GPCRdb

Ligand source activities (1 row/activity)

ChEMBL ID	Receptor	Species	Purchasable	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles

CHEMBL454791	calrl_human	Human	No	10.8	EC50	=	0.0	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CCRP-induced cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CCRP-induced cAMP production	627	6	3	5	3.5	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL207197	calrl_human	Human	Yes	10.6	EC50	=	0.0	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay	870	12	5	8	3.1	C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL207197	calrl_human	Human	Yes	10.6	EC50	=	0.0	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay	870	12	5	8	3.1	C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL450668	calrl_human	Human	Yes	10.5	EC50	=	0.0	Funct	Antagonist activity at human CGRP receptor in SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor in SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	645	6	3	6	3.6	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)NC(=O)N5CCC(CC5)N6CC7=C(C(=CC=C7)F)NC6=O)C=NN2
CHEMBL450668	calrl_human	Human	Yes	10.5	EC50	=	0.0	Funct	Antagonist activity at human CGRP receptor in SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor in SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	645	6	3	6	3.6	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)NC(=O)N5CCC(CC5)N6CC7=C(C(=CC=C7)F)NC6=O)C=NN2
CHEMBL2178422	calrl_human	Human	Yes	9.9	EC50	=	0.1	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 15 mins prior to CGRP challenge measured after 30 mins by HTRF assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 15 mins prior to CGRP challenge measured after 30 mins by HTRF assay	535	4	2	8	2.3	C1CC(C2=C(C=CC=N2)C(C1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL3288288	calrl_human	Human	No	9.8	EC50	=	0.2	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay	884	12	5	9	3.1	C1CN(CCC1N2C(=O)C3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL3288288	calrl_human	Human	No	9.8	EC50	=	0.2	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay	884	12	5	9	3.1	C1CN(CCC1N2C(=O)C3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL412994	calrl_human	Human	No	9.7	EC50	=	0.2	Funct	Agonist activity at human CGRP1 expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human CGRP1 expressed in HEK293 cells assessed as cAMP accumulation	3791	124	59	57	-15.7	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC4=CN=CN4)NC(=O)C(C(C)O)NC(=O)C(C(C)C)NC(=O)C(CS)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(CC(=O)O)NC(=O)C(CS)NC(=O)C(C)N
CHEMBL412994	calrl_human	Human	No	9.7	EC50	=	0.2	Funct	Agonist activity at human CGRP1 expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human CGRP1 expressed in HEK293 cells assessed as cAMP accumulation	3791	124	59	57	-15.7	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC4=CN=CN4)NC(=O)C(C(C)O)NC(=O)C(C(C)C)NC(=O)C(CS)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(CC(=O)O)NC(=O)C(CS)NC(=O)C(C)N
CHEMBL3288290	calrl_human	Human	No	7.0	EC50	=	100	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay	766	12	4	9	3.1	C1CN(CCC1N2C(=O)C3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC5=CC=CC=C5S4)C(=O)NC(CCCCN)C(=O)N6CCN(CC6)C7=CC=NC=C7
CHEMBL3288290	calrl_human	Human	No	7.0	EC50	=	100	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay	766	12	4	9	3.1	C1CN(CCC1N2C(=O)C3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC5=CC=CC=C5S4)C(=O)NC(CCCCN)C(=O)N6CCN(CC6)C7=CC=NC=C7
CHEMBL2059896	calrl_human	Human	No	7.9	EC50	=	12	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMPAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMP	614	5	2	5	4.7	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)CC(=O)NC7=CC=CC=C67
CHEMBL2059896	calrl_human	Human	No	7.9	EC50	=	12	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMPAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMP	614	5	2	5	4.7	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)CC(=O)NC7=CC=CC=C67
CHEMBL2059900	calrl_human	Human	No	7.9	EC50	=	13	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMPAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMP	627	6	2	6	4.5	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C(=O)NC(=N6)C7=CC=CC=C7
CHEMBL2059900	calrl_human	Human	No	7.9	EC50	=	13	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMPAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMP	627	6	2	6	4.5	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C(=O)NC(=N6)C7=CC=CC=C7
CHEMBL2059898	calrl_human	Human	No	6.9	EC50	=	130	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMPAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMP	614	5	2	5	4.8	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)CNC(=O)C7=CC=CC=C67
CHEMBL2059898	calrl_human	Human	No	6.9	EC50	=	130	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMPAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMP	614	5	2	5	4.8	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)CNC(=O)C7=CC=CC=C67
CHEMBL2059897	calrl_human	Human	No	7.8	EC50	=	15	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMPAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMP	614	5	2	5	4.4	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C7=CC=CC=C7CC(=O)N6
CHEMBL2059897	calrl_human	Human	No	7.8	EC50	=	15	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMPAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMP	614	5	2	5	4.4	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C7=CC=CC=C7CC(=O)N6
CHEMBL2059906	calrl_human	Human	No	8.5	EC50	=	3	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMPAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMP	615	5	3	5	4.1	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C7=CC=CC=C7NC(=O)N6
CHEMBL2059906	calrl_human	Human	No	8.5	EC50	=	3	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMPAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMP	615	5	3	5	4.1	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C7=CC=CC=C7NC(=O)N6
CHEMBL2059905	calrl_human	Human	No	7.5	EC50	=	31	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMPAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMP	616	5	2	6	4.7	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C7=CC=CC=C7NC(=O)O6
CHEMBL2059905	calrl_human	Human	No	7.5	EC50	=	31	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMPAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated formation of cyclic AMP	616	5	2	6	4.7	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C7=CC=CC=C7NC(=O)O6
CHEMBL3288289	calrl_human	Human	No	7.0	EC50	=	96	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay	752	12	4	8	3.2	C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC5=CC=CC=C5S4)C(=O)NC(CCCCN)C(=O)N6CCN(CC6)C7=CC=NC=C7
CHEMBL3288289	calrl_human	Human	No	7.0	EC50	=	96	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay	752	12	4	8	3.2	C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC5=CC=CC=C5S4)C(=O)NC(CCCCN)C(=O)N6CCN(CC6)C7=CC=NC=C7
CHEMBL452966	calrl_human	Human	No	11.0	IC50	=	0.0	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	628	7	2	6	4.1	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL452966	calrl_human	Human	No	11.0	IC50	=	0.0	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	628	7	2	6	4.1	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL508453	calrl_human	Human	No	11.0	IC50	=	0.0	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	646	7	2	7	4.2	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)OC(=O)N5CCC(CC5)N6CC7=C(C(=CC=C7)F)NC6=O)C=NN2
CHEMBL508453	calrl_human	Human	No	11.0	IC50	=	0.0	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	646	7	2	7	4.2	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)OC(=O)N5CCC(CC5)N6CC7=C(C(=CC=C7)F)NC6=O)C=NN2
CHEMBL508215	calrl_human	Human	No	10.8	IC50	=	0.0	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	625	7	2	6	4.7	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL508215	calrl_human	Human	No	10.8	IC50	=	0.0	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	625	7	2	6	4.7	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2018517	calrl_human	Human	No	10.7	IC50	=	0.0	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	626	7	2	5	3.5	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2018517	calrl_human	Human	No	10.7	IC50	=	0.0	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	626	7	2	5	3.5	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2022601	calrl_human	Human	No	10.7	IC50	=	0.0	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	608	8	2	6	4.3	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCCCC4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL447297	calrl_human	Human	No	10.7	IC50	=	0.0	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	625	7	2	6	4.9	CC1=C2C(=CC(=C1)CC(C(=O)N3CCN(CC3)C4CCCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL207197	calrl_human	Human	Yes	10.7	IC50	=	0.0	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	870	12	5	8	3.1	C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL2022601	calrl_human	Human	No	10.7	IC50	=	0.0	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	608	8	2	6	4.3	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCCCC4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL447297	calrl_human	Human	No	10.7	IC50	=	0.0	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	625	7	2	6	4.9	CC1=C2C(=CC(=C1)CC(C(=O)N3CCN(CC3)C4CCCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL207197	calrl_human	Human	Yes	10.7	IC50	=	0.0	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	870	12	5	8	3.1	C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL451164	calrl_human	Human	No	10.7	IC50	=	0.0	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	646	7	2	7	4.2	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)OC(=O)N5CCC(CC5)N6CC7=C(C=C(C=C7)F)NC6=O)C=NN2
CHEMBL451164	calrl_human	Human	No	10.7	IC50	=	0.0	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	646	7	2	7	4.2	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)OC(=O)N5CCC(CC5)N6CC7=C(C=C(C=C7)F)NC6=O)C=NN2
CHEMBL450668	calrl_human	Human	Yes	10.6	IC50	=	0.0	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	645	6	3	6	3.6	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)NC(=O)N5CCC(CC5)N6CC7=C(C(=CC=C7)F)NC6=O)C=NN2
CHEMBL197529	calrl_human	Human	No	10.5	IC50	=	0.0	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	870	12	5	8	3.1	C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL207197	calrl_human	Human	Yes	10.5	IC50	=	0.0	Funct	Antagonist activity against human CGRP receptorAntagonist activity against human CGRP receptor	870	12	5	8	3.1	C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL197529	calrl_human	Human	No	10.5	IC50	=	0.0	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	870	12	5	8	3.1	C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL207197	calrl_human	Human	Yes	10.5	IC50	=	0.0	Funct	Antagonist activity against human CGRP receptorAntagonist activity against human CGRP receptor	870	12	5	8	3.1	C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL2022606	calrl_human	Human	No	10.4	IC50	=	0.0	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	619	8	2	6	5.3	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCCCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2022606	calrl_human	Human	No	10.4	IC50	=	0.0	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	619	8	2	6	5.3	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCCCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2369459	calrl_human	Human	No	10.4	IC50	=	0.0	Funct	Displacement of radiolabeled CGRPalpha from human CGRP receptorDisplacement of radiolabeled CGRPalpha from human CGRP receptor	3789	110	55	57	-15.4	CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)C(C)O)CC(=O)O)NC(=O)C(C)N)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC2=CNC=N2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(C(C)C)C(=O)N4CCCC4C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC5=CC=CC=C5)C(=O)N)C(C)O
CHEMBL2369459	calrl_human	Human	No	10.4	IC50	=	0.0	Funct	Displacement of radiolabeled CGRPalpha from human CGRP receptorDisplacement of radiolabeled CGRPalpha from human CGRP receptor	3789	110	55	57	-15.4	CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)C(C)O)CC(=O)O)NC(=O)C(C)N)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC2=CNC=N2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(C(C)C)C(=O)N4CCCC4C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC5=CC=CC=C5)C(=O)N)C(C)O
CHEMBL501603	calrl_human	Human	No	10.4	IC50	=	0.0	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	625	6	2	6	4.4	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC4(CCN(CC4)C)CC3)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL501603	calrl_human	Human	No	10.4	IC50	=	0.0	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	625	6	2	6	4.4	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC4(CCN(CC4)C)CC3)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2018507	calrl_human	Human	No	10.3	IC50	=	0.0	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	638	8	2	5	3.8	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4C=C(NC4=O)C5=CC=CC=C5)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2018507	calrl_human	Human	No	10.3	IC50	=	0.0	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	638	8	2	5	3.8	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4C=C(NC4=O)C5=CC=CC=C5)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL408415	calrl_human	Human	No	10.3	IC50	=	0.1	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	882	13	5	8	3.4	C1CN(CCC1N2C=C(NC2=O)C3=CC=CC=C3)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL408415	calrl_human	Human	No	10.3	IC50	=	0.1	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	882	13	5	8	3.4	C1CN(CCC1N2C=C(NC2=O)C3=CC=CC=C3)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL499488	calrl_human	Human	No	10.3	IC50	=	0.1	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	623	7	2	6	4.6	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCC=CC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL499488	calrl_human	Human	No	10.3	IC50	=	0.1	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	623	7	2	6	4.6	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCC=CC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL452686	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	643	7	2	7	4.8	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)OC(=O)N5CCC(CC5)C6=CC7=C(C(=CC=C7)F)NC6=O)C=NN2
CHEMBL452686	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	643	7	2	7	4.8	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)OC(=O)N5CCC(CC5)C6=CC7=C(C(=CC=C7)F)NC6=O)C=NN2
CHEMBL197529	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Affinity against calcitonin gene related peptide receptor (1 uM) in marmoset tissue homogenates using [125I]CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against calcitonin gene related peptide receptor (1 uM) in marmoset tissue homogenates using [125I]CGRP as radioligand after 180 minutes of incubation at pH 7.40	870	12	5	8	3.1	C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL2018517	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	626	7	2	5	3.5	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL197529	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Affinity against calcitonin gene related peptide receptor (1 uM) in marmoset tissue homogenates using [125I]CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against calcitonin gene related peptide receptor (1 uM) in marmoset tissue homogenates using [125I]CGRP as radioligand after 180 minutes of incubation at pH 7.40	870	12	5	8	3.1	C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL2018517	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	626	7	2	5	3.5	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL508349	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	620	7	2	7	3.8	CC1=C2C(=CC(=C1)CC(C(=O)N3CCN(CC3)C4=CC=NC=C4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL508349	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	620	7	2	7	3.8	CC1=C2C(=CC(=C1)CC(C(=O)N3CCN(CC3)C4=CC=NC=C4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2023189	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	613	7	2	6	4.7	CC1=C2C(=CC(=C1)CC(C3=NC(=CC(=C3)C(=O)N(C)C)Cl)OC(=O)N4CCC(CC4)C5=CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2023189	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	613	7	2	6	4.7	CC1=C2C(=CC(=C1)CC(C3=NC(=CC(=C3)C(=O)N(C)C)Cl)OC(=O)N4CCC(CC4)C5=CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2018504	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	626	7	2	5	3.5	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2018504	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	626	7	2	5	3.5	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL502243	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	640	8	2	6	4.4	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)OC(=O)N5CCC(CC5)N6C=C(NC6=O)C7=CC=CC=C7)C=NN2
CHEMBL502243	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	640	8	2	6	4.4	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)OC(=O)N5CCC(CC5)N6C=C(NC6=O)C7=CC=CC=C7)C=NN2
CHEMBL2023191	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	603	7	2	7	3.3	CC1=C2C(=CC(=C1)CC(C3=NC(=CC(=C3)C(=O)N(C)C)Cl)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6)C=NN2
CHEMBL2023191	calrl_human	Human	No	10.2	IC50	=	0.1	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	603	7	2	7	3.3	CC1=C2C(=CC(=C1)CC(C3=NC(=CC(=C3)C(=O)N(C)C)Cl)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6)C=NN2
CHEMBL2018504	calrl_human	Human	No	10.1	IC50	=	0.1	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	626	7	2	5	3.5	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2018504	calrl_human	Human	No	10.1	IC50	=	0.1	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	626	7	2	5	3.5	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL1092882	calrl_human	Human	No	10.1	IC50	=	0.1	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	489	2	2	5	1.7	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C5C(=C2)C=CC(=N5)CN6C7=C8C(=CC=C7)NC(=O)CN8C6=O
CHEMBL1092882	calrl_human	Human	No	10.1	IC50	=	0.1	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	489	2	2	5	1.7	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C5C(=C2)C=CC(=N5)CN6C7=C8C(=CC=C7)NC(=O)CN8C6=O
