Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 162644596 | 179525 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | ||
| CHEMBL4740228 | 179525 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2cccnn2c1=O | nan | ||
| 153585580 | 179550 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| CHEMBL4740491 | 179550 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| 153585418 | 179553 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 434 | 5 | 1 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4740519 | 179553 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 434 | 5 | 1 | 8 | 1.4 | C[C@H](NC(=O)Cn1nc2cc(N3CCOCC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 148659040 | 179670 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(Br)n3c2=O)cc1 | nan | ||
| CHEMBL4741806 | 179670 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cccc(Br)n3c2=O)cc1 | nan | ||
| 153585598 | 179721 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 446 | 5 | 1 | 7 | 1.9 | C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4742673 | 179721 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 446 | 5 | 1 | 7 | 1.9 | C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 148397968 | 179741 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | ||
| CHEMBL4742901 | 179741 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | ||
| 147048009 | 179763 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(Br)cn3c2=O)cc1 | nan | ||
| CHEMBL4743199 | 179763 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 388 | 4 | 1 | 5 | 2.4 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(Br)cn3c2=O)cc1 | nan | ||
| 147451915 | 179793 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4743612 | 179793 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 152956498 | 179816 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 324 | 4 | 1 | 5 | 2.2 | Cc1ccc([C@H](C)NC(=O)C(C)n2nc3ccccn3c2=O)cc1 | nan | ||
| CHEMBL4743938 | 179816 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 324 | 4 | 1 | 5 | 2.2 | Cc1ccc([C@H](C)NC(=O)C(C)n2nc3ccccn3c2=O)cc1 | nan | ||
| 153585490 | 179847 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ncccn2c1=O | nan | ||
| CHEMBL4744169 | 179847 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2ncccn2c1=O | nan | ||
| 153585688 | 179864 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4744340 | 179864 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 479 | 6 | 2 | 8 | 2.2 | C[C@H](NC(=O)Cn1nc2cc(N3CCC[C@@H](O)C3)ccn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 162647825 | 179941 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | ||
| CHEMBL4745096 | 179941 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 399 | 5 | 1 | 7 | 1.8 | C[C@H](NC(=O)Cn1nc2cccnn2c1=O)c1ccc(OC(F)(F)F)c(F)c1 | nan | ||
| 152005060 | 179968 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 447 | 5 | 1 | 8 | 1.3 | C[C@H](NC(=O)Cn1nc2c(N3CCN(C)CC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4745432 | 179968 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 447 | 5 | 1 | 8 | 1.3 | C[C@H](NC(=O)Cn1nc2c(N3CCN(C)CC3)nccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 150944515 | 179970 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 425 | 5 | 2 | 7 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(NC(=O)OC(C)(C)C)cccn3c2=O)cc1 | nan | ||
| CHEMBL4745487 | 179970 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 425 | 5 | 2 | 7 | 3.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(NC(=O)OC(C)(C)C)cccn3c2=O)cc1 | nan | ||
| 147626442 | 179985 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1cn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2cn1 | nan | ||
| CHEMBL4745668 | 179985 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 395 | 5 | 1 | 7 | 2.0 | Cc1cn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2cn1 | nan | ||
| 150995037 | 180025 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cnccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4746108 | 180025 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2cnccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162648023 | 180081 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 452 | 7 | 2 | 9 | 1.5 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4746822 | 180081 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 452 | 7 | 2 | 9 | 1.5 | C[C@H](NC(=O)Cn1nc2c(NC3COC3)ccnn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585512 | 180134 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 367 | 4 | 1 | 6 | 1.7 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4747431 | 180134 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 367 | 4 | 1 | 6 | 1.7 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162650006 | 180231 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2cccnn2c1=O | nan | ||
| CHEMBL4748681 | 180231 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | 1 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 345 | 4 | 1 | 6 | 1.7 | Cc1cc(Cl)ccc1[C@H](C)NC(=O)Cn1nc2cccnn2c1=O | nan | ||
| 153585452 | 180317 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL4749705 | 180317 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 349 | 4 | 1 | 6 | 1.6 | C[C@H](NC(=O)Cn1nc2ncc(F)cn2c1=O)c1ccc(Cl)cc1 | nan | ||
| 151976938 | 180346 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | ||
| CHEMBL4750143 | 180346 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 310 | 4 | 1 | 5 | 1.7 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccccn3c2=O)cc1 | nan | ||
| 147634500 | 180384 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F | nan | ||
| CHEMBL4750692 | 180384 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | -3 | 2 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ncc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1F | nan | ||
| 149094095 | 180388 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 421 | 6 | 1 | 7 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4750718 | 180388 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 421 | 6 | 1 | 7 | 2.5 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 152023194 | 180436 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(Cl)cccn3c2=O)cc1 | nan | ||
| CHEMBL4751203 | 180436 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3c(Cl)cccn3c2=O)cc1 | nan | ||
| 153585601 | 180443 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 478 | 6 | 1 | 8 | 2.0 | C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4751259 | 180443 | None | 0 | Human | Functional | pEC50 | = | 9 | 9.0 | - | 1 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as increase in calcium flux by calcium 5 dye based FLIPR assay |
ChEMBL | 478 | 6 | 1 | 8 | 2.0 | C[C@H](NC(=O)Cn1nc2cccc(N3CCN(C)CC3)n2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
