Gq - B1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 88.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 10.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 V 71 2x38 G.H5 E 355 G.H5.22
Van-der-waals TM2 V 71 2x38 G.H5 E 355 G.H5.22
Polar TM3 V 138 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 V 138 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 V 138 3x53 G.H5 N 352 G.H5.19
Polar ICL3 G 242 - G.h4s6 S 320 G.h4s6.11
Van-der-waals ICL3 G 242 - G.h4s6 S 320 G.h4s6.11
Hydrophobic TM3 V 138 3x53 G.H5 Y 356 G.H5.23
Hydrophobic C-term F 350 - G.H2 R 213 G.H2.04
Van-der-waals C-term F 350 - G.H2 R 213 G.H2.04
Hydrophobic C-term W 351 - G.H2 I 217 G.H2.08
Hydrophobic TM5 V 235 5x71 G.H5 A 342 G.H5.09
Aromatic C-term F 350 - G.h2s4 F 220 G.h2s4.01
Hydrophobic C-term F 350 - G.h2s4 F 220 G.h2s4.01
Van-der-waals C-term F 350 - G.h2s4 F 220 G.h2s4.01
Hydrophobic TM2 A 72 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 A 72 2x39 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 R 147 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 R 147 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic C-term I 346 - G.H3 P 262 G.H3.16
Van-der-waals C-term I 346 - G.H3 P 262 G.H3.16
Hydrophobic H8 L 318 8x49 G.H5 K 354 G.H5.21
Hydrophobic TM3 L 139 3x54 G.H5 L 358 G.H5.25
Hydrophobic ICL3 G 242 - G.h4s6 I 323 G.h4s6.20
Polar TM7 Y 312 7x53 G.H5 N 357 G.H5.24
Hydrophobic TM7 Y 312 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 Y 312 7x53 G.H5 N 357 G.H5.24
Polar TM5 T 238 5x74 G.S6 S 326 G.S6.03
Hydrophobic ICL3 G 241 - G.h4s6 I 323 G.h4s6.20
Hydrophobic TM6 L 251 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 251 6x36 G.H5 L 358 G.H5.25
Hydrophobic H8 L 318 8x49 G.H5 E 355 G.H5.22
Hydrophobic TM3 L 139 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 L 139 3x54 G.H5 L 349 G.H5.16
Polar TM7 V 313 7x54 G.H5 N 357 G.H5.24
Hydrophobic TM7 V 313 7x54 G.H5 N 357 G.H5.24
Hydrophobic TM3 L 139 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 L 139 3x54 G.H5 L 353 G.H5.20
Polar H8 R 317 8x48 G.H5 V 359 G.H5.26
Hydrophobic H8 R 317 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 R 317 8x48 G.H5 V 359 G.H5.26
Hydrophobic ICL2 M 143 34x51 G.S3 V 199 G.S3.01
Ionic TM4 R 150 4x38 G.H5 E 355 G.H5.22
Polar TM3 R 135 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 135 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 135 3x50 G.H5 Y 356 G.H5.23
Hydrophobic C-term F 347 - G.H2 I 217 G.H2.08
Van-der-waals C-term F 347 - G.H2 I 217 G.H2.08
Hydrophobic ICL2 M 143 34x51 G.S1 L 40 G.S1.02
Hydrophobic TM2 N 70 2x37 G.H5 E 355 G.H5.22
Polar TM2 A 72 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM2 A 72 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 A 72 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM5 L 229 5x65 G.H5 L 349 G.H5.16
Hydrophobic ICL2 M 143 34x51 G.H5 V 344 G.H5.11
Hydrophobic C-term F 350 - G.H2 W 216 G.H2.07
Hydrophobic TM6 K 247 6x32 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 247 6x32 G.H5 V 359 G.H5.26
Polar ICL2 R 147 34x55 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 R 147 34x55 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 R 147 34x55 G.s2s3 S 198 G.s2s3.02
