G15 -
M1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 88.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 10.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | K | 362 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | K | 362 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | K | 362 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL2 | L | 131 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | C-term | P | 449 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | ICL2 | R | 134 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | R | 134 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Polar | ICL2 | R | 137 | 34x57 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | R | 137 | 34x57 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | R | 137 | 34x57 | G.hns1 | R | 40 | G.hns1.02 |
Ionic | TM5 | E | 221 | 5x71 | G.H5 | R | 360 | G.H5.12 |
Polar | TM5 | E | 221 | 5x71 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM6 | K | 362 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM7 | C | 421 | 7x56 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | R | 134 | 34x54 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | ICL2 | L | 131 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM6 | V | 358 | 6x28 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM6 | L | 367 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Polar | TM6 | F | 355 | 6x25 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | F | 355 | 6x25 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | TM7 | C | 421 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM7 | C | 421 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | C | 421 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | P | 446 | - | G.H3 | P | 265 | G.H3.16 |
Polar | TM6 | L | 357 | 6x27 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | L | 357 | 6x27 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | L | 357 | 6x27 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | TM3 | D | 122 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | V | 127 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | V | 358 | 6x28 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL2 | L | 131 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | ICL2 | A | 135 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | TM6 | K | 362 | 6x32 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | H | 453 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | H | 453 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | H | 453 | - | G.H2 | R | 216 | G.H2.04 |
Polar | TM3 | S | 126 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | S | 126 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | S | 126 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM5 | L | 222 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | R | 218 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM5 | R | 218 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Polar | H8 | N | 422 | 8x47 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | H8 | N | 422 | 8x47 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | H8 | N | 422 | 8x47 | G.H5 | E | 370 | G.H5.22 |
Polar | TM6 | T | 366 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM2 | V | 59 | 2x38 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | TM2 | V | 59 | 2x38 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM3 | V | 127 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM6 | F | 355 | 6x25 | G.h4s6 | T | 321 | G.h4s6.03 |
Hydrophobic | TM6 | L | 357 | 6x27 | G.H5 | A | 365 | G.H5.17 |
Hydrophobic | C-term | P | 449 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | P | 449 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | ICL2 | R | 134 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 134 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Polar | TM2 | N | 60 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | N | 60 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM3 | V | 127 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | ICL2 | L | 131 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | L | 131 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Polar | TM6 | A | 363 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | A | 363 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM5 | T | 215 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM4 | P | 139 | 4x39 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | TM4 | P | 139 | 4x39 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM5 | L | 225 | 5x75 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | TM5 | L | 225 | 5x75 | G.H5 | K | 357 | G.H5.09 |
Polar | C-term | H | 453 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | H | 453 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | H | 453 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | ICL2 | L | 131 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | R | 218 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | R | 218 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | L | 357 | 6x27 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | L | 357 | 6x27 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | V | 452 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | TM4 | T | 138 | 4x38 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM2 | N | 60 | 2x39 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM2 | N | 60 | 2x39 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | R | 123 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM6 | T | 366 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | P | 130 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | L | 131 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Polar | TM6 | K | 362 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | K | 362 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | K | 362 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Ionic | ICL3 | E | 229 | - | G.H4 | R | 310 | G.H4.09 |
Polar | ICL3 | E | 229 | - | G.H4 | R | 310 | G.H4.09 |
Van-der-waals | ICL3 | E | 229 | - | G.H4 | R | 310 | G.H4.09 |
Polar | C-term | H | 453 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | C-term | P | 446 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | P | 446 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | TM5 | I | 211 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Polar | TM3 | R | 123 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | R | 123 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | R | 123 | 3x50 | G.H5 | Y | 367 | G.H5.19 |