Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 172460467 | 196302 | None | 0 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | 21 | 2 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 619 | 16 | 3 | 8 | 6.2 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1ccc(-c2cccc(-c3ccccc3)c2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5421007 | 196302 | None | 0 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | 21 | 2 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 619 | 16 | 3 | 8 | 6.2 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1ccc(-c2cccc(-c3ccccc3)c2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 172460467 | 196302 | None | 0 | Mouse | Functional | pEC50 | = | 9 | 9.0 | 21 | 2 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 619 | 16 | 3 | 8 | 6.2 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1ccc(-c2cccc(-c3ccccc3)c2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5421007 | 196302 | None | 0 | Mouse | Functional | pEC50 | = | 9 | 9.0 | 21 | 2 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 619 | 16 | 3 | 8 | 6.2 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1ccc(-c2cccc(-c3ccccc3)c2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 172441760 | 195386 | None | 0 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 571 | 16 | 3 | 9 | 4.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CC(=O)Cc1ccccc1Oc1ccc(-c2ccccc2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5402557 | 195386 | None | 0 | Mouse | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 571 | 16 | 3 | 9 | 4.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CC(=O)Cc1ccccc1Oc1ccc(-c2ccccc2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 122177589 | 121256 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | 1 | 2 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 581 | 23 | 3 | 8 | 5.3 | CCCCCCCCCCCOc1ccccc1CCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL3577262 | 121256 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | 1 | 2 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 581 | 23 | 3 | 8 | 5.3 | CCCCCCCCCCCOc1ccccc1CCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 122177589 | 121256 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | 1 | 2 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 581 | 23 | 3 | 8 | 5.3 | CCCCCCCCCCCOc1ccccc1CCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL3577262 | 121256 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | 1 | 2 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 581 | 23 | 3 | 8 | 5.3 | CCCCCCCCCCCOc1ccccc1CCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 172469090 | 197060 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 482 | 14 | 4 | 9 | 2.5 | Nc1ccc(Oc2ccccc2CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)cc1 | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5437846 | 197060 | None | 0 | Mouse | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 482 | 14 | 4 | 9 | 2.5 | Nc1ccc(Oc2ccccc2CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)cc1 | 10.1016/j.ejmech.2023.115271 | ||
| 170070315 | 195083 | None | 0 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | 3 | 2 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 695 | 17 | 3 | 8 | 7.9 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1ccc(-c2cc(-c3ccccc3)cc(-c3ccccc3)c2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5396462 | 195083 | None | 0 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | 3 | 2 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 695 | 17 | 3 | 8 | 7.9 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1ccc(-c2cc(-c3ccccc3)cc(-c3ccccc3)c2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 170070315 | 195083 | None | 0 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | 3 | 2 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 695 | 17 | 3 | 8 | 7.9 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1ccc(-c2cc(-c3ccccc3)cc(-c3ccccc3)c2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5396462 | 195083 | None | 0 | Mouse | Functional | pEC50 | = | 8.7 | 8.7 | 3 | 2 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 695 | 17 | 3 | 8 | 7.9 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1ccc(-c2cc(-c3ccccc3)cc(-c3ccccc3)c2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 122177589 | 121256 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -1 | 2 | Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 581 | 23 | 3 | 8 | 5.3 | CCCCCCCCCCCOc1ccccc1CCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL3577262 | 121256 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -1 | 2 | Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 581 | 23 | 3 | 8 | 5.3 | CCCCCCCCCCCOc1ccccc1CCC(=O)OCC(F)(F)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 9547099 | 60306 | None | 2 | Human | Functional | pEC50 | = | 8 | 8.0 | 1 | 6 | Agonist activity at wildtype N-terminal FLAG-tagged human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at wildtype N-terminal FLAG-tagged human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 523 | 24 | 4 | 8 | 4.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL1742484 | 60306 | None | 2 | Human | Functional | pEC50 | = | 8 | 8.0 | 1 | 6 | Agonist activity at wildtype N-terminal FLAG-tagged human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at wildtype N-terminal FLAG-tagged human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 523 | 24 | 4 | 8 | 4.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 172450552 | 195842 | None | 0 | Mouse | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 557 | 15 | 3 | 8 | 4.9 | Cc1ccc(-c2ccc(Oc3ccccc3CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)cc2)cc1 | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5411720 | 195842 | None | 0 | Mouse | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 557 | 15 | 3 | 8 | 4.9 | Cc1ccc(-c2ccc(Oc3ccccc3CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)cc2)cc1 | 10.1016/j.ejmech.2023.115271 | ||
