Ligand source activities (1 row/activity)
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 146293963 | 188237 | 0 | None | - | 1 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 412 | 4 | 1 | 6 | 3.9 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c2)nn1 | nan | ||
| CHEMBL4764444 | 188237 | 0 | None | - | 1 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 412 | 4 | 1 | 6 | 3.9 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c2)nn1 | nan | ||
| 67391041 | 98501 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 479 | 10 | 2 | 9 | 3.3 | CCCCc1c(C(=O)NCc2cncn2CC(=O)O)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409014 | 98501 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 479 | 10 | 2 | 9 | 3.3 | CCCCc1c(C(=O)NCc2cncn2CC(=O)O)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 146294019 | 187144 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 378 | 4 | 1 | 6 | 3.6 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(Cl)c3)c2)nn1 | nan | ||
| CHEMBL4751520 | 187144 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 378 | 4 | 1 | 6 | 3.6 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(Cl)c3)c2)nn1 | nan | ||
| 146293968 | 187519 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 442 | 5 | 1 | 7 | 4.1 | Cc1ccc(C(=O)Nc2cccc(OC(F)(F)F)c2)cc1-n1cc(-c2cncn2C)nn1 | nan | ||
| CHEMBL4755970 | 187519 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 442 | 5 | 1 | 7 | 4.1 | Cc1ccc(C(=O)Nc2cccc(OC(F)(F)F)c2)cc1-n1cc(-c2cncn2C)nn1 | nan | ||
| 146293961 | 187176 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 358 | 4 | 1 | 6 | 3.2 | Cc1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| CHEMBL4751970 | 187176 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 358 | 4 | 1 | 6 | 3.2 | Cc1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| 146293967 | 188279 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 392 | 4 | 1 | 6 | 3.9 | Cc1ccc(C(=O)Nc2cccc(Cl)c2)cc1-n1cc(-c2cncn2C)nn1 | nan | ||
| CHEMBL4764882 | 188279 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 392 | 4 | 1 | 6 | 3.9 | Cc1ccc(C(=O)Nc2cccc(Cl)c2)cc1-n1cc(-c2cncn2C)nn1 | nan | ||
| 146294023 | 186311 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 426 | 4 | 1 | 6 | 4.2 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-n1cc(-c2cncn2C)nn1 | nan | ||
| CHEMBL4741429 | 186311 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 426 | 4 | 1 | 6 | 4.2 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-n1cc(-c2cncn2C)nn1 | nan | ||
| 146293970 | 186766 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 430 | 4 | 1 | 6 | 4.1 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3F)c2)nn1 | nan | ||
| CHEMBL4746958 | 186766 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 430 | 4 | 1 | 6 | 4.1 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3F)c2)nn1 | nan | ||
| 146294020 | 189534 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 428 | 5 | 1 | 7 | 3.8 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)F)c3)c2)nn1 | nan | ||
| CHEMBL4790120 | 189534 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 428 | 5 | 1 | 7 | 3.8 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)F)c3)c2)nn1 | nan | ||
| 146293969 | 187930 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 426 | 4 | 1 | 6 | 4.2 | Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c2)nn1 | nan | ||
| CHEMBL4760780 | 187930 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 426 | 4 | 1 | 6 | 4.2 | Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c2)nn1 | nan | ||
| 146294026 | 186316 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 460 | 7 | 1 | 7 | 4.2 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)C(F)F)c3)c2)nn1 | nan | ||
| CHEMBL4741522 | 186316 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 460 | 7 | 1 | 7 | 4.2 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)C(F)F)c3)c2)nn1 | nan | ||
| 146294021 | 189170 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 442 | 5 | 1 | 7 | 4.1 | Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)F)c3)c2)nn1 | nan | ||
| CHEMBL4785317 | 189170 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 442 | 5 | 1 | 7 | 4.1 | Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(OC(F)(F)F)c3)c2)nn1 | nan | ||
| 146293959 | 186523 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 402 | 5 | 1 | 8 | 2.7 | COC(=O)c1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| CHEMBL4744201 | 186523 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 402 | 5 | 1 | 8 | 2.7 | COC(=O)c1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| 153044177 | 190255 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 369 | 4 | 1 | 7 | 2.8 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C#N)c3)c2)nn1 | nan | ||
| CHEMBL4799308 | 190255 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 369 | 4 | 1 | 7 | 2.8 | Cn1cncc1-c1cn(-c2cccc(C(=O)Nc3cccc(C#N)c3)c2)nn1 | nan | ||
| 153387722 | 190121 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 387 | 5 | 1 | 7 | 3.0 | CN(C)c1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| CHEMBL4797569 | 190121 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 387 | 5 | 1 | 7 | 3.0 | CN(C)c1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| 161475867 | 189645 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 374 | 5 | 1 | 7 | 2.9 | COc1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| CHEMBL4791730 | 189645 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 374 | 5 | 1 | 7 | 2.9 | COc1cccc(NC(=O)c2cccc(-n3cc(-c4cncn4C)nn3)c2)c1 | nan | ||
| 146294022 | 188211 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 392 | 4 | 1 | 6 | 3.9 | Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(Cl)c3)c2)nn1 | nan | ||
| CHEMBL4764060 | 188211 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 392 | 4 | 1 | 6 | 3.9 | Cc1ncn(C)c1-c1cn(-c2cccc(C(=O)Nc3cccc(Cl)c3)c2)nn1 | nan | ||
| 72165163 | 98496 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 435 | 8 | 1 | 8 | 3.7 | CCCCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409009 | 98496 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 435 | 8 | 1 | 8 | 3.7 | CCCCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 72165165 | 98498 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 449 | 8 | 1 | 8 | 4.0 | CCCCc1c(C(=O)NCc2c(C)ncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409011 | 98498 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 449 | 8 | 1 | 8 | 4.0 | CCCCc1c(C(=O)NCc2c(C)ncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 67390737 | 98504 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 437 | 8 | 1 | 9 | 2.9 | CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409019 | 98504 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 437 | 8 | 1 | 9 | 2.9 | CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 46853632 | 88703 | 0 | None | 29 | 2 | Mouse | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 451 | 8 | 3 | 5 | 3.7 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC1(c2ccccn2)CC1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164850 | 88703 | 0 | None | 29 | 2 | Mouse | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 451 | 8 | 3 | 5 | 3.7 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC1(c2ccccn2)CC1 | 10.1016/j.bmcl.2012.08.015 | ||
| 60207828 | 98500 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 475 | 7 | 1 | 8 | 4.6 | CCCCc1c(C(=O)NC2CCCc3ncn(C)c32)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409013 | 98500 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 475 | 7 | 1 | 8 | 4.6 | CCCCc1c(C(=O)NC2CCCc3ncn(C)c32)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 70697110 | 83638 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 4.6 | COc1ccc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069576 | 83638 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 4.6 | COc1ccc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 72163408 | 98511 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 404 | 6 | 1 | 7 | 3.6 | CCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409025 | 98511 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 404 | 6 | 1 | 7 | 3.6 | CCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 72163554 | 98514 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 446 | 9 | 1 | 7 | 4.8 | CCCCCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409028 | 98514 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 446 | 9 | 1 | 7 | 4.8 | CCCCCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 135219010 | 183836 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 476 | 4 | 1 | 7 | 3.2 | CN(C(=O)c1cccc(C(F)(F)F)c1)[C@@H]1CCO[C@H](c2nnc(-c3cnc4n3CCOC4)[nH]2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4632719 | 183836 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 476 | 4 | 1 | 7 | 3.2 | CN(C(=O)c1cccc(C(F)(F)F)c1)[C@@H]1CCO[C@H](c2nnc(-c3cnc4n3CCOC4)[nH]2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| 118319570 | 184101 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 438 | 6 | 1 | 4 | 4.4 | Cc1ncn(CC(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(Cl)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4637087 | 184101 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 438 | 6 | 1 | 4 | 4.4 | Cc1ncn(CC(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(Cl)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| 72945362 | 99153 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1ncc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2431058 | 99153 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1ncc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 71451566 | 88697 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 3.4 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCCC1CCOCC1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164844 | 88697 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 3.4 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCCC1CCOCC1 | 10.1016/j.bmcl.2012.08.015 | ||
| 72945363 | 99154 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1nc(-c2ccncc2)cs1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2431059 | 99154 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1nc(-c2ccncc2)cs1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 141753906 | 184866 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 446 | 4 | 1 | 5 | 4.3 | Cc1ncn(C)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)C2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4647745 | 184866 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 446 | 4 | 1 | 5 | 4.3 | Cc1ncn(C)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)C2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| 71458766 | 88690 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 414 | 8 | 4 | 5 | 2.5 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1c[nH]cn1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164837 | 88690 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 414 | 8 | 4 | 5 | 2.5 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1c[nH]cn1 | 10.1016/j.bmcl.2012.08.015 | ||
| 69643233 | 83641 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 458 | 9 | 3 | 6 | 4.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069579 | 83641 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 458 | 9 | 3 | 6 | 4.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 | 10.1016/j.bmcl.2012.07.063 | ||
