Ggust -
5-HT6 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | TM6 | K | 258 | 6x25 | G.h4s6 | E | 315 | G.h4s6.09 |
Polar | TM6 | K | 258 | 6x25 | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | TM6 | K | 258 | 6x25 | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | TM6 | K | 258 | 6x25 | G.h4s6 | E | 315 | G.h4s6.09 |
Ionic | ICL3 | D | 251 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Polar | ICL3 | D | 251 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | ICL3 | D | 251 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Polar | C-term | L | 399 | - | H.HA | Q | 79 | H.HA.17 |
Hydrophobic | C-term | A | 396 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Aromatic | C-term | F | 421 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | F | 421 | - | G.H3 | H | 256 | G.H3.15 |
Van-der-waals | C-term | F | 421 | - | G.H3 | H | 256 | G.H3.15 |
Polar | TM6 | A | 266 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 266 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | A | 266 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | S | 389 | - | H.HA | Q | 64 | H.HA.02 |
Hydrophobic | TM5 | V | 222 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | V | 222 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | L | 392 | - | H.HA | E | 65 | H.HA.03 |
Van-der-waals | C-term | L | 392 | - | H.HA | E | 65 | H.HA.03 |
Polar | H8 | R | 325 | 8x48 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL3 | M | 229 | - | G.S6 | I | 319 | G.S6.01 |
Polar | C-term | L | 392 | - | H.HA | E | 68 | H.HA.06 |
Hydrophobic | C-term | L | 392 | - | H.HA | E | 68 | H.HA.06 |
Van-der-waals | C-term | L | 392 | - | H.HA | E | 68 | H.HA.06 |
Polar | TM3 | L | 127 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | L | 127 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | L | 127 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM6 | K | 262 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 262 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL3 | M | 229 | - | G.H4 | L | 308 | G.H4.16 |
Van-der-waals | ICL3 | M | 229 | - | G.H4 | L | 308 | G.H4.16 |
Polar | TM6 | K | 262 | 6x29 | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | TM6 | K | 262 | 6x29 | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | C-term | L | 400 | - | H.hbhc | D | 116 | H.hbhc.04 |
Polar | TM6 | K | 265 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 265 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 265 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | F | 421 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | TM5 | L | 225 | 5x75 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | L | 398 | - | H.HA | S | 75 | H.HA.13 |
Van-der-waals | C-term | L | 398 | - | H.HA | S | 75 | H.HA.13 |
Hydrophobic | C-term | L | 399 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | C-term | F | 421 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | F | 421 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | TM5 | I | 211 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | I | 211 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | L | 394 | - | H.HA | F | 69 | H.HA.07 |
Hydrophobic | TM3 | I | 128 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL3 | S | 231 | - | G.H4 | D | 309 | G.H4.17 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 131 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM5 | A | 219 | 5x69 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL3 | L | 255 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | TM3 | I | 128 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | T | 269 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 269 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Polar | TM5 | Q | 218 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | Q | 218 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | Q | 218 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | ICL2 | K | 135 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | K | 135 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | K | 135 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | L | 398 | - | H.hbhc | D | 116 | H.hbhc.04 |
Van-der-waals | C-term | L | 398 | - | H.hbhc | D | 116 | H.hbhc.04 |
Hydrophobic | TM5 | L | 225 | 5x75 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM5 | L | 225 | 5x75 | G.S6 | Y | 320 | G.S6.02 |
Polar | ICL2 | K | 135 | 34x54 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | K | 135 | 34x54 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM6 | K | 265 | 6x32 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM5 | A | 215 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | L | 255 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Polar | ICL2 | K | 135 | 34x54 | G.HN | A | 27 | G.HN.51 |
Polar | TM7 | F | 323 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM7 | F | 323 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | F | 323 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | L | 270 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 270 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Ionic | TM6 | K | 258 | 6x25 | G.h4s6 | D | 316 | G.h4s6.10 |
Polar | TM6 | K | 258 | 6x25 | G.h4s6 | D | 316 | G.h4s6.10 |
Van-der-waals | TM6 | K | 258 | 6x25 | G.h4s6 | D | 316 | G.h4s6.10 |
Hydrophobic | C-term | F | 420 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | F | 420 | - | G.H2 | R | 208 | G.H2.04 |
Ionic | ICL2 | R | 133 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | R | 133 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 133 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | K | 135 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | K | 135 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | K | 135 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Ionic | ICL3 | R | 254 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Polar | ICL3 | R | 254 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | TM3 | R | 124 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | L | 127 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | L | 394 | - | H.HA | E | 68 | H.HA.06 |
Van-der-waals | ICL3 | G | 228 | - | G.H4 | N | 305 | G.H4.13 |
Hydrophobic | TM5 | Q | 218 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | Q | 218 | 5x68 | G.H5 | L | 348 | G.H5.20 |
Polar | TM5 | Q | 221 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | Q | 221 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | Q | 221 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM3 | I | 128 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Polar | TM6 | T | 269 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | T | 269 | 6x36 | G.H5 | G | 352 | G.H5.24 |