Gi2 - 5-HT1B receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 88.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 R 238 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 R 238 5x68 G.H5 I 345 G.H5.16
Polar ICL3 R 246 - G.H4 Q 305 G.H4.12
Hydrophobic ICL3 R 246 - G.H4 Q 305 G.H4.12
Van-der-waals ICL3 R 246 - G.H4 Q 305 G.H4.12
Hydrophobic TM6 T 315 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM5 I 231 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 I 231 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM4 T 162 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 162 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 R 308 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 R 308 6x29 G.H5 F 355 G.H5.26
Hydrophobic TM3 I 151 3x54 G.H5 L 354 G.H5.25
Polar TM3 A 150 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 150 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 150 3x53 G.H5 N 348 G.H5.19
Polar TM5 Q 242 5x72 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 Q 242 5x72 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 Q 242 5x72 G.h4s6 E 319 G.h4s6.12
Polar TM6 R 308 6x29 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 R 308 6x29 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 L 316 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 316 6x37 G.H5 L 354 G.H5.25
Polar ICL3 R 246 - G.H4 S 302 G.H4.08
Hydrophobic ICL2 V 155 34x51 G.H5 F 337 G.H5.08
Hydrophobic ICL2 V 155 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 V 155 34x51 G.H5 T 341 G.H5.12
Ionic TM5 R 238 5x68 G.H5 D 342 G.H5.13
Polar TM5 R 238 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 238 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM6 K 311 6x32 G.H5 G 353 G.H5.24
Hydrophobic ICL3 R 246 - G.S6 F 324 G.S6.05
Van-der-waals ICL3 R 246 - G.S6 F 324 G.S6.05
Polar TM6 T 315 6x36 G.H5 G 353 G.H5.24
Hydrophobic TM6 T 315 6x36 G.H5 G 353 G.H5.24
Van-der-waals TM6 T 315 6x36 G.H5 G 353 G.H5.24
Polar ICL2 A 159 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 159 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 Q 242 5x72 G.H5 F 355 G.H5.26
Hydrophobic TM6 A 312 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 312 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 L 304 6x25 G.h4s6 D 316 G.h4s6.09
Polar TM6 K 311 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 311 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 311 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM7 S 372 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM5 I 239 5x69 G.H5 F 355 G.H5.26
Polar TM3 R 147 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 147 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 147 3x50 G.H5 C 352 G.H5.23
Ionic ICL3 K 249 - G.H4 E 309 G.H4.16
Polar ICL3 K 249 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 K 249 - G.H4 E 309 G.H4.16
Hydrophobic TM5 R 238 5x68 G.H5 L 349 G.H5.20
Hydrophobic TM3 I 151 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 151 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL2 V 155 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 V 155 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM3 I 151 3x54 G.H5 C 352 G.H5.23
Hydrophobic TM5 A 235 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 A 235 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 A 154 34x50 G.H5 I 344 G.H5.15
Hydrophobic ICL2 A 154 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 A 154 34x50 G.H5 I 345 G.H5.16