| 156017251 | 184413 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 506 | 6 | 1 | 5 | 4.9 | Cc1ncn(CC(F)(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(OC(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4641254 | 184413 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 506 | 6 | 1 | 5 | 4.9 | Cc1ncn(CC(F)(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(OC(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| 72945363 | 99154 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1nc(-c2ccncc2)cs1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2431059 | 99154 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1nc(-c2ccncc2)cs1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 72163555 | 98515 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 432 | 7 | 1 | 7 | 4.5 | CCC(C)c1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409029 | 98515 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 432 | 7 | 1 | 7 | 4.5 | CCC(C)c1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 72945365 | 99156 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 464 | 9 | 3 | 7 | 4.3 | O=C(O)c1cc(-c2ccncc2)sc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2431061 | 99156 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 464 | 9 | 3 | 7 | 4.3 | O=C(O)c1cc(-c2ccncc2)sc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 72945365 | 99156 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 464 | 9 | 3 | 7 | 4.3 | O=C(O)c1cc(-c2ccncc2)sc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2431061 | 99156 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 464 | 9 | 3 | 7 | 4.3 | O=C(O)c1cc(-c2ccncc2)sc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 70693004 | 83611 | 0 | None | - | 1 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 334 | 5 | 3 | 4 | 1.9 | N[C@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069483 | 83611 | 0 | None | - | 1 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 334 | 5 | 3 | 4 | 1.9 | N[C@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O | 10.1016/j.bmcl.2012.07.063 | ||
| 118319577 | 184911 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 450 | 5 | 1 | 4 | 5.1 | Cc1ncn(C(C)C)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4648456 | 184911 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 450 | 5 | 1 | 4 | 5.1 | Cc1ncn(C(C)C)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| 71449754 | 88694 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 439 | 9 | 3 | 5 | 3.2 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCCc1ccccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164841 | 88694 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 439 | 9 | 3 | 5 | 3.2 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCCc1ccccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| 135218928 | 184756 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 488 | 6 | 1 | 6 | 4.4 | Cc1ncn(CC2CC2)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4646017 | 184756 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 488 | 6 | 1 | 6 | 4.4 | Cc1ncn(CC2CC2)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| 134194659 | 184852 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 412 | 4 | 1 | 5 | 4.0 | Cc1ncn(C)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(Cl)c3)C2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4647456 | 184852 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 412 | 4 | 1 | 5 | 4.0 | Cc1ncn(C)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(Cl)c3)C2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| 67389603 | 98509 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 424 | 8 | 1 | 9 | 1.8 | CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(N2CCCC2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409023 | 98509 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 424 | 8 | 1 | 9 | 1.8 | CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(N2CCCC2)n1 | 10.1021/ml400186z | ||
| 134194659 | 184852 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 412 | 4 | 1 | 5 | 4.0 | Cc1ncn(C)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(Cl)c3)C2)[nH]1 | nan | ||
| CHEMBL4647456 | 184852 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 412 | 4 | 1 | 5 | 4.0 | Cc1ncn(C)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(Cl)c3)C2)[nH]1 | nan | ||
| 67497640 | 83610 | 0 | None | 3 | 2 | Mouse | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 334 | 5 | 3 | 4 | 1.9 | N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069482 | 83610 | 0 | None | 3 | 2 | Mouse | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 334 | 5 | 3 | 4 | 1.9 | N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O | 10.1016/j.bmcl.2012.07.063 | ||
| 156013775 | 184053 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 491 | 6 | 1 | 5 | 4.0 | Cc1ncn(CC2CN(C)C2)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4636254 | 184053 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 491 | 6 | 1 | 5 | 4.0 | Cc1ncn(CC2CN(C)C2)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| 42171034 | 98510 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 420 | 7 | 1 | 8 | 3.2 | COCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409024 | 98510 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 420 | 7 | 1 | 8 | 3.2 | COCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 72165164 | 98497 | 0 | None | - | 1 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 421 | 7 | 1 | 8 | 3.3 | CCCc1c(C(=O)NCc2cn(C)cn2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409010 | 98497 | 0 | None | - | 1 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 421 | 7 | 1 | 8 | 3.3 | CCCc1c(C(=O)NCc2cn(C)cn2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 135218927 | 184118 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 488 | 5 | 1 | 6 | 4.7 | Cc1ncn(C2CCC2)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4637374 | 184118 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 488 | 5 | 1 | 6 | 4.7 | Cc1ncn(C2CCC2)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| 72945361 | 99152 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1cnc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2430988 | 99152 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1cnc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 73346302 | 99150 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 404 | 8 | 3 | 6 | 3.3 | O=C(Nc1cc(-c2ccncc2)n[nH]1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2430985 | 99150 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 404 | 8 | 3 | 6 | 3.3 | O=C(Nc1cc(-c2ccncc2)n[nH]1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 71453407 | 88711 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 425 | 8 | 2 | 9 | 2.7 | Cn1cncc1-c1nnc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)s1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164858 | 88711 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 425 | 8 | 2 | 9 | 2.7 | Cn1cncc1-c1nnc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)s1 | 10.1016/j.bmcl.2012.08.015 | ||
| 67496991 | 83647 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 417 | 8 | 2 | 6 | 3.9 | Cn1cc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)cn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069585 | 83647 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 417 | 8 | 2 | 6 | 3.9 | Cn1cc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)cn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 67495836 | 83648 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 403 | 8 | 3 | 5 | 3.9 | O=C(Nc1cccc(-c2cn[nH]c2)c1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069586 | 83648 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 403 | 8 | 3 | 5 | 3.9 | O=C(Nc1cccc(-c2cn[nH]c2)c1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 73353866 | 99158 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 486 | 9 | 2 | 7 | 4.3 | O=C(Nc1cc(-c2ccncc2)nn1CC(F)(F)F)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2431063 | 99158 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 486 | 9 | 2 | 7 | 4.3 | O=C(Nc1cc(-c2ccncc2)nn1CC(F)(F)F)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 70684555 | 83645 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 417 | 8 | 2 | 6 | 3.9 | Cn1ccc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)n1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069583 | 83645 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 417 | 8 | 2 | 6 | 3.9 | Cn1ccc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)n1 | 10.1016/j.bmcl.2012.07.063 | ||
| 71455108 | 88705 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 471 | 8 | 3 | 6 | 4.0 | Cc1nc(C2(N[C@@H](Cc3ccccc3)C(=O)Nc3cc(-c4ccncc4)c[nH]c3=O)CC2)cs1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164852 | 88705 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 471 | 8 | 3 | 6 | 4.0 | Cc1nc(C2(N[C@@H](Cc3ccccc3)C(=O)Nc3cc(-c4ccncc4)c[nH]c3=O)CC2)cs1 | 10.1016/j.bmcl.2012.08.015 | ||
| 136232856 | 83651 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 420 | 8 | 4 | 6 | 2.6 | O=C(Nc1cc(-c2ccn[nH]2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069589 | 83651 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 420 | 8 | 4 | 6 | 2.6 | O=C(Nc1cc(-c2ccn[nH]2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 72163266 | 98503 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 466 | 8 | 1 | 8 | 5.0 | CCCCc1c(C(=O)NCc2sc(C)nc2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409017 | 98503 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 466 | 8 | 1 | 8 | 5.0 | CCCCc1c(C(=O)NCc2sc(C)nc2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 71455107 | 88695 | 0 | None | - | 1 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 480 | 8 | 3 | 6 | 2.4 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCC1CCS(=O)(=O)CC1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164842 | 88695 | 0 | None | - | 1 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 480 | 8 | 3 | 6 | 2.4 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCC1CCS(=O)(=O)CC1 | 10.1016/j.bmcl.2012.08.015 | ||
| 71456911 | 88691 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 428 | 8 | 3 | 6 | 2.5 | Cn1ccc(CN[C@@H](Cc2ccccc2)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)n1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164838 | 88691 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 428 | 8 | 3 | 6 | 2.5 | Cn1ccc(CN[C@@H](Cc2ccccc2)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)n1 | 10.1016/j.bmcl.2012.08.015 | ||
| 67496521 | 83644 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 429 | 8 | 3 | 6 | 4.1 | Nc1cc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069582 | 83644 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 429 | 8 | 3 | 6 | 4.1 | Nc1cc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 72945163 | 99151 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 405 | 8 | 3 | 7 | 2.7 | O=C(Nc1nnc(-c2ccncc2)[nH]1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2430986 | 99151 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 405 | 8 | 3 | 7 | 2.7 | O=C(Nc1nnc(-c2ccncc2)[nH]1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 60207864 | 7858 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 438 | 8 | 1 | 9 | 2.2 | CCOCc1c(cnn1c1ncc(c(n1)N1CCCCC1)C)C(=O)NCc1cncn1C | 10.1021/ml400186z | ||
| 8791 | 7858 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 438 | 8 | 1 | 9 | 2.2 | CCOCc1c(cnn1c1ncc(c(n1)N1CCCCC1)C)C(=O)NCc1cncn1C | 10.1021/ml400186z | ||
| CHEMBL2409007 | 7858 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 438 | 8 | 1 | 9 | 2.2 | CCOCc1c(cnn1c1ncc(c(n1)N1CCCCC1)C)C(=O)NCc1cncn1C | 10.1021/ml400186z | ||
| 71462292 | 88699 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 439 | 8 | 3 | 5 | 3.7 | C[C@H](N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164846 | 88699 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 439 | 8 | 3 | 5 | 3.7 | C[C@H](N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| 71458765 | 88689 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 429 | 8 | 3 | 6 | 3.1 | Cc1cc(CN[C@@H](Cc2ccccc2)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)no1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164836 | 88689 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 429 | 8 | 3 | 6 | 3.1 | Cc1cc(CN[C@@H](Cc2ccccc2)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)no1 | 10.1016/j.bmcl.2012.08.015 | ||
