G12 - A1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 14.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 K 228 6x29 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 R 114 34x52 G.S3 I 221 G.S3.01
Hydrophobic ICL2 M 117 34x55 G.S3 I 221 G.S3.01
Hydrophobic ICL2 M 117 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 M 117 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 I 232 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 I 232 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM5 Q 210 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 Q 210 5x68 G.H5 L 371 G.H5.16
Polar H8 I 292 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 I 292 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 I 292 8x47 G.H5 L 380 G.H5.25
Polar TM3 R 105 3x50 G.H5 D 377 G.H5.22
Hydrophobic ICL2 L 113 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 M 117 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 M 117 34x55 G.s2s3 K 220 G.s2s3.02
Ionic TM5 K 214 5x72 G.H5 D 368 G.H5.13
Polar TM5 K 214 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 214 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM3 V 109 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 109 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 E 229 6x30 G.H5 M 379 G.H5.24
Van-der-waals TM6 E 229 6x30 G.H5 M 379 G.H5.24
Polar ICL2 K 116 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 K 116 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 K 116 34x54 G.hns1 R 55 G.hns1.02
Polar TM6 Y 225 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Y 225 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Y 225 6x26 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 P 112 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 113 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL3 S 218 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 M 117 34x55 G.S3 P 222 G.S3.02
Hydrophobic TM5 K 214 5x72 G.S6 F 347 G.S6.02
Hydrophobic TM5 I 207 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 I 207 5x65 G.H5 L 375 G.H5.20
Polar ICL1 R 41 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 K 214 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 K 214 5x72 G.H5 Q 372 G.H5.17
Ionic H8 K 294 8x49 G.H5 D 377 G.H5.22
Polar H8 K 294 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 K 294 8x49 G.H5 D 377 G.H5.22
Hydrophobic TM6 I 232 6x33 G.H5 Q 381 G.H5.26
Van-der-waals TM6 I 232 6x33 G.H5 Q 381 G.H5.26
Polar ICL2 K 116 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 116 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 R 105 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 105 3x50 G.H5 I 378 G.H5.23
Ionic TM3 R 108 3x53 G.H5 D 377 G.H5.22
Polar TM3 R 108 3x53 G.H5 D 377 G.H5.22
Hydrophobic TM3 R 108 3x53 G.H5 D 377 G.H5.22
Van-der-waals TM3 R 108 3x53 G.H5 D 377 G.H5.22
Hydrophobic TM7 R 291 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 R 291 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM3 R 108 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 108 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM6 L 236 6x37 G.H5 I 378 G.H5.23
Hydrophobic TM4 T 120 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 120 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 112 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 E 229 6x30 G.H5 L 375 G.H5.20
Polar TM3 R 108 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 R 108 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 R 108 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 113 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 113 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM3 V 109 3x54 G.H5 L 375 G.H5.20
Polar H8 Q 293 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 Q 293 8x48 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 113 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 113 34x51 G.H5 I 370 G.H5.15
Hydrophobic H8 Q 293 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 Q 293 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM3 V 109 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 109 3x54 G.H5 L 371 G.H5.16
Polar TM5 Q 210 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 Q 210 5x68 G.H5 D 368 G.H5.13
Hydrophobic ICL2 L 113 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 113 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 P 112 34x50 G.H5 L 371 G.H5.16