G12 - 5-HT2A receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 181 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL3 T 311 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 R 185 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 185 34x55 G.hns1 R 55 G.hns1.02
Polar C-term L 408 - G.H3 K 284 G.H3.16
Van-der-waals C-term L 408 - G.H3 K 284 G.H3.16
Hydrophobic TM6 A 321 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 321 6x33 G.H5 L 375 G.H5.20
Hydrophobic ICL2 H 182 34x52 G.S3 I 221 G.S3.01
Van-der-waals ICL2 H 182 34x52 G.S3 I 221 G.S3.01
Polar C-term I 409 - G.H3 K 284 G.H3.16
Hydrophobic C-term I 409 - G.H3 K 284 G.H3.16
Van-der-waals C-term I 409 - G.H3 K 284 G.H3.16
Polar TM3 A 176 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 176 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 176 3x53 G.H5 N 374 G.H5.19
Polar TM2 N 107 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 N 107 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM3 I 177 3x54 G.H5 L 371 G.H5.16
Polar H8 N 384 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 384 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 384 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM6 A 321 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 321 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM5 L 261 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM3 I 177 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 177 3x54 G.H5 I 378 G.H5.23
Polar TM6 N 317 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM6 N 317 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 N 317 6x29 G.H5 Q 372 G.H5.17
Polar ICL2 P 180 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 180 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 180 34x50 G.H5 N 374 G.H5.19
Polar TM6 E 318 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM7 Y 380 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 380 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM4 S 188 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 I 181 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 I 181 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 P 180 34x50 G.H5 L 371 G.H5.16
Ionic TM5 E 264 5x68 G.H5 K 367 G.H5.12
Polar TM5 E 264 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM5 E 264 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 E 264 5x68 G.H5 K 367 G.H5.12
Hydrophobic ICL3 Y 306 - G.H5 E 357 G.H5.02
Van-der-waals ICL3 Y 306 - G.H5 E 357 G.H5.02
Hydrophobic TM6 L 325 6x37 G.H5 I 378 G.H5.23
Hydrophobic ICL2 I 181 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL3 Y 306 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 Y 306 - G.H5 F 361 G.H5.06
Polar H8 N 384 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 384 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 384 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 R 185 34x55 G.S1 V 58 G.S1.02
Polar C-term N 412 - G.H3 K 284 G.H3.16
Hydrophobic C-term N 412 - G.H3 K 284 G.H3.16
Van-der-waals C-term N 412 - G.H3 K 284 G.H3.16
Polar TM6 S 314 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 S 314 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 S 314 6x26 G.H5 Q 372 G.H5.17
Polar ICL3 G 308 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 G 308 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 G 308 - G.S6 H 348 G.S6.03
Polar ICL3 Y 306 - G.S6 H 349 G.S6.04
Aromatic ICL3 Y 306 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 Y 306 - G.S6 H 349 G.S6.04
Van-der-waals ICL3 Y 306 - G.S6 H 349 G.S6.04
Ionic ICL3 R 310 - G.H5 D 368 G.H5.13
Polar ICL3 R 310 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 R 310 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 R 310 - G.H5 D 368 G.H5.13
Hydrophobic C-term T 413 - G.H3 K 284 G.H3.16
Van-der-waals H8 K 385 8x48 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 R 185 34x55 G.H5 I 370 G.H5.15
Polar ICL3 Y 306 - G.s6h5 D 355 G.s6h5.05
Hydrophobic ICL2 P 180 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 180 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM3 A 176 3x53 G.H5 I 378 G.H5.23
Polar ICL2 N 187 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 N 187 34x57 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 N 187 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 I 181 34x51 G.H5 I 370 G.H5.15
Polar ICL2 R 185 34x55 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 185 34x55 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 185 34x55 G.h2s4 T 246 G.h2s4.05
Hydrophobic TM7 F 383 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 383 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL2 I 181 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM6 K 320 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 320 6x32 G.H5 M 379 G.H5.24
Van-der-waals ICL3 Y 306 - G.S6 H 348 G.S6.03
Hydrophobic TM6 N 317 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 N 317 6x29 G.H5 M 379 G.H5.24
Polar ICL2 R 185 34x55 G.S1 L 57 G.S1.01
Hydrophobic ICL2 R 185 34x55 G.S1 L 57 G.S1.01
Van-der-waals ICL2 R 185 34x55 G.S1 L 57 G.S1.01
Polar TM6 K 320 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 320 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 320 6x32 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 F 186 34x56 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 F 186 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 S 184 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 S 184 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM3 I 177 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 V 324 6x36 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 180 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 180 34x50 G.H5 K 367 G.H5.12
Polar ICL2 R 185 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 185 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 185 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 E 264 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 E 264 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM6 E 318 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 E 318 6x30 G.H5 L 375 G.H5.20
Hydrophobic ICL2 I 181 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM2 L 113 2x43 G.H5 L 380 G.H5.25
Polar ICL2 H 182 34x52 G.s2s3 K 219 G.s2s3.01
Polar TM3 R 173 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 173 3x50 G.H5 I 378 G.H5.23