CHEMBL2023189	calrl_human	Human	No	10.1	IC50	=	0.1	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	613	7	2	6	4.7	CC1=C2C(=CC(=C1)CC(C3=NC(=CC(=C3)C(=O)N(C)C)Cl)OC(=O)N4CCC(CC4)C5=CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2023189	calrl_human	Human	No	10.1	IC50	=	0.1	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	613	7	2	6	4.7	CC1=C2C(=CC(=C1)CC(C3=NC(=CC(=C3)C(=O)N(C)C)Cl)OC(=O)N4CCC(CC4)C5=CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2430167	calrl_human	Human	No	10.1	IC50	=	0.1	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	638	7	3	5	4.1	CC1=C2C(=CC(=C1)CC(C3=NC=CN3CC4=CC(=NC(=C4)Cl)C)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2018519	calrl_human	Human	No	10.1	IC50	=	0.1	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	644	7	2	6	3.6	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=C(C(=CC=C5)F)NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2018519	calrl_human	Human	No	10.1	IC50	=	0.1	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	644	7	2	6	3.6	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=C(C(=CC=C5)F)NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2018505	calrl_human	Human	No	10.1	IC50	=	0.1	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	644	7	2	6	3.6	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=C(C(=CC=C5)F)NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2018505	calrl_human	Human	No	10.1	IC50	=	0.1	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	644	7	2	6	3.6	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=C(C(=CC=C5)F)NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2023190	calrl_human	Human	No	10.0	IC50	=	0.1	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	630	7	2	6	4.5	CC1=C2C(=CC(=C1)CC(C3=NC(=CC(=C3)C(=O)N(C)C)Cl)OC(=O)N4CCC(CC4)N5CCC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2023190	calrl_human	Human	No	10.0	IC50	=	0.1	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	630	7	2	6	4.5	CC1=C2C(=CC(=C1)CC(C3=NC(=CC(=C3)C(=O)N(C)C)Cl)OC(=O)N4CCC(CC4)N5CCC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2022606	calrl_human	Human	No	10.0	IC50	=	0.1	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	619	8	2	6	5.3	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCCCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2022606	calrl_human	Human	No	10.0	IC50	=	0.1	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	619	8	2	6	5.3	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCCCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2431248	calrl_human	Human	No	10.0	IC50	=	0.1	Funct	Antagonist activity at CGRP receptor (unknown origin) by cell based cAMP assayAntagonist activity at CGRP receptor (unknown origin) by cell based cAMP assay	586	4	2	7	3.4	CC1(CN(C2(CCCC2)C(=O)N1CC(=O)NC3=CC4=C(CC5(C4)C6=C(NC5=O)N=CC=C6)C=C3)C)C7=CC(=CC(=C7)F)F
CHEMBL2022600	calrl_human	Human	No	10.0	IC50	=	0.1	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	622	7	2	6	3.9	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)C(=O)N4CCCCC4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2022600	calrl_human	Human	No	10.0	IC50	=	0.1	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	622	7	2	6	3.9	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)C(=O)N4CCCCC4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2022603	calrl_human	Human	No	10.0	IC50	=	0.1	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	605	8	2	6	4.9	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2022601	calrl_human	Human	No	10.0	IC50	=	0.1	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	608	8	2	6	4.3	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCCCC4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2022603	calrl_human	Human	No	10.0	IC50	=	0.1	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	605	8	2	6	4.9	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2022601	calrl_human	Human	No	10.0	IC50	=	0.1	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	608	8	2	6	4.3	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCCCC4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2018508	calrl_human	Human	No	9.9	IC50	=	0.1	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	623	7	2	5	4.2	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)C4=CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL585568	calrl_human	Human	No	9.9	IC50	=	0.1	Funct	Antagonist activity at human cloned CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP production	531	4	2	6	3.7	CC1(CCC(N(C1=O)CC(=O)NC2=CC3=C(CC4(C3)C5=C(NC4=O)N=CC=C5)C=C2)C6=C(C=CC=C6F)F)C
CHEMBL2018508	calrl_human	Human	No	9.9	IC50	=	0.1	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	623	7	2	5	4.2	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)C4=CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL585568	calrl_human	Human	No	9.9	IC50	=	0.1	Funct	Antagonist activity at human cloned CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP production	531	4	2	6	3.7	CC1(CCC(N(C1=O)CC(=O)NC2=CC3=C(CC4(C3)C5=C(NC4=O)N=CC=C5)C=C2)C6=C(C=CC=C6F)F)C
CHEMBL507893	calrl_human	Human	No	9.9	IC50	=	0.1	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	637	7	2	7	5.0	CC1=C2C(=CC(=C1)CC(C(=O)N3CCN(CC3)C4=CC=C(C=C4)F)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2430169	calrl_human	Human	No	9.9	IC50	=	0.1	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	604	7	3	5	3.1	CC1=C2C(=CC(=C1)CC(C3=NC=CN3CC4=CC(=NC=C4)C)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL507893	calrl_human	Human	No	9.9	IC50	=	0.1	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	637	7	2	7	5.0	CC1=C2C(=CC(=C1)CC(C(=O)N3CCN(CC3)C4=CC=C(C=C4)F)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2018507	calrl_human	Human	No	9.8	IC50	=	0.2	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	638	8	2	5	3.8	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4C=C(NC4=O)C5=CC=CC=C5)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2018507	calrl_human	Human	No	9.8	IC50	=	0.2	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	638	8	2	5	3.8	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4C=C(NC4=O)C5=CC=CC=C5)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2022603	calrl_human	Human	No	9.8	IC50	=	0.2	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	605	8	2	6	4.9	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2022603	calrl_human	Human	No	9.8	IC50	=	0.2	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	605	8	2	6	4.9	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL499810	calrl_human	Human	No	9.7	IC50	=	0.2	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	609	7	1	6	5.5	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7C=N6)C=NN2
CHEMBL2018505	calrl_human	Human	No	9.7	IC50	=	0.2	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	644	7	2	6	3.6	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=C(C(=CC=C5)F)NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL499810	calrl_human	Human	No	9.8	IC50	=	0.2	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	609	7	1	6	5.5	CC1=C2C(=CC(=C1)CC(C(=O)N3CCC(CC3)N4CCCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7C=N6)C=NN2
CHEMBL2018505	calrl_human	Human	No	9.8	IC50	=	0.2	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	644	7	2	6	3.6	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=C(C(=CC=C5)F)NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2430177	calrl_human	Human	No	9.7	IC50	=	0.2	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	645	8	3	4	5.4	CC1=C2C(=CC(=C1)CC(C3=NC=CN3CC4=CC=C(C=C4)C(C)(C)C)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL382469	calrl_human	Human	No	9.7	IC50	=	0.2	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	856	12	5	8	3.2	C1CN(CCC1N2C3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL2018519	calrl_human	Human	No	9.7	IC50	=	0.2	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	644	7	2	6	3.6	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=C(C(=CC=C5)F)NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL382469	calrl_human	Human	No	9.7	IC50	=	0.2	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	856	12	5	8	3.2	C1CN(CCC1N2C3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL2018519	calrl_human	Human	No	9.7	IC50	=	0.2	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	644	7	2	6	3.6	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=C(C(=CC=C5)F)NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL1770729	calrl_human	Human	No	9.7	IC50	=	0.2	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	593	3	2	8	2.4	CC1(CCCO1)C2=CN=C3N2CC(CCC3NC(=O)N4CCC5(CC4)C6=C(NC(=O)O5)N=CC=C6)C7=C(C(=CC=C7)F)F
CHEMBL2024603	calrl_human	Human	No	9.7	IC50	=	0.2	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	539	7	2	6	3.0	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)C=O)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL1770729	calrl_human	Human	No	9.7	IC50	=	0.2	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	593	3	2	8	2.4	CC1(CCCO1)C2=CN=C3N2CC(CCC3NC(=O)N4CCC5(CC4)C6=C(NC(=O)O5)N=CC=C6)C7=C(C(=CC=C7)F)F
CHEMBL2024603	calrl_human	Human	No	9.7	IC50	=	0.2	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	539	7	2	6	3.0	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)C=O)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2063115	calrl_human	Human	No	9.7	IC50	=	0.2	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	520	4	1	7	3.7	C1CC(C2=C(CC1C3=C(C(=CC=C3)F)F)C=CC=N2)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL2063115	calrl_human	Human	No	9.7	IC50	=	0.2	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	520	4	1	7	3.7	C1CC(C2=C(CC1C3=C(C(=CC=C3)F)F)C=CC=N2)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL2430166	calrl_human	Human	No	9.7	IC50	=	0.2	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	634	7	2	6	4.8	CC1=C2C(=CC(=C1)CC(C3=NC=C4N3CCN(C4)C5CCCCC5)OC(=O)N6CCC(CC6)C7=CC8=CC=CC=C8NC7=O)C=NN2
CHEMBL2035983	calrl_human	Human	No	9.6	IC50	=	0.2	Funct	Antagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the absence of human serumAntagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the absence of human serum	573	4	3	8	1.9	CC1(CNC2(CCCC2)C(=O)N1CC(=O)NC3=CN=C4CC5(CC4=C3)C6=C(NC5=O)N=CC=C6)C7=CC(=CC(=C7)F)F
CHEMBL2035983	calrl_human	Human	No	9.6	IC50	=	0.2	Funct	Antagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the absence of human serumAntagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the absence of human serum	573	4	3	8	1.9	CC1(CNC2(CCCC2)C(=O)N1CC(=O)NC3=CN=C4CC5(CC4=C3)C6=C(NC5=O)N=CC=C6)C7=CC(=CC(=C7)F)F
CHEMBL1770724	calrl_human	Human	No	9.6	IC50	=	0.2	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	581	4	2	8	2.3	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL2022604	calrl_human	Human	No	9.6	IC50	=	0.2	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	591	8	2	6	4.6	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2022609	calrl_human	Human	No	9.6	IC50	=	0.2	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	587	7	2	5	5.2	CC1=CC(=CC2=C(NN=C12)C3=CC=CC=C3)CC(C4=CC=CC=N4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O
CHEMBL1770724	calrl_human	Human	No	9.6	IC50	=	0.2	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	581	4	2	8	2.3	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL2022604	calrl_human	Human	No	9.6	IC50	=	0.2	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	591	8	2	6	4.6	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2022609	calrl_human	Human	No	9.6	IC50	=	0.2	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	587	7	2	5	5.2	CC1=CC(=CC2=C(NN=C12)C3=CC=CC=C3)CC(C4=CC=CC=N4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O
CHEMBL1770728	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	609	6	2	8	3.4	CCC(CC)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL1770728	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	609	6	2	8	3.4	CCC(CC)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL2430165	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	642	8	2	6	4.5	CC1=C2C(=CC(=C1)CC(C3=NC=C4N3CCN(C4)CC5=CC=CC=C5)OC(=O)N6CCC(CC6)C7=CC8=CC=CC=C8NC7=O)C=NN2
CHEMBL2022599	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	588	7	2	6	4.1	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)C4=CC=NC=C4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2022599	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	588	7	2	6	4.1	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)C4=CC=NC=C4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2024603	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	539	7	2	6	3.0	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)C=O)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL512773	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay	480	3	3	5	0.8	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C(C=C2)NC(=O)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL512773	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	480	3	3	5	0.8	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C(C=C2)NC(=O)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL512773	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production	480	3	3	5	0.8	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C(C=C2)NC(=O)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL2023188	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	613	7	2	6	4.7	CC1=C2C(=CC(=C1)CC(C3=NC(=CC(=C3)C(=O)N(C)C)Cl)OC(=O)N4CCC(CC4)C5=CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2022600	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	622	7	2	6	3.9	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)C(=O)N4CCCCC4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2024603	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	539	7	2	6	3.0	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)C=O)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL512773	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay	480	3	3	5	0.8	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C(C=C2)NC(=O)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL512773	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	480	3	3	5	0.8	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C(C=C2)NC(=O)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL512773	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production	480	3	3	5	0.8	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C(C=C2)NC(=O)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL2023188	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	613	7	2	6	4.7	CC1=C2C(=CC(=C1)CC(C3=NC(=CC(=C3)C(=O)N(C)C)Cl)OC(=O)N4CCC(CC4)C5=CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2022600	calrl_human	Human	No	9.6	IC50	=	0.3	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	622	7	2	6	3.9	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)C(=O)N4CCCCC4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2018508	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	623	7	2	5	4.2	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)C4=CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL3114495	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay	693	9	1	7	5.7	CC(C)N1CCN(CC1)C2=C(C=CC=C2F)C3N(C(=O)C(S3)CC(=O)N4CCC(CC4)N5CCC6=CC=CC=C6NC5=O)CCC(C)(C)C
CHEMBL2018508	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	623	7	2	5	4.2	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)C4=CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL1770715	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	580	5	2	7	2.2	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL1770715	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	580	5	2	7	2.2	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL1770726	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	595	5	2	8	2.7	CCOC(C)(C)C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL1770726	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	595	5	2	8	2.7	CCOC(C)(C)C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL2018503	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	613	6	2	6	3.7	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC4(CC3)C5=CC=CC=C5NC(=O)O4)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2022598	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	582	7	2	6	3.0	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)C(=O)N(C)C)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2022607	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	589	6	2	5	4.6	CC1=CC(=CC2=C(NN=C12)Br)CC(C3=CC=CC=N3)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL2018503	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	613	6	2	6	3.7	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC4(CC3)C5=CC=CC=C5NC(=O)O4)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2022598	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	582	7	2	6	3.0	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)C(=O)N(C)C)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2022607	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	589	6	2	5	4.6	CC1=CC(=CC2=C(NN=C12)Br)CC(C3=CC=CC=N3)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL2023188	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	613	7	2	6	4.7	CC1=C2C(=CC(=C1)CC(C3=NC(=CC(=C3)C(=O)N(C)C)Cl)OC(=O)N4CCC(CC4)C5=CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2035983	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Antagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the presence of 50% human serumAntagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the presence of 50% human serum	573	4	3	8	1.9	CC1(CNC2(CCCC2)C(=O)N1CC(=O)NC3=CN=C4CC5(CC4=C3)C6=C(NC5=O)N=CC=C6)C7=CC(=CC(=C7)F)F
CHEMBL2018506	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	612	6	3	5	3.1	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC4(CC3)C5=CC=CC=C5NC(=O)N4)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2023188	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	613	7	2	6	4.7	CC1=C2C(=CC(=C1)CC(C3=NC(=CC(=C3)C(=O)N(C)C)Cl)OC(=O)N4CCC(CC4)C5=CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2035983	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Antagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the presence of 50% human serumAntagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the presence of 50% human serum	573	4	3	8	1.9	CC1(CNC2(CCCC2)C(=O)N1CC(=O)NC3=CN=C4CC5(CC4=C3)C6=C(NC5=O)N=CC=C6)C7=CC(=CC(=C7)F)F
CHEMBL2018506	calrl_human	Human	No	9.5	IC50	=	0.3	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	612	6	3	5	3.1	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC4(CC3)C5=CC=CC=C5NC(=O)N4)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2018506	calrl_human	Human	No	9.5	IC50	=	0.4	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	612	6	3	5	3.1	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC4(CC3)C5=CC=CC=C5NC(=O)N4)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2018506	calrl_human	Human	No	9.5	IC50	=	0.4	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	612	6	3	5	3.1	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC4(CC3)C5=CC=CC=C5NC(=O)N4)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL1770557	calrl_human	Human	No	9.4	IC50	=	0.4	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	590	4	2	9	3.3	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL1770557	calrl_human	Human	No	9.4	IC50	=	0.4	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	590	4	2	9	3.3	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL2430174	calrl_human	Human	No	9.4	IC50	=	0.4	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	621	7	3	5	4.3	CC1=C2C(=CC(=C1)CC(C3=NC=C(N3CC4=CC(=CC=C4)F)C)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2024595	calrl_human	Human	No	9.4	IC50	=	0.4	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	589	6	2	5	4.6	CC1=C2C(=CC(=C1)CC(C3=NC(=CC=C3)Br)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2024595	calrl_human	Human	No	9.4	IC50	=	0.4	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	589	6	2	5	4.6	CC1=C2C(=CC(=C1)CC(C3=NC(=CC=C3)Br)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2022608	calrl_human	Human	No	9.4	IC50	=	0.4	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	545	6	2	5	4.5	CC1=CC(=CC2=C(NN=C12)Cl)CC(C3=CC=CC=N3)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL2431248	calrl_human	Human	No	9.4	IC50	=	0.4	Funct	Antagonist activity at CGRP receptor (unknown origin) by cell based cAMP assay in presence of human serumAntagonist activity at CGRP receptor (unknown origin) by cell based cAMP assay in presence of human serum	586	4	2	7	3.4	CC1(CN(C2(CCCC2)C(=O)N1CC(=O)NC3=CC4=C(CC5(C4)C6=C(NC5=O)N=CC=C6)C=C3)C)C7=CC(=CC(=C7)F)F
