Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 155146067 | 184713 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay |
ChEMBL | 321 | 4 | 1 | 3 | 4.1 | N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1 | nan | ||
| CHEMBL4848977 | 184713 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay |
ChEMBL | 321 | 4 | 1 | 3 | 4.1 | N#Cc1cc(COc2ccc(Cl)cc2Cl)cc(C(=O)O)c1 | nan | ||
| 155154170 | 184854 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay |
ChEMBL | 331 | 4 | 1 | 3 | 4.0 | O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 | nan | ||
| CHEMBL4850889 | 184854 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 uM of bilirubin by HTRF assay |
ChEMBL | 331 | 4 | 1 | 3 | 4.0 | O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)n1 | nan | ||
| 155146047 | 186703 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay |
ChEMBL | 355 | 4 | 1 | 3 | 4.5 | N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 | nan | ||
| CHEMBL4878726 | 186703 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 20 uM of deoxycholic acid by HTRF assay |
ChEMBL | 355 | 4 | 1 | 3 | 4.5 | N#Cc1cc(COc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 | nan | ||
| 3238641 | 31413 | None | 31 | Human | Functional | pIC50 | = | 7 | 7.0 | 354 | 2 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 258 | 5 | 1 | 3 | 3.0 | COc1ccc(OCc2cccc(C(=O)O)c2)cc1 | nan | ||
| CHEMBL1402510 | 31413 | None | 31 | Human | Functional | pIC50 | = | 7 | 7.0 | 354 | 2 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 258 | 5 | 1 | 3 | 3.0 | COc1ccc(OCc2cccc(C(=O)O)c2)cc1 | nan | ||
| 2566134 | 69135 | None | 7 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 312 | 4 | 1 | 2 | 5.0 | O=C(O)c1cccc(CSc2ccc(Cl)cc2Cl)c1 | nan | ||
| CHEMBL1923999 | 69135 | None | 7 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 312 | 4 | 1 | 2 | 5.0 | O=C(O)c1cccc(CSc2ccc(Cl)cc2Cl)c1 | nan | ||
| 584653 | 184524 | None | 34 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 306 | 4 | 1 | 2 | 3.7 | O=C(O)c1cccc(COc2ccc(Br)cc2)c1 | nan | ||
| CHEMBL4846114 | 184524 | None | 34 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 306 | 4 | 1 | 2 | 3.7 | O=C(O)c1cccc(COc2ccc(Br)cc2)c1 | nan | ||
| 155153910 | 184529 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 312 | 4 | 1 | 2 | 4.8 | O=C(O)c1cccc(COc2cc3ccccc3cc2Cl)c1 | nan | ||
| CHEMBL4846170 | 184529 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 312 | 4 | 1 | 2 | 4.8 | O=C(O)c1cccc(COc2cc3ccccc3cc2Cl)c1 | nan | ||
| 155145976 | 184562 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 331 | 4 | 1 | 3 | 4.0 | O=C(O)c1cccc(COc2ncc(C(F)(F)F)cc2Cl)c1 | nan | ||
| CHEMBL4846676 | 184562 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 331 | 4 | 1 | 3 | 4.0 | O=C(O)c1cccc(COc2ncc(C(F)(F)F)cc2Cl)c1 | nan | ||
| 155154008 | 184580 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 368 | 5 | 1 | 3 | 4.2 | N#CCNC(=O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1 | nan | ||
| CHEMBL4846959 | 184580 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 368 | 5 | 1 | 3 | 4.2 | N#CCNC(=O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1 | nan | ||
| 155154202 | 184595 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 407 | 5 | 1 | 4 | 3.6 | CS(=O)(=O)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 | nan | ||
| CHEMBL4847181 | 184595 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 407 | 5 | 1 | 4 | 3.6 | CS(=O)(=O)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 | nan | ||
| 155153982 | 184605 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 302 | 5 | 1 | 2 | 4.5 | O=C(O)c1cccc(COc2ccc(C3CC3)cc2Cl)c1 | nan | ||
| CHEMBL4847374 | 184605 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 302 | 5 | 1 | 2 | 4.5 | O=C(O)c1cccc(COc2ccc(C3CC3)cc2Cl)c1 | nan | ||
| 7015981 | 184663 | None | 27 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 296 | 4 | 1 | 2 | 4.3 | O=C(O)c1cccc(COc2cccc(Cl)c2Cl)c1 | nan | ||
| CHEMBL4848369 | 184663 | None | 27 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 296 | 4 | 1 | 2 | 4.3 | O=C(O)c1cccc(COc2cccc(Cl)c2Cl)c1 | nan | ||
| 155154180 | 184689 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 386 | 6 | 2 | 3 | 3.2 | NC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 | nan | ||
