DP2 receptor (pd2r2_mouse)
FAMILY
Class A (Rhodopsin) Lipid receptors Prostanoid receptors DP2 receptor
GENE
Ptgdr2 (Crth2, Gpr44)
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
Prostaglandin D2 receptor 2, Chemoattractant receptor-homologous molecule expressed on Th2 cells, G-protein coupled receptor 44, CD294
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
N
|
V
|
T
|
L
|
K
|
P
|
L
|
C
|
10 |
P
|
L
|
L
|
E
|
E
|
M
|
V
|
Q
|
L
|
P
|
20 |
N
|
H
|
S
|
N
|
S
|
S
|
L
|
R
|
Y
|
I
|
30 |
TM1 | |||||||||
D
|
H
|
V
|
S
|
V
|
L
|
L
|
H
|
G
|
L
|
40 |
A
|
S
|
L
|
L
|
G
|
L
|
V
|
E
|
N
|
G
|
50 |
L
|
I
|
L
|
F
|
V
|
V
|
G
|
C
|
R
|
M
|
60 |
ICL1 | TM2 | ||||||||
R
|
Q
|
T
|
V
|
V
|
T
|
T
|
W
|
V
|
L
|
70 |
H
|
L
|
A
|
L
|
S
|
D
|
L
|
L
|
A
|
A
|
80 |
A
|
S
|
L
|
P
|
F
|
F
|
T
|
Y
|
F
|
L
|
90 |
ECL1 | |||||||||
A
|
V
|
G
|
H
|
S
|
W
|
E
|
L
|
G
|
T
|
100 |
TM3 | |||||||||
T
|
F
|
C
|
K
|
L
|
H
|
S
|
S
|
V
|
F
|
110 |
F
|
L
|
N
|
M
|
F
|
A
|
S
|
G
|
F
|
L
|
120 |
L
|
S
|
A
|
I
|
S
|
L
|
D
|
R
|
C
|
L
|
130 |
ICL2 | |||||||||
Q
|
V
|
V
|
R
|
P
|
V
|
W
|
A
|
Q
|
N
|
140 |
TM4 | |||||||||
H
|
R
|
T
|
V
|
A
|
V
|
A
|
H
|
R
|
V
|
150 |
C
|
L
|
M
|
L
|
W
|
A
|
L
|
A
|
V
|
L
|
160 |
N
|
T
|
I
|
P
|
Y
|
F
|
V
|
F
|
R
|
D
|
170 |
ECL2 | |||||||||
T
|
I
|
P
|
R
|
L
|
D
|
G
|
R
|
I
|
M
|
180 |
C
|
Y
|
Y
|
N
|
L
|
L
|
L
|
W
|
N
|
P
|
190 |
TM5 | |||||||||
G
|
P
|
D
|
R
|
D
|
T
|
T
|
C
|
D
|
Y
|
200 |
R
|
Q
|
K
|
A
|
L
|
A
|
V
|
S
|
K
|
F
|
210 |
L
|
L
|
A
|
F
|
M
|
V
|
P
|
L
|
A
|
I
|
220 |
I
|
A
|
S
|
S
|
H
|
V
|
A
|
V
|
S
|
L
|
230 |
ICL3 | |||||||||
R
|
L
|
H
|
H
|
R
|
G
|
R
|
Q
|
R
|
T
|
240 |
TM6 | |||||||||
G
|
R
|
F
|
V
|
R
|
L
|
V
|
A
|
A
|
I
|
250 |
V
|
V
|
A
|
F
|
V
|
L
|
C
|
W
|
G
|
P
|
260 |
Y
|
H
|
I
|
F
|
S
|
L
|
L
|
E
|
A
|
R
|
270 |
ECL3 | TM7 | ||||||||
A
|
H
|
S
|
V
|
T
|
T
|
L
|
R
|
Q
|
L
|
280 |
A
|
S
|
R
|
G
|
L
|
P
|
F
|
V
|
T
|
S
|
290 |
L
|
A
|
F
|
F
|
N
|
S
|
V
|
V
|
N
|
P
|
300 |
H8 | |||||||||
L
|
L
|
Y
|
V
|
F
|
T
|
C
|
P
|
D
|
M
|
310 |
L
|
Y
|
K
|
L
|
R
|
R
|
S
|
L
|
R
|
A
|
320 |
C-term | |||||||||
V
|
L
|
E
|
S
|
V
|
L
|
V
|
E
|
D
|
S
|
330 |
D
|
Q
|
S
|
G
|
G
|
L
|
R
|
N
|
R
|
R
|
340 |
R
|
R
|
A
|
S
|
S
|
T
|
A
|
T
|
P
|
A
|
350 |
S
|
T
|
L
|
L
|
L
|
A
|
D
|
R
|
I
|
P
|
360 |
Q
|
L
|
R
|
P
|
T
|
R
|
L
|
I
|
G
|
W
|
370 |
M
|
R
|
R
|
G
|
S
|
A
|
E
|
V
|
P
|
Q
|
380 |
R
|
V
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PGJ2, PGD3, PGF2α, PGD2, PGE2
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available