CHEMBL2430178	calrl_human	Human	No	9.4	IC50	=	0.4	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	625	7	3	6	4.0	CC1=C2C(=CC(=C1)CC(C3=NC=CN3CC4=CC(=CC(=C4)F)F)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2430176	calrl_human	Human	No	9.4	IC50	=	0.4	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	704	7	3	6	5.0	CC1=C2C(=CC(=C1)CC(C3=NC(=CN3CC4=CC(=CC(=C4)F)F)Br)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2022608	calrl_human	Human	No	9.4	IC50	=	0.4	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	545	6	2	5	4.5	CC1=CC(=CC2=C(NN=C12)Cl)CC(C3=CC=CC=N3)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL1770720	calrl_human	Human	No	9.4	IC50	=	0.4	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	591	3	2	10	3.4	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC5(CC4)C6=C(NC(=O)O5)N=CC=C6
CHEMBL1770720	calrl_human	Human	No	9.4	IC50	=	0.4	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	591	3	2	10	3.4	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC5(CC4)C6=C(NC(=O)O5)N=CC=C6
CHEMBL1770728	calrl_human	Human	No	9.4	IC50	=	0.4	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	609	6	2	8	3.4	CCC(CC)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL1770728	calrl_human	Human	No	9.4	IC50	=	0.4	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	609	6	2	8	3.4	CCC(CC)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL2430170	calrl_human	Human	No	9.4	IC50	=	0.4	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	590	7	3	5	2.7	CC1=C2C(=CC(=C1)CC(C3=NC=CN3CC4=CN=CC=C4)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2024595	calrl_human	Human	No	9.3	IC50	=	0.5	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	589	6	2	5	4.6	CC1=C2C(=CC(=C1)CC(C3=NC(=CC=C3)Br)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2024599	calrl_human	Human	No	9.3	IC50	=	0.5	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	561	6	2	5	4.8	CC1=C2C(=CC(=C1)CC(C3=CC4=CC=CC=C4C=N3)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2024595	calrl_human	Human	No	9.3	IC50	=	0.5	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	589	6	2	5	4.6	CC1=C2C(=CC(=C1)CC(C3=NC(=CC=C3)Br)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2024599	calrl_human	Human	No	9.3	IC50	=	0.5	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	561	6	2	5	4.8	CC1=C2C(=CC(=C1)CC(C3=CC4=CC=CC=C4C=N3)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2024594	calrl_human	Human	No	9.3	IC50	=	0.5	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	589	5	3	4	4.0	CC1=C2C(=CC(=C1)CC(C3=NC(=CC=C3)Br)NC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2024594	calrl_human	Human	No	9.3	IC50	=	0.5	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	589	5	3	4	4.0	CC1=C2C(=CC(=C1)CC(C3=NC(=CC=C3)Br)NC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL525571	calrl_human	Human	No	9.3	IC50	=	0.5	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig vas deferens membrane preparation.Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig vas deferens membrane preparation.	3126	104	47	44	-9.3	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC4=CN=CN4)NC(=O)C(C(C)O)NC(=O)C(C(C)C)N
CHEMBL2369463	calrl_human	Human	No	9.3	IC50	=	0.5	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig vas deferens membrane preparation.Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig vas deferens membrane preparation.	3027	99	44	43	-10.8	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC4=CNC=N4)NC(=O)C(C(C)O)N
CHEMBL1089433	calrl_human	Human	No	9.3	IC50	=	0.5	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	488	2	2	5	3.1	CC12CC(=O)NC3=C1C(=CC=C3)N(C2)CC4=NC5=CC6=C(CC7(C6)C8=C(NC7=O)N=CC=C8)C=C5C=C4
CHEMBL1089433	calrl_human	Human	No	9.3	IC50	=	0.5	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	488	2	2	5	3.1	CC12CC(=O)NC3=C1C(=CC=C3)N(C2)CC4=NC5=CC6=C(CC7(C6)C8=C(NC7=O)N=CC=C8)C=C5C=C4
CHEMBL3114496	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay	707	9	1	7	5.8	CC(C)(C)CCN1C(SC(C1=O)CC(=O)N2CCC(CC2)N3CCC4=CC=CC=C4NC3=O)C5=C(C(=CC=C5)F)N6CCN(CC6)C(C)(C)C
CHEMBL525571	calrl_rat	Rat	No	9.2	IC50	=	0.6	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type alpha receptor binding sites in rat brain membraneBinding affinity against [125I]-hCalcitonin gene-related peptide type alpha receptor binding sites in rat brain membrane	3126	104	47	44	-9.3	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC4=CN=CN4)NC(=O)C(C(C)O)NC(=O)C(C(C)C)N
CHEMBL1770723	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	553	4	2	8	1.7	COCC1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL1770715	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	580	5	2	7	2.2	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL562069	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay	463	3	3	4	1.8	C1C2=CN(C3=C2C(=CC=C3)NC1=O)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
CHEMBL1770723	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	553	4	2	8	1.7	COCC1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL1770715	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	580	5	2	7	2.2	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL562069	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay	463	3	3	4	1.8	C1C2=CN(C3=C2C(=CC=C3)NC1=O)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
CHEMBL1770568	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	550	4	2	6	3.1	CC(C)C1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL512773	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serumAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serum	480	3	3	5	0.8	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C(C=C2)NC(=O)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL512773	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serumAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serum	480	3	3	5	0.8	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C(C=C2)NC(=O)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL570933	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at human cloned CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP production	517	3	3	6	1.1	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C5C(=C2)C=CC(=N5)CN6C7=CC=CC8=C7C(C6=O)(CC(=O)N8)CN
CHEMBL512773	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	480	3	3	5	0.8	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C(C=C2)NC(=O)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL1770568	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	550	4	2	6	3.1	CC(C)C1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL512773	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serumAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serum	480	3	3	5	0.8	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C(C=C2)NC(=O)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL512773	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serumAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serum	480	3	3	5	0.8	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C(C=C2)NC(=O)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL570933	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at human cloned CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP production	517	3	3	6	1.1	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C5C(=C2)C=CC(=N5)CN6C7=CC=CC8=C7C(C6=O)(CC(=O)N8)CN
CHEMBL512773	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	480	3	3	5	0.8	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C(C=C2)NC(=O)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL1770714	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	552	5	2	7	1.6	COCC1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL1770724	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	581	4	2	8	2.3	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL2024599	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	561	6	2	5	4.8	CC1=C2C(=CC(=C1)CC(C3=CC4=CC=CC=C4C=N3)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL1770714	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	552	5	2	7	1.6	COCC1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL1770724	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	581	4	2	8	2.3	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL2024599	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	561	6	2	5	4.8	CC1=C2C(=CC(=C1)CC(C3=CC4=CC=CC=C4C=N3)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2430179	calrl_human	Human	No	9.2	IC50	=	0.6	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	607	7	3	5	3.9	CC1=C2C(=CC(=C1)CC(C3=NC=CN3CC4=CC(=CC=C4)F)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL1770727	calrl_human	Human	No	9.2	IC50	=	0.7	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	649	5	2	11	3.4	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)OCC(F)(F)F
CHEMBL1770727	calrl_human	Human	No	9.2	IC50	=	0.7	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	649	5	2	11	3.4	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)OCC(F)(F)F
CHEMBL1092208	calrl_human	Human	No	9.2	IC50	=	0.7	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	502	3	2	5	3.4	CCC12CC(=O)NC3=C1C(=CC=C3)N(C2)CC4=NC5=CC6=C(CC7(C6)C8=C(NC7=O)N=CC=C8)C=C5C=C4
CHEMBL1092208	calrl_human	Human	No	9.2	IC50	=	0.7	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	502	3	2	5	3.4	CCC12CC(=O)NC3=C1C(=CC=C3)N(C2)CC4=NC5=CC6=C(CC7(C6)C8=C(NC7=O)N=CC=C8)C=C5C=C4
CHEMBL2018503	calrl_human	Human	No	9.2	IC50	=	0.7	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	613	6	2	6	3.7	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC4(CC3)C5=CC=CC=C5NC(=O)O4)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2018503	calrl_human	Human	No	9.2	IC50	=	0.7	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	613	6	2	6	3.7	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC4(CC3)C5=CC=CC=C5NC(=O)O4)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL1770729	calrl_human	Human	No	9.1	IC50	=	0.8	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	593	3	2	8	2.4	CC1(CCCO1)C2=CN=C3N2CC(CCC3NC(=O)N4CCC5(CC4)C6=C(NC(=O)O5)N=CC=C6)C7=C(C(=CC=C7)F)F
CHEMBL1770729	calrl_human	Human	No	9.1	IC50	=	0.8	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	593	3	2	8	2.4	CC1(CCCO1)C2=CN=C3N2CC(CCC3NC(=O)N4CCC5(CC4)C6=C(NC(=O)O5)N=CC=C6)C7=C(C(=CC=C7)F)F
CHEMBL2430185	calrl_human	Human	No	9.1	IC50	=	0.8	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	589	7	3	4	3.8	CC1=C2C(=CC(=C1)CC(C3=NC=CN3CC4=CC=CC=C4)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL1770719	calrl_human	Human	No	9.1	IC50	=	0.8	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	565	4	2	7	2.0	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL2024594	calrl_human	Human	No	9.1	IC50	=	0.8	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	589	5	3	4	4.0	CC1=C2C(=CC(=C1)CC(C3=NC(=CC=C3)Br)NC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2024598	calrl_human	Human	No	9.1	IC50	=	0.8	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	560	5	3	4	4.3	CC1=C2C(=CC(=C1)CC(C3=CC4=CC=CC=C4C=N3)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL1770719	calrl_human	Human	No	9.1	IC50	=	0.8	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	565	4	2	7	2.0	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL2024594	calrl_human	Human	No	9.1	IC50	=	0.8	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	589	5	3	4	4.0	CC1=C2C(=CC(=C1)CC(C3=NC(=CC=C3)Br)NC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2024598	calrl_human	Human	No	9.1	IC50	=	0.8	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	560	5	3	4	4.3	CC1=C2C(=CC(=C1)CC(C3=CC4=CC=CC=C4C=N3)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL1770722	calrl_human	Human	No	9.1	IC50	=	0.8	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	592	3	2	11	2.9	C1CC(C2=NN=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC5(CC4)C6=C(NC(=O)O5)N=CC=C6
CHEMBL1770722	calrl_human	Human	No	9.1	IC50	=	0.8	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	592	3	2	11	2.9	C1CC(C2=NN=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC5(CC4)C6=C(NC(=O)O5)N=CC=C6
CHEMBL2430168	calrl_human	Human	No	9.1	IC50	=	0.8	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	590	7	3	5	2.7	CC1=C2C(=CC(=C1)CC(C3=NC=CN3CC4=CC=NC=C4)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL1770725	calrl_human	Human	No	9.1	IC50	=	0.9	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	567	3	3	8	1.8	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)O
CHEMBL1092837	calrl_human	Human	No	9.1	IC50	=	0.9	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	474	2	2	5	2.5	C1C2CN(C3=CC=CC(=C23)NC1=O)CC4=NC5=CC6=C(CC7(C6)C8=C(NC7=O)N=CC=C8)C=C5C=C4
CHEMBL1770725	calrl_human	Human	No	9.1	IC50	=	0.9	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	567	3	3	8	1.8	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)O
CHEMBL1092837	calrl_human	Human	No	9.1	IC50	=	0.9	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	474	2	2	5	2.5	C1C2CN(C3=CC=CC(=C23)NC1=O)CC4=NC5=CC6=C(CC7(C6)C8=C(NC7=O)N=CC=C8)C=C5C=C4
CHEMBL517467	calrl_human	Human	No	9.1	IC50	=	0.9	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production	539	5	2	5	2.0	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N(C)C)CC(=O)NC3=CC4=C(CC5(C4)C6=C(NC5=O)N=CC=C6)C=C3)C
CHEMBL517467	calrl_human	Human	No	9.1	IC50	=	0.9	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production	539	5	2	5	2.0	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N(C)C)CC(=O)NC3=CC4=C(CC5(C4)C6=C(NC5=O)N=CC=C6)C=C3)C
CHEMBL1162991	calrl_human	Human	No	9.1	IC50	=	0.9	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay	489	3	2	5	0.4	CC1=CC2=C3C(=C1)N(C(=O)CN3C(=O)N2CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4)C
CHEMBL466192	calrl_human	Human	No	9.1	IC50	=	0.9	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production	474	3	3	5	0.2	CC1=CC2=C3C(=C1)NC(=O)CN3C(=O)N2CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4
CHEMBL2430182	calrl_human	Human	No	9.1	IC50	=	0.9	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	603	8	3	4	4.1	CC1=C2C(=CC(=C1)CC(C3=NC=CN3CCC4=CC=CC=C4)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL1162991	calrl_human	Human	No	9.1	IC50	=	0.9	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay	489	3	2	5	0.4	CC1=CC2=C3C(=C1)N(C(=O)CN3C(=O)N2CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4)C
CHEMBL466192	calrl_human	Human	No	9.1	IC50	=	0.9	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production	474	3	3	5	0.2	CC1=CC2=C3C(=C1)NC(=O)CN3C(=O)N2CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4
CHEMBL2369463	calrl_rat	Rat	No	9.1	IC50	=	0.9	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type alpha receptor binding sites in rat brain membraneBinding affinity against [125I]-hCalcitonin gene-related peptide type alpha receptor binding sites in rat brain membrane	3027	99	44	43	-10.8	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC4=CNC=N4)NC(=O)C(C(C)O)N
CHEMBL1770716	calrl_human	Human	No	9.0	IC50	=	0.9	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	575	3	2	9	3.1	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC5(CC4)C6=C(NC5=O)N=CC=C6
CHEMBL2024589	calrl_human	Human	No	9.0	IC50	=	0.9	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	537	7	2	5	2.8	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C6=NC=C(C=C6)C=O)C=NN2
CHEMBL1770716	calrl_human	Human	No	9.0	IC50	=	0.9	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	575	3	2	9	3.1	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC5(CC4)C6=C(NC5=O)N=CC=C6
CHEMBL2024589	calrl_human	Human	No	9.0	IC50	=	0.9	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	537	7	2	5	2.8	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C6=NC=C(C=C6)C=O)C=NN2
CHEMBL2430180	calrl_human	Human	No	9.0	IC50	=	1.0	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	607	7	3	5	3.9	CC1=C2C(=CC(=C1)CC(C3=NC=CN3CC4=CC=C(C=C4)F)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2024598	calrl_human	Human	No	9.0	IC50	=	1	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	560	5	3	4	4.3	CC1=C2C(=CC(=C1)CC(C3=CC4=CC=CC=C4C=N3)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL238276	calrl_human	Human	No	9.0	IC50	=	1	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	597	6	2	10	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CCOC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL2024598	calrl_human	Human	No	9.0	IC50	=	1	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	560	5	3	4	4.3	CC1=C2C(=CC(=C1)CC(C3=CC4=CC=CC=C4C=N3)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL3114676	calrl_human	Human	No	9.0	IC50	=	1	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay	707	9	1	7	5.8	CC(C)(C)CCN1C(SC(C1=O)CC(=O)N2CCC(CC2)N3CCC4=CC=CC=C4NC3=O)C5=C(C(=CC=C5)F)N6CCN(CC6)C(C)(C)C
CHEMBL238276	calrl_human	Human	No	9.0	IC50	=	1	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	597	6	2	10	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CCOC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL2024589	calrl_human	Human	No	9.0	IC50	=	1.1	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	537	7	2	5	2.8	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C6=NC=C(C=C6)C=O)C=NN2
CHEMBL2024589	calrl_human	Human	No	9.0	IC50	=	1.1	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	537	7	2	5	2.8	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C6=NC=C(C=C6)C=O)C=NN2
CHEMBL1090515	calrl_human	Human	No	8.9	IC50	=	1.2	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	503	2	1	5	1.9	CN1C(=O)CN2C3=C(C=CC=C31)N(C2=O)CC4=NC5=CC6=C(CC7(C6)C8=C(NC7=O)N=CC=C8)C=C5C=C4
CHEMBL2022605	calrl_human	Human	No	8.9	IC50	=	1.2	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	607	8	2	7	3.7	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCOCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL1090515	calrl_human	Human	No	8.9	IC50	=	1.2	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	503	2	1	5	1.9	CN1C(=O)CN2C3=C(C=CC=C31)N(C2=O)CC4=NC5=CC6=C(CC7(C6)C8=C(NC7=O)N=CC=C8)C=C5C=C4
CHEMBL2022605	calrl_human	Human	No	8.9	IC50	=	1.2	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	607	8	2	7	3.7	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CN4CCOCC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL1770722	calrl_human	Human	No	8.9	IC50	=	1.3	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	592	3	2	11	2.9	C1CC(C2=NN=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC5(CC4)C6=C(NC(=O)O5)N=CC=C6
CHEMBL2024590	calrl_human	Human	No	8.9	IC50	=	1.3	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	606	8	2	5	4.0	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C6=NC=C(C=C6)CN7CCCCC7)C=NN2
CHEMBL564487	calrl_human	Human	Yes	8.9	IC50	=	1.3	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay	480	3	3	5	2.2	CC12CC(=O)NC3=C1C(=CC=C3)N(C2)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
CHEMBL1089433	calrl_human	Human	No	8.9	IC50	=	1.3	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serumAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serum	488	2	2	5	3.1	CC12CC(=O)NC3=C1C(=CC=C3)N(C2)CC4=NC5=CC6=C(CC7(C6)C8=C(NC7=O)N=CC=C8)C=C5C=C4
CHEMBL2022610	calrl_human	Human	No	8.9	IC50	=	1.3	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	539	7	2	6	3.4	CC1=CC(=CC2=C(NN=C12)C=O)CC(C3=CC=CC=N3)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL1770722	calrl_human	Human	No	8.9	IC50	=	1.3	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	592	3	2	11	2.9	C1CC(C2=NN=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC5(CC4)C6=C(NC(=O)O5)N=CC=C6
CHEMBL2024590	calrl_human	Human	No	8.9	IC50	=	1.3	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	606	8	2	5	4.0	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C6=NC=C(C=C6)CN7CCCCC7)C=NN2
CHEMBL564487	calrl_human	Human	Yes	8.9	IC50	=	1.3	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay	480	3	3	5	2.2	CC12CC(=O)NC3=C1C(=CC=C3)N(C2)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