| 71462291 | 88698 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 431 | 8 | 4 | 5 | 1.9 | O=C1CC[C@H](CN[C@@H](Cc2ccccc2)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)N1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164845 | 88698 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 431 | 8 | 4 | 5 | 1.9 | O=C1CC[C@H](CN[C@@H](Cc2ccccc2)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)N1 | 10.1016/j.bmcl.2012.08.015 | ||
| 70693017 | 83652 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 434 | 8 | 3 | 7 | 2.6 | Cn1cc(-c2c[nH]c(=O)c(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)cn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069590 | 83652 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 434 | 8 | 3 | 7 | 2.6 | Cn1cc(-c2c[nH]c(=O)c(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)cn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 67497024 | 83640 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 4.6 | COc1ccc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc1-c1ccncc1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069578 | 83640 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 4.6 | COc1ccc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc1-c1ccncc1 | 10.1016/j.bmcl.2012.07.063 | ||
| 72163406 | 98507 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 424 | 9 | 2 | 9 | 2.1 | CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(NC2CCC2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409021 | 98507 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 424 | 9 | 2 | 9 | 2.1 | CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(NC2CCC2)n1 | 10.1021/ml400186z | ||
| 72163409 | 98512 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 418 | 7 | 1 | 7 | 4.0 | CCCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409026 | 98512 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 418 | 7 | 1 | 7 | 4.0 | CCCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 70697097 | 83616 | 0 | None | - | 1 | Human | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 364 | 6 | 3 | 5 | 2.0 | COc1ccc(C[C@H](N)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)cc1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069493 | 83616 | 0 | None | - | 1 | Human | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 364 | 6 | 3 | 5 | 2.0 | COc1ccc(C[C@H](N)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)cc1 | 10.1016/j.bmcl.2012.07.063 | ||
| 67497915 | 99144 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 449 | 9 | 4 | 8 | 2.1 | CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCc3c[nH]nn3)n(C)n2)ccn1 | 10.1021/ml4000854 | ||
| CHEMBL2430979 | 99144 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 449 | 9 | 4 | 8 | 2.1 | CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCc3c[nH]nn3)n(C)n2)ccn1 | 10.1021/ml4000854 | ||
| 71458768 | 88706 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 509 | 10 | 3 | 7 | 3.2 | O=C(O)Cn1cc(-c2ccncc2)cc(NC(=O)[C@H](Cc2ccccc2)NC2(c3ccccn3)CC2)c1=O | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164853 | 88706 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 509 | 10 | 3 | 7 | 3.2 | O=C(O)Cn1cc(-c2ccncc2)cc(NC(=O)[C@H](Cc2ccccc2)NC2(c3ccccn3)CC2)c1=O | 10.1016/j.bmcl.2012.08.015 | ||
| 72945162 | 99162 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 405 | 8 | 2 | 7 | 3.5 | O=C(Nc1cc(-c2ccncc2)no1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2431067 | 99162 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 405 | 8 | 2 | 7 | 3.5 | O=C(Nc1cc(-c2ccncc2)no1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 135219005 | 184082 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 414 | 4 | 1 | 6 | 3.2 | Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(Cl)c3)CCO2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4636686 | 184082 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 414 | 4 | 1 | 6 | 3.2 | Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(Cl)c3)CCO2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| 135219005 | 184082 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 414 | 4 | 1 | 6 | 3.2 | Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(Cl)c3)CCO2)[nH]1 | nan | ||
| CHEMBL4636686 | 184082 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 414 | 4 | 1 | 6 | 3.2 | Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(Cl)c3)CCO2)[nH]1 | nan | ||
| 73355394 | 99159 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 430 | 7 | 1 | 7 | 3.1 | O=C([C@H](Cc1ccccc1)NCc1cncs1)N1CCn2nc(-c3ccncc3)cc21 | 10.1021/ml4000854 | ||
| CHEMBL2431064 | 99159 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 430 | 7 | 1 | 7 | 3.1 | O=C([C@H](Cc1ccccc1)NCc1cncs1)N1CCn2nc(-c3ccncc3)cc21 | 10.1021/ml4000854 | ||
| 72163407 | 98508 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 410 | 8 | 1 | 9 | 1.4 | CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(N2CCC2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409022 | 98508 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 410 | 8 | 1 | 9 | 1.4 | CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(N2CCC2)n1 | 10.1021/ml400186z | ||
| 71462293 | 88707 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 522 | 11 | 2 | 7 | 3.7 | CN(C)CCn1cc(-c2ccncc2)cc(NC(=O)[C@H](Cc2ccccc2)NC2(c3ccccn3)CC2)c1=O | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164854 | 88707 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 522 | 11 | 2 | 7 | 3.7 | CN(C)CCn1cc(-c2ccncc2)cc(NC(=O)[C@H](Cc2ccccc2)NC2(c3ccccn3)CC2)c1=O | 10.1016/j.bmcl.2012.08.015 | ||
| 72945364 | 99155 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1csc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2431060 | 99155 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1csc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 67497939 | 83636 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 416 | 8 | 2 | 7 | 3.3 | O=C(Nc1nccc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069574 | 83636 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 416 | 8 | 2 | 7 | 3.3 | O=C(Nc1nccc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 70684556 | 83650 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 445 | 8 | 3 | 6 | 3.5 | Cc1cc(-c2c[nH]c(=O)c(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069588 | 83650 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 445 | 8 | 3 | 6 | 3.5 | Cc1cc(-c2c[nH]c(=O)c(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 135218990 | 183963 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 464 | 5 | 1 | 7 | 3.4 | Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(OC(F)(F)F)c3)CCO2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4634933 | 183963 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 464 | 5 | 1 | 7 | 3.4 | Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(OC(F)(F)F)c3)CCO2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| 156020268 | 184838 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 422 | 4 | 1 | 4 | 4.0 | Cc1ncn(C)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4647315 | 184838 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 422 | 4 | 1 | 4 | 4.0 | Cc1ncn(C)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| 60207843 | 98499 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 449 | 8 | 1 | 8 | 4.0 | CCCCc1c(C(=O)NCc2cnc(C)n2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409012 | 98499 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 449 | 8 | 1 | 8 | 4.0 | CCCCc1c(C(=O)NCc2cnc(C)n2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 72163556 | 98517 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 434 | 8 | 1 | 8 | 3.6 | CCOCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409030 | 98517 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 434 | 8 | 1 | 8 | 3.6 | CCOCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 135218990 | 183963 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 464 | 5 | 1 | 7 | 3.4 | Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(OC(F)(F)F)c3)CCO2)[nH]1 | nan | ||
| CHEMBL4634933 | 183963 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 464 | 5 | 1 | 7 | 3.4 | Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(OC(F)(F)F)c3)CCO2)[nH]1 | nan | ||
| 72165042 | 98519 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 446 | 8 | 0 | 7 | 4.7 | CCCc1c(C(=O)N(CC)Cc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409032 | 98519 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 446 | 8 | 0 | 7 | 4.7 | CCCc1c(C(=O)N(CC)Cc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 72945162 | 99162 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 405 | 8 | 2 | 7 | 3.5 | O=C(Nc1cc(-c2ccncc2)no1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2431067 | 99162 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 405 | 8 | 2 | 7 | 3.5 | O=C(Nc1cc(-c2ccncc2)no1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 134194565 | 184439 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 474 | 4 | 1 | 6 | 4.0 | CN(C(=O)c1cccc(C(F)(F)F)c1)[C@@H]1CCC[C@H](c2nnc(-c3cnc4n3CCOC4)[nH]2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4641575 | 184439 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 474 | 4 | 1 | 6 | 4.0 | CN(C(=O)c1cccc(C(F)(F)F)c1)[C@@H]1CCC[C@H](c2nnc(-c3cnc4n3CCOC4)[nH]2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| 70693016 | 83642 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 337 | 7 | 2 | 4 | 3.5 | O=C(Nc1ccccc1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069580 | 83642 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 337 | 7 | 2 | 4 | 3.5 | O=C(Nc1ccccc1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 135218876 | 184473 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 436 | 4 | 1 | 6 | 3.8 | CN(C(=O)c1cccc(Cl)c1)[C@@H]1CCO[C@H](c2nnc(-c3cnc4ccccn34)[nH]2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4641984 | 184473 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 436 | 4 | 1 | 6 | 3.8 | CN(C(=O)c1cccc(Cl)c1)[C@@H]1CCO[C@H](c2nnc(-c3cnc4ccccn34)[nH]2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| 67496855 | 88708 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 4.4 | COc1ncc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NC1(c2ccccn2)CC1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164855 | 88708 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 465 | 9 | 2 | 6 | 4.4 | COc1ncc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NC1(c2ccccn2)CC1 | 10.1016/j.bmcl.2012.08.015 | ||
| 69641837 | 88710 | 0 | None | -2 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 451 | 9 | 3 | 9 | 3.4 | CNc1cc(-c2nnc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)s2)ccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164857 | 88710 | 0 | None | -2 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 451 | 9 | 3 | 9 | 3.4 | CNc1cc(-c2nnc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)s2)ccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| 67497939 | 83636 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 416 | 8 | 2 | 7 | 3.3 | O=C(Nc1nccc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069574 | 83636 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 416 | 8 | 2 | 7 | 3.3 | O=C(Nc1nccc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 73353862 | 99142 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 447 | 9 | 3 | 8 | 3.3 | CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccccc3)NCc3cncs3)n(C)n2)ccn1 | 10.1021/ml4000854 | ||
| CHEMBL2430977 | 99142 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 447 | 9 | 3 | 8 | 3.3 | CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccccc3)NCc3cncs3)n(C)n2)ccn1 | 10.1021/ml4000854 | ||
