Gq - C5a2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM4 R 173 4x65 G.H5 V 359 G.H5.26
Van-der-waals TM4 R 173 4x65 G.H5 V 359 G.H5.26
Polar N-term V 6 - G.S6 I 324 G.S6.01
Van-der-waals N-term V 6 - G.S6 I 324 G.S6.01
Polar N-term N 3 - G.h4s6 N 317 G.h4s6.08
Hydrophobic N-term N 3 - G.h4s6 N 317 G.h4s6.08
Van-der-waals N-term N 3 - G.h4s6 N 317 G.h4s6.08
Hydrophobic N-term Y 13 - G.H5 E 335 G.H5.02
Polar ECL2 H 179 - G.s2s3 S 198 G.s2s3.02
Hydrophobic ECL2 H 179 - G.s2s3 S 198 G.s2s3.02
Van-der-waals ECL2 H 179 - G.s2s3 S 198 G.s2s3.02
Hydrophobic TM7 L 266 7x27 G.H5 K 354 G.H5.21
Van-der-waals TM7 L 266 7x27 G.H5 K 354 G.H5.21
Hydrophobic TM6 L 252 6x54 G.H5 L 358 G.H5.25
Polar ECL2 H 176 - G.s2s3 S 198 G.s2s3.02
Hydrophobic ECL2 H 176 - G.s2s3 S 198 G.s2s3.02
Van-der-waals ECL2 H 176 - G.s2s3 S 198 G.s2s3.02
Hydrophobic TM7 L 266 7x27 G.H5 L 351 G.H5.18
Van-der-waals TM7 L 266 7x27 G.H5 L 351 G.H5.18
Hydrophobic N-term L 24 - G.H5 F 339 G.H5.06
Van-der-waals N-term L 24 - G.H5 F 339 G.H5.06
Hydrophobic ECL2 V 187 45x51 G.H5 Y 356 G.H5.23
Van-der-waals ECL2 V 187 45x51 G.H5 Y 356 G.H5.23
Hydrophobic N-term L 16 - G.H5 F 339 G.H5.06
Hydrophobic ECL2 E 178 - G.H5 L 349 G.H5.16
Polar ECL2 E 178 - G.s2s3 S 198 G.s2s3.02
Hydrophobic ECL2 E 178 - G.s2s3 S 198 G.s2s3.02
Van-der-waals ECL2 E 178 - G.s2s3 S 198 G.s2s3.02
Polar TM7 E 273 7x34 G.H5 N 357 G.H5.24
Hydrophobic TM7 E 273 7x34 G.H5 N 357 G.H5.24
Van-der-waals TM7 E 273 7x34 G.H5 N 357 G.H5.24
Polar N-term V 6 - G.S6 S 326 G.S6.03
Van-der-waals N-term V 6 - G.S6 S 326 G.S6.03
Ionic N-term E 9 - G.H4 R 306 G.H4.08
Polar N-term E 9 - G.H4 R 306 G.H4.08
Hydrophobic N-term E 9 - G.H4 R 306 G.H4.08
Van-der-waals N-term E 9 - G.H4 R 306 G.H4.08
Hydrophobic TM6 L 256 6x58 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 256 6x58 G.H5 L 358 G.H5.25
Ionic TM5 E 197 5x36 G.H5 K 354 G.H5.21
Van-der-waals N-term Y 10 - G.H5 A 343 G.H5.10
Polar ECL2 Y 190 - G.H5 E 355 G.H5.22
Van-der-waals ECL2 Y 190 - G.H5 E 355 G.H5.22
Polar N-term Y 10 - G.H5 V 340 G.H5.07
Hydrophobic N-term Y 10 - G.H5 V 340 G.H5.07
Van-der-waals N-term Y 10 - G.H5 V 340 G.H5.07
Ionic ECL2 E 178 - G.H5 K 345 G.H5.12