CHEMBL1089433	calrl_human	Human	No	8.9	IC50	=	1.3	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serumAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serum	488	2	2	5	3.1	CC12CC(=O)NC3=C1C(=CC=C3)N(C2)CC4=NC5=CC6=C(CC7(C6)C8=C(NC7=O)N=CC=C8)C=C5C=C4
CHEMBL2022610	calrl_human	Human	No	8.9	IC50	=	1.3	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	539	7	2	6	3.4	CC1=CC(=CC2=C(NN=C12)C=O)CC(C3=CC=CC=N3)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL1770717	calrl_human	Human	No	8.9	IC50	=	1.4	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	601	3	2	9	3.4	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)C4(CC4)C(F)(F)F)NC(=O)N5CCC6(CC5)C7=C(NC6=O)N=CC=C7
CHEMBL1770719	calrl_human	Human	No	8.9	IC50	=	1.4	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	565	4	2	7	2.0	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL2024596	calrl_human	Human	No	8.9	IC50	=	1.4	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	560	5	3	4	4.3	CC1=C2C(=CC(=C1)CC(C3=NC4=CC=CC=C4C=C3)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2024597	calrl_human	Human	No	8.9	IC50	=	1.4	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	561	6	2	5	4.9	CC1=C2C(=CC(=C1)CC(C3=NC4=CC=CC=C4C=C3)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL1770717	calrl_human	Human	No	8.9	IC50	=	1.4	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	601	3	2	9	3.4	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)C4(CC4)C(F)(F)F)NC(=O)N5CCC6(CC5)C7=C(NC6=O)N=CC=C7
CHEMBL1770719	calrl_human	Human	No	8.9	IC50	=	1.4	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	565	4	2	7	2.0	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F)OC
CHEMBL2024596	calrl_human	Human	No	8.9	IC50	=	1.4	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	560	5	3	4	4.3	CC1=C2C(=CC(=C1)CC(C3=NC4=CC=CC=C4C=C3)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2024597	calrl_human	Human	No	8.9	IC50	=	1.4	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	561	6	2	5	4.9	CC1=C2C(=CC(=C1)CC(C3=NC4=CC=CC=C4C=C3)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL1770725	calrl_human	Human	No	8.8	IC50	=	1.5	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	567	3	3	8	1.8	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)O
CHEMBL1092208	calrl_human	Human	No	8.8	IC50	=	1.5	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serumAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serum	502	3	2	5	3.4	CCC12CC(=O)NC3=C1C(=CC=C3)N(C2)CC4=NC5=CC6=C(CC7(C6)C8=C(NC7=O)N=CC=C8)C=C5C=C4
CHEMBL2024593	calrl_human	Human	No	8.8	IC50	=	1.5	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	511	6	2	5	3.6	CC1=C2C(=CC(=C1)CC(C3=CC=CC=N3)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL1770725	calrl_human	Human	No	8.8	IC50	=	1.5	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	567	3	3	8	1.8	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)O
CHEMBL1092208	calrl_human	Human	No	8.8	IC50	=	1.5	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serumAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serum	502	3	2	5	3.4	CCC12CC(=O)NC3=C1C(=CC=C3)N(C2)CC4=NC5=CC6=C(CC7(C6)C8=C(NC7=O)N=CC=C8)C=C5C=C4
CHEMBL2024593	calrl_human	Human	No	8.8	IC50	=	1.5	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	511	6	2	5	3.6	CC1=C2C(=CC(=C1)CC(C3=CC=CC=N3)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL1770556	calrl_human	Human	No	8.8	IC50	=	1.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	549	4	2	7	1.9	C1CC1C2=NN=C3N2CC(CCC3NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6)C7=C(C(=CC=C7)F)F
CHEMBL518422	calrl_human	Human	No	8.8	IC50	=	1.6	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production	504	4	2	6	2.0	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C(C=C2)NC(=O)CN5C6=CC=CC=C6N(C5=O)C7=NC=NC=C7
CHEMBL1770556	calrl_human	Human	No	8.8	IC50	=	1.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	549	4	2	7	1.9	C1CC1C2=NN=C3N2CC(CCC3NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6)C7=C(C(=CC=C7)F)F
CHEMBL2430171	calrl_human	Human	No	8.8	IC50	=	1.6	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	590	7	3	5	2.7	CC1=C2C(=CC(=C1)CC(C3=NC=CN3CC4=CC=CC=N4)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL518422	calrl_human	Human	No	8.8	IC50	=	1.6	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production	504	4	2	6	2.0	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C(C=C2)NC(=O)CN5C6=CC=CC=C6N(C5=O)C7=NC=NC=C7
CHEMBL1770718	calrl_human	Human	No	8.8	IC50	=	1.7	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	537	4	2	7	1.4	COCC1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL1770723	calrl_human	Human	No	8.8	IC50	=	1.7	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	553	4	2	8	1.7	COCC1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL1090848	calrl_human	Human	No	8.8	IC50	=	1.7	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	468	2	2	5	0.8	CN1C(=O)NC(=O)C12CC3=C(C2)C=C4C(=C3)C=CC(=N4)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL1770718	calrl_human	Human	No	8.8	IC50	=	1.7	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	537	4	2	7	1.4	COCC1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL1770723	calrl_human	Human	No	8.8	IC50	=	1.7	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	553	4	2	8	1.7	COCC1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL2430164	calrl_human	Human	No	8.8	IC50	=	1.7	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	580	7	2	6	3.3	CCN1CCN2C(=CN=C2C(CC3=CC(=C4C(=C3)C=NN4)C)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C1
CHEMBL1090848	calrl_human	Human	No	8.8	IC50	=	1.7	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	468	2	2	5	0.8	CN1C(=O)NC(=O)C12CC3=C(C2)C=C4C(=C3)C=CC(=N4)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL2369459	calrl_human	Human	No	8.8	IC50	=	1.7	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig vas deferens membrane preparationBinding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig vas deferens membrane preparation	3789	110	55	57	-15.4	CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)C(C)O)CC(=O)O)NC(=O)C(C)N)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC2=CNC=N2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(C(C)C)C(=O)N4CCCC4C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC5=CC=CC=C5)C(=O)N)C(C)O
CHEMBL500384	calrl_human	Human	No	8.7	IC50	=	1.8	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	542	6	2	5	4.1	CC1=C2C(=CC(=C1)CC(C(=O)N3CCCCC3)OC(=O)N4CCC(CC4)C5=CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2024590	calrl_human	Human	No	8.7	IC50	=	1.8	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	606	8	2	5	4.0	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C6=NC=C(C=C6)CN7CCCCC7)C=NN2
CHEMBL500384	calrl_human	Human	No	8.8	IC50	=	1.8	Funct	Antagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity at human cloned CGRP receptor expressed in mouse E10 cells assessed as inhibition of CGRP-induced cAMP production	542	6	2	5	4.1	CC1=C2C(=CC(=C1)CC(C(=O)N3CCCCC3)OC(=O)N4CCC(CC4)C5=CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2024590	calrl_human	Human	No	8.8	IC50	=	1.8	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	606	8	2	5	4.0	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C6=NC=C(C=C6)CN7CCCCC7)C=NN2
CHEMBL1770714	calrl_human	Human	No	8.7	IC50	=	1.9	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	552	5	2	7	1.6	COCC1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL2024593	calrl_human	Human	No	8.7	IC50	=	1.9	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	511	6	2	5	3.6	CC1=C2C(=CC(=C1)CC(C3=CC=CC=N3)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2023186	calrl_human	Human	No	8.7	IC50	=	1.9	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	610	8	2	7	3.1	CC1=CC(=CC2=C(NN=C12)CN3CCOCC3)CC(C4=CC=CC=N4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O
CHEMBL1770714	calrl_human	Human	No	8.7	IC50	=	1.9	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	552	5	2	7	1.6	COCC1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL2024593	calrl_human	Human	No	8.7	IC50	=	1.9	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	511	6	2	5	3.6	CC1=C2C(=CC(=C1)CC(C3=CC=CC=N3)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2430181	calrl_human	Human	No	8.7	IC50	=	1.9	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	607	7	3	5	3.9	CC1=C2C(=CC(=C1)CC(C3=NC=CN3CC4=CC=CC=C4F)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2023186	calrl_human	Human	No	8.7	IC50	=	1.9	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	610	8	2	7	3.1	CC1=CC(=CC2=C(NN=C12)CN3CCOCC3)CC(C4=CC=CC=N4)OC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O
CHEMBL530116	calrl_human	Human	No	8.0	IC50	=	10	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	447	3	2	4	1.6	CC1=CC(=C2C(=C1)N(C(=O)N2C)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL392635	calrl_human	Human	No	8.0	IC50	=	10	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	576	5	2	7	2.3	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC3=CC=CC=N3)NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL392937	calrl_human	Human	No	8.0	IC50	=	10	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	531	5	2	7	2.2	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CCF)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL482178	calrl_human	Human	No	8.0	IC50	=	10	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production	483	4	2	6	1.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)C6=NC=NC=C6
CHEMBL2024172	calrl_human	Human	No	8.0	IC50	=	10	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	537	7	2	4	4.1	CCC1=CC(=NC=C1)C(CC2=CC(=C3C(=C2)C=NN3)C)CC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL530116	calrl_human	Human	No	8.0	IC50	=	10	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	447	3	2	4	1.6	CC1=CC(=C2C(=C1)N(C(=O)N2C)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL3114486	calrl_human	Human	No	8.0	IC50	=	10	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay	633	8	1	6	4.3	CC(C)(C)CCN1C(SC(C1=O)CC(=O)N2CCC(CC2)N3CC4=CC=CC=C4NC3=O)C5=CC=CC=C5N6CCN(CC6)C
CHEMBL392635	calrl_human	Human	No	8.0	IC50	=	10	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	576	5	2	7	2.3	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC3=CC=CC=N3)NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL392937	calrl_human	Human	No	8.0	IC50	=	10	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	531	5	2	7	2.2	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CCF)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL482178	calrl_human	Human	No	8.0	IC50	=	10	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production	483	4	2	6	1.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)C6=NC=NC=C6
CHEMBL2369452	calrl_rat	Rat	No	8.0	IC50	=	10	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type alpha receptor binding sites in rat brain membraneBinding affinity against [125I]-hCalcitonin gene-related peptide type alpha receptor binding sites in rat brain membrane	2925	96	42	41	-9.9	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC4=CNC=N4)N
CHEMBL2024172	calrl_human	Human	No	8.0	IC50	=	10	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	537	7	2	4	4.1	CCC1=CC(=NC=C1)C(CC2=CC(=C3C(=C2)C=NN3)C)CC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL213976	calrl_human	Human	No	7.0	IC50	=	100	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	543	4	2	8	2.6	C1CN(CCC1N2CC(=O)NC2=O)C(=O)NC3C(=O)N(C4=CC=CC=C4C(=N3)C5=CC=CC=C5)CC(F)(F)F
CHEMBL384799	calrl_human	Human	No	7.0	IC50	=	100	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	604	5	2	7	4.5	C1CN(CCC1N2C(=O)N=C(N2)C3=CC=CC=C3)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL2018491	calrl_human	Human	No	7.0	IC50	=	100	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	650	7	3	5	3.0	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NC(=O)NC6=CC=CC=C6Cl
CHEMBL213976	calrl_human	Human	No	7.0	IC50	=	100	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	543	4	2	8	2.6	C1CN(CCC1N2CC(=O)NC2=O)C(=O)NC3C(=O)N(C4=CC=CC=C4C(=N3)C5=CC=CC=C5)CC(F)(F)F
CHEMBL384799	calrl_human	Human	No	7.0	IC50	=	100	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	604	5	2	7	4.5	C1CN(CCC1N2C(=O)N=C(N2)C3=CC=CC=C3)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL2018491	calrl_human	Human	No	7.0	IC50	=	100	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	650	7	3	5	3.0	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NC(=O)NC6=CC=CC=C6Cl
CHEMBL198105	calrl_human	Human	No	6.0	IC50	=	1000	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	790	15	5	8	3.9	COC1=CC=CC=C1CCNC(=O)NC(CC2=CC(=C(C(=C2)Br)O)Br)C(=O)NC(CCCCN)C(=O)N3CCN(CC3)C4=CC=NC=C4
CHEMBL238275	calrl_human	Human	No	6.0	IC50	=	1000	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	465	3	4	5	1.2	C1CC(C(=O)NCC1C2=CC=C(C=C2)O)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL198105	calrl_human	Human	No	6.0	IC50	=	1000	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	790	15	5	8	3.9	COC1=CC=CC=C1CCNC(=O)NC(CC2=CC(=C(C(=C2)Br)O)Br)C(=O)NC(CCCCN)C(=O)N3CCN(CC3)C4=CC=NC=C4
CHEMBL238275	calrl_human	Human	No	6.0	IC50	=	1000	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	465	3	4	5	1.2	C1CC(C(=O)NCC1C2=CC=C(C=C2)O)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL269027	calrl_human	Human	No	5.0	IC50	=	10000	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1224	39	19	21	-6.8	CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)O)N
CHEMBL405694	calrl_human	Human	No	5.0	IC50	=	10000	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1206	35	18	20	-9.0	CC(C)C(C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCC(=O)N)C(=O)NCC(=O)NC(CC2=CC=C(C=C2)O)C(=O)O)NC(=O)C(CC(=O)N)N
CHEMBL216229	calrl_human	Human	No	5.0	IC50	=	10000	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1312	37	19	21	-8.0	CC(C)C(C(=O)NCC(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)NC(=O)C(CC(=O)N)NC(=O)C(C(C)O)NC(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC(=O)N)N
CHEMBL267137	calrl_human	Human	No	5.0	IC50	=	10000	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1493	45	20	22	-6.9	CCC(C)C(C(=O)NC(CO)C(=O)N1CCCC1C(=O)NC(CCC(=O)N)C(=O)NCC(=O)NC(CC2=CC=C(C=C2)O)C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(C(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC(=O)N)N
CHEMBL267182	calrl_human	Human	No	5.0	IC50	=	10000	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1416	43	19	22	-9.4	CCC(C)C(C(=O)NC(CO)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(C)NC(=O)C(C(C)C)NC(=O)C(CC(=O)N)N
CHEMBL409205	calrl_human	Human	No	5.0	IC50	=	10000	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1282	37	18	20	-7.4	CC(C)C(C(=O)NCC(=O)NC(CO)C(=O)NC(CCC(=O)N)C(=O)NCC(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)NC(=O)C(CC(=O)N)NC(=O)C(C(C)O)NC(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC(=O)N)N
CHEMBL438008	calrl_human	Human	No	5.0	IC50	=	10000	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1205	35	17	20	-7.6	CC(C)C(C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CC(=O)N)N
CHEMBL438224	calrl_human	Human	No	5.0	IC50	=	10000	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1492	45	19	22	-7.8	CCC(C)C(C(=O)NC(CO)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CCCN=C(N)N)NC(=O)C3CCCN3C(=O)C(C(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC(=O)N)N
CHEMBL257094	calrl_human	Human	No	6.0	IC50	=	1004	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based assay	525	6	2	7	1.4	COCCN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=C(C(=CC=C5)F)F
CHEMBL257094	calrl_human	Human	No	6.0	IC50	=	1004	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based assay	525	6	2	7	1.4	COCCN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=C(C(=CC=C5)F)F
CHEMBL198311	calrl_human	Human	No	5.0	IC50	=	10300	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	758	15	4	7	4.0	C1CN(CCN1C2=CC=NC=C2)C(=O)C(CCCCN)NC(=O)C(CC3=CC(=C(C(=C3)Br)N)Br)NC(=O)CCCC4=CC=CC=C4
CHEMBL198311	calrl_human	Human	No	5.0	IC50	=	10300	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	758	15	4	7	4.0	C1CN(CCN1C2=CC=NC=C2)C(=O)C(CCCCN)NC(=O)C(CC3=CC(=C(C(=C3)Br)N)Br)NC(=O)CCCC4=CC=CC=C4
CHEMBL403373	calrl_human	Human	No	6.0	IC50	=	1066	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	445	3	2	5	0.2	CN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=CN=CC=C5
CHEMBL403373	calrl_human	Human	No	6.0	IC50	=	1066	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	445	3	2	5	0.2	CN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=CN=CC=C5
CHEMBL215274	calrl_human	Human	No	7.0	IC50	=	107	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	621	5	2	8	4.6	C1CN(CCC1N2C=C(NC2=O)C3=CC=C(C=C3)F)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL215274	calrl_human	Human	No	7.0	IC50	=	107	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	621	5	2	8	4.6	C1CN(CCC1N2C=C(NC2=O)C3=CC=C(C=C3)F)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL268420	calrl_human	Human	No	7.0	IC50	=	107.2	Funct	Antagonist activity against human CGRP1 expressed in HEK293 cells assessed as inhibition of human alpha-CGRP-promoted cAMP productionAntagonist activity against human CGRP1 expressed in HEK293 cells assessed as inhibition of human alpha-CGRP-promoted cAMP production	1221	29	12	15	-0.2	CC(C)C(C(=O)NC1CCC2CCC(N2C1=O)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(C)C(=O)NC(CC4=CC=CC=C4)C(=O)N)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C5CCCN5C(=O)C(C(C)C)NC(=O)C(CC6=CC=CC=C6)N
CHEMBL268420	calrl_human	Human	No	7.0	IC50	=	107.2	Funct	Antagonist activity against human CGRP1 expressed in HEK293 cells assessed as inhibition of human alpha-CGRP-promoted cAMP productionAntagonist activity against human CGRP1 expressed in HEK293 cells assessed as inhibition of human alpha-CGRP-promoted cAMP production	1221	29	12	15	-0.2	CC(C)C(C(=O)NC1CCC2CCC(N2C1=O)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(C)C(=O)NC(CC4=CC=CC=C4)C(=O)N)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C5CCCN5C(=O)C(C(C)C)NC(=O)C(CC6=CC=CC=C6)N
CHEMBL258070	calrl_human	Human	No	5.0	IC50	=	10900	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based assay	444	3	2	4	1.3	CN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=CC=CC=C5
CHEMBL258070	calrl_human	Human	No	5.0	IC50	=	10900	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based assay	444	3	2	4	1.3	CN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=CC=CC=C5
CHEMBL236593	calrl_human	Human	Yes	8.0	IC50	=	11	Funct	Antagonist activity against human CGRP receptor in presence of 50% human serum by cell based cAMP accumulation assayAntagonist activity against human CGRP receptor in presence of 50% human serum by cell based cAMP accumulation assay	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL236593	calrl_human	Human	Yes	8.0	IC50	=	11	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL2018518	calrl_human	Human	No	8.0	IC50	=	11	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	626	7	2	5	3.5	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL236593	calrl_human	Human	Yes	8.0	IC50	=	11	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL236593	calrl_human	Human	Yes	8.0	IC50	=	11	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serumAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serum	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL570531	calrl_human	Human	No	8.0	IC50	=	11	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assay	566	3	2	9	3.1	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)CC(=O)NC5=C4C=CC=N5
