Gi1 -
B2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 86.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 10.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | E | 265 | 6x30 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | M | 163 | 34x51 | G.H5 | V | 339 | G.H5.11 |
Van-der-waals | ICL2 | M | 163 | 34x51 | G.H5 | V | 339 | G.H5.11 |
Hydrophobic | C-term | L | 370 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Van-der-waals | C-term | L | 370 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | ICL3 | F | 259 | - | G.S6 | T | 321 | G.S6.03 |
Van-der-waals | ICL3 | F | 259 | - | G.S6 | T | 321 | G.S6.03 |
Hydrophobic | C-term | I | 374 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | I | 374 | - | G.H2 | R | 208 | G.H2.04 |
Polar | TM3 | A | 158 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 158 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 158 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Ionic | ICL2 | R | 169 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Polar | TM6 | R | 267 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 267 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 267 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | L | 251 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | A | 158 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Polar | H8 | R | 338 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | H8 | R | 338 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | H8 | R | 338 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Ionic | C-term | R | 378 | - | G.s4h3 | D | 237 | G.s4h3.11 |
Polar | C-term | R | 378 | - | G.s4h3 | D | 237 | G.s4h3.11 |
Van-der-waals | C-term | R | 378 | - | G.s4h3 | D | 237 | G.s4h3.11 |
Hydrophobic | TM5 | L | 251 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | L | 159 | 3x54 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | T | 162 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | T | 162 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | R | 371 | - | G.H2 | I | 212 | G.H2.08 |
Polar | ICL3 | E | 261 | - | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | ICL3 | E | 261 | - | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | ICL2 | T | 162 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | T | 162 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | M | 163 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | M | 163 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL3 | E | 261 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | ICL3 | E | 261 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | ICL3 | F | 259 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM6 | I | 262 | 6x27 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | ICL2 | M | 168 | 34x56 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL3 | F | 259 | - | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | ICL3 | F | 259 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | TM6 | V | 272 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | L | 370 | - | G.H3 | N | 256 | G.H3.15 |
Van-der-waals | C-term | L | 370 | - | G.H3 | N | 256 | G.H3.15 |
Hydrophobic | ICL2 | M | 163 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | M | 163 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Polar | TM6 | A | 268 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 268 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Ionic | C-term | E | 364 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | E | 364 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | C-term | E | 364 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | E | 364 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | C-term | L | 370 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | ICL2 | M | 163 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | TM3 | L | 159 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM2 | A | 92 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | R | 167 | 34x55 | G.S1 | V | 34 | G.S1.02 |
Van-der-waals | ICL2 | R | 167 | 34x55 | G.S1 | V | 34 | G.S1.02 |
Ionic | ICL3 | K | 260 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | K | 260 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | K | 260 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | K | 260 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | I | 374 | - | G.H3 | L | 249 | G.H3.08 |
Ionic | C-term | E | 377 | - | G.H3 | K | 248 | G.H3.07 |
Polar | C-term | E | 377 | - | G.H3 | K | 248 | G.H3.07 |
Hydrophobic | C-term | E | 377 | - | G.H3 | K | 248 | G.H3.07 |
Van-der-waals | C-term | E | 377 | - | G.H3 | K | 248 | G.H3.07 |
Hydrophobic | ICL2 | M | 163 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | M | 163 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM5 | V | 250 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | R | 155 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Ionic | H8 | R | 338 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Polar | H8 | R | 338 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | H8 | R | 338 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | R | 338 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM5 | M | 256 | 5x70 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | M | 256 | 5x70 | G.H5 | D | 337 | G.H5.09 |
Polar | ICL2 | R | 167 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL2 | R | 167 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | R | 167 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | R | 167 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Polar | TM2 | T | 90 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | T | 90 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | T | 90 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Polar | ICL2 | R | 169 | 34x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | M | 256 | 5x70 | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | TM5 | M | 256 | 5x70 | G.S6 | Y | 320 | G.S6.02 |
Polar | TM5 | N | 254 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | N | 254 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | N | 254 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM3 | L | 159 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | L | 159 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | T | 264 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | T | 264 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | M | 256 | 5x70 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | M | 256 | 5x70 | G.H5 | D | 341 | G.H5.13 |
Polar | H8 | K | 337 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | H8 | K | 337 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | H8 | K | 337 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Polar | ICL2 | R | 167 | 34x55 | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | ICL2 | R | 167 | 34x55 | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL2 | R | 167 | 34x55 | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | TM6 | A | 268 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | A | 268 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Polar | H8 | G | 336 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | G | 336 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | G | 336 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM3 | L | 159 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | K | 260 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | K | 260 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM3 | R | 155 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 155 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 155 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | A | 92 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | A | 92 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM6 | L | 271 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | R | 167 | 34x55 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | R | 167 | 34x55 | G.S3 | L | 194 | G.S3.01 |