| 9547099 | 60306 | None | 2 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 1 | 6 | Agonist activity at wildtype N-terminal FLAG-tagged human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at wildtype N-terminal FLAG-tagged human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 523 | 24 | 4 | 8 | 4.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL1742484 | 60306 | None | 2 | Human | Functional | pEC50 | = | 8.0 | 8.0 | 1 | 6 | Agonist activity at wildtype N-terminal FLAG-tagged human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at wildtype N-terminal FLAG-tagged human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 523 | 24 | 4 | 8 | 4.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 172451712 | 195934 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -15 | 2 | Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 619 | 16 | 3 | 8 | 6.2 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1ccc(-c2ccccc2-c2ccccc2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5413591 | 195934 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -15 | 2 | Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 619 | 16 | 3 | 8 | 6.2 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1ccc(-c2ccccc2-c2ccccc2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 172461950 | 196819 | None | 0 | Mouse | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 641 | 20 | 3 | 10 | 4.9 | N[C@@H](COP(=O)(O)OCCCCCOC(=O)CC(=O)CC(=O)Cc1ccccc1Oc1ccc(-c2ccccc2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5432816 | 196819 | None | 0 | Mouse | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 641 | 20 | 3 | 10 | 4.9 | N[C@@H](COP(=O)(O)OCCCCCOC(=O)CC(=O)CC(=O)Cc1ccccc1Oc1ccc(-c2ccccc2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 172451712 | 195934 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -15 | 2 | Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 619 | 16 | 3 | 8 | 6.2 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1ccc(-c2ccccc2-c2ccccc2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5413591 | 195934 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -15 | 2 | Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 619 | 16 | 3 | 8 | 6.2 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1ccc(-c2ccccc2-c2ccccc2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 172441760 | 195386 | None | 0 | Mouse | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 571 | 16 | 3 | 9 | 4.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CC(=O)Cc1ccccc1Oc1ccc(-c2ccccc2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5402557 | 195386 | None | 0 | Mouse | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 571 | 16 | 3 | 9 | 4.1 | N[C@@H](COP(=O)(O)OCCCOC(=O)CC(=O)Cc1ccccc1Oc1ccc(-c2ccccc2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 172450552 | 195842 | None | 0 | Mouse | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 557 | 15 | 3 | 8 | 4.9 | Cc1ccc(-c2ccc(Oc3ccccc3CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)cc2)cc1 | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5411720 | 195842 | None | 0 | Mouse | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 557 | 15 | 3 | 8 | 4.9 | Cc1ccc(-c2ccc(Oc3ccccc3CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)cc2)cc1 | 10.1016/j.ejmech.2023.115271 | ||
| 172464660 | 196764 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -5 | 2 | Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 619 | 16 | 3 | 8 | 6.2 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1cc(-c2ccccc2)cc(-c2ccccc2)c1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5431715 | 196764 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -5 | 2 | Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 619 | 16 | 3 | 8 | 6.2 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1cc(-c2ccccc2)cc(-c2ccccc2)c1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 172464660 | 196764 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -5 | 2 | Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 619 | 16 | 3 | 8 | 6.2 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1cc(-c2ccccc2)cc(-c2ccccc2)c1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5431715 | 196764 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -5 | 2 | Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 619 | 16 | 3 | 8 | 6.2 | N[C@@H](COP(=O)(O)OCCCOC(=O)CCc1ccccc1Oc1cc(-c2ccccc2)cc(-c2ccccc2)c1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 172471206 | 197142 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 495 | 14 | 3 | 8 | 3.5 | Cc1cc(C)cc(Oc2ccccc2CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5439798 | 197142 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 495 | 14 | 3 | 8 | 3.5 | Cc1cc(C)cc(Oc2ccccc2CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1016/j.ejmech.2023.115271 | ||
| 172471206 | 197142 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 495 | 14 | 3 | 8 | 3.5 | Cc1cc(C)cc(Oc2ccccc2CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5439798 | 197142 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 495 | 14 | 3 | 8 | 3.5 | Cc1cc(C)cc(Oc2ccccc2CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1016/j.ejmech.2023.115271 | ||