Polar ECL2 E 178 - G.H5 K 345 G.H5.12
Hydrophobic ECL2 E 178 - G.H5 K 345 G.H5.12
Van-der-waals ECL2 E 178 - G.H5 K 345 G.H5.12
Polar ECL2 F 180 - G.H5 K 345 G.H5.12
Hydrophobic ECL2 F 180 - G.H5 K 345 G.H5.12
Van-der-waals ECL2 F 180 - G.H5 K 345 G.H5.12
Polar ECL2 Q 185 - G.H5 Y 356 G.H5.23
Hydrophobic ECL2 Q 185 - G.H5 Y 356 G.H5.23
Van-der-waals ECL2 Q 185 - G.H5 Y 356 G.H5.23
Polar N-term N 3 - G.H4 V 314 G.H4.16
Hydrophobic N-term N 3 - G.H4 V 314 G.H4.16
Van-der-waals N-term N 3 - G.H4 V 314 G.H4.16
Hydrophobic N-term V 21 - G.H5 F 339 G.H5.06
Van-der-waals N-term V 21 - G.H5 F 339 G.H5.06
Hydrophobic ECL2 C 186 45x50 G.H5 Y 356 G.H5.23
Polar TM7 A 264 7x25 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM7 A 264 7x25 G.h4s6 D 321 G.h4s6.12
Van-der-waals TM7 A 264 7x25 G.h4s6 D 321 G.h4s6.12
Polar TM4 R 173 4x65 G.H5 L 358 G.H5.25
Van-der-waals TM4 R 173 4x65 G.H5 L 358 G.H5.25
Hydrophobic ECL3 A 260 - G.H5 K 354 G.H5.21
Aromatic ECL2 F 180 - G.H1 H 63 G.H1.12
Hydrophobic ECL2 F 180 - G.H1 H 63 G.H1.12
Van-der-waals ECL2 F 180 - G.H1 H 63 G.H1.12
Polar ECL2 G 192 - G.hns1 R 37 G.hns1.02
Hydrophobic ECL2 G 192 - G.hns1 R 37 G.hns1.02
Van-der-waals ECL2 G 192 - G.hns1 R 37 G.hns1.02
Hydrophobic ECL2 H 179 - G.H5 K 345 G.H5.12
Hydrophobic ECL2 V 187 45x51 G.H5 L 353 G.H5.20
Polar ECL2 G 191 - G.hns1 R 37 G.hns1.02
Hydrophobic ECL2 G 191 - G.hns1 R 37 G.hns1.02
Van-der-waals ECL2 G 191 - G.hns1 R 37 G.hns1.02
Hydrophobic TM7 L 270 7x31 G.H5 Q 350 G.H5.17
Van-der-waals TM7 L 270 7x31 G.H5 Q 350 G.H5.17
Aromatic N-term Y 8 - G.S6 H 327 G.S6.04
Hydrophobic N-term Y 8 - G.S6 H 327 G.S6.04
Van-der-waals N-term Y 8 - G.S6 H 327 G.S6.04
Polar ECL2 Q 177 - G.s2s3 Q 197 G.s2s3.01
Hydrophobic ECL2 Q 177 - G.s2s3 Q 197 G.s2s3.01
Van-der-waals ECL2 Q 177 - G.s2s3 Q 197 G.s2s3.01
Polar ECL2 V 188 45x52 G.H5 E 355 G.H5.22
Hydrophobic ECL2 V 188 45x52 G.H5 E 355 G.H5.22
Van-der-waals ECL2 V 188 45x52 G.H5 E 355 G.H5.22
Hydrophobic ECL2 F 180 - G.H5 A 342 G.H5.09
Polar ECL2 G 191 - G.H5 E 355 G.H5.22
Hydrophobic ECL3 N 262 - G.h3s5 S 267 G.h3s5.03
Van-der-waals ECL3 N 262 - G.h3s5 S 267 G.h3s5.03
Hydrophobic TM5 S 193 5x32 G.hns1 R 37 G.hns1.02