CHEMBL571203	calrl_human	Human	No	8.0	IC50	=	11	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay	552	3	2	9	2.8	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)C5=C(NC4=O)N=CC=C5
CHEMBL236593	calrl_human	Human	Yes	8.0	IC50	=	11	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL570531	calrl_human	Human	No	8.0	IC50	=	11	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay	566	3	2	9	3.1	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)CC(=O)NC5=C4C=CC=N5
CHEMBL2018518	calrl_human	Human	No	8.0	IC50	=	11	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	626	7	2	5	3.5	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL236593	calrl_human	Human	Yes	8.0	IC50	=	11	Funct	Antagonist activity against human CGRP receptor in presence of 50% human serum by cell based cAMP accumulation assayAntagonist activity against human CGRP receptor in presence of 50% human serum by cell based cAMP accumulation assay	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL236593	calrl_human	Human	Yes	8.0	IC50	=	11	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL2018518	calrl_human	Human	No	8.0	IC50	=	11	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	626	7	2	5	3.5	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL236593	calrl_human	Human	Yes	8.0	IC50	=	11	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL236593	calrl_human	Human	Yes	8.0	IC50	=	11	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serumAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serum	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL570531	calrl_human	Human	No	8.0	IC50	=	11	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assay	566	3	2	9	3.1	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)CC(=O)NC5=C4C=CC=N5
CHEMBL571203	calrl_human	Human	No	8.0	IC50	=	11	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay	552	3	2	9	2.8	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)C5=C(NC4=O)N=CC=C5
CHEMBL236593	calrl_human	Human	Yes	8.0	IC50	=	11	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL570531	calrl_human	Human	No	8.0	IC50	=	11	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay	566	3	2	9	3.1	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)CC(=O)NC5=C4C=CC=N5
CHEMBL2369454	calrl_rat	Rat	No	8.0	IC50	=	11	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type alpha receptor binding sites in rat brain membraneBinding affinity against [125I]-hCalcitonin gene-related peptide type alpha receptor binding sites in rat brain membrane	3060	100	44	43	-9.9	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(C(C)C)N
CHEMBL2018518	calrl_human	Human	No	8.0	IC50	=	11	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	626	7	2	5	3.5	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7)C=NN2
CHEMBL2369457	calrl_human	Human	No	8.0	IC50	=	11.2	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig atrium membraneBinding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig atrium membrane	3084	100	45	44	-11.4	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC4=CNC=N4)NC(=O)C(C(C)O)NC(=O)C(C(C)C)N
CHEMBL221009	calrl_human	Human	No	7.0	IC50	=	110	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	405	3	3	4	0.7	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5NC4=O
CHEMBL376292	calrl_human	Human	No	7.0	IC50	=	110	Funct	Inhibition of CGRP-induced cAMP production in E10 cellsInhibition of CGRP-induced cAMP production in E10 cells	483	4	2	6	1.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)C6=NC=CC=N6
CHEMBL221009	calrl_human	Human	No	7.0	IC50	=	110	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	405	3	3	4	0.7	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5NC4=O
CHEMBL376292	calrl_human	Human	No	7.0	IC50	=	110	Funct	Inhibition of CGRP-induced cAMP production in E10 cellsInhibition of CGRP-induced cAMP production in E10 cells	483	4	2	6	1.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)C6=NC=CC=N6
CHEMBL570793	calrl_human	Human	No	7.0	IC50	=	112	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay	527	4	2	9	2.3	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)C4=CC=NNC4=O
CHEMBL570793	calrl_human	Human	No	7.0	IC50	=	112	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay	527	4	2	9	2.3	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)C4=CC=NNC4=O
CHEMBL386113	calrl_human	Human	No	6.0	IC50	=	1135	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	578	4	2	8	3.5	C1CN(CCC1N2C3=C(C=CC=N3)NC2=O)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL386113	calrl_human	Human	No	6.0	IC50	=	1135	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	578	4	2	8	3.5	C1CN(CCC1N2C3=C(C=CC=N3)NC2=O)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL256901	calrl_human	Human	No	6.9	IC50	=	119	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	530	4	2	8	2.5	C1CN(CCC1N2C3=C(NC2=O)N=CC=C3)C(=O)NC4=CC(=CN(C4=O)CC(F)(F)F)C5=CC(=CC=C5)F
CHEMBL256901	calrl_human	Human	No	6.9	IC50	=	119	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	530	4	2	8	2.5	C1CN(CCC1N2C3=C(NC2=O)N=CC=C3)C(=O)NC4=CC(=CN(C4=O)CC(F)(F)F)C5=CC(=CC=C5)F
CHEMBL255999	calrl_human	Human	No	5.9	IC50	=	1190	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	490	6	2	6	0.1	COCCN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=CN=CC=C5
CHEMBL255999	calrl_human	Human	No	5.9	IC50	=	1190	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	490	6	2	6	0.1	COCCN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=CN=CC=C5
CHEMBL455458	calrl_human	Human	No	7.9	IC50	=	12	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	503	3	2	5	0.3	CN1C(=O)CCCN2C3=C(C=CC=C31)N(C2=O)CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4
CHEMBL519421	calrl_human	Human	No	7.9	IC50	=	12	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	519	5	2	5	1.2	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N(C)C)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL1770560	calrl_human	Human	No	7.9	IC50	=	12	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	538	4	3	7	1.1	C1CC(C2=NC(=CN2CC1C3=C(C(=CC=C3)F)F)CO)NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL1770564	calrl_human	Human	No	7.9	IC50	=	12	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	565	6	3	7	1.8	CNCCC1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL1770563	calrl_human	Human	No	7.9	IC50	=	12	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	538	4	3	7	1.1	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)CO)NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL1770562	calrl_human	Human	No	7.9	IC50	=	12	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	522	3	2	6	2.3	CC1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL519421	calrl_human	Human	No	7.9	IC50	=	12	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production	519	5	2	5	1.2	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N(C)C)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL2022602	calrl_human	Human	No	7.9	IC50	=	12	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	508	6	2	5	4.2	CC1=C2C(=CC(=C1)CC(C3=CC=CC=N3)OC(=O)N4CCC(CC4)C5=CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2024587	calrl_human	Human	No	7.9	IC50	=	12	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	523	6	2	4	3.7	CC1=CN=C(C=C1)C(CC2=CC(=C3C(=C2)C=NN3)C)CC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL2024600	calrl_human	Human	No	7.9	IC50	=	12	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	586	6	3	4	4.7	CC1=C2C(=CC(=C1)CC(C3=CC=CC(=N3)C4=CC=CC=C4)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL455458	calrl_human	Human	No	7.9	IC50	=	12	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	503	3	2	5	0.3	CN1C(=O)CCCN2C3=C(C=CC=C31)N(C2=O)CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4
CHEMBL519421	calrl_human	Human	No	7.9	IC50	=	12	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	519	5	2	5	1.2	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N(C)C)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL1770560	calrl_human	Human	No	7.9	IC50	=	12	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	538	4	3	7	1.1	C1CC(C2=NC(=CN2CC1C3=C(C(=CC=C3)F)F)CO)NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL1770564	calrl_human	Human	No	7.9	IC50	=	12	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	565	6	3	7	1.8	CNCCC1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL1770563	calrl_human	Human	No	7.9	IC50	=	12	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	538	4	3	7	1.1	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)CO)NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL1770562	calrl_human	Human	No	7.9	IC50	=	12	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	522	3	2	6	2.3	CC1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL519421	calrl_human	Human	No	7.9	IC50	=	12	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production	519	5	2	5	1.2	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N(C)C)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL2369454	calrl_human	Human	No	7.9	IC50	=	12	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig vas deferens membrane preparation.Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig vas deferens membrane preparation.	3060	100	44	43	-9.9	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(C(C)C)N
CHEMBL2022602	calrl_human	Human	No	7.9	IC50	=	12	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	508	6	2	5	4.2	CC1=C2C(=CC(=C1)CC(C3=CC=CC=N3)OC(=O)N4CCC(CC4)C5=CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2024587	calrl_human	Human	No	7.9	IC50	=	12	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	523	6	2	4	3.7	CC1=CN=C(C=C1)C(CC2=CC(=C3C(=C2)C=NN3)C)CC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL2024600	calrl_human	Human	No	7.9	IC50	=	12	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	586	6	3	4	4.7	CC1=C2C(=CC(=C1)CC(C3=CC=CC(=N3)C4=CC=CC=C4)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL453865	calrl_human	Human	No	6.9	IC50	=	120	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	505	6	2	5	0.3	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)CCC(=O)N(C)C
CHEMBL2018497	calrl_human	Human	No	6.9	IC50	=	120	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	630	7	3	9	2.3	CC1=NC(=NC2=NNN=C12)NC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7
CHEMBL239630	calrl_human	Human	No	6.9	IC50	=	120	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	467	3	3	5	1.6	C1CC(C(=O)NCC1C2=CC=CC=C2F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL577320	calrl_human	Human	No	6.9	IC50	=	120	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assay	579	4	2	8	3.9	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)CC(NC4=O)C5=CC=CC=C5
CHEMBL2018501	calrl_human	Human	No	6.9	IC50	=	120	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	702	7	2	5	5.8	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NC6=CC=C(C7=CC=CC=C76)Br
CHEMBL221009	calrl_human	Human	No	6.9	IC50	=	120	Funct	Inhibition of CGRP-induced cAMP production in E10 cellsInhibition of CGRP-induced cAMP production in E10 cells	405	3	3	4	0.7	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5NC4=O
CHEMBL453865	calrl_human	Human	No	6.9	IC50	=	120	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	505	6	2	5	0.3	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)CCC(=O)N(C)C
CHEMBL2430175	calrl_human	Human	No	6.9	IC50	=	120	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	513	5	4	4	2.6	CC1=C2C(=CC(=C1)CC(C3=NC=C(N3)C)NC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2018497	calrl_human	Human	No	6.9	IC50	=	120	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	630	7	3	9	2.3	CC1=NC(=NC2=NNN=C12)NC(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)C(=O)N6CCC(CC6)N7CCCCC7
CHEMBL239630	calrl_human	Human	No	6.9	IC50	=	120	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	467	3	3	5	1.6	C1CC(C(=O)NCC1C2=CC=CC=C2F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL577320	calrl_human	Human	No	6.9	IC50	=	120	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assay	579	4	2	8	3.9	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)CC(NC4=O)C5=CC=CC=C5
CHEMBL2018501	calrl_human	Human	No	6.9	IC50	=	120	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	702	7	2	5	5.8	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NC6=CC=C(C7=CC=CC=C76)Br
CHEMBL221009	calrl_human	Human	No	6.9	IC50	=	120	Funct	Inhibition of CGRP-induced cAMP production in E10 cellsInhibition of CGRP-induced cAMP production in E10 cells	405	3	3	4	0.7	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5NC4=O
CHEMBL221009	calrl_human	Human	No	5.9	IC50	=	1200	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	405	3	3	4	0.7	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5NC4=O
CHEMBL470321	calrl_human	Human	No	5.9	IC50	=	1200	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	423	3	3	5	0.8	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C(C(=CC=C5)F)NC4=O
CHEMBL520905	calrl_human	Human	No	5.9	IC50	=	1200	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	423	3	3	5	0.8	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C(C=CC(=C5)F)NC4=O
CHEMBL530116	calrl_human	Human	No	5.9	IC50	=	1200	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	447	3	2	4	1.6	CC1=CC(=C2C(=C1)N(C(=O)N2C)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL1092883	calrl_human	Human	No	5.9	IC50	=	1200	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serumAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serum	483	2	1	5	1.0	CN1C(=O)CN2C3=C(C=CC=C31)N(C2=O)CC4=NC5=CC6=C(CC7(C6)C(=O)NC(=O)N7C)C=C5C=C4
CHEMBL221009	calrl_human	Human	No	5.9	IC50	=	1200	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	405	3	3	4	0.7	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5NC4=O
CHEMBL470321	calrl_human	Human	No	5.9	IC50	=	1200	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	423	3	3	5	0.8	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C(C(=CC=C5)F)NC4=O
CHEMBL520905	calrl_human	Human	No	5.9	IC50	=	1200	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	423	3	3	5	0.8	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C(C=CC(=C5)F)NC4=O
CHEMBL530116	calrl_human	Human	No	5.9	IC50	=	1200	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	447	3	2	4	1.6	CC1=CC(=C2C(=C1)N(C(=O)N2C)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL1092883	calrl_human	Human	No	5.9	IC50	=	1200	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serumAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serum	483	2	1	5	1.0	CN1C(=O)CN2C3=C(C=CC=C31)N(C2=O)CC4=NC5=CC6=C(CC7(C6)C(=O)NC(=O)N7C)C=C5C=C4
CHEMBL216710	calrl_human	Human	No	5.9	IC50	=	1200	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1167	33	15	18	-4.2	CC(C)C(C(=O)NCC(=O)NC(CO)C(=O)NC(CCC(=O)N)C(=O)NC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C(CC3=CC=CC=C3)N
CHEMBL88441	calrl_human	Human	No	4.9	IC50	=	12000	Funct	Displacement of [125I]hCGRP human Calcitonin gene-related peptide type receptor expressed in SK-N-MC neuroblastoma cell membranesDisplacement of [125I]hCGRP human Calcitonin gene-related peptide type receptor expressed in SK-N-MC neuroblastoma cell membranes	495	7	1	5	6.3	CCC1CN2CCC1CC2C(C3=CC(=NC4=C3C=C(C=C4)OC)C5=CC=C(C=C5)OC6=CC=CC=C6)O
CHEMBL577957	calrl_human	Human	No	6.9	IC50	=	122	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay	517	3	3	9	1.7	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)C(=O)NC(=O)N4
CHEMBL577957	calrl_human	Human	No	6.9	IC50	=	122	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay	517	3	3	9	1.7	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)C(=O)NC(=O)N4
CHEMBL3114460	calrl_human	Human	No	5.9	IC50	=	1220	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay	509	7	1	5	2.1	COCCN1C(SC(C1=O)CC(=O)N2CCC(CC2)N3CC4=CC=CC=C4NC3=O)C5=CC=CC=C5
CHEMBL487068	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	491	5	3	5	0.6	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL455458	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	503	3	2	5	0.3	CN1C(=O)CCCN2C3=C(C=CC=C31)N(C2=O)CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4
CHEMBL1770727	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	649	5	2	11	3.4	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)OCC(F)(F)F
CHEMBL2024172	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	537	7	2	4	4.1	CCC1=CC(=NC=C1)C(CC2=CC(=C3C(=C2)C=NN3)C)CC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL1162991	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serumAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serum	489	3	2	5	0.4	CC1=CC2=C3C(=C1)N(C(=O)CN3C(=O)N2CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4)C
CHEMBL570748	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assay	542	4	2	9	2.6	CC1=NNC(=O)C(=C1)C2CCN(CC2)C(=O)NC3CCC(CN(C3=O)CC(F)(F)F)C4=C(C(=CC=C4)F)F
CHEMBL570746	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay	568	3	2	10	3.1	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5
CHEMBL466192	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	474	3	3	5	0.2	CC1=CC2=C3C(=C1)NC(=O)CN3C(=O)N2CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4
CHEMBL487068	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	491	5	3	5	0.6	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL455458	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	503	3	2	5	0.3	CN1C(=O)CCCN2C3=C(C=CC=C31)N(C2=O)CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4
CHEMBL1770727	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	649	5	2	11	3.4	CC(C)(C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F)OCC(F)(F)F
CHEMBL2024172	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	537	7	2	4	4.1	CCC1=CC(=NC=C1)C(CC2=CC(=C3C(=C2)C=NN3)C)CC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL1162991	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serumAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serum	489	3	2	5	0.4	CC1=CC2=C3C(=C1)N(C(=O)CN3C(=O)N2CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4)C
CHEMBL570748	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assay	542	4	2	9	2.6	CC1=NNC(=O)C(=C1)C2CCN(CC2)C(=O)NC3CCC(CN(C3=O)CC(F)(F)F)C4=C(C(=CC=C4)F)F
CHEMBL570746	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay	568	3	2	10	3.1	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5
CHEMBL466192	calrl_human	Human	No	7.9	IC50	=	13	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	474	3	3	5	0.2	CC1=CC2=C3C(=C1)NC(=O)CN3C(=O)N2CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4
CHEMBL487077	calrl_human	Human	No	6.9	IC50	=	130	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	419	3	3	4	1.1	CC1=CC2=C(C=C1)NC(=O)N2CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3
CHEMBL521076	calrl_human	Human	No	6.9	IC50	=	130	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	462	5	3	5	-0.2	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)CC(=O)N
CHEMBL2018356	calrl_human	Human	No	6.9	IC50	=	130	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	627	8	3	6	2.4	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NCC6=CC7=C(C=C6)NN=C7
CHEMBL487077	calrl_human	Human	No	6.9	IC50	=	130	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	419	3	3	4	1.1	CC1=CC2=C(C=C1)NC(=O)N2CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3
CHEMBL521076	calrl_human	Human	No	6.9	IC50	=	130	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	462	5	3	5	-0.2	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)CC(=O)N
CHEMBL2018356	calrl_human	Human	No	6.9	IC50	=	130	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	627	8	3	6	2.4	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NCC6=CC7=C(C=C6)NN=C7
