G15 -
α1A-adrenoceptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 11.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | V | 379 | - | G.H3 | A | 256 | G.H3.07 |
Hydrophobic | C-term | I | 377 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | TM5 | A | 211 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | V | 379 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | C-term | V | 379 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | V | 379 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Van-der-waals | H8 | S | 330 | 8x47 | G.H5 | E | 370 | G.H5.22 |
Polar | C-term | S | 418 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Hydrophobic | TM5 | E | 214 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | E | 214 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | K | 269 | 6x32 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL3 | K | 223 | - | G.S6 | F | 340 | G.S6.02 |
Polar | TM5 | G | 221 | 5x75 | G.S6 | L | 339 | G.S6.01 |
Van-der-waals | TM5 | G | 221 | 5x75 | G.S6 | L | 339 | G.S6.01 |
Hydrophobic | C-term | G | 380 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Van-der-waals | C-term | G | 380 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Hydrophobic | TM3 | V | 128 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | I | 388 | - | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | C-term | I | 377 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | C-term | V | 375 | - | G.H3 | L | 264 | G.H3.15 |
Van-der-waals | C-term | V | 375 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | C-term | C | 395 | - | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | C-term | C | 395 | - | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | C-term | P | 378 | - | G.H2 | K | 213 | G.H2.01 |
Polar | ICL2 | R | 133 | 34x52 | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | TM5 | E | 214 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Aromatic | C-term | W | 397 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | W | 397 | - | G.H2 | H | 221 | G.H2.09 |
Ionic | TM6 | K | 269 | 6x32 | G.H5 | D | 369 | G.H5.21 |
Polar | TM6 | K | 269 | 6x32 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | C-term | S | 417 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Van-der-waals | C-term | S | 417 | - | H.hbhc | Y | 122 | H.hbhc.01 |
Hydrophobic | TM3 | V | 128 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL2 | R | 133 | 34x52 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | R | 133 | 34x52 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM6 | A | 270 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | A | 270 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | S | 381 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Van-der-waals | C-term | S | 381 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Ionic | C-term | E | 383 | - | G.H2 | K | 217 | G.H2.05 |
Polar | C-term | E | 383 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | E | 383 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | E | 383 | - | G.H2 | K | 217 | G.H2.05 |
Polar | TM7 | S | 329 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM7 | S | 329 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | S | 329 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | S | 329 | 7x56 | G.H5 | E | 370 | G.H5.22 |
Ionic | C-term | D | 373 | - | G.h3s5 | K | 268 | G.h3s5.01 |
Polar | C-term | D | 373 | - | G.h3s5 | K | 268 | G.h3s5.01 |
Van-der-waals | C-term | D | 373 | - | G.h3s5 | K | 268 | G.h3s5.01 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | C-term | I | 377 | - | G.H2 | W | 219 | G.H2.07 |
Ionic | C-term | R | 382 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Polar | C-term | R | 382 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Hydrophobic | TM5 | L | 218 | 5x72 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM5 | L | 218 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | L | 218 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | C-term | Q | 416 | - | H.hbhc | K | 123 | H.hbhc.02 |
Van-der-waals | C-term | Q | 416 | - | H.hbhc | K | 123 | H.hbhc.02 |
Hydrophobic | TM5 | E | 214 | 5x68 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | I | 452 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | C-term | W | 397 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | W | 397 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | C-term | V | 375 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Ionic | C-term | R | 382 | - | G.H3 | E | 253 | G.H3.04 |
Polar | C-term | R | 382 | - | G.H3 | E | 253 | G.H3.04 |
Van-der-waals | C-term | R | 382 | - | G.H3 | E | 253 | G.H3.04 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Polar | C-term | I | 377 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | I | 377 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | I | 377 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | C-term | D | 373 | - | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | C-term | D | 373 | - | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | C-term | V | 379 | - | G.H3 | L | 257 | G.H3.08 |
Ionic | C-term | K | 372 | - | G.H3 | E | 263 | G.H3.14 |
Polar | C-term | K | 372 | - | G.H3 | E | 263 | G.H3.14 |
Van-der-waals | C-term | K | 372 | - | G.H3 | E | 263 | G.H3.14 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM3 | V | 128 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | V | 128 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Polar | C-term | Y | 386 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | C-term | Y | 386 | - | G.H3 | T | 260 | G.H3.11 |
Van-der-waals | C-term | Y | 386 | - | G.H3 | T | 260 | G.H3.11 |
