G12 - 5-HT2C receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 152 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 159 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 159 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 E 306 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 E 306 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM5 L 241 5x65 G.H5 L 375 G.H5.20
Hydrophobic C-term N 414 - G.H3 K 284 G.H3.16
Hydrophobic ICL2 F 165 34x56 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 F 165 34x56 G.hns1 R 56 G.hns1.03
Polar TM6 A 302 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 A 302 6x26 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 I 160 34x51 G.H5 I 370 G.H5.15
Hydrophobic C-term N 412 - G.H3 K 284 G.H3.16
Hydrophobic TM6 K 308 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 308 6x32 G.H5 M 379 G.H5.24
Polar TM6 E 306 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 E 306 6x30 G.H5 Q 372 G.H5.17
Hydrophobic ICL3 H 252 - G.S6 H 348 G.S6.03
Hydrophobic ICL2 P 159 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 159 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM3 I 156 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 E 161 34x52 G.S3 I 221 G.S3.01
Polar ICL2 R 164 34x55 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 164 34x55 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 164 34x55 G.S1 V 58 G.S1.02
Hydrophobic TM6 Q 301 6x25 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 Q 301 6x25 G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 I 160 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 S 163 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL2 I 160 34x51 G.S1 V 58 G.S1.02
Hydrophobic H8 K 373 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 373 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM6 A 309 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 309 6x33 G.H5 M 379 G.H5.24
Polar ICL2 N 166 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 N 166 34x57 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 N 166 34x57 G.hns1 R 55 G.hns1.02
Polar C-term R 409 - G.h4s6 R 340 G.h4s6.09
Polar ICL3 G 298 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 G 298 - G.h4s6 R 342 G.h4s6.11
Polar TM6 N 305 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 N 305 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM7 F 371 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 F 371 7x56 G.H5 M 379 G.H5.24
Hydrophobic ICL2 I 160 34x51 G.H5 F 363 G.H5.08
Hydrophobic C-term E 410 - G.h4s6 R 340 G.h4s6.09
Hydrophobic TM2 L 92 2x43 G.H5 L 380 G.H5.25
Hydrophobic H8 N 372 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 372 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM6 A 309 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM7 F 371 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 371 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL3 G 298 - G.h4s6 S 343 G.h4s6.12
Polar TM5 Q 244 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 Q 244 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 Q 244 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM7 Y 368 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 368 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM6 K 308 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 308 6x32 G.H5 Q 381 G.H5.26
Polar ICL2 R 164 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 R 164 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 164 34x55 G.hns1 R 55 G.hns1.02
Polar C-term V 413 - G.H3 K 284 G.H3.16
Hydrophobic C-term V 413 - G.H3 K 284 G.H3.16
Van-der-waals C-term V 413 - G.H3 K 284 G.H3.16
Hydrophobic TM4 S 167 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 I 160 34x51 G.H5 V 366 G.H5.11
Polar ICL3 G 298 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 G 298 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 A 155 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 I 160 34x51 G.S3 I 221 G.S3.01
Polar ICL2 P 159 34x50 G.H5 N 374 G.H5.19
Hydrophobic TM6 L 313 6x37 G.H5 I 378 G.H5.23
Polar H8 N 372 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 372 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 372 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 R 164 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 164 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic C-term L 411 - G.H2 Q 236 G.H2.05
Hydrophobic ICL3 T 299 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 I 156 3x54 G.H5 L 375 G.H5.20
Polar ICL2 R 164 34x55 G.S1 L 57 G.S1.01
Hydrophobic ICL2 R 164 34x55 G.S1 L 57 G.S1.01
Van-der-waals ICL2 R 164 34x55 G.S1 L 57 G.S1.01
Hydrophobic TM6 N 305 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 N 305 6x29 G.H5 M 379 G.H5.24
Hydrophobic H8 Y 375 8x50 G.H5 L 380 G.H5.25
Polar TM3 A 155 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 155 3x53 G.H5 N 374 G.H5.19
Hydrophobic C-term I 415 - G.H3 K 284 G.H3.16
Van-der-waals C-term I 415 - G.H3 K 284 G.H3.16
Hydrophobic TM3 I 156 3x54 G.H5 L 371 G.H5.16
Polar TM3 R 157 3x55 G.H5 K 367 G.H5.12
Ionic C-term H 418 - G.h2s4 D 243 G.h2s4.02
Polar C-term H 418 - G.h2s4 D 243 G.h2s4.02
Hydrophobic C-term H 418 - G.h2s4 D 243 G.h2s4.02
Hydrophobic TM5 Q 244 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 159 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL3 G 298 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 G 298 - G.h4s6 K 344 G.h4s6.19