Gz - 5-HT5A receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 F 268 - G.H4 Q 307 G.H4.14
Hydrophobic ICL2 T 150 34x54 G.s2s3 E 194 G.s2s3.02
Hydrophobic TM3 I 135 3x46 G.H5 L 354 G.H5.25
Van-der-waals TM3 I 135 3x46 G.H5 L 354 G.H5.25
Hydrophobic TM4 L 151 4x35 G.H5 I 352 G.H5.23
Polar ICL3 E 244 - G.hgh4 G 293 G.hgh4.07
Hydrophobic ICL3 E 244 - G.hgh4 G 293 G.hgh4.07
Van-der-waals ICL3 E 244 - G.hgh4 G 293 G.hgh4.07
Polar ICL2 H 146 34x50 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 H 146 34x50 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 H 146 34x50 G.s2s3 K 193 G.s2s3.01
Polar H8 N 342 8x47 G.H5 C 355 G.H5.26
Van-der-waals H8 N 342 8x47 G.H5 C 355 G.H5.26
Polar ICL3 E 244 - G.H4 E 299 G.H4.05
Van-der-waals ICL3 E 244 - G.H4 E 299 G.H4.05
Polar ICL2 T 150 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 150 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 150 34x54 G.hns1 R 32 G.hns1.03
Polar TM2 H 76 2x40 G.H5 Y 351 G.H5.22
Polar TM4 R 154 4x38 G.H5 N 348 G.H5.19
Polar TM3 R 139 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM3 R 139 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 139 3x50 G.H5 L 354 G.H5.25
Hydrophobic ICL3 E 244 - G.hgh4 Y 291 G.hgh4.05
Van-der-waals ICL3 E 244 - G.hgh4 Y 291 G.hgh4.05
Ionic ICL2 H 146 34x50 G.H5 D 342 G.H5.13
Polar ICL2 H 146 34x50 G.H5 D 342 G.H5.13
Hydrophobic ICL2 H 146 34x50 G.H5 D 342 G.H5.13
Van-der-waals ICL2 H 146 34x50 G.H5 D 342 G.H5.13
Polar ICL3 T 267 - G.H4 E 299 G.H4.05
Polar ICL3 S 243 - G.H4 E 299 G.H4.05
Hydrophobic ICL3 S 243 - G.H4 E 299 G.H4.05
Van-der-waals ICL3 S 243 - G.H4 E 299 G.H4.05
Polar ICL3 A 245 - G.H4 E 299 G.H4.05
Hydrophobic ICL3 A 245 - G.H4 E 299 G.H4.05
Van-der-waals ICL3 A 245 - G.H4 E 299 G.H4.05
Polar ICL3 Q 269 - G.H4 R 306 G.H4.13
Van-der-waals ICL3 Q 269 - G.H4 R 306 G.H4.13
Hydrophobic ICL3 A 245 - G.H4 Y 303 G.H4.10
Van-der-waals ICL3 A 245 - G.H4 Y 303 G.H4.10
Hydrophobic ICL2 M 147 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 M 147 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic TM3 S 142 3x53 G.H5 L 349 G.H5.20
Van-der-waals TM3 S 142 3x53 G.H5 L 349 G.H5.20
Hydrophobic H8 N 342 8x47 G.H5 G 353 G.H5.24
Polar ICL3 S 243 - G.hgh4 Q 294 G.hgh4.08
Hydrophobic ICL3 S 243 - G.hgh4 Q 294 G.hgh4.08
Van-der-waals ICL3 S 243 - G.hgh4 Q 294 G.hgh4.08
Polar ICL3 A 245 - G.hgh4 Y 291 G.hgh4.05
Hydrophobic ICL3 A 245 - G.hgh4 Y 291 G.hgh4.05
Van-der-waals ICL3 A 245 - G.hgh4 Y 291 G.hgh4.05
Polar ICL3 T 267 - G.hgh4 K 292 G.hgh4.06
Hydrophobic ICL3 S 240 - G.H4 E 298 G.H4.04
Van-der-waals ICL3 S 240 - G.H4 E 298 G.H4.04
Hydrophobic ICL2 E 148 34x52 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 E 148 34x52 G.s2s3 E 194 G.s2s3.02
Polar ICL3 E 244 - G.H4 N 295 G.H4.01
Hydrophobic ICL3 E 244 - G.H4 N 295 G.H4.01
Van-der-waals ICL3 E 244 - G.H4 N 295 G.H4.01
Polar H8 K 343 8x48 G.h4s6 E 316 G.h4s6.09
Van-der-waals H8 K 343 8x48 G.h4s6 E 316 G.h4s6.09
Hydrophobic ICL3 P 241 - G.H4 E 298 G.H4.04
Van-der-waals ICL3 P 241 - G.H4 E 298 G.H4.04
Hydrophobic ICL2 M 147 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 M 147 34x51 G.H5 T 341 G.H5.12
Polar ICL3 I 242 - G.H4 T 296 G.H4.02
Hydrophobic ICL3 I 242 - G.H4 T 296 G.H4.02
Van-der-waals ICL3 I 242 - G.H4 T 296 G.H4.02
Hydrophobic ICL3 S 243 - G.hgh4 G 293 G.hgh4.07
Van-der-waals ICL3 S 243 - G.hgh4 G 293 G.hgh4.07
Aromatic ICL3 F 268 - G.H4 Y 303 G.H4.10