| 73349343 | 99157 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 418 | 8 | 2 | 7 | 3.3 | Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2431062 | 99157 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 418 | 8 | 2 | 7 | 3.3 | Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 70693005 | 83612 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 368 | 5 | 3 | 4 | 2.6 | N[C@@H](Cc1ccc(Cl)cc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069489 | 83612 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 368 | 5 | 3 | 4 | 2.6 | N[C@@H](Cc1ccc(Cl)cc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O | 10.1016/j.bmcl.2012.07.063 | ||
| 71462290 | 88696 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 418 | 8 | 3 | 5 | 2.8 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC[C@H]1CCCO1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164843 | 88696 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 418 | 8 | 3 | 5 | 2.8 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC[C@H]1CCCO1 | 10.1016/j.bmcl.2012.08.015 | ||
| 71449755 | 88712 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 428 | 8 | 2 | 9 | 3.5 | O=C(Nc1nnc(-c2cncs2)s1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164859 | 88712 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 428 | 8 | 2 | 9 | 3.5 | O=C(Nc1nnc(-c2cncs2)s1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.08.015 | ||
| 134194625 | 184502 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 496 | 6 | 1 | 5 | 5.1 | Cc1ncn(CC(F)F)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)C2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4642312 | 184502 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 496 | 6 | 1 | 5 | 5.1 | Cc1ncn(CC(F)F)c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)C2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| 67497835 | 99146 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 426 | 9 | 4 | 7 | 1.9 | CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCC(=O)O)n(C)n2)ccn1 | 10.1021/ml4000854 | ||
| CHEMBL2430981 | 99146 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 426 | 9 | 4 | 7 | 1.9 | CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCC(=O)O)n(C)n2)ccn1 | 10.1021/ml4000854 | ||
| 70682465 | 83613 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 352 | 5 | 3 | 4 | 2.1 | N[C@@H](Cc1ccc(F)cc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069490 | 83613 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 352 | 5 | 3 | 4 | 2.1 | N[C@@H](Cc1ccc(F)cc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O | 10.1016/j.bmcl.2012.07.063 | ||
| 135205863 | 183864 | 2 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 448 | 4 | 1 | 6 | 3.5 | Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4633161 | 183864 | 2 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 448 | 4 | 1 | 6 | 3.5 | Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| 135205863 | 183864 | 2 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 448 | 4 | 1 | 6 | 3.5 | Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 | nan | ||
| CHEMBL4633161 | 183864 | 2 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 448 | 4 | 1 | 6 | 3.5 | Cc1ncn(C)c1-c1nnc([C@@H]2C[C@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)CCO2)[nH]1 | nan | ||
| 71451565 | 88693 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 426 | 8 | 3 | 6 | 2.6 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1ncccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164840 | 88693 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 426 | 8 | 3 | 6 | 2.6 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1ncccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| 72945364 | 99155 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1csc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2431060 | 99155 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1csc(-c2ccncc2)n1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 134194661 | 184266 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 446 | 4 | 1 | 5 | 4.3 | Cc1ncc(-c2nnc([C@H]3CCC[C@@H](N(C)C(=O)c4cccc(C(F)(F)F)c4)C3)[nH]2)n1C | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4639333 | 184266 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 446 | 4 | 1 | 5 | 4.3 | Cc1ncc(-c2nnc([C@H]3CCC[C@@H](N(C)C(=O)c4cccc(C(F)(F)F)c4)C3)[nH]2)n1C | 10.1016/j.bmcl.2019.126857 | ||
| 70693006 | 83614 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 359 | 5 | 3 | 5 | 1.8 | N#Cc1ccc(C[C@H](N)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)cc1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069491 | 83614 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 359 | 5 | 3 | 5 | 1.8 | N#Cc1ccc(C[C@H](N)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)cc1 | 10.1016/j.bmcl.2012.07.063 | ||
| 69643233 | 83641 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 458 | 9 | 3 | 6 | 4.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069579 | 83641 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 458 | 9 | 3 | 6 | 4.2 | O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 | 10.1016/j.bmcl.2012.07.063 | ||
| 67497640 | 83610 | 0 | None | -3 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 334 | 5 | 3 | 4 | 1.9 | N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2069482 | 83610 | 0 | None | -3 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 334 | 5 | 3 | 4 | 1.9 | N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O | 10.1016/j.bmcl.2012.08.015 | ||
| 67497640 | 83610 | 0 | None | -3 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 334 | 5 | 3 | 4 | 1.9 | N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069482 | 83610 | 0 | None | -3 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 334 | 5 | 3 | 4 | 1.9 | N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O | 10.1016/j.bmcl.2012.07.063 | ||
| 73353863 | 99143 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 3 | 8 | 3.5 | CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCc3cncs3)n(C)n2)ccn1 | 10.1021/ml4000854 | ||
| CHEMBL2430978 | 99143 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 465 | 9 | 3 | 8 | 3.5 | CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCc3cncs3)n(C)n2)ccn1 | 10.1021/ml4000854 | ||
| 72165041 | 98518 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 446 | 7 | 1 | 7 | 4.7 | CCCc1c(C(=O)NC(C)(C)c2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409031 | 98518 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 446 | 7 | 1 | 7 | 4.7 | CCCc1c(C(=O)NC(C)(C)c2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 70682472 | 83635 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 431 | 8 | 3 | 6 | 3.2 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069573 | 83635 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 431 | 8 | 3 | 6 | 3.2 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 73352401 | 99161 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 431 | 8 | 3 | 6 | 3.2 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2431066 | 99161 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 431 | 8 | 3 | 6 | 3.2 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 156016705 | 184438 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 521 | 7 | 1 | 6 | 3.8 | Cc1ncn(CCN2CCOCC2)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4641543 | 184438 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 521 | 7 | 1 | 6 | 3.8 | Cc1ncn(CCN2CCOCC2)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| 73346305 | 99160 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 462 | 10 | 3 | 8 | 2.8 | O=C(O)Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2431065 | 99160 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 462 | 10 | 3 | 8 | 2.8 | O=C(O)Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 67497264 | 83643 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 428 | 8 | 2 | 5 | 4.9 | Cc1cc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069581 | 83643 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 428 | 8 | 2 | 5 | 4.9 | Cc1cc(-c2cccc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 67496729 | 99148 | 0 | None | -1 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 379 | 8 | 3 | 6 | 1.7 | Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCC(=O)O | 10.1021/ml4000854 | ||
| CHEMBL2430983 | 99148 | 0 | None | -1 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 379 | 8 | 3 | 6 | 1.7 | Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCC(=O)O | 10.1021/ml4000854 | ||
| 118319565 | 184489 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 462 | 6 | 1 | 4 | 4.9 | Cc1ncn(CC2CC2)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4642188 | 184489 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 462 | 6 | 1 | 4 | 4.9 | Cc1ncn(CC2CC2)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| 69642849 | 83639 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 4.6 | COc1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069577 | 83639 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 4.6 | COc1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 | 10.1016/j.bmcl.2012.07.063 | ||
| 135219039 | 184640 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 460 | 4 | 1 | 6 | 3.6 | CN(C(=O)c1cccc(C(F)(F)F)c1)[C@@H]1CCO[C@H](c2nnc(-c3cnc4n3CCC4)[nH]2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4644313 | 184640 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 460 | 4 | 1 | 6 | 3.6 | CN(C(=O)c1cccc(C(F)(F)F)c1)[C@@H]1CCO[C@H](c2nnc(-c3cnc4n3CCC4)[nH]2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| 46853632 | 88703 | 0 | None | -29 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 451 | 8 | 3 | 5 | 3.7 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC1(c2ccccn2)CC1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164850 | 88703 | 0 | None | -29 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 451 | 8 | 3 | 5 | 3.7 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC1(c2ccccn2)CC1 | 10.1016/j.bmcl.2012.08.015 | ||
| 71456912 | 88700 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 439 | 8 | 3 | 5 | 3.7 | C[C@@H](N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164847 | 88700 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 439 | 8 | 3 | 5 | 3.7 | C[C@@H](N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| 156019155 | 184762 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 472 | 6 | 1 | 4 | 4.7 | Cc1ncn(CC(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4646115 | 184762 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 472 | 6 | 1 | 4 | 4.7 | Cc1ncn(CC(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| 69641748 | 83649 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 413 | 8 | 2 | 4 | 5.2 | O=C(Nc1cccc(-c2ccccc2)c1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069587 | 83649 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 413 | 8 | 2 | 4 | 5.2 | O=C(Nc1cccc(-c2ccccc2)c1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 70686694 | 83615 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 348 | 5 | 3 | 4 | 2.3 | Cc1ccc(C[C@H](N)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)cc1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069492 | 83615 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 348 | 5 | 3 | 4 | 2.3 | Cc1ccc(C[C@H](N)C(=O)Nc2cc(-c3ccncc3)c[nH]c2=O)cc1 | 10.1016/j.bmcl.2012.07.063 | ||
