GPCRdb

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

CHEMBL1742484	60306	None	2	Human	Binding	EC50	=	28.00	7.55	-	6	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL1742484	60306	None	2	Human	Binding	EC50	=	28.18	7.55	-	6	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL1742484	60306	None	2	Human	Binding	EC50	=	13.00	7.89	-	6	Agonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 V159F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL1742484	60306	None	2	Human	Binding	EC50	=	12.59	7.90	-	6	Agonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 V159F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL1742484	60306	None	2	Human	Binding	EC50	=	22.00	7.66	-	6	Agonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 A163F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL1742484	60306	None	2	Human	Binding	EC50	=	22.39	7.65	-	6	Agonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 A163F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL1742484	60306	None	2	Mouse	Binding	EC50	=	25.00	7.60	-	6	Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/acs.jmedchem.5b01925
CHEMBL1742484	60306	None	2	Mouse	Binding	EC50	=	24.55	7.61	-	6	Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/acs.jmedchem.5b01925
CHEMBL1742484	60306	None	2	Mouse	Binding	EC50	=	20.00	7.70	-	6	Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/acs.jmedchem.0c01126
CHEMBL1742484	60306	None	2	Mouse	Binding	EC50	=	19.50	7.71	-	6	Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/acs.jmedchem.0c01126
CHEMBL3577137	121214	None	0	Human	Binding	EC50	=	25.00	7.60	-	3	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	507.3	24	3	7	5.50	CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL3577137	121214	None	0	Human	Binding	EC50	=	25.12	7.60	-	3	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	507.3	24	3	7	5.50	CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL3577137	121214	None	0	Mouse	Binding	EC50	=	20.00	7.70	-	3	Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis	ChEMBL	507.3	24	3	7	5.50	CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/acs.jmedchem.0c01126
CHEMBL3577137	121214	None	0	Mouse	Binding	EC50	=	19.50	7.71	-	3	Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis	ChEMBL	507.3	24	3	7	5.50	CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/acs.jmedchem.0c01126
CHEMBL3577138	121215	None	0	Human	Binding	EC50	=	39.00	7.41	-	3	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL3577138	121215	None	0	Human	Binding	EC50	=	38.90	7.41	-	3	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL3577140	121216	None	0	Human	Binding	EC50	=	58.00	7.24	-	2	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	535.3	24	3	7	6.14	CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C)(C)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL3577140	121216	None	0	Human	Binding	EC50	=	58.88	7.23	-	2	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	535.3	24	3	7	6.14	CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C)(C)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL3577141	121217	None	0	Human	Binding	EC50	=	150.00	6.82	-	2	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	525.3	24	3	7	5.45	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL3577141	121217	None	0	Human	Binding	EC50	=	144.54	6.84	-	2	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	525.3	24	3	7	5.45	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082

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Ligand source activities (1 row/activity)