Gs - β3-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 143 34x51 G.S3 F 219 G.S3.03
Ionic TM5 E 241 5x75 G.H5 R 385 G.H5.17
Polar TM5 E 241 5x75 G.H5 R 385 G.H5.17
Hydrophobic TM5 E 241 5x75 G.H5 R 385 G.H5.17
Van-der-waals TM5 E 241 5x75 G.H5 R 385 G.H5.17
Polar TM3 A 138 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 138 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 138 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 238 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 L 238 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM2 M 71 2x38 G.hns1 R 38 G.hns1.02
Van-der-waals TM2 M 71 2x38 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 A 231 5x65 G.H5 L 393 G.H5.25
Hydrophobic ICL3 R 244 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 R 244 - G.H4 L 346 G.H4.16
Hydrophobic ICL3 F 245 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 F 245 - G.H4 D 343 G.H4.13
Hydrophobic ICL2 L 143 34x51 G.S3 V 217 G.S3.01
Polar ICL2 R 144 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 R 144 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 144 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 L 143 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 143 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL3 F 245 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 F 245 - G.H4 L 346 G.H4.16
Hydrophobic TM3 A 138 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 138 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 142 34x50 G.H5 H 387 G.H5.19
Aromatic ICL2 Y 145 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 145 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 V 227 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 V 227 5x61 G.H5 L 393 G.H5.25
Ionic TM6 R 289 6x32 G.H5 E 392 G.H5.24
Polar TM6 R 289 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 289 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 289 6x32 G.H5 E 392 G.H5.24
Aromatic TM3 R 135 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 135 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 142 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM6 R 289 6x32 G.H5 L 393 G.H5.25
Hydrophobic TM3 V 139 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 143 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 143 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM5 Q 234 5x68 G.H5 L 394 G.H5.26
Ionic ICL3 R 244 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 R 244 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 R 244 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 R 244 - G.hgh4 D 323 G.hgh4.13
Aromatic ICL3 F 245 - G.H4 R 347 G.H4.17
Hydrophobic ICL3 F 245 - G.H4 R 347 G.H4.17
Hydrophobic TM6 L 294 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 294 6x37 G.H5 L 393 G.H5.25
Polar TM5 Q 234 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 234 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 234 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 143 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 A 231 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL3 F 245 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 F 245 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 V 230 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 230 5x64 G.H5 Q 384 G.H5.16
Polar ICL2 L 143 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 143 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 143 34x51 G.S1 H 41 G.S1.02
Polar TM6 A 290 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 290 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 290 6x33 G.H5 L 393 G.H5.25
Polar TM6 T 293 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 293 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 293 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 R 144 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM5 L 238 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 234 5x68 G.H5 L 388 G.H5.20
Polar TM3 V 139 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 139 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 139 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM7 R 348 7x55 G.H5 E 392 G.H5.24
Van-der-waals TM7 R 348 7x55 G.H5 E 392 G.H5.24
Hydrophobic ICL2 A 147 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 P 142 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 142 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 143 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM6 T 293 6x36 G.H5 L 393 G.H5.25
Polar TM5 Q 234 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 234 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 234 5x68 G.H5 R 385 G.H5.17
Polar TM6 R 289 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 289 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 289 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 238 5x72 G.H5 L 394 G.H5.26
Polar TM5 Q 234 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 Q 234 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 Q 234 5x68 G.H5 D 381 G.H5.13
Hydrophobic ICL3 R 244 - G.H4 R 342 G.H4.12
Ionic H8 R 353 8x51 G.H5 E 392 G.H5.24
Polar H8 R 353 8x51 G.H5 E 392 G.H5.24
Van-der-waals H8 R 353 8x51 G.H5 E 392 G.H5.24
Polar H8 S 349 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 V 139 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 142 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 142 34x50 G.H5 R 380 G.H5.12
Polar TM4 T 150 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM3 V 139 3x54 G.H5 H 387 G.H5.19
Polar TM2 T 72 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 T 72 2x39 G.H5 Y 391 G.H5.23