| 67497044 | 83637 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 414 | 8 | 2 | 5 | 4.5 | O=C(Nc1cccc(-c2ccncc2)c1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069575 | 83637 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 414 | 8 | 2 | 5 | 4.5 | O=C(Nc1cccc(-c2ccncc2)c1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 67496810 | 83646 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 403 | 8 | 3 | 5 | 3.9 | O=C(Nc1cccc(-c2ccn[nH]2)c1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069584 | 83646 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 403 | 8 | 3 | 5 | 3.9 | O=C(Nc1cccc(-c2ccn[nH]2)c1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 70684556 | 83650 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 445 | 8 | 3 | 6 | 3.5 | Cc1cc(-c2c[nH]c(=O)c(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069588 | 83650 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 445 | 8 | 3 | 6 | 3.5 | Cc1cc(-c2c[nH]c(=O)c(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)c2)ccn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 60207837 | 98513 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 432 | 8 | 1 | 7 | 4.4 | CCCCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409027 | 98513 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 432 | 8 | 1 | 7 | 4.4 | CCCCc1c(C(=O)NCc2ccncc2)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 67497965 | 99145 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 450 | 9 | 4 | 9 | 1.5 | CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCc3nn[nH]n3)n(C)n2)ccn1 | 10.1021/ml4000854 | ||
| CHEMBL2430980 | 99145 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 450 | 9 | 4 | 9 | 1.5 | CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCc3nn[nH]n3)n(C)n2)ccn1 | 10.1021/ml4000854 | ||
| 118319567 | 184676 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 438 | 5 | 1 | 5 | 3.9 | Cc1ncn(C)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(OC(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4644869 | 184676 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 438 | 5 | 1 | 5 | 3.9 | Cc1ncn(C)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(OC(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| 71458767 | 88701 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 453 | 9 | 3 | 5 | 4.1 | CCC(N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164848 | 88701 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 453 | 9 | 3 | 5 | 4.1 | CCC(N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| 72945362 | 99153 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1ncc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2431058 | 99153 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1ncc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 137285183 | 184619 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 432 | 4 | 2 | 4 | 4.3 | Cc1nc[nH]c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)C2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4644081 | 184619 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 432 | 4 | 2 | 4 | 4.3 | Cc1nc[nH]c1-c1nnc([C@H]2CCC[C@@H](N(C)C(=O)c3cccc(C(F)(F)F)c3)C2)[nH]1 | 10.1016/j.bmcl.2019.126857 | ||
| 70695053 | 83617 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 388 | 8 | 3 | 4 | 3.0 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCC1CC1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069496 | 83617 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 388 | 8 | 3 | 4 | 3.0 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCC1CC1 | 10.1016/j.bmcl.2012.07.063 | ||
| 73349339 | 99147 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 425 | 9 | 4 | 7 | 1.3 | CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCC(N)=O)n(C)n2)ccn1 | 10.1021/ml4000854 | ||
| CHEMBL2430982 | 99147 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 425 | 9 | 4 | 7 | 1.3 | CNc1cc(-c2cc(NC(=O)[C@H](Cc3ccc(F)cc3)NCC(N)=O)n(C)n2)ccn1 | 10.1021/ml4000854 | ||
| 70695055 | 83619 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 438 | 9 | 3 | 4 | 3.8 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCCc1ccccc1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069498 | 83619 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 438 | 9 | 3 | 4 | 3.8 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCCc1ccccc1 | 10.1016/j.bmcl.2012.07.063 | ||
| 118319569 | 184955 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 490 | 5 | 1 | 4 | 5.0 | Cc1ncn(CC(F)(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4649204 | 184955 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 490 | 5 | 1 | 4 | 5.0 | Cc1ncn(CC(F)(F)F)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| 69642849 | 83639 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 4.6 | COc1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069577 | 83639 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 4.6 | COc1cc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc(-c2ccncc2)c1 | 10.1016/j.bmcl.2012.07.063 | ||
| 70695054 | 83618 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 424 | 8 | 3 | 4 | 3.8 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1ccccc1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069497 | 83618 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 424 | 8 | 3 | 4 | 3.8 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1ccccc1 | 10.1016/j.bmcl.2012.07.063 | ||
| 67497439 | 88709 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 422 | 8 | 2 | 8 | 3.4 | O=C(Nc1nnc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164856 | 88709 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 422 | 8 | 2 | 8 | 3.4 | O=C(Nc1nnc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.08.015 | ||
| 70697110 | 83638 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 4.6 | COc1ccc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069576 | 83638 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 4.6 | COc1ccc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 72945361 | 99152 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1cnc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2430988 | 99152 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 421 | 8 | 2 | 7 | 4.0 | O=C(Nc1cnc(-c2ccncc2)s1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 73352401 | 99161 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 431 | 8 | 3 | 6 | 3.2 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2431066 | 99161 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 431 | 8 | 3 | 6 | 3.2 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 72163264 | 98502 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 435 | 8 | 1 | 8 | 3.7 | CCCCc1c(C(=O)NCc2ccnn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| CHEMBL2409015 | 98502 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 435 | 8 | 1 | 8 | 3.7 | CCCCc1c(C(=O)NCc2ccnn2C)cnn1-c1ncc(C)c(-c2cccs2)n1 | 10.1021/ml400186z | ||
| 70682472 | 83635 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 431 | 8 | 3 | 6 | 3.2 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069573 | 83635 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 431 | 8 | 3 | 6 | 3.2 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 118319555 | 183880 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 447 | 5 | 1 | 5 | 4.0 | Cc1ncn(CC#N)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| CHEMBL4633342 | 183880 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 447 | 5 | 1 | 5 | 4.0 | Cc1ncn(CC#N)c1NC(=O)[C@H]1CCC[C@@H](N(C)C(=O)c2cccc(C(F)(F)F)c2)C1 | 10.1016/j.bmcl.2019.126857 | ||
| 70682472 | 83635 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 431 | 8 | 3 | 6 | 3.2 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2069573 | 83635 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 431 | 8 | 3 | 6 | 3.2 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.08.015 | ||
| 71460580 | 88702 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5.0 | Functional | ChEMBL | 453 | 8 | 3 | 5 | 3.9 | CC(C)(N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164849 | 88702 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5.0 | Functional | ChEMBL | 453 | 8 | 3 | 5 | 3.9 | CC(C)(N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)c[nH]c1=O)c1ccccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| 71460579 | 88692 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 425 | 8 | 3 | 5 | 3.2 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1ccccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164839 | 88692 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 425 | 8 | 3 | 5 | 3.2 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NCc1ccccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| 67497930 | 99149 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 407 | 9 | 2 | 7 | 2.2 | CCOC(=O)CN[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)nn1C | 10.1021/ml4000854 | ||
| CHEMBL2430984 | 99149 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 407 | 9 | 2 | 7 | 2.2 | CCOC(=O)CN[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2ccncc2)nn1C | 10.1021/ml4000854 | ||
| 73346302 | 99150 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 404 | 8 | 3 | 6 | 3.3 | O=C(Nc1cc(-c2ccncc2)n[nH]1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| CHEMBL2430985 | 99150 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 404 | 8 | 3 | 6 | 3.3 | O=C(Nc1cc(-c2ccncc2)n[nH]1)[C@H](Cc1ccccc1)NCc1cncs1 | 10.1021/ml4000854 | ||
| 72163268 | 98506 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 399 | 9 | 1 | 9 | 1.6 | CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(OCC)n1 | 10.1021/ml400186z | ||
| CHEMBL2409020 | 98506 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 399 | 9 | 1 | 9 | 1.6 | CCOCc1c(C(=O)NCc2cncn2C)cnn1-c1ncc(C)c(OCC)n1 | 10.1021/ml400186z | ||
| 67497044 | 83637 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 414 | 8 | 2 | 5 | 4.5 | O=C(Nc1cccc(-c2ccncc2)c1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069575 | 83637 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 414 | 8 | 2 | 5 | 4.5 | O=C(Nc1cccc(-c2ccncc2)c1)[C@H](Cc1ccccc1)NCc1cscn1 | 10.1016/j.bmcl.2012.07.063 | ||
| 67497024 | 83640 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 4.6 | COc1ccc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc1-c1ccncc1 | 10.1016/j.bmcl.2012.07.063 | ||
| CHEMBL2069578 | 83640 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 4.6 | COc1ccc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)cc1-c1ccncc1 | 10.1016/j.bmcl.2012.07.063 | ||
| 71453406 | 88704 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 452 | 8 | 3 | 6 | 3.1 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC1(c2ncccn2)CC1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164851 | 88704 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 452 | 8 | 3 | 6 | 3.1 | O=C(Nc1cc(-c2ccncc2)c[nH]c1=O)[C@H](Cc1ccccc1)NC1(c2ncccn2)CC1 | 10.1016/j.bmcl.2012.08.015 | ||
| 69641837 | 88710 | 0 | None | 2 | 2 | Mouse | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 451 | 9 | 3 | 9 | 3.4 | CNc1cc(-c2nnc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)s2)ccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| CHEMBL2164857 | 88710 | 0 | None | 2 | 2 | Mouse | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 451 | 9 | 3 | 9 | 3.4 | CNc1cc(-c2nnc(NC(=O)[C@H](Cc3ccccc3)NCc3cscn3)s2)ccn1 | 10.1016/j.bmcl.2012.08.015 | ||
| 60207864 | 7858 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 438 | 8 | 1 | 9 | 2.2 | CCOCc1c(cnn1c1ncc(c(n1)N1CCCCC1)C)C(=O)NCc1cncn1C | 24900747 | ||
| 8791 | 7858 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 438 | 8 | 1 | 9 | 2.2 | CCOCc1c(cnn1c1ncc(c(n1)N1CCCCC1)C)C(=O)NCc1cncn1C | 24900747 | ||
| CHEMBL2409007 | 7858 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 438 | 8 | 1 | 9 | 2.2 | CCOCc1c(cnn1c1ncc(c(n1)N1CCCCC1)C)C(=O)NCc1cncn1C | 24900747 | ||