Polar | C-term | P | 450 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | C-term | P | 450 | - | G.h1ha | A | 68 | G.h1ha.02 |
Van-der-waals | C-term | P | 450 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | C-term | T | 384 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | TM3 | G | 127 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | R | 124 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 124 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Polar | TM5 | L | 222 | 5x76 | G.S6 | L | 339 | G.S6.01 |
Hydrophobic | TM5 | L | 222 | 5x76 | G.S6 | L | 339 | G.S6.01 |
Van-der-waals | TM5 | L | 222 | 5x76 | G.S6 | L | 339 | G.S6.01 |
Hydrophobic | C-term | V | 379 | - | G.H3 | E | 253 | G.H3.04 |
Van-der-waals | C-term | V | 379 | - | G.H3 | E | 253 | G.H3.04 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM5 | L | 222 | 5x76 | G.H4 | T | 317 | G.H4.16 |
Van-der-waals | TM5 | L | 222 | 5x76 | G.H4 | T | 317 | G.H4.16 |
Hydrophobic | C-term | I | 452 | - | G.h1ha | A | 68 | G.h1ha.02 |
Van-der-waals | C-term | I | 452 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | C-term | I | 377 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Van-der-waals | C-term | I | 377 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Polar | TM4 | Q | 140 | 4x39 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | TM4 | Q | 140 | 4x39 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM5 | V | 207 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM5 | V | 207 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | T | 273 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | T | 273 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Polar | TM3 | R | 124 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | R | 124 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | R | 124 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | T | 136 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | ICL2 | T | 136 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | C-term | I | 377 | - | G.H3 | L | 257 | G.H3.08 |
Van-der-waals | C-term | I | 377 | - | G.H3 | L | 257 | G.H3.08 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Polar | TM6 | K | 269 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | K | 269 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | K | 269 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | G | 380 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | G | 380 | - | G.H2 | K | 213 | G.H2.01 |
Aromatic | C-term | W | 397 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | C-term | W | 397 | - | G.H3 | W | 266 | G.H3.17 |
Ionic | TM5 | E | 214 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | TM6 | K | 269 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | K | 269 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | K | 269 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | R | 133 | 34x52 | G.s2s3 | K | 201 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 133 | 34x52 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | C-term | V | 375 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | V | 375 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | TM3 | V | 128 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Polar | ICL3 | K | 223 | - | G.S6 | L | 339 | G.S6.01 |
Hydrophobic | C-term | Y | 386 | - | G.H3 | E | 263 | G.H3.14 |
Hydrophobic | C-term | K | 390 | - | G.H3 | P | 265 | G.H3.16 |
Ionic | C-term | K | 453 | - | G.S1 | E | 42 | G.S1.01 |
Polar | C-term | K | 453 | - | G.S1 | E | 42 | G.S1.01 |
Van-der-waals | C-term | K | 453 | - | G.S1 | E | 42 | G.S1.01 |
Van-der-waals | C-term | V | 379 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Hydrophobic | TM6 | R | 266 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | R | 266 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Ionic | ICL3 | K | 223 | - | G.H5 | D | 361 | G.H5.13 |
Polar | ICL3 | K | 223 | - | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | ICL3 | K | 223 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | C-term | Y | 386 | - | G.H3 | L | 264 | G.H3.15 |
Van-der-waals | C-term | Y | 386 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | C-term | V | 375 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | V | 375 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | C-term | P | 450 | - | G.h1ha | G | 67 | G.h1ha.01 |
Van-der-waals | C-term | P | 450 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | C-term | I | 388 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | I | 388 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | TM7 | S | 329 | 7x56 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM6 | L | 274 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | R | 382 | - | G.H3 | A | 256 | G.H3.07 |
Van-der-waals | C-term | R | 382 | - | G.H3 | A | 256 | G.H3.07 |
Hydrophobic | C-term | F | 429 | - | G.HN | I | 31 | G.HN.46 |
Hydrophobic | C-term | I | 452 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | I | 452 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | TM5 | A | 211 | 5x65 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | C | 395 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | C-term | C | 395 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | C | 395 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | TM5 | V | 210 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | K | 453 | - | G.S2 | C | 196 | G.S2.05 |
Polar | TM3 | D | 123 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM6 | T | 273 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | T | 273 | 6x36 | G.H5 | N | 372 | G.H5.24 |