G12 - M4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 K 228 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM2 N 67 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 N 67 2x39 G.H5 I 378 G.H5.23
Hydrophobic ICL2 A 142 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 A 142 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM7 Y 453 7x53 G.H5 M 379 G.H5.24
Van-der-waals TM7 Y 453 7x53 G.H5 M 379 G.H5.24
Ionic ICL3 K 235 - G.H4 E 325 G.H4.05
Polar ICL3 K 235 - G.H4 E 325 G.H4.05
Hydrophobic ICL3 K 235 - G.H4 E 325 G.H4.05
Van-der-waals ICL3 K 235 - G.H4 E 325 G.H4.05
Ionic TM6 R 394 6x29 G.H5 D 368 G.H5.13
Polar TM6 R 394 6x29 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 394 6x29 G.H5 L 375 G.H5.20
Van-der-waals TM6 R 394 6x29 G.H5 L 375 G.H5.20
Polar H8 N 457 8x47 G.H5 K 376 G.H5.21
Hydrophobic TM2 L 71 2x43 G.H5 M 379 G.H5.24
Van-der-waals TM2 L 71 2x43 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 138 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 P 137 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM6 R 394 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 394 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM6 I 402 6x37 G.H5 L 380 G.H5.25
Hydrophobic TM2 N 68 2x40 G.H5 M 379 G.H5.24
Van-der-waals TM2 N 68 2x40 G.H5 M 379 G.H5.24
Hydrophobic TM3 V 134 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM5 R 225 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 225 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM5 I 218 5x61 G.H5 L 380 G.H5.25
Hydrophobic H8 N 457 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 457 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 F 460 8x50 G.H5 M 379 G.H5.24
Van-der-waals H8 F 460 8x50 G.H5 M 379 G.H5.24
Polar TM3 C 133 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 C 133 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 V 134 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 134 3x54 G.H5 L 375 G.H5.20
Polar TM6 Q 390 6x25 G.h4s6 R 342 G.h4s6.11
Hydrophobic TM7 A 454 7x54 G.H5 M 379 G.H5.24
Hydrophobic ICL2 A 142 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 A 142 34x55 G.hns1 R 55 G.hns1.02
Polar TM6 R 394 6x29 G.H5 L 371 G.H5.16
Hydrophobic TM6 R 394 6x29 G.H5 L 371 G.H5.16
Van-der-waals TM6 R 394 6x29 G.H5 L 371 G.H5.16
Hydrophobic TM3 V 134 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL3 K 387 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 K 387 - G.S6 F 347 G.S6.02
Hydrophobic ICL2 P 137 34x50 G.H5 K 367 G.H5.12
Polar TM3 R 130 3x50 G.H5 M 379 G.H5.24
Polar ICL2 P 137 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 137 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 137 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 137 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 137 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 138 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 138 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM3 R 130 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM3 C 133 3x53 G.H5 I 378 G.H5.23
Polar TM3 R 130 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 130 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 I 378 G.H5.23
Polar TM6 K 397 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 397 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 397 6x32 G.H5 Q 381 G.H5.26
Polar TM5 R 225 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM5 R 225 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 R 225 5x68 G.H5 K 367 G.H5.12
Ionic ICL3 R 386 - G.H4 D 336 G.H4.16
Hydrophobic ICL2 L 138 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 138 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM7 C 456 7x56 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 138 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 138 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 P 141 34x54 G.H5 N 374 G.H5.19
Hydrophobic TM6 V 398 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 V 398 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM6 T 401 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 V 398 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 V 398 6x33 G.H5 L 380 G.H5.25
Polar TM5 H 229 5x72 G.H5 H 364 G.H5.09
Aromatic TM5 H 229 5x72 G.H5 H 364 G.H5.09
Hydrophobic TM5 H 229 5x72 G.H5 H 364 G.H5.09
Van-der-waals TM5 H 229 5x72 G.H5 H 364 G.H5.09