Gz - α2B-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 89.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 114 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM6 R 365 6x29 G.H5 C 355 G.H5.26
Hydrophobic TM5 I 195 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 I 195 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM5 I 198 5x64 G.H5 I 345 G.H5.16
Polar TM5 S 202 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 S 202 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM6 V 372 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 372 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM3 V 114 3x54 G.H5 N 348 G.H5.19
Polar H8 N 430 8x47 G.H5 Y 351 G.H5.22
Van-der-waals H8 N 430 8x47 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 A 117 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 A 117 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM7 F 429 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 F 429 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM2 A 45 2x37 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 A 117 34x50 G.H5 I 344 G.H5.15
Polar ICL3 G 212 - G.H4 R 306 G.H4.13
Hydrophobic TM5 S 202 5x68 G.H5 L 349 G.H5.20
Hydrophobic ICL2 S 122 34x55 G.hns1 R 32 G.hns1.03
Polar TM6 R 365 6x29 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 R 365 6x29 G.h4s6 E 316 G.h4s6.09
Polar TM3 A 113 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 113 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 113 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 L 118 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 118 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM5 A 199 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 118 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 118 34x51 G.H5 I 344 G.H5.15
Ionic TM6 R 365 6x29 G.h4s6 E 319 G.h4s6.12
Polar TM6 R 365 6x29 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 R 365 6x29 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 L 373 6x37 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 118 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 L 118 34x51 G.H5 T 341 G.H5.12
Hydrophobic ICL2 L 118 34x51 G.H5 V 340 G.H5.11
Polar TM2 N 48 2x40 G.H5 Y 351 G.H5.22
Hydrophobic TM2 N 48 2x40 G.H5 Y 351 G.H5.22
Van-der-waals TM2 N 48 2x40 G.H5 Y 351 G.H5.22
Hydrophobic TM6 A 361 6x25 G.h4s6 E 316 G.h4s6.09
Hydrophobic ICL3 G 214 - G.H4 R 306 G.H4.13
Van-der-waals ICL3 G 214 - G.H4 R 306 G.H4.13
Polar TM2 Q 47 2x39 G.H5 Y 351 G.H5.22
Hydrophobic TM2 Q 47 2x39 G.H5 Y 351 G.H5.22
Van-der-waals TM2 Q 47 2x39 G.H5 Y 351 G.H5.22
Hydrophobic TM5 G 206 5x72 G.h4s6 E 319 G.h4s6.12
Polar TM6 R 368 6x32 G.H5 G 353 G.H5.24
Hydrophobic TM6 F 369 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 F 369 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 118 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 L 118 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM4 T 125 4x38 G.HN Q 28 G.HN.52
Polar TM5 S 202 5x68 G.H5 Q 346 G.H5.17
Van-der-waals TM5 S 202 5x68 G.H5 Q 346 G.H5.17
Hydrophobic TM3 V 114 3x54 G.H5 I 352 G.H5.23
Hydrophobic ICL2 L 118 34x51 G.S1 I 34 G.S1.02
Hydrophobic TM3 R 110 3x50 G.H5 I 352 G.H5.23
Hydrophobic ICL3 G 211 - G.H4 V 302 G.H4.08
Polar TM6 R 368 6x32 G.H5 C 355 G.H5.26
Hydrophobic TM6 R 368 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 R 368 6x32 G.H5 C 355 G.H5.26
Ionic ICL3 R 358 - G.H4 E 309 G.H4.16
Polar ICL3 R 358 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 R 358 - G.H4 E 309 G.H4.16