CHEMBL198762	calrl_human	Human	No	4.9	IC50	=	13000	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	748	17	6	6	5.1	COC1=CC=CC=C1CCNC(=O)NC(CC2=CC(=C(C(=C2)Br)O)Br)C(=O)NC(CCCCN)C(=O)NCCC3=CC=CC=C3
CHEMBL198762	calrl_human	Human	No	4.9	IC50	=	13000	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	748	17	6	6	5.1	COC1=CC=CC=C1CCNC(=O)NC(CC2=CC(=C(C(=C2)Br)O)Br)C(=O)NC(CCCCN)C(=O)NCCC3=CC=CC=C3
CHEMBL3114469	calrl_human	Human	No	5.9	IC50	=	1370	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay	556	7	1	5	3.2	C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)CC4C(=O)N(C(S4)C5=CC=CC=C5)CCC6=CC=CC=N6
CHEMBL415453	calrl_human	Human	No	5.9	IC50	=	1381	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	578	4	2	8	3.2	C1CN(CCC1N2C3=C(C=NC=C3)NC2=O)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL415453	calrl_human	Human	No	5.9	IC50	=	1381	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	578	4	2	8	3.2	C1CN(CCC1N2C3=C(C=NC=C3)NC2=O)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL3114487	calrl_human	Human	No	4.9	IC50	=	13900	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay	633	8	1	6	4.3	CC(C)(C)CCN1C(SC(C1=O)CC(=O)N2CCC(CC2)N3CC4=CC=CC=C4NC3=O)C5=CC=CC=C5N6CCN(CC6)C
CHEMBL426142	calrl_human	Human	No	5.9	IC50	=	1396	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	595	4	2	8	4.3	C1CN(CCC1N2C3=C(C=CC(=C3)F)NC2=O)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL426142	calrl_human	Human	No	5.9	IC50	=	1396	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	595	4	2	8	4.3	C1CN(CCC1N2C3=C(C=CC(=C3)F)NC2=O)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL384723	calrl_human	Human	No	5.9	IC50	=	1398	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	578	4	2	8	3.2	C1CN(CCC1N2C3=C(C=CN=C3)NC2=O)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL384723	calrl_human	Human	No	5.9	IC50	=	1398	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	578	4	2	8	3.2	C1CN(CCC1N2C3=C(C=CN=C3)NC2=O)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL215499	calrl_human	Human	No	7.9	IC50	=	14	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	603	5	2	7	4.5	C1CN(CCC1N2C=C(NC2=O)C3=CC=CC=C3)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL455674	calrl_human	Human	No	7.9	IC50	=	14	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	489	3	3	5	0.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C6C(=CC=C5)NC(=O)CCCN6C4=O
CHEMBL519421	calrl_human	Human	No	7.9	IC50	=	14	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% rhesus monkey serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% rhesus monkey serum	519	5	2	5	1.2	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N(C)C)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL2024600	calrl_human	Human	No	7.9	IC50	=	14	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	586	6	3	4	4.7	CC1=C2C(=CC(=C1)CC(C3=CC=CC(=N3)C4=CC=CC=C4)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL237661	calrl_human	Human	No	7.9	IC50	=	14	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	485	3	3	6	1.7	C1CC(C(=O)NCC1C2=C(C(=CC=C2)F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL1090848	calrl_human	Human	No	7.9	IC50	=	14	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serumAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serum	468	2	2	5	0.8	CN1C(=O)NC(=O)C12CC3=C(C2)C=C4C(=C3)C=CC(=N4)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL215499	calrl_human	Human	No	7.9	IC50	=	14	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	603	5	2	7	4.5	C1CN(CCC1N2C=C(NC2=O)C3=CC=CC=C3)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL455674	calrl_human	Human	No	7.9	IC50	=	14	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	489	3	3	5	0.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C6C(=CC=C5)NC(=O)CCCN6C4=O
CHEMBL519421	calrl_human	Human	No	7.9	IC50	=	14	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% rhesus monkey serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% rhesus monkey serum	519	5	2	5	1.2	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N(C)C)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL2024600	calrl_human	Human	No	7.9	IC50	=	14	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	586	6	3	4	4.7	CC1=C2C(=CC(=C1)CC(C3=CC=CC(=N3)C4=CC=CC=C4)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL237661	calrl_human	Human	No	7.9	IC50	=	14	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	485	3	3	6	1.7	C1CC(C(=O)NCC1C2=C(C(=CC=C2)F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL1090848	calrl_human	Human	No	7.9	IC50	=	14	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serumAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serum	468	2	2	5	0.8	CN1C(=O)NC(=O)C12CC3=C(C2)C=C4C(=C3)C=CC(=N4)CN5C6=C7C(=CC=C6)NC(=O)CN7C5=O
CHEMBL2369742	calrl_human	Human	No	7.9	IC50	=	14	Funct	In vitro ability to displace [125 I]CGRP from Calcitonin gene-related peptide type receptor at 4 degrees Celsius in rabbit porcine c+iIn vitro ability to displace [125 I]CGRP from Calcitonin gene-related peptide type receptor at 4 degrees Celsius in rabbit porcine c+i	3334	106	50	50	-15.1	CC(C)C(C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)CNC(=O)C(CO)NC(=O)C(CCCN=C(N)N)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(C(C)C)NC(=O)C(CC4=CNC=N4)NC(=O)C(C(C)C)NC(=O)C(CS)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(CC(=O)O)NC(=O)C(CS)NC(=O)C(C)N
CHEMBL2369457	calrl_human	Human	No	7.8	IC50	=	14.5	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig vas deferens membrane preparation.Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig vas deferens membrane preparation.	3084	100	45	44	-11.4	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC4=CNC=N4)NC(=O)C(C(C)O)NC(=O)C(C(C)C)N
CHEMBL487068	calrl_human	Human	No	6.9	IC50	=	140	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	491	5	3	5	0.6	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL487068	calrl_human	Human	No	6.9	IC50	=	140	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	491	5	3	5	0.6	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL2059903	calrl_human	Human	No	5.9	IC50	=	1400	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	628	6	2	7	3.4	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C(=O)NC(=N6)C7=CC=NC=C7
CHEMBL2018493	calrl_human	Human	No	5.9	IC50	=	1400	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	575	7	2	7	2.5	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NC6=NC=NC=C6
CHEMBL221160	calrl_human	Human	No	5.9	IC50	=	1400	Funct	Inhibition of CGRP-induced cAMP production in E10 cellsInhibition of CGRP-induced cAMP production in E10 cells	406	3	2	5	1.3	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5OC4=O
CHEMBL2059903	calrl_human	Human	No	5.9	IC50	=	1400	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	628	6	2	7	3.4	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C(=O)NC(=N6)C7=CC=NC=C7
CHEMBL2018493	calrl_human	Human	No	5.9	IC50	=	1400	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	575	7	2	7	2.5	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NC6=NC=NC=C6
CHEMBL221160	calrl_human	Human	No	5.9	IC50	=	1400	Funct	Inhibition of CGRP-induced cAMP production in E10 cellsInhibition of CGRP-induced cAMP production in E10 cells	406	3	2	5	1.3	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5OC4=O
CHEMBL376040	calrl_human	Human	No	4.9	IC50	=	14000	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1231	34	16	19	-4.0	CC(C)C(C(=O)NCC(=O)NC(CO)C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC(=O)N)NC(=O)C(C(C)O)NC(=O)C2CCCN2C(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CC=C(C=C4)O)N
CHEMBL270175	calrl_human	Human	No	6.9	IC50	=	142	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	460	3	3	5	0.9	CN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=CC(=CC=C5)O
CHEMBL270175	calrl_human	Human	No	6.9	IC50	=	142	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	460	3	3	5	0.9	CN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=CC(=CC=C5)O
CHEMBL402887	calrl_human	Human	No	5.9	IC50	=	1421	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based assay	502	4	3	8	0.7	C1CN(CCC1N2C3=C(NC2=O)N=CC=C3)C(=O)NC4=CC(=CN(C4=O)CC(F)(F)F)C5=CC=NN5
CHEMBL402887	calrl_human	Human	No	5.9	IC50	=	1421	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based assay	502	4	3	8	0.7	C1CN(CCC1N2C3=C(NC2=O)N=CC=C3)C(=O)NC4=CC(=CN(C4=O)CC(F)(F)F)C5=CC=NN5
CHEMBL2371143	calrl_human	Human	No	6.8	IC50	=	146	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1376	42	15	17	-1.7	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C1=CC=CC=C1)NC(=O)C(C(C)C2=CC=CC=C2)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)N
CHEMBL1770564	calrl_human	Human	No	7.8	IC50	=	15	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	565	6	3	7	1.8	CNCCC1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL236590	calrl_human	Human	No	7.8	IC50	=	15	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	529	5	3	7	1.2	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CCO)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL237849	calrl_human	Human	No	7.8	IC50	=	15	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	549	5	2	8	2.7	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL2018514	calrl_human	Human	No	7.8	IC50	=	15	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	599	6	2	6	3.3	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CC4=C(C=C3)NN=C4)CC(=O)N5CCC6(CC5)C7=CC=CC=C7NC(=O)O6
CHEMBL1770564	calrl_human	Human	No	7.8	IC50	=	15	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	565	6	3	7	1.8	CNCCC1=CN=C2N1CC(CCC2NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL236590	calrl_human	Human	No	7.8	IC50	=	15	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	529	5	3	7	1.2	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CCO)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL237849	calrl_human	Human	No	7.8	IC50	=	15	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	549	5	2	8	2.7	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL2018514	calrl_human	Human	No	7.8	IC50	=	15	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	599	6	2	6	3.3	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CC4=C(C=C3)NN=C4)CC(=O)N5CCC6(CC5)C7=CC=CC=C7NC(=O)O6
CHEMBL487076	calrl_human	Human	No	6.8	IC50	=	150	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	423	3	3	5	0.8	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C(C=C(C=C5)F)NC4=O
CHEMBL521076	calrl_human	Human	No	6.8	IC50	=	150	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	462	5	3	5	-0.2	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)CC(=O)N
CHEMBL488082	calrl_human	Human	No	6.8	IC50	=	150	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	506	6	2	6	1.5	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)OC)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL241118	calrl_human	Human	No	6.8	IC50	=	150	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	467	3	3	5	1.6	C1CC(C(=O)NCC1C2=CC=CC=C2F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL2059898	calrl_human	Human	No	6.8	IC50	=	150	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	614	5	2	5	4.8	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)CNC(=O)C7=CC=CC=C67
CHEMBL487076	calrl_human	Human	No	6.8	IC50	=	150	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	423	3	3	5	0.8	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C(C=C(C=C5)F)NC4=O
CHEMBL521076	calrl_human	Human	No	6.8	IC50	=	150	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	462	5	3	5	-0.2	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)CC(=O)N
CHEMBL488082	calrl_human	Human	No	6.8	IC50	=	150	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	506	6	2	6	1.5	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)OC)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL241118	calrl_human	Human	No	6.8	IC50	=	150	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	467	3	3	5	1.6	C1CC(C(=O)NCC1C2=CC=CC=C2F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL2059898	calrl_human	Human	No	6.8	IC50	=	150	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	614	5	2	5	4.8	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)CNC(=O)C7=CC=CC=C67
CHEMBL488065	calrl_human	Human	No	5.8	IC50	=	1500	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	435	4	3	5	0.7	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C(C=CC(=C5)OC)NC4=O
CHEMBL488065	calrl_human	Human	No	5.8	IC50	=	1500	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	435	4	3	5	0.7	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C(C=CC(=C5)OC)NC4=O
CHEMBL3114681	calrl_human	Human	No	5.8	IC50	=	1500	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay	493	5	1	4	3.1	CC(C)N1C(SC(C1=O)CC(=O)N2CCC(CC2)N3CC4=CC=CC=C4NC3=O)C5=CC=CC=C5
CHEMBL256802	calrl_human	Human	No	5.8	IC50	=	1528	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	475	4	2	5	1.3	CN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=CC=C(C=C5)OC
CHEMBL256802	calrl_human	Human	No	5.8	IC50	=	1528	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	475	4	2	5	1.3	CN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=CC=C(C=C5)OC
CHEMBL384408	calrl_human	Human	No	6.8	IC50	=	156	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	585	6	2	9	2.9	COC(=O)C1=CN(C(=O)N1)C2CCN(CC2)C(=O)NC3C(=O)N(C4=CC=CC=C4C(=N3)C5=CC=CC=C5)CC(F)(F)F
CHEMBL384408	calrl_human	Human	No	6.8	IC50	=	156	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	585	6	2	9	2.9	COC(=O)C1=CN(C(=O)N1)C2CCN(CC2)C(=O)NC3C(=O)N(C4=CC=CC=C4C(=N3)C5=CC=CC=C5)CC(F)(F)F
CHEMBL381798	calrl_human	Human	No	5.8	IC50	=	1583	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	577	4	2	7	4.2	C1CN(CCC1N2C3=CC=CC=C3NC2=O)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL381798	calrl_human	Human	No	5.8	IC50	=	1583	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	577	4	2	7	4.2	C1CN(CCC1N2C3=CC=CC=C3NC2=O)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL406459	calrl_human	Human	Yes	6.8	IC50	=	159	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1170	31	13	16	-0.4	CC(C)C(C(=O)NCC(=O)NC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C3CCCN3C(=O)C(C(C)C)NC(=O)C(CC4=CC=CC=C4)N
CHEMBL438120	calrl_human	Human	No	7.8	IC50	=	16	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	556	6	2	7	1.9	CN(C)CCN1CC(CCC(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=C(C(=CC=C5)F)F
CHEMBL438120	calrl_human	Human	No	7.8	IC50	=	16	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	556	6	2	7	1.9	CN(C)CCN1CC(CCC(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=C(C(=CC=C5)F)F
CHEMBL2369464	calrl_human	Human	No	7.8	IC50	=	16	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig vas deferens membrane preparation.Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig vas deferens membrane preparation.	2788	92	40	39	-9.5	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)N
CHEMBL480999	calrl_human	Human	No	6.8	IC50	=	160	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	475	3	2	5	1.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5C6(C4=O)CCOCC6
CHEMBL3114475	calrl_human	Human	No	6.8	IC50	=	160	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay	620	8	1	6	4.1	CC(C)(C)CCN1C(SC(C1=O)CC(=O)N2CCC(CC2)N3CC4=CC=CC=C4NC3=O)C5=CC=CC=C5N6CCOCC6
CHEMBL480999	calrl_human	Human	No	6.8	IC50	=	160	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	475	3	2	5	1.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5C6(C4=O)CCOCC6
CHEMBL257094	calrl_human	Human	No	6.8	IC50	=	164	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	525	6	2	7	1.4	COCCN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=C(C(=CC=C5)F)F
CHEMBL257094	calrl_human	Human	No	6.8	IC50	=	164	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	525	6	2	7	1.4	COCCN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=C(C(=CC=C5)F)F
CHEMBL2369464	calrl_rat	Rat	No	7.8	IC50	=	17.9	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type alpha receptor binding sites in rat brain membraneBinding affinity against [125I]-hCalcitonin gene-related peptide type alpha receptor binding sites in rat brain membrane	2788	92	40	39	-9.5	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)N
CHEMBL270796	calrl_human	Human	No	6.8	IC50	=	170	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	505	6	3	6	0.8	COCCN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=CC=C(C=C5)O
CHEMBL220101	calrl_human	Human	No	6.8	IC50	=	170	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	476	4	2	5	0.9	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)C6CCOC6
CHEMBL2059895	calrl_human	Human	No	6.8	IC50	=	170	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	600	5	2	5	4.4	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C7=CC=CC=C7NC6=O
CHEMBL2018499	calrl_human	Human	No	6.8	IC50	=	170	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	613	7	3	6	3.5	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NC6=CC7=C(C=C6)NN=C7
CHEMBL3114473	calrl_human	Human	No	6.8	IC50	=	170	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay	571	7	1	6	4.6	CC(C)(C)CCN1C(SC(C1=O)CC(=O)N2CCC(CC2)N3CC4=CC=CC=C4NC3=O)C5=C(C=CC=C5F)F
CHEMBL270796	calrl_human	Human	No	6.8	IC50	=	170	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	505	6	3	6	0.8	COCCN1C=C(C=C(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=CC=C(C=C5)O
CHEMBL220101	calrl_human	Human	No	6.8	IC50	=	170	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	476	4	2	5	0.9	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)C6CCOC6
CHEMBL411804	calrl_human	Human	No	6.8	IC50	=	170	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1184	31	13	16	-0.2	CC(C)C(C(=O)NCC(=O)NC(C)(C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C3CCCN3C(=O)C(C(C)C)NC(=O)C(CC4=CC=CC=C4)N
CHEMBL2059895	calrl_human	Human	No	6.8	IC50	=	170	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	600	5	2	5	4.4	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C7=CC=CC=C7NC6=O
CHEMBL2018499	calrl_human	Human	No	6.8	IC50	=	170	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	613	7	3	6	3.5	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NC6=CC7=C(C=C6)NN=C7
CHEMBL198232	calrl_human	Human	No	4.8	IC50	=	17000	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	717	17	5	5	5.6	C1=CC=C(C=C1)CCCC(=O)NC(CC2=CC(=C(C(=C2)Br)O)Br)C(=O)NC(CCCCN)C(=O)NCCC3=CC=CC=C3
CHEMBL196582	calrl_human	Human	No	4.8	IC50	=	17000	Funct	Antagonist activity against human CGRP receptorAntagonist activity against human CGRP receptor	717	17	5	5	5.6	C1=CC=C(C=C1)CCCC(=O)NC(CC2=CC(=C(C(=C2)Br)O)Br)C(=O)NC(CCCCN)C(=O)NCCC3=CC=CC=C3
CHEMBL198232	calrl_human	Human	No	4.8	IC50	=	17000	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	717	17	5	5	5.6	C1=CC=C(C=C1)CCCC(=O)NC(CC2=CC(=C(C(=C2)Br)O)Br)C(=O)NC(CCCCN)C(=O)NCCC3=CC=CC=C3
CHEMBL196582	calrl_human	Human	No	4.8	IC50	=	17000	Funct	Antagonist activity against human CGRP receptorAntagonist activity against human CGRP receptor	717	17	5	5	5.6	C1=CC=C(C=C1)CCCC(=O)NC(CC2=CC(=C(C(=C2)Br)O)Br)C(=O)NC(CCCCN)C(=O)NCCC3=CC=CC=C3
CHEMBL313797	calrl_human	Human	No	4.8	IC50	=	17000	Funct	Displacement of [125I]hCGRP human Calcitonin gene-related peptide type receptor expressed in SK-N-MC neuroblastoma cell membranesDisplacement of [125I]hCGRP human Calcitonin gene-related peptide type receptor expressed in SK-N-MC neuroblastoma cell membranes	455	5	1	5	5.5	CCC1CN2CCC1CC2C(C3=CC(=NC4=C3C=C(C=C4)OC)C5=CC(=C(C=C5)F)Cl)O
CHEMBL2024587	calrl_human	Human	No	7.8	IC50	=	18	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	523	6	2	4	3.7	CC1=CN=C(C=C1)C(CC2=CC(=C3C(=C2)C=NN3)C)CC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL257252	calrl_human	Human	No	7.8	IC50	=	18	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	548	4	2	9	2.6	C1CN(CCC1N2C3=C(NC2=O)N=CC=C3)C(=O)NC4=CC(=CN(C4=O)CC(F)(F)F)C5=C(C(=CC=C5)F)F
