G13 -
5-HT2B receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | T | 463 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | T | 463 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | T | 463 | - | H.HA | D | 101 | H.HA.24 |
Polar | ICL2 | Q | 165 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 165 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 165 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM1 | S | 80 | 1x58 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM1 | S | 80 | 1x58 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM3 | I | 157 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Polar | C-term | T | 463 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | C-term | T | 463 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | T | 463 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | TM6 | A | 322 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | A | 322 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL2 | N | 167 | 34x57 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | N | 167 | 34x57 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | C-term | L | 461 | - | H.HA | L | 106 | H.HA.29 |
Hydrophobic | TM6 | E | 319 | 6x30 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM6 | R | 321 | 6x32 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM6 | R | 321 | 6x32 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM1 | L | 81 | 1x59 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM1 | L | 81 | 1x59 | G.HN | M | 1 | G.HN.01 |
Polar | ICL2 | P | 160 | 34x50 | G.H5 | N | 370 | G.H5.19 |
Polar | ICL3 | G | 309 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | ICL3 | G | 309 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ICL3 | G | 309 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | TM7 | F | 383 | 7x56 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM7 | F | 383 | 7x56 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | I | 459 | - | H.hahb | H | 107 | H.hahb.01 |
Van-der-waals | C-term | I | 459 | - | H.hahb | H | 107 | H.hahb.01 |
Hydrophobic | C-term | L | 461 | - | H.HA | E | 104 | H.HA.27 |
Van-der-waals | C-term | L | 461 | - | H.HA | E | 104 | H.HA.27 |
Polar | H8 | N | 384 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | N | 384 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | N | 384 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | I | 157 | 3x54 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | I | 157 | 3x54 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL3 | W | 261 | - | G.S6 | F | 346 | G.S6.05 |
Van-der-waals | ICL3 | W | 261 | - | G.S6 | F | 346 | G.S6.05 |
Hydrophobic | TM6 | A | 322 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM7 | F | 383 | 7x56 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | F | 383 | 7x56 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | I | 157 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Polar | TM6 | N | 318 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | N | 318 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | N | 318 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM5 | K | 247 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | K | 247 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | H8 | K | 385 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL3 | W | 261 | - | G.s6h5 | T | 348 | G.s6h5.02 |
Polar | ICL3 | T | 260 | - | G.HG | E | 297 | G.HG.05 |
Hydrophobic | ICL3 | I | 308 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Polar | TM3 | A | 156 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM6 | A | 322 | 6x33 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM2 | T | 89 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | L | 466 | - | H.HB | M | 123 | H.HB.10 |
Van-der-waals | C-term | L | 466 | - | H.HB | M | 123 | H.HB.10 |
Polar | ICL3 | W | 261 | - | G.HG | T | 293 | G.HG.01 |
Hydrophobic | ICL3 | W | 261 | - | G.HG | T | 293 | G.HG.01 |
Van-der-waals | ICL3 | W | 261 | - | G.HG | T | 293 | G.HG.01 |
Hydrophobic | TM5 | L | 244 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | I | 161 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | ICL3 | G | 309 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | ICL3 | T | 307 | - | G.S6 | F | 346 | G.S6.05 |
Van-der-waals | ICL3 | T | 307 | - | G.S6 | F | 346 | G.S6.05 |
Ionic | ICL3 | K | 311 | - | G.H5 | D | 364 | G.H5.13 |
Polar | ICL3 | K | 311 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | ICL3 | K | 311 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | ICL3 | K | 311 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | C-term | L | 461 | - | H.hahb | H | 107 | H.hahb.01 |
Van-der-waals | C-term | L | 461 | - | H.hahb | H | 107 | H.hahb.01 |
Hydrophobic | ICL3 | W | 261 | - | G.HG | E | 297 | G.HG.05 |
Van-der-waals | ICL3 | W | 261 | - | G.HG | E | 297 | G.HG.05 |
Hydrophobic | TM6 | L | 326 | 6x37 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL3 | W | 261 | - | G.H4 | Q | 323 | G.H4.08 |
Van-der-waals | ICL3 | W | 261 | - | G.H4 | Q | 323 | G.H4.08 |
Hydrophobic | C-term | R | 409 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | R | 409 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | L | 461 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | L | 461 | - | H.HA | K | 105 | H.HA.28 |
Polar | TM3 | K | 158 | 3x55 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL3 | I | 308 | - | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | ICL3 | W | 261 | - | G.s6h5 | T | 347 | G.s6h5.01 |
Van-der-waals | ICL3 | W | 261 | - | G.s6h5 | T | 347 | G.s6h5.01 |
Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Polar | ICL3 | T | 307 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | ICL3 | T | 307 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ICL3 | T | 307 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | ICL2 | P | 160 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | P | 160 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL2 | N | 164 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | N | 164 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | C-term | D | 462 | - | H.HA | K | 105 | H.HA.28 |
Polar | ICL2 | N | 164 | 34x54 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | N | 164 | 34x54 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | N | 164 | 34x54 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM6 | T | 315 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | T | 315 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | N | 318 | 6x29 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM6 | N | 318 | 6x29 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL1 | Q | 86 | 12x51 | G.HN | F | 4 | G.HN.04 |
Van-der-waals | ICL1 | Q | 86 | 12x51 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | TM3 | A | 156 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | A | 156 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Polar | TM3 | R | 153 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 153 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | R | 153 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM4 | R | 169 | 4x39 | G.HN | F | 4 | G.HN.04 |
Van-der-waals | TM4 | R | 169 | 4x39 | G.HN | F | 4 | G.HN.04 |