Gz - α2C-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 R 248 - G.h4s6 K 318 G.h4s6.11
Polar TM5 R 240 5x68 G.S6 Y 321 G.S6.02
Van-der-waals TM5 R 240 5x68 G.S6 Y 321 G.S6.02
Hydrophobic ICL2 V 157 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 V 157 34x51 G.H5 T 341 G.H5.12
Hydrophobic ICL2 A 156 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 A 156 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM7 F 440 7x56 G.H5 G 353 G.H5.24
Ionic TM5 R 240 5x68 G.H5 D 342 G.H5.13
Polar TM5 R 240 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 R 240 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 240 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM2 A 84 2x37 G.H5 Y 351 G.H5.22
Polar TM2 N 87 2x40 G.H5 Y 351 G.H5.22
Hydrophobic TM2 N 87 2x40 G.H5 Y 351 G.H5.22
Van-der-waals TM2 N 87 2x40 G.H5 Y 351 G.H5.22
Hydrophobic TM5 L 244 5x72 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 L 244 5x72 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 L 384 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM5 I 233 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 I 233 5x61 G.H5 L 354 G.H5.25
Hydrophobic ICL3 P 250 - G.H4 R 306 G.H4.13
Van-der-waals C-term Q 462 - G.H3 N 258 G.H3.16
Hydrophobic TM3 V 153 3x54 G.H5 I 352 G.H5.23
Ionic ICL3 R 369 - G.H4 D 310 G.H4.17
Hydrophobic TM3 R 149 3x50 G.H5 I 352 G.H5.23
Ionic TM5 R 240 5x68 G.h4s6 E 319 G.h4s6.12
Polar TM5 R 240 5x68 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 R 240 5x68 G.h4s6 E 319 G.h4s6.12
Polar ICL2 L 161 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 161 34x55 G.hns1 R 32 G.hns1.03
Polar TM2 Q 86 2x39 G.H5 Y 351 G.H5.22
Hydrophobic TM2 Q 86 2x39 G.H5 Y 351 G.H5.22
Van-der-waals TM2 Q 86 2x39 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 V 157 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 V 157 34x51 G.S3 L 195 G.S3.01
Polar ICL3 R 248 - G.h4s6 K 315 G.h4s6.08
Van-der-waals ICL3 R 248 - G.h4s6 K 315 G.h4s6.08
Hydrophobic ICL2 V 157 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM3 V 153 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM6 V 383 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 383 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM5 A 237 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 N 160 34x54 G.H5 I 344 G.H5.15
Van-der-waals ICL2 N 160 34x54 G.H5 I 344 G.H5.15
Hydrophobic ICL2 L 161 34x55 G.S3 L 195 G.S3.01
Polar TM3 S 152 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 S 152 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 S 152 3x53 G.H5 N 348 G.H5.19
Polar TM6 R 376 6x29 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 R 376 6x29 G.h4s6 E 316 G.h4s6.09
Polar H8 N 441 8x47 G.H5 Y 351 G.H5.22
Van-der-waals H8 N 441 8x47 G.H5 Y 351 G.H5.22
Hydrophobic TM3 V 153 3x54 G.H5 N 348 G.H5.19
Hydrophobic TM6 F 380 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 V 372 6x25 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 V 372 6x25 G.h4s6 E 316 G.h4s6.09
Hydrophobic TM6 R 376 6x29 G.H5 C 355 G.H5.26
Hydrophobic ICL2 A 156 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 A 156 34x50 G.H5 I 345 G.H5.16
Hydrophobic C-term Q 462 - G.H3 W 259 G.H3.17
Polar TM5 R 240 5x68 G.H5 Q 346 G.H5.17
Hydrophobic TM5 R 240 5x68 G.H5 Q 346 G.H5.17
Van-der-waals TM5 R 240 5x68 G.H5 Q 346 G.H5.17
Polar TM6 R 379 6x32 G.H5 C 355 G.H5.26
Hydrophobic TM6 R 379 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 R 379 6x32 G.H5 C 355 G.H5.26
Polar ICL2 R 163 34x57 G.H5 N 348 G.H5.19
Van-der-waals ICL2 R 163 34x57 G.H5 N 348 G.H5.19
Polar TM6 R 379 6x32 G.H5 G 353 G.H5.24
Van-der-waals TM6 R 379 6x32 G.H5 G 353 G.H5.24