Gi1 - A3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 E 217 6x22 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 E 217 6x22 G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 R 120 34x55 G.hns1 R 32 G.hns1.03
Polar TM6 S 231 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 S 231 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL2 T 115 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 T 115 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 K 207 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 207 5x68 G.H5 I 344 G.H5.16
Ionic TM6 R 224 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 224 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 224 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM5 N 211 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM5 N 211 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM5 I 204 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 204 5x65 G.H5 L 348 G.H5.20
Polar TM3 R 108 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 108 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 108 3x50 G.H5 C 351 G.H5.23
Polar TM3 R 111 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 111 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 111 3x53 G.H5 C 351 G.H5.23
Hydrophobic H8 I 286 8x47 G.H5 G 352 G.H5.24
Polar TM3 R 111 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 111 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 111 3x53 G.H5 N 347 G.H5.19
Polar TM6 R 224 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 224 6x29 G.h4s6 D 315 G.h4s6.09
Polar TM6 T 228 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 228 6x33 G.H5 L 353 G.H5.25
Aromatic TM4 H 124 4x39 G.HN R 24 G.HN.48
Ionic ICL2 R 117 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 117 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 117 34x52 G.s2s3 D 193 G.s2s3.02
Ionic ICL2 R 120 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 120 34x55 G.s2s3 D 193 G.s2s3.02
Polar TM6 K 227 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 227 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 227 6x32 G.H5 F 354 G.H5.26
Ionic H8 K 288 8x49 G.H5 D 350 G.H5.22
Polar H8 K 288 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 288 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM7 K 285 7x56 G.H5 G 352 G.H5.24
Polar TM5 N 211 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 N 211 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 N 211 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM6 S 231 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 116 34x51 G.H5 I 343 G.H5.15
Polar ICL2 T 115 34x50 G.H5 N 347 G.H5.19
Hydrophobic H8 I 286 8x47 G.H5 C 351 G.H5.23
Polar ICL2 K 119 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 119 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 119 34x54 G.hns1 R 32 G.hns1.03
Polar TM5 N 211 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 N 211 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 A 220 6x25 G.h4s6 D 315 G.h4s6.09
Ionic TM3 R 111 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 232 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 232 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 108 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 112 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 112 3x54 G.H5 L 348 G.H5.20
Hydrophobic H8 I 286 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 I 286 8x47 G.H5 D 350 G.H5.22
Hydrophobic ICL2 T 115 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 T 115 34x50 G.H5 I 344 G.H5.16
Polar ICL2 K 119 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 K 119 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 119 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 R 224 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 116 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 116 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 I 200 5x61 G.H5 L 353 G.H5.25