GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1146	10634	56	None	-	1	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse TAAR5 expressed in HEK293 cells assessed as increase in cAMP release after 30 mins by BRET assay relative to controlAgonist activity at mouse TAAR5 expressed in HEK293 cells assessed as increase in cAMP release after 30 mins by BRET assay relative to control	ChEMBL	59	0	0	1	0.2	CN(C)C	10.1039/C5MD00490J
	5521	10634	56	None	-	1	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse TAAR5 expressed in HEK293 cells assessed as increase in cAMP release after 30 mins by BRET assay relative to controlAgonist activity at mouse TAAR5 expressed in HEK293 cells assessed as increase in cAMP release after 30 mins by BRET assay relative to control	ChEMBL	59	0	0	1	0.2	CN(C)C	10.1039/C5MD00490J
	CHEMBL439723	10634	56	None	-	1	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse TAAR5 expressed in HEK293 cells assessed as increase in cAMP release after 30 mins by BRET assay relative to controlAgonist activity at mouse TAAR5 expressed in HEK293 cells assessed as increase in cAMP release after 30 mins by BRET assay relative to control	ChEMBL	59	0	0	1	0.2	CN(C)C	10.1039/C5MD00490J
	56946474	78291	0	None	-	1	Mouse	4.5	pIC50	=	4.5	Functional	Antagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assayAntagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assay	ChEMBL	403	9	1	4	4.8	COc1ccccc1OCCNCC1CCC(c2ccccc2)(c2ccccc2)O1	10.1039/C5MD00490J
	CHEMBL1946779	78291	0	None	-	1	Mouse	4.5	pIC50	=	4.5	Functional	Antagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assayAntagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assay	ChEMBL	403	9	1	4	4.8	COc1ccccc1OCCNCC1CCC(c2ccccc2)(c2ccccc2)O1	10.1039/C5MD00490J
	CHEMBL1962769	78291	0	None	-	1	Mouse	4.5	pIC50	=	4.5	Functional	Antagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assayAntagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assay	ChEMBL	403	9	1	4	4.8	COc1ccccc1OCCNCC1CCC(c2ccccc2)(c2ccccc2)O1	10.1039/C5MD00490J
	56946573	78301	0	None	-	1	Mouse	5.3	pIC50	=	5.3	Functional	Antagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assayAntagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assay	ChEMBL	428	6	0	4	4.9	COc1ccccc1N1CCN(CC2CCC(c3ccccc3)(c3ccccc3)O2)CC1	10.1039/C5MD00490J
	CHEMBL1946780	78301	0	None	-	1	Mouse	5.3	pIC50	=	5.3	Functional	Antagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assayAntagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assay	ChEMBL	428	6	0	4	4.9	COc1ccccc1N1CCN(CC2CCC(c3ccccc3)(c3ccccc3)O2)CC1	10.1039/C5MD00490J
	CHEMBL1962870	78301	0	None	-	1	Mouse	5.3	pIC50	=	5.3	Functional	Antagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assayAntagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assay	ChEMBL	428	6	0	4	4.9	COc1ccccc1N1CCN(CC2CCC(c3ccccc3)(c3ccccc3)O2)CC1	10.1039/C5MD00490J
	11723	8207	0	None	-	1	Mouse	6.2	pEC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	73	1	0	1	0.6	CCN(C)C	17088868
	5523	8207	0	None	-	1	Mouse	6.2	pEC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	73	1	0	1	0.6	CCN(C)C	17088868
	CHEMBL609099	8207	0	None	-	1	Mouse	6.2	pEC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	73	1	0	1	0.6	CCN(C)C	17088868
	1146	10634	56	None	-	1	Mouse	6.5	pEC50	=	6.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	59	0	0	1	0.2	CN(C)C	16878137
	5521	10634	56	None	-	1	Mouse	6.5	pEC50	=	6.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	59	0	0	1	0.2	CN(C)C	16878137
	CHEMBL439723	10634	56	None	-	1	Mouse	6.5	pEC50	=	6.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	59	0	0	1	0.2	CN(C)C	16878137

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	9950514	18630	13	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Inverse agonist activity at human TAAR5 expressed in HEK293 cells by Alphascreen assayInverse agonist activity at human TAAR5 expressed in HEK293 cells by Alphascreen assay	ChEMBL	355	4	2	3	3.3	NCCc1ccc(Oc2ccc(O)cc2)c(I)c1	10.1039/C5MD00490J
	CHEMBL1182312	18630	13	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Inverse agonist activity at human TAAR5 expressed in HEK293 cells by Alphascreen assayInverse agonist activity at human TAAR5 expressed in HEK293 cells by Alphascreen assay	ChEMBL	355	4	2	3	3.3	NCCc1ccc(Oc2ccc(O)cc2)c(I)c1	10.1039/C5MD00490J
	CHEMBL229288	18630	13	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Inverse agonist activity at human TAAR5 expressed in HEK293 cells by Alphascreen assayInverse agonist activity at human TAAR5 expressed in HEK293 cells by Alphascreen assay	ChEMBL	355	4	2	3	3.3	NCCc1ccc(Oc2ccc(O)cc2)c(I)c1	10.1039/C5MD00490J