Gq - α2B-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 90.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 10.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 A 113 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 113 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 113 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 V 114 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 V 114 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL2 A 117 34x50 G.H5 L 349 G.H5.16
Polar TM6 R 368 6x32 G.H5 V 359 G.H5.26
Hydrophobic TM6 R 368 6x32 G.H5 V 359 G.H5.26
Van-der-waals TM6 R 368 6x32 G.H5 V 359 G.H5.26
Hydrophobic ICL2 L 118 34x51 G.S1 L 40 G.S1.02
Van-der-waals ICL2 L 118 34x51 G.S1 L 40 G.S1.02
Hydrophobic TM3 A 113 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 113 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM5 I 198 5x64 G.H5 L 349 G.H5.16
Polar H8 N 430 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 N 430 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 N 430 8x47 G.H5 N 357 G.H5.24
Hydrophobic ICL2 S 122 34x55 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 S 122 34x55 G.hns1 R 37 G.hns1.02
Polar TM2 Q 47 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM2 Q 47 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 Q 47 2x39 G.H5 E 355 G.H5.22
Hydrophobic ICL2 A 117 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 E 119 34x52 G.s2s3 S 198 G.s2s3.02
Hydrophobic TM6 F 369 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 F 369 6x33 G.H5 L 358 G.H5.25
Polar TM3 D 109 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 109 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM5 S 202 5x68 G.H5 L 349 G.H5.16
Hydrophobic TM5 I 195 5x61 G.H5 L 358 G.H5.25
Van-der-waals TM5 I 195 5x61 G.H5 L 358 G.H5.25
Van-der-waals TM4 T 125 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 R 365 6x29 G.H5 V 359 G.H5.26
Hydrophobic ICL2 L 118 34x51 G.H5 K 345 G.H5.12
Hydrophobic ICL2 L 118 34x51 G.H5 V 344 G.H5.11
Hydrophobic ICL2 L 118 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 118 34x51 G.H5 I 348 G.H5.15
Ionic TM6 R 365 6x29 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM3 V 114 3x54 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 118 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 L 118 34x51 G.H5 F 341 G.H5.08
Hydrophobic ICL2 S 122 34x55 G.hns1 R 38 G.hns1.03
Ionic ICL2 R 124 34x57 G.H5 E 355 G.H5.22
Polar ICL2 R 124 34x57 G.H5 E 355 G.H5.22
Van-der-waals ICL2 R 124 34x57 G.H5 E 355 G.H5.22
Hydrophobic TM5 P 207 5x73 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM3 R 110 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 110 3x50 G.H5 Y 356 G.H5.23
Polar H8 N 430 8x47 G.H5 E 355 G.H5.22
Polar ICL2 R 124 34x57 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 124 34x57 G.H5 Y 356 G.H5.23
Polar TM5 S 202 5x68 G.H5 Q 350 G.H5.17
Van-der-waals TM5 S 202 5x68 G.H5 Q 350 G.H5.17
Polar TM7 F 429 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM7 F 429 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 F 429 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM5 A 199 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM5 S 202 5x68 G.H5 L 353 G.H5.20
Hydrophobic TM3 V 114 3x54 G.H5 N 352 G.H5.19
Hydrophobic TM6 L 373 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM3 V 114 3x54 G.H5 L 353 G.H5.20