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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

bovine adrenal medulla peptide 8-22	707	None	24	Human	Binding	pKi	=	-	7.68	-	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/11850634
bovine adrenal medulla peptide 8-22	707	None	24	Human	Binding	EC50	=	50.00	7.30	-	3	Agonist activity at human MrgprX1	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/acs.jmedchem.9b01003
bovine adrenal medulla peptide 8-22	707	None	24	Human	Binding	EC50	=	50.12	7.30	-	3	Agonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1016/j.bmc.2014.09.025
bovine adrenal medulla peptide 8-22	707	None	24	Human	Binding	pKd	=	-	7.99	-	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/11850634
bovine adrenal medulla peptide 8-22	707	None	24	Mouse	Binding	EC50	=	300.00	6.52	-	3	Agonist activity at mouse MRGPRC11	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/acs.jmedchem.9b01003
bovine adrenal medulla peptide 8-22	707	None	24	Mouse	Binding	EC50	=	251.19	6.60	-	3	Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1016/j.bmc.2014.09.025
bovine adrenal medulla peptide 8-22	707	None	24	Rat	Binding	EC50	=	300.00	6.52	-	3	Agonist activity at rat MRGPRC	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/acs.jmedchem.9b01003
bovine adrenal medulla peptide 8-22	707	None	24	Rat	Binding	EC50	=	316.23	6.50	-	3	Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1016/j.bmc.2014.09.025
CHEMBL145103	36926	None	0	Human	Binding	IC50	=	1850.00	5.73	-	3	Binding affinity to recombinant MrgX1 (unknown origin) by chromatography-based technique	ChEMBL	408.2	6	0	3	5.37	N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1	-
CHEMBL1494771	41979	None	7	Human	Binding	EC50	=	14500.00	4.84	-	1	Positive allosteric modulator activity at human MRGPRX1 transfected in HEK293 cells in presence of BAM8-22 by Fulo4AM dye based FLIPR assay	ChEMBL	242.1	2	0	4	3.79	Cc1ccccc1Oc1ncnc2sccc12	https://dx.doi.org/10.1021/acs.jmedchem.1c01709
CHEMBL1762707	61045	None	0	Human	Binding	IC50	=	50.00	7.30	-	1	Antagonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay	ChEMBL	660.2	13	1	9	4.36	O=C(CN1CCN(c2ccnc(NCCc3ccc(Cl)cc3)n2)CC1)N(CCCN1CCOCC1)Cc1c(Cl)cncc1Cl	https://dx.doi.org/10.1016/j.bmc.2014.09.025
CHEMBL179938	63509	None	0	Human	Binding	EC50	=	510.00	6.29	-	1	Agonist activity at human MrgprX1 expressed in HEK293 cells incubated for 2 mins by Fluo4AM dye based FLIPR assay	ChEMBL	361.2	8	3	4	4.17	COc1cc(CNc2ccc(C(=N)N)cc2)ccc1OCc1ccccc1	https://dx.doi.org/10.1021/acs.jmedchem.9b01003
CHEMBL3343987	115209	None	0	Mouse	Binding	EC50	=	7943.28	5.10	-	1	Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay	ChEMBL	318.2	6	6	4	-1.59	N=C(N)N[C@@H]1CN[C@H](C(=O)N[C@@H](Cc2ccccc2)C(N)=O)C1	https://dx.doi.org/10.1016/j.bmc.2014.09.025
CHEMBL3343988	115210	None	0	Mouse	Binding	EC50	=	794.33	6.10	-	2	Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay	ChEMBL	346.2	6	5	4	-0.87	N=C(N)N1CCC(C(N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)CC1	https://dx.doi.org/10.1016/j.bmc.2014.09.025
CHEMBL3343988	115210	None	0	Rat	Binding	EC50	=	3981.07	5.40	-	2	Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay	ChEMBL	346.2	6	5	4	-0.87	N=C(N)N1CCC(C(N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)CC1	https://dx.doi.org/10.1016/j.bmc.2014.09.025
CHEMBL3343990	115211	None	18	Mouse	Binding	EC50	=	501.19	6.30	-	2	Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay	ChEMBL	320.2	9	6	4	-1.21	N=C(N)NCCC[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	https://dx.doi.org/10.1016/j.bmc.2014.09.025
CHEMBL3343990	115211	None	18	Rat	Binding	EC50	=	6309.57	5.20	-	2	Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay	ChEMBL	320.2	9	6	4	-1.21	N=C(N)NCCC[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	https://dx.doi.org/10.1016/j.bmc.2014.09.025
CHEMBL3343991	115212	None	0	Mouse	Binding	EC50	=	501.19	6.30	-	1	Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay	ChEMBL	332.2	7	6	4	-1.34	N=C(N)NC[C@@H]1CN[C@H](C(=O)N[C@@H](Cc2ccccc2)C(N)=O)C1	https://dx.doi.org/10.1016/j.bmc.2014.09.025
CHEMBL3343992	115213	None	0	Mouse	Binding	EC50	=	31622.78	4.50	-	1	Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay	ChEMBL	354.2	7	6	4	0.20	N=C(N)Nc1cccc(C(N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1	https://dx.doi.org/10.1016/j.bmc.2014.09.025
CHEMBL3343992	115213	None	0	Mouse	Binding	EC50	=	31622.78	4.50	-	1	Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay	ChEMBL	354.2	7	6	4	0.20	N=C(N)Nc1cccc(C(N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1	https://dx.doi.org/10.1016/j.bmc.2014.09.025

Showing 1 to 20 of 113 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)