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Ligand source activities (1 row/activity)
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
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Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
| CHEMBL1402510 | 31413 | None | 31 | Human | Functional | IC50 | = | 100.00 | 7.00 | 354 | 2 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 258.1 | 5 | 1 | 3 | 2.97 | COc1ccc(OCc2cccc(C(=O)O)c2)cc1 | - | |
| CHEMBL1404550 | 31626 | None | 34 | Human | Functional | IC50 | = | 500.00 | 6.30 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 278.1 | 4 | 1 | 2 | 4.12 | O=C(O)c1cccc(COc2cccc3ccccc23)c1 | - | |
| CHEMBL1468323 | 39014 | None | 29 | Human | Functional | IC50 | = | 1000.00 | 6.00 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 268.1 | 4 | 1 | 2 | 3.45 | O=C(O)c1cccc(COc2ccc3c(c2)CCC3)c1 | - | |
| CHEMBL1500515 | 42609 | None | 33 | Human | Functional | IC50 | = | 1000.00 | 6.00 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 286.0 | 4 | 1 | 3 | 3.86 | O=C(O)c1ccc(COc2ccc(Cl)cc2Cl)o1 | - | |
| CHEMBL1587117 | 52065 | None | 30 | Human | Functional | IC50 | = | 1000.00 | 6.00 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 272.1 | 6 | 1 | 3 | 3.36 | CCOc1ccc(OCc2cccc(C(=O)O)c2)cc1 | - | |
| CHEMBL1923999 | 69135 | None | 7 | Human | Functional | IC50 | = | 100.00 | 7.00 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 312.0 | 4 | 1 | 2 | 4.98 | O=C(O)c1cccc(CSc2ccc(Cl)cc2Cl)c1 | - | |
| CHEMBL4846114 | 184524 | None | 34 | Human | Functional | IC50 | = | 100.00 | 7.00 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 306.0 | 4 | 1 | 2 | 3.73 | O=C(O)c1cccc(COc2ccc(Br)cc2)c1 | - | |
| CHEMBL4846170 | 184529 | None | 0 | Human | Functional | IC50 | = | 100.00 | 7.00 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 312.1 | 4 | 1 | 2 | 4.77 | O=C(O)c1cccc(COc2cc3ccccc3cc2Cl)c1 | - | |
| CHEMBL4846341 | 184541 | None | 0 | Human | Functional | IC50 | = | 1000.00 | 6.00 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 358.1 | 5 | 1 | 2 | 5.20 | CCc1c(COc2ccc(C(F)(F)F)cc2Cl)cccc1C(=O)O | - | |
| CHEMBL4846676 | 184562 | None | 0 | Human | Functional | IC50 | = | 100.00 | 7.00 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 331.0 | 4 | 1 | 3 | 4.03 | O=C(O)c1cccc(COc2ncc(C(F)(F)F)cc2Cl)c1 | - | |
| CHEMBL4846959 | 184580 | None | 0 | Human | Functional | IC50 | = | 100.00 | 7.00 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 368.1 | 5 | 1 | 3 | 4.19 | N#CCNC(=O)c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1 | - | |
| CHEMBL4847181 | 184595 | None | 0 | Human | Functional | IC50 | = | 100.00 | 7.00 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 407.0 | 5 | 1 | 4 | 3.63 | CS(=O)(=O)NC(=O)c1cccc(COc2ccc(C(F)(F)F)cc2Cl)c1 | - | |
| CHEMBL4847344 | 184602 | None | 0 | Human | Functional | IC50 | = | 500.00 | 6.30 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 336.1 | 5 | 1 | 2 | 4.86 | O=C(O)c1cccc(COc2ccc(C(F)(F)F)cc2C2CC2)c1 | - | |
| CHEMBL4847374 | 184605 | None | 0 | Human | Functional | IC50 | = | 100.00 | 7.00 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 302.1 | 5 | 1 | 2 | 4.50 | O=C(O)c1cccc(COc2ccc(C3CC3)cc2Cl)c1 | - | |
| CHEMBL4847516 | 184617 | None | 0 | Human | Functional | IC50 | = | 500.00 | 6.30 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 355.1 | 3 | 1 | 2 | 4.22 | O=C1NCCc2c(COc3ccc(C(F)(F)F)cc3Cl)cccc21 | - | |
| CHEMBL4847582 | 184620 | None | 0 | Human | Functional | IC50 | = | 500.00 | 6.30 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 278.1 | 4 | 1 | 2 | 3.55 | Cc1cc(F)c(F)cc1OCc1cccc(C(=O)O)c1 | - | |
| CHEMBL4847901 | 184644 | None | 12 | Human | Functional | IC50 | = | 1000.00 | 6.00 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 246.1 | 4 | 1 | 2 | 3.10 | O=C(O)c1cccc(COc2ccccc2F)c1 | - | |
| CHEMBL4848369 | 184663 | None | 27 | Human | Functional | IC50 | = | 100.00 | 7.00 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 296.0 | 4 | 1 | 2 | 4.27 | O=C(O)c1cccc(COc2cccc(Cl)c2Cl)c1 | - | |
| CHEMBL4848511 | 184677 | None | 30 | Human | Functional | IC50 | = | 1000.00 | 6.00 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 256.1 | 4 | 1 | 2 | 3.58 | Cc1ccc(OCc2cccc(C(=O)O)c2)c(C)c1 | - | |
| CHEMBL4848586 | 184683 | None | 0 | Human | Functional | IC50 | = | 1000.00 | 6.00 | - | 1 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark for 1 hr at 37 degree C and then incubated for 30 mins at room temperature in presence of 10 pM of bilirubin by HTRF assay | ChEMBL | 425.1 | 4 | 0 | 3 | 4.80 | O=C(c1ccc(COc2ccc(C(F)(F)F)cc2Cl)cc1)N1CCC2(COC2)C1 | - | |
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