Gs - 5-HT1F receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 211 5x68 G.H5 L 394 G.H5.26
Aromatic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 A 208 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM4 P 137 4x39 G.HN Q 35 G.HN.52
Ionic TM5 R 215 5x72 G.H5 D 381 G.H5.13
Polar TM5 L 211 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 211 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 L 211 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM3 I 125 3x54 G.H5 H 387 G.H5.19
Polar ICL2 R 133 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 R 133 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 V 129 34x51 G.H5 F 376 G.H5.08
Polar TM5 R 215 5x72 G.h4s6 Y 358 G.h4s6.20
Aromatic TM5 R 215 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 R 215 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 R 215 5x72 G.h4s6 Y 358 G.h4s6.20
Polar TM6 R 287 6x29 G.h4s6 Y 358 G.h4s6.20
Ionic ICL3 K 222 - G.H4 D 343 G.H4.13
Polar ICL3 K 222 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 K 222 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 K 222 - G.H4 D 343 G.H4.13
Van-der-waals TM6 R 287 6x29 G.h4s6 G 355 G.h4s6.11
Polar ICL2 V 129 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 V 129 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 V 129 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 A 132 34x54 G.S1 H 41 G.S1.02
Polar ICL2 R 135 34x57 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 135 34x57 G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 124 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 211 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 211 5x68 G.H5 L 388 G.H5.20
Polar TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 125 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 211 5x68 G.H5 Q 384 G.H5.16
Polar ICL1 H 55 12x51 G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 H 55 12x51 G.hns1 R 38 G.hns1.02
Hydrophobic TM6 T 294 6x36 G.H5 L 393 G.H5.25
Polar TM5 Y 212 5x69 G.H5 L 393 G.H5.25
Van-der-waals TM5 Y 212 5x69 G.H5 L 393 G.H5.25
Polar TM6 K 290 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 290 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 290 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 A 128 34x50 G.H5 I 383 G.H5.15
Polar TM5 Y 212 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 Y 212 5x69 G.H5 L 394 G.H5.26
Van-der-waals TM5 Y 212 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 204 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 204 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 125 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 125 3x54 G.H5 Y 391 G.H5.23
Polar ICL3 A 221 - G.hgh4 E 322 G.hgh4.12
Hydrophobic TM5 L 211 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 L 211 5x68 G.H5 D 381 G.H5.13
Hydrophobic ICL3 A 221 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 A 221 - G.hgh4 P 321 G.hgh4.11
Hydrophobic ICL2 R 133 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM4 T 136 4x38 G.HN Q 35 G.HN.52
Hydrophobic ICL3 E 224 - G.hgh4 E 322 G.hgh4.12
Van-der-waals ICL3 E 224 - G.hgh4 E 322 G.hgh4.12
Hydrophobic TM6 L 295 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 295 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 125 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 125 3x54 G.H5 L 388 G.H5.20
Polar TM3 T 126 3x55 G.H5 Q 384 G.H5.16
Polar TM5 R 215 5x72 G.S6 Y 360 G.S6.02
Van-der-waals TM5 R 215 5x72 G.S6 Y 360 G.S6.02
Polar TM6 T 294 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 294 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 294 6x36 G.H5 E 392 G.H5.24
Polar ICL2 R 135 34x57 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 135 34x57 G.H5 H 387 G.H5.19
Ionic TM6 K 290 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 290 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 290 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 290 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM3 A 124 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM7 F 350 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL2 V 129 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 129 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM2 H 56 2x37 G.hns1 R 38 G.hns1.02
Van-der-waals TM2 H 56 2x37 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 A 128 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 A 128 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 K 222 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 K 222 - G.H4 L 346 G.H4.16
Hydrophobic TM6 A 291 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 291 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 V 129 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL2 E 130 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM5 R 215 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 R 215 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL3 A 221 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 A 221 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 V 129 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 V 129 34x51 G.S3 V 217 G.S3.01
Polar ICL1 H 55 12x51 G.HN K 34 G.HN.51