Hydrophobic ICL3 F 268 - G.H4 Y 303 G.H4.10
Van-der-waals ICL3 F 268 - G.H4 Y 303 G.H4.10
Hydrophobic ICL2 M 147 34x51 G.S2 F 192 G.S2.08
Van-der-waals ICL2 M 147 34x51 G.S2 F 192 G.S2.08
Polar TM4 R 152 4x36 G.HN Q 28 G.HN.52
Hydrophobic TM4 R 152 4x36 G.HN Q 28 G.HN.52
Van-der-waals TM4 R 152 4x36 G.HN Q 28 G.HN.52
Hydrophobic TM2 P 75 2x39 G.H5 L 354 G.H5.25
Van-der-waals TM2 P 75 2x39 G.H5 L 354 G.H5.25
Hydrophobic TM4 L 151 4x35 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 L 151 4x35 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 M 147 34x51 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 M 147 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 M 147 34x51 G.S3 L 195 G.S3.01
Polar ICL3 I 242 - G.H4 E 299 G.H4.05
Hydrophobic ICL3 I 242 - G.H4 E 299 G.H4.05
Van-der-waals ICL3 I 242 - G.H4 E 299 G.H4.05
Hydrophobic H8 Y 345 8x50 G.H5 G 353 G.H5.24
Hydrophobic TM2 V 74 2x38 G.H5 I 352 G.H5.23
Van-der-waals TM2 V 74 2x38 G.H5 I 352 G.H5.23
Polar H8 N 342 8x47 G.H5 K 350 G.H5.21
Van-der-waals H8 N 342 8x47 G.H5 K 350 G.H5.21
Hydrophobic TM4 R 152 4x36 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 R 152 4x36 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 M 147 34x51 G.H5 I 345 G.H5.16
Van-der-waals ICL2 M 147 34x51 G.H5 I 345 G.H5.16
Polar TM4 T 153 4x37 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 153 4x37 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 D 138 3x49 G.H5 L 354 G.H5.25
Van-der-waals TM3 D 138 3x49 G.H5 L 354 G.H5.25
Ionic TM5 R 230 5x68 G.H5 D 342 G.H5.13
Polar TM5 R 230 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 R 230 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 230 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM2 H 76 2x40 G.H5 G 353 G.H5.24
Polar H8 N 344 8x49 G.H5 Y 351 G.H5.22
Hydrophobic H8 N 344 8x49 G.H5 Y 351 G.H5.22
Van-der-waals H8 N 344 8x49 G.H5 Y 351 G.H5.22
Hydrophobic ICL3 V 239 - G.H4 E 298 G.H4.04
Van-der-waals ICL3 V 239 - G.H4 E 298 G.H4.04
Hydrophobic ICL2 H 146 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM4 R 154 4x38 G.H5 L 349 G.H5.20
Van-der-waals TM4 R 154 4x38 G.H5 L 349 G.H5.20
Hydrophobic ICL3 P 241 - G.H4 E 299 G.H4.05
Van-der-waals ICL3 P 241 - G.H4 E 299 G.H4.05
Hydrophobic ICL3 F 268 - G.H4 V 302 G.H4.08
Polar ICL3 E 244 - G.hgh4 K 292 G.hgh4.06
Hydrophobic ICL3 E 244 - G.hgh4 K 292 G.hgh4.06
Van-der-waals ICL3 E 244 - G.hgh4 K 292 G.hgh4.06
Polar TM2 P 75 2x39 G.H5 I 352 G.H5.23
Hydrophobic TM2 P 75 2x39 G.H5 I 352 G.H5.23
Van-der-waals TM2 P 75 2x39 G.H5 I 352 G.H5.23
Polar ICL3 F 268 - G.H4 R 306 G.H4.13
Hydrophobic ICL3 F 268 - G.H4 R 306 G.H4.13
Van-der-waals ICL3 F 268 - G.H4 R 306 G.H4.13
Polar TM2 H 76 2x40 G.H5 I 352 G.H5.23
Hydrophobic TM2 H 76 2x40 G.H5 I 352 G.H5.23
Van-der-waals TM2 H 76 2x40 G.H5 I 352 G.H5.23
Ionic TM6 K 279 6x29 G.h4s6 E 319 G.h4s6.12
Polar TM6 K 279 6x29 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 K 279 6x29 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 A 245 - G.H4 A 300 G.H4.06
Van-der-waals ICL3 A 245 - G.H4 A 300 G.H4.06
Polar ICL3 E 244 - G.hgh4 Q 294 G.hgh4.08
Hydrophobic ICL3 E 244 - G.hgh4 Q 294 G.hgh4.08
Van-der-waals ICL3 E 244 - G.hgh4 Q 294 G.hgh4.08
Hydrophobic ICL3 I 242 - G.H4 E 298 G.H4.04
Van-der-waals ICL3 I 242 - G.H4 E 298 G.H4.04
Hydrophobic TM2 R 73 2x37 G.H5 I 352 G.H5.23
Van-der-waals TM2 R 73 2x37 G.H5 I 352 G.H5.23
Hydrophobic ICL2 T 150 34x54 G.S3 L 195 G.S3.01