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β2-adrenoceptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | R | 131 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 131 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | F | 139 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | H | 390 | - | H.hbhc | M | 114 | H.hbhc.02 |
Van-der-waals | C-term | H | 390 | - | H.hbhc | M | 114 | H.hbhc.02 |
Hydrophobic | ICL3 | F | 240 | - | G.S6 | M | 323 | G.S6.05 |
Hydrophobic | TM5 | I | 233 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | I | 233 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | L | 381 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | L | 381 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Polar | TM3 | A | 134 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 134 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 134 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM6 | I | 278 | 6x40 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | H | 390 | - | H.hbhc | T | 117 | H.hbhc.05 |
Van-der-waals | C-term | H | 390 | - | H.hbhc | T | 117 | H.hbhc.05 |
Hydrophobic | TM3 | I | 135 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 135 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | V | 394 | - | H.HA | V | 72 | H.HA.10 |
Hydrophobic | TM3 | I | 135 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Aromatic | C-term | F | 387 | - | H.HA | R | 86 | H.HA.24 |
Hydrophobic | C-term | F | 387 | - | H.HA | R | 86 | H.HA.24 |
Van-der-waals | C-term | F | 387 | - | H.HA | R | 86 | H.HA.24 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | TM3 | I | 135 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | D | 397 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | D | 397 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | C-term | V | 394 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | V | 394 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | ICL2 | P | 138 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 138 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL3 | F | 240 | - | G.H4 | Q | 305 | G.H4.12 |
Van-der-waals | ICL3 | F | 240 | - | G.H4 | Q | 305 | G.H4.12 |
Polar | TM6 | K | 267 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 267 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | L | 275 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 275 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | Q | 391 | - | H.hbhc | T | 117 | H.hbhc.05 |
Polar | C-term | P | 395 | - | H.HA | Q | 68 | H.HA.06 |
Ionic | ICL3 | R | 260 | - | G.H4 | E | 309 | G.H4.16 |
Polar | ICL3 | R | 260 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | ICL3 | R | 260 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | F | 139 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL2 | Q | 142 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 142 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Ionic | TM6 | K | 267 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 267 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 267 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | F | 139 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Ionic | TM5 | K | 232 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | K | 232 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | K | 232 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | K | 232 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | G | 392 | - | H.hbhc | T | 117 | H.hbhc.05 |
Van-der-waals | C-term | G | 392 | - | H.hbhc | T | 117 | H.hbhc.05 |
Hydrophobic | ICL2 | P | 138 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | TM6 | T | 274 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | T | 274 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | T | 274 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM5 | Q | 229 | 5x68 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | Q | 229 | 5x68 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | A | 226 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | T | 274 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Polar | TM5 | Q | 229 | 5x68 | G.H5 | A | 345 | G.H5.17 |
Hydrophobic | TM5 | Q | 229 | 5x68 | G.H5 | A | 345 | G.H5.17 |
Van-der-waals | TM5 | Q | 229 | 5x68 | G.H5 | A | 345 | G.H5.17 |
Hydrophobic | C-term | F | 387 | - | H.HB | V | 111 | H.HB.13 |
Hydrophobic | C-term | Y | 350 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | E | 379 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | E | 379 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | V | 388 | - | H.hbhc | M | 114 | H.hbhc.02 |
Van-der-waals | C-term | V | 388 | - | H.hbhc | M | 114 | H.hbhc.02 |
Hydrophobic | C-term | F | 387 | - | H.HB | S | 112 | H.HB.14 |
Hydrophobic | C-term | L | 376 | - | G.H3 | M | 249 | G.H3.07 |
Hydrophobic | C-term | E | 379 | - | G.s4h3 | L | 235 | G.s4h3.08 |
Van-der-waals | C-term | E | 379 | - | G.s4h3 | L | 235 | G.s4h3.08 |
Hydrophobic | C-term | G | 389 | - | H.hbhc | M | 114 | H.hbhc.02 |
Van-der-waals | C-term | G | 389 | - | H.hbhc | M | 114 | H.hbhc.02 |
Polar | TM5 | Q | 229 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | Q | 229 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | ICL2 | S | 143 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | S | 143 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | TM6 | A | 271 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | Q | 229 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | Q | 229 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL3 | F | 240 | - | G.H4 | A | 302 | G.H4.08 |
Van-der-waals | ICL3 | F | 240 | - | G.H4 | A | 302 | G.H4.08 |
Hydrophobic | TM5 | L | 230 | 5x69 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM5 | V | 222 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | V | 222 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL3 | Q | 243 | - | G.H4 | D | 299 | G.H4.05 |
Van-der-waals | ICL3 | Q | 243 | - | G.H4 | D | 299 | G.H4.05 |