| 172448147 | 195581 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 585 | 17 | 3 | 9 | 4.5 | N[C@@H](COP(=O)(O)OCCCCOC(=O)CC(=O)Cc1ccccc1Oc1ccc(-c2ccccc2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5406472 | 195581 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 585 | 17 | 3 | 9 | 4.5 | N[C@@H](COP(=O)(O)OCCCCOC(=O)CC(=O)Cc1ccccc1Oc1ccc(-c2ccccc2)cc1)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 172449920 | 196060 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 481 | 14 | 3 | 8 | 3.2 | Cc1ccccc1Oc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5416109 | 196060 | None | 0 | Mouse | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 481 | 14 | 3 | 8 | 3.2 | Cc1ccccc1Oc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 172451719 | 195935 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 599 | 15 | 3 | 8 | 5.9 | CC(C)(C)c1cccc(-c2ccc(Oc3ccccc3CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)cc2)c1 | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL5413598 | 195935 | None | 0 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at mouse LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 599 | 15 | 3 | 8 | 5.9 | CC(C)(C)c1cccc(-c2ccc(Oc3ccccc3CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O)cc2)c1 | 10.1016/j.ejmech.2023.115271 | ||
| 9547099 | 60306 | None | 2 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 1 | 6 | Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 523 | 24 | 4 | 8 | 4.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL1742484 | 60306 | None | 2 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 1 | 6 | Agonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at human LPS2/P2Y10 transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 523 | 24 | 4 | 8 | 4.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
Showing 1 to 50 of 242 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 78319665 | 180599 | None | 0 | Mouse | Binding | pEC50 | = | 9.0 | 9.0 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
| CHEMBL4753103 | 180599 | None | 0 | Mouse | Binding | pEC50 | = | 9.0 | 9.0 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
| 78319665 | 180599 | None | 0 | Mouse | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
| CHEMBL4753103 | 180599 | None | 0 | Mouse | Binding | pEC50 | = | 9 | 9.0 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
| 122177528 | 121254 | None | 0 | Human | Binding | pEC50 | = | 8.9 | 8.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 563 | 23 | 3 | 8 | 5.0 | CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577182 | 121254 | None | 0 | Human | Binding | pEC50 | = | 8.9 | 8.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 563 | 23 | 3 | 8 | 5.0 | CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177528 | 121254 | None | 0 | Human | Binding | pEC50 | = | 8.9 | 8.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 563 | 23 | 3 | 8 | 5.0 | CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577182 | 121254 | None | 0 | Human | Binding | pEC50 | = | 8.9 | 8.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 563 | 23 | 3 | 8 | 5.0 | CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177525 | 121251 | None | 0 | Human | Binding | pEC50 | = | 8.8 | 8.8 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 545 | 23 | 3 | 8 | 5.0 | CCCCCCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577179 | 121251 | None | 0 | Human | Binding | pEC50 | = | 8.8 | 8.8 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 545 | 23 | 3 | 8 | 5.0 | CCCCCCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177525 | 121251 | None | 0 | Human | Binding | pEC50 | = | 8.8 | 8.8 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 545 | 23 | 3 | 8 | 5.0 | CCCCCCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577179 | 121251 | None | 0 | Human | Binding | pEC50 | = | 8.8 | 8.8 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 545 | 23 | 3 | 8 | 5.0 | CCCCCCCCCCCOc1ccccc1CCC(=O)OCCCOP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177517 | 121243 | None | 0 | Human | Binding | pEC50 | = | 8.7 | 8.7 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 561 | 23 | 4 | 9 | 4.0 | CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577171 | 121243 | None | 0 | Human | Binding | pEC50 | = | 8.7 | 8.7 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 561 | 23 | 4 | 9 | 4.0 | CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177514 | 121239 | None | 0 | Human | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 505 | 19 | 4 | 9 | 2.4 | CCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| CHEMBL3577168 | 121239 | None | 0 | Human | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 505 | 19 | 4 | 9 | 2.4 | CCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| 122177514 | 121239 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 505 | 19 | 4 | 9 | 2.4 | CCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| CHEMBL3577168 | 121239 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 505 | 19 | 4 | 9 | 2.4 | CCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| 122177504 | 121230 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 522 | 24 | 5 | 7 | 4.0 | CCCCCCCC/C=C\CCCCCCCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577156 | 121230 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 522 | 24 | 5 | 7 | 4.0 | CCCCCCCC/C=C\CCCCCCCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177518 | 121244 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 561 | 23 | 4 | 9 | 4.0 | CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| CHEMBL3577172 | 121244 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 561 | 23 | 4 | 9 | 4.0 | CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| 118555095 | 180806 | None | 0 | Mouse | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
