Gs - C5a2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 T 144 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 P 139 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM7 F 291 7x53 G.H5 E 392 G.H5.24
Van-der-waals TM7 F 291 7x53 G.H5 E 392 G.H5.24
Hydrophobic ICL2 T 144 34x55 G.S1 H 41 G.S1.02
Polar TM3 D 131 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 131 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 132 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 L 132 3x50 G.H5 L 393 G.H5.25
Polar TM3 L 137 3x55 G.H5 R 380 G.H5.12
Hydrophobic TM3 L 137 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 L 137 3x55 G.H5 R 380 G.H5.12
Polar TM3 G 138 3x56 G.H5 R 380 G.H5.12
Hydrophobic TM3 G 138 3x56 G.H5 R 380 G.H5.12
Van-der-waals TM3 G 138 3x56 G.H5 R 380 G.H5.12
Polar TM6 R 232 6x34 G.h4s6 Y 358 G.h4s6.20
Hydrophobic C-term A 310 - G.H5 E 392 G.H5.24
Van-der-waals C-term A 310 - G.H5 E 392 G.H5.24
Hydrophobic TM6 R 230 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 230 6x32 G.H5 L 394 G.H5.26
Ionic C-term E 313 - G.h4s6 R 356 G.h4s6.12
Polar C-term E 313 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term E 313 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term E 313 - G.h4s6 R 356 G.h4s6.12
Polar C-term Q 317 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term Q 317 - G.h2s4 N 239 G.h2s4.02
Hydrophobic TM3 L 132 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 234 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 L 234 6x36 G.H5 E 392 G.H5.24
Polar TM3 L 135 3x53 G.H5 R 380 G.H5.12
Van-der-waals TM3 L 135 3x53 G.H5 R 380 G.H5.12
Polar TM3 A 136 3x54 G.H5 R 380 G.H5.12
Hydrophobic TM3 A 136 3x54 G.H5 R 380 G.H5.12
Van-der-waals TM3 A 136 3x54 G.H5 R 380 G.H5.12
Hydrophobic ICL2 W 141 34x52 G.s2s3 K 216 G.s2s3.02
Ionic C-term E 313 - G.H5 R 389 G.H5.21
Polar TM6 R 232 6x34 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 232 6x34 G.H5 L 393 G.H5.25
Van-der-waals TM6 R 232 6x34 G.H5 L 393 G.H5.25
Hydrophobic ICL1 R 66 - G.hns1 R 38 G.hns1.02
Polar TM2 V 68 2x38 G.H5 Q 390 G.H5.22
Hydrophobic TM3 L 135 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 W 141 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 W 141 34x52 G.S3 V 217 G.S3.01
Polar TM2 R 67 2x37 G.H5 R 389 G.H5.21
Hydrophobic ICL2 V 145 34x56 G.HN Q 35 G.HN.52
Van-der-waals ICL2 V 145 34x56 G.HN Q 35 G.HN.52
Hydrophobic TM3 L 128 3x46 G.H5 L 393 G.H5.25
Van-der-waals TM3 L 128 3x46 G.H5 L 393 G.H5.25
Polar TM3 L 135 3x53 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 135 3x53 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 135 3x53 G.H5 Q 384 G.H5.16
Hydrophobic TM6 G 235 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 235 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 W 141 34x52 G.H5 F 376 G.H5.08
Van-der-waals ICL2 W 141 34x52 G.H5 F 376 G.H5.08
Polar TM3 A 136 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 A 136 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 A 136 3x54 G.H5 Q 384 G.H5.16
Polar TM6 R 232 6x34 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM6 R 232 6x34 G.h4s6 G 355 G.h4s6.11
Polar TM2 G 69 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 G 69 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 G 69 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 145 34x56 G.hns1 A 39 G.hns1.03
Hydrophobic TM3 L 132 3x50 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 132 3x50 G.H5 L 388 G.H5.20
Hydrophobic ICL2 A 140 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 A 140 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM6 I 238 6x40 G.H5 L 393 G.H5.25
Polar TM2 V 68 2x38 G.H5 Y 391 G.H5.23
Hydrophobic TM2 V 68 2x38 G.H5 Y 391 G.H5.23
Van-der-waals TM2 V 68 2x38 G.H5 Y 391 G.H5.23
Hydrophobic TM2 V 68 2x38 G.H5 H 387 G.H5.19
Hydrophobic ICL2 S 143 34x54 G.hns1 A 39 G.hns1.03
Polar TM6 R 232 6x34 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 232 6x34 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 232 6x34 G.H5 L 394 G.H5.26
Hydrophobic ICL2 A 140 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 A 140 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM2 G 69 2x39 G.H5 H 387 G.H5.19
Polar TM2 W 72 2x42 G.H5 Y 391 G.H5.23
Aromatic TM2 W 72 2x42 G.H5 Y 391 G.H5.23
Hydrophobic TM2 W 72 2x42 G.H5 Y 391 G.H5.23
Van-der-waals TM2 W 72 2x42 G.H5 Y 391 G.H5.23
Polar ICL2 T 144 34x55 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 T 144 34x55 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 T 144 34x55 G.hns1 R 38 G.hns1.02
Hydrophobic TM6 R 230 6x32 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 R 230 6x32 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 R 232 6x34 G.H5 R 389 G.H5.21
Hydrophobic TM3 L 128 3x46 G.H5 Y 391 G.H5.23
Van-der-waals C-term L 311 - G.H5 E 392 G.H5.24
Hydrophobic ICL2 A 140 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 A 140 34x51 G.H5 R 380 G.H5.12
Polar ICL2 W 141 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 W 141 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 W 141 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals C-term L 311 - G.H5 Q 390 G.H5.22
Polar ICL1 R 65 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 R 65 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 R 65 - G.hns1 R 38 G.hns1.02
Hydrophobic TM2 L 73 2x43 G.H5 Y 391 G.H5.23
Van-der-waals TM2 L 73 2x43 G.H5 Y 391 G.H5.23
Polar TM4 R 147 4x38 G.H5 H 387 G.H5.19
Aromatic TM4 R 147 4x38 G.H5 H 387 G.H5.19
Hydrophobic TM4 R 147 4x38 G.H5 H 387 G.H5.19
Van-der-waals TM4 R 147 4x38 G.H5 H 387 G.H5.19
Polar TM2 G 69 2x39 G.H5 Q 390 G.H5.22
Hydrophobic TM2 G 69 2x39 G.H5 Q 390 G.H5.22
Van-der-waals TM2 G 69 2x39 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 67 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 67 2x37 G.H5 Q 390 G.H5.22
Polar TM4 R 147 4x38 G.H5 Y 391 G.H5.23
Van-der-waals TM4 R 147 4x38 G.H5 Y 391 G.H5.23