Gs - A2A receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM5 Q 207 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 207 5x68 G.H5 Q 384 G.H5.16
Polar ICL2 N 113 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 N 113 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 N 113 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 P 109 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 L 216 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 A 204 5x65 G.H5 L 388 G.H5.20
Polar TM5 Q 207 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 207 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 207 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL3 P 217 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 P 217 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 L 110 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL2 G 114 34x55 G.hns1 A 39 G.hns1.03
Ionic ICL2 R 111 34x52 G.s2s3 D 215 G.s2s3.01
Polar ICL2 R 111 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 R 111 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 111 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 R 111 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 111 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM6 S 234 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 106 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 105 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 A 203 5x64 G.H5 L 388 G.H5.20
Polar TM3 A 105 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 105 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 105 3x53 G.H5 H 387 G.H5.19
Ionic H8 R 296 8x51 G.H5 E 392 G.H5.24
Polar H8 R 296 8x51 G.H5 E 392 G.H5.24
Hydrophobic H8 R 296 8x51 G.H5 E 392 G.H5.24
Van-der-waals H8 R 296 8x51 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 109 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 110 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 110 34x51 G.H5 F 376 G.H5.08
Ionic C-term E 332 - G.H3 K 274 G.H3.10
Polar C-term E 332 - G.H3 K 274 G.H3.10
Hydrophobic C-term E 332 - G.H3 K 274 G.H3.10
Van-der-waals C-term E 332 - G.H3 K 274 G.H3.10
Hydrophobic TM3 I 106 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM7 R 291 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 R 291 7x56 G.H5 E 392 G.H5.24
Polar H8 R 293 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 R 293 8x48 G.H5 E 392 G.H5.24
Polar C-term L 324 - G.h3s5 R 283 G.h3s5.01
Hydrophobic C-term L 324 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term L 324 - G.h3s5 R 283 G.h3s5.01
Aromatic TM3 R 102 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 102 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 102 3x50 G.H5 Y 391 G.H5.23
Aromatic ICL2 Y 112 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 112 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 L 235 6x37 G.H5 L 393 G.H5.25
Polar TM6 H 230 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 200 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 109 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 109 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 110 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 110 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 110 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL2 R 111 34x52 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 M 211 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 M 211 5x72 G.h4s6 Y 358 G.h4s6.20
Polar TM5 Q 207 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 Q 207 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 Q 207 5x68 G.H5 D 381 G.H5.13
Hydrophobic C-term L 338 - G.s4h3 D 260 G.s4h3.11
Van-der-waals C-term L 338 - G.s4h3 D 260 G.s4h3.11
Polar TM3 I 106 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 106 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 106 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 106 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 106 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL3 L 216 - G.h4s6 G 353 G.h4s6.09
Hydrophobic TM6 A 231 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM5 M 211 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM5 M 211 5x72 G.H5 L 394 G.H5.26
Hydrophobic TM5 Q 207 5x68 G.H5 L 394 G.H5.26
Polar ICL3 Q 214 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 Q 214 - G.S6 C 359 G.S6.01
Hydrophobic ICL2 L 110 34x51 G.S3 F 219 G.S3.03
Hydrophobic ICL2 N 113 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic ICL3 P 217 - G.h4s6 A 351 G.h4s6.04
Hydrophobic C-term L 324 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term L 324 - G.h4s6 R 356 G.h4s6.12
Hydrophobic ICL2 L 110 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM4 T 117 4x38 G.HN Q 35 G.HN.52
Polar ICL2 L 110 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 110 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 110 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 P 109 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 109 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 L 208 5x69 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 208 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 Q 207 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 Q 207 5x68 G.H5 L 388 G.H5.20