CHEMBL2024587	calrl_human	Human	No	7.8	IC50	=	18	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	523	6	2	4	3.7	CC1=CN=C(C=C1)C(CC2=CC(=C3C(=C2)C=NN3)C)CC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL257252	calrl_human	Human	No	7.8	IC50	=	18	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	548	4	2	9	2.6	C1CN(CCC1N2C3=C(NC2=O)N=CC=C3)C(=O)NC4=CC(=CN(C4=O)CC(F)(F)F)C5=C(C(=CC=C5)F)F
CHEMBL2018498	calrl_human	Human	No	6.8	IC50	=	180	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	612	7	3	5	4.0	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NC6=CC7=C(C=C6)NC=C7
CHEMBL374666	calrl_human	Human	No	6.8	IC50	=	180	Funct	Inhibition of CGRP-induced cAMP production in E10 cellsInhibition of CGRP-induced cAMP production in E10 cells	517	4	2	6	2.7	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)C6=CC(=CC(=C6)F)F
CHEMBL3114470	calrl_human	Human	No	6.8	IC50	=	180	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay	553	7	1	5	4.5	CC(C)(C)CCN1C(SC(C1=O)CC(=O)N2CCC(CC2)N3CC4=CC=CC=C4NC3=O)C5=CC=CC=C5F
CHEMBL2018498	calrl_human	Human	No	6.8	IC50	=	180	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	612	7	3	5	4.0	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NC6=CC7=C(C=C6)NC=C7
CHEMBL374666	calrl_human	Human	No	6.8	IC50	=	180	Funct	Inhibition of CGRP-induced cAMP production in E10 cellsInhibition of CGRP-induced cAMP production in E10 cells	517	4	2	6	2.7	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)C6=CC(=CC(=C6)F)F
CHEMBL240686	calrl_human	Human	No	5.8	IC50	=	1800	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	455	3	3	5	1.2	C1CC(C(=O)NCC1C2=CSC=C2)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL240686	calrl_human	Human	No	5.8	IC50	=	1800	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	455	3	3	5	1.2	C1CC(C(=O)NCC1C2=CSC=C2)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL267406	calrl_human	Human	No	4.8	IC50	=	18000	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	987	29	15	17	-5.3	CC(C)C(C(=O)NCC(=O)NC(CO)C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC(=O)N)NC(=O)C(C(C)O)NC(=O)C(CC2=CC=C(C=C2)O)N
CHEMBL215424	calrl_human	Human	No	5.7	IC50	=	1837	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	592	4	2	8	3.1	C1CN(CCC1N2CC3=C(C=CC=N3)NC2=O)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL215424	calrl_human	Human	No	5.7	IC50	=	1837	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	592	4	2	8	3.1	C1CN(CCC1N2CC3=C(C=CC=N3)NC2=O)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL1794015	calrl_human	Human	No	6.7	IC50	=	185	Funct	In vitro ability to displace [125 I]CGRP from Calcitonin gene-related peptide type receptor at 4 degrees Centigrade in rabbit lungIn vitro ability to displace [125 I]CGRP from Calcitonin gene-related peptide type receptor at 4 degrees Centigrade in rabbit lung	3189	105	47	51	-17.4	CC(C)CC(C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)COCCOCCNC(=O)C(C(C)C)NC(=O)C(CS)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(CC(=O)O)NC(=O)C(CS)NC(=O)C(C)N
CHEMBL428247	calrl_human	Human	No	6.7	IC50	=	186	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	530	4	2	8	2.5	C1CN(CCC1N2C3=C(NC2=O)N=CC=C3)C(=O)NC4=CC(=CN(C4=O)CC(F)(F)F)C5=CC=CC=C5F
CHEMBL428247	calrl_human	Human	No	6.7	IC50	=	186	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	530	4	2	8	2.5	C1CN(CCC1N2C3=C(NC2=O)N=CC=C3)C(=O)NC4=CC(=CN(C4=O)CC(F)(F)F)C5=CC=CC=C5F
CHEMBL1770558	calrl_human	Human	No	7.7	IC50	=	19	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	508	3	2	6	1.9	C1CC(C2=NC=CN2CC1C3=C(C(=CC=C3)F)F)NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL2018512	calrl_human	Human	No	7.7	IC50	=	19	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	530	5	2	5	3.1	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC4(CC3)C5=CC=CC=C5NC(=O)O4)C(=O)N6CCCCC6)C=NN2
CHEMBL1770558	calrl_human	Human	No	7.7	IC50	=	19	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	508	3	2	6	1.9	C1CC(C2=NC=CN2CC1C3=C(C(=CC=C3)F)F)NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL3114488	calrl_human	Human	No	7.7	IC50	=	19	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay	647	8	1	6	4.8	CC(C)(C)CCN1C(SC(C1=O)CC(=O)N2CCC(CC2)N3CCC4=CC=CC=C4NC3=O)C5=CC=CC=C5N6CCN(CC6)C
CHEMBL2018512	calrl_human	Human	No	7.7	IC50	=	19	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	530	5	2	5	3.1	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC4(CC3)C5=CC=CC=C5NC(=O)O4)C(=O)N6CCCCC6)C=NN2
CHEMBL3114472	calrl_human	Human	No	6.7	IC50	=	190	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay	571	7	1	6	4.6	CC(C)(C)CCN1C(SC(C1=O)CC(=O)N2CCC(CC2)N3CC4=CC=CC=C4NC3=O)C5=C(C=C(C=C5)F)F
CHEMBL3350392	calrl_human	Human	No	4.7	IC50	=	19000	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1183	33	16	19	-4.6	CC(C)C(C(=O)NCC(=O)NC(CO)C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC(=O)N)NC(=O)C(C(C)O)NC(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C(CC3=CC=C(C=C3)O)N
CHEMBL214800	calrl_human	Human	No	6.7	IC50	=	193	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	633	6	2	8	4.4	COC1=CC=C(C=C1)C2=CN(C(=O)N2)C3CCN(CC3)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL214800	calrl_human	Human	No	6.7	IC50	=	193	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	633	6	2	8	4.4	COC1=CC=C(C=C1)C2=CN(C(=O)N2)C3CCN(CC3)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL236593	calrl_human	Human	Yes	8.7	IC50	=	2	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL1770720	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	591	3	2	10	3.4	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC5(CC4)C6=C(NC(=O)O5)N=CC=C6
CHEMBL2018511	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	557	6	2	4	3.4	CC1CCN(CC1)C(=O)C(CC2=CC(=C3C(=C2)C=NN3)C)CC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL237662	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	543	6	2	7	1.7	COCCN1CC(CCC(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=C(C(=CC=C5)F)F
CHEMBL237663	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	539	5	2	6	2.6	C1CC1CN2CC(CCC(C2=O)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL392635	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	576	5	2	7	2.3	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC3=CC=CC=N3)NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL415263	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	559	6	2	7	2.5	CSCCN1CC(CCC(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=C(C(=CC=C5)F)F
CHEMBL392636	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	591	6	2	8	1.3	CS(=O)(=O)CCN1CC(CCC(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=C(C(=CC=C5)F)F
CHEMBL562069	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serumAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serum	463	3	3	4	1.8	C1C2=CN(C3=C2C(=CC=C3)NC1=O)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
CHEMBL236593	calrl_human	Human	Yes	8.7	IC50	=	2	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assay	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL2024596	calrl_human	Human	No	8.7	IC50	=	2	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	560	5	3	4	4.3	CC1=C2C(=CC(=C1)CC(C3=NC4=CC=CC=C4C=C3)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2024602	calrl_human	Human	No	8.7	IC50	=	2	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	541	7	3	6	2.7	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CO)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL236593	calrl_human	Human	Yes	8.7	IC50	=	2	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL1770720	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	591	3	2	10	3.4	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC5(CC4)C6=C(NC(=O)O5)N=CC=C6
CHEMBL3114494	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay	679	9	1	7	5.2	CCN1CCN(CC1)C2=C(C=CC=C2F)C3N(C(=O)C(S3)CC(=O)N4CCC(CC4)N5CCC6=CC=CC=C6NC5=O)CCC(C)(C)C
CHEMBL2018511	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	557	6	2	4	3.4	CC1CCN(CC1)C(=O)C(CC2=CC(=C3C(=C2)C=NN3)C)CC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL237662	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	543	6	2	7	1.7	COCCN1CC(CCC(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=C(C(=CC=C5)F)F
CHEMBL237663	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	539	5	2	6	2.6	C1CC1CN2CC(CCC(C2=O)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL392635	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	576	5	2	7	2.3	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC3=CC=CC=N3)NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL415263	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	559	6	2	7	2.5	CSCCN1CC(CCC(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=C(C(=CC=C5)F)F
CHEMBL392636	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	591	6	2	8	1.3	CS(=O)(=O)CCN1CC(CCC(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=C(C(=CC=C5)F)F
CHEMBL562069	calrl_human	Human	No	8.7	IC50	=	2	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serumAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serum	463	3	3	4	1.8	C1C2=CN(C3=C2C(=CC=C3)NC1=O)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
CHEMBL236593	calrl_human	Human	Yes	8.7	IC50	=	2	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assay	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL2369459	calrl_human	Human	No	8.7	IC50	=	2	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig atrium membraneBinding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig atrium membrane	3789	110	55	57	-15.4	CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)C(C)O)CC(=O)O)NC(=O)C(C)N)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC2=CNC=N2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(C(C)C)C(=O)N4CCCC4C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC5=CC=CC=C5)C(=O)N)C(C)O
CHEMBL2024596	calrl_human	Human	No	8.7	IC50	=	2	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	560	5	3	4	4.3	CC1=C2C(=CC(=C1)CC(C3=NC4=CC=CC=C4C=C3)NC(=O)N5CCC(CC5)N6CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2024602	calrl_human	Human	No	8.7	IC50	=	2	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	541	7	3	6	2.7	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CO)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL3037882	calrl_human	Human	No	8.7	IC50	=	2	Funct	In vitro ability to displace [125 I]CGRP from Calcitonin gene-related peptide type receptor at 4 degrees Celsius in rabbit lung; value ranges from (2-5)In vitro ability to displace [125 I]CGRP from Calcitonin gene-related peptide type receptor at 4 degrees Celsius in rabbit lung; value ranges from (2-5)	3793	122	58	59	-20.9	CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC4=CNC=N4)NC(=O)C(C(C)O)NC(=O)C(C(C)C)NC(=O)C(CS)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(CC(=O)O)NC(=O)C(CS)NC(=O)C(C)N
CHEMBL3037882	calrl_human	Human	No	8.7	IC50	=	2	Funct	In vitro ability to displace [125 I]CGRP from Calcitonin gene-related peptide type receptor at 4 degrees Celsius in rabbit porcine c+iIn vitro ability to displace [125 I]CGRP from Calcitonin gene-related peptide type receptor at 4 degrees Celsius in rabbit porcine c+i	3793	122	58	59	-20.9	CC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC4=CNC=N4)NC(=O)C(C(C)O)NC(=O)C(C(C)C)NC(=O)C(CS)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(CC(=O)O)NC(=O)C(CS)NC(=O)C(C)N
CHEMBL2024602	calrl_human	Human	No	8.7	IC50	=	2.1	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	541	7	3	6	2.7	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CO)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL2024602	calrl_human	Human	No	8.7	IC50	=	2.1	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	541	7	3	6	2.7	CC1=C2C(=CC(=C1)CC(C3=NC=CC(=C3)CO)OC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O)C=NN2
CHEMBL236593	calrl_human	Human	Yes	8.7	IC50	=	2.2	Funct	Antagonist activity against human CGRP receptor by cell based cAMP accumulation assayAntagonist activity against human CGRP receptor by cell based cAMP accumulation assay	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL236593	calrl_human	Human	Yes	8.7	IC50	=	2.2	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL1092838	calrl_human	Human	No	8.7	IC50	=	2.2	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	468	2	2	5	2.2	CC12CC(=O)NC3=C1C(=CC=C3)N(C2)CC4=NC5=CC6=C(CC7(C6)C(=O)NC(=O)N7C)C=C5C=C4
CHEMBL236593	calrl_human	Human	Yes	8.7	IC50	=	2.2	Funct	Antagonist activity against human CGRP receptor by cell based cAMP accumulation assayAntagonist activity against human CGRP receptor by cell based cAMP accumulation assay	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL236593	calrl_human	Human	Yes	8.7	IC50	=	2.2	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL1092838	calrl_human	Human	No	8.7	IC50	=	2.2	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	468	2	2	5	2.2	CC12CC(=O)NC3=C1C(=CC=C3)N(C2)CC4=NC5=CC6=C(CC7(C6)C(=O)NC(=O)N7C)C=C5C=C4
CHEMBL1770721	calrl_human	Human	No	8.6	IC50	=	2.3	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	576	3	2	10	2.6	C1CC(C2=NN=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC5(CC4)C6=C(NC5=O)N=CC=C6
CHEMBL1770721	calrl_human	Human	No	8.6	IC50	=	2.3	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	576	3	2	10	2.6	C1CC(C2=NN=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC5(CC4)C6=C(NC5=O)N=CC=C6
CHEMBL525571	calrl_human	Human	No	8.6	IC50	=	2.3	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig atrium membraneBinding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig atrium membrane	3126	104	47	44	-9.3	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC4=CN=CN4)NC(=O)C(C(C)O)NC(=O)C(C(C)C)N
CHEMBL2369463	calrl_human	Human	No	8.6	IC50	=	2.3	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig atrium membraneBinding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig atrium membrane	3027	99	44	43	-10.8	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC4=CNC=N4)NC(=O)C(C(C)O)N
CHEMBL453643	calrl_human	Human	No	8.6	IC50	=	2.4	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	460	3	3	5	-0.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C6C(=CC=C5)NC(=O)CN6C4=O
CHEMBL1770556	calrl_human	Human	No	8.6	IC50	=	2.4	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	549	4	2	7	1.9	C1CC1C2=NN=C3N2CC(CCC3NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6)C7=C(C(=CC=C7)F)F
CHEMBL564088	calrl_human	Human	Yes	8.6	IC50	=	2.4	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay	466	3	3	5	1.6	C1C2CN(C3=CC=CC(=C23)NC1=O)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
CHEMBL236593	calrl_human	Human	Yes	8.6	IC50	=	2.4	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL453643	calrl_human	Human	No	8.6	IC50	=	2.4	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	460	3	3	5	-0.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C6C(=CC=C5)NC(=O)CN6C4=O
CHEMBL466192	calrl_human	Human	No	8.6	IC50	=	2.4	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production	474	3	3	5	0.2	CC1=CC2=C3C(=C1)NC(=O)CN3C(=O)N2CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4
CHEMBL453643	calrl_human	Human	No	8.6	IC50	=	2.4	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	460	3	3	5	-0.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C6C(=CC=C5)NC(=O)CN6C4=O
CHEMBL1770556	calrl_human	Human	No	8.6	IC50	=	2.4	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	549	4	2	7	1.9	C1CC1C2=NN=C3N2CC(CCC3NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6)C7=C(C(=CC=C7)F)F
CHEMBL236593	calrl_human	Human	Yes	8.6	IC50	=	2.4	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay	567	4	2	9	3.0	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL453643	calrl_human	Human	No	8.6	IC50	=	2.4	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production	460	3	3	5	-0.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C6C(=CC=C5)NC(=O)CN6C4=O
CHEMBL2369459	calrl_rat	Rat	No	8.6	IC50	=	2.4	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type alpha receptor binding sites in rat brain membraneBinding affinity against [125I]-hCalcitonin gene-related peptide type alpha receptor binding sites in rat brain membrane	3789	110	55	57	-15.4	CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)C(C)O)CC(=O)O)NC(=O)C(C)N)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CC2=CNC=N2)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(C(C)C)C(=O)N4CCCC4C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC5=CC=CC=C5)C(=O)N)C(C)O
CHEMBL1092882	calrl_human	Human	No	8.6	IC50	=	2.5	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serumAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serum	489	2	2	5	1.7	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C5C(=C2)C=CC(=N5)CN6C7=C8C(=CC=C7)NC(=O)CN8C6=O
CHEMBL464078	calrl_human	Human	No	8.6	IC50	=	2.5	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production	526	4	2	5	3.0	C1CSCCC1N2C3=CC=CC=C3N(C2=O)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
CHEMBL1092882	calrl_human	Human	No	8.6	IC50	=	2.5	Funct	Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serumAntagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in the presence of 50% human serum	489	2	2	5	1.7	C1C2=C(CC13C4=C(NC3=O)N=CC=C4)C=C5C(=C2)C=CC(=N5)CN6C7=C8C(=CC=C7)NC(=O)CN8C6=O
CHEMBL464078	calrl_human	Human	No	8.6	IC50	=	2.5	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production	526	4	2	5	3.0	C1CSCCC1N2C3=CC=CC=C3N(C2=O)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
CHEMBL1770566	calrl_human	Human	No	8.6	IC50	=	2.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	584	4	2	6	3.6	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)C4=CC=CC=C4)NC(=O)N5CCC(CC5)N6C7=C(NC6=O)N=CC=C7
CHEMBL1770557	calrl_human	Human	No	8.6	IC50	=	2.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	590	4	2	9	3.3	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL1770566	calrl_human	Human	No	8.6	IC50	=	2.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay	584	4	2	6	3.6	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)C4=CC=CC=C4)NC(=O)N5CCC(CC5)N6C7=C(NC6=O)N=CC=C7
CHEMBL1770557	calrl_human	Human	No	8.6	IC50	=	2.6	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	590	4	2	9	3.3	C1CC(C2=NC=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
CHEMBL382469	calrl_human	Human	No	8.6	IC50	=	2.7	Funct	Affinity against calcitonin gene related peptide receptor (1 uM) in marmoset tissue homogenates using [125I]CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against calcitonin gene related peptide receptor (1 uM) in marmoset tissue homogenates using [125I]CGRP as radioligand after 180 minutes of incubation at pH 7.40	856	12	5	8	3.2	C1CN(CCC1N2C3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL1770721	calrl_human	Human	No	8.6	IC50	=	2.7	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	576	3	2	10	2.6	C1CC(C2=NN=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC5(CC4)C6=C(NC5=O)N=CC=C6
CHEMBL570746	calrl_human	Human	No	8.6	IC50	=	2.7	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assay	568	3	2	10	3.1	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5
CHEMBL3288290	calrl_human	Human	No	8.6	IC50	=	2.7	Funct	Displacement of [125I]-hCGRP from CGRP receptor in human SK-N-MC cell membranes after 2 hrs by scintillation counting analysisDisplacement of [125I]-hCGRP from CGRP receptor in human SK-N-MC cell membranes after 2 hrs by scintillation counting analysis	766	12	4	9	3.1	C1CN(CCC1N2C(=O)C3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC5=CC=CC=C5S4)C(=O)NC(CCCCN)C(=O)N6CCN(CC6)C7=CC=NC=C7