| CHEMBL4755564 | 180806 | None | 0 | Mouse | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
| 122177518 | 121244 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 561 | 23 | 4 | 9 | 4.0 | CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| CHEMBL3577172 | 121244 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 561 | 23 | 4 | 9 | 4.0 | CCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| 118555095 | 180806 | None | 0 | Mouse | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
| CHEMBL4755564 | 180806 | None | 0 | Mouse | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
| 9547099 | 60306 | None | 2 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 V159F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 V159F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 523 | 24 | 4 | 8 | 4.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL1742484 | 60306 | None | 2 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 V159F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 V159F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 523 | 24 | 4 | 8 | 4.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 122177521 | 121247 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 617 | 27 | 4 | 9 | 5.5 | CCCCCCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| CHEMBL3577175 | 121247 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 617 | 27 | 4 | 9 | 5.5 | CCCCCCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| 122177513 | 121238 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 505 | 19 | 4 | 9 | 2.4 | CCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577167 | 121238 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 505 | 19 | 4 | 9 | 2.4 | CCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177504 | 121230 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 522 | 24 | 5 | 7 | 4.0 | CCCCCCCC/C=C\CCCCCCCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577156 | 121230 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 522 | 24 | 5 | 7 | 4.0 | CCCCCCCC/C=C\CCCCCCCC(=O)NC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 122177513 | 121238 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 505 | 19 | 4 | 9 | 2.4 | CCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| CHEMBL3577167 | 121238 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 505 | 19 | 4 | 9 | 2.4 | CCCCCCCOc1ccccc1CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/jm5020082 | ||
| 9547099 | 60306 | None | 2 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 V159F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 V159F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 523 | 24 | 4 | 8 | 4.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| CHEMBL1742484 | 60306 | None | 2 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 V159F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assayAgonist activity at N-terminal FLAG-tagged human LPS2/P2Y10 V159F mutant transfected in HEK293-A cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release by TGFalpha shedding assay |
ChEMBL | 523 | 24 | 4 | 8 | 4.5 | CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O | 10.1016/j.ejmech.2023.115271 | ||
| 122177521 | 121247 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 617 | 27 | 4 | 9 | 5.5 | CCCCCCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| CHEMBL3577175 | 121247 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Agonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assayAgonist activity at P2Y10 (unknown origin) transfected in HEK293A cells after 1 hr by TGFalpha shedding assay |
ChEMBL | 617 | 27 | 4 | 9 | 5.5 | CCCCCCCCCCCCCCCOc1cccc(CCC(=O)OC[C@@H](O)COP(=O)(O)OC[C@H](N)C(=O)O)c1 | 10.1021/jm5020082 | ||
| 162645155 | 179537 | None | 0 | Mouse | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
| CHEMBL4740368 | 179537 | None | 0 | Mouse | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
| 118555093 | 180732 | None | 0 | Mouse | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1COCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
| CHEMBL4754776 | 180732 | None | 0 | Mouse | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1COCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
| 162645155 | 179537 | None | 0 | Mouse | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
| CHEMBL4740368 | 179537 | None | 0 | Mouse | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@@H]1CCOC[C@@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
| 118555093 | 180732 | None | 0 | Mouse | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1COCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
| CHEMBL4754776 | 180732 | None | 0 | Mouse | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysisAgonist activity at mouse P2Y10 expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis |
ChEMBL | 587 | 21 | 3 | 9 | 4.8 | CCCCCCCCCCCOc1ccccc1CCC(=O)O[C@H]1COCC[C@H]1OP(=O)(O)OC[C@H](N)C(=O)O | 10.1021/acs.jmedchem.0c01126 | ||
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