Van-der-waals TM5 S 193 5x32 G.hns1 R 37 G.hns1.02
Polar N-term D 22 - G.H5 A 343 G.H5.10
Hydrophobic N-term D 22 - G.H5 A 343 G.H5.10
Van-der-waals N-term D 22 - G.H5 A 343 G.H5.10
Polar ECL2 V 188 45x52 G.H5 Y 356 G.H5.23
Hydrophobic ECL2 H 176 - G.H5 L 353 G.H5.20
Hydrophobic N-term E 9 - G.S6 F 328 G.S6.05
Hydrophobic TM7 A 264 7x25 G.h4s6 I 323 G.h4s6.20
Polar N-term E 9 - G.H4 Q 303 G.H4.05
Van-der-waals N-term E 9 - G.H4 Q 303 G.H4.05
Hydrophobic ECL2 F 180 - G.H1 I 62 G.H1.11
Polar N-term Y 13 - G.H5 N 336 G.H5.03
Hydrophobic N-term Y 13 - G.H5 N 336 G.H5.03
Van-der-waals N-term Y 13 - G.H5 N 336 G.H5.03
Hydrophobic TM7 V 277 7x38 G.H5 V 359 G.H5.26
Polar ECL3 N 262 - G.H5 L 351 G.H5.18
Hydrophobic ECL3 N 262 - G.H5 L 351 G.H5.18
Van-der-waals ECL3 N 262 - G.H5 L 351 G.H5.18
Polar TM7 E 273 7x34 G.H5 L 358 G.H5.25
Hydrophobic TM7 E 273 7x34 G.H5 L 358 G.H5.25
Van-der-waals TM7 E 273 7x34 G.H5 L 358 G.H5.25
Polar ECL2 H 176 - G.H5 Y 356 G.H5.23
Hydrophobic ECL2 H 176 - G.H5 Y 356 G.H5.23
Van-der-waals ECL2 H 176 - G.H5 Y 356 G.H5.23
Polar ECL2 H 179 - G.S2 L 196 G.S2.08
Hydrophobic ECL2 H 179 - G.S2 L 196 G.S2.08
Van-der-waals ECL2 H 179 - G.S2 L 196 G.S2.08
Hydrophobic TM6 Y 249 6x51 G.H5 L 358 G.H5.25
Hydrophobic ECL2 H 176 - G.S3 V 199 G.S3.01
Hydrophobic N-term S 7 - G.S6 F 328 G.S6.05
Polar ECL2 Q 177 - G.s2s3 S 198 G.s2s3.02
Hydrophobic ECL2 Q 177 - G.s2s3 S 198 G.s2s3.02
Van-der-waals ECL2 Q 177 - G.s2s3 S 198 G.s2s3.02
Hydrophobic N-term V 21 - G.H5 R 338 G.H5.05
Van-der-waals N-term V 21 - G.H5 R 338 G.H5.05
Polar ECL3 N 262 - G.h2s4 T 224 G.h2s4.05
Polar N-term D 22 - G.H5 A 342 G.H5.09
Hydrophobic N-term D 22 - G.H5 A 342 G.H5.09
Van-der-waals N-term D 22 - G.H5 A 342 G.H5.09
Polar ECL2 D 189 - G.H5 E 355 G.H5.22
Hydrophobic ECL2 D 189 - G.H5 E 355 G.H5.22
Van-der-waals ECL2 D 189 - G.H5 E 355 G.H5.22
Polar N-term D 4 - G.S6 I 324 G.S6.01
Van-der-waals TM1 R 35 1x32 G.H5 Q 350 G.H5.17
Hydrophobic N-term D 22 - G.H5 F 339 G.H5.06
Van-der-waals N-term D 22 - G.H5 F 339 G.H5.06
Polar N-term S 7 - G.S6 S 326 G.S6.03
Hydrophobic N-term S 7 - G.S6 S 326 G.S6.03
Van-der-waals N-term S 7 - G.S6 S 326 G.S6.03