Showing 1 to 50 of 762 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 153585580 | 179550 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| CHEMBL4740491 | 179550 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 411 | 6 | 1 | 8 | 1.7 | COc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| 148397968 | 179741 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | ||
| CHEMBL4742901 | 179741 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 363 | 4 | 1 | 6 | 1.9 | Cc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2n1 | nan | ||
| 153585666 | 179743 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 378 | 5 | 1 | 6 | 2.2 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | ||
| CHEMBL4742949 | 179743 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 378 | 5 | 1 | 6 | 2.2 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc2c1 | nan | ||
| 147451915 | 179793 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4743612 | 179793 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585625 | 179799 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(C)ccn3c2=O)cc1 | nan | ||
| CHEMBL4743662 | 179799 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 324 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(C)ccn3c2=O)cc1 | nan | ||
| 153585420 | 179916 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 364 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL4744927 | 179916 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 364 | 4 | 1 | 5 | 2.7 | C[C@H](NC(=O)Cn1nc2ccccn2c1=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| 153585722 | 180053 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 394 | 5 | 1 | 6 | 2.6 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| CHEMBL4746401 | 180053 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 394 | 5 | 1 | 6 | 2.6 | Cc1ccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n2c1 | nan | ||
| 162649907 | 180189 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 378 | 5 | 2 | 7 | 1.6 | CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | ||
| CHEMBL4748076 | 180189 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 378 | 5 | 2 | 7 | 1.6 | CNc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | ||
| 152844759 | 180205 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ncc(C3CC3)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4748306 | 180205 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ncc(C3CC3)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585686 | 180359 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | nan | ||
| CHEMBL4750288 | 180359 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1cccc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)n12 | nan | ||
| 147641221 | 180402 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1 | nan | ||
| CHEMBL4750914 | 180402 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 344 | 4 | 1 | 5 | 2.3 | Cc1ccc([C@H](C)NC(=O)Cn2nc3cc(Cl)ccn3c2=O)cc1 | nan | ||
| 153585718 | 180447 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4751304 | 180447 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(C#N)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585581 | 180468 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2ccc(C#N)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4751501 | 180468 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 373 | 4 | 1 | 6 | 2.0 | C[C@H](NC(=O)Cn1nc2ccc(C#N)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585708 | 180563 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL4752808 | 180563 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 348 | 4 | 1 | 5 | 2.2 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)cc1 | nan | ||
| 153585648 | 180623 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 366 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4753388 | 180623 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 366 | 4 | 1 | 5 | 2.3 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162653764 | 180639 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2cc(C3CC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4753640 | 180639 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2cc(C3CC3)cnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585540 | 180714 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 398 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| CHEMBL4754565 | 180714 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 398 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(F)cn2c1=O)c1ccc(OC(F)(F)F)cc1 | nan | ||
| 153585467 | 180715 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 | nan | ||
| CHEMBL4754576 | 180715 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 410 | 6 | 1 | 7 | 2.3 | COc1ccn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)nc2c1 | nan | ||
| 152015494 | 180729 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2c(C3CC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4754735 | 180729 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2c(C3CC3)ccnn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 150352344 | 180877 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4756243 | 180877 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 389 | 5 | 1 | 6 | 2.4 | C[C@H](NC(=O)Cn1nc2ccc(C3CC3)nn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 162655689 | 180889 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | ||
| CHEMBL4756356 | 180889 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 379 | 5 | 1 | 7 | 1.6 | COc1ccnn2c(=O)n(CC(=O)N[C@@H](C)c3ccc(Cl)c(F)c3)nc12 | nan | ||
| 153585712 | 180897 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 419 | 6 | 2 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(NC3COC3)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| CHEMBL4756431 | 180897 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 419 | 6 | 2 | 7 | 2.0 | C[C@H](NC(=O)Cn1nc2cc(NC3COC3)ccn2c1=O)c1ccc(Cl)c(F)c1 | nan | ||
| 153585415 | 180994 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O | nan | ||
| CHEMBL4757506 | 180994 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 363 | 4 | 1 | 6 | 2.1 | CC(C(=O)N[C@@H](C)c1ccc(Cl)c(F)c1)n1nc2ncccn2c1=O | nan | ||
| 153585630 | 181101 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 346 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(F)cn3c2=O)cc1F | nan | ||
| CHEMBL4758841 | 181101 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 346 | 4 | 1 | 5 | 2.0 | Cc1ccc([C@H](C)NC(=O)Cn2nc3ccc(F)cn3c2=O)cc1F | nan | ||
| 153585534 | 181190 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 413 | 5 | 1 | 7 | 2.1 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 | nan | ||
| CHEMBL4759991 | 181190 | None | 0 | Human | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assayAgonist activity at human GPR139 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter assay |
ChEMBL | 413 | 5 | 1 | 7 | 2.1 | Cc1cnc2nn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)c(F)c3)c(=O)n2c1 | nan | ||
Showing 1 to 50 of 556 entries