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 59472644 | 80314 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL2017410 | 80314 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134131626 | 151984 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 416 | 6 | 1 | 7 | 3.7 | COc1cc(-c2cn(CC(=O)Nc3cccc(C)c3C)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3912504 | 151984 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 416 | 6 | 1 | 7 | 3.7 | COc1cc(-c2cn(CC(=O)Nc3cccc(C)c3C)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134135453 | 151155 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3905835 | 151155 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134149858 | 158905 | 0 | None | - | 0 | Mouse | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3967871 | 158905 | 0 | None | - | 0 | Mouse | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134149858 | 158905 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3967871 | 158905 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134152061 | 159917 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3976574 | 159917 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| 134152061 | 159917 | 0 | None | - | 0 | Mouse | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3976574 | 159917 | 0 | None | - | 0 | Mouse | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| 134133574 | 150039 | 0 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3896713 | 150039 | 0 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134149858 | 158905 | 0 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3967871 | 158905 | 0 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134132872 | 151481 | 0 | None | - | 0 | Mouse | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 456 | 6 | 1 | 7 | 4.4 | COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3908606 | 151481 | 0 | None | - | 0 | Mouse | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 456 | 6 | 1 | 7 | 4.4 | COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134151189 | 158626 | 0 | None | - | 0 | Mouse | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 427 | 5 | 1 | 7 | 3.8 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3965469 | 158626 | 0 | None | - | 0 | Mouse | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 427 | 5 | 1 | 7 | 3.8 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 59472644 | 80314 | 0 | None | - | 0 | Mouse | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL2017410 | 80314 | 0 | None | - | 0 | Mouse | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134151189 | 158626 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 427 | 5 | 1 | 7 | 3.8 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3965469 | 158626 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 427 | 5 | 1 | 7 | 3.8 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134151189 | 158626 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 427 | 5 | 1 | 7 | 3.8 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3965469 | 158626 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 427 | 5 | 1 | 7 | 3.8 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134135453 | 151155 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3905835 | 151155 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| 59472644 | 80314 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL2017410 | 80314 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134152061 | 159917 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3976574 | 159917 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| 134135453 | 151155 | 0 | None | - | 0 | Mouse | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3905835 | 151155 | 0 | None | - | 0 | Mouse | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134135453 | 151155 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3905835 | 151155 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134152061 | 159917 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3976574 | 159917 | 0 | None | - | 0 | Mouse | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 412 | 5 | 1 | 6 | 4.1 | O=C(Cn1cc(-c2ccc(-n3ccnc3)cc2)nn1)Nc1cccc(Cl)c1Cl | 10.1021/acsmedchemlett.6b00314 | ||
| 67496729 | 99148 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 379 | 8 | 3 | 6 | 1.7 | Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCC(=O)O | 10.1021/ml4000854 | ||
| CHEMBL2430983 | 99148 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 379 | 8 | 3 | 6 | 1.7 | Cn1nc(-c2ccncc2)cc1NC(=O)[C@H](Cc1ccccc1)NCC(=O)O | 10.1021/ml4000854 | ||
| 134135307 | 150871 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3903475 | 150871 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134149858 | 158905 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3967871 | 158905 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 4.4 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134132872 | 151481 | 0 | None | - | 0 | Mouse | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 456 | 6 | 1 | 7 | 4.4 | COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3908606 | 151481 | 0 | None | - | 0 | Mouse | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 456 | 6 | 1 | 7 | 4.4 | COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 59472644 | 80314 | 0 | None | - | 0 | Mouse | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL2017410 | 80314 | 0 | None | - | 0 | Mouse | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 438 | 6 | 1 | 7 | 4.2 | COc1cc(-c2cn(CC(=O)Nc3cccc4ccccc34)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134135307 | 150871 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3903475 | 150871 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134132872 | 151481 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 456 | 6 | 1 | 7 | 4.4 | COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3908606 | 151481 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 456 | 6 | 1 | 7 | 4.4 | COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134137001 | 149926 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 440 | 5 | 0 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)N(C)c3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3895853 | 149926 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 440 | 5 | 0 | 6 | 4.4 | Cc1nccn1-c1ccc(-c2cn(CC(=O)N(C)c3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134133761 | 150056 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 440 | 6 | 1 | 6 | 4.4 | Cc1nccn1Cc1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3896896 | 150056 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 440 | 6 | 1 | 6 | 4.4 | Cc1nccn1Cc1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134145437 | 155539 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 424 | 6 | 1 | 7 | 3.4 | COc1cc(-c2cn(CC(=O)Nc3cccc(F)c3F)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3940492 | 155539 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 424 | 6 | 1 | 7 | 3.4 | COc1cc(-c2cn(CC(=O)Nc3cccc(F)c3F)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134133574 | 150039 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3896713 | 150039 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134131626 | 151984 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 416 | 6 | 1 | 7 | 3.7 | COc1cc(-c2cn(CC(=O)Nc3cccc(C)c3C)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3912504 | 151984 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 416 | 6 | 1 | 7 | 3.7 | COc1cc(-c2cn(CC(=O)Nc3cccc(C)c3C)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134133761 | 150056 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 440 | 6 | 1 | 6 | 4.4 | Cc1nccn1Cc1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3896896 | 150056 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 440 | 6 | 1 | 6 | 4.4 | Cc1nccn1Cc1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134133574 | 150039 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3896713 | 150039 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134132872 | 151481 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 456 | 6 | 1 | 7 | 4.4 | COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3908606 | 151481 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 456 | 6 | 1 | 7 | 4.4 | COc1cc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134135307 | 150871 | 0 | None | - | 0 | Mouse | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3903475 | 150871 | 0 | None | - | 0 | Mouse | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134133574 | 150039 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3896713 | 150039 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)c(F)c2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134151189 | 158626 | 0 | None | - | 0 | Mouse | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 427 | 5 | 1 | 7 | 3.8 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3965469 | 158626 | 0 | None | - | 0 | Mouse | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 427 | 5 | 1 | 7 | 3.8 | Cc1nccn1-c1ccc(-c2cn(CC(=O)Nc3cccc(Cl)c3Cl)nn2)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134131626 | 151984 | 0 | None | - | 0 | Mouse | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 416 | 6 | 1 | 7 | 3.7 | COc1cc(-c2cn(CC(=O)Nc3cccc(C)c3C)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3912504 | 151984 | 0 | None | - | 0 | Mouse | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 416 | 6 | 1 | 7 | 3.7 | COc1cc(-c2cn(CC(=O)Nc3cccc(C)c3C)nn2)ccc1-n1cnc(C)c1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134141648 | 153464 | 0 | None | - | 0 | Mouse | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 454 | 5 | 1 | 6 | 5.1 | Cc1nccn1-c1ccc(-c2cn(C(C)(C)C(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3923863 | 153464 | 0 | None | - | 0 | Mouse | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 454 | 5 | 1 | 6 | 5.1 | Cc1nccn1-c1ccc(-c2cn(C(C)(C)C(=O)Nc3cccc(Cl)c3Cl)nn2)cc1 | 10.1021/acsmedchemlett.6b00314 | ||
| 134135307 | 150871 | 0 | None | - | 0 | Mouse | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| CHEMBL3903475 | 150871 | 0 | None | - | 0 | Mouse | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1cn(-c2ccc(-c3cn(CC(=O)Nc4cccc(Cl)c4Cl)nn3)cc2F)cn1 | 10.1021/acsmedchemlett.6b00314 | ||
| 162658516 | 187843 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 404 | 3 | 0 | 6 | 5.2 | Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4ccccc4Cl)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4759692 | 187843 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 404 | 3 | 0 | 6 | 5.2 | Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4ccccc4Cl)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162661586 | 188245 | 0 | None | - | 0 | Mouse | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 397 | 2 | 1 | 2 | 5.6 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4764518 | 188245 | 0 | None | - | 0 | Mouse | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 397 | 2 | 1 | 2 | 5.6 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162667626 | 189337 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 379 | 2 | 1 | 3 | 4.8 | O=C(Nc1cccc(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4787638 | 189337 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 379 | 2 | 1 | 3 | 4.8 | O=C(Nc1cccc(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162664581 | 188988 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 359 | 2 | 1 | 5 | 3.2 | N#Cc1cccc(NC(=O)N2CCOc3ccc(-n4ccnc4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4783052 | 188988 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 359 | 2 | 1 | 5 | 3.2 | N#Cc1cccc(NC(=O)N2CCOc3ccc(-n4ccnc4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162655529 | 187557 | 0 | None | - | 0 | Mouse | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 413 | 2 | 1 | 3 | 5.2 | O=C(Nc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4756319 | 187557 | 0 | None | - | 0 | Mouse | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 413 | 2 | 1 | 3 | 5.2 | O=C(Nc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162669605 | 189563 | 0 | None | - | 0 | Mouse | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 389 | 3 | 1 | 4 | 4.5 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4C)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4790417 | 189563 | 0 | None | - | 0 | Mouse | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 389 | 3 | 1 | 4 | 4.5 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4C)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162647230 | 186525 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 363 | 2 | 1 | 3 | 4.3 | O=C(Nc1ccc(F)cc1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4744210 | 186525 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 363 | 2 | 1 | 3 | 4.3 | O=C(Nc1ccc(F)cc1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162664227 | 188852 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 363 | 2 | 1 | 3 | 4.3 | O=C(Nc1ccccc1F)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4781462 | 188852 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 363 | 2 | 1 | 3 | 4.3 | O=C(Nc1ccccc1F)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162653622 | 187293 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 397 | 2 | 1 | 3 | 5.0 | O=C(Nc1ccc(F)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4753373 | 187293 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 397 | 2 | 1 | 3 | 5.0 | O=C(Nc1ccc(F)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162655128 | 187495 | 0 | None | - | 0 | Mouse | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 413 | 2 | 1 | 3 | 5.5 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4755668 | 187495 | 0 | None | - | 0 | Mouse | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 413 | 2 | 1 | 3 | 5.5 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162655128 | 187495 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 413 | 2 | 1 | 3 | 5.5 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4755668 | 187495 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 413 | 2 | 1 | 3 | 5.5 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162664099 | 188965 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 412 | 2 | 2 | 3 | 5.5 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCNc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4782723 | 188965 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 412 | 2 | 2 | 3 | 5.5 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCNc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162656305 | 187607 | 0 | None | - | 0 | Mouse | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 437 | 4 | 1 | 4 | 6.0 | O=C(Nc1cccc(Oc2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4756931 | 187607 | 0 | None | - | 0 | Mouse | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 437 | 4 | 1 | 4 | 6.0 | O=C(Nc1cccc(Oc2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162653028 | 187161 | 0 | None | - | 0 | Mouse | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 448 | 4 | 0 | 4 | 4.5 | O=S(=O)(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4751751 | 187161 | 0 | None | - | 0 | Mouse | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 448 | 4 | 0 | 4 | 4.5 | O=S(=O)(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162654686 | 187378 | 0 | None | - | 0 | Mouse | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 413 | 2 | 1 | 3 | 5.5 | O=C(Nc1cccc(Cl)c1Cl)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4754434 | 187378 | 0 | None | - | 0 | Mouse | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 413 | 2 | 1 | 3 | 5.5 | O=C(Nc1cccc(Cl)c1Cl)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162655529 | 187557 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 413 | 2 | 1 | 3 | 5.2 | O=C(Nc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4756319 | 187557 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 413 | 2 | 1 | 3 | 5.2 | O=C(Nc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162664099 | 188965 | 0 | None | - | 0 | Mouse | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 412 | 2 | 2 | 3 | 5.5 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCNc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4782723 | 188965 | 0 | None | - | 0 | Mouse | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 412 | 2 | 2 | 3 | 5.5 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCNc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162645506 | 186375 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 376 | 3 | 1 | 5 | 3.6 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncn4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4742190 | 186375 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 376 | 3 | 1 | 5 | 3.6 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncn4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162677474 | 190366 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 397 | 2 | 1 | 3 | 5.0 | O=C(Nc1cccc(Cl)c1F)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4800653 | 190366 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 397 | 2 | 1 | 3 | 5.0 | O=C(Nc1cccc(Cl)c1F)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162667626 | 189337 | 0 | None | - | 0 | Mouse | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 379 | 2 | 1 | 3 | 4.8 | O=C(Nc1cccc(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4787638 | 189337 | 0 | None | - | 0 | Mouse | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 379 | 2 | 1 | 3 | 4.8 | O=C(Nc1cccc(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162663630 | 188820 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 412 | 3 | 0 | 3 | 4.7 | O=C(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4781022 | 188820 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 412 | 3 | 0 | 3 | 4.7 | O=C(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162656305 | 187607 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 437 | 4 | 1 | 4 | 6.0 | O=C(Nc1cccc(Oc2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4756931 | 187607 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 437 | 4 | 1 | 4 | 6.0 | O=C(Nc1cccc(Oc2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162661586 | 188245 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 397 | 2 | 1 | 2 | 5.6 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4764518 | 188245 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 397 | 2 | 1 | 2 | 5.6 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162651006 | 187020 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 405 | 4 | 1 | 5 | 4.2 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4OC)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4750165 | 187020 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 405 | 4 | 1 | 5 | 4.2 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4OC)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162663556 | 188703 | 0 | None | - | 0 | Mouse | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 425 | 3 | 1 | 4 | 5.3 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc5ccccc45)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4779679 | 188703 | 0 | None | - | 0 | Mouse | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 425 | 3 | 1 | 4 | 5.3 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc5ccccc45)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162671374 | 189738 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 363 | 2 | 1 | 3 | 4.3 | O=C(Nc1cccc(F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4792959 | 189738 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 363 | 2 | 1 | 3 | 4.3 | O=C(Nc1cccc(F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162653028 | 187161 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 448 | 4 | 0 | 4 | 4.5 | O=S(=O)(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4751751 | 187161 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 448 | 4 | 0 | 4 | 4.5 | O=S(=O)(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162652305 | 187069 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 375 | 3 | 1 | 4 | 4.2 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4750832 | 187069 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 375 | 3 | 1 | 4 | 4.2 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162645588 | 186270 | 0 | None | - | 0 | Mouse | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 405 | 4 | 1 | 5 | 4.2 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(OC)c4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4741033 | 186270 | 0 | None | - | 0 | Mouse | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 405 | 4 | 1 | 5 | 4.2 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(OC)c4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162655503 | 187475 | 0 | None | - | 0 | Mouse | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 426 | 2 | 1 | 3 | 5.5 | CN1CCN(C(=O)Nc2ccc(Cl)c(Cl)c2)Cc2cc(-c3ccncc3)ccc21 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4755519 | 187475 | 0 | None | - | 0 | Mouse | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 426 | 2 | 1 | 3 | 5.5 | CN1CCN(C(=O)Nc2ccc(Cl)c(Cl)c2)Cc2cc(-c3ccncc3)ccc21 | 10.1016/j.bmcl.2016.04.018 | ||
| 162647230 | 186525 | 0 | None | - | 0 | Mouse | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 363 | 2 | 1 | 3 | 4.3 | O=C(Nc1ccc(F)cc1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4744210 | 186525 | 0 | None | - | 0 | Mouse | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 363 | 2 | 1 | 3 | 4.3 | O=C(Nc1ccc(F)cc1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162645588 | 186270 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 405 | 4 | 1 | 5 | 4.2 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(OC)c4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4741033 | 186270 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 405 | 4 | 1 | 5 | 4.2 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(OC)c4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162676367 | 190122 | 0 | None | - | 0 | Mouse | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 383 | 2 | 1 | 2 | 5.7 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCc2ccc(-c3ccncc3)cc21 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4797579 | 190122 | 0 | None | - | 0 | Mouse | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 383 | 2 | 1 | 2 | 5.7 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCc2ccc(-c3ccncc3)cc21 | 10.1016/j.bmcl.2016.04.018 | ||
