Gz -
M1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 89.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | K | 444 | - | G.H3 | N | 258 | G.H3.16 |
Ionic | TM6 | K | 359 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM6 | K | 359 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | K | 359 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM6 | K | 362 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM6 | K | 362 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM6 | K | 362 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM5 | L | 222 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Polar | TM3 | S | 126 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | S | 126 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | S | 126 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM5 | L | 225 | 5x75 | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | TM5 | L | 225 | 5x75 | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | P | 130 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | ICL2 | L | 131 | 34x51 | G.S1 | I | 34 | G.S1.02 |
Polar | ICL3 | Q | 226 | - | G.H4 | Q | 305 | G.H4.12 |
Van-der-waals | ICL3 | Q | 226 | - | G.H4 | Q | 305 | G.H4.12 |
Polar | TM6 | A | 363 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | A | 363 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM5 | L | 225 | 5x75 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM5 | L | 225 | 5x75 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | ICL2 | L | 131 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | L | 131 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | ICL3 | T | 230 | - | G.H4 | V | 302 | G.H4.08 |
Hydrophobic | TM6 | L | 367 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM7 | C | 421 | 7x56 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM7 | C | 421 | 7x56 | G.H5 | G | 353 | G.H5.24 |
Polar | H8 | N | 422 | 8x47 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | H8 | N | 422 | 8x47 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | H8 | N | 422 | 8x47 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM5 | L | 222 | 5x72 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM5 | L | 222 | 5x72 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | TM3 | V | 127 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 123 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 123 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | ICL2 | L | 131 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | L | 131 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | L | 131 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 131 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL2 | A | 135 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM5 | T | 215 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Polar | TM6 | T | 366 | 6x36 | G.H5 | G | 353 | G.H5.24 |
Polar | ICL2 | R | 137 | 34x57 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM5 | L | 222 | 5x72 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM5 | L | 222 | 5x72 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | ICL3 | Q | 348 | - | G.H4 | R | 306 | G.H4.13 |
Hydrophobic | ICL3 | Q | 348 | - | G.H4 | R | 306 | G.H4.13 |
Van-der-waals | ICL3 | Q | 348 | - | G.H4 | R | 306 | G.H4.13 |
Polar | TM2 | N | 61 | 2x40 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM2 | N | 61 | 2x40 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | N | 61 | 2x40 | G.H5 | Y | 351 | G.H5.22 |
Polar | TM2 | T | 58 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | T | 58 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM5 | R | 218 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM5 | R | 218 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM7 | C | 421 | 7x56 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM7 | C | 421 | 7x56 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM5 | L | 225 | 5x75 | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | TM3 | V | 127 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | V | 127 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM5 | L | 225 | 5x75 | G.H5 | A | 339 | G.H5.10 |
Hydrophobic | C-term | K | 444 | - | G.h3s5 | I | 261 | G.h3s5.01 |
Van-der-waals | C-term | K | 444 | - | G.h3s5 | I | 261 | G.h3s5.01 |
Van-der-waals | C-term | C | 460 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Polar | ICL3 | G | 227 | - | G.S6 | S | 322 | G.S6.03 |
Van-der-waals | C-term | R | 458 | - | G.H3 | R | 249 | G.H3.07 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | P | 130 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Polar | TM5 | L | 225 | 5x75 | G.S6 | S | 322 | G.S6.03 |
Van-der-waals | TM5 | L | 225 | 5x75 | G.S6 | S | 322 | G.S6.03 |
Polar | ICL3 | Q | 226 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | ICL3 | Q | 226 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | F | 355 | 6x25 | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | ICL3 | Q | 226 | - | G.S6 | S | 322 | G.S6.03 |
Hydrophobic | TM4 | P | 139 | 4x39 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM5 | L | 225 | 5x75 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM6 | T | 366 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM2 | N | 60 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | N | 60 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Ionic | C-term | R | 458 | - | G.H3 | E | 246 | G.H3.04 |
Polar | C-term | R | 458 | - | G.H3 | E | 246 | G.H3.04 |
Hydrophobic | C-term | R | 458 | - | G.H3 | E | 246 | G.H3.04 |
Van-der-waals | C-term | R | 458 | - | G.H3 | E | 246 | G.H3.04 |
Polar | C-term | C | 460 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | C | 460 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | ICL2 | L | 131 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | L | 131 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | TM4 | T | 138 | 4x38 | G.HN | Q | 28 | G.HN.52 |
Polar | ICL3 | Q | 348 | - | G.H4 | D | 310 | G.H4.17 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL2 | P | 130 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM5 | I | 211 | 5x61 | G.H5 | L | 354 | G.H5.25 |
Ionic | ICL3 | R | 352 | - | G.H4 | E | 309 | G.H4.16 |
Polar | ICL3 | R | 352 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | ICL3 | R | 352 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | ICL3 | R | 352 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | TM6 | K | 362 | 6x32 | G.H5 | L | 354 | G.H5.25 |