Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 168293367 | 192188 | None | 0 | Mouse | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayPartial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 644 | 27 | 5 | 8 | 4.9 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](NC(=O)CCCC)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| CHEMBL5202805 | 192188 | None | 0 | Mouse | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayPartial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 644 | 27 | 5 | 8 | 4.9 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](NC(=O)CCCC)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| 168293367 | 192188 | None | 0 | Mouse | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayPartial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 644 | 27 | 5 | 8 | 4.9 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](NC(=O)CCCC)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| CHEMBL5202805 | 192188 | None | 0 | Mouse | Functional | pEC50 | = | 9.2 | 9.2 | - | 1 | Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayPartial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 644 | 27 | 5 | 8 | 4.9 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](NC(=O)CCCC)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| 168287780 | 191932 | None | 0 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayPartial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 559 | 23 | 4 | 7 | 4.9 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@@H](C)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| CHEMBL5198736 | 191932 | None | 0 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayPartial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 559 | 23 | 4 | 7 | 4.9 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@@H](C)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| 168287780 | 191932 | None | 0 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayPartial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 559 | 23 | 4 | 7 | 4.9 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@@H](C)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| CHEMBL5198736 | 191932 | None | 0 | Mouse | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayPartial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 559 | 23 | 4 | 7 | 4.9 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@@H](C)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| 168275621 | 190725 | None | 0 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayPartial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 644 | 24 | 5 | 8 | 4.8 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](NC(=O)C(C)(C)C)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| CHEMBL5180950 | 190725 | None | 0 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayPartial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 644 | 24 | 5 | 8 | 4.8 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](NC(=O)C(C)(C)C)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| 168275621 | 190725 | None | 0 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayPartial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 644 | 24 | 5 | 8 | 4.8 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](NC(=O)C(C)(C)C)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| CHEMBL5180950 | 190725 | None | 0 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayPartial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 644 | 24 | 5 | 8 | 4.8 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](NC(=O)C(C)(C)C)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| 168297615 | 192389 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | Agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayAgonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 560 | 23 | 5 | 8 | 3.6 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| CHEMBL5205892 | 192389 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | Agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayAgonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 560 | 23 | 5 | 8 | 3.6 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| 168297615 | 192389 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | Agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayAgonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 560 | 23 | 5 | 8 | 3.6 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| CHEMBL5205892 | 192389 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | Agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayAgonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 560 | 23 | 5 | 8 | 3.6 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| 6402927 | 185915 | None | 8 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Antagonist activity at human GPR174 by CRAAntagonist activity at human GPR174 by CRA |
ChEMBL | 390 | 4 | 2 | 5 | 4.0 | Cc1ccc(-c2nnc(Nc3ccccc3)c3ccccc23)cc1S(N)(=O)=O | nan | ||
| CHEMBL4867042 | 185915 | None | 8 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Antagonist activity at human GPR174 by CRAAntagonist activity at human GPR174 by CRA |
ChEMBL | 390 | 4 | 2 | 5 | 4.0 | Cc1ccc(-c2nnc(Nc3ccccc3)c3ccccc23)cc1S(N)(=O)=O | nan | ||