CHEMBL2018511	calrl_human	Human	No	8.6	IC50	=	2.7	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	557	6	2	4	3.4	CC1CCN(CC1)C(=O)C(CC2=CC(=C3C(=C2)C=NN3)C)CC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL382469	calrl_human	Human	No	8.6	IC50	=	2.7	Funct	Affinity against calcitonin gene related peptide receptor (1 uM) in marmoset tissue homogenates using [125I]CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against calcitonin gene related peptide receptor (1 uM) in marmoset tissue homogenates using [125I]CGRP as radioligand after 180 minutes of incubation at pH 7.40	856	12	5	8	3.2	C1CN(CCC1N2C3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
CHEMBL1770721	calrl_human	Human	No	8.6	IC50	=	2.7	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	576	3	2	10	2.6	C1CC(C2=NN=C(N2CC1C3=C(C(=CC=C3)F)F)CC(F)(F)F)NC(=O)N4CCC5(CC4)C6=C(NC5=O)N=CC=C6
CHEMBL570746	calrl_human	Human	No	8.6	IC50	=	2.7	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assay	568	3	2	10	3.1	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5
CHEMBL3288290	calrl_human	Human	No	8.6	IC50	=	2.7	Funct	Displacement of [125I]-hCGRP from CGRP receptor in human SK-N-MC cell membranes after 2 hrs by scintillation counting analysisDisplacement of [125I]-hCGRP from CGRP receptor in human SK-N-MC cell membranes after 2 hrs by scintillation counting analysis	766	12	4	9	3.1	C1CN(CCC1N2C(=O)C3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC5=CC=CC=C5S4)C(=O)NC(CCCCN)C(=O)N6CCN(CC6)C7=CC=NC=C7
CHEMBL2018511	calrl_human	Human	No	8.6	IC50	=	2.7	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	557	6	2	4	3.4	CC1CCN(CC1)C(=O)C(CC2=CC(=C3C(=C2)C=NN3)C)CC(=O)N4CCC(CC4)N5CC6=CC=CC=C6NC5=O
CHEMBL1770726	calrl_human	Human	No	8.5	IC50	=	2.9	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	595	5	2	8	2.7	CCOC(C)(C)C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL1770726	calrl_human	Human	No	8.5	IC50	=	2.9	Funct	Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serumAntagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum	595	5	2	8	2.7	CCOC(C)(C)C1=CN=C2N1CC(CCC2NC(=O)N3CCC4(CC3)C5=C(NC(=O)O4)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL2430163	calrl_human	Human	No	8.5	IC50	=	2.9	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	552	6	3	6	2.5	CC1=C2C(=CC(=C1)CC(C3=NC=C4N3CCNC4)OC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O)C=NN2
CHEMBL2024171	calrl_human	Human	No	7.7	IC50	=	20	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	527	6	2	5	3.4	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=C(C(=CC=C5)F)NC4=O)C6=CC=CC=N6)C=NN2
CHEMBL2059905	calrl_human	Human	No	7.7	IC50	=	20	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	616	5	2	6	4.7	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C7=CC=CC=C7NC(=O)O6
CHEMBL2059900	calrl_human	Human	No	7.7	IC50	=	20	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	627	6	2	6	4.5	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C(=O)NC(=N6)C7=CC=CC=C7
CHEMBL2024171	calrl_human	Human	No	7.7	IC50	=	20	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	527	6	2	5	3.4	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)N4CC5=C(C(=CC=C5)F)NC4=O)C6=CC=CC=N6)C=NN2
CHEMBL2059905	calrl_human	Human	No	7.7	IC50	=	20	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	616	5	2	6	4.7	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C7=CC=CC=C7NC(=O)O6
CHEMBL2059900	calrl_human	Human	No	7.7	IC50	=	20	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	627	6	2	6	4.5	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C(=O)NC(=N6)C7=CC=CC=C7
CHEMBL2369464	calrl_human	Human	No	7.7	IC50	=	20.2	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig atrium membraneBinding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig atrium membrane	2788	92	40	39	-9.5	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)N
CHEMBL198925	calrl_human	Human	No	6.7	IC50	=	200	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	790	15	5	8	3.9	COC1=CC=CC(=C1)CCNC(=O)NC(CC2=CC(=C(C(=C2)Br)O)Br)C(=O)NC(CCCCN)C(=O)N3CCN(CC3)C4=CC=NC=C4
CHEMBL198925	calrl_human	Human	No	6.7	IC50	=	200	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	790	15	5	8	3.9	COC1=CC=CC(=C1)CCNC(=O)NC(CC2=CC(=C(C(=C2)Br)O)Br)C(=O)NC(CCCCN)C(=O)N3CCN(CC3)C4=CC=NC=C4
CHEMBL429765	calrl_human	Human	No	6.7	IC50	=	200	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1023	27	12	15	-1.8	CC(C)C(C(=O)N1CCCC1C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(C)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)O)N
CHEMBL471530	calrl_human	Human	No	5.7	IC50	=	2000	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	440	3	3	4	1.3	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C(C(=CC=C5)Cl)NC4=O
CHEMBL471530	calrl_human	Human	No	5.7	IC50	=	2000	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	440	3	3	4	1.3	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C(C(=CC=C5)Cl)NC4=O
CHEMBL268539	calrl_human	Human	No	6.7	IC50	=	205	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	1212	32	13	16	2.1	CC(C)C(C(=O)NCC(=O)NC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C3CCCN3C(=O)C(C(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)C
CHEMBL255966	calrl_human	Human	No	6.7	IC50	=	209	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	512	4	2	7	2.4	C1CN(CCC1N2C3=C(NC2=O)N=CC=C3)C(=O)NC4=CC(=CN(C4=O)CC(F)(F)F)C5=CC=CC=C5
CHEMBL255966	calrl_human	Human	No	6.7	IC50	=	209	Funct	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayAntagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	512	4	2	7	2.4	C1CN(CCC1N2C3=C(NC2=O)N=CC=C3)C(=O)NC4=CC(=CN(C4=O)CC(F)(F)F)C5=CC=CC=C5
CHEMBL455674	calrl_human	Human	No	7.7	IC50	=	21	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	489	3	3	5	0.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C6C(=CC=C5)NC(=O)CCCN6C4=O
CHEMBL237663	calrl_human	Human	No	7.7	IC50	=	21	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	539	5	2	6	2.6	C1CC1CN2CC(CCC(C2=O)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL570748	calrl_human	Human	No	7.7	IC50	=	21	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay	542	4	2	9	2.6	CC1=NNC(=O)C(=C1)C2CCN(CC2)C(=O)NC3CCC(CN(C3=O)CC(F)(F)F)C4=C(C(=CC=C4)F)F
CHEMBL455674	calrl_human	Human	No	7.7	IC50	=	21	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	489	3	3	5	0.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=C6C(=CC=C5)NC(=O)CCCN6C4=O
CHEMBL237663	calrl_human	Human	No	7.7	IC50	=	21	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	539	5	2	6	2.6	C1CC1CN2CC(CCC(C2=O)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5)C6=C(C(=CC=C6)F)F
CHEMBL570748	calrl_human	Human	No	7.7	IC50	=	21	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay	542	4	2	9	2.6	CC1=NNC(=O)C(=C1)C2CCN(CC2)C(=O)NC3CCC(CN(C3=O)CC(F)(F)F)C4=C(C(=CC=C4)F)F
CHEMBL2369465	calrl_human	Human	No	7.7	IC50	=	21.9	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig vas deferens membrane preparation.Binding affinity against [125I]-hCalcitonin gene-related peptide type receptor binding sites in guinea pig vas deferens membrane preparation.	3041	98	43	43	-8.9	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CC4=CNC=N4)NC(=O)C(C(C)O)NC(=O)C(C(C)C)N
CHEMBL2059904	calrl_human	Human	No	6.7	IC50	=	210	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	628	6	2	7	3.4	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C(=O)NC(=N6)C7=CN=CC=C7
CHEMBL3114471	calrl_human	Human	No	6.7	IC50	=	210	Funct	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assayAntagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay	571	7	1	6	4.6	CC(C)(C)CCN1C(SC(C1=O)CC(=O)N2CCC(CC2)N3CC4=CC=CC=C4NC3=O)C5=C(C(=CC=C5)F)F
CHEMBL2059904	calrl_human	Human	No	6.7	IC50	=	210	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	628	6	2	7	3.4	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)C(=O)NC(=N6)C7=CN=CC=C7
CHEMBL237664	calrl_human	Human	No	7.7	IC50	=	22	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	499	3	2	6	1.9	CN1CC(CCC(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=C(C(=CC=C5)F)F
CHEMBL237661	calrl_human	Human	No	7.7	IC50	=	22	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	485	3	3	6	1.7	C1CC(C(=O)NCC1C2=C(C(=CC=C2)F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL237664	calrl_human	Human	No	7.7	IC50	=	22	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	499	3	2	6	1.9	CN1CC(CCC(C1=O)NC(=O)N2CCC(CC2)N3C4=C(NC3=O)N=CC=C4)C5=C(C(=CC=C5)F)F
CHEMBL237661	calrl_human	Human	No	7.7	IC50	=	22	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	485	3	3	6	1.7	C1CC(C(=O)NCC1C2=C(C(=CC=C2)F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL2369457	calrl_rat	Rat	No	7.7	IC50	=	22	Funct	Binding affinity against [125I]-hCalcitonin gene-related peptide type alpha receptor binding sites in rat brain membraneBinding affinity against [125I]-hCalcitonin gene-related peptide type alpha receptor binding sites in rat brain membrane	3084	100	45	44	-11.4	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC4=CNC=N4)NC(=O)C(C(C)O)NC(=O)C(C(C)C)N
CHEMBL405544	calrl_human	Human	No	6.7	IC50	=	220	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	655	5	2	9	3.5	CS(=O)(=O)C1=CC2=C(C=C1)N(C(=O)N2)C3CCN(CC3)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL453644	calrl_human	Human	No	6.7	IC50	=	220	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	474	3	2	5	0.1	CN1C(=O)CN2C3=C(C=CC=C31)N(C2=O)CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4
CHEMBL391660	calrl_human	Human	No	6.7	IC50	=	220	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	467	3	3	5	1.6	C1CC(C(=O)NCC1C2=CC(=CC=C2)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL1162991	calrl_human	Human	No	6.7	IC50	=	220	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	489	3	2	5	0.4	CC1=CC2=C3C(=C1)N(C(=O)CN3C(=O)N2CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4)C
CHEMBL520778	calrl_human	Human	No	6.7	IC50	=	220	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	506	4	2	5	2.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)C6CCSCC6
CHEMBL2018502	calrl_human	Human	No	6.7	IC50	=	220	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	623	7	2	5	5.1	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NC6=CC=CC7=CC=CC=C76
CHEMBL405544	calrl_human	Human	No	6.7	IC50	=	220	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	655	5	2	9	3.5	CS(=O)(=O)C1=CC2=C(C=C1)N(C(=O)N2)C3CCN(CC3)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL453644	calrl_human	Human	No	6.7	IC50	=	220	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	474	3	2	5	0.1	CN1C(=O)CN2C3=C(C=CC=C31)N(C2=O)CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4
CHEMBL391660	calrl_human	Human	No	6.7	IC50	=	220	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP productionAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production	467	3	3	5	1.6	C1CC(C(=O)NCC1C2=CC(=CC=C2)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL1162991	calrl_human	Human	No	6.7	IC50	=	220	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	489	3	2	5	0.4	CC1=CC2=C3C(=C1)N(C(=O)CN3C(=O)N2CC(=O)NC4=CC5=C(CC6(C5)C(=O)NC(=O)N6C)C=C4)C
CHEMBL520778	calrl_human	Human	No	6.7	IC50	=	220	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	506	4	2	5	2.1	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)C6CCSCC6
CHEMBL20034	calrl_human	Human	No	6.7	IC50	=	220	Funct	CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.CGRP1 receptor affinity on human neuroblastoma cells SK-N-MC, which selectively express the human CGRP1 receptor.	924	25	12	14	-2.1	CC(C)C(C(=O)NCC(=O)NC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C)C(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C3CCCN3
CHEMBL2018502	calrl_human	Human	No	6.7	IC50	=	220	Funct	Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation countingDisplacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting	623	7	2	5	5.1	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NC6=CC=CC7=CC=CC=C76
CHEMBL427743	calrl_human	Human	No	6.7	IC50	=	224	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	592	4	2	8	3.1	C1CN(CCC1N2CC3=C(C=NC=C3)NC2=O)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL427743	calrl_human	Human	No	6.7	IC50	=	224	Funct	Activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP productionActivity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production	592	4	2	8	3.1	C1CN(CCC1N2CC3=C(C=NC=C3)NC2=O)C(=O)NC4C(=O)N(C5=CC=CC=C5C(=N4)C6=CC=CC=C6)CC(F)(F)F
CHEMBL194631	calrl_human	Human	No	6.7	IC50	=	226	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	831	13	4	9	3.7	COC1=CC=CC=C1N2CCN(CC2)C(=O)NC(CC3=CC(=C(C(=C3)Br)O)Br)C(=O)NC(CCCCN)C(=O)N4CCN(CC4)C5=CC=NC=C5
CHEMBL194631	calrl_human	Human	No	6.7	IC50	=	226	Funct	Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40Affinity against human calcitonin gene related peptide receptor (1 uM) expressed in SK-N-MC cells using [125I]-CGRP as radioligand after 180 minutes of incubation at pH 7.40	831	13	4	9	3.7	COC1=CC=CC=C1N2CCN(CC2)C(=O)NC(CC3=CC(=C(C(=C3)Br)O)Br)C(=O)NC(CCCCN)C(=O)N4CCN(CC4)C5=CC=NC=C5
CHEMBL471358	calrl_human	Human	No	7.6	IC50	=	23	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	433	3	3	4	1.4	CC1=CC(=C2C(=C1)N(C(=O)N2)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL519421	calrl_human	Human	No	7.6	IC50	=	23	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	519	5	2	5	1.2	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N(C)C)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL236590	calrl_human	Human	No	7.6	IC50	=	23	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	529	5	3	7	1.2	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CCO)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL549503	calrl_human	Human	Yes	7.6	IC50	=	23	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serumAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serum	480	3	3	5	2.0	C1CC(=O)NC2=C3C1CN(C3=CC=C2)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
CHEMBL577110	calrl_human	Human	No	7.6	IC50	=	23	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assay	578	4	2	9	3.6	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)C(=O)NC(=N4)C5=CC=CC=C5
CHEMBL519421	calrl_human	Human	No	7.6	IC50	=	23	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	519	5	2	5	1.2	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N(C)C)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL2059896	calrl_human	Human	No	7.6	IC50	=	23	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	614	5	2	5	4.7	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)CC(=O)NC7=CC=CC=C67
CHEMBL471358	calrl_human	Human	No	7.6	IC50	=	23	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP productionAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production	433	3	3	4	1.4	CC1=CC(=C2C(=C1)N(C(=O)N2)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL519421	calrl_human	Human	No	7.6	IC50	=	23	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	519	5	2	5	1.2	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N(C)C)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL236590	calrl_human	Human	No	7.6	IC50	=	23	Funct	Antagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serumAntagonist activity at human CL receptor expressed in E10 cells assessed as CGRP-stimulated cAMP production in presence of 50% human serum	529	5	3	7	1.2	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CCO)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
CHEMBL549503	calrl_human	Human	Yes	7.6	IC50	=	23	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serumAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serum	480	3	3	5	2.0	C1CC(=O)NC2=C3C1CN(C3=CC=C2)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
CHEMBL577110	calrl_human	Human	No	7.6	IC50	=	23	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assayAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins by scintillation proximity assay	578	4	2	9	3.6	C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC4(CC3)C(=O)NC(=N4)C5=CC=CC=C5
CHEMBL519421	calrl_human	Human	No	7.6	IC50	=	23	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	519	5	2	5	1.2	CC1=CC(=C2C(=C1)N(C(=O)N2CC(=O)N(C)C)CC(=O)NC3=CC4=C(CC5(C4)C(=O)NC(=O)N5C)C=C3)C
CHEMBL2059896	calrl_human	Human	No	7.6	IC50	=	23	Funct	Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cellsDisplacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells	614	5	2	5	4.7	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC3=CSC4=CC=CC=C43)NC(=O)N5CCC6(CC5)CC(=O)NC7=CC=CC=C67
CHEMBL2018499	calrl_human	Human	No	6.6	IC50	=	230	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	613	7	3	6	3.5	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NC6=CC7=C(C=C6)NN=C7
CHEMBL2018499	calrl_human	Human	No	6.6	IC50	=	230	Funct	Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP productionAntagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production	613	7	3	6	3.5	C1CCN(CC1)C2CCN(CC2)C(=O)C(CC(=O)N3CCC(CC3)N4CC5=CC=CC=C5NC4=O)NC6=CC7=C(C=C6)NN=C7
CHEMBL455670	calrl_human	Human	No	7.6	IC50	=	24	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	519	7	2	5	0.7	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)CCCC(=O)N(C)C
CHEMBL564088	calrl_human	Human	Yes	7.6	IC50	=	24	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serumAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serum	466	3	3	5	1.6	C1C2CN(C3=CC=CC(=C23)NC1=O)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
CHEMBL464078	calrl_human	Human	No	7.6	IC50	=	24	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	526	4	2	5	3.0	C1CSCCC1N2C3=CC=CC=C3N(C2=O)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
CHEMBL2024591	calrl_human	Human	No	7.6	IC50	=	24	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	506	6	2	4	4.0	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)C4=CC5=CC=CC=C5NC4=O)C6=CC=CC=N6)C=NN2
CHEMBL375533	calrl_human	Human	No	7.6	IC50	=	24	Funct	Inhibition of CGRP-induced cAMP production in E10 cellsInhibition of CGRP-induced cAMP production in E10 cells	489	4	2	6	1.8	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)C6=NC=CS6
CHEMBL455670	calrl_human	Human	No	7.6	IC50	=	24	Funct	Antagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonist activity against human cloned CGRP receptor expressed in HEK93 cells assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	519	7	2	5	0.7	CN1C(=O)NC(=O)C12CC3=C(C2)C=C(C=C3)NC(=O)CN4C5=CC=CC=C5N(C4=O)CCCC(=O)N(C)C
CHEMBL564088	calrl_human	Human	Yes	7.6	IC50	=	24	Funct	Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serumAntagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 30 mins by scintillation proximity assay in presence of 50% human serum	466	3	3	5	1.6	C1C2CN(C3=CC=CC(=C23)NC1=O)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
CHEMBL464078	calrl_human	Human	No	7.6	IC50	=	24	Funct	Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serumAntagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in presence of 50% human serum	526	4	2	5	3.0	C1CSCCC1N2C3=CC=CC=C3N(C2=O)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
CHEMBL2024591	calrl_human	Human	No	7.6	IC50	=	24	Funct	Displacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation countingDisplacement of [I125]CGRP from CGRP receptor in human SK-N-MC cell membrane after 2 hrs by gamma or scintillation counting	506	6	2	4	4.0	CC1=C2C(=CC(=C1)CC(CC(=O)N3CCC(CC3)C4=CC5=CC=CC=C5NC4=O)C6=CC=CC=N6)C=NN2
CHEMBL375533	calrl_human	Human	No	7.6	IC50	=	24	Funct

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Ligand source activities (1 row/activity)