Gz - 5-HT1A receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 88.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM5 R 225 5x68 G.H5 D 342 G.H5.13
Polar TM5 R 225 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 225 5x68 G.H5 D 342 G.H5.13
Aromatic ICL3 F 321 - G.H4 Y 303 G.H4.10
Hydrophobic ICL3 F 321 - G.H4 Y 303 G.H4.10
Van-der-waals ICL3 F 321 - G.H4 Y 303 G.H4.10
Hydrophobic TM3 I 138 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 138 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM3 R 134 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM4 T 149 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 149 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 145 34x54 G.S3 L 195 G.S3.01
Hydrophobic TM3 I 138 3x54 G.H5 I 352 G.H5.23
Hydrophobic TM5 A 222 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM5 R 225 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 R 225 5x68 G.H5 I 345 G.H5.16
Polar TM6 T 346 6x36 G.H5 G 353 G.H5.24
Hydrophobic TM6 T 346 6x36 G.H5 G 353 G.H5.24
Van-der-waals TM6 T 346 6x36 G.H5 G 353 G.H5.24
Ionic TM6 K 324 6x14 G.H4 D 310 G.H4.17
Polar TM6 K 324 6x14 G.H4 D 310 G.H4.17
Hydrophobic TM6 K 324 6x14 G.H4 D 310 G.H4.17
Van-der-waals TM6 K 324 6x14 G.H4 D 310 G.H4.17
Hydrophobic ICL2 P 141 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM6 M 335 6x25 G.h4s6 K 315 G.h4s6.08
Polar TM3 A 137 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 137 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 137 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 I 138 3x54 G.H5 N 348 G.H5.19
Van-der-waals TM3 I 138 3x54 G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 141 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 141 34x50 G.H5 I 345 G.H5.16
Hydrophobic ICL2 V 145 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 I 142 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM5 I 218 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 I 218 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 346 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM4 P 150 4x39 G.HN Q 28 G.HN.52
Hydrophobic ICL2 I 142 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 I 142 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM2 A 71 2x39 G.H5 Y 351 G.H5.22
Van-der-waals TM2 A 71 2x39 G.H5 Y 351 G.H5.22
Polar TM6 N 328 6x18 G.H4 D 310 G.H4.17
Polar TM6 N 325 6x15 G.H4 R 306 G.H4.13
Hydrophobic TM6 N 325 6x15 G.H4 R 306 G.H4.13
Van-der-waals TM6 N 325 6x15 G.H4 R 306 G.H4.13
Hydrophobic ICL2 V 145 34x54 G.S1 I 34 G.S1.02
Hydrophobic ICL2 V 145 34x54 G.H5 I 344 G.H5.15
Hydrophobic ICL2 P 141 34x50 G.H5 T 341 G.H5.12
Polar TM6 K 342 6x32 G.H5 C 355 G.H5.26
Hydrophobic TM6 K 342 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 K 342 6x32 G.H5 C 355 G.H5.26
Polar TM2 N 69 2x37 G.H5 Y 351 G.H5.22
Van-der-waals TM2 N 69 2x37 G.H5 Y 351 G.H5.22
Polar ICL1 Q 68 12x51 G.hns1 R 31 G.hns1.02
Van-der-waals ICL1 Q 68 12x51 G.hns1 R 31 G.hns1.02
Polar ICL2 N 146 34x55 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 N 146 34x55 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 N 146 34x55 G.s2s3 E 194 G.s2s3.02
Hydrophobic TM5 T 229 5x72 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 T 229 5x72 G.h4s6 E 319 G.h4s6.12
Polar TM6 T 343 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 343 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 343 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL3 P 318 - G.hgh4 G 293 G.hgh4.07
Hydrophobic TM6 L 347 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM6 M 335 6x25 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 M 335 6x25 G.h4s6 E 316 G.h4s6.09
Hydrophobic ICL2 Y 144 34x53 G.H5 N 348 G.H5.19
Hydrophobic TM6 K 342 6x32 G.H5 G 353 G.H5.24
Polar ICL3 F 321 - G.H4 R 306 G.H4.13
Hydrophobic ICL3 F 321 - G.H4 R 306 G.H4.13
Van-der-waals ICL3 F 321 - G.H4 R 306 G.H4.13
Polar TM6 R 339 6x29 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 R 339 6x29 G.h4s6 E 316 G.h4s6.09
Hydrophobic TM6 K 342 6x32 G.H5 L 354 G.H5.25
Polar TM2 N 72 2x40 G.H5 Y 351 G.H5.22
Hydrophobic TM2 N 72 2x40 G.H5 Y 351 G.H5.22
Van-der-waals TM2 N 72 2x40 G.H5 Y 351 G.H5.22
Ionic TM6 K 332 6x22 G.h4s6 E 319 G.h4s6.12
Polar ICL2 N 146 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 146 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 146 34x55 G.hns1 R 32 G.hns1.03