| 162652305 | 187069 | 0 | None | - | 0 | Mouse | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 375 | 3 | 1 | 4 | 4.2 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4750832 | 187069 | 0 | None | - | 0 | Mouse | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 375 | 3 | 1 | 4 | 4.2 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162667324 | 189192 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 5.8 | O=C(Nc1cccc(-c2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4785678 | 189192 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 5.8 | O=C(Nc1cccc(-c2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162651111 | 187022 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 403 | 3 | 1 | 6 | 5.1 | Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(Cl)c4)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4750179 | 187022 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 403 | 3 | 1 | 6 | 5.1 | Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(Cl)c4)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162664539 | 188897 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 389 | 3 | 1 | 4 | 4.5 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(C)c4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4782047 | 188897 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 389 | 3 | 1 | 4 | 4.5 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(C)c4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162669605 | 189563 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 389 | 3 | 1 | 4 | 4.5 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4C)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4790417 | 189563 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 389 | 3 | 1 | 4 | 4.5 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4C)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162671374 | 189738 | 0 | None | - | 0 | Mouse | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 363 | 2 | 1 | 3 | 4.3 | O=C(Nc1cccc(F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4792959 | 189738 | 0 | None | - | 0 | Mouse | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 363 | 2 | 1 | 3 | 4.3 | O=C(Nc1cccc(F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162664225 | 188851 | 0 | None | - | 0 | Mouse | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 385 | 2 | 2 | 5 | 3.6 | N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(N)c4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4781458 | 188851 | 0 | None | - | 0 | Mouse | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 385 | 2 | 2 | 5 | 3.6 | N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(N)c4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162676176 | 190231 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 4 | 1 | 7 | 5.4 | Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(OC(F)(F)F)c4)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4798957 | 190231 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 4 | 1 | 7 | 5.4 | Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(OC(F)(F)F)c4)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162646661 | 186298 | 0 | None | - | 0 | Mouse | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 468 | 5 | 1 | 3 | 6.7 | CCCCN1CCN(C(=O)Nc2ccc(Cl)c(Cl)c2)Cc2cc(-c3ccncc3)ccc21 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4741265 | 186298 | 0 | None | - | 0 | Mouse | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 468 | 5 | 1 | 3 | 6.7 | CCCCN1CCN(C(=O)Nc2ccc(Cl)c(Cl)c2)Cc2cc(-c3ccncc3)ccc21 | 10.1016/j.bmcl.2016.04.018 | ||
| 162668693 | 189538 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 423 | 3 | 1 | 6 | 5.2 | FC(F)(F)c1cccc(Nc2nnc3n2CCOc2ccc(-c4ccncc4)cc2-3)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4790150 | 189538 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 423 | 3 | 1 | 6 | 5.2 | FC(F)(F)c1cccc(Nc2nnc3n2CCOc2ccc(-c4ccncc4)cc2-3)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162651006 | 187020 | 0 | None | - | 0 | Mouse | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 405 | 4 | 1 | 5 | 4.2 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4OC)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4750165 | 187020 | 0 | None | - | 0 | Mouse | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 405 | 4 | 1 | 5 | 4.2 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4OC)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162658012 | 187897 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 375 | 3 | 1 | 4 | 4.2 | COc1ccccc1NC(=O)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4760456 | 187897 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 375 | 3 | 1 | 4 | 4.2 | COc1ccccc1NC(=O)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162648562 | 186699 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 3 | 0 | 6 | 5.3 | Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(Cl)c4F)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4746135 | 186699 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 3 | 0 | 6 | 5.3 | Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(Cl)c4F)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162659937 | 187980 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 404 | 3 | 0 | 6 | 5.2 | Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(Cl)c4)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4761139 | 187980 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 404 | 3 | 0 | 6 | 5.2 | Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(Cl)c4)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162677474 | 190366 | 0 | None | - | 0 | Mouse | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 397 | 2 | 1 | 3 | 5.0 | O=C(Nc1cccc(Cl)c1F)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4800653 | 190366 | 0 | None | - | 0 | Mouse | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 397 | 2 | 1 | 3 | 5.0 | O=C(Nc1cccc(Cl)c1F)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162646176 | 186474 | 0 | None | - | 0 | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 411 | 2 | 1 | 2 | 6.0 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCCc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4743675 | 186474 | 0 | None | - | 0 | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 411 | 2 | 1 | 2 | 6.0 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCCc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162648374 | 186578 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 402 | 3 | 0 | 5 | 5.0 | Cc1cc(-c2ccc3c(c2)-c2nnc(Cc4cccc(Cl)c4)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4744842 | 186578 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 402 | 3 | 0 | 5 | 5.0 | Cc1cc(-c2ccc3c(c2)-c2nnc(Cc4cccc(Cl)c4)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162664227 | 188852 | 0 | None | - | 0 | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 363 | 2 | 1 | 3 | 4.3 | O=C(Nc1ccccc1F)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4781462 | 188852 | 0 | None | - | 0 | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 363 | 2 | 1 | 3 | 4.3 | O=C(Nc1ccccc1F)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162663630 | 188820 | 0 | None | - | 0 | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 412 | 3 | 0 | 3 | 4.7 | O=C(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4781022 | 188820 | 0 | None | - | 0 | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 412 | 3 | 0 | 3 | 4.7 | O=C(Cc1cccc(C(F)(F)F)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162653622 | 187293 | 0 | None | - | 0 | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 397 | 2 | 1 | 3 | 5.0 | O=C(Nc1ccc(F)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4753373 | 187293 | 0 | None | - | 0 | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 397 | 2 | 1 | 3 | 5.0 | O=C(Nc1ccc(F)c(Cl)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162667324 | 189192 | 0 | None | - | 0 | Mouse | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 5.8 | O=C(Nc1cccc(-c2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4785678 | 189192 | 0 | None | - | 0 | Mouse | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 421 | 3 | 1 | 3 | 5.8 | O=C(Nc1cccc(-c2ccccc2)c1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162655226 | 187469 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 439 | 4 | 1 | 7 | 5.0 | FC(F)(F)Oc1cccc(Nc2nnc3n2CCOc2ccc(-c4ccncc4)cc2-3)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4755454 | 187469 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 439 | 4 | 1 | 7 | 5.0 | FC(F)(F)Oc1cccc(Nc2nnc3n2CCOc2ccc(-c4ccncc4)cc2-3)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162668988 | 189370 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 437 | 3 | 1 | 6 | 5.5 | Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(C(F)(F)F)c4)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4788072 | 189370 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 437 | 3 | 1 | 6 | 5.5 | Cc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(C(F)(F)F)c4)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162654686 | 187378 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 413 | 2 | 1 | 3 | 5.5 | O=C(Nc1cccc(Cl)c1Cl)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4754434 | 187378 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 413 | 2 | 1 | 3 | 5.5 | O=C(Nc1cccc(Cl)c1Cl)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162653296 | 187229 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 451 | 4 | 1 | 6 | 5.7 | CCc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(C(F)(F)F)c4)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4752684 | 187229 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 451 | 4 | 1 | 6 | 5.7 | CCc1cc(-c2ccc3c(c2)-c2nnc(Nc4cccc(C(F)(F)F)c4)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162653133 | 187149 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 454 | 4 | 0 | 7 | 5.4 | Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(OC(F)(F)F)c4)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4751613 | 187149 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 454 | 4 | 0 | 7 | 5.4 | Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4cccc(OC(F)(F)F)c4)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162660699 | 188146 | 0 | None | - | 0 | Mouse | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 370 | 2 | 1 | 4 | 4.0 | N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4763234 | 188146 | 0 | None | - | 0 | Mouse | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 370 | 2 | 1 | 4 | 4.0 | N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162663561 | 188718 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 345 | 2 | 1 | 3 | 4.2 | O=C(Nc1ccccc1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4779820 | 188718 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 345 | 2 | 1 | 3 | 4.2 | O=C(Nc1ccccc1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162660699 | 188146 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 370 | 2 | 1 | 4 | 4.0 | N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4763234 | 188146 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 370 | 2 | 1 | 4 | 4.0 | N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccncc4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162664225 | 188851 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 385 | 2 | 2 | 5 | 3.6 | N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(N)c4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4781458 | 188851 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 385 | 2 | 2 | 5 | 3.6 | N#Cc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc(N)c4)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162646176 | 186474 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 411 | 2 | 1 | 2 | 6.0 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCCc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4743675 | 186474 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 411 | 2 | 1 | 2 | 6.0 | O=C(Nc1ccc(Cl)c(Cl)c1)N1CCCc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162663561 | 188718 | 0 | None | - | 0 | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 345 | 2 | 1 | 3 | 4.2 | O=C(Nc1ccccc1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4779820 | 188718 | 0 | None | - | 0 | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 345 | 2 | 1 | 3 | 4.2 | O=C(Nc1ccccc1)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162645412 | 186467 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 454 | 4 | 0 | 7 | 5.4 | Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4ccccc4OC(F)(F)F)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4743615 | 186467 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 454 | 4 | 0 | 7 | 5.4 | Cc1cc(-c2ccc3c(c2)-c2nnc(Oc4ccccc4OC(F)(F)F)n2CCO3)ccn1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162658012 | 187897 | 0 | None | - | 0 | Mouse | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 375 | 3 | 1 | 4 | 4.2 | COc1ccccc1NC(=O)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4760456 | 187897 | 0 | None | - | 0 | Mouse | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 375 | 3 | 1 | 4 | 4.2 | COc1ccccc1NC(=O)N1CCOc2ccc(-c3ccncc3)cc2C1 | 10.1016/j.bmcl.2016.04.018 | ||
| 162663556 | 188703 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 425 | 3 | 1 | 4 | 5.3 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc5ccccc45)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||
| CHEMBL4779679 | 188703 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 425 | 3 | 1 | 4 | 5.3 | COc1cccc(NC(=O)N2CCOc3ccc(-c4ccnc5ccccc45)cc3C2)c1 | 10.1016/j.bmcl.2016.04.018 | ||