Gz - 5-HT6 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 10.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM5 Q 218 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 Q 218 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 Q 218 5x68 G.H5 D 342 G.H5.13
Polar ICL2 R 133 34x52 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 R 133 34x52 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 R 133 34x52 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 L 132 34x51 G.S3 F 197 G.S3.03
Hydrophobic ICL2 P 131 34x50 G.H5 T 341 G.H5.12
Van-der-waals TM6 K 262 6x29 G.H5 Q 346 G.H5.17
Hydrophobic H8 M 324 8x47 G.H5 I 352 G.H5.23
Polar TM6 A 266 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 266 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 266 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM4 T 139 4x38 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 T 139 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic TM5 I 211 5x61 G.H5 I 352 G.H5.23
Hydrophobic TM3 L 127 3x53 G.H5 I 352 G.H5.23
Hydrophobic TM5 Q 218 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 Q 218 5x68 G.H5 I 345 G.H5.16
Hydrophobic H8 M 324 8x47 G.H5 Y 351 G.H5.22
Ionic ICL2 R 133 34x52 G.s2s3 E 194 G.s2s3.02
Polar ICL2 R 133 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic TM5 I 211 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 I 211 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM5 I 211 5x61 G.H5 L 349 G.H5.20
Polar ICL3 Q 232 - G.H4 E 299 G.H4.05
Hydrophobic TM6 T 269 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 269 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM5 L 225 5x75 G.S6 H 323 G.S6.04
Polar TM5 Q 221 5x71 G.H5 D 342 G.H5.13
Hydrophobic TM5 Q 221 5x71 G.H5 D 342 G.H5.13
Van-der-waals TM5 Q 221 5x71 G.H5 D 342 G.H5.13
Hydrophobic ICL3 M 229 - G.H4 V 302 G.H4.08
Van-der-waals ICL3 M 229 - G.H4 V 302 G.H4.08
Polar TM6 T 269 6x36 G.H5 G 353 G.H5.24
Hydrophobic TM6 T 269 6x36 G.H5 G 353 G.H5.24
Ionic H8 R 325 8x48 G.h4s6 E 316 G.h4s6.09
Polar H8 R 325 8x48 G.h4s6 E 316 G.h4s6.09
Hydrophobic H8 R 325 8x48 G.h4s6 E 316 G.h4s6.09
Van-der-waals H8 R 325 8x48 G.h4s6 E 316 G.h4s6.09
Hydrophobic TM3 R 124 3x50 G.H5 I 352 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 132 34x51 G.H5 I 344 G.H5.15
Hydrophobic ICL2 K 135 34x54 G.hns1 R 31 G.hns1.02
Ionic TM6 K 262 6x29 G.h4s6 E 319 G.h4s6.12
Polar TM6 K 262 6x29 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 K 262 6x29 G.h4s6 E 319 G.h4s6.12
Hydrophobic C-term V 369 - G.H3 R 249 G.H3.07
Van-der-waals C-term V 369 - G.H3 R 249 G.H3.07
Hydrophobic TM3 I 128 3x54 G.H5 I 345 G.H5.16
Hydrophobic H8 R 325 8x48 G.h4s6 T 317 G.h4s6.10
Van-der-waals H8 R 325 8x48 G.h4s6 T 317 G.h4s6.10
Hydrophobic TM3 I 128 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 128 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL3 M 229 - G.H4 Q 305 G.H4.12
Van-der-waals ICL3 M 229 - G.H4 Q 305 G.H4.12
Van-der-waals ICL2 L 132 34x51 G.H5 T 341 G.H5.12
Polar TM3 L 127 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 L 127 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 L 127 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM5 A 215 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM3 L 127 3x53 G.H5 Y 351 G.H5.22
Van-der-waals ICL2 P 131 34x50 G.H5 N 348 G.H5.19
Polar TM2 N 62 2x40 G.H5 Y 351 G.H5.22
Van-der-waals TM2 N 62 2x40 G.H5 Y 351 G.H5.22
Hydrophobic TM3 I 128 3x54 G.H5 I 352 G.H5.23
Polar TM2 N 59 2x37 G.H5 Y 351 G.H5.22
Van-der-waals TM2 N 59 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM4 P 140 4x39 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 P 140 4x39 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 L 132 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 132 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM5 V 222 5x72 G.S6 Y 321 G.S6.02
Hydrophobic ICL3 M 229 - G.H4 A 301 G.H4.07
Hydrophobic ICL2 L 136 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 136 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic H8 D 326 8x49 G.H5 Y 351 G.H5.22
Van-der-waals H8 D 326 8x49 G.H5 Y 351 G.H5.22
Polar TM6 K 265 6x32 G.H5 C 355 G.H5.26
Hydrophobic TM6 K 265 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 K 265 6x32 G.H5 C 355 G.H5.26
Hydrophobic ICL2 P 131 34x50 G.H5 I 345 G.H5.16
Hydrophobic ICL2 R 133 34x52 G.S3 L 195 G.S3.01
Hydrophobic TM6 L 270 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 270 6x37 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 132 34x51 G.S1 I 34 G.S1.02
Ionic ICL3 D 251 - G.H4 R 306 G.H4.13
Polar ICL3 D 251 - G.H4 R 306 G.H4.13
Hydrophobic ICL3 D 251 - G.H4 R 306 G.H4.13
Van-der-waals ICL3 D 251 - G.H4 R 306 G.H4.13
Polar TM7 F 323 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM7 F 323 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 F 323 7x56 G.H5 G 353 G.H5.24
Hydrophobic ICL3 M 229 - G.S6 F 324 G.S6.05
Van-der-waals ICL3 M 229 - G.S6 F 324 G.S6.05
Hydrophobic ICL2 P 131 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 131 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM3 I 128 3x54 G.H5 N 348 G.H5.19
Van-der-waals TM3 I 128 3x54 G.H5 N 348 G.H5.19
Hydrophobic TM5 Q 218 5x68 G.H5 L 349 G.H5.20