G11 - CCR6 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 147 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM2 T 81 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 T 81 2x39 G.H5 Y 356 G.H5.23
Hydrophobic C-term F 372 - G.H2 R 213 G.H2.04
Van-der-waals C-term F 372 - G.H2 R 213 G.H2.04
Hydrophobic ICL2 F 154 34x54 G.S1 E 39 G.S1.01
Hydrophobic TM3 I 147 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 147 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 252 6x33 G.H5 L 353 G.H5.20
Aromatic C-term F 372 - G.H2 W 216 G.H2.07
Hydrophobic C-term F 372 - G.H2 W 216 G.H2.07
Van-der-waals C-term F 372 - G.H2 W 216 G.H2.07
Hydrophobic C-term M 374 - G.H2 I 217 G.H2.08
Van-der-waals C-term M 374 - G.H2 I 217 G.H2.08
Polar C-term F 372 - G.H3 Y 261 G.H3.15
Hydrophobic C-term F 372 - G.H3 Y 261 G.H3.15
Van-der-waals C-term F 372 - G.H3 Y 261 G.H3.15
Polar TM6 A 252 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 252 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 252 6x33 G.H5 L 358 G.H5.25
Hydrophobic C-term F 372 - G.H3 L 254 G.H3.08
Polar TM3 D 142 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 142 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 142 3x49 G.H5 Y 356 G.H5.23
Polar H8 Q 321 8x48 G.H5 V 359 G.H5.26
Hydrophobic H8 Q 321 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 Q 321 8x48 G.H5 V 359 G.H5.26
Hydrophobic ICL2 F 154 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic TM5 L 241 5x65 G.H5 L 349 G.H5.16
Hydrophobic C-term F 372 - G.H3 I 258 G.H3.12
Van-der-waals C-term F 372 - G.H3 I 258 G.H3.12
Polar C-term S 370 - G.H3 T 257 G.H3.11
Hydrophobic TM5 L 241 5x65 G.H5 L 353 G.H5.20
Ionic ICL2 R 157 - G.H5 E 355 G.H5.22
Polar ICL2 R 157 - G.H5 E 355 G.H5.22
Hydrophobic ICL2 R 157 - G.H5 E 355 G.H5.22
Van-der-waals ICL2 R 157 - G.H5 E 355 G.H5.22
Hydrophobic C-term I 356 - G.h3s5 Q 265 G.h3s5.01
Hydrophobic TM3 A 146 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 146 3x53 G.H5 Y 356 G.H5.23
Polar H8 G 320 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 G 320 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 G 320 8x47 G.H5 N 357 G.H5.24
Polar ICL3 N 246 - G.H5 D 346 G.H5.13
Hydrophobic ICL3 N 246 - G.H5 D 346 G.H5.13
Van-der-waals ICL3 N 246 - G.H5 D 346 G.H5.13
Hydrophobic TM3 R 143 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 143 3x50 G.H5 L 358 G.H5.25
Hydrophobic C-term M 374 - G.H2 H 218 G.H2.09
Van-der-waals C-term M 374 - G.H2 H 218 G.H2.09
Polar ICL2 S 153 34x53 G.H5 N 352 G.H5.19
Van-der-waals ICL2 S 153 34x53 G.H5 N 352 G.H5.19
Polar TM3 A 146 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 146 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 146 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 S 158 - G.hns1 R 37 G.hns1.02
Polar ICL3 N 246 - G.H5 Q 350 G.H5.17
Hydrophobic ICL3 N 246 - G.H5 Q 350 G.H5.17
Van-der-waals ICL3 N 246 - G.H5 Q 350 G.H5.17
Hydrophobic ICL2 R 155 34x55 G.hns1 R 38 G.hns1.03
Polar TM2 S 79 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM2 S 79 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 S 79 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM6 A 252 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM6 V 255 6x36 G.H5 L 358 G.H5.25
Hydrophobic TM5 A 244 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 A 244 5x68 G.H5 L 349 G.H5.16
Hydrophobic ICL3 N 246 - G.h4s6 I 323 G.h4s6.20
Van-der-waals ICL3 N 246 - G.h4s6 I 323 G.h4s6.20
Hydrophobic H8 G 320 8x47 G.H5 V 359 G.H5.26
Van-der-waals H8 G 320 8x47 G.H5 V 359 G.H5.26
Hydrophobic TM6 I 256 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM6 K 248 6x29 G.H5 V 359 G.H5.26
Ionic TM6 K 248 6x29 G.h4s6 D 321 G.h4s6.12
Polar TM6 K 248 6x29 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM6 K 248 6x29 G.h4s6 D 321 G.h4s6.12
Van-der-waals TM6 K 248 6x29 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM3 I 147 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 147 3x54 G.H5 L 349 G.H5.16
Aromatic C-term F 372 - G.h2s4 F 220 G.h2s4.01
Hydrophobic C-term F 372 - G.h2s4 F 220 G.h2s4.01
Polar TM3 R 143 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 143 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 143 3x50 G.H5 Y 356 G.H5.23
Hydrophobic C-term M 374 - G.H2 K 215 G.H2.06
Hydrophobic ICL2 R 159 - G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 R 159 - G.hns1 R 38 G.hns1.03
Polar TM7 Y 316 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 Y 316 7x53 G.H5 N 357 G.H5.24
Hydrophobic C-term M 374 - G.H2 R 214 G.H2.05
Van-der-waals C-term M 374 - G.H2 R 214 G.H2.05
Hydrophobic ICL2 F 154 34x54 G.S1 L 40 G.S1.02
Van-der-waals ICL2 F 154 34x54 G.S1 L 40 G.S1.02
Hydrophobic ICL2 T 151 34x51 G.H5 F 341 G.H5.08
Hydrophobic ICL2 F 154 34x54 G.hns1 R 38 G.hns1.03
Hydrophobic C-term T 360 - G.H3 P 262 G.H3.16
Van-der-waals C-term T 360 - G.H3 P 262 G.H3.16
Hydrophobic TM6 K 251 6x32 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 251 6x32 G.H5 V 359 G.H5.26
Hydrophobic C-term F 372 - G.H3 T 257 G.H3.11
Hydrophobic ICL2 T 151 34x51 G.S3 I 199 G.S3.01
Van-der-waals ICL2 T 151 34x51 G.S3 I 199 G.S3.01
Hydrophobic ICL2 A 150 34x50 G.H5 I 348 G.H5.15