6 | 1 | 6 | 2.1 | CCOc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1 | nan | ||
| 2144 | 9135 | 0 | None | - | 1 | Human | 3.1 | pKi | = | 3.1 | Binding | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | ||
| 3313 | 9135 | 0 | None | - | 1 | Human | 3.1 | pKi | = | 3.1 | Binding | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | ||
| 6140 | 9135 | 0 | None | - | 1 | Human | 3.1 | pKi | = | 3.1 | Binding | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | ||
| 6925665 | 9135 | 0 | None | - | 1 | Human | 3.1 | pKi | = | 3.1 | Binding | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | ||
| CHEMBL301523 | 9135 | 0 | None | - | 1 | Human | 3.1 | pKi | = | 3.1 | Binding | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | ||
| DB00120 | 9135 | 0 | None | - | 1 | Human | 3.1 | pKi | = | 3.1 | Binding | Guide to Pharmacology | 165 | 3 | 2 | 2 | 0.6 | N[C@H](C(=O)O)Cc1ccccc1 | 26349500 | ||
| 2780 | 9152 | 106 | None | -630 | 2 | Human | 3.1 | pKi | = | 3.1 | Binding | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | ||
| 6305 | 9152 | 106 | None | -630 | 2 | Human | 3.1 | pKi | = | 3.1 | Binding | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | ||
| 6923516 | 9152 | 106 | None | -630 | 2 | Human | 3.1 | pKi | = | 3.1 | Binding | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | ||
| 717 | 9152 | 106 | None | -630 | 2 | Human | 3.1 | pKi | = | 3.1 | Binding | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | ||
| CHEMBL54976 | 9152 | 106 | None | -630 | 2 | Human | 3.1 | pKi | = | 3.1 | Binding | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | ||
| DB00150 | 9152 | 106 | None | -630 | 2 | Human | 3.1 | pKi | = | 3.1 | Binding | Guide to Pharmacology | 204 | 3 | 3 | 2 | 1.1 | OC(=O)[C@H](Cc1c[nH]c2c1cccc2)N | 26349500 | ||
| 11685 | 10911 | 25 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 34260228 | ||
| 121349608 | 10911 | 25 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 34260228 | ||
| CHEMBL4779773 | 10911 | 25 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | 392 | 5 | 1 | 6 | 2.6 | O=c1c2c(nnn1CC(=O)N[C@@H](C)c1ccc(cc1)OC(F)(F)F)cccc2 | 34260228 | ||
| 2548547 | 8930 | 45 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 316 | 5 | 2 | 2 | 2.9 | O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl | 26349500 | ||
| 8766 | 8930 | 45 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 316 | 5 | 2 | 2 | 2.9 | O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl | 26349500 | ||
| CHEMBL3633720 | 8930 | 45 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 316 | 5 | 2 | 2 | 2.9 | O=C(N[C@H](c1ccccc1)C)CNC(=O)c1cccc(c1)Cl | 26349500 | ||