| 6402927 | 185915 | None | 8 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Inhibition of GPR174 (unknown origin) in cells assessed as incorporation of nuclear localization sequence into transmembrane protein by cellular redistribution assayInhibition of GPR174 (unknown origin) in cells assessed as incorporation of nuclear localization sequence into transmembrane protein by cellular redistribution assay |
ChEMBL | 390 | 4 | 2 | 5 | 4.0 | Cc1ccc(-c2nnc(Nc3ccccc3)c3ccccc23)cc1S(N)(=O)=O | nan | ||
| CHEMBL4867042 | 185915 | None | 8 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Inhibition of GPR174 (unknown origin) in cells assessed as incorporation of nuclear localization sequence into transmembrane protein by cellular redistribution assayInhibition of GPR174 (unknown origin) in cells assessed as incorporation of nuclear localization sequence into transmembrane protein by cellular redistribution assay |
ChEMBL | 390 | 4 | 2 | 5 | 4.0 | Cc1ccc(-c2nnc(Nc3ccccc3)c3ccccc23)cc1S(N)(=O)=O | nan | ||
| 155088299 | 184552 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 385 | 4 | 1 | 4 | 4.8 | CCCOc1ccc(C2C3=C(CCCC3=O)NC3=C2C(=O)c2ccccc23)cc1 | nan | ||
| CHEMBL4846490 | 184552 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 385 | 4 | 1 | 4 | 4.8 | CCCOc1ccc(C2C3=C(CCCC3=O)NC3=C2C(=O)c2ccccc23)cc1 | nan | ||
| 155088352 | 184797 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 419 | 3 | 1 | 4 | 5.8 | O=C1CCCC2=C1C(c1ccc(Oc3ccccc3)cc1)C1=C(N2)c2ccccc2C1=O | nan | ||
| CHEMBL4850089 | 184797 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 419 | 3 | 1 | 4 | 5.8 | O=C1CCCC2=C1C(c1ccc(Oc3ccccc3)cc1)C1=C(N2)c2ccccc2C1=O | nan | ||
| 155088338 | 184924 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 411 | 3 | 1 | 4 | 5.3 | O=C1CCCC2=C1C(c1ccc(OC3CCCC3)cc1)C1=C(N2)c2ccccc2C1=O | nan | ||
| CHEMBL4851923 | 184924 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 411 | 3 | 1 | 4 | 5.3 | O=C1CCCC2=C1C(c1ccc(OC3CCCC3)cc1)C1=C(N2)c2ccccc2C1=O | nan | ||
| 3748676 | 185326 | None | 5 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 357 | 2 | 1 | 4 | 4.0 | COc1ccc(C2C3=C(CCCC3=O)NC3=C2C(=O)c2ccccc23)cc1 | nan | ||
| CHEMBL4857874 | 185326 | None | 5 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 357 | 2 | 1 | 4 | 4.0 | COc1ccc(C2C3=C(CCCC3=O)NC3=C2C(=O)c2ccccc23)cc1 | nan | ||
| 5302144 | 185751 | None | 7 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 394 | 4 | 0 | 6 | 3.4 | CCOC(=O)N1CCN(c2cc(N3CCCCC3C)c(F)cc2[N+](=O)[O-])CC1 | nan | ||
| CHEMBL4864529 | 185751 | None | 7 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 394 | 4 | 0 | 6 | 3.4 | CCOC(=O)N1CCN(c2cc(N3CCCCC3C)c(F)cc2[N+](=O)[O-])CC1 | nan | ||
| 2885562 | 184502 | None | 6 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 476 | 5 | 0 | 6 | 3.8 | Cc1ccc(S(=O)(=O)N2CCN(c3cc(N4CCC(C)CC4)c(F)cc3[N+](=O)[O-])CC2)cc1 | nan | ||
| CHEMBL4845840 | 184502 | None | 6 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 476 | 5 | 0 | 6 | 3.8 | Cc1ccc(S(=O)(=O)N2CCN(c3cc(N4CCC(C)CC4)c(F)cc3[N+](=O)[O-])CC2)cc1 | nan | ||
| 155088353 | 184647 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 411 | 2 | 1 | 4 | 4.9 | O=C1CCCC2=C1C(c1ccc(OC(F)(F)F)cc1)C1=C(N2)c2ccccc2C1=O | nan | ||
| CHEMBL4847974 | 184647 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 411 | 2 | 1 | 4 | 4.9 | O=C1CCCC2=C1C(c1ccc(OC(F)(F)F)cc1)C1=C(N2)c2ccccc2C1=O | nan | ||
| 155088328 | 184787 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 399 | 5 | 1 | 4 | 5.2 | CCCCOc1ccc(C2C3=C(CCCC3=O)NC3=C2C(=O)c2ccccc23)cc1 | nan | ||
| CHEMBL4849977 | 184787 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 399 | 5 | 1 | 4 | 5.2 | CCCCOc1ccc(C2C3=C(CCCC3=O)NC3=C2C(=O)c2ccccc23)cc1 | nan | ||
| 155088354 | 184866 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 383 | 4 | 1 | 4 | 4.6 | C=CCOc1ccc(C2C3=C(CCCC3=O)NC3=C2C(=O)c2ccccc23)cc1 | nan | ||
| CHEMBL4851035 | 184866 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 383 | 4 | 1 | 4 | 4.6 | C=CCOc1ccc(C2C3=C(CCCC3=O)NC3=C2C(=O)c2ccccc23)cc1 | nan | ||
| 3147417 | 185345 | None | 8 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 369 | 2 | 1 | 3 | 5.1 | CC(C)c1ccc(C2C3=C(CCCC3=O)NC3=C2C(=O)c2ccccc23)cc1 | nan | ||
| CHEMBL4858201 | 185345 | None | 8 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 369 | 2 | 1 | 3 | 5.1 | CC(C)c1ccc(C2C3=C(CCCC3=O)NC3=C2C(=O)c2ccccc23)cc1 | nan | ||
| 155088335 | 185831 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 393 | 3 | 1 | 4 | 4.6 | O=C1CCCC2=C1C(c1ccc(OC(F)F)cc1)C1=C(N2)c2ccccc2C1=O | nan | ||
| CHEMBL4865805 | 185831 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 393 | 3 | 1 | 4 | 4.6 | O=C1CCCC2=C1C(c1ccc(OC(F)F)cc1)C1=C(N2)c2ccccc2C1=O | nan | ||
| 168293524 | 192190 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayAgonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 664 | 25 | 5 | 8 | 5.0 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](NC(=O)c2ccccc2)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| CHEMBL5202832 | 192190 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayAgonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 664 | 25 | 5 | 8 | 5.0 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](NC(=O)c2ccccc2)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| 168293524 | 192190 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayAgonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 664 | 25 | 5 | 8 | 5.0 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](NC(=O)c2ccccc2)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| CHEMBL5202832 | 192190 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assayAgonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay |
ChEMBL | 664 | 25 | 5 | 8 | 5.0 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](NC(=O)c2ccccc2)C(=O)O)c1 | 10.1021/acs.jmedchem.1c00347 | ||
| 155088332 | 186264 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 399 | 2 | 1 | 4 | 5.2 | CC(C)(C)Oc1ccc(C2C3=C(CCCC3=O)NC3=C2C(=O)c2ccccc23)cc1 | nan | ||
| CHEMBL4872392 | 186264 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activityInverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity |
ChEMBL | 399 | 2 | 1 | 4 | 5.2 | CC(C)(C)Oc1ccc(C2C3=C(CCCC3=O)NC3=C2C(=O)c2ccccc23)cc1 | nan | ||
| 2877723 | 185665 | None | 6 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Inhibition of GPR174 (unknown origin) in cells assessed as incorporation of nuclear localization sequence into transmembrane protein by cellular redistribution assayInhibition of GPR174 (unknown origin) in cells assessed as incorporation of nuclear localization sequence into transmembrane protein by cellular redistribution assay |
ChEMBL | 412 | 4 | 0 | 5 | 3.7 | O=C(c1ccccc1)N1CCN(c2cc(N3CCCCC3)c(F)cc2[N+](=O)[O-])CC1 | nan | ||
| CHEMBL4863268 | 185665 | None | 6 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Inhibition of GPR174 (unknown origin) in cells assessed as incorporation of nuclear localization sequence into transmembrane protein by cellular redistribution assayInhibition of GPR174 (unknown origin) in cells assessed as incorporation of nuclear localization sequence into transmembrane protein by cellular redistribution assay |
ChEMBL | 412 | 4 | 0 | 5 | 3.7 | O=C(c1ccccc1)N1CCN(c2cc(N3CCCCC3)c(F)cc2[N+](=O)[O-])CC1 | nan | ||
Showing 1 to 50 of 277 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 6402927 | 185915 | None | 8 | Human | Binding | pEC50 | = | 6 | 6.0 | - | 0 | Allosteric modulator activity at human GPR174 by CRAAllosteric modulator activity at human GPR174 by CRA |
ChEMBL | 390 | 4 | 2 | 5 | 4.0 | Cc1ccc(-c2nnc(Nc3ccccc3)c3ccccc23)cc1S(N)(=O)=O | nan | ||
| CHEMBL4867042 | 185915 | None | 8 | Human | Binding | pEC50 | = | 6 | 6.0 | - | 0 | Allosteric modulator activity at human GPR174 by CRAAllosteric modulator activity at human GPR174 by CRA |
ChEMBL | 390 | 4 | 2 | 5 | 4.0 | Cc1ccc(-c2nnc(Nc3ccccc3)c3ccccc23)cc1S(N)(=O)=O | nan | ||
| 122177510 | 121236 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 511 | 23 | 4 | 8 | 4.3 | CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577164 | 121236 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 511 | 23 | 4 | 8 | 4.3 | CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177506 | 121232 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 537 | 24 | 3 | 9 | 4.6 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)OC | 10.1021/jm5020082 | ||
| CHEMBL3577158 | 121232 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 537 | 24 | 3 | 9 | 4.6 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)OC | 10.1021/jm5020082 | ||
| 122177506 | 121232 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 537 | 24 | 3 | 9 | 4.6 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)OC | 10.1021/jm5020082 | ||
| CHEMBL3577158 | 121232 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 537 | 24 | 3 | 9 | 4.6 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)OC | 10.1021/jm5020082 | ||
| 122177510 | 121236 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 511 | 23 | 4 | 8 | 4.3 | CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577164 | 121236 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 511 | 23 | 4 | 8 | 4.3 | CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177513 | 121238 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 505 | 19 | 4 | 9 | 2.4 | CCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577167 | 121238 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 505 | 19 | 4 | 9 | 2.4 | CCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177513 | 121238 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 505 | 19 | 4 | 9 | 2.4 | CCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577167 | 121238 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 505 | 19 | 4 | 9 | 2.4 | CCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177511 | 121237 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 483 | 21 | 4 | 8 | 3.5 | CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577165 | 121237 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 483 | 21 | 4 | 8 | 3.5 | CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177511 | 121237 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 483 | 21 | 4 | 8 | 3.5 | CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577165 | 121237 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 483 | 21 | 4 | 8 | 3.5 | CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 