| CHEMBL4848664 | 184689 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 386 | 6 | 2 | 3 | 3.2 | NC(=O)CNC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 | nan | ||
| 114322379 | 184698 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 287 | 4 | 1 | 3 | 3.5 | N#Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1 | nan | ||
| CHEMBL4848825 | 184698 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 287 | 4 | 1 | 3 | 3.5 | N#Cc1c(Cl)cccc1OCc1cccc(C(=O)O)c1 | nan | ||
| 155153838 | 184726 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 302 | 4 | 1 | 3 | 4.3 | O=C(O)c1cccc(COc2ccc3sccc3c2)c1F | nan | ||
| CHEMBL4849270 | 184726 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 302 | 4 | 1 | 3 | 4.3 | O=C(O)c1cccc(COc2ccc3sccc3c2)c1F | nan | ||
| 155153758 | 184752 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 291 | 4 | 0 | 4 | 3.4 | COC(=O)c1cccc(COc2ccc(Cl)cc2C)n1 | nan | ||
| CHEMBL4849588 | 184752 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 291 | 4 | 0 | 4 | 3.4 | COC(=O)c1cccc(COc2ccc(Cl)cc2C)n1 | nan | ||
| 155153970 | 184782 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 340 | 4 | 1 | 2 | 4.4 | O=C(O)c1cccc(COc2cccc(Br)c2Cl)c1 | nan | ||
| CHEMBL4849913 | 184782 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 340 | 4 | 1 | 2 | 4.4 | O=C(O)c1cccc(COc2cccc(Br)c2Cl)c1 | nan | ||
| 155154172 | 184835 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 330 | 4 | 1 | 2 | 4.6 | O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1 | nan | ||
| CHEMBL4850633 | 184835 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 330 | 4 | 1 | 2 | 4.6 | O=C(O)c1cccc(COc2ccc(Cl)cc2C(F)(F)F)c1 | nan | ||
| 155154044 | 184910 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 415 | 6 | 2 | 3 | 4.5 | CC(C)(NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O | nan | ||
| CHEMBL4851715 | 184910 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 415 | 6 | 2 | 3 | 4.5 | CC(C)(NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1)C(=O)O | nan | ||
| 155145940 | 185120 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 311 | 3 | 0 | 2 | 4.8 | N#Cc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 | nan | ||
| CHEMBL4854872 | 185120 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 311 | 3 | 0 | 2 | 4.8 | N#Cc1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 | nan | ||
| 84614649 | 185140 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 278 | 5 | 1 | 2 | 3.9 | O=C(O)c1cccc(COc2ccc(C(F)F)cc2)c1 | nan | ||
| CHEMBL4855127 | 185140 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 278 | 5 | 1 | 2 | 3.9 | O=C(O)c1cccc(COc2ccc(C(F)F)cc2)c1 | nan | ||
| 155153740 | 185159 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 325 | 5 | 1 | 3 | 4.2 | Cc1cc(-n2cccc2)ccc1OCc1cccc(C(=O)O)c1F | nan | ||
| CHEMBL4855384 | 185159 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 325 | 5 | 1 | 3 | 4.2 | Cc1cc(-n2cccc2)ccc1OCc1cccc(C(=O)O)c1F | nan | ||
| 107881084 | 185172 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 314 | 4 | 1 | 2 | 4.4 | O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1F | nan | ||
| CHEMBL4855567 | 185172 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 314 | 4 | 1 | 2 | 4.4 | O=C(O)c1cc(COc2ccc(Cl)cc2Cl)ccc1F | nan | ||
| 155154045 | 185208 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 493 | 8 | 3 | 4 | 5.1 | O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 | nan | ||
| CHEMBL4856071 | 185208 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 493 | 8 | 3 | 4 | 5.1 | O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 | nan | ||
| 155146040 | 185230 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 349 | 1 | 1 | 2 | 4.3 | N#Cc1cc(C#Cc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 | nan | ||
| CHEMBL4856356 | 185230 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assayAntagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay |
ChEMBL | 349 | 1 | 1 | 2 | 4.3 | N#Cc1cc(C#Cc2ccc(C(F)(F)F)cc2Cl)cc(C(=O)O)c1 | nan | ||
Showing 1 to 50 of 550 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
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| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
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Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| No data available in table | ||||||||||||||||||||||
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