Gi2 - CCK1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 I 296 - G.H5 F 335 G.H5.06
Hydrophobic C-term F 416 - G.s4h3 M 241 G.s4h3.14
Polar C-term Y 418 - G.H2 R 209 G.H2.04
Van-der-waals C-term Y 418 - G.H2 R 209 G.H2.04
Hydrophobic C-term M 421 - H.hdhe Q 148 H.hdhe.02
Van-der-waals C-term M 421 - H.hdhe Q 148 H.hdhe.02
Polar TM6 S 301 6x23 G.h4s6 K 315 G.h4s6.08
Hydrophobic TM6 S 301 6x23 G.h4s6 K 315 G.h4s6.08
Van-der-waals TM6 S 301 6x23 G.h4s6 K 315 G.h4s6.08
Polar TM6 N 304 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 I 296 - G.S6 H 323 G.S6.04
Hydrophobic C-term Y 418 - G.s1h1 A 41 G.s1h1.02
Hydrophobic TM6 A 307 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 A 307 6x29 G.H5 F 355 G.H5.26
Hydrophobic C-term Y 418 - G.s1h1 G 42 G.s1h1.03
Polar TM4 S 156 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 S 156 4x40 G.HN E 28 G.HN.52
Hydrophobic C-term S 419 - G.s4h3 A 236 G.s4h3.09
Van-der-waals C-term S 419 - G.s4h3 A 236 G.s4h3.09
Hydrophobic ICL2 L 147 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 L 147 34x51 G.H5 F 337 G.H5.08
Polar ICL2 R 150 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 150 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 M 314 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 M 314 6x36 G.H5 L 354 G.H5.25
Polar TM2 T 76 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 T 76 2x39 G.H5 D 351 G.H5.22
Hydrophobic C-term A 423 - G.hfs2 K 181 G.hfs2.04
Van-der-waals C-term A 423 - G.hfs2 K 181 G.hfs2.04
Hydrophobic TM5 L 236 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 147 34x51 G.H5 I 344 G.H5.15
Polar ICL2 R 150 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 150 34x54 G.S1 E 33 G.S1.01
Polar H8 R 376 8x49 G.H5 K 350 G.H5.21
Hydrophobic H8 R 376 8x49 G.H5 K 350 G.H5.21
Van-der-waals H8 R 376 8x49 G.H5 K 350 G.H5.21
Hydrophobic TM3 R 139 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 139 3x50 G.H5 L 354 G.H5.25
Polar TM3 A 142 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 142 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 N 348 G.H5.19
Hydrophobic C-term P 427 - H.HA Q 68 H.HA.06
Polar C-term Y 418 - G.H2 R 206 G.H2.01
Hydrophobic C-term Y 418 - G.H2 R 206 G.H2.01
Van-der-waals C-term Y 418 - G.H2 R 206 G.H2.01
Ionic H8 R 376 8x49 G.H5 D 351 G.H5.22
Polar H8 R 376 8x49 G.H5 D 351 G.H5.22
Van-der-waals H8 R 376 8x49 G.H5 D 351 G.H5.22
Hydrophobic TM6 A 303 6x25 G.h4s6 D 316 G.h4s6.09
Polar ICL2 R 150 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 150 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM4 T 154 4x38 G.HN E 28 G.HN.52
Hydrophobic C-term F 416 - G.H3 E 246 G.H3.04
Van-der-waals C-term F 416 - G.H3 E 246 G.H3.04
Hydrophobic C-term Y 418 - G.s3h2 Q 205 G.s3h2.03
Polar C-term S 424 - H.HA S 75 H.HA.13
Hydrophobic C-term S 424 - H.HA S 75 H.HA.13
Van-der-waals C-term S 424 - H.HA S 75 H.HA.13
Hydrophobic C-term P 426 - G.hfs2 V 180 G.hfs2.03
Van-der-waals C-term P 426 - G.hfs2 V 180 G.hfs2.03
Hydrophobic ICL3 N 299 - G.h4s6 E 319 G.h4s6.12
Polar C-term H 420 - G.hfs2 K 181 G.hfs2.04
Aromatic C-term H 420 - G.hfs2 K 181 G.hfs2.04
Van-der-waals C-term H 420 - G.hfs2 K 181 G.hfs2.04
Polar ICL3 S 300 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 S 300 - G.h4s6 E 319 G.h4s6.12
Polar ICL2 V 151 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 151 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 V 151 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 143 3x54 G.H5 L 354 G.H5.25
Van-der-waals TM3 I 143 3x54 G.H5 L 354 G.H5.25
Polar ICL3 S 298 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 S 298 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 V 311 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 311 6x33 G.H5 L 354 G.H5.25
Polar C-term S 417 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term S 417 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term S 417 - G.s4h3 E 237 G.s4h3.10
Polar TM3 R 139 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 C 352 G.H5.23
Polar ICL3 N 299 - G.S6 I 320 G.S6.01
Hydrophobic C-term P 426 - H.HA V 72 H.HA.10
Van-der-waals C-term P 426 - H.HA V 72 H.HA.10
Polar C-term H 420 - G.H2 R 206 G.H2.01
Aromatic C-term H 420 - G.H2 R 206 G.H2.01
Hydrophobic C-term H 420 - G.H2 R 206 G.H2.01
Van-der-waals C-term H 420 - G.H2 R 206 G.H2.01
Hydrophobic ICL2 L 147 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 147 34x51 G.S3 L 195 G.S3.01
Polar TM6 S 301 6x23 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 S 301 6x23 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 S 301 6x23 G.h4s6 D 316 G.h4s6.09
Hydrophobic ICL3 S 298 - G.S6 Y 321 G.S6.02
Hydrophobic TM3 A 142 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 A 142 3x53 G.H5 C 352 G.H5.23
Hydrophobic C-term F 416 - G.s4h3 L 235 G.s4h3.08
Polar TM3 R 139 3x50 G.H5 G 353 G.H5.24
Hydrophobic C-term A 423 - G.hfs2 V 180 G.hfs2.03
Polar ICL3 N 299 - G.H4 E 309 G.H4.16
Hydrophobic ICL3 N 299 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 N 299 - G.H4 E 309 G.H4.16
Hydrophobic TM6 L 315 6x37 G.H5 L 354 G.H5.25
Polar H8 N 374 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 N 374 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 N 374 8x47 G.H5 G 353 G.H5.24
Polar C-term S 424 - H.HA N 76 H.HA.14
Polar C-term S 419 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term S 419 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term S 419 - G.s4h3 E 237 G.s4h3.10
Hydrophobic ICL2 P 146 34x50 G.H5 I 344 G.H5.15
Hydrophobic ICL2 P 146 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM3 I 143 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 349 G.H5.20
Polar TM2 T 76 2x39 G.H5 C 352 G.H5.23
Hydrophobic TM2 T 76 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 T 76 2x39 G.H5 C 352 G.H5.23
Polar C-term Y 418 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term Y 418 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term Y 418 - G.s4h3 E 237 G.s4h3.10
Hydrophobic ICL2 R 150 34x54 G.H5 I 344 G.H5.15
Van-der-waals ICL2 R 150 34x54 G.H5 I 344 G.H5.15
Polar ICL3 R 297 - G.H4 Q 305 G.H4.12