GPCRdb

Ligand source activities (1 row/activity)

Affinity
Potency

Search:

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

CHEMBL1742484	60306	None	2	Human	Binding	EC50	=	28.00	7.55	-	6	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL1742484	60306	None	2	Human	Binding	EC50	=	28.18	7.55	-	6	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL1742484	60306	None	2	Human	Binding	EC50	=	13.00	7.89	-	6	Agonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 V159F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL1742484	60306	None	2	Human	Binding	EC50	=	12.59	7.90	-	6	Agonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 V159F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL1742484	60306	None	2	Human	Binding	EC50	=	22.00	7.66	-	6	Agonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 A163F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL1742484	60306	None	2	Human	Binding	EC50	=	22.39	7.65	-	6	Agonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 A163F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL1742484	60306	None	2	Mouse	Binding	EC50	=	25.00	7.60	-	6	Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/acs.jmedchem.5b01925
CHEMBL1742484	60306	None	2	Mouse	Binding	EC50	=	24.55	7.61	-	6	Agonist activity at mouse P2Y10 receptor expressed in HEK293A cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/acs.jmedchem.5b01925
CHEMBL1742484	60306	None	2	Mouse	Binding	EC50	=	20.00	7.70	-	6	Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/acs.jmedchem.0c01126
CHEMBL1742484	60306	None	2	Mouse	Binding	EC50	=	19.50	7.71	-	6	Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/acs.jmedchem.0c01126
CHEMBL3577137	121214	None	0	Human	Binding	EC50	=	25.00	7.60	-	3	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	507.3	24	3	7	5.50	CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL3577137	121214	None	0	Human	Binding	EC50	=	25.12	7.60	-	3	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	507.3	24	3	7	5.50	CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL3577137	121214	None	0	Mouse	Binding	EC50	=	20.00	7.70	-	3	Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis	ChEMBL	507.3	24	3	7	5.50	CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/acs.jmedchem.0c01126
CHEMBL3577137	121214	None	0	Mouse	Binding	EC50	=	19.50	7.71	-	3	Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis	ChEMBL	507.3	24	3	7	5.50	CCCCCCCC/C=C\CCCCCCCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/acs.jmedchem.0c01126
CHEMBL3577138	121215	None	0	Human	Binding	EC50	=	39.00	7.41	-	3	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL3577138	121215	None	0	Human	Binding	EC50	=	38.90	7.41	-	3	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL3577140	121216	None	0	Human	Binding	EC50	=	58.00	7.24	-	2	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	535.3	24	3	7	6.14	CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C)(C)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL3577140	121216	None	0	Human	Binding	EC50	=	58.88	7.23	-	2	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	535.3	24	3	7	6.14	CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C)(C)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL3577141	121217	None	0	Human	Binding	EC50	=	150.00	6.82	-	2	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	525.3	24	3	7	5.45	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082
CHEMBL3577141	121217	None	0	Human	Binding	EC50	=	144.54	6.84	-	2	Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay	ChEMBL	525.3	24	3	7	5.45	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1021/jm5020082

Showing 1 to 20 of 180 entries

Search:

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

CHEMBL1742484	60306	None	2	Human	Functional	EC50	=	15.00	7.82	1	6	Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL1742484	60306	None	2	Human	Functional	EC50	=	14.45	7.84	1	6	Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL1742484	60306	None	2	Human	Functional	EC50	=	10.00	8.00	1	6	Agonist activity at wildtype N-terminal FLAG-tagged human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL1742484	60306	None	2	Human	Functional	EC50	=	10.47	7.98	1	6	Agonist activity at wildtype N-terminal FLAG-tagged human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL1742484	60306	None	2	Mouse	Functional	EC50	=	21.00	7.68	-1	6	Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL1742484	60306	None	2	Mouse	Functional	EC50	=	20.42	7.69	-1	6	Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	523.3	24	4	8	4.47	CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL3577262	121256	None	0	Human	Functional	EC50	=	2.00	8.70	-1	2	Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	581.3	23	3	8	5.25	CCCCCCCCCCCOc1ccccc1CCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL3577262	121256	None	0	Human	Functional	EC50	=	1.95	8.71	-1	2	Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	581.3	23	3	8	5.25	CCCCCCCCCCCOc1ccccc1CCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL3577262	121256	None	0	Mouse	Functional	EC50	=	1.50	8.82	1	2	Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	581.3	23	3	8	5.25	CCCCCCCCCCCOc1ccccc1CCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL3577262	121256	None	0	Mouse	Functional	EC50	=	1.51	8.82	1	2	Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	581.3	23	3	8	5.25	CCCCCCCCCCCOc1ccccc1CCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL4072692	157039	None	0	Mouse	Functional	EC50	=	90.00	7.05	-1	3	Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	573.2	17	3	9	4.47	N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL4072692	157039	None	0	Mouse	Functional	EC50	=	93.33	7.03	-1	3	Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	573.2	17	3	9	4.47	N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(Oc2ccccc2)c1)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL4099594	159388	None	0	Mouse	Functional	EC50	=	5.70	8.24	-	1	Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	557.2	16	3	8	4.34	N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(-c2ccccc2)c1)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL4099594	159388	None	0	Mouse	Functional	EC50	=	5.75	8.24	-	1	Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	557.2	16	3	8	4.34	N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1OCc1cccc(-c2ccccc2)c1)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL5393782	194941	None	0	Mouse	Functional	EC50	=	2.70	8.57	602	2	Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	544.3	23	3	8	4.41	CCCCCCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL5393782	194941	None	0	Mouse	Functional	EC50	=	2.75	8.56	602	2	Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	544.3	23	3	8	4.41	CCCCCCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL5394298	194971	None	0	Human	Functional	EC50	=	5128.61	5.29	-5	2	Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	543.2	15	3	8	4.56	N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1ccccc1-c1ccccc1)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL5394298	194971	None	0	Mouse	Functional	EC50	=	890.00	6.05	5	2	Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	543.2	15	3	8	4.56	N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1ccccc1-c1ccccc1)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL5394298	194971	None	0	Mouse	Functional	EC50	=	891.25	6.05	5	2	Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	543.2	15	3	8	4.56	N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1ccccc1-c1ccccc1)C(=O)O	https://dx.doi.org/10.1016/j.ejmech.2023.115271
CHEMBL5394475	194989	None	0	Mouse	Functional	EC50	=	7.10	8.15	-	1	Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay	ChEMBL	580.3	21	3	9	4.04	CCCCCCOc1cccc(COc2ccccc2CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(N)=O)c1	https://dx.doi.org/10.1016/j.ejmech.2023.115271

Showing 1 to 20 of 120 entries

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)