Polar H8 G 316 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 G 316 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 G 316 8x47 G.H5 N 357 G.H5.24
Hydrophobic ICL2 P 142 34x50 G.H5 K 345 G.H5.12
Hydrophobic C-term F 350 - G.H2 I 217 G.H2.08
Van-der-waals C-term F 350 - G.H2 I 217 G.H2.08
Hydrophobic C-term F 350 - G.H3 W 263 G.H3.17
Van-der-waals C-term F 350 - G.H3 W 263 G.H3.17
Polar TM4 R 150 4x38 G.H5 Y 356 G.H5.23
Van-der-waals TM4 R 150 4x38 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 R 146 34x54 G.H5 I 348 G.H5.15
Van-der-waals ICL2 R 146 34x54 G.H5 I 348 G.H5.15
Hydrophobic ICL2 M 143 34x51 G.H5 K 345 G.H5.12
Van-der-waals ICL2 M 143 34x51 G.H5 K 345 G.H5.12
Hydrophobic ICL2 P 142 34x50 G.H5 I 348 G.H5.15
Hydrophobic C-term F 347 - G.H3 W 263 G.H3.17
Hydrophobic TM6 I 252 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM4 Q 149 4x37 G.HN R 34 G.HN.52
Van-der-waals TM4 Q 149 4x37 G.HN R 34 G.HN.52
Polar TM3 D 134 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 134 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 134 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM5 T 238 5x74 G.H5 F 339 G.H5.06
Polar TM6 T 248 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 T 248 6x33 G.H5 L 358 G.H5.25
Hydrophobic ICL3 R 243 - G.H5 V 359 G.H5.26
Van-der-waals ICL3 R 243 - G.H5 V 359 G.H5.26
Hydrophobic C-term F 350 - G.H2 R 214 G.H2.05
Hydrophobic TM3 R 135 3x50 G.H5 L 358 G.H5.25
Hydrophobic ICL3 C 240 - G.H4 V 314 G.H4.16
Van-der-waals ICL3 C 240 - G.H4 V 314 G.H4.16
Hydrophobic C-term I 346 - G.H3 W 263 G.H3.17
Van-der-waals C-term I 346 - G.H3 W 263 G.H3.17
Hydrophobic ICL2 M 143 34x51 G.H5 F 341 G.H5.08
Aromatic C-term F 350 - G.H3 Y 261 G.H3.15
Hydrophobic C-term F 350 - G.H3 Y 261 G.H3.15
Van-der-waals C-term F 350 - G.H3 Y 261 G.H3.15
Hydrophobic TM5 R 232 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 R 232 5x68 G.H5 L 349 G.H5.16
Hydrophobic ICL2 R 146 34x54 G.S1 L 40 G.S1.02
Van-der-waals ICL2 R 146 34x54 G.S1 L 40 G.S1.02
Hydrophobic TM3 L 139 3x54 G.H5 N 352 G.H5.19
Polar TM5 R 232 5x68 G.H5 K 345 G.H5.12
Hydrophobic TM5 R 232 5x68 G.H5 K 345 G.H5.12
Van-der-waals TM5 R 232 5x68 G.H5 K 345 G.H5.12
Ionic H8 R 317 8x48 G.h4s6 D 321 G.h4s6.12
Polar H8 R 317 8x48 G.h4s6 D 321 G.h4s6.12
Hydrophobic H8 R 317 8x48 G.h4s6 D 321 G.h4s6.12
Van-der-waals H8 R 317 8x48 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM5 R 239 5x75 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM5 R 239 5x75 G.h4s6 I 323 G.h4s6.20
Polar ICL3 D 245 - G.H5 Q 350 G.H5.17
Polar ICL2 R 146 34x54 G.h2s4 T 224 G.h2s4.05
Hydrophobic TM6 T 248 6x33 G.H5 L 353 G.H5.20
Van-der-waals TM6 T 248 6x33 G.H5 L 353 G.H5.20
Hydrophobic TM5 R 239 5x75 G.S6 Y 325 G.S6.02
Hydrophobic ICL2 M 143 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 M 143 34x51 G.H5 I 348 G.H5.15
Polar ICL3 C 240 - G.S6 I 324 G.S6.01
Hydrophobic ICL3 C 240 - G.S6 I 324 G.S6.01
Van-der-waals ICL3 C 240 - G.S6 I 324 G.S6.01
Ionic TM5 R 232 5x68 G.H5 D 346 G.H5.13
Polar H8 F 319 8x50 G.H5 N 357 G.H5.24
Hydrophobic H8 F 319 8x50 G.H5 N 357 G.H5.24