Hydrophobic ECL2 F 180 - G.S2 L 196 G.S2.08
Van-der-waals ECL2 F 180 - G.S2 L 196 G.S2.08
Polar TM6 Y 249 6x51 G.H5 V 359 G.H5.26
Van-der-waals TM6 Y 249 6x51 G.H5 V 359 G.H5.26
Polar TM6 A 259 6x61 G.H5 K 354 G.H5.21
Hydrophobic TM6 A 259 6x61 G.H5 K 354 G.H5.21
Van-der-waals TM6 A 259 6x61 G.H5 K 354 G.H5.21
Hydrophobic ECL3 P 261 - G.h3s5 N 266 G.h3s5.02
Hydrophobic N-term Y 13 - G.H5 F 339 G.H5.06
Hydrophobic N-term S 7 - G.H4 L 310 G.H4.12
Van-der-waals N-term S 7 - G.H4 L 310 G.H4.12
Polar ECL3 N 262 - G.h3s5 N 266 G.h3s5.02
Hydrophobic ECL3 N 262 - G.h3s5 N 266 G.h3s5.02
Van-der-waals ECL3 N 262 - G.h3s5 N 266 G.h3s5.02
Polar ECL3 N 262 - G.S5 S 268 G.S5.01
Hydrophobic ECL3 N 262 - G.S5 S 268 G.S5.01
Van-der-waals ECL3 N 262 - G.S5 S 268 G.S5.01
Polar ECL2 H 179 - G.s2s3 Q 197 G.s2s3.01
Hydrophobic ECL2 H 179 - G.s2s3 Q 197 G.s2s3.01
Van-der-waals ECL2 H 179 - G.s2s3 Q 197 G.s2s3.01
Polar TM6 L 256 6x58 G.H5 K 354 G.H5.21
Hydrophobic TM6 L 256 6x58 G.H5 K 354 G.H5.21
Van-der-waals TM6 L 256 6x58 G.H5 K 354 G.H5.21
Polar N-term Y 10 - G.HG K 276 G.HG.01
Van-der-waals N-term Y 10 - G.HG K 276 G.HG.01
Ionic ECL2 R 183 - G.H5 D 346 G.H5.13
Polar ECL2 R 183 - G.H5 D 346 G.H5.13
Van-der-waals ECL2 R 183 - G.H5 D 346 G.H5.13
Hydrophobic TM3 I 114 3x32 G.H5 V 359 G.H5.26
Van-der-waals TM3 I 114 3x32 G.H5 V 359 G.H5.26
Polar N-term Y 8 - G.S6 S 326 G.S6.03
Hydrophobic N-term Y 8 - G.S6 S 326 G.S6.03
Van-der-waals N-term Y 8 - G.S6 S 326 G.S6.03
Van-der-waals N-term S 5 - G.S6 I 324 G.S6.01
Polar TM6 T 257 6x59 G.H5 K 354 G.H5.21
Van-der-waals TM6 T 257 6x59 G.H5 K 354 G.H5.21
Van-der-waals ECL2 E 178 - G.H5 D 346 G.H5.13
Hydrophobic N-term S 5 - G.H4 V 314 G.H4.16
Van-der-waals N-term S 5 - G.H4 V 314 G.H4.16
Polar N-term N 3 - G.H4 D 315 G.H4.17
Aromatic N-term Y 10 - G.H5 F 339 G.H5.06
Hydrophobic N-term Y 10 - G.H5 F 339 G.H5.06
Van-der-waals N-term Y 10 - G.H5 F 339 G.H5.06
Hydrophobic TM6 G 253 6x55 G.H5 L 358 G.H5.25
Polar ECL2 G 192 - G.H5 E 355 G.H5.22
Polar N-term Y 10 - G.S6 H 327 G.S6.04
Hydrophobic N-term Y 10 - G.S6 H 327 G.S6.04
Van-der-waals N-term Y 10 - G.S6 H 327 G.S6.04
Polar N-term Y 8 - G.S6 F 328 G.S6.05