52926276 | 121222 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 441 | 19 | 4 | 8 | 2.4 | CCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577147 | 121222 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 441 | 19 | 4 | 8 | 2.4 | CCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177518 | 121244 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 561 | 23 | 4 | 9 | 4.0 | CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| CHEMBL3577172 | 121244 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 561 | 23 | 4 | 9 | 4.0 | CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| 122177518 | 121244 | None | 0 | Human | Binding | pEC50 | = | 7.7 | 7.7 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 561 | 23 | 4 | 9 | 4.0 | CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| CHEMBL3577172 | 121244 | None | 0 | Human | Binding | pEC50 | = | 7.7 | 7.7 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 561 | 23 | 4 | 9 | 4.0 | CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| 52926276 | 121222 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 441 | 19 | 4 | 8 | 2.4 | CCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577147 | 121222 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 441 | 19 | 4 | 8 | 2.4 | CCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177490 | 121215 | None | 0 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 523 | 24 | 4 | 8 | 4.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577138 | 121215 | None | 0 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 523 | 24 | 4 | 8 | 4.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177490 | 121215 | None | 0 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 523 | 24 | 4 | 8 | 4.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577138 | 121215 | None | 0 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 523 | 24 | 4 | 8 | 4.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177493 | 121217 | None | 0 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 525 | 24 | 3 | 7 | 5.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577141 | 121217 | None | 0 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 525 | 24 | 3 | 7 | 5.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177493 | 121217 | None | 0 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 525 | 24 | 3 | 7 | 5.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577141 | 121217 | None | 0 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 525 | 24 | 3 | 7 | 5.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177521 | 121247 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 617 | 27 | 4 | 9 | 5.5 | CCCCCCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| CHEMBL3577175 | 121247 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 617 | 27 | 4 | 9 | 5.5 | CCCCCCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| 122177521 | 121247 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 617 | 27 | 4 | 9 | 5.5 | CCCCCCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| CHEMBL3577175 | 121247 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 617 | 27 | 4 | 9 | 5.5 | CCCCCCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| 52926278 | 121219 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 495 | 22 | 4 | 8 | 3.7 | CCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577144 | 121219 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 495 | 22 | 4 | 8 | 3.7 | CCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 52926278 | 121219 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 495 | 22 | 4 | 8 | 3.7 | CCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577144 | 121219 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 495 | 22 | 4 | 8 | 3.7 | CCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177592 | 121259 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 574 | 23 | 5 | 8 | 3.9 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| CHEMBL3577265 | 121259 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 574 | 23 | 5 | 8 | 3.9 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| 122177592 | 121259 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 574 | 23 | 5 | 8 | 3.9 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| CHEMBL3577265 | 121259 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 574 | 23 | 5 | 8 | 3.9 | CCCCCCCCCCCOc1cccc(CCC(=O)NC[C@@H](O)COP(=O)(O)O[C@@H](C)[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| 122177520 | 121246 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 617 | 27 | 4 | 9 | 5.5 | CCCCCCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577174 | 121246 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 617 | 27 | 4 | 9 | 5.5 | CCCCCCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177520 | 121246 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 617 | 27 | 4 | 9 | 5.5 | CCCCCCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577174 | 121246 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assayAgonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 617 | 27 | 4 | 9